SIMILAR PATTERNS OF AMINO ACIDS FOR 2QQC_I_AG2I671_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		4 LEU A 139
LEU A  80
MET A 159
GLN A 182
 None
 0.90A 2qqcG-1bg6A:
0.0
2qqcJ-1bg6A:
0.0		 2qqcG-1bg6A:
11.90
2qqcJ-1bg6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhw XYLOSE ISOMERASE

(Actinoplanes
missouriensis) 		PF01261
(AP_endonuc_2) 		4 LEU A 134
LEU A 162
ILE A 116
MET A 123
 None
 0.99A 2qqcG-1bhwA:
0.0
2qqcJ-1bhwA:
0.0		 2qqcG-1bhwA:
10.34
2qqcJ-1bhwA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecm ENDO-OXABICYCLIC
TRANSITION STATE
ANALOGUE

(Escherichia
coli) 		PF01817
(CM_2) 		4 LEU A  79
ASP A  83
LEU A  86
ARG A  29
 None
 0.92A 2qqcG-1ecmA:
undetectable
2qqcJ-1ecmA:
undetectable		 2qqcG-1ecmA:
18.52
2qqcJ-1ecmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		4 LEU A 316
LEU A 319
ILE A  45
GLN A 299
 None
 0.99A 2qqcG-1fhuA:
0.0
2qqcJ-1fhuA:
0.0		 2qqcG-1fhuA:
11.44
2qqcJ-1fhuA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 LEU 1 343
ASP 1 252
LEU 1 188
ARG 1 248
 None
 0.73A 2qqcG-1gt91:
0.0
2qqcJ-1gt91:
0.0		 2qqcG-1gt91:
9.86
2qqcJ-1gt91:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 LEU P  40
ASP P 234
LEU P 232
ARG P  20
 None
 1.04A 2qqcG-1h71P:
undetectable
2qqcJ-1h71P:
0.0		 2qqcG-1h71P:
7.38
2qqcJ-1h71P:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hna GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  20
LEU A  76
ILE A  69
MET A   2
 None
 0.98A 2qqcG-1hnaA:
undetectable
2qqcJ-1hnaA:
undetectable		 2qqcG-1hnaA:
17.53
2qqcJ-1hnaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		4 LEU A  35
LEU A  45
ILE A  52
MET A  95
 None
None
None
NAG  A 461 (-3.7A)
 0.92A 2qqcG-1ituA:
0.0
2qqcJ-1ituA:
0.0		 2qqcG-1ituA:
10.03
2qqcJ-1ituA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE

(Pyrococcus
furiosus) 		PF00152
(tRNA-synt_2) 		4 LEU A 255
LEU A 247
ILE A  45
GLN A  81
 None
 0.91A 2qqcG-1nnhA:
undetectable
2qqcJ-1nnhA:
0.2		 2qqcG-1nnhA:
12.85
2qqcJ-1nnhA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ors 33H1 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP B  90
LEU B  18
ILE B  68
ARG B  67
 None
 0.99A 2qqcG-1orsB:
0.0
2qqcJ-1orsB:
0.0		 2qqcG-1orsB:
11.06
2qqcJ-1orsB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
9 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF08992
(QH-AmDH_gamma)
no annotation 		4 LEU C  51
ASP C  39
LEU B 327
ARG B   9
 None
None
TRW  C  43 ( 4.2A)
None
 0.97A 2qqcG-1pbyC:
undetectable
2qqcJ-1pbyC:
undetectable		 2qqcG-1pbyC:
22.67
2qqcJ-1pbyC:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		4 LEU L  50
ASP H 105
GLN L  38
ARG H  98
 None
 0.83A 2qqcG-1qfwL:
undetectable
2qqcJ-1qfwL:
undetectable		 2qqcG-1qfwL:
13.16
2qqcJ-1qfwL:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		4 LEU A 728
ILE A 748
MET A 741
GLN A 742
 None
 0.99A 2qqcG-1qu2A:
undetectable
2qqcJ-1qu2A:
undetectable		 2qqcG-1qu2A:
5.76
2qqcJ-1qu2A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 LEU A 302
ASP A 301
GLN A 313
ARG A 265
 None
 1.02A 2qqcG-1r30A:
0.0
2qqcJ-1r30A:
undetectable		 2qqcG-1r30A:
9.88
2qqcJ-1r30A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5t DIHYDRODIPICOLINATE
SYNTHASE

(Escherichia
coli) 		PF00701
(DHDPS) 		4 LEU A 236
ASP A 188
LEU A 243
MET A 214
 None
 1.05A 2qqcG-1s5tA:
undetectable
2qqcJ-1s5tA:
undetectable		 2qqcG-1s5tA:
14.22
2qqcJ-1s5tA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 LEU A 532
ASP A 441
LEU A 377
ARG A 437
 None
 0.82A 2qqcG-1t1eA:
undetectable
2qqcJ-1t1eA:
undetectable		 2qqcG-1t1eA:
7.32
2qqcJ-1t1eA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		4 LEU A  73
LEU A  36
ILE A  93
GLN A  99
 None
 1.04A 2qqcG-1td2A:
undetectable
2qqcJ-1td2A:
undetectable		 2qqcG-1td2A:
10.60
2qqcJ-1td2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 168
ASP A 172
LEU A 175
GLN A 296
ARG A 126
 None
 1.29A 2qqcG-1tltA:
undetectable
2qqcJ-1tltA:
undetectable		 2qqcG-1tltA:
13.08
2qqcJ-1tltA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		4 LEU A  30
ASP A  29
ILE A 359
GLN A  21
 None
 0.96A 2qqcG-1tt4A:
undetectable
2qqcJ-1tt4A:
undetectable		 2qqcG-1tt4A:
9.69
2qqcJ-1tt4A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1

(Homo sapiens) 		PF07679
(I-set) 		4 LEU A 108
ASP A  87
GLN A  29
ARG A  65
 None
 1.00A 2qqcG-1u2hA:
undetectable
2qqcJ-1u2hA:
undetectable		 2qqcG-1u2hA:
17.17
2qqcJ-1u2hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		4 LEU A  94
ASP A  96
LEU A  97
ARG A 271
 None
SAM  A3142 (-3.5A)
None
SAM  A3142 (-3.2A)
 0.97A 2qqcG-1wg8A:
undetectable
2qqcJ-1wg8A:
undetectable		 2qqcG-1wg8A:
13.25
2qqcJ-1wg8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yac YCAC GENE PRODUCT

(Escherichia
coli) 		PF00857
(Isochorismatase) 		4 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.02A 2qqcG-1yacA:
undetectable
2qqcJ-1yacA:
undetectable		 2qqcG-1yacA:
16.67
2qqcJ-1yacA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g42 HYPOTHETICAL PROTEIN
TM_0693

(Thermotoga
maritima) 		no annotation 4 LEU A  52
ASP A  48
LEU A  45
ARG A  29
 None
 0.74A 2qqcG-2g42A:
undetectable
2qqcJ-2g42A:
undetectable		 2qqcG-2g42A:
24.00
2qqcJ-2g42A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		4 LEU D 373
ASP D 369
LEU D 366
ILE D 343
 None
 0.92A 2qqcG-2gafD:
undetectable
2qqcJ-2gafD:
undetectable		 2qqcG-2gafD:
9.87
2qqcJ-2gafD:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 LEU A 467
ASP A 466
LEU A 289
ARG A 297
 None
 0.97A 2qqcG-2jgpA:
undetectable
2qqcJ-2jgpA:
1.1		 2qqcG-2jgpA:
8.53
2qqcJ-2jgpA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k6b PROGRAMMED CELL
DEATH PROTEIN 5

(Homo sapiens) 		PF01984
(dsDNA_bind) 		4 LEU A  83
LEU A  48
ILE A  75
GLN A  82
 None
 1.02A 2qqcG-2k6bA:
undetectable
2qqcJ-2k6bA:
undetectable		 2qqcG-2k6bA:
17.82
2qqcJ-2k6bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc3 APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 LEU A 155
ASP A 151
LEU A 148
GLN A 101
 None
 0.89A 2qqcG-2kc3A:
undetectable
2qqcJ-2kc3A:
undetectable		 2qqcG-2kc3A:
14.92
2qqcJ-2kc3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2s PUTATIVE
OXIDOREDUCTASE

(Pectobacterium
atrosepticum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 176
ASP A 219
ILE A 334
GLN A 328
 None
None
None
EDO  A 341 (-4.2A)
 1.02A 2qqcG-2p2sA:
undetectable
2qqcJ-2p2sA:
undetectable		 2qqcG-2p2sA:
9.82
2qqcJ-2p2sA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 LEU A 199
ASP A 145
ILE A 333
ARG A 277
 None
 0.95A 2qqcG-2p3xA:
undetectable
2qqcJ-2p3xA:
undetectable		 2qqcG-2p3xA:
9.23
2qqcJ-2p3xA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbg 6-PHOSPHO-BETA-D-GAL
ACTOSIDASE

(Lactococcus
lactis) 		PF00232
(Glyco_hydro_1) 		4 LEU A 284
ASP A 280
LEU A 276
ARG A 132
 None
 0.65A 2qqcG-2pbgA:
undetectable
2qqcJ-2pbgA:
undetectable		 2qqcG-2pbgA:
8.37
2qqcJ-2pbgA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		4 LEU A 189
ASP A 243
LEU A 244
ILE A  54
 None
 1.04A 2qqcG-2qmiA:
undetectable
2qqcJ-2qmiA:
undetectable		 2qqcG-2qmiA:
8.95
2qqcJ-2qmiA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		4 LEU A  40
ASP A  36
LEU A  33
ARG A 404
 None
 0.76A 2qqcG-2ynkA:
undetectable
2qqcJ-2ynkA:
undetectable		 2qqcG-2ynkA:
7.69
2qqcJ-2ynkA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		4 LEU A  89
LEU A 114
ILE A  64
MET A  21
 None
 0.93A 2qqcG-3bxzA:
undetectable
2qqcJ-3bxzA:
undetectable		 2qqcG-3bxzA:
7.81
2qqcJ-3bxzA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		4 LEU A 312
LEU A 414
ILE A 478
MET A 547
 None
 1.02A 2qqcG-3gf7A:
undetectable
2qqcJ-3gf7A:
undetectable		 2qqcG-3gf7A:
7.13
2qqcJ-3gf7A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hb7 ISOCHORISMATASE
HYDROLASE

(Alkaliphilus
metalliredigens) 		PF00857
(Isochorismatase) 		4 LEU A  12
ASP A  14
GLN A  55
ARG A  68
 None
 0.87A 2qqcG-3hb7A:
undetectable
2qqcJ-3hb7A:
undetectable		 2qqcG-3hb7A:
12.18
2qqcJ-3hb7A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A  81
ASP A  61
GLN A  55
ARG A  26
 None
 1.07A 2qqcG-3hurA:
undetectable
2qqcJ-3hurA:
undetectable		 2qqcG-3hurA:
10.83
2qqcJ-3hurA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 LEU A 218
ASP A 194
ILE A  74
GLN A  94
 None
 1.00A 2qqcG-3kh8A:
undetectable
2qqcJ-3kh8A:
undetectable		 2qqcG-3kh8A:
10.65
2qqcJ-3kh8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 ASP B 182
LEU B 183
ILE B  60
ARG B  33
 SAM  B 301 (-3.1A)
SAM  B 301 (-4.0A)
SAM  B 301 (-4.2A)
SAM  B 301 ( 4.7A)
 1.07A 2qqcG-3lcvB:
undetectable
2qqcJ-3lcvB:
undetectable		 2qqcG-3lcvB:
11.07
2qqcJ-3lcvB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 LEU A 562
LEU A 559
ILE A 511
GLN A 464
 None
 1.02A 2qqcG-3lk6A:
undetectable
2qqcJ-3lk6A:
undetectable		 2qqcG-3lk6A:
5.84
2qqcJ-3lk6A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 319
LEU A 312
ILE A  69
MET A 200
 None
 1.06A 2qqcG-3mjfA:
undetectable
2qqcJ-3mjfA:
undetectable		 2qqcG-3mjfA:
8.12
2qqcJ-3mjfA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 202
ASP A 201
GLN A 336
ARG A 185
 None
 1.02A 2qqcG-3na0A:
undetectable
2qqcJ-3na0A:
undetectable		 2qqcG-3na0A:
7.53
2qqcJ-3na0A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		4 LEU A   3
LEU A  61
ILE A 187
GLN A  50
 None
 1.06A 2qqcG-3npkA:
undetectable
2qqcJ-3npkA:
undetectable		 2qqcG-3npkA:
12.14
2qqcJ-3npkA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		4 LEU A 255
LEU A 247
ILE A  45
GLN A  81
 None
 0.94A 2qqcG-3p8tA:
undetectable
2qqcJ-3p8tA:
0.3		 2qqcG-3p8tA:
11.34
2qqcJ-3p8tA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb0 DIHYDRODIPICOLINATE
SYNTHASE

(Thermotoga
maritima) 		PF00701
(DHDPS) 		4 LEU A 239
ASP A 191
MET A 217
GLN A 216
 None
 0.97A 2qqcG-3pb0A:
undetectable
2qqcJ-3pb0A:
undetectable		 2qqcG-3pb0A:
11.45
2qqcJ-3pb0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb0 DIHYDRODIPICOLINATE
SYNTHASE

(Thermotoga
maritima) 		PF00701
(DHDPS) 		4 LEU A 239
LEU A 246
MET A 217
GLN A 216
 None
 0.75A 2qqcG-3pb0A:
undetectable
2qqcJ-3pb0A:
undetectable		 2qqcG-3pb0A:
11.45
2qqcJ-3pb0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 LEU B 325
ASP B 329
LEU B 332
ARG B 333
 None
 0.91A 2qqcG-3pdiB:
undetectable
2qqcJ-3pdiB:
undetectable		 2qqcG-3pdiB:
8.78
2qqcJ-3pdiB:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 311
LEU A 358
ILE A 372
MET A 339
 None
 1.04A 2qqcG-3pfeA:
undetectable
2qqcJ-3pfeA:
undetectable		 2qqcG-3pfeA:
7.25
2qqcJ-3pfeA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzs PYRIDOXAMINE KINASE

(Yersinia pestis) 		PF08543
(Phos_pyr_kin) 		4 LEU A  72
LEU A  35
ILE A  92
GLN A  98
 None
 1.04A 2qqcG-3pzsA:
undetectable
2qqcJ-3pzsA:
undetectable		 2qqcG-3pzsA:
11.31
2qqcJ-3pzsA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmw THIOESTERASE

(Streptomyces
coelicolor) 		PF00975
(Thioesterase) 		4 ASP A 186
LEU A 183
MET A 108
ARG A  69
 None
 1.02A 2qqcG-3qmwA:
undetectable
2qqcJ-3qmwA:
undetectable		 2qqcG-3qmwA:
10.77
2qqcJ-3qmwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 ASP A 462
LEU A 458
ILE A 467
ARG A   8
 None
 0.97A 2qqcG-3qp9A:
undetectable
2qqcJ-3qp9A:
undetectable		 2qqcG-3qp9A:
6.34
2qqcJ-3qp9A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 LEU A  82
LEU A  65
ILE A  92
GLN A 100
 None
 1.01A 2qqcG-3t6qA:
undetectable
2qqcJ-3t6qA:
undetectable		 2qqcG-3t6qA:
6.44
2qqcJ-3t6qA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb2 1-CYS PEROXIREDOXIN

(Plasmodium
yoelii) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A 161
LEU A  68
ILE A  29
GLN A 165
 None
 1.05A 2qqcG-3tb2A:
undetectable
2qqcJ-3tb2A:
undetectable		 2qqcG-3tb2A:
13.74
2qqcJ-3tb2A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uuf LIP1, SECRETORY
LIPASE (FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		4 LEU A 179
ASP A 183
LEU A 186
GLN A 139
 None
 0.92A 2qqcG-3uufA:
undetectable
2qqcJ-3uufA:
undetectable		 2qqcG-3uufA:
12.74
2qqcJ-3uufA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A1729
LEU A1770
ILE A1758
MET A1744
 None
 1.07A 2qqcG-3vkgA:
undetectable
2qqcJ-3vkgA:
undetectable		 2qqcG-3vkgA:
2.22
2qqcJ-3vkgA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 4 LEU A 157
LEU A 164
ILE A 136
GLN A 142
 None
 0.86A 2qqcG-3w36A:
undetectable
2qqcJ-3w36A:
undetectable		 2qqcG-3w36A:
8.27
2qqcJ-3w36A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 LEU C 343
ASP C 385
LEU C 384
ILE C  19
 None
 1.01A 2qqcG-4bujC:
undetectable
2qqcJ-4bujC:
undetectable		 2qqcG-4bujC:
9.77
2qqcJ-4bujC:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
PROTEASOME CHAPERONE
1

(Saccharomyces
cerevisiae) 		PF09754
(PAC2)
PF10450
(POC1) 		4 LEU P  70
ASP P  37
GLN P  85
ARG O 152
 None
 1.07A 2qqcG-4g4sP:
undetectable
2qqcJ-4g4sP:
undetectable		 2qqcG-4g4sP:
13.60
2qqcJ-4g4sP:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Bacillus
anthracis) 		PF00144
(Beta-lactamase) 		4 LEU A 208
ASP A 205
LEU A 201
GLN A 295
 None
 0.98A 2qqcG-4gb7A:
undetectable
2qqcJ-4gb7A:
undetectable		 2qqcG-4gb7A:
13.85
2qqcJ-4gb7A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE

(Oryza sativa) 		PF03098
(An_peroxidase) 		4 LEU A 530
ASP A 528
LEU A 527
ILE A 519
 None
 1.03A 2qqcG-4kvlA:
undetectable
2qqcJ-4kvlA:
undetectable		 2qqcG-4kvlA:
6.61
2qqcJ-4kvlA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Legionella
pneumophila) 		PF00701
(DHDPS) 		4 LEU A 235
ASP A 187
LEU A 242
MET A 213
 None
 0.98A 2qqcG-4nq1A:
undetectable
2qqcJ-4nq1A:
undetectable		 2qqcG-4nq1A:
12.59
2qqcJ-4nq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu2 ANTIFREEZE PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		4 LEU A  67
LEU A  64
ILE A 195
ARG A 149
 None
 1.07A 2qqcG-4nu2A:
undetectable
2qqcJ-4nu2A:
undetectable		 2qqcG-4nu2A:
18.24
2qqcJ-4nu2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		4 ASP A 219
ILE A 276
GLN A 265
ARG A  24
 None
 0.77A 2qqcG-4pqgA:
undetectable
2qqcJ-4pqgA:
undetectable		 2qqcG-4pqgA:
7.85
2qqcJ-4pqgA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9m SPERMIDINE
N(1)-ACETYLTRANSFERA
SE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		4 ASP A  16
LEU A  12
GLN A  22
ARG A  10
 None
 1.05A 2qqcG-4r9mA:
undetectable
2qqcJ-4r9mA:
undetectable		 2qqcG-4r9mA:
13.94
2qqcJ-4r9mA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 LEU B 407
LEU B 372
ILE B 311
MET B 340
 None
 1.03A 2qqcG-4trqB:
undetectable
2qqcJ-4trqB:
undetectable		 2qqcG-4trqB:
9.93
2qqcJ-4trqB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		4 LEU A  24
ASP A  19
ILE A  88
ARG A  84
 None
 1.07A 2qqcG-4wh0A:
undetectable
2qqcJ-4wh0A:
undetectable		 2qqcG-4wh0A:
11.94
2qqcJ-4wh0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 120
ASP A  99
GLN A  40
ARG A  75
 None
 0.99A 2qqcG-4y61A:
undetectable
2qqcJ-4y61A:
undetectable		 2qqcG-4y61A:
8.83
2qqcJ-4y61A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 ASP A 168
ILE A 335
GLN A 206
ARG A 143
 None
 1.07A 2qqcG-4y9lA:
undetectable
2qqcJ-4y9lA:
undetectable		 2qqcG-4y9lA:
6.64
2qqcJ-4y9lA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 LEU A  70
ASP A 339
LEU A 308
ARG A 296
 None
 0.92A 2qqcG-4yyfA:
undetectable
2qqcJ-4yyfA:
undetectable		 2qqcG-4yyfA:
9.12
2qqcJ-4yyfA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2e DNA GYRASE SUBUNIT A

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV) 		4 LEU A 447
ASP A 450
ILE A 464
ARG A 460
 None
 0.85A 2qqcG-4z2eA:
undetectable
2qqcJ-4z2eA:
undetectable		 2qqcG-4z2eA:
9.05
2qqcJ-4z2eA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo3 ACYLHOMOSERINE
LACTONASE

(Chryseobacterium
sp. StRB126) 		PF00753
(Lactamase_B) 		4 ASP A 263
LEU A 306
ILE A  91
ARG A  86
 None
 1.04A 2qqcG-4zo3A:
undetectable
2qqcJ-4zo3A:
undetectable		 2qqcG-4zo3A:
11.24
2qqcJ-4zo3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 LEU A 688
LEU A 675
MET A  73
GLN A 692
 None
 1.07A 2qqcG-4zr5A:
undetectable
2qqcJ-4zr5A:
undetectable		 2qqcG-4zr5A:
5.24
2qqcJ-4zr5A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1v GLOBIN

(Chloroflexus
aurantiacus) 		PF01152
(Bac_globin) 		4 LEU A  52
LEU A  96
ILE A  22
GLN A  48
 None
 0.95A 2qqcG-5d1vA:
undetectable
2qqcJ-5d1vA:
undetectable		 2qqcG-5d1vA:
18.10
2qqcJ-5d1vA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		4 LEU A 417
LEU A 414
ILE A 471
GLN A 465
 None
 1.07A 2qqcG-5djsA:
undetectable
2qqcJ-5djsA:
undetectable		 2qqcG-5djsA:
8.65
2qqcJ-5djsA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		4 ASP A 219
ILE A 276
GLN A 265
ARG A  24
 None
 1.01A 2qqcG-5e9uA:
undetectable
2qqcJ-5e9uA:
undetectable		 2qqcG-5e9uA:
7.36
2qqcJ-5e9uA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP B  86
LEU B  82
ILE B  67
ARG B  66
 None
 1.04A 2qqcG-5f9wB:
undetectable
2qqcJ-5f9wB:
undetectable		 2qqcG-5f9wB:
10.67
2qqcJ-5f9wB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		4 LEU A  44
LEU A 427
ILE A 433
GLN A  58
 None
 1.02A 2qqcG-5g0aA:
undetectable
2qqcJ-5g0aA:
undetectable		 2qqcG-5g0aA:
8.97
2qqcJ-5g0aA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 LEU A 681
ASP A 678
LEU A 674
ARG A 737
 None
 0.78A 2qqcG-5gl7A:
undetectable
2qqcJ-5gl7A:
undetectable		 2qqcG-5gl7A:
8.50
2qqcJ-5gl7A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 LEU A  71
ILE A  83
MET A  78
ARG A  82
 None
 1.06A 2qqcG-5gweA:
undetectable
2qqcJ-5gweA:
undetectable		 2qqcG-5gweA:
9.60
2qqcJ-5gweA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL

(Caenorhabditis
elegans) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF16526
(CLZ) 		4 LEU A 216
ASP A 212
LEU A 209
ARG A 280
 None
 0.78A 2qqcG-5h3oA:
undetectable
2qqcJ-5h3oA:
undetectable		 2qqcG-5h3oA:
6.38
2qqcJ-5h3oA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx9 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		4 LEU A  50
ASP A  51
GLN A 191
ARG A 254
 None
 0.96A 2qqcG-5hx9A:
undetectable
2qqcJ-5hx9A:
undetectable		 2qqcG-5hx9A:
12.64
2qqcJ-5hx9A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4a TRNA NUCLEASE CDIA

(Burkholderia
pseudomallei) 		no annotation 4 LEU A 272
LEU A 265
ILE A 257
MET A 245
 None
 1.02A 2qqcG-5j4aA:
undetectable
2qqcJ-5j4aA:
undetectable		 2qqcG-5j4aA:
18.01
2qqcJ-5j4aA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5juf TRANSCRIPTIONAL
REGULATOR

(Streptococcus
thermophilus) 		PF01381
(HTH_3) 		4 LEU A 210
ASP A 209
LEU A 163
ILE A 187
 None
 1.00A 2qqcG-5jufA:
undetectable
2qqcJ-5jufA:
undetectable		 2qqcG-5jufA:
9.35
2qqcJ-5jufA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 224
LEU A 231
ILE A 273
GLN A 296
 None
6Q7  A 501 ( 4.3A)
6Q7  A 501 ( 3.9A)
None
 0.94A 2qqcG-5k13A:
undetectable
2qqcJ-5k13A:
undetectable		 2qqcG-5k13A:
14.42
2qqcJ-5k13A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		4 LEU A  89
LEU A 114
ILE A  64
MET A  21
 None
 1.00A 2qqcG-5k9tA:
undetectable
2qqcJ-5k9tA:
undetectable		 2qqcG-5k9tA:
7.16
2qqcJ-5k9tA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 LEU A 645
ASP A 644
ILE A 513
ARG A 516
 None
 0.98A 2qqcG-5tusA:
undetectable
2qqcJ-5tusA:
undetectable		 2qqcG-5tusA:
5.69
2qqcJ-5tusA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 4 ASP A 270
LEU A 269
ILE A 276
ARG A 260
 None
 0.82A 2qqcG-5veuA:
undetectable
2qqcJ-5veuA:
undetectable		 2qqcG-5veuA:
7.61
2qqcJ-5veuA:
12.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vxr MAB24 VARIABLE HEAVY
CHAIN,MAB24 VARIABLE
HEAVY CHAIN

(Mus musculus) 		no annotation 4 ASP H  89
LEU H  18
ILE H  67
ARG H  66
 None
 0.87A 2qqcG-5vxrH:
undetectable
2qqcJ-5vxrH:
undetectable		 2qqcG-5vxrH:
30.43
2qqcJ-5vxrH:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 FIBROBLAST GROWTH
FACTOR 23
KLOTHO

(Homo sapiens) 		no annotation 4 ASP A 756
LEU A 753
ILE A 812
ARG B 198
 None
 0.67A 2qqcG-5w21A:
undetectable
2qqcJ-5w21A:
undetectable		 2qqcG-5w21A:
18.75
2qqcJ-5w21A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix)
PF04939
(RRS1) 		4 LEU A 230
ASP A 231
ILE B  50
ARG B  46
 None
 1.05A 2qqcG-5wxlA:
undetectable
2qqcJ-5wxlA:
undetectable		 2qqcG-5wxlA:
11.97
2qqcJ-5wxlA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 LEU A  44
ILE A  56
MET A  51
ARG A  55
 None
 1.05A 2qqcG-5xjnA:
undetectable
2qqcJ-5xjnA:
undetectable		 2qqcG-5xjnA:
9.07
2qqcJ-5xjnA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yti FLAGELLAR HOOK
ASSOCIATED PROTEIN
TYPE 3 FLGL

(Legionella
pneumophila) 		no annotation 4 LEU A 110
LEU A 117
ILE A 331
GLN A  96
 None
 1.06A 2qqcG-5ytiA:
undetectable
2qqcJ-5ytiA:
undetectable		 2qqcG-5ytiA:
17.50
2qqcJ-5ytiA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7q FLAGELLIN

(Bacillus cereus) 		no annotation 4 LEU A  73
ASP A  77
LEU A  80
GLN A 207
 None
 0.88A 2qqcG-5z7qA:
undetectable
2qqcJ-5z7qA:
undetectable		 2qqcG-5z7qA:
20.73
2qqcJ-5z7qA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 4 ASP A 222
ILE A 247
GLN A 229
ARG A 257
 None
 1.01A 2qqcG-6b2wA:
undetectable
2qqcJ-6b2wA:
undetectable		 2qqcG-6b2wA:
21.33
2qqcJ-6b2wA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bn1 SCAFFOLD PROTEIN
SALVADOR
SERINE/THREONINE-PRO
TEIN KINASE HIPPO

(Drosophila
melanogaster) 		no annotation 4 LEU B 563
ASP B 567
LEU B 570
MET A 650
 None
 0.87A 2qqcG-6bn1B:
undetectable
2qqcJ-6bn1B:
undetectable		 2qqcG-6bn1B:
21.79
2qqcJ-6bn1B:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT SWP1

(Saccharomyces
cerevisiae) 		no annotation 4 ASP C 119
LEU C 123
ILE C 133
MET C  94
 None
 1.05A 2qqcG-6c26C:
undetectable
2qqcJ-6c26C:
undetectable		 2qqcG-6c26C:
24.00
2qqcJ-6c26C:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 4 LEU A 802
ASP A 827
GLN A 800
ARG A 921
 None
 1.03A 2qqcG-6cipA:
undetectable
2qqcJ-6cipA:
undetectable		 2qqcG-6cipA:
18.75
2qqcJ-6cipA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6coy CHLORIDE CHANNEL
PROTEIN 1

(Homo sapiens) 		no annotation 4 LEU A 143
LEU A 171
ILE A 227
MET A 419
 None
 0.97A 2qqcG-6coyA:
undetectable
2qqcJ-6coyA:
undetectable		 2qqcG-6coyA:
15.71
2qqcJ-6coyA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d72 SPERMIDINE
N1-ACETYLTRANSFERASE

(Yersinia pestis) 		no annotation 4 ASP A  16
LEU A  12
GLN A  22
ARG A  10
 None
 1.07A 2qqcG-6d72A:
undetectable
2qqcJ-6d72A:
undetectable		 2qqcG-6d72A:
23.17
2qqcJ-6d72A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 LEU B  96
ASP B  92
LEU B  89
ARG B  24
 None
 1.02A 2qqcG-6fd2B:
undetectable
2qqcJ-6fd2B:
undetectable		 2qqcG-6fd2B:
15.58
2qqcJ-6fd2B:
22.41