SIMILAR PATTERNS OF AMINO ACIDS FOR 2RDD_A_AICA1110_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ix5 FKBP

(Methanothermococcus
thermolithotrophicus) 		PF00254
(FKBP_C) 		4 LYS A 141
ALA A  83
PHE A  61
GLY A  60
 None
 1.24A 2rddA-1ix5A:
0.0		 2rddA-1ix5A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LYS B 454
ALA B 495
PHE B 498
GLY B 497
 None
 1.49A 2rddA-1ldkB:
0.0		 2rddA-1ldkB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		4 LYS A 403
ALA A 385
PHE A 384
GLY A 381
 None
None
None
IMP  A 801 (-3.5A)
 1.42A 2rddA-1lrtA:
0.0		 2rddA-1lrtA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LYS A 403
ALA A 385
PHE A 384
GLY A 381
 None
None
None
XMP  A 602 (-3.6A)
 1.41A 2rddA-1mewA:
0.0		 2rddA-1mewA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LYS A 233
ALA A 221
PHE A 198
GLY A 199
 None
None
None
NAD  A1377 (-3.5A)
 1.00A 2rddA-1u3tA:
0.0		 2rddA-1u3tA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cp0 CLIPR-59 PROTEIN

(Homo sapiens) 		PF01302
(CAP_GLY) 		4 LYS A  82
ALA A  78
PHE A  77
GLY A  48
 None
 1.48A 2rddA-2cp0A:
undetectable		 2rddA-2cp0A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzc UDP-N-ACETYLGLUCOSAM
INE TRANSFERASE
SUBUNIT ALG13

(Saccharomyces
cerevisiae) 		PF04101
(Glyco_tran_28_C) 		4 LYS A  92
ALA A 104
PHE A 119
GLY A 118
 None
 1.25A 2rddA-2jzcA:
0.0		 2rddA-2jzcA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 LYS A 309
ALA A 214
PHE A 387
GLY A 210
 None
 1.33A 2rddA-2z8eA:
1.0		 2rddA-2z8eA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		4 LYS A 313
ALA A 261
PHE A 230
GLY A 264
 None
 1.42A 2rddA-3jrkA:
0.0		 2rddA-3jrkA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER

(Pseudomonas
aeruginosa) 		PF12974
(Phosphonate-bd) 		4 LYS A  44
ALA A  64
PHE A  65
GLY A  33
 None
 1.22A 2rddA-3n5lA:
undetectable		 2rddA-3n5lA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LYS A 386
ALA A 368
PHE A 367
GLY A 364
 None
None
None
XMP  A 500 (-3.5A)
 1.39A 2rddA-3tsdA:
0.0		 2rddA-3tsdA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdo MFS TRANSPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		4 LYS A 278
ALA A 385
PHE A 219
GLY A 220
 None
 1.47A 2rddA-3wdoA:
1.7		 2rddA-3wdoA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 LYS A 159
ALA A 130
PHE A 172
GLY A 128
 None
 1.32A 2rddA-3x0yA:
2.8		 2rddA-3x0yA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LYS A 385
ALA A 367
PHE A 366
GLY A 363
 None
None
None
IMP  A 701 (-3.7A)
 1.30A 2rddA-4fxsA:
undetectable		 2rddA-4fxsA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		4 LYS A 385
ALA A 367
PHE A 366
GLY A 363
 None
None
None
IMP  A 501 (-3.5A)
 1.38A 2rddA-4ix2A:
undetectable		 2rddA-4ix2A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 4 LYS B 120
ALA B 106
PHE B 107
GLY B 108
 None
 1.05A 2rddA-4mkiB:
undetectable		 2rddA-4mkiB:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeb LRA-12

(uncultured
bacterium BLR12) 		PF00753
(Lactamase_B) 		4 LYS A 130
ALA A 126
PHE A 165
GLY A 123
 None
 1.32A 2rddA-5aebA:
undetectable		 2rddA-5aebA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH) 		4 LYS A 382
ALA A 364
PHE A 363
GLY A 360
 None
None
None
IMP  A 501 (-3.7A)
 1.44A 2rddA-5ahmA:
undetectable		 2rddA-5ahmA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin)
PF06105
(Aph-1) 		4 LYS A 666
ALA C   4
PHE C   7
GLY C   8
 None
 1.44A 2rddA-5fn4A:
1.8		 2rddA-5fn4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		4 LYS A 386
ALA A 368
PHE A 367
GLY A 364
 None
None
None
IMP  A 501 (-3.7A)
 1.38A 2rddA-5uuwA:
undetectable		 2rddA-5uuwA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 4 LYS A 295
ALA A 301
PHE A 319
GLY A 322
 None
 1.31A 2rddA-5z9sA:
undetectable		 2rddA-5z9sA:
5.84