SIMILAR PATTERNS OF AMINO ACIDS FOR 2QQG_A_NCAA3721_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avg TRIABIN

(Meccus
pallidipennis) 		PF03973
(Triabin) 		3 PHE I  82
PHE I  96
PHE I  98
 None
 0.79A 2qqgA-1avgI:
undetectable		 2qqgA-1avgI:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 PHE A 415
PHE A 297
PHE A 319
 None
 0.74A 2qqgA-1bbuA:
undetectable		 2qqgA-1bbuA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE

(Salmonella
enterica) 		PF01739
(CheR)
PF03705
(CheR_N) 		3 PHE A 185
PHE A  96
PHE A  97
 None
 0.88A 2qqgA-1bc5A:
undetectable		 2qqgA-1bc5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		3 PHE A 161
PHE A 137
PHE A  83
 None
 0.84A 2qqgA-1c9wA:
undetectable		 2qqgA-1c9wA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 PHE A 512
PHE A 518
PHE A 529
 None
 0.79A 2qqgA-1cb8A:
undetectable		 2qqgA-1cb8A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm1 MYOGLOBIN

(Aplysia
limacina) 		PF00042
(Globin) 		3 PHE A  91
PHE A 105
PHE A 134
 HEM  A 148 (-4.6A)
HEM  A 148 (-4.4A)
None
 0.88A 2qqgA-1dm1A:
undetectable		 2qqgA-1dm1A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		3 PHE A 116
PHE A 126
PHE A 178
 None
 0.83A 2qqgA-1f5nA:
0.8		 2qqgA-1f5nA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 PHE A 166
PHE A 721
PHE A 723
 None
 0.79A 2qqgA-1fcpA:
undetectable		 2qqgA-1fcpA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 PHE A  44
PHE A  53
PHE A  85
 None
 0.85A 2qqgA-1hn0A:
undetectable		 2qqgA-1hn0A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 PHE A 400
PHE A 410
PHE A 407
 None
 0.86A 2qqgA-1ir6A:
6.6		 2qqgA-1ir6A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbg TRANSCRIPTION
ACTIVATOR OF
MULTIDRUG-EFFLUX
TRANSPORTER GENES
MTA

(Bacillus
subtilis) 		PF13411
(MerR_1) 		3 PHE A  74
PHE A  55
PHE A  60
 None
 0.83A 2qqgA-1jbgA:
undetectable		 2qqgA-1jbgA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		3 PHE A 371
PHE A 286
PHE A 408
 None
 0.81A 2qqgA-1ohfA:
undetectable		 2qqgA-1ohfA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 PHE A 122
PHE A  74
PHE A  29
 None
 0.83A 2qqgA-1pvdA:
7.3		 2qqgA-1pvdA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE III

(Paracoccus
denitrificans;
Paracoccus
denitrificans) 		PF00115
(COX1)
PF00510
(COX3) 		3 PHE A  19
PHE C  18
PHE C  19
 None
 0.80A 2qqgA-1qleA:
undetectable		 2qqgA-1qleA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tht THIOESTERASE

(Vibrio harveyi) 		PF02273
(Acyl_transf_2) 		3 PHE A  44
PHE A  84
PHE A 177
 None
 0.85A 2qqgA-1thtA:
3.1		 2qqgA-1thtA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 6

(Saccharomyces
cerevisiae) 		PF00443
(UCH) 		3 PHE A 229
PHE A 218
PHE A 214
 None
 0.79A 2qqgA-1vjvA:
undetectable		 2qqgA-1vjvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 PHE A 162
PHE A 568
PHE A 629
 None
 0.79A 2qqgA-1wkbA:
undetectable		 2qqgA-1wkbA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlo SUFE PROTEIN

(Thermus
thermophilus) 		PF02657
(SufE) 		3 PHE A  13
PHE A 110
PHE A 111
 None
 0.84A 2qqgA-1wloA:
undetectable		 2qqgA-1wloA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrj METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01035
(DNA_binding_1) 		3 PHE A  53
PHE A  11
PHE A  28
 None
 0.83A 2qqgA-1wrjA:
undetectable		 2qqgA-1wrjA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 PHE A 329
PHE A 380
PHE A 382
 None
 0.77A 2qqgA-1wydA:
undetectable		 2qqgA-1wydA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR

(Homo sapiens) 		PF01462
(LRRNT)
PF13306
(LRR_5) 		3 PHE C  53
PHE C  66
PHE C  69
 None
 0.73A 2qqgA-1xwdC:
undetectable		 2qqgA-1xwdC:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA

(Lactococcus
lactis) 		no annotation 3 PHE A  39
PHE A  72
PHE A  73
 None
 0.83A 2qqgA-1zs3A:
undetectable		 2qqgA-1zs3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0g WINDBEUTEL PROTEIN

(Drosophila
melanogaster) 		PF07749
(ERp29)
PF07912
(ERp29_N) 		3 PHE A1049
PHE A1109
PHE A1111
 None
 0.85A 2qqgA-2c0gA:
undetectable		 2qqgA-2c0gA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 PHE A1041
PHE A1030
PHE A1026
 None
 0.85A 2qqgA-2cfvA:
undetectable		 2qqgA-2cfvA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e71 TRANSCRIPTION
ELONGATION REGULATOR
1

(Homo sapiens) 		PF01846
(FF) 		3 PHE A 732
PHE A 750
PHE A 747
 None
 0.87A 2qqgA-2e71A:
undetectable		 2qqgA-2e71A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		3 PHE A 844
PHE A 832
PHE A 831
 None
 0.80A 2qqgA-2ec5A:
undetectable		 2qqgA-2ec5A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl1 RED FLUORESCENT
PROTEIN ZOANRFP

(Zoanthus sp.) 		PF01353
(GFP) 		3 PHE A 126
PHE A  97
PHE A  99
 None
 0.53A 2qqgA-2fl1A:
undetectable		 2qqgA-2fl1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF03054
(tRNA_Me_trans) 		3 PHE A 201
PHE A 210
PHE A 207
 None
 0.77A 2qqgA-2hmaA:
undetectable		 2qqgA-2hmaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogr FLUORESCENT PROTEIN
FP538

(Zoanthus sp.) 		PF01353
(GFP) 		3 PHE A 126
PHE A  97
PHE A  99
 None
 0.53A 2qqgA-2ogrA:
undetectable		 2qqgA-2ogrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506

(Zoanthus sp.) 		PF01353
(GFP) 		3 PHE A 126
PHE A  97
PHE A  99
 None
 0.48A 2qqgA-2pxsA:
undetectable		 2qqgA-2pxsA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r73 TRICHOSURIN

(Trichosurus
vulpecula) 		PF00061
(Lipocalin) 		3 PHE A 129
PHE A 112
PHE A 114
 None
 0.70A 2qqgA-2r73A:
undetectable		 2qqgA-2r73A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 PHE A  94
PHE A  25
PHE A  29
 None
 0.85A 2qqgA-2z1uA:
undetectable		 2qqgA-2z1uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 PHE X 203
PHE X 170
PHE X 174
 None
 0.86A 2qqgA-2zkmX:
undetectable		 2qqgA-2zkmX:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 PHE A 400
PHE A 410
PHE A 407
 None
 0.84A 2qqgA-2zxoA:
6.5		 2qqgA-2zxoA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		3 PHE A1274
PHE A1232
PHE A1246
 None
 0.84A 2qqgA-3av6A:
1.6		 2qqgA-3av6A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b98 PROSTAGLANDIN I2
SYNTHASE

(Danio rerio) 		PF00067
(p450) 		3 PHE A 106
PHE A 200
PHE A 197
 None
 0.88A 2qqgA-3b98A:
undetectable		 2qqgA-3b98A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		3 PHE A  79
PHE A  62
PHE A  66
 None
 0.85A 2qqgA-3bz5A:
undetectable		 2qqgA-3bz5A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		3 PHE A 116
PHE A 180
PHE A 183
 None
 0.75A 2qqgA-3c9bA:
undetectable		 2qqgA-3c9bA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do9 UPF0302 PROTEIN
BA_1542/GBAA1542/BAS
1430

(Bacillus
anthracis) 		PF08858
(IDEAL)
PF08864
(UPF0302) 		3 PHE A 103
PHE A  17
PHE A  13
 None
 0.88A 2qqgA-3do9A:
undetectable		 2qqgA-3do9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh6 MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALF

(Escherichia
coli) 		PF00528
(BPD_transp_1)
PF14785
(MalF_P2) 		3 PHE F 438
PHE F 281
PHE F 277
 None
 0.87A 2qqgA-3fh6F:
undetectable		 2qqgA-3fh6F:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		3 PHE A  61
PHE A 526
PHE A 418
 None
 0.69A 2qqgA-3fsnA:
undetectable		 2qqgA-3fsnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 PHE A 495
PHE A 559
PHE A 562
 None
 0.80A 2qqgA-3gwjA:
0.0		 2qqgA-3gwjA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Mus musculus) 		PF00155
(Aminotran_1_2) 		3 PHE A 291
PHE A 241
PHE A 239
 None
 0.87A 2qqgA-3hlmA:
0.6		 2qqgA-3hlmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		3 PHE A 920
PHE A 909
PHE A 905
 None
 0.87A 2qqgA-3i36A:
undetectable		 2qqgA-3i36A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX

(Aspergillus
fumigatus) 		PF02374
(ArsA_ATPase) 		3 PHE A 230
PHE A 168
PHE A 140
 None
 0.69A 2qqgA-3ibgA:
1.7		 2qqgA-3ibgA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifu NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05410
(Peptidase_C31) 		3 PHE A  94
PHE A  82
PHE A  17
 None
 0.81A 2qqgA-3ifuA:
undetectable		 2qqgA-3ifuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 PHE A 151
PHE A 288
PHE A 387
 None
 0.79A 2qqgA-3iv0A:
undetectable		 2qqgA-3iv0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p PROTEIN TRANSPORT
PROTEIN SEC39

(Saccharomyces
cerevisiae) 		PF08314
(Sec39) 		3 PHE D 241
PHE D 236
PHE D 231
 None
 0.64A 2qqgA-3k8pD:
undetectable		 2qqgA-3k8pD:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 CUBILIN

(Homo sapiens) 		PF00431
(CUB) 		3 PHE B1176
PHE B1270
PHE B1207
 None
 0.84A 2qqgA-3kq4B:
undetectable		 2qqgA-3kq4B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		3 PHE A 217
PHE A 129
PHE A 128
 None
 0.86A 2qqgA-3kt4A:
undetectable		 2qqgA-3kt4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxy EXOENZYME S
SYNTHESIS PROTEIN C
EXSE

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF05932
(CesT)
no annotation 		3 PHE A  14
PHE T  23
PHE A  35
 None
 0.82A 2qqgA-3kxyA:
undetectable		 2qqgA-3kxyA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		3 PHE A 194
PHE A 350
PHE A 349
 None
 0.86A 2qqgA-3mpnA:
undetectable		 2qqgA-3mpnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myu HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
genitalium) 		PF06646
(Mycoplasma_p37) 		3 PHE A 328
PHE A  55
PHE A  52
 None
 0.49A 2qqgA-3myuA:
undetectable		 2qqgA-3myuA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		3 PHE A 293
PHE A 231
PHE A 232
 None
 0.76A 2qqgA-3nx3A:
undetectable		 2qqgA-3nx3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		3 PHE A 313
PHE A 210
PHE A 205
 None
 0.87A 2qqgA-3p1vA:
undetectable		 2qqgA-3p1vA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q35 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		3 PHE B 116
PHE B 180
PHE B 183
 None
 0.83A 2qqgA-3q35B:
undetectable		 2qqgA-3q35B:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbt GLUTATHIONE
TRANSFERASE O1

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 PHE A 120
PHE A 149
PHE A 201
 None
 0.87A 2qqgA-3rbtA:
undetectable		 2qqgA-3rbtA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 PHE A 423
PHE A 355
PHE A 357
 None
 0.78A 2qqgA-3txoA:
undetectable		 2qqgA-3txoA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 PHE A 286
PHE A 315
PHE A 413
 None
 0.87A 2qqgA-3ux1A:
undetectable		 2qqgA-3ux1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		3 PHE A 109
PHE A 212
PHE A 209
 None
 0.79A 2qqgA-3v8dA:
undetectable		 2qqgA-3v8dA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		3 PHE A 275
PHE A 175
PHE A 170
 NHE  A 401 ( 4.9A)
None
None
 0.67A 2qqgA-3wibA:
undetectable		 2qqgA-3wibA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acz ENDO-ALPHA-MANNOSIDA
SE

(Bacteroides
thetaiotaomicron) 		PF16317
(Glyco_hydro_99) 		3 PHE B 181
PHE B 151
PHE B 190
 None
 0.87A 2qqgA-4aczB:
undetectable		 2qqgA-4aczB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR

(Homo sapiens) 		PF01462
(LRRNT)
PF12369
(GnHR_trans)
PF13306
(LRR_5) 		3 PHE X  53
PHE X  66
PHE X  69
 None
 0.66A 2qqgA-4ay9X:
undetectable		 2qqgA-4ay9X:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmr GLYCOSYL
HYDROLASE/DEACETYLAS
E FAMILY PROTEIN

(Pyrococcus sp.
ST04) 		no annotation 3 PHE A 134
PHE A 149
PHE A 174
 None
 0.81A 2qqgA-4cmrA:
undetectable		 2qqgA-4cmrA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		3 PHE A 307
PHE A 312
PHE A 417
 None
 0.85A 2qqgA-4cp8A:
undetectable		 2qqgA-4cp8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df9 PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		3 PHE A 313
PHE A 210
PHE A 205
 None
 0.85A 2qqgA-4df9A:
undetectable		 2qqgA-4df9A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es4 PUTATIVE CYCLIC
DI-GMP REGULATOR
CDGR

(Escherichia
coli) 		PF00563
(EAL) 		3 PHE A 178
PHE A 213
PHE A 215
 None
 0.62A 2qqgA-4es4A:
undetectable		 2qqgA-4es4A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8n CONJUGATED
POLYKETONE REDUCTASE
C2

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		3 PHE A 214
PHE A 300
PHE A 304
 NDP  A3001 (-3.2A)
NDP  A3001 ( 4.9A)
None
 0.84A 2qqgA-4h8nA:
undetectable		 2qqgA-4h8nA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00814
(Peptidase_M22) 		3 PHE A 178
PHE A 320
PHE A 349
 None
 0.78A 2qqgA-4k25A:
undetectable		 2qqgA-4k25A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 PHE B 494
PHE B 558
PHE B 561
 None
 0.85A 2qqgA-4l37B:
undetectable		 2qqgA-4l37B:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfa PROTEIN CASC5

(Homo sapiens) 		no annotation 3 PHE A2134
PHE A2121
PHE A2123
 None
 0.86A 2qqgA-4nfaA:
undetectable		 2qqgA-4nfaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5

(Brucella
melitensis) 		PF00496
(SBP_bac_5) 		3 PHE A 117
PHE A 171
PHE A 173
 None
 0.78A 2qqgA-4onyA:
undetectable		 2qqgA-4onyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 PHE A 691
PHE A 621
PHE A 623
 None
 0.81A 2qqgA-4otdA:
undetectable		 2qqgA-4otdA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 PHE A 407
PHE A 339
PHE A 341
 None
 0.83A 2qqgA-4ra4A:
undetectable		 2qqgA-4ra4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rso CAPSID PROTEIN VP1

(Non-human
primate
Adeno-associated
virus) 		PF00740
(Parvo_coat) 		3 PHE A 286
PHE A 315
PHE A 413
 None
 0.82A 2qqgA-4rsoA:
undetectable		 2qqgA-4rsoA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybg PROTEIN MAELSTROM

(Drosophila
melanogaster) 		PF13017
(Maelstrom) 		3 PHE A 274
PHE A 279
PHE A 280
 None
 0.60A 2qqgA-4ybgA:
undetectable		 2qqgA-4ybgA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yit MEGANUCLEASE I-AABMI

(Gremmeniella
abietina) 		PF00961
(LAGLIDADG_1) 		3 PHE A 211
PHE A 239
PHE A 240
 None
 0.84A 2qqgA-4yitA:
undetectable		 2qqgA-4yitA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		3 PHE A 272
PHE A 220
PHE A  68
 None
 0.85A 2qqgA-4zadA:
undetectable		 2qqgA-4zadA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		3 PHE A1094
PHE A 943
PHE A 945
 None
 0.70A 2qqgA-5amqA:
undetectable		 2qqgA-5amqA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cl2 SPORULATION-CONTROL
PROTEIN SPO0M

(Bacillus
subtilis) 		PF07070
(Spo0M) 		3 PHE A 195
PHE A 175
PHE A 177
 None
 0.66A 2qqgA-5cl2A:
undetectable		 2qqgA-5cl2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		3 PHE A 466
PHE A 349
PHE A 351
 None
 0.69A 2qqgA-5gmhA:
undetectable		 2qqgA-5gmhA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		3 PHE A  71
PHE A 257
PHE A  54
 None
 0.82A 2qqgA-5hsxA:
undetectable		 2qqgA-5hsxA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 PHE A 203
PHE A 344
PHE A 277
 None
 0.82A 2qqgA-5jm7A:
undetectable		 2qqgA-5jm7A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5keu TAURINE DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		3 PHE A  71
PHE A 257
PHE A  54
 None
 0.83A 2qqgA-5keuA:
undetectable		 2qqgA-5keuA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Acidaminococcus
sp. BV3L6) 		no annotation 3 PHE A 632
PHE A 683
PHE A 679
 None
 0.82A 2qqgA-5kk5A:
undetectable		 2qqgA-5kk5A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkf POLYCYSTIN-2

(Homo sapiens) 		PF08016
(PKD_channel) 		3 PHE A 637
PHE A 608
PHE A 605
 None
None
PLM  A1009 ( 4.6A)
 0.88A 2qqgA-5mkfA:
undetectable		 2qqgA-5mkfA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8o MITOCHONDRIAL IMPORT
RECEPTOR SUBUNIT
TOM40

(Neurospora
crassa) 		PF01459
(Porin_3) 		3 PHE A 155
PHE A  29
PHE A  26
 None
 0.76A 2qqgA-5o8oA:
undetectable		 2qqgA-5o8oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 PHE A 384
PHE A 895
PHE A 897
 None
 0.73A 2qqgA-5um6A:
2.1		 2qqgA-5um6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 PHE A 897
PHE A 386
PHE A 384
 None
 0.83A 2qqgA-5um6A:
2.1		 2qqgA-5um6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 3 PHE B2606
PHE B2632
PHE B2629
 None
 0.85A 2qqgA-5wfcB:
undetectable		 2qqgA-5wfcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvr KLLA0C04147P

(Kluyveromyces
lactis) 		PF01237
(Oxysterol_BP) 		3 PHE A1205
PHE A 943
PHE A 942
 None
 0.82A 2qqgA-5wvrA:
undetectable		 2qqgA-5wvrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3h URACIL-DNA
GLYCOSYLASE

(Nitratifractor
salsuginis) 		no annotation 3 PHE A 207
PHE A  92
PHE A 159
 None
 0.85A 2qqgA-5x3hA:
2.0		 2qqgA-5x3hA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmg UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 3 PHE A 223
PHE A  82
PHE A 187
 None
 0.86A 2qqgA-5xmgA:
undetectable		 2qqgA-5xmgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnd PARVALBUMIN BETA

(Scomber
japonicus) 		no annotation 3 PHE A  25
PHE A  30
PHE A  31
 None
 0.87A 2qqgA-5xndA:
undetectable		 2qqgA-5xndA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		3 PHE A1491
PHE A1463
PHE A1459
 None
 0.70A 2qqgA-5xsyA:
undetectable		 2qqgA-5xsyA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 3 PHE A1339
PHE A1311
PHE A1307
 None
 0.81A 2qqgA-6a91A:
undetectable		 2qqgA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c13 -

(-) 		no annotation 3 PHE A1215
PHE A1223
PHE A1225
 None
 0.71A 2qqgA-6c13A:
undetectable		 2qqgA-6c13A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 3 PHE A  21
PHE A  54
PHE A  56
 None
 0.82A 2qqgA-6eojA:
undetectable		 2qqgA-6eojA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 3 PHE F 245
PHE F 393
PHE F 394
 None
 0.82A 2qqgA-6f0kF:
undetectable		 2qqgA-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
11, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		3 PHE h  21
PHE g  60
PHE g  64
 None
 0.87A 2qqgA-6g2jh:
undetectable		 2qqgA-6g2jh:
undetectable