SIMILAR PATTERNS OF AMINO ACIDS FOR 2RCT_A_RTLA140_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aua PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
SEC14P

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 MET A  75
ALA A  64
ARG A  60
TYR A 205
VAL A 148
 None
BOG  A   1 ( 4.5A)
None
None
None
 1.10A 2rctA-1auaA:
undetectable		 2rctA-1auaA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link) 		5 MET A 181
ILE A 194
ALA A 199
VAL A 186
LEU A 183
 None
 1.21A 2rctA-1c9lA:
undetectable		 2rctA-1c9lA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 ILE A 374
ALA A 358
TYR A 381
LEU A 377
LEU A 302
 None
 1.32A 2rctA-1crlA:
0.0		 2rctA-1crlA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 PHE C 338
ALA C 239
ARG C 323
TYR C 350
VAL C 128
 None
 1.36A 2rctA-1ea9C:
0.0		 2rctA-1ea9C:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 PHE A 297
MET A 329
ALA A 293
VAL A 366
LEU A 377
 None
 1.10A 2rctA-1fc9A:
0.0		 2rctA-1fc9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ILE A 131
ALA A 129
TYR A 105
LEU A 148
GLN A 360
 None
 1.26A 2rctA-1fcpA:
0.8		 2rctA-1fcpA:
11.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 ILE A  25
ALA A  33
LYS A  40
THR A  53
TYR A  60
VAL A  62
LEU A 117
 None
 0.79A 2rctA-1gglA:
23.1		 2rctA-1gglA:
49.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LYS A  40
THR A  53
ARG A  58
TYR A  60
VAL A  62
LEU A 117
 None
 0.99A 2rctA-1gglA:
23.1		 2rctA-1gglA:
49.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		5 ALA A 178
THR A 156
TYR A 159
LEU A 172
LEU A 212
 None
 1.19A 2rctA-1ixpA:
undetectable		 2rctA-1ixpA:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		8 ILE A  25
ALA A  33
LYS A  40
THR A  53
VAL A  62
LEU A  77
GLN A 108
LEU A 117
 None
 1.11A 2rctA-1kqxA:
24.7		 2rctA-1kqxA:
72.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		9 PHE A  16
MET A  20
ILE A  25
ALA A  33
LYS A  40
THR A  53
VAL A  62
GLN A 108
LEU A 117
 None
 0.64A 2rctA-1kqxA:
24.7		 2rctA-1kqxA:
72.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		10 PHE A  16
MET A  20
ILE A  25
ALA A  33
LYS A  40
THR A  53
ARG A  58
VAL A  62
LEU A  77
LEU A 117
 None
 0.84A 2rctA-1lpjA:
24.8		 2rctA-1lpjA:
56.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		5 ILE A 601
ALA A 361
LEU A 356
GLN A 407
LEU A 403
 None
 1.09A 2rctA-1uf2A:
undetectable		 2rctA-1uf2A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		5 ILE A 347
ALA A 210
THR A 128
LEU A 344
LEU A 104
 None
 1.16A 2rctA-1vgmA:
undetectable		 2rctA-1vgmA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1s RAS-RELATED PROTEIN
M-RAS

(Mus musculus) 		PF00071
(Ras) 		5 ILE A 150
TYR A  92
VAL A  94
LEU A 123
LEU A  29
 None
 0.92A 2rctA-1x1sA:
undetectable		 2rctA-1x1sA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3j RNA AND EXPORT
FACTOR BINDING
PROTEIN 2

(Mus musculus) 		PF00076
(RRM_1)
PF07078
(FYTT) 		5 ALA A 151
VAL A 106
LEU A  78
GLN A  92
LEU A 101
 None
 1.22A 2rctA-2f3jA:
undetectable		 2rctA-2f3jA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 PHE A  16
ALA A  14
ARG A  11
VAL A 300
LEU A 555
 None
 1.20A 2rctA-2fonA:
undetectable		 2rctA-2fonA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		5 MET A 362
ALA A 336
LEU A 329
GLN A 227
LEU A 266
 None
 1.36A 2rctA-2i9uA:
undetectable		 2rctA-2i9uA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsj DNA REPAIR PROTEIN
REV1

(Mus musculus) 		PF16727
(REV1_C) 		5 MET A  85
ILE A  44
ALA A  96
LEU A  40
LEU A 116
 None
 1.10A 2rctA-2lsjA:
undetectable		 2rctA-2lsjA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 MET A  32
ILE A 360
ALA A 372
VAL A 291
LEU A 362
 None
 1.31A 2rctA-2o1bA:
undetectable		 2rctA-2o1bA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og7 ASPARAGINE OXYGENASE

(Streptomyces
coelicolor) 		PF02668
(TauD) 		5 PHE A 208
VAL A 191
LEU A 229
GLN A 260
LEU A 242
 None
 1.34A 2rctA-2og7A:
undetectable		 2rctA-2og7A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 PHE A 167
ALA A 230
THR A  15
TYR A  13
LEU A  48
 None
 1.39A 2rctA-2ohhA:
undetectable		 2rctA-2ohhA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pft EXOCYTOSIS PROTEIN

(Mus musculus) 		PF03081
(Exo70) 		5 ALA A 440
TYR A 466
VAL A 470
LEU A 394
LEU A 432
 None
 1.28A 2rctA-2pftA:
undetectable		 2rctA-2pftA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 ILE A 301
ALA A 236
ARG A 237
LEU A 250
LEU A 273
 None
 1.32A 2rctA-2q8hA:
undetectable		 2rctA-2q8hA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 300
ALA A 193
THR A 185
TYR A 186
LEU A 219
 None
None
None
GOL  A 601 ( 4.5A)
None
 1.33A 2rctA-2q9gA:
undetectable		 2rctA-2q9gA:
15.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		11 PHE A  16
MET A  20
ILE A  25
ALA A  33
LYS A  40
THR A  53
ARG A  58
VAL A  62
LEU A  77
GLN A 108
LEU A 117
 None
None
None
None
None
None
SO4  A 152 (-3.1A)
None
None
None
None
 0.49A 2rctA-2rcqA:
29.6		 2rctA-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhd SMALL GTP BINDING
PROTEIN RAB1A

(Cryptosporidium
parvum) 		PF00071
(Ras) 		5 ILE A 146
TYR A  89
VAL A  91
LEU A 119
LEU A  25
 None
 0.92A 2rctA-2rhdA:
undetectable		 2rctA-2rhdA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		5 PHE A  26
ALA A  98
THR A 149
ARG A 145
LEU A  39
 None
GOL  A1302 (-3.1A)
None
None
None
 1.36A 2rctA-2vg2A:
undetectable		 2rctA-2vg2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 PHE A 845
ILE A 856
THR A 820
LEU A 832
LEU A 824
 None
 1.24A 2rctA-2wfhA:
undetectable		 2rctA-2wfhA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		5 PHE A 596
ALA A 593
TYR A 553
VAL A 527
LEU A 602
 None
 1.30A 2rctA-2yhgA:
undetectable		 2rctA-2yhgA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 ILE A 222
ALA A 164
THR A 114
VAL A 139
LEU A  51
 UNL  A 420 (-4.1A)
UNL  A 420 (-3.6A)
None
None
None
 1.25A 2rctA-3b9yA:
undetectable		 2rctA-3b9yA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		5 ILE A 380
ALA A 432
VAL A 400
LEU A 391
LEU A 352
 None
 1.00A 2rctA-3bc8A:
undetectable		 2rctA-3bc8A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cph RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 ILE A 156
TYR A 100
VAL A 102
LEU A 130
LEU A  36
 None
 0.91A 2rctA-3cphA:
undetectable		 2rctA-3cphA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpr DIHYDRODIPICOLINATE
SYNTHETASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 MET A  24
ALA A  43
VAL A 303
LEU A 269
LEU A 227
 None
 1.31A 2rctA-3cprA:
undetectable		 2rctA-3cprA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		5 PHE A 174
MET A 291
ILE A 294
ARG A 321
GLN A 311
 None
 1.34A 2rctA-3d0qA:
undetectable		 2rctA-3d0qA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		5 ILE A 244
ALA A 214
THR A 157
VAL A 183
GLN A 164
 None
 1.32A 2rctA-3eqaA:
undetectable		 2rctA-3eqaA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		PF00616
(RasGAP) 		5 PHE A1058
ALA A1013
TYR A1158
VAL A1272
LEU A1023
 None
 1.39A 2rctA-3fayA:
undetectable		 2rctA-3fayA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		5 ILE A 235
ARG A 420
VAL A 417
GLN A 440
LEU A 436
 None
 1.31A 2rctA-3gjuA:
undetectable		 2rctA-3gjuA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 PHE A 234
MET A 233
ILE A 228
ALA A 256
GLN A 386
 None
 1.39A 2rctA-3js8A:
undetectable		 2rctA-3js8A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8i 30KLP

(Treponema
pallidum) 		no annotation 5 ILE A  62
ARG A  61
TYR A 225
LEU A  58
LEU A 216
 None
 1.26A 2rctA-3k8iA:
undetectable		 2rctA-3k8iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke2 UNCHARACTERIZED
PROTEIN YP_928783.1

(Shewanella
amazonensis) 		PF09904
(HTH_43) 		5 PHE A  56
ALA A  52
ARG A  20
TYR A  23
VAL A  94
 None
 1.24A 2rctA-3ke2A:
undetectable		 2rctA-3ke2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktd PREPHENATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF02153
(PDH) 		5 MET A  77
ILE A  80
ALA A 105
THR A 149
VAL A 170
 None
 1.38A 2rctA-3ktdA:
undetectable		 2rctA-3ktdA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 211
ARG A 187
VAL A 151
LEU A 186
GLN A 145
 None
 1.29A 2rctA-3kumA:
undetectable		 2rctA-3kumA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvn UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MEDO-DIAMINOP
IMELATE LIGASE

([Haemophilus]
ducreyi) 		PF02875
(Mur_ligase_C) 		5 ILE A 344
ALA A 334
VAL A 398
LEU A 380
LEU A 418
 None
 1.39A 2rctA-3mvnA:
undetectable		 2rctA-3mvnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pft FLAVIN REDUCTASE

(Mycolicibacterium
goodii) 		PF01613
(Flavin_Reduct) 		5 PHE A  53
ILE A  73
ALA A  38
LEU A  71
LEU A 124
 None
None
FMN  A 401 (-3.5A)
None
None
 1.11A 2rctA-3pftA:
undetectable		 2rctA-3pftA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puf RIBONUCLEASE H2
SUBUNIT B

(Homo sapiens) 		PF09468
(RNase_H2-Ydr279) 		5 ALA B 104
THR B 142
TYR B 156
LEU B 113
LEU B  94
 None
 1.22A 2rctA-3pufB:
undetectable		 2rctA-3pufB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 ILE A 283
ALA A 197
TYR A 205
VAL A 209
LEU A 279
 None
 1.26A 2rctA-3s1sA:
undetectable		 2rctA-3s1sA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slu M23 PEPTIDASE DOMAIN
PROTEIN

(Neisseria
meningitidis) 		PF01551
(Peptidase_M23) 		5 PHE A 190
ILE A 224
ALA A 238
LEU A 207
LEU A 199
 None
 1.31A 2rctA-3sluA:
undetectable		 2rctA-3sluA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 RAS-RELATED PROTEIN
RAB-35

(Homo sapiens) 		PF00071
(Ras) 		5 ILE B 144
TYR B  88
VAL B  90
LEU B 117
LEU B  24
 None
 0.96A 2rctA-3tw8B:
undetectable		 2rctA-3tw8B:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 ALA A 498
ARG A 465
VAL A 458
LEU A 461
LEU A 369
 None
 1.38A 2rctA-3v4oA:
undetectable		 2rctA-3v4oA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
MET A  20
ALA A  33
THR A  53
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 ( 3.9A)
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.0A)
None
 0.73A 2rctA-3wbgA:
20.2		 2rctA-3wbgA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdb PROTEIN XNI

(Escherichia
coli) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		5 PHE A  88
ALA A  47
TYR A 143
LEU A  36
GLN A  21
 None
None
ACT  A1254 ( 4.9A)
ACT  A1254 (-4.8A)
None
 1.33A 2rctA-3zdbA:
undetectable		 2rctA-3zdbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 PHE A 608
ILE A 799
ALA A 640
LEU A 795
LEU A 590
 None
 1.38A 2rctA-3zuqA:
undetectable		 2rctA-3zuqA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster) 		no annotation 5 ALA A 406
THR A 572
ARG A 423
LEU A 469
GLN A 431
 None
None
AN2  A1788 (-2.8A)
None
None
 1.36A 2rctA-4bwpA:
undetectable		 2rctA-4bwpA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 ILE A 551
ALA A 572
VAL A 787
LEU A 549
LEU A 221
 None
 1.29A 2rctA-4ci8A:
undetectable		 2rctA-4ci8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 MET A 252
ILE A 282
ALA A 266
VAL A 346
LEU A 387
 None
 1.19A 2rctA-4e4gA:
undetectable		 2rctA-4e4gA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2p CHAPERONE SURA

(Salmonella
enterica) 		PF13616
(Rotamase_3) 		5 PHE A 321
ILE A 310
ALA A 325
LEU A 307
LEU A 360
 None
 1.13A 2rctA-4g2pA:
undetectable		 2rctA-4g2pA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		5 PHE A 206
ILE A 363
TYR A 248
VAL A 247
LEU A 273
 None
 1.22A 2rctA-4hkaA:
undetectable		 2rctA-4hkaA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i67 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		no annotation 5 ALA A 491
ARG A 436
VAL A 483
LEU A 475
LEU A 445
 None
 1.24A 2rctA-4i67A:
undetectable		 2rctA-4i67A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvs RAS-RELATED PROTEIN
RAB-1A

(Homo sapiens) 		PF00071
(Ras) 		5 ILE B 148
TYR B  91
VAL B  93
LEU B 121
LEU B  27
 None
 1.00A 2rctA-4jvsB:
undetectable		 2rctA-4jvsB:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmp SIALIC ACID BINDING
PROTEIN

(Pasteurella
multocida) 		PF03480
(DctP) 		5 ILE A  89
ALA A  98
TYR A 125
VAL A 252
LEU A 213
 None
 1.33A 2rctA-4mmpA:
undetectable		 2rctA-4mmpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		5 ILE A  34
ALA A 322
VAL A  49
LEU A  36
LEU A 247
 None
 1.08A 2rctA-4nz5A:
undetectable		 2rctA-4nz5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyy CUTINASE

(Humicola
insolens) 		PF01083
(Cutinase) 		5 ILE A 144
ALA A 114
VAL A  38
LEU A 131
LEU A  22
 None
 1.28A 2rctA-4oyyA:
undetectable		 2rctA-4oyyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 200
ILE A 216
ALA A 221
LEU A 192
LEU A 161
 None
 1.30A 2rctA-4r5cA:
undetectable		 2rctA-4r5cA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 ALA A 158
THR A 165
VAL A 392
LEU A 106
LEU A 353
 None
 1.29A 2rctA-4txaA:
undetectable		 2rctA-4txaA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Homo sapiens;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 PHE A 106
ILE A 128
ALA A  41
VAL A  18
LEU A 130
 None
 1.36A 2rctA-4x5tA:
undetectable		 2rctA-4x5tA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7m TYPE VI SECRETION
PROTEIN ICMF

(Escherichia
coli) 		PF06744
(IcmF_C) 		5 MET C1053
ALA C1039
THR C 996
ARG C1049
LEU C 981
 None
 1.28A 2rctA-4y7mC:
undetectable		 2rctA-4y7mC:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ILE A 168
THR A 105
VAL A  42
LEU A 158
LEU A  80
 None
ADP  A 506 ( 4.6A)
ADP  A 506 (-4.3A)
ADP  A 506 (-4.7A)
None
 1.38A 2rctA-4ysjA:
undetectable		 2rctA-4ysjA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 ILE A 156
TYR A 100
VAL A 102
LEU A 130
LEU A  36
 None
 0.88A 2rctA-4z8yA:
undetectable		 2rctA-4z8yA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs7 LLAMA FAB FRAGMENT
68F2 HEAVY CHAIN
LLAMA FAB FRAGMENT
68F2 LIGHT CHAIN

(Lama glama;
Lama glama) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE L  50
ALA L  73
TYR L  88
GLN H  41
LEU H  47
 None
 1.13A 2rctA-4zs7L:
undetectable		 2rctA-4zs7L:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a15 BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD16

(Homo sapiens) 		PF02214
(BTB_2) 		5 PHE A  55
THR A  38
ARG A  72
TYR A  36
LEU A  89
 None
 1.38A 2rctA-5a15A:
undetectable		 2rctA-5a15A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		5 ILE J 284
ALA J 300
THR J 335
TYR J 332
LEU J 285
 None
 1.35A 2rctA-5afuJ:
undetectable		 2rctA-5afuJ:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 PHE A1407
MET A1365
ILE A1368
ALA A1423
LEU A1357
 None
 1.33A 2rctA-5cslA:
0.2		 2rctA-5cslA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		5 ILE B 229
TYR B 181
VAL B 185
LEU B 232
LEU B 201
 None
 1.23A 2rctA-5fn3B:
undetectable		 2rctA-5fn3B:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 0.99A 2rctA-5iq6A:
undetectable		 2rctA-5iq6A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 1.01A 2rctA-5jjrA:
undetectable		 2rctA-5jjrA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyu TWO-COMPONENT SENSOR
HISTIDINE KINASE

(Thermosynechococcus
elongatus) 		no annotation 5 PHE A 713
ILE A 616
THR A 625
LEU A 618
LEU A 706
 None
 1.24A 2rctA-5jyuA:
undetectable		 2rctA-5jyuA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 1.02A 2rctA-5k5mA:
undetectable		 2rctA-5k5mA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 PHE A 198
VAL A  47
LEU A 123
GLN A 207
LEU A 203
 None
 1.34A 2rctA-5lx8A:
undetectable		 2rctA-5lx8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mao HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		no annotation 5 ALA A 491
ARG A 436
VAL A 483
LEU A 475
LEU A 445
 None
 1.06A 2rctA-5maoA:
undetectable		 2rctA-5maoA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		5 PHE A  47
ALA A  93
THR A  54
VAL A  59
LEU A 310
 None
 1.31A 2rctA-5ncsA:
undetectable		 2rctA-5ncsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		5 PHE A   8
ALA A  54
THR A  15
VAL A  20
LEU A 271
 None
 1.31A 2rctA-5ncwA:
undetectable		 2rctA-5ncwA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 PHE A 336
ILE A 317
ALA A 291
LEU A 318
LEU A 377
 None
 1.34A 2rctA-5oljA:
undetectable		 2rctA-5oljA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 5 PHE A 105
ILE A 127
ALA A  40
VAL A  17
LEU A 129
 None
 1.38A 2rctA-5osbA:
undetectable		 2rctA-5osbA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 PHE A 412
ALA A 411
THR A 516
LEU A 404
LEU A 471
 None
 1.36A 2rctA-5t8vA:
undetectable		 2rctA-5t8vA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf2 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Neisseria
gonorrhoeae) 		PF06026
(Rib_5-P_isom_A) 		5 PHE A  36
ALA A  15
TYR A  80
VAL A 107
LEU A  61
 None
 1.23A 2rctA-5uf2A:
undetectable		 2rctA-5uf2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE
MDCD

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF06833
(MdcE)
PF01039
(Carboxyl_trans) 		5 ILE B  93
ALA B 139
VAL B 173
LEU B 114
GLN A 113
 None
 1.31A 2rctA-5vipB:
undetectable		 2rctA-5vipB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vws CYTOCHROME P450

(Thermobispora
bispora) 		PF00067
(p450) 		5 PHE A 333
ALA A 332
THR A 235
LEU A 267
LEU A 345
 HEM  A 401 (-3.8A)
HEM  A 401 (-4.1A)
HEM  A 401 ( 3.9A)
None
HEM  A 401 (-3.8A)
 1.08A 2rctA-5vwsA:
undetectable		 2rctA-5vwsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*

(unidentified) 		no annotation 5 PHE A 133
ILE A 160
THR A 188
VAL A  83
LEU A 116
 None
 1.19A 2rctA-5wl7A:
undetectable		 2rctA-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE A 236
ALA A 211
VAL A 252
LEU A 240
LEU A 130
 None
 1.34A 2rctA-5wy3A:
undetectable		 2rctA-5wy3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 PHE A 248
ILE A 259
ALA A 275
THR A 242
LEU A 207
 None
 1.39A 2rctA-5x2qA:
undetectable		 2rctA-5x2qA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00001
(7tm_1)
PF00258
(Flavodoxin_1) 		5 ALA A1038
THR A1081
ARG A1036
LEU A1005
LEU A1112
 None
 1.16A 2rctA-5xraA:
undetectable		 2rctA-5xraA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 ILE A 287
ALA A 329
THR A 338
VAL A 181
LEU A 184
 None
 1.21A 2rctA-5yl7A:
undetectable		 2rctA-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0n PGV19 FAB HEAVY
CHAIN
PGV19 LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 ILE E  48
TYR E  86
LEU E  47
GLN D  39
LEU D  45
 None
 1.39A 2rctA-6b0nE:
undetectable		 2rctA-6b0nE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c33 5'-3' EXONUCLEASE

(Mycolicibacterium
smegmatis) 		no annotation 5 PHE A  39
ILE A 114
VAL A 141
LEU A  55
LEU A 166
 None
 1.27A 2rctA-6c33A:
undetectable		 2rctA-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c33 5'-3' EXONUCLEASE

(Mycolicibacterium
smegmatis) 		no annotation 5 PHE A  39
ILE A 114
VAL A 141
LEU A  55
LEU A 170
 None
 1.11A 2rctA-6c33A:
undetectable		 2rctA-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d72 SPERMIDINE
N1-ACETYLTRANSFERASE

(Yersinia pestis) 		no annotation 5 ILE A  62
ALA A 102
VAL A 114
LEU A   9
LEU A 120
 None
 1.15A 2rctA-6d72A:
undetectable		 2rctA-6d72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 5 PHE A 195
TYR A 131
VAL A 132
LEU A 405
LEU A  42
 None
 1.23A 2rctA-6dk2A:
undetectable		 2rctA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A2316
ILE A2331
ALA A2455
LYS A2272
VAL A2345
 None
 1.31A 2rctA-6emkA:
undetectable		 2rctA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 5 ILE A 244
ALA A 214
THR A 157
VAL A 183
GLN A 164
 None
 1.31A 2rctA-6frvA:
undetectable		 2rctA-6frvA:
undetectable