SIMILAR PATTERNS OF AMINO ACIDS FOR 2QXS_A_RALA600_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT
[NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU B 121
ASP B 125
LEU B 206
HIS A  45
 None
 1.22A 2qxsA-1e3dB:
0.3		 2qxsA-1e3dB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ASP A 409
MET A 264
LEU A 225
HIS A  90
 None
None
None
ZN  A1102 ( 3.3A)
 1.02A 2qxsA-1hwwA:
0.0		 2qxsA-1hwwA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT
II

(Salmonella
enterica) 		PF00117
(GATase) 		4 LEU B 143
ASP B 159
LEU B  70
HIS B  86
 None
 1.24A 2qxsA-1i1qB:
0.0		 2qxsA-1i1qB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens) 		PF00117
(GATase) 		4 LEU B 146
ASP B 162
LEU B  72
HIS B  88
 None
 1.14A 2qxsA-1i7qB:
0.0		 2qxsA-1i7qB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		4 LEU A 197
MET A   9
LEU A  60
HIS A 210
 None
None
None
FE2  A 500 ( 3.5A)
 1.06A 2qxsA-1lkdA:
undetectable		 2qxsA-1lkdA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.19A 2qxsA-1lpfA:
undetectable		 2qxsA-1lpfA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrv LEUCINE-RICH REPEAT
VARIANT

(Azotobacter
vinelandii) 		PF01816
(LRV)
PF05484
(LRV_FeS) 		4 LEU A 212
ASP A 207
LEU A 223
HIS A 217
 None
 1.15A 2qxsA-1lrvA:
0.0		 2qxsA-1lrvA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ASP A 351
MET A 388
LEU A 428
HIS A 524
 None
None
None
EST  A   1 (-3.8A)
 0.79A 2qxsA-1pcgA:
32.5		 2qxsA-1pcgA:
98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
MET A 388
LEU A 428
HIS A 524
 EST  A   1 (-4.4A)
None
None
EST  A   1 (-3.8A)
 0.46A 2qxsA-1pcgA:
32.5		 2qxsA-1pcgA:
98.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8i TRAC

(Escherichia
coli) 		PF07996
(T4SS) 		4 LEU A  41
ASP A 172
MET A 160
LEU A  48
 None
 1.22A 2qxsA-1r8iA:
1.7		 2qxsA-1r8iA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		4 LEU A  47
ASP A 101
LEU A   9
HIS A 120
 None
None
None
CU  A 155 (-3.0A)
 1.05A 2qxsA-1srdA:
undetectable		 2qxsA-1srdA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 LEU B 113
ASP B 117
MET B  45
HIS B  60
 None
 0.82A 2qxsA-1sxjB:
undetectable		 2qxsA-1sxjB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqy HYPOTHETICAL PROTEIN
AGR_PAT_315

(Agrobacterium
fabrum) 		PF07978
(NIPSNAP) 		4 LEU A  83
MET A  15
LEU A  19
HIS A  53
 None
 1.15A 2qxsA-1vqyA:
undetectable		 2qxsA-1vqyA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE

(Pyrobaculum
aerophilum) 		PF09171
(AGOG) 		4 LEU A 126
ASP A 121
MET A  52
LEU A  56
 None
 1.26A 2qxsA-1xqpA:
undetectable		 2qxsA-1xqpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C) 		4 LEU A 285
ASP A 283
MET A 312
LEU A 321
 None
 1.28A 2qxsA-1zvuA:
undetectable		 2qxsA-1zvuA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1

(Homo sapiens) 		PF01112
(Asparaginase_2) 		4 LEU A 310
ASP A 314
MET A 323
LEU A 302
 None
 1.25A 2qxsA-2a8iA:
undetectable		 2qxsA-2a8iA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4a BH3024

(Bacillus
halodurans) 		PF00072
(Response_reg) 		4 LEU A 100
ASP A  56
LEU A  23
HIS A 116
 None
 1.01A 2qxsA-2b4aA:
undetectable		 2qxsA-2b4aA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crf RAN BINDING PROTEIN
3

(Homo sapiens) 		PF00638
(Ran_BP1) 		4 LEU A  67
ASP A  64
LEU A  56
HIS A 134
 None
 1.00A 2qxsA-2crfA:
undetectable		 2qxsA-2crfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		4 LEU A  70
ASP A 165
LEU A 102
HIS A  49
 None
 1.20A 2qxsA-2cybA:
undetectable		 2qxsA-2cybA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 439
ASP A 407
MET A 432
LEU A 428
 None
 1.24A 2qxsA-2eq9A:
undetectable		 2qxsA-2eq9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		4 LEU A 123
ASP A 191
MET A 174
LEU A 176
 None
 1.21A 2qxsA-2f8lA:
undetectable		 2qxsA-2f8lA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		4 LEU A  63
ASP A 100
MET A  50
LEU A  75
 None
 1.19A 2qxsA-2iuyA:
undetectable		 2qxsA-2iuyA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		4 LEU A 388
ASP A 391
LEU A 404
HIS A 314
 None
 1.07A 2qxsA-2jg7A:
undetectable		 2qxsA-2jg7A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		4 LEU A 517
MET A 457
LEU A 568
HIS A 554
 None
 1.27A 2qxsA-2jh9A:
undetectable		 2qxsA-2jh9A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb2 BLRP1

(Klebsiella
pneumoniae) 		PF04940
(BLUF) 		4 LEU A  43
ASP A  99
LEU A  80
HIS A  74
 FMN  A 149 ( 4.3A)
None
None
FMN  A 149 ( 3.6A)
 1.13A 2qxsA-2kb2A:
undetectable		 2qxsA-2kb2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		4 LEU A 479
ASP A 485
LEU A 354
HIS A 474
 None
 0.97A 2qxsA-2nrrA:
undetectable		 2qxsA-2nrrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 LEU A 203
ASP A 169
LEU A 188
HIS A 174
 None
 1.04A 2qxsA-2o4cA:
undetectable		 2qxsA-2o4cA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 346
MET A 388
LEU A 428
HIS A 524
 EST  A 596 (-4.4A)
None
None
EST  A 596 (-4.2A)
 0.43A 2qxsA-2ocfA:
31.4		 2qxsA-2ocfA:
99.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		4 LEU A  40
ASP A 178
MET A  70
LEU A  79
 None
 1.23A 2qxsA-2ozeA:
undetectable		 2qxsA-2ozeA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbx HEMAGGLUTININ/PROTEA
SE REGULATORY
PROTEIN

(Vibrio cholerae) 		PF00440
(TetR_N) 		4 LEU A  80
MET A 101
LEU A 112
HIS A 168
 None
 1.24A 2qxsA-2pbxA:
undetectable		 2qxsA-2pbxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 LEU A 171
ASP A 174
MET A 239
LEU A 186
 None
 1.27A 2qxsA-2pwhA:
undetectable		 2qxsA-2pwhA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 LEU A 178
ASP A 174
MET A 239
LEU A 186
 None
 1.18A 2qxsA-2pwhA:
undetectable		 2qxsA-2pwhA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind)
PF09228
(Prok-TraM) 		4 LEU A 161
ASP C  72
MET A 128
LEU A 154
 None
 1.10A 2qxsA-2q0oA:
undetectable		 2qxsA-2q0oA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 LEU A  51
ASP A  82
LEU A 104
HIS A 114
 None
 1.28A 2qxsA-2qedA:
undetectable		 2qxsA-2qedA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		4 LEU A 372
ASP A 365
MET A 333
LEU A 337
 None
 1.31A 2qxsA-2qneA:
undetectable		 2qxsA-2qneA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU A 233
ASP A 226
LEU A 258
HIS A 201
 None
 1.20A 2qxsA-2rfaA:
undetectable		 2qxsA-2rfaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 490
ASP A 688
MET A 193
LEU A 189
 None
 1.22A 2qxsA-2xf2A:
undetectable		 2qxsA-2xf2A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 LEU A  48
ASP A  31
LEU A  67
HIS A  22
 None
None
HEM  A 350 ( 4.8A)
None
 0.81A 2qxsA-2yp1A:
undetectable		 2qxsA-2yp1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 179
ASP A 169
LEU A 227
HIS A 206
 None
 1.31A 2qxsA-2z81A:
undetectable		 2qxsA-2z81A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 LEU A 157
ASP A 182
MET A  93
HIS A  64
 HTL  A 827 (-3.9A)
MG  A 826 ( 2.8A)
None
HTL  A 827 (-4.3A)
 1.23A 2qxsA-3ahiA:
undetectable		 2qxsA-3ahiA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 LEU A 157
ASP A 182
MET A  93
HIS A  64
 TPP  A 900 (-4.0A)
CA  A 901 ( 3.0A)
None
None
 1.24A 2qxsA-3ai7A:
undetectable		 2qxsA-3ai7A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq8 SENSOR PROTEIN PHOQ

(Escherichia
coli) 		PF08918
(PhoQ_Sensor) 		4 LEU A 132
ASP A 125
MET A 106
LEU A  87
 None
 1.19A 2qxsA-3bq8A:
undetectable		 2qxsA-3bq8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		4 ASP A 152
MET A 213
LEU A 230
HIS A 223
 None
 1.14A 2qxsA-3cijA:
undetectable		 2qxsA-3cijA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwv DNA GYRASE, B
SUBUNIT, TRUNCATED

(Myxococcus
xanthus) 		PF00204
(DNA_gyraseB) 		4 LEU A 299
ASP A 247
LEU A 279
HIS A 346
 None
 1.09A 2qxsA-3cwvA:
undetectable		 2qxsA-3cwvA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		4 LEU A 241
ASP A 351
MET A 302
LEU A 273
 None
 1.19A 2qxsA-3d3lA:
undetectable		 2qxsA-3d3lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF08477
(Roc)
PF16095
(COR) 		4 LEU A 613
ASP A 503
LEU A 468
HIS A 596
 None
 1.27A 2qxsA-3dpuA:
undetectable		 2qxsA-3dpuA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		4 LEU A 205
ASP A 226
LEU A 198
HIS A 263
 None
 1.08A 2qxsA-3gzsA:
undetectable		 2qxsA-3gzsA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw PSEUDOURIDINE
SYNTHASE CBF5

(Pyrococcus
furiosus) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 LEU A 289
MET A 293
LEU A 299
HIS A 252
 None
 1.27A 2qxsA-3hjwA:
undetectable		 2qxsA-3hjwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 LEU A   9
ASP A  14
MET A  46
HIS A  61
 None
 1.19A 2qxsA-3kd8A:
undetectable		 2qxsA-3kd8A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kin KINESIN HEAVY CHAIN

(Rattus
norvegicus) 		PF00225
(Kinesin) 		4 LEU A 210
ASP A 145
MET B 284
LEU B 288
 None
 1.10A 2qxsA-3kinA:
undetectable		 2qxsA-3kinA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.29A 2qxsA-3ladA:
undetectable		 2qxsA-3ladA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmz PUTATIVE SUGAR
ISOMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 LEU A  58
ASP A  77
MET A  48
LEU A  65
 None
 1.25A 2qxsA-3lmzA:
undetectable		 2qxsA-3lmzA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU B1111
ASP B1115
LEU B1195
HIS A  44
 None
 1.14A 2qxsA-3myrB:
undetectable		 2qxsA-3myrB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 4 ASP B 264
MET B 284
LEU B 271
HIS B 392
 None
 1.26A 2qxsA-3ozvB:
undetectable		 2qxsA-3ozvB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 407
MET A 414
LEU A 457
HIS A 364
 None
EDO  A 921 (-3.6A)
None
None
 1.32A 2qxsA-3p5pA:
2.3		 2qxsA-3p5pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP) 		PF00945
(Rhabdo_ncap) 		4 ASP A  23
MET A 261
LEU A 228
HIS A 298
 None
 1.12A 2qxsA-3pmkA:
undetectable		 2qxsA-3pmkA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		4 LEU A 125
ASP A 131
LEU A  20
HIS A  97
 None
 1.13A 2qxsA-3rysA:
undetectable		 2qxsA-3rysA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rzv STAM-BINDING PROTEIN

(Homo sapiens) 		PF01398
(JAB) 		4 LEU A 263
ASP A 415
LEU A 331
HIS A 298
 None
 1.28A 2qxsA-3rzvA:
undetectable		 2qxsA-3rzvA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 LEU B 603
ASP B 625
LEU B 524
HIS B 598
 None
 1.29A 2qxsA-3tixB:
undetectable		 2qxsA-3tixB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		4 LEU A 867
ASP A 862
LEU A 840
HIS A 872
 None
 1.22A 2qxsA-3ux8A:
undetectable		 2qxsA-3ux8A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		4 LEU A  13
ASP A  10
MET A 285
LEU A 283
 None
 1.19A 2qxsA-3vcyA:
undetectable		 2qxsA-3vcyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6x MPR1 PROTEIN

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A  99
ASP A 102
LEU A 153
HIS A 144
 None
 1.28A 2qxsA-3w6xA:
undetectable		 2qxsA-3w6xA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		4 LEU A  49
ASP A  67
LEU A 183
HIS A  52
 None
 1.28A 2qxsA-3wibA:
undetectable		 2qxsA-3wibA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		4 LEU A 200
ASP A 316
MET A 204
LEU A 130
 None
 1.28A 2qxsA-4au2A:
undetectable		 2qxsA-4au2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7x PROBABLE
OXIDOREDUCTASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 LEU A 139
ASP A 141
MET A 292
LEU A 301
 None
 1.31A 2qxsA-4b7xA:
undetectable		 2qxsA-4b7xA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		4 LEU A 139
MET A 131
LEU A  96
HIS A  32
 None
 1.07A 2qxsA-4cs6A:
undetectable		 2qxsA-4cs6A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF00563
(EAL) 		4 LEU A 181
ASP A 188
MET A 224
LEU A  31
 None
 1.27A 2qxsA-4f48A:
undetectable		 2qxsA-4f48A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 LEU  A 232 ( 0.5A)
ASP  A 235 ( 0.5A)
LEU  A 138 ( 0.5A)
HIS  A 257 ( 1.0A)
 1.23A 2qxsA-4flxA:
undetectable		 2qxsA-4flxA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxb PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 LEU A 265
ASP A 267
MET A 257
LEU A 370
 None
 0.98A 2qxsA-4fxbA:
1.1		 2qxsA-4fxbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 281
ASP A 415
MET A 311
LEU A 274
 None
 1.15A 2qxsA-4g1pA:
undetectable		 2qxsA-4g1pA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		4 LEU A  47
ASP A  41
LEU A  66
HIS A 188
 OXD  A 407 (-4.5A)
None
None
CA  A 401 (-3.5A)
 1.25A 2qxsA-4infA:
undetectable		 2qxsA-4infA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI

(Caulobacter
vibrioides) 		PF06230
(DUF1009) 		4 LEU A 191
ASP A 196
LEU A 269
HIS A 235
 None
 0.73A 2qxsA-4j6eA:
undetectable		 2qxsA-4j6eA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		4 LEU A 207
ASP A 210
MET A 266
LEU A 270
 None
 1.27A 2qxsA-4lx4A:
undetectable		 2qxsA-4lx4A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		4 LEU A 798
ASP A 791
LEU A 782
HIS A 889
 None
 1.25A 2qxsA-4n78A:
undetectable		 2qxsA-4n78A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou4 ALPHA/BETA HYDROLASE
FOLD-3 DOMAIN
PROTEIN

(Pseudomonas sp.
ECU1011) 		PF07859
(Abhydrolase_3) 		4 ASP A 256
MET A 304
LEU A 104
HIS A  97
 None
 1.30A 2qxsA-4ou4A:
undetectable		 2qxsA-4ou4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0e MAF-LIKE PROTEIN
YHDE

(Escherichia
coli) 		PF02545
(Maf) 		4 LEU A  93
ASP A 131
LEU A 144
HIS A  88
 None
 0.78A 2qxsA-4p0eA:
undetectable		 2qxsA-4p0eA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 LEU A 741
ASP A 743
MET A 840
LEU A 756
 None
 1.25A 2qxsA-4q8hA:
undetectable		 2qxsA-4q8hA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		4 LEU A 155
ASP A  21
LEU A  70
HIS A  11
 None
 1.28A 2qxsA-4qr8A:
undetectable		 2qxsA-4qr8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF01547
(SBP_bac_1) 		4 LEU A 231
ASP A 176
LEU A 413
HIS A 399
 None
 1.17A 2qxsA-4rk2A:
undetectable		 2qxsA-4rk2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvp SUPEROXIDE DISMUTASE

(Sedum alfredii) 		PF00080
(Sod_Cu) 		4 LEU A  59
ASP A 113
LEU A  21
HIS A 132
 None
 1.05A 2qxsA-4rvpA:
undetectable		 2qxsA-4rvpA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT
PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU L 131
ASP L 135
LEU L 216
HIS S  45
 None
 1.12A 2qxsA-4u9iL:
undetectable		 2qxsA-4u9iL:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG

(Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind) 		4 LEU A 136
ASP A 161
MET A 175
LEU A 107
 None
 1.09A 2qxsA-4yryA:
undetectable		 2qxsA-4yryA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG

(Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind) 		4 LEU A 136
ASP A 162
MET A 175
LEU A 107
 None
NAD  A 503 ( 3.7A)
None
None
 0.96A 2qxsA-4yryA:
undetectable		 2qxsA-4yryA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 217
ASP A 212
LEU A 226
HIS A 222
 None
 1.06A 2qxsA-4z0cA:
undetectable		 2qxsA-4z0cA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 LEU A 237
ASP A 240
LEU A 312
HIS A 208
 None
 1.18A 2qxsA-5ddsA:
undetectable		 2qxsA-5ddsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elr KH
DOMAIN-CONTAINING,
RNA-BINDING, SIGNAL
TRANSDUCTION-ASSOCIA
TED PROTEIN 3

(Homo sapiens) 		PF00013
(KH_1) 		4 LEU C 127
ASP C 125
MET C  95
LEU C  84
 None
None
None
A  B   7 ( 4.9A)
 1.30A 2qxsA-5elrC:
undetectable		 2qxsA-5elrC:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 LEU A 320
MET A 312
LEU A  51
HIS A  39
 None
 1.31A 2qxsA-5g2vA:
undetectable		 2qxsA-5g2vA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmk PRE-MRNA-SPLICING
FACTOR CWC22

(Saccharomyces
cerevisiae) 		PF02847
(MA3) 		4 LEU Z  94
MET Z  99
LEU Z 121
HIS Z 225
 None
 1.15A 2qxsA-5gmkZ:
undetectable		 2qxsA-5gmkZ:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 None
 1.25A 2qxsA-5h12A:
1.9		 2qxsA-5h12A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 276
ASP A 282
MET A  58
LEU A 258
 None
 0.91A 2qxsA-5iy9A:
undetectable		 2qxsA-5iy9A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnq PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

([Clostridium]
bolteae) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 LEU A 177
ASP A 175
MET A 286
LEU A 295
 None
TUM  A 401 (-3.6A)
None
None
 1.24A 2qxsA-5jnqA:
undetectable		 2qxsA-5jnqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU B 302
ASP A  38
LEU B 291
HIS B 307
 None
 1.17A 2qxsA-5l3sB:
undetectable		 2qxsA-5l3sB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin)
no annotation 		4 LEU B 942
ASP A  77
MET B 907
LEU B 893
 None
 1.01A 2qxsA-5lxvB:
undetectable		 2qxsA-5lxvB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m04 GTPASE OBGE/CGTA

(Escherichia
coli) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 LEU A 159
ASP A   5
MET A   1
LEU A 227
 None
 1.27A 2qxsA-5m04A:
undetectable		 2qxsA-5m04A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrv CARBOXYPEPTIDASE O

(Homo sapiens) 		no annotation 4 LEU A 223
ASP A 276
MET A 215
LEU A 291
 None
 1.25A 2qxsA-5mrvA:
undetectable		 2qxsA-5mrvA:
11.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 298
MET A 340
LEU A 380
HIS A 475
 EST  A 601 (-4.1A)
EST  A 601 ( 4.8A)
None
EST  A 601 (-4.4A)
 0.46A 2qxsA-5toaA:
30.2		 2qxsA-5toaA:
57.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqk SULFURTRANSFERASE

(Mus musculus) 		PF00581
(Rhodanese) 		4 LEU A 128
ASP A 101
LEU A  20
HIS A  96
 None
 1.25A 2qxsA-5wqkA:
undetectable		 2qxsA-5wqkA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 LEU 2 322
ASP 2 324
MET 2 290
LEU 2 793
 None
 1.03A 2qxsA-5zvs2:
undetectable		 2qxsA-5zvs2:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 4 LEU A 134
ASP A 118
LEU A  73
HIS A 108
 None
 1.29A 2qxsA-6bk5A:
undetectable		 2qxsA-6bk5A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 4 LEU B 131
ASP B 193
LEU B 165
HIS B 115
 None
 1.13A 2qxsA-6emkB:
undetectable		 2qxsA-6emkB:
16.67