SIMILAR PATTERNS OF AMINO ACIDS FOR 2RCT_A_RTLA140_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3n PROTEIN (KETOACYL
ACYL CARRIER PROTEIN
SYNTHASE 2)

(Escherichia
coli) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 GLN A  31
THR A 334
TRP A  24
 None
 0.86A 2rctA-1b3nA:
0.0		 2rctA-1b3nA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLN A 293
THR A 451
TRP A 226
 None
 0.90A 2rctA-1ciyA:
0.0		 2rctA-1ciyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggv DIENELACTONE
HYDROLASE

(Pseudomonas
putida) 		PF01738
(DLH) 		3 GLN A 232
THR A 224
TRP A  50
 None
 1.09A 2rctA-1ggvA:
0.0		 2rctA-1ggvA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		3 GLN A 115
THR A 304
TRP A  79
 None
HEM  A 800 (-3.4A)
None
 1.09A 2rctA-1itkA:
0.0		 2rctA-1itkA:
11.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		3 GLN A  38
THR A  51
TRP A 106
 None
 0.17A 2rctA-1kqxA:
24.7		 2rctA-1kqxA:
72.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3g DUAL SPECIFICITY
PROTEIN PHOSPHATASE
2

(Homo sapiens) 		PF00782
(DSPc) 		3 GLN A 310
THR A 266
TRP A 235
 None
 1.02A 2rctA-1m3gA:
0.0		 2rctA-1m3gA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 GLN A 353
THR A 638
TRP A 562
 None
 0.83A 2rctA-1n76A:
0.0		 2rctA-1n76A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 GLN A 157
THR A  92
TRP A 187
 None
 1.12A 2rctA-1ryyA:
0.0		 2rctA-1ryyA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 GLN A 197
THR A 336
TRP A 412
 None
 1.15A 2rctA-1suvA:
undetectable		 2rctA-1suvA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv6 2-KETO-4-PENTENOATE
HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 GLN A  71
THR A 154
TRP A 147
 None
 1.18A 2rctA-1sv6A:
undetectable		 2rctA-1sv6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		3 GLN C 181
THR C  97
TRP C  93
 None
 1.00A 2rctA-1w36C:
undetectable		 2rctA-1w36C:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		3 GLN A 197
THR A 122
TRP A 282
 None
 1.12A 2rctA-1wkyA:
undetectable		 2rctA-1wkyA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsj RIBONUCLEASE HI

(Escherichia
coli) 		PF00075
(RNase_H) 		3 GLN A  72
THR A   9
TRP A 118
 None
 0.95A 2rctA-1wsjA:
undetectable		 2rctA-1wsjA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		3 GLN A 517
THR A 523
TRP A 101
 None
 0.83A 2rctA-1yt8A:
undetectable		 2rctA-1yt8A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLN A 118
THR A 111
TRP A 163
 None
 0.72A 2rctA-2ag1A:
undetectable		 2rctA-2ag1A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crr STROMAL
MEMBRANE-ASSOCIATED
PROTEIN SMAP1B

(Homo sapiens) 		PF01412
(ArfGap) 		3 GLN A  86
THR A  78
TRP A  45
 None
 1.15A 2rctA-2crrA:
undetectable		 2rctA-2crrA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl5 IMMUNOGLOBULIN IGG1
HEAVY CHAIN

(Homo sapiens) 		no annotation 3 GLN H  82
THR H 107
TRP H  36
 None
 1.02A 2rctA-2fl5H:
undetectable		 2rctA-2fl5H:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLN A 222
THR A 425
TRP A 107
 None
None
CU  A 603 ( 4.4A)
 1.11A 2rctA-2hzhA:
undetectable		 2rctA-2hzhA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		3 GLN A 117
THR A  73
TRP A  18
 None
None
GOL  A 220 (-3.5A)
 1.15A 2rctA-2in3A:
undetectable		 2rctA-2in3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lll LAMIN-B2

(Homo sapiens) 		PF00932
(LTD) 		3 GLN A 467
THR A 542
TRP A 534
 None
 1.16A 2rctA-2lllA:
undetectable		 2rctA-2lllA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 GLN A 197
THR A 159
TRP A 111
 None
 1.18A 2rctA-2nq5A:
undetectable		 2rctA-2nq5A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		3 GLN A  28
THR A 297
TRP A 250
 None
 1.18A 2rctA-2qzpA:
undetectable		 2rctA-2qzpA:
12.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 GLN A  38
THR A  51
TRP A 106
 None
 0.08A 2rctA-2rcqA:
29.6		 2rctA-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whl BETA-MANNANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		3 GLN A 166
THR A  91
TRP A 251
 None
MAN  A1301 ( 4.4A)
MAN  A1301 (-4.5A)
 1.15A 2rctA-2whlA:
undetectable		 2rctA-2whlA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		3 GLN A 392
THR A 179
TRP A 416
 None
 1.07A 2rctA-2xtsA:
undetectable		 2rctA-2xtsA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqb RIBONUCLEASE HI

(Shewanella
oneidensis) 		PF00075
(RNase_H) 		3 GLN A  74
THR A  11
TRP A 120
 None
 0.95A 2rctA-2zqbA:
undetectable		 2rctA-2zqbA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 3 GLN C 201
THR C  72
TRP C 206
 None
 1.11A 2rctA-3amjC:
undetectable		 2rctA-3amjC:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 GLN A 197
THR A 186
TRP A 334
 None
 0.88A 2rctA-3bc9A:
undetectable		 2rctA-3bc9A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bze HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHA CHAIN
E

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 GLN A 226
THR A 200
TRP A 244
 None
 1.14A 2rctA-3bzeA:
undetectable		 2rctA-3bzeA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c60 TCR YAE62 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLN B  83
THR B 105
TRP B  32
 None
 1.17A 2rctA-3c60B:
undetectable		 2rctA-3c60B:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		3 GLN A  64
THR A  57
TRP A  79
 None
 1.14A 2rctA-3c87A:
undetectable		 2rctA-3c87A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1

(Homo sapiens) 		PF00640
(PID) 		3 GLN A 445
THR A 474
TRP A 377
 None
 1.15A 2rctA-3d8dA:
2.1		 2rctA-3d8dA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 GLN A1178
THR A1145
TRP A1232
 None
 1.09A 2rctA-3egwA:
undetectable		 2rctA-3egwA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		3 GLN A 535
THR A 492
TRP A 453
 None
 1.16A 2rctA-3eqnA:
undetectable		 2rctA-3eqnA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		3 GLN A 122
THR A 208
TRP A 272
 None
 0.94A 2rctA-3ez1A:
undetectable		 2rctA-3ez1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1p PROTEIN PHNP

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		3 GLN A  38
THR A   6
TRP A  64
 None
 0.97A 2rctA-3g1pA:
undetectable		 2rctA-3g1pA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2n WD REPEAT-CONTAINING
PROTEIN 92

(Homo sapiens) 		PF00400
(WD40) 		3 GLN A 264
THR A 261
TRP A 168
 None
 1.03A 2rctA-3i2nA:
undetectable		 2rctA-3i2nA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		3 GLN A 308
THR A 114
TRP A 344
 None
 1.15A 2rctA-3iu0A:
undetectable		 2rctA-3iu0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 GLN A 522
THR A 577
TRP A 512
 None
 1.12A 2rctA-3jb9A:
undetectable		 2rctA-3jb9A:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jca INTEGRASE

(Mouse mammary
tumor virus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		3 GLN A 117
THR A  84
TRP A 255
 None
 1.15A 2rctA-3jcaA:
undetectable		 2rctA-3jcaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jug BETA-MANNANASE

(Bacillus sp.
N16-5) 		PF00150
(Cellulase) 		3 GLN A 197
THR A 122
TRP A 282
 None
 1.09A 2rctA-3jugA:
undetectable		 2rctA-3jugA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		3 GLN A 457
THR A 466
TRP A 452
 None
 1.03A 2rctA-3k7dA:
undetectable		 2rctA-3k7dA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		3 GLN A  75
THR A  67
TRP A 313
 None
 1.15A 2rctA-3kkjA:
undetectable		 2rctA-3kkjA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		3 GLN B 250
THR B 695
TRP B 739
 EDO  B 900 (-2.9A)
None
None
 0.81A 2rctA-3l91B:
undetectable		 2rctA-3l91B:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		3 GLN B 699
THR B 405
TRP B 378
 None
None
EDO  B 915 ( 3.5A)
 0.88A 2rctA-3l91B:
undetectable		 2rctA-3l91B:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		3 GLN A  30
THR A 289
TRP A 291
 None
None
XYP  A 450 ( 4.1A)
 1.07A 2rctA-3msgA:
undetectable		 2rctA-3msgA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF00740
(Parvo_coat) 		3 GLN A 507
THR A 491
TRP A 475
 None
 1.08A 2rctA-3nttA:
undetectable		 2rctA-3nttA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF)
PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		3 GLN B 114
THR B 154
TRP A 155
 None
 1.09A 2rctA-3ojyB:
undetectable		 2rctA-3ojyB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p01 TWO-COMPONENT
RESPONSE REGULATOR

(Nostoc sp. PCC
7120) 		PF13185
(GAF_2) 		3 GLN A 210
THR A 229
TRP A 222
 None
 0.96A 2rctA-3p01A:
undetectable		 2rctA-3p01A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		3 GLN A 145
THR A 106
TRP A 462
 None
 1.11A 2rctA-3p2cA:
undetectable		 2rctA-3p2cA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		3 GLN A 192
THR A  65
TRP A 189
 None
 1.10A 2rctA-3pvcA:
undetectable		 2rctA-3pvcA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 GLN A 152
THR A  94
TRP A 119
 None
 1.17A 2rctA-3qlbA:
3.0		 2rctA-3qlbA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rzv STAM-BINDING PROTEIN

(Homo sapiens) 		PF01398
(JAB) 		3 GLN A 323
THR A 313
TRP A 333
 None
 0.99A 2rctA-3rzvA:
undetectable		 2rctA-3rzvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		3 GLN B 741
THR B 653
TRP B 649
 None
 1.05A 2rctA-3s4wB:
undetectable		 2rctA-3s4wB:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A  30
THR A 330
TRP A 289
 None
PG4  A 372 ( 4.0A)
None
 1.04A 2rctA-3tcsA:
undetectable		 2rctA-3tcsA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE

(Mycolicibacterium
thermoresistibile) 		PF03308
(ArgK) 		3 GLN A 256
THR A 168
TRP A 248
 None
 1.18A 2rctA-3tk1A:
undetectable		 2rctA-3tk1A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		3 GLN A 160
THR A 358
TRP A 124
 None
HEM  A1500 (-3.3A)
None
 1.07A 2rctA-3ut2A:
undetectable		 2rctA-3ut2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		3 GLN A 192
THR A 422
TRP A 466
 None
 1.08A 2rctA-3wmyA:
undetectable		 2rctA-3wmyA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpw POMB

(Vibrio
alginolyticus) 		PF00691
(OmpA) 		3 GLN A 250
THR A 231
TRP A 245
 None
 1.19A 2rctA-3wpwA:
undetectable		 2rctA-3wpwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		3 GLN A 217
THR A 139
TRP A 303
 None
 1.18A 2rctA-3wsuA:
undetectable		 2rctA-3wsuA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		3 GLN A 114
THR A 307
TRP A  78
 None
HEM  A 801 ( 3.3A)
None
 1.14A 2rctA-3wxoA:
undetectable		 2rctA-3wxoA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 GLN A  54
THR A 103
TRP A 109
 None
 0.97A 2rctA-4aieA:
undetectable		 2rctA-4aieA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		3 GLN A  96
THR A 122
TRP A 207
 None
 1.18A 2rctA-4aweA:
undetectable		 2rctA-4aweA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		3 GLN A 361
THR A 354
TRP A 349
 EDO  A1502 (-4.3A)
EDO  A1500 (-3.0A)
NGO  A1495 ( 3.4A)
 1.13A 2rctA-4c7gA:
undetectable		 2rctA-4c7gA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 3 GLN D  32
THR D 336
TRP D  25
 None
 0.97A 2rctA-4jrmD:
undetectable		 2rctA-4jrmD:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly4 PEPTIDOGLYCAN
DEACETYLASE

(Helicobacter
pylori) 		PF01522
(Polysacc_deac_1) 		3 GLN A 229
THR A 245
TRP A 196
 None
 1.03A 2rctA-4ly4A:
undetectable		 2rctA-4ly4A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly7 RIBONUCLEASE H

(unidentified) 		PF00075
(RNase_H) 		3 GLN A  72
THR A   9
TRP A 118
 None
 0.94A 2rctA-4ly7A:
undetectable		 2rctA-4ly7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 3 GLN A 479
THR A 471
TRP A 381
 None
 1.18A 2rctA-4qnlA:
undetectable		 2rctA-4qnlA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 GLN A  31
THR A 334
TRP A  24
 None
 1.07A 2rctA-4r8eA:
undetectable		 2rctA-4r8eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 3 GLN A 218
THR A 596
TRP A 196
 None
BGC  A 703 (-3.5A)
BGC  A 703 (-3.7A)
 1.08A 2rctA-4tz5A:
undetectable		 2rctA-4tz5A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 GLN A 510
THR A 501
TRP A 472
 None
 1.18A 2rctA-4u33A:
undetectable		 2rctA-4u33A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		3 GLN A 172
THR A 313
TRP A 204
 None
 1.12A 2rctA-4v1uA:
undetectable		 2rctA-4v1uA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 GLN A 221
THR A 193
TRP A 200
 None
 1.10A 2rctA-4w87A:
undetectable		 2rctA-4w87A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE

(Bifidobacterium
longum) 		PF01636
(APH) 		3 GLN A  48
THR A  52
TRP A  91
 ATP  A 401 (-3.4A)
None
None
 1.08A 2rctA-4wh3A:
undetectable		 2rctA-4wh3A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 GLN A 171
THR A 194
TRP A 201
 None
None
XYL  A2015 (-3.6A)
 1.06A 2rctA-4xwhA:
undetectable		 2rctA-4xwhA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 GLN A 624
THR A 137
TRP A 103
 None
 0.96A 2rctA-4xwhA:
undetectable		 2rctA-4xwhA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 3 GLN A 395
THR A 469
TRP A 601
 None
 1.15A 2rctA-5awpA:
undetectable		 2rctA-5awpA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 GLN A  58
THR A 107
TRP A 113
 None
 0.87A 2rctA-5brqA:
undetectable		 2rctA-5brqA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 GLN A 460
THR A 772
TRP A 584
 None
MD1  A1004 (-3.8A)
MD1  A1004 (-4.2A)
 1.12A 2rctA-5chcA:
undetectable		 2rctA-5chcA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo WD REPEAT-CONTAINING
PROTEIN 48
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46

(Homo sapiens;
Homo sapiens) 		PF00400
(WD40)
PF00443
(UCH) 		3 GLN B 239
THR B 187
TRP A 256
 None
 1.15A 2rctA-5cvoB:
undetectable		 2rctA-5cvoB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dih MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		PF00936
(BMC) 		3 GLN A 100
THR A 163
TRP A 114
 None
 1.18A 2rctA-5dihA:
undetectable		 2rctA-5dihA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		3 GLN A 198
THR A 205
TRP A 102
 None
None
5O8  A 301 (-4.4A)
 1.14A 2rctA-5ei3A:
undetectable		 2rctA-5ei3A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		3 GLN A 378
THR A 439
TRP A 384
 None
None
DQR  A 544 (-4.1A)
 1.13A 2rctA-5g5zA:
undetectable		 2rctA-5g5zA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 GLN A 302
THR A 185
TRP A 203
 None
 1.17A 2rctA-5gn5A:
undetectable		 2rctA-5gn5A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		3 GLN A 131
THR A 323
TRP A  95
 None
HEM  A 801 (-3.4A)
None
 1.15A 2rctA-5kqiA:
undetectable		 2rctA-5kqiA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		3 GLN A 195
THR A 244
TRP A 626
 None
 1.08A 2rctA-5m60A:
undetectable		 2rctA-5m60A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 3 GLN A 330
THR A 296
TRP A 211
 None
 1.16A 2rctA-5obuA:
undetectable		 2rctA-5obuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 3 GLN A 570
THR A 468
TRP A 507
 None
 1.18A 2rctA-5ohsA:
undetectable		 2rctA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		3 GLN A  34
THR A 479
TRP A 523
 None
 0.79A 2rctA-5ubkA:
undetectable		 2rctA-5ubkA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		3 GLN A 483
THR A 189
TRP A 162
 None
None
83M  A 801 (-4.4A)
 1.05A 2rctA-5ubkA:
undetectable		 2rctA-5ubkA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa) 		no annotation 3 GLN X 251
THR X 221
TRP X  84
 None
 1.05A 2rctA-5vtmX:
undetectable		 2rctA-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 3 GLN B 750
THR B 673
TRP B 655
 None
 1.15A 2rctA-5wfcB:
undetectable		 2rctA-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		3 GLN A 605
THR A  89
TRP A 645
 None
None
MB5  A 718 (-4.3A)
 0.94A 2rctA-5wgxA:
undetectable		 2rctA-5wgxA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aliivibrio
fischeri) 		no annotation 3 GLN A 345
THR A 228
TRP A 351
 None
 0.71A 2rctA-5xi0A:
undetectable		 2rctA-5xi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1) 		no annotation 3 GLN A  69
THR A  56
TRP A 131
 None
 0.95A 2rctA-5xzuA:
undetectable		 2rctA-5xzuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y16 DUAL SPECIFICITY
PHOSPHATASE 28

(Homo sapiens) 		no annotation 3 GLN A 158
THR A 115
TRP A 147
 None
 0.95A 2rctA-5y16A:
undetectable		 2rctA-5y16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhj CYTOCHROME P450

(Exiguobacterium
sp. AT1b) 		no annotation 3 GLN A 371
THR A 241
TRP A 146
 None
HEM  A 501 (-3.4A)
None
 0.48A 2rctA-5yhjA:
undetectable		 2rctA-5yhjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 3 GLN A 510
THR A 571
TRP A 480
 None
 1.02A 2rctA-5z06A:
undetectable		 2rctA-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cud SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 3

(Homo sapiens) 		no annotation 3 GLN A 481
THR A 419
TRP A 517
 None
 1.08A 2rctA-6cudA:
undetectable		 2rctA-6cudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 3 GLN A 181
THR A 209
TRP A 237
 None
 1.09A 2rctA-6eotA:
undetectable		 2rctA-6eotA:
undetectable