SIMILAR PATTERNS OF AMINO ACIDS FOR 2REZ_A_ACTA155_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eks MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C

(Escherichia
coli) 		PF01967
(MoaC) 		4 ARG A  96
GLY A 140
PRO A 141
PHE A  33
 None
 0.97A 2rezA-1eksA:
0.0		 2rezA-1eksA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ARG A 489
GLY A  94
PRO A  93
PHE A  99
 None
 1.39A 2rezA-1hwwA:
0.8		 2rezA-1hwwA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuh HYPOTHETICAL PROTEIN
EGC068

(uncultured
bacterium) 		PF12680
(SnoaL_2) 		4 TRP A 148
GLY A  57
PRO A  56
PHE A 138
 None
 1.37A 2rezA-1tuhA:
1.5		 2rezA-1tuhA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		4 TRP C 917
GLY C 913
PRO C 908
PHE C 916
 None
 1.26A 2rezA-1w36C:
0.0		 2rezA-1w36C:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 TRP A 360
GLY A 245
PRO A 246
PHE A 220
 None
 1.42A 2rezA-2acvA:
0.0		 2rezA-2acvA:
14.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN

(Streptomyces
glaucescens) 		PF03364
(Polyketide_cyc) 		5 TRP A  65
ARG A  82
GLY A  86
PRO A  87
PHE A  88
 ACT  A 156 (-4.9A)
IOD  A 157 (-3.6A)
ACT  A 155 (-3.0A)
ACT  A 155 (-3.9A)
ACT  A 155 (-4.8A)
 0.00A 2rezA-2rezA:
30.5		 2rezA-2rezA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ARG A 118
GLY A 110
PRO A 111
PHE A 444
 None
 1.39A 2rezA-2uxtA:
0.0		 2rezA-2uxtA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		4 TRP X 155
GLY X 153
PRO X 152
PHE X 158
 None
 1.21A 2rezA-2zyvX:
0.0		 2rezA-2zyvX:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY

(Novosphingobium
aromaticivorans) 		PF08445
(FR47) 		4 ARG A 149
GLY A  37
PRO A  38
PHE A  39
 None
 0.87A 2rezA-3ec4A:
undetectable		 2rezA-3ec4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S9,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S35,
MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF00380
(Ribosomal_S9)
PF00411
(Ribosomal_S11) 		4 ARG k  88
GLY k  96
PRO I 133
PHE I 132
 None
 1.45A 2rezA-3jd5k:
undetectable		 2rezA-3jd5k:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 TRP A 155
GLY A 153
PRO A 152
PHE A 158
 None
 1.21A 2rezA-3qvuA:
undetectable		 2rezA-3qvuA:
18.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tl1 POLYKETIDE CYCLASE

(Streptomyces
coelicolor) 		PF03364
(Polyketide_cyc) 		4 TRP A  65
GLY A  86
PRO A  87
PHE A  88
 JRO  A 160 (-3.6A)
None
None
JRO  A 160 (-4.4A)
 0.39A 2rezA-3tl1A:
24.6		 2rezA-3tl1A:
56.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6u ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 ARG A  99
GLY A  32
PRO A  33
PHE A  52
 None
 0.89A 2rezA-4e6uA:
undetectable		 2rezA-4e6uA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		4 ARG A 372
GLY A 281
PRO A 280
PHE A 196
 None
 1.32A 2rezA-5cdiA:
undetectable		 2rezA-5cdiA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 4 TRP A2460
GLY A2439
PRO A2438
PHE A2041
 None
 1.44A 2rezA-6fayA:
undetectable		 2rezA-6fayA:
undetectable