SIMILAR PATTERNS OF AMINO ACIDS FOR 2R3A_A_SAMA304_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 6 | ARG A 159GLY A 160TRP A 161HIS A 242TYR A 283CYH A 308 | NoneSAH A 319 ( 4.6A)SAH A 319 (-4.8A)SAH A 319 (-4.3A)SAH A 319 (-4.7A) ZN A 4 (-2.2A) | 1.33A | 2r3aA-1pegA:27.1 | 2r3aA-1pegA:35.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 9 | ARG A 159GLY A 160TRP A 161TYR A 204HIS A 242TYR A 283CYH A 306CYH A 308LEU A 317 | NoneSAH A 319 ( 4.6A)SAH A 319 (-4.8A)SAH A 319 (-4.0A)SAH A 319 (-4.3A)SAH A 319 (-4.7A) ZN A 4 ( 2.3A) ZN A 4 (-2.2A)SAH A 319 (-3.9A) | 0.58A | 2r3aA-1pegA:27.1 | 2r3aA-1pegA:35.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | ARG A 150GLY A 149HIS A 220CYH A 289LEU A 298 | NoneNoneSAM A 304 (-4.9A) ZN A 300 ( 2.3A)SAM A 304 (-4.7A) | 1.25A | 2r3aA-2r3aA:47.2 | 2r3aA-2r3aA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 12 | ARG A 150GLY A 151TRP A 152LYS A 189THR A 192TYR A 193HIS A 220TYR A 261CYH A 287LYS A 288CYH A 289LEU A 298 | NoneSAM A 304 (-3.5A)NoneSAM A 304 (-3.9A)SAM A 304 (-3.6A)SAM A 304 (-4.2A)SAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A)None ZN A 300 ( 2.3A)SAM A 304 (-4.7A) | 0.04A | 2r3aA-2r3aA:47.2 | 2r3aA-2r3aA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5z | HISTONE-LYSINEN-METHYLTRANSFERASEHRX (Homo sapiens) |
PF00856(SET) | 6 | GLY A3840HIS A3907TYR A3944CYH A3957CYH A3959LEU A3968 | SAH A4971 ( 3.7A)SAH A4971 (-4.7A)SAH A4971 (-4.9A) ZN A4970 ( 2.3A) ZN A4970 (-2.3A)SAH A4971 ( 4.9A) | 0.44A | 2r3aA-2w5zA:12.9 | 2r3aA-2w5zA:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5z | HISTONE-LYSINEN-METHYLTRANSFERASEHRX (Homo sapiens) |
PF00856(SET) | 5 | GLY A3840TYR A3883HIS A3907CYH A3957CYH A3959 | SAH A4971 ( 3.7A)NoneSAH A4971 (-4.7A) ZN A4970 ( 2.3A) ZN A4970 (-2.3A) | 0.70A | 2r3aA-2w5zA:12.9 | 2r3aA-2w5zA:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bn1 | PEROSAMINESYNTHETASE (Caulobactervibrioides) |
PF01041(DegT_DnrJ_EryC1) | 5 | ARG A 271GLY A 269LYS A 274TYR A 288LEU A 292 | None | 1.22A | 2r3aA-3bn1A:undetectable | 2r3aA-3bn1A:20.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3bo5 | HISTONE-LYSINEN-METHYLTRANSFERASESETMAR (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A 136TRP A 137HIS A 210TYR A 248CYH A 275 | SAH A 305 (-3.8A)NoneNoneSAH A 305 (-4.9A) ZN A 304 ( 2.3A) | 1.34A | 2r3aA-3bo5A:26.2 | 2r3aA-3bo5A:30.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3bo5 | HISTONE-LYSINEN-METHYLTRANSFERASESETMAR (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 8 | GLY A 136TRP A 137TYR A 178HIS A 210TYR A 248CYH A 273CYH A 275LEU A 284 | SAH A 305 (-3.8A)NoneSAH A 305 (-4.0A)NoneSAH A 305 (-4.9A) ZN A 304 ( 2.3A) ZN A 304 ( 2.3A)SAH A 305 (-4.5A) | 0.49A | 2r3aA-3bo5A:26.2 | 2r3aA-3bo5A:30.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9j | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 1 (Rattusnorvegicus) |
PF00520(Ion_trans) | 5 | GLY A 242THR A 267TYR A 204CYH A 231LEU A 208 | None | 1.28A | 2r3aA-3j9jA:undetectable | 2r3aA-3j9jA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ky9 | PROTO-ONCOGENE VAV (Homo sapiens) |
PF00130(C1_1)PF00169(PH)PF00621(RhoGEF)PF11971(CAMSAP_CH) | 5 | TYR A 541HIS A 554CYH A 529LYS A 530LEU A 536 | None ZN A 901 (-3.3A) ZN A 901 (-2.5A)NoneNone | 1.41A | 2r3aA-3ky9A:undetectable | 2r3aA-3ky9A:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | GLY A 16HIS A 206TYR A 252CYH A 274CYH A 276 | NoneNoneSFG A 491 (-4.8A) ZN A 497 (-2.2A) ZN A 497 (-2.5A) | 1.02A | 2r3aA-3n71A:5.4 | 2r3aA-3n71A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | HIS A 206TYR A 252CYH A 274CYH A 276LEU A 266 | NoneSFG A 491 (-4.8A) ZN A 497 (-2.2A) ZN A 497 (-2.5A)None | 1.24A | 2r3aA-3n71A:5.4 | 2r3aA-3n71A:21.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 9 | ARG A 101GLY A 102TRP A 103TYR A 146HIS A 170TYR A 207CYH A 219CYH A 221LEU A 230 | SO4 A 235 ( 4.0A)SAM A 237 ( 3.7A)NoneSAM A 237 (-4.1A)SAM A 237 (-4.7A)None ZN A 232 ( 2.3A) ZN A 232 (-2.3A)SAM A 237 (-4.8A) | 0.72A | 2r3aA-3ooiA:19.6 | 2r3aA-3ooiA:30.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 6 | ARG A 101TYR A 120HIS A 170TYR A 207CYH A 221LEU A 230 | SO4 A 235 ( 4.0A)NoneSAM A 237 (-4.7A)None ZN A 232 (-2.3A)SAM A 237 (-4.8A) | 1.46A | 2r3aA-3ooiA:19.6 | 2r3aA-3ooiA:30.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 7 | TYR A 146HIS A 170TYR A 207CYH A 219LYS A 220CYH A 221LEU A 230 | SAM A 237 (-4.1A)SAM A 237 (-4.7A)None ZN A 232 ( 2.3A)None ZN A 232 (-2.3A)SAM A 237 (-4.8A) | 0.96A | 2r3aA-3ooiA:19.6 | 2r3aA-3ooiA:30.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 7 | GLY A2151TRP A2152TYR A2194HIS A2218TYR A2255CYH A2268CYH A2270 | SAM A 7 (-3.4A)NoneSAM A 7 (-3.4A)NoneNone ZN A 1 ( 2.5A) ZN A 1 (-2.7A) | 0.59A | 2r3aA-3opeA:18.6 | 2r3aA-3opeA:28.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 6 | TYR A2194HIS A2218TYR A2255CYH A2268LYS A2269CYH A2270 | SAM A 7 (-3.4A)NoneNone ZN A 1 ( 2.5A)None ZN A 1 (-2.7A) | 0.94A | 2r3aA-3opeA:18.6 | 2r3aA-3opeA:28.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmu | HISTONE-LYSINEN-METHYLTRANSFERASESETD2 (Homo sapiens) |
PF00856(SET) | 7 | GLY A1561TRP A1562TYR A1605HIS A1629CYH A1678CYH A1680LEU A1689 | 0UM A1804 (-3.5A)None0UM A1804 (-4.2A)None ZN A1803 ( 2.2A) ZN A1803 (-2.2A)0UM A1804 (-4.8A) | 0.55A | 2r3aA-4fmuA:18.5 | 2r3aA-4fmuA:29.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gtv | GERANYLGERANYLTRANSFERASE TYPE-2SUBUNIT ALPHA (Rattusnorvegicus) |
PF01239(PPTA) | 5 | THR A 299TYR A 296CYH A 273CYH A 260LEU A 274 | None | 1.36A | 2r3aA-4gtvA:undetectable | 2r3aA-4gtvA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qeo | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-9 SPECIFICSUVH4 (Arabidopsisthaliana) |
PF00856(SET)PF02182(SAD_SRA)PF05033(Pre-SET) | 7 | GLY A 457TRP A 458HIS A 552TYR A 593CYH A 612CYH A 614LEU A 623 | SAH A 801 (-3.6A)SAH A 801 (-4.9A)NoneNone ZN A 805 ( 2.4A) ZN A 805 ( 2.4A)None | 0.37A | 2r3aA-4qeoA:27.6 | 2r3aA-4qeoA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qeo | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-9 SPECIFICSUVH4 (Arabidopsisthaliana) |
PF00856(SET)PF02182(SAD_SRA)PF05033(Pre-SET) | 7 | GLY A 457TYR A 493HIS A 552TYR A 593CYH A 612CYH A 614LEU A 623 | SAH A 801 (-3.6A)SAH A 801 (-4.0A)NoneNone ZN A 805 ( 2.4A) ZN A 805 ( 2.4A)None | 0.75A | 2r3aA-4qeoA:27.6 | 2r3aA-4qeoA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4p | HISTONE-LYSINEN-METHYLTRANSFERASE2D (Homo sapiens) |
PF00856(SET) | 6 | GLY A5408TYR A5451HIS A5475TYR A5512CYH A5525CYH A5527 | SAH A5602 (-3.6A)SAH A5602 (-4.5A)NoneNone ZN A5601 ( 2.2A) ZN A5601 ( 2.2A) | 0.74A | 2r3aA-4z4pA:13.8 | 2r3aA-4z4pA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f59 | HISTONE-LYSINEN-METHYLTRANSFERASE2C (Homo sapiens) |
PF00856(SET) | 5 | GLY A4782HIS A4849TYR A4886CYH A4899CYH A4901 | SAH A5002 (-3.5A)SAH A5002 (-4.6A)None ZN A5001 ( 2.0A) ZN A5001 (-2.3A) | 0.33A | 2r3aA-5f59A:13.6 | 2r3aA-5f59A:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f59 | HISTONE-LYSINEN-METHYLTRANSFERASE2C (Homo sapiens) |
PF00856(SET) | 5 | GLY A4782TYR A4825HIS A4849CYH A4899CYH A4901 | SAH A5002 (-3.5A)SAH A5002 (-4.5A)SAH A5002 (-4.6A) ZN A5001 ( 2.0A) ZN A5001 (-2.3A) | 0.80A | 2r3aA-5f59A:13.6 | 2r3aA-5f59A:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f6l | HISTONE-LYSINEN-METHYLTRANSFERASE2A (Homo sapiens) |
PF00856(SET) | 7 | GLY A3840TYR A3883HIS A3907TYR A3944CYH A3957CYH A3959LEU A3968 | SAH A4001 (-3.4A)NoneSAH A4001 (-4.9A)SAH A4001 (-4.9A) ZN A4002 ( 2.3A) ZN A4002 (-2.3A)None | 0.55A | 2r3aA-5f6lA:14.0 | 2r3aA-5f6lA:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kjm | N-LYSINEMETHYLTRANSFERASESMYD2 (Homo sapiens) |
PF00856(SET)PF01753(zf-MYND) | 5 | GLY A 16HIS A 207TYR A 240CYH A 262CYH A 264 | NoneNone6TM A 502 ( 3.6A) ZN A 505 (-2.3A) ZN A 505 (-2.4A) | 1.09A | 2r3aA-5kjmA:5.9 | 2r3aA-5kjmA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kjm | N-LYSINEMETHYLTRANSFERASESMYD2 (Homo sapiens) |
PF00856(SET)PF01753(zf-MYND) | 5 | HIS A 207TYR A 240CYH A 262CYH A 264LEU A 254 | None6TM A 502 ( 3.6A) ZN A 505 (-2.3A) ZN A 505 (-2.4A)None | 1.29A | 2r3aA-5kjmA:5.9 | 2r3aA-5kjmA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsu | HISTONE-LYSINEN-METHYLTRANSFERASENSD2 (Homo sapiens) |
PF00856(SET) | 9 | ARG A1073GLY A1074TRP A1075TYR A1118HIS A1142TYR A1179CYH A1191CYH A1193LEU A1202 | NoneSAM A1304 ( 3.2A)NoneSAM A1304 (-3.8A)SAM A1304 (-4.6A)SAM A1304 (-4.1A) ZN A1301 ( 2.3A) ZN A1301 (-2.3A)SAM A1304 ( 4.7A) | 0.49A | 2r3aA-5lsuA:20.4 | 2r3aA-5lsuA:28.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsu | HISTONE-LYSINEN-METHYLTRANSFERASENSD2 (Homo sapiens) |
PF00856(SET) | 6 | GLY A1074TRP A1075TYR A1118HIS A1142TYR A1179CYH A1193 | SAM A1304 ( 3.2A)NoneSAM A1304 (-3.8A)SAM A1304 (-4.6A)SAM A1304 (-4.1A) ZN A1301 (-2.3A) | 1.42A | 2r3aA-5lsuA:20.4 | 2r3aA-5lsuA:28.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1049TRP A1050HIS A1113TYR A1154CYH A1168 | SAM A1505 ( 3.9A)NoneSAM A1505 (-4.7A)SAM A1505 (-4.9A) ZN A1504 (-2.2A) | 1.42A | 2r3aA-5tuyA:28.1 | 2r3aA-5tuyA:35.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 7 | GLY A1049TRP A1050TYR A1085HIS A1113TYR A1154CYH A1168CYH A1170 | SAM A1505 ( 3.9A)NoneSAM A1505 (-4.0A)SAM A1505 (-4.7A)SAM A1505 (-4.9A) ZN A1504 (-2.2A) ZN A1504 (-2.2A) | 0.41A | 2r3aA-5tuyA:28.1 | 2r3aA-5tuyA:35.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vsd | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 7 | GLY A1137TRP A1138TYR A1173HIS A1201TYR A1242CYH A1256CYH A1258 | SAM A3001 (-3.6A)NoneSAM A3001 (-4.0A)SAM A3001 (-4.6A)SAM A3001 (-4.8A) ZN A3005 ( 2.4A) ZN A3005 (-2.3A) | 0.41A | 2r3aA-5vsdA:28.2 | 2r3aA-5vsdA:35.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxg | - (-) |
no annotation | 5 | GLY A 46THR A 39HIS A 83CYH A 65CYH A 62 | NoneNone ZN A 505 (-3.3A) ZN A 505 (-2.3A) ZN A 505 (-2.3A) | 1.40A | 2r3aA-5xxgA:5.7 | 2r3aA-5xxgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cen | HISTONE-LYSINEN-METHYLTRANSFERASENSD3 (Homo sapiens) |
no annotation | 9 | ARG A1155GLY A1156TRP A1157TYR A1200HIS A1224TYR A1261CYH A1273CYH A1275LEU A1284 | NoneSAM A1301 (-3.6A)NoneSAM A1301 (-3.9A)NoneSAM A1301 (-4.9A) ZN A1304 ( 2.3A) ZN A1304 (-2.3A)SAM A1301 (-4.6A) | 0.62A | 2r3aA-6cenA:20.2 | 2r3aA-6cenA:29.04 |