SIMILAR PATTERNS OF AMINO ACIDS FOR 2RCT_A_RTLA140

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aua PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
SEC14P

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 MET A  75
ALA A  64
ARG A  60
TYR A 205
VAL A 148
 None
BOG  A   1 ( 4.5A)
None
None
None
 1.10A 2rctA-1auaA:
undetectable		 2rctA-1auaA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link) 		5 MET A 181
ILE A 194
ALA A 199
VAL A 186
LEU A 183
 None
 1.21A 2rctA-1c9lA:
undetectable		 2rctA-1c9lA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 ILE A 374
ALA A 358
TYR A 381
LEU A 377
LEU A 302
 None
 1.32A 2rctA-1crlA:
0.0		 2rctA-1crlA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 PHE C 338
ALA C 239
ARG C 323
TYR C 350
VAL C 128
 None
 1.36A 2rctA-1ea9C:
0.0		 2rctA-1ea9C:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 PHE A 297
MET A 329
ALA A 293
VAL A 366
LEU A 377
 None
 1.10A 2rctA-1fc9A:
0.0		 2rctA-1fc9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ILE A 131
ALA A 129
TYR A 105
LEU A 148
GLN A 360
 None
 1.26A 2rctA-1fcpA:
0.8		 2rctA-1fcpA:
11.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		7 ILE A  25
ALA A  33
LYS A  40
THR A  53
TYR A  60
VAL A  62
LEU A 117
 None
 0.79A 2rctA-1gglA:
23.1		 2rctA-1gglA:
49.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LYS A  40
THR A  53
ARG A  58
TYR A  60
VAL A  62
LEU A 117
 None
 0.99A 2rctA-1gglA:
23.1		 2rctA-1gglA:
49.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		5 ALA A 178
THR A 156
TYR A 159
LEU A 172
LEU A 212
 None
 1.19A 2rctA-1ixpA:
undetectable		 2rctA-1ixpA:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		8 ILE A  25
ALA A  33
LYS A  40
THR A  53
VAL A  62
LEU A  77
GLN A 108
LEU A 117
 None
 1.11A 2rctA-1kqxA:
24.7		 2rctA-1kqxA:
72.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		9 PHE A  16
MET A  20
ILE A  25
ALA A  33
LYS A  40
THR A  53
VAL A  62
GLN A 108
LEU A 117
 None
 0.64A 2rctA-1kqxA:
24.7		 2rctA-1kqxA:
72.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lpj RETINOL-BINDING
PROTEIN IV, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		10 PHE A  16
MET A  20
ILE A  25
ALA A  33
LYS A  40
THR A  53
ARG A  58
VAL A  62
LEU A  77
LEU A 117
 None
 0.84A 2rctA-1lpjA:
24.8		 2rctA-1lpjA:
56.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		5 ILE A 601
ALA A 361
LEU A 356
GLN A 407
LEU A 403
 None
 1.09A 2rctA-1uf2A:
undetectable		 2rctA-1uf2A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		5 ILE A 347
ALA A 210
THR A 128
LEU A 344
LEU A 104
 None
 1.16A 2rctA-1vgmA:
undetectable		 2rctA-1vgmA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1s RAS-RELATED PROTEIN
M-RAS

(Mus musculus) 		PF00071
(Ras) 		5 ILE A 150
TYR A  92
VAL A  94
LEU A 123
LEU A  29
 None
 0.92A 2rctA-1x1sA:
undetectable		 2rctA-1x1sA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3j RNA AND EXPORT
FACTOR BINDING
PROTEIN 2

(Mus musculus) 		PF00076
(RRM_1)
PF07078
(FYTT) 		5 ALA A 151
VAL A 106
LEU A  78
GLN A  92
LEU A 101
 None
 1.22A 2rctA-2f3jA:
undetectable		 2rctA-2f3jA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 PHE A  16
ALA A  14
ARG A  11
VAL A 300
LEU A 555
 None
 1.20A 2rctA-2fonA:
undetectable		 2rctA-2fonA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		5 MET A 362
ALA A 336
LEU A 329
GLN A 227
LEU A 266
 None
 1.36A 2rctA-2i9uA:
undetectable		 2rctA-2i9uA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsj DNA REPAIR PROTEIN
REV1

(Mus musculus) 		PF16727
(REV1_C) 		5 MET A  85
ILE A  44
ALA A  96
LEU A  40
LEU A 116
 None
 1.10A 2rctA-2lsjA:
undetectable		 2rctA-2lsjA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 MET A  32
ILE A 360
ALA A 372
VAL A 291
LEU A 362
 None
 1.31A 2rctA-2o1bA:
undetectable		 2rctA-2o1bA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og7 ASPARAGINE OXYGENASE

(Streptomyces
coelicolor) 		PF02668
(TauD) 		5 PHE A 208
VAL A 191
LEU A 229
GLN A 260
LEU A 242
 None
 1.34A 2rctA-2og7A:
undetectable		 2rctA-2og7A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 PHE A 167
ALA A 230
THR A  15
TYR A  13
LEU A  48
 None
 1.39A 2rctA-2ohhA:
undetectable		 2rctA-2ohhA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pft EXOCYTOSIS PROTEIN

(Mus musculus) 		PF03081
(Exo70) 		5 ALA A 440
TYR A 466
VAL A 470
LEU A 394
LEU A 432
 None
 1.28A 2rctA-2pftA:
undetectable		 2rctA-2pftA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 ILE A 301
ALA A 236
ARG A 237
LEU A 250
LEU A 273
 None
 1.32A 2rctA-2q8hA:
undetectable		 2rctA-2q8hA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 300
ALA A 193
THR A 185
TYR A 186
LEU A 219
 None
None
None
GOL  A 601 ( 4.5A)
None
 1.33A 2rctA-2q9gA:
undetectable		 2rctA-2q9gA:
15.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		11 PHE A  16
MET A  20
ILE A  25
ALA A  33
LYS A  40
THR A  53
ARG A  58
VAL A  62
LEU A  77
GLN A 108
LEU A 117
 None
None
None
None
None
None
SO4  A 152 (-3.1A)
None
None
None
None
 0.49A 2rctA-2rcqA:
29.6		 2rctA-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhd SMALL GTP BINDING
PROTEIN RAB1A

(Cryptosporidium
parvum) 		PF00071
(Ras) 		5 ILE A 146
TYR A  89
VAL A  91
LEU A 119
LEU A  25
 None
 0.92A 2rctA-2rhdA:
undetectable		 2rctA-2rhdA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		5 PHE A  26
ALA A  98
THR A 149
ARG A 145
LEU A  39
 None
GOL  A1302 (-3.1A)
None
None
None
 1.36A 2rctA-2vg2A:
undetectable		 2rctA-2vg2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 PHE A 845
ILE A 856
THR A 820
LEU A 832
LEU A 824
 None
 1.24A 2rctA-2wfhA:
undetectable		 2rctA-2wfhA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		5 PHE A 596
ALA A 593
TYR A 553
VAL A 527
LEU A 602
 None
 1.30A 2rctA-2yhgA:
undetectable		 2rctA-2yhgA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 ILE A 222
ALA A 164
THR A 114
VAL A 139
LEU A  51
 UNL  A 420 (-4.1A)
UNL  A 420 (-3.6A)
None
None
None
 1.25A 2rctA-3b9yA:
undetectable		 2rctA-3b9yA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		5 ILE A 380
ALA A 432
VAL A 400
LEU A 391
LEU A 352
 None
 1.00A 2rctA-3bc8A:
undetectable		 2rctA-3bc8A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cph RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 ILE A 156
TYR A 100
VAL A 102
LEU A 130
LEU A  36
 None
 0.91A 2rctA-3cphA:
undetectable		 2rctA-3cphA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpr DIHYDRODIPICOLINATE
SYNTHETASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 MET A  24
ALA A  43
VAL A 303
LEU A 269
LEU A 227
 None
 1.31A 2rctA-3cprA:
undetectable		 2rctA-3cprA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0q PROTEIN CALG3

(Micromonospora
echinospora) 		PF06722
(DUF1205) 		5 PHE A 174
MET A 291
ILE A 294
ARG A 321
GLN A 311
 None
 1.34A 2rctA-3d0qA:
undetectable		 2rctA-3d0qA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		5 ILE A 244
ALA A 214
THR A 157
VAL A 183
GLN A 164
 None
 1.32A 2rctA-3eqaA:
undetectable		 2rctA-3eqaA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		PF00616
(RasGAP) 		5 PHE A1058
ALA A1013
TYR A1158
VAL A1272
LEU A1023
 None
 1.39A 2rctA-3fayA:
undetectable		 2rctA-3fayA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		5 ILE A 235
ARG A 420
VAL A 417
GLN A 440
LEU A 436
 None
 1.31A 2rctA-3gjuA:
undetectable		 2rctA-3gjuA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 PHE A 234
MET A 233
ILE A 228
ALA A 256
GLN A 386
 None
 1.39A 2rctA-3js8A:
undetectable		 2rctA-3js8A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8i 30KLP

(Treponema
pallidum) 		no annotation 5 ILE A  62
ARG A  61
TYR A 225
LEU A  58
LEU A 216
 None
 1.26A 2rctA-3k8iA:
undetectable		 2rctA-3k8iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke2 UNCHARACTERIZED
PROTEIN YP_928783.1

(Shewanella
amazonensis) 		PF09904
(HTH_43) 		5 PHE A  56
ALA A  52
ARG A  20
TYR A  23
VAL A  94
 None
 1.24A 2rctA-3ke2A:
undetectable		 2rctA-3ke2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktd PREPHENATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF02153
(PDH) 		5 MET A  77
ILE A  80
ALA A 105
THR A 149
VAL A 170
 None
 1.38A 2rctA-3ktdA:
undetectable		 2rctA-3ktdA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 211
ARG A 187
VAL A 151
LEU A 186
GLN A 145
 None
 1.29A 2rctA-3kumA:
undetectable		 2rctA-3kumA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvn UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MEDO-DIAMINOP
IMELATE LIGASE

([Haemophilus]
ducreyi) 		PF02875
(Mur_ligase_C) 		5 ILE A 344
ALA A 334
VAL A 398
LEU A 380
LEU A 418
 None
 1.39A 2rctA-3mvnA:
undetectable		 2rctA-3mvnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pft FLAVIN REDUCTASE

(Mycolicibacterium
goodii) 		PF01613
(Flavin_Reduct) 		5 PHE A  53
ILE A  73
ALA A  38
LEU A  71
LEU A 124
 None
None
FMN  A 401 (-3.5A)
None
None
 1.11A 2rctA-3pftA:
undetectable		 2rctA-3pftA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puf RIBONUCLEASE H2
SUBUNIT B

(Homo sapiens) 		PF09468
(RNase_H2-Ydr279) 		5 ALA B 104
THR B 142
TYR B 156
LEU B 113
LEU B  94
 None
 1.22A 2rctA-3pufB:
undetectable		 2rctA-3pufB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 ILE A 283
ALA A 197
TYR A 205
VAL A 209
LEU A 279
 None
 1.26A 2rctA-3s1sA:
undetectable		 2rctA-3s1sA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slu M23 PEPTIDASE DOMAIN
PROTEIN

(Neisseria
meningitidis) 		PF01551
(Peptidase_M23) 		5 PHE A 190
ILE A 224
ALA A 238
LEU A 207
LEU A 199
 None
 1.31A 2rctA-3sluA:
undetectable		 2rctA-3sluA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 RAS-RELATED PROTEIN
RAB-35

(Homo sapiens) 		PF00071
(Ras) 		5 ILE B 144
TYR B  88
VAL B  90
LEU B 117
LEU B  24
 None
 0.96A 2rctA-3tw8B:
undetectable		 2rctA-3tw8B:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 ALA A 498
ARG A 465
VAL A 458
LEU A 461
LEU A 369
 None
 1.38A 2rctA-3v4oA:
undetectable		 2rctA-3v4oA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
MET A  20
ALA A  33
THR A  53
LEU A 115
 2AN  A 201 ( 4.9A)
2AN  A 201 ( 3.9A)
2AN  A 201 (-3.8A)
2AN  A 201 ( 4.0A)
None
 0.73A 2rctA-3wbgA:
20.2		 2rctA-3wbgA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdb PROTEIN XNI

(Escherichia
coli) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		5 PHE A  88
ALA A  47
TYR A 143
LEU A  36
GLN A  21
 None
None
ACT  A1254 ( 4.9A)
ACT  A1254 (-4.8A)
None
 1.33A 2rctA-3zdbA:
undetectable		 2rctA-3zdbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 PHE A 608
ILE A 799
ALA A 640
LEU A 795
LEU A 590
 None
 1.38A 2rctA-3zuqA:
undetectable		 2rctA-3zuqA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster) 		no annotation 5 ALA A 406
THR A 572
ARG A 423
LEU A 469
GLN A 431
 None
None
AN2  A1788 (-2.8A)
None
None
 1.36A 2rctA-4bwpA:
undetectable		 2rctA-4bwpA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 ILE A 551
ALA A 572
VAL A 787
LEU A 549
LEU A 221
 None
 1.29A 2rctA-4ci8A:
undetectable		 2rctA-4ci8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 MET A 252
ILE A 282
ALA A 266
VAL A 346
LEU A 387
 None
 1.19A 2rctA-4e4gA:
undetectable		 2rctA-4e4gA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2p CHAPERONE SURA

(Salmonella
enterica) 		PF13616
(Rotamase_3) 		5 PHE A 321
ILE A 310
ALA A 325
LEU A 307
LEU A 360
 None
 1.13A 2rctA-4g2pA:
undetectable		 2rctA-4g2pA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		5 PHE A 206
ILE A 363
TYR A 248
VAL A 247
LEU A 273
 None
 1.22A 2rctA-4hkaA:
undetectable		 2rctA-4hkaA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i67 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		no annotation 5 ALA A 491
ARG A 436
VAL A 483
LEU A 475
LEU A 445
 None
 1.24A 2rctA-4i67A:
undetectable		 2rctA-4i67A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvs RAS-RELATED PROTEIN
RAB-1A

(Homo sapiens) 		PF00071
(Ras) 		5 ILE B 148
TYR B  91
VAL B  93
LEU B 121
LEU B  27
 None
 1.00A 2rctA-4jvsB:
undetectable		 2rctA-4jvsB:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmp SIALIC ACID BINDING
PROTEIN

(Pasteurella
multocida) 		PF03480
(DctP) 		5 ILE A  89
ALA A  98
TYR A 125
VAL A 252
LEU A 213
 None
 1.33A 2rctA-4mmpA:
undetectable		 2rctA-4mmpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		5 ILE A  34
ALA A 322
VAL A  49
LEU A  36
LEU A 247
 None
 1.08A 2rctA-4nz5A:
undetectable		 2rctA-4nz5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyy CUTINASE

(Humicola
insolens) 		PF01083
(Cutinase) 		5 ILE A 144
ALA A 114
VAL A  38
LEU A 131
LEU A  22
 None
 1.28A 2rctA-4oyyA:
undetectable		 2rctA-4oyyA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 200
ILE A 216
ALA A 221
LEU A 192
LEU A 161
 None
 1.30A 2rctA-4r5cA:
undetectable		 2rctA-4r5cA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 ALA A 158
THR A 165
VAL A 392
LEU A 106
LEU A 353
 None
 1.29A 2rctA-4txaA:
undetectable		 2rctA-4txaA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN

(Homo sapiens;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 PHE A 106
ILE A 128
ALA A  41
VAL A  18
LEU A 130
 None
 1.36A 2rctA-4x5tA:
undetectable		 2rctA-4x5tA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7m TYPE VI SECRETION
PROTEIN ICMF

(Escherichia
coli) 		PF06744
(IcmF_C) 		5 MET C1053
ALA C1039
THR C 996
ARG C1049
LEU C 981
 None
 1.28A 2rctA-4y7mC:
undetectable		 2rctA-4y7mC:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ILE A 168
THR A 105
VAL A  42
LEU A 158
LEU A  80
 None
ADP  A 506 ( 4.6A)
ADP  A 506 (-4.3A)
ADP  A 506 (-4.7A)
None
 1.38A 2rctA-4ysjA:
undetectable		 2rctA-4ysjA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 ILE A 156
TYR A 100
VAL A 102
LEU A 130
LEU A  36
 None
 0.88A 2rctA-4z8yA:
undetectable		 2rctA-4z8yA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs7 LLAMA FAB FRAGMENT
68F2 HEAVY CHAIN
LLAMA FAB FRAGMENT
68F2 LIGHT CHAIN

(Lama glama;
Lama glama) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE L  50
ALA L  73
TYR L  88
GLN H  41
LEU H  47
 None
 1.13A 2rctA-4zs7L:
undetectable		 2rctA-4zs7L:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a15 BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD16

(Homo sapiens) 		PF02214
(BTB_2) 		5 PHE A  55
THR A  38
ARG A  72
TYR A  36
LEU A  89
 None
 1.38A 2rctA-5a15A:
undetectable		 2rctA-5a15A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afu DYNACTIN

(Sus scrofa) 		PF00022
(Actin) 		5 ILE J 284
ALA J 300
THR J 335
TYR J 332
LEU J 285
 None
 1.35A 2rctA-5afuJ:
undetectable		 2rctA-5afuJ:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 PHE A1407
MET A1365
ILE A1368
ALA A1423
LEU A1357
 None
 1.33A 2rctA-5cslA:
0.2		 2rctA-5cslA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		5 ILE B 229
TYR B 181
VAL B 185
LEU B 232
LEU B 201
 None
 1.23A 2rctA-5fn3B:
undetectable		 2rctA-5fn3B:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 0.99A 2rctA-5iq6A:
undetectable		 2rctA-5iq6A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 1.01A 2rctA-5jjrA:
undetectable		 2rctA-5jjrA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyu TWO-COMPONENT SENSOR
HISTIDINE KINASE

(Thermosynechococcus
elongatus) 		no annotation 5 PHE A 713
ILE A 616
THR A 625
LEU A 618
LEU A 706
 None
 1.24A 2rctA-5jyuA:
undetectable		 2rctA-5jyuA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 1.02A 2rctA-5k5mA:
undetectable		 2rctA-5k5mA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 PHE A 198
VAL A  47
LEU A 123
GLN A 207
LEU A 203
 None
 1.34A 2rctA-5lx8A:
undetectable		 2rctA-5lx8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mao HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		no annotation 5 ALA A 491
ARG A 436
VAL A 483
LEU A 475
LEU A 445
 None
 1.06A 2rctA-5maoA:
undetectable		 2rctA-5maoA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		5 PHE A  47
ALA A  93
THR A  54
VAL A  59
LEU A 310
 None
 1.31A 2rctA-5ncsA:
undetectable		 2rctA-5ncsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		5 PHE A   8
ALA A  54
THR A  15
VAL A  20
LEU A 271
 None
 1.31A 2rctA-5ncwA:
undetectable		 2rctA-5ncwA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 PHE A 336
ILE A 317
ALA A 291
LEU A 318
LEU A 377
 None
 1.34A 2rctA-5oljA:
undetectable		 2rctA-5oljA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 5 PHE A 105
ILE A 127
ALA A  40
VAL A  17
LEU A 129
 None
 1.38A 2rctA-5osbA:
undetectable		 2rctA-5osbA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 PHE A 412
ALA A 411
THR A 516
LEU A 404
LEU A 471
 None
 1.36A 2rctA-5t8vA:
undetectable		 2rctA-5t8vA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf2 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Neisseria
gonorrhoeae) 		PF06026
(Rib_5-P_isom_A) 		5 PHE A  36
ALA A  15
TYR A  80
VAL A 107
LEU A  61
 None
 1.23A 2rctA-5uf2A:
undetectable		 2rctA-5uf2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE
MDCD

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF06833
(MdcE)
PF01039
(Carboxyl_trans) 		5 ILE B  93
ALA B 139
VAL B 173
LEU B 114
GLN A 113
 None
 1.31A 2rctA-5vipB:
undetectable		 2rctA-5vipB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vws CYTOCHROME P450

(Thermobispora
bispora) 		PF00067
(p450) 		5 PHE A 333
ALA A 332
THR A 235
LEU A 267
LEU A 345
 HEM  A 401 (-3.8A)
HEM  A 401 (-4.1A)
HEM  A 401 ( 3.9A)
None
HEM  A 401 (-3.8A)
 1.08A 2rctA-5vwsA:
undetectable		 2rctA-5vwsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*

(unidentified) 		no annotation 5 PHE A 133
ILE A 160
THR A 188
VAL A  83
LEU A 116
 None
 1.19A 2rctA-5wl7A:
undetectable		 2rctA-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 ILE A 236
ALA A 211
VAL A 252
LEU A 240
LEU A 130
 None
 1.34A 2rctA-5wy3A:
undetectable		 2rctA-5wy3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 PHE A 248
ILE A 259
ALA A 275
THR A 242
LEU A 207
 None
 1.39A 2rctA-5x2qA:
undetectable		 2rctA-5x2qA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00001
(7tm_1)
PF00258
(Flavodoxin_1) 		5 ALA A1038
THR A1081
ARG A1036
LEU A1005
LEU A1112
 None
 1.16A 2rctA-5xraA:
undetectable		 2rctA-5xraA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 ILE A 287
ALA A 329
THR A 338
VAL A 181
LEU A 184
 None
 1.21A 2rctA-5yl7A:
undetectable		 2rctA-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0n PGV19 FAB HEAVY
CHAIN
PGV19 LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 ILE E  48
TYR E  86
LEU E  47
GLN D  39
LEU D  45
 None
 1.39A 2rctA-6b0nE:
undetectable		 2rctA-6b0nE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c33 5'-3' EXONUCLEASE

(Mycolicibacterium
smegmatis) 		no annotation 5 PHE A  39
ILE A 114
VAL A 141
LEU A  55
LEU A 166
 None
 1.27A 2rctA-6c33A:
undetectable		 2rctA-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c33 5'-3' EXONUCLEASE

(Mycolicibacterium
smegmatis) 		no annotation 5 PHE A  39
ILE A 114
VAL A 141
LEU A  55
LEU A 170
 None
 1.11A 2rctA-6c33A:
undetectable		 2rctA-6c33A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d72 SPERMIDINE
N1-ACETYLTRANSFERASE

(Yersinia pestis) 		no annotation 5 ILE A  62
ALA A 102
VAL A 114
LEU A   9
LEU A 120
 None
 1.15A 2rctA-6d72A:
undetectable		 2rctA-6d72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 5 PHE A 195
TYR A 131
VAL A 132
LEU A 405
LEU A  42
 None
 1.23A 2rctA-6dk2A:
undetectable		 2rctA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A2316
ILE A2331
ALA A2455
LYS A2272
VAL A2345
 None
 1.31A 2rctA-6emkA:
undetectable		 2rctA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 5 ILE A 244
ALA A 214
THR A 157
VAL A 183
GLN A 164
 None
 1.31A 2rctA-6frvA:
undetectable		 2rctA-6frvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3n PROTEIN (KETOACYL
ACYL CARRIER PROTEIN
SYNTHASE 2)

(Escherichia
coli) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 GLN A  31
THR A 334
TRP A  24
 None
 0.86A 2rctA-1b3nA:
0.0		 2rctA-1b3nA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLN A 293
THR A 451
TRP A 226
 None
 0.90A 2rctA-1ciyA:
0.0		 2rctA-1ciyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggv DIENELACTONE
HYDROLASE

(Pseudomonas
putida) 		PF01738
(DLH) 		3 GLN A 232
THR A 224
TRP A  50
 None
 1.09A 2rctA-1ggvA:
0.0		 2rctA-1ggvA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		3 GLN A 115
THR A 304
TRP A  79
 None
HEM  A 800 (-3.4A)
None
 1.09A 2rctA-1itkA:
0.0		 2rctA-1itkA:
11.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kqx CELLULAR
RETINOL-BINDING
PROTEIN

(Danio rerio) 		PF00061
(Lipocalin) 		3 GLN A  38
THR A  51
TRP A 106
 None
 0.17A 2rctA-1kqxA:
24.7		 2rctA-1kqxA:
72.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3g DUAL SPECIFICITY
PROTEIN PHOSPHATASE
2

(Homo sapiens) 		PF00782
(DSPc) 		3 GLN A 310
THR A 266
TRP A 235
 None
 1.02A 2rctA-1m3gA:
0.0		 2rctA-1m3gA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		3 GLN A 353
THR A 638
TRP A 562
 None
 0.83A 2rctA-1n76A:
0.0		 2rctA-1n76A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 GLN A 157
THR A  92
TRP A 187
 None
 1.12A 2rctA-1ryyA:
0.0		 2rctA-1ryyA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 GLN A 197
THR A 336
TRP A 412
 None
 1.15A 2rctA-1suvA:
undetectable		 2rctA-1suvA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv6 2-KETO-4-PENTENOATE
HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 GLN A  71
THR A 154
TRP A 147
 None
 1.18A 2rctA-1sv6A:
undetectable		 2rctA-1sv6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		3 GLN C 181
THR C  97
TRP C  93
 None
 1.00A 2rctA-1w36C:
undetectable		 2rctA-1w36C:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		3 GLN A 197
THR A 122
TRP A 282
 None
 1.12A 2rctA-1wkyA:
undetectable		 2rctA-1wkyA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsj RIBONUCLEASE HI

(Escherichia
coli) 		PF00075
(RNase_H) 		3 GLN A  72
THR A   9
TRP A 118
 None
 0.95A 2rctA-1wsjA:
undetectable		 2rctA-1wsjA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		3 GLN A 517
THR A 523
TRP A 101
 None
 0.83A 2rctA-1yt8A:
undetectable		 2rctA-1yt8A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLN A 118
THR A 111
TRP A 163
 None
 0.72A 2rctA-2ag1A:
undetectable		 2rctA-2ag1A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crr STROMAL
MEMBRANE-ASSOCIATED
PROTEIN SMAP1B

(Homo sapiens) 		PF01412
(ArfGap) 		3 GLN A  86
THR A  78
TRP A  45
 None
 1.15A 2rctA-2crrA:
undetectable		 2rctA-2crrA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl5 IMMUNOGLOBULIN IGG1
HEAVY CHAIN

(Homo sapiens) 		no annotation 3 GLN H  82
THR H 107
TRP H  36
 None
 1.02A 2rctA-2fl5H:
undetectable		 2rctA-2fl5H:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLN A 222
THR A 425
TRP A 107
 None
None
CU  A 603 ( 4.4A)
 1.11A 2rctA-2hzhA:
undetectable		 2rctA-2hzhA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		3 GLN A 117
THR A  73
TRP A  18
 None
None
GOL  A 220 (-3.5A)
 1.15A 2rctA-2in3A:
undetectable		 2rctA-2in3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lll LAMIN-B2

(Homo sapiens) 		PF00932
(LTD) 		3 GLN A 467
THR A 542
TRP A 534
 None
 1.16A 2rctA-2lllA:
undetectable		 2rctA-2lllA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 GLN A 197
THR A 159
TRP A 111
 None
 1.18A 2rctA-2nq5A:
undetectable		 2rctA-2nq5A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		3 GLN A  28
THR A 297
TRP A 250
 None
 1.18A 2rctA-2qzpA:
undetectable		 2rctA-2qzpA:
12.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 GLN A  38
THR A  51
TRP A 106
 None
 0.08A 2rctA-2rcqA:
29.6		 2rctA-2rcqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whl BETA-MANNANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		3 GLN A 166
THR A  91
TRP A 251
 None
MAN  A1301 ( 4.4A)
MAN  A1301 (-4.5A)
 1.15A 2rctA-2whlA:
undetectable		 2rctA-2whlA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		3 GLN A 392
THR A 179
TRP A 416
 None
 1.07A 2rctA-2xtsA:
undetectable		 2rctA-2xtsA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqb RIBONUCLEASE HI

(Shewanella
oneidensis) 		PF00075
(RNase_H) 		3 GLN A  74
THR A  11
TRP A 120
 None
 0.95A 2rctA-2zqbA:
undetectable		 2rctA-2zqbA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 3 GLN C 201
THR C  72
TRP C 206
 None
 1.11A 2rctA-3amjC:
undetectable		 2rctA-3amjC:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 GLN A 197
THR A 186
TRP A 334
 None
 0.88A 2rctA-3bc9A:
undetectable		 2rctA-3bc9A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bze HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHA CHAIN
E

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 GLN A 226
THR A 200
TRP A 244
 None
 1.14A 2rctA-3bzeA:
undetectable		 2rctA-3bzeA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c60 TCR YAE62 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLN B  83
THR B 105
TRP B  32
 None
 1.17A 2rctA-3c60B:
undetectable		 2rctA-3c60B:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c87 ENTEROCHELIN
ESTERASE

(Shigella
flexneri) 		PF00756
(Esterase)
PF11806
(DUF3327) 		3 GLN A  64
THR A  57
TRP A  79
 None
 1.14A 2rctA-3c87A:
undetectable		 2rctA-3c87A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1

(Homo sapiens) 		PF00640
(PID) 		3 GLN A 445
THR A 474
TRP A 377
 None
 1.15A 2rctA-3d8dA:
2.1		 2rctA-3d8dA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 GLN A1178
THR A1145
TRP A1232
 None
 1.09A 2rctA-3egwA:
undetectable		 2rctA-3egwA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		3 GLN A 535
THR A 492
TRP A 453
 None
 1.16A 2rctA-3eqnA:
undetectable		 2rctA-3eqnA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		3 GLN A 122
THR A 208
TRP A 272
 None
 0.94A 2rctA-3ez1A:
undetectable		 2rctA-3ez1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1p PROTEIN PHNP

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		3 GLN A  38
THR A   6
TRP A  64
 None
 0.97A 2rctA-3g1pA:
undetectable		 2rctA-3g1pA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2n WD REPEAT-CONTAINING
PROTEIN 92

(Homo sapiens) 		PF00400
(WD40) 		3 GLN A 264
THR A 261
TRP A 168
 None
 1.03A 2rctA-3i2nA:
undetectable		 2rctA-3i2nA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu0 PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		3 GLN A 308
THR A 114
TRP A 344
 None
 1.15A 2rctA-3iu0A:
undetectable		 2rctA-3iu0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 GLN A 522
THR A 577
TRP A 512
 None
 1.12A 2rctA-3jb9A:
undetectable		 2rctA-3jb9A:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jca INTEGRASE

(Mouse mammary
tumor virus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		3 GLN A 117
THR A  84
TRP A 255
 None
 1.15A 2rctA-3jcaA:
undetectable		 2rctA-3jcaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jug BETA-MANNANASE

(Bacillus sp.
N16-5) 		PF00150
(Cellulase) 		3 GLN A 197
THR A 122
TRP A 282
 None
 1.09A 2rctA-3jugA:
undetectable		 2rctA-3jugA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		3 GLN A 457
THR A 466
TRP A 452
 None
 1.03A 2rctA-3k7dA:
undetectable		 2rctA-3k7dA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		3 GLN A  75
THR A  67
TRP A 313
 None
 1.15A 2rctA-3kkjA:
undetectable		 2rctA-3kkjA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		3 GLN B 250
THR B 695
TRP B 739
 EDO  B 900 (-2.9A)
None
None
 0.81A 2rctA-3l91B:
undetectable		 2rctA-3l91B:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		3 GLN B 699
THR B 405
TRP B 378
 None
None
EDO  B 915 ( 3.5A)
 0.88A 2rctA-3l91B:
undetectable		 2rctA-3l91B:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msg INTRA-CELLULAR
XYLANASE IXT6

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		3 GLN A  30
THR A 289
TRP A 291
 None
None
XYP  A 450 ( 4.1A)
 1.07A 2rctA-3msgA:
undetectable		 2rctA-3msgA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF00740
(Parvo_coat) 		3 GLN A 507
THR A 491
TRP A 475
 None
 1.08A 2rctA-3nttA:
undetectable		 2rctA-3nttA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF)
PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		3 GLN B 114
THR B 154
TRP A 155
 None
 1.09A 2rctA-3ojyB:
undetectable		 2rctA-3ojyB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p01 TWO-COMPONENT
RESPONSE REGULATOR

(Nostoc sp. PCC
7120) 		PF13185
(GAF_2) 		3 GLN A 210
THR A 229
TRP A 222
 None
 0.96A 2rctA-3p01A:
undetectable		 2rctA-3p01A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2c PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		3 GLN A 145
THR A 106
TRP A 462
 None
 1.11A 2rctA-3p2cA:
undetectable		 2rctA-3p2cA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		3 GLN A 192
THR A  65
TRP A 189
 None
 1.10A 2rctA-3pvcA:
undetectable		 2rctA-3pvcA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 GLN A 152
THR A  94
TRP A 119
 None
 1.17A 2rctA-3qlbA:
3.0		 2rctA-3qlbA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rzv STAM-BINDING PROTEIN

(Homo sapiens) 		PF01398
(JAB) 		3 GLN A 323
THR A 313
TRP A 333
 None
 0.99A 2rctA-3rzvA:
undetectable		 2rctA-3rzvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		3 GLN B 741
THR B 653
TRP B 649
 None
 1.05A 2rctA-3s4wB:
undetectable		 2rctA-3s4wB:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLN A  30
THR A 330
TRP A 289
 None
PG4  A 372 ( 4.0A)
None
 1.04A 2rctA-3tcsA:
undetectable		 2rctA-3tcsA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE

(Mycolicibacterium
thermoresistibile) 		PF03308
(ArgK) 		3 GLN A 256
THR A 168
TRP A 248
 None
 1.18A 2rctA-3tk1A:
undetectable		 2rctA-3tk1A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		3 GLN A 160
THR A 358
TRP A 124
 None
HEM  A1500 (-3.3A)
None
 1.07A 2rctA-3ut2A:
undetectable		 2rctA-3ut2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		3 GLN A 192
THR A 422
TRP A 466
 None
 1.08A 2rctA-3wmyA:
undetectable		 2rctA-3wmyA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpw POMB

(Vibrio
alginolyticus) 		PF00691
(OmpA) 		3 GLN A 250
THR A 231
TRP A 245
 None
 1.19A 2rctA-3wpwA:
undetectable		 2rctA-3wpwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsu BETA-MANNANASE

(Streptomyces
thermolilacinus) 		PF00150
(Cellulase) 		3 GLN A 217
THR A 139
TRP A 303
 None
 1.18A 2rctA-3wsuA:
undetectable		 2rctA-3wsuA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		3 GLN A 114
THR A 307
TRP A  78
 None
HEM  A 801 ( 3.3A)
None
 1.14A 2rctA-3wxoA:
undetectable		 2rctA-3wxoA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 GLN A  54
THR A 103
TRP A 109
 None
 0.97A 2rctA-4aieA:
undetectable		 2rctA-4aieA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		3 GLN A  96
THR A 122
TRP A 207
 None
 1.18A 2rctA-4aweA:
undetectable		 2rctA-4aweA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		3 GLN A 361
THR A 354
TRP A 349
 EDO  A1502 (-4.3A)
EDO  A1500 (-3.0A)
NGO  A1495 ( 3.4A)
 1.13A 2rctA-4c7gA:
undetectable		 2rctA-4c7gA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 3 GLN D  32
THR D 336
TRP D  25
 None
 0.97A 2rctA-4jrmD:
undetectable		 2rctA-4jrmD:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly4 PEPTIDOGLYCAN
DEACETYLASE

(Helicobacter
pylori) 		PF01522
(Polysacc_deac_1) 		3 GLN A 229
THR A 245
TRP A 196
 None
 1.03A 2rctA-4ly4A:
undetectable		 2rctA-4ly4A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly7 RIBONUCLEASE H

(unidentified) 		PF00075
(RNase_H) 		3 GLN A  72
THR A   9
TRP A 118
 None
 0.94A 2rctA-4ly7A:
undetectable		 2rctA-4ly7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 3 GLN A 479
THR A 471
TRP A 381
 None
 1.18A 2rctA-4qnlA:
undetectable		 2rctA-4qnlA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 GLN A  31
THR A 334
TRP A  24
 None
 1.07A 2rctA-4r8eA:
undetectable		 2rctA-4r8eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 3 GLN A 218
THR A 596
TRP A 196
 None
BGC  A 703 (-3.5A)
BGC  A 703 (-3.7A)
 1.08A 2rctA-4tz5A:
undetectable		 2rctA-4tz5A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 GLN A 510
THR A 501
TRP A 472
 None
 1.18A 2rctA-4u33A:
undetectable		 2rctA-4u33A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		3 GLN A 172
THR A 313
TRP A 204
 None
 1.12A 2rctA-4v1uA:
undetectable		 2rctA-4v1uA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 GLN A 221
THR A 193
TRP A 200
 None
 1.10A 2rctA-4w87A:
undetectable		 2rctA-4w87A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE

(Bifidobacterium
longum) 		PF01636
(APH) 		3 GLN A  48
THR A  52
TRP A  91
 ATP  A 401 (-3.4A)
None
None
 1.08A 2rctA-4wh3A:
undetectable		 2rctA-4wh3A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 GLN A 171
THR A 194
TRP A 201
 None
None
XYL  A2015 (-3.6A)
 1.06A 2rctA-4xwhA:
undetectable		 2rctA-4xwhA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 GLN A 624
THR A 137
TRP A 103
 None
 0.96A 2rctA-4xwhA:
undetectable		 2rctA-4xwhA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 3 GLN A 395
THR A 469
TRP A 601
 None
 1.15A 2rctA-5awpA:
undetectable		 2rctA-5awpA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 GLN A  58
THR A 107
TRP A 113
 None
 0.87A 2rctA-5brqA:
undetectable		 2rctA-5brqA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 GLN A 460
THR A 772
TRP A 584
 None
MD1  A1004 (-3.8A)
MD1  A1004 (-4.2A)
 1.12A 2rctA-5chcA:
undetectable		 2rctA-5chcA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo WD REPEAT-CONTAINING
PROTEIN 48
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46

(Homo sapiens;
Homo sapiens) 		PF00400
(WD40)
PF00443
(UCH) 		3 GLN B 239
THR B 187
TRP A 256
 None
 1.15A 2rctA-5cvoB:
undetectable		 2rctA-5cvoB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dih MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		PF00936
(BMC) 		3 GLN A 100
THR A 163
TRP A 114
 None
 1.18A 2rctA-5dihA:
undetectable		 2rctA-5dihA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		3 GLN A 198
THR A 205
TRP A 102
 None
None
5O8  A 301 (-4.4A)
 1.14A 2rctA-5ei3A:
undetectable		 2rctA-5ei3A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		3 GLN A 378
THR A 439
TRP A 384
 None
None
DQR  A 544 (-4.1A)
 1.13A 2rctA-5g5zA:
undetectable		 2rctA-5g5zA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 GLN A 302
THR A 185
TRP A 203
 None
 1.17A 2rctA-5gn5A:
undetectable		 2rctA-5gn5A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		3 GLN A 131
THR A 323
TRP A  95
 None
HEM  A 801 (-3.4A)
None
 1.15A 2rctA-5kqiA:
undetectable		 2rctA-5kqiA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		3 GLN A 195
THR A 244
TRP A 626
 None
 1.08A 2rctA-5m60A:
undetectable		 2rctA-5m60A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 3 GLN A 330
THR A 296
TRP A 211
 None
 1.16A 2rctA-5obuA:
undetectable		 2rctA-5obuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 3 GLN A 570
THR A 468
TRP A 507
 None
 1.18A 2rctA-5ohsA:
undetectable		 2rctA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		3 GLN A  34
THR A 479
TRP A 523
 None
 0.79A 2rctA-5ubkA:
undetectable		 2rctA-5ubkA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		3 GLN A 483
THR A 189
TRP A 162
 None
None
83M  A 801 (-4.4A)
 1.05A 2rctA-5ubkA:
undetectable		 2rctA-5ubkA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa) 		no annotation 3 GLN X 251
THR X 221
TRP X  84
 None
 1.05A 2rctA-5vtmX:
undetectable		 2rctA-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 3 GLN B 750
THR B 673
TRP B 655
 None
 1.15A 2rctA-5wfcB:
undetectable		 2rctA-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		3 GLN A 605
THR A  89
TRP A 645
 None
None
MB5  A 718 (-4.3A)
 0.94A 2rctA-5wgxA:
undetectable		 2rctA-5wgxA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aliivibrio
fischeri) 		no annotation 3 GLN A 345
THR A 228
TRP A 351
 None
 0.71A 2rctA-5xi0A:
undetectable		 2rctA-5xi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1) 		no annotation 3 GLN A  69
THR A  56
TRP A 131
 None
 0.95A 2rctA-5xzuA:
undetectable		 2rctA-5xzuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y16 DUAL SPECIFICITY
PHOSPHATASE 28

(Homo sapiens) 		no annotation 3 GLN A 158
THR A 115
TRP A 147
 None
 0.95A 2rctA-5y16A:
undetectable		 2rctA-5y16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhj CYTOCHROME P450

(Exiguobacterium
sp. AT1b) 		no annotation 3 GLN A 371
THR A 241
TRP A 146
 None
HEM  A 501 (-3.4A)
None
 0.48A 2rctA-5yhjA:
undetectable		 2rctA-5yhjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 3 GLN A 510
THR A 571
TRP A 480
 None
 1.02A 2rctA-5z06A:
undetectable		 2rctA-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cud SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 3

(Homo sapiens) 		no annotation 3 GLN A 481
THR A 419
TRP A 517
 None
 1.08A 2rctA-6cudA:
undetectable		 2rctA-6cudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 3 GLN A 181
THR A 209
TRP A 237
 None
 1.09A 2rctA-6eotA:
undetectable		 2rctA-6eotA:
undetectable