SIMILAR PATTERNS OF AMINO ACIDS FOR 2QO6_A_CHDA130

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		5 TYR B1750
ILE B1755
LEU B1774
ALA B1659
PHE B1758
 None
 1.25A 2qo6A-1a9xB:
undetectable		 2qo6A-1a9xB:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00652
(Ricin_B_lectin) 		5 LEU B 196
ALA B 159
THR B 147
PHE B 223
MET B 238
 None
 1.16A 2qo6A-1abrB:
0.0		 2qo6A-1abrB:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqc PROTEIN
(BETA-MANNANASE)

(Thermobifida
fusca) 		PF00150
(Cellulase) 		5 LEU A  83
LEU A  53
VAL A 113
ASP A  66
PHE A  38
 None
 1.20A 2qo6A-1bqcA:
0.0		 2qo6A-1bqcA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1del DEOXYNUCLEOSIDE
MONOPHOSPHATE KINASE

(Escherichia
virus T4) 		no annotation 5 LEU A  40
ILE A  36
VAL A  79
HIS A 206
ARG A 133
 None
 1.28A 2qo6A-1delA:
0.0		 2qo6A-1delA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 5 TYR A 129
LEU A 133
ILE A 136
LEU A 153
VAL A 117
 None
 1.19A 2qo6A-1dgpA:
undetectable		 2qo6A-1dgpA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 TYR A  63
LEU A 139
ILE A 124
LEU A 123
PHE A  94
 None
 1.28A 2qo6A-1dppA:
undetectable		 2qo6A-1dppA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 LEU A 168
LEU A 200
VAL A  86
PHE A 216
HIS A 176
 None
 1.29A 2qo6A-1jeqA:
0.4		 2qo6A-1jeqA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001

(Methanothermobacter
thermautotrophicus) 		PF02598
(Methyltrn_RNA_3) 		5 LEU A  61
ILE A  57
ALA A  35
VAL A  40
THR A 246
 None
 1.32A 2qo6A-1k3rA:
undetectable		 2qo6A-1k3rA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		5 LEU A  27
ALA A 224
VAL A 221
THR A 235
HIS A 210
 None
None
None
P6G  A 600 ( 4.8A)
FE2  A 500 ( 3.5A)
 1.31A 2qo6A-1lkdA:
undetectable		 2qo6A-1lkdA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU A  77
ILE A  58
LEU A  80
VAL A  97
PHE A  31
 None
 1.34A 2qo6A-1moxA:
undetectable		 2qo6A-1moxA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 TYR A 594
LEU A 589
ILE A 584
LEU A 587
THR A 953
 None
 1.28A 2qo6A-1p2zA:
undetectable		 2qo6A-1p2zA:
9.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		5 TYR A  14
LEU A  18
ALA A  31
HIS A  98
ARG A 120
 None
 1.01A 2qo6A-1p6pA:
16.7		 2qo6A-1p6pA:
64.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		5 TYR A  14
LEU A  18
LEU A  23
ALA A  31
ARG A 120
 None
 1.10A 2qo6A-1p6pA:
16.7		 2qo6A-1p6pA:
64.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		5 TYR A 215
ILE A  36
ALA A 143
VAL A 142
ASP A 138
 None
T5A  A 501 (-4.5A)
None
None
None
 1.25A 2qo6A-1p75A:
undetectable		 2qo6A-1p75A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		5 TYR A 478
LEU A 482
LEU A 153
THR A 138
HIS A 384
 None
 1.23A 2qo6A-1q15A:
2.2		 2qo6A-1q15A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 TYR A 669
LEU A 637
ALA A 619
ASP A 589
PHE A 456
 None
 1.29A 2qo6A-1q3xA:
undetectable		 2qo6A-1q3xA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A 204
ILE A 234
ALA A 142
THR A 212
HIS A 242
 None
 1.30A 2qo6A-1rzvA:
undetectable		 2qo6A-1rzvA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 304
ILE A 312
LEU A 314
PHE A 434
HIS A 413
 None
 1.16A 2qo6A-1w93A:
undetectable		 2qo6A-1w93A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A 242
LEU A 244
ALA A 259
VAL A 262
THR A 222
 None
 1.18A 2qo6A-2ffhA:
undetectable		 2qo6A-2ffhA:
14.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		5 TYR A  14
LEU A  18
ALA A  31
HIS A  98
ARG A 120
 None
None
OLA  A 130 (-3.3A)
OLA  A 130 ( 4.8A)
None
 0.86A 2qo6A-2ftbA:
19.2		 2qo6A-2ftbA:
69.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		5 TYR A  14
LEU A  18
LEU A  23
ALA A  31
ARG A 120
 None
None
None
OLA  A 130 (-3.3A)
None
 0.86A 2qo6A-2ftbA:
19.2		 2qo6A-2ftbA:
69.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		5 LEU A 260
ILE A 263
VAL A 249
THR A 236
PHE A 194
 None
 1.31A 2qo6A-2fy2A:
undetectable		 2qo6A-2fy2A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		5 LEU A 223
ILE A 213
LEU A 216
ALA A 106
THR A 363
 None
 1.19A 2qo6A-2i3oA:
2.1		 2qo6A-2i3oA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jvz FAR UPSTREAM
ELEMENT-BINDING
PROTEIN 2

(Homo sapiens) 		PF00013
(KH_1) 		5 LEU A  51
ILE A   8
LEU A  37
VAL A  33
THR A  23
 None
 1.29A 2qo6A-2jvzA:
undetectable		 2qo6A-2jvzA:
24.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		6 TYR A  14
ILE A  21
LEU A  23
THR A  73
HIS A  99
ARG A 121
 CHO  A 200 ( 3.8A)
CHO  A 201 ( 4.3A)
CHO  A 200 (-3.9A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.0A)
CHO  A 200 (-2.7A)
 0.75A 2qo6A-2lbaA:
20.3		 2qo6A-2lbaA:
44.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m72 UNCHARACTERIZED
THIOREDOXIN-LIKE
PROTEIN

(Porphyromonas
gingivalis) 		PF00578
(AhpC-TSA) 		5 TYR A  93
LEU A  50
LEU A  47
ALA A  70
VAL A  95
 None
 1.34A 2qo6A-2m72A:
undetectable		 2qo6A-2m72A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa1 PDZ AND LIM DOMAIN
PROTEIN 2

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  52
LEU A  78
ALA A  38
VAL A  32
HIS A  62
 None
 1.28A 2qo6A-2pa1A:
undetectable		 2qo6A-2pa1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3n AGGLUTININ-1 B CHAIN

(Abrus
precatorius) 		PF00652
(Ricin_B_lectin) 		5 LEU B 196
ALA B 159
THR B 147
PHE B 223
MET B 238
 None
 1.20A 2qo6A-2q3nB:
undetectable		 2qo6A-2q3nB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3s PROTEIN AT5G06450

(Arabidopsis
thaliana) 		no annotation 5 TYR A 101
LEU A 129
ILE A 131
LEU A 123
PHE A 111
 None
 1.30A 2qo6A-2q3sA:
undetectable		 2qo6A-2q3sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 217
ILE A 220
LEU A 212
VAL A 182
ASP A 175
 None
 1.18A 2qo6A-2qdeA:
undetectable		 2qo6A-2qdeA:
16.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		12 TYR A  14
LEU A  18
ILE A  21
LEU A  23
ALA A  31
VAL A  34
THR A  72
ASP A  74
PHE A  96
HIS A  98
MET A 118
ARG A 120
 None
CHD  A 130 ( 4.7A)
GOL  A 145 ( 4.8A)
CHD  A 130 ( 4.6A)
CHD  A 130 ( 3.8A)
CHD  A 130 ( 4.8A)
GOL  A 145 (-3.2A)
GOL  A 145 ( 2.8A)
CHD  A 130 ( 4.6A)
IPA  A 140 (-3.7A)
CHD  A 130 ( 3.8A)
CHD  A 130 (-3.4A)
 0.08A 2qo6A-2qo4A:
27.1		 2qo6A-2qo4A:
99.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyo O-METHYLTRANSFERASE

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 ILE A 292
ALA A 254
THR A 207
ASP A 199
PHE A 346
 None
None
SAH  A 601 (-4.0A)
SAH  A 601 ( 4.6A)
None
 1.24A 2qo6A-2qyoA:
undetectable		 2qo6A-2qyoA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1w PDZ AND LIM DOMAIN
PROTEIN 4

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  52
LEU A  78
ALA A  38
VAL A  32
HIS A  62
 None
 1.25A 2qo6A-2v1wA:
undetectable		 2qo6A-2v1wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vil VILLIN 14T

(Gallus gallus) 		PF00626
(Gelsolin) 		5 ILE A  18
LEU A  48
ALA A  92
VAL A  91
THR A  15
 None
 1.25A 2qo6A-2vilA:
undetectable		 2qo6A-2vilA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ILE A 421
LEU A 420
ALA A 165
VAL A 153
HIS A 472
 None
None
None
None
MGD  A1765 (-4.7A)
 1.33A 2qo6A-2vpwA:
undetectable		 2qo6A-2vpwA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 TYR X 426
ILE X 344
LEU X 433
THR X 327
PHE X 345
 None
 1.33A 2qo6A-2y9eX:
undetectable		 2qo6A-2y9eX:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 186
ILE A 177
LEU A 176
VAL A 222
PHE A  39
 None
 1.29A 2qo6A-2yfkA:
undetectable		 2qo6A-2yfkA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 LEU A 275
ILE A 295
ALA A 104
PHE A 154
HIS A 155
 None
 1.06A 2qo6A-3ak5A:
undetectable		 2qo6A-3ak5A:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 419
ILE A 444
VAL A 316
THR A 308
ASP A 305
 None
 1.31A 2qo6A-3au9A:
undetectable		 2qo6A-3au9A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU A  74
ILE A  20
VAL A  59
THR A  85
ARG A  62
 None
 1.28A 2qo6A-3bjlA:
undetectable		 2qo6A-3bjlA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh1 TRNA-SPECIFIC
ADENOSINE DEAMINASE
2

(Homo sapiens) 		PF14437
(MafB19-deam) 		5 LEU A 100
ILE A 119
ALA A  72
VAL A  44
PHE A 152
 None
 1.29A 2qo6A-3dh1A:
undetectable		 2qo6A-3dh1A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 292
ILE A 303
LEU A 304
ALA A 153
ARG A 274
 None
 1.32A 2qo6A-3dtyA:
0.7		 2qo6A-3dtyA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN

(Trypanosoma
brucei) 		PF00255
(GSHPx) 		5 TYR A  28
ILE A  40
LEU A  38
HIS A 116
MET A 105
 None
 1.32A 2qo6A-3dwvA:
undetectable		 2qo6A-3dwvA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0u GLUTATHIONE
PEROXIDASE

(Trypanosoma
cruzi) 		PF00255
(GSHPx) 		5 TYR A  29
ILE A  41
LEU A  39
HIS A 117
MET A 106
 None
 1.34A 2qo6A-3e0uA:
undetectable		 2qo6A-3e0uA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1i CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL

(Gallus gallus) 		PF00355
(Rieske)
PF02921
(UCR_TM) 		5 TYR E 185
ILE E  76
LEU E  78
VAL E 127
PHE E  89
 None
 1.28A 2qo6A-3h1iE:
undetectable		 2qo6A-3h1iE:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 LEU A 841
ILE A 278
ALA A 839
PHE A 291
ARG A1128
 None
 1.12A 2qo6A-3ikmA:
undetectable		 2qo6A-3ikmA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)

(Rattus
norvegicus) 		PF07686
(V-set) 		5 LEU B 180
ILE B 169
VAL B 218
HIS B 160
ARG B 138
 None
 1.30A 2qo6A-3iy7B:
undetectable		 2qo6A-3iy7B:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP0

(Parechovirus B) 		PF00073
(Rhv) 		5 TYR B 196
ALA B 203
VAL B 133
THR B 110
ASP B 208
 None
 1.30A 2qo6A-3jb4B:
undetectable		 2qo6A-3jb4B:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 193
ALA A 213
VAL A 304
PHE A 233
HIS A 234
 None
None
None
None
CU  A 404 (-3.1A)
 1.03A 2qo6A-3kw8A:
undetectable		 2qo6A-3kw8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxi GTP-BINDING PROTEIN
(HFLX)

(Sulfolobus
solfataricus) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		5 LEU A  89
ILE A  93
LEU A  90
VAL A   8
THR A 188
 None
None
None
None
GDP  A 500 (-4.7A)
 1.07A 2qo6A-3kxiA:
undetectable		 2qo6A-3kxiA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 LEU A 227
ILE A 403
LEU A 222
PHE A 393
ARG A 446
 None
 1.11A 2qo6A-3m1cA:
undetectable		 2qo6A-3m1cA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		5 ILE A 468
LEU A 467
ALA A 583
VAL A 585
PHE A 477
 None
 1.22A 2qo6A-3mc2A:
undetectable		 2qo6A-3mc2A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A  77
ILE A  58
LEU A  80
VAL A  97
PHE A  31
 None
 1.31A 2qo6A-3njpA:
undetectable		 2qo6A-3njpA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oid ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH]

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		5 LEU A 161
LEU A 117
ALA A 181
VAL A 182
THR A  10
 None
 1.08A 2qo6A-3oidA:
undetectable		 2qo6A-3oidA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		5 ILE A 102
ALA A  81
VAL A   3
THR A  77
PHE A  31
 None
 1.22A 2qo6A-3r4vA:
undetectable		 2qo6A-3r4vA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H

(Staphylococcus
aureus) 		PF05031
(NEAT) 		5 LEU A 196
ILE A 198
LEU A 217
VAL A 137
PHE A 159
 None
 1.34A 2qo6A-3s48A:
undetectable		 2qo6A-3s48A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbb SMALL LACCASE,
OXIDOREDUCTASE

(Streptomyces
viridosporus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 188
ALA A 208
VAL A 299
PHE A 228
HIS A 229
 None
None
None
None
CU  A   7 ( 3.2A)
 1.05A 2qo6A-3tbbA:
undetectable		 2qo6A-3tbbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		5 LEU A 304
ILE A 308
LEU A 305
VAL A  25
PHE A 314
 None
 1.09A 2qo6A-3td9A:
undetectable		 2qo6A-3td9A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trp CALSEQUESTRIN-1

(Oryctolagus
cuniculus) 		PF01216
(Calsequestrin) 		5 LEU A  58
ILE A  57
ALA A  34
VAL A  97
THR A 114
 None
 1.33A 2qo6A-3trpA:
undetectable		 2qo6A-3trpA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 TYR A 467
LEU A 431
ILE A 434
THR A 127
ASP A 116
 None
 1.20A 2qo6A-3u95A:
undetectable		 2qo6A-3u95A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		5 LEU A  10
ILE A 340
LEU A  54
THR A 389
HIS A 384
 None
 1.34A 2qo6A-3v7pA:
undetectable		 2qo6A-3v7pA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7w URIDYLATE KINASE

(Helicobacter
pylori) 		PF00696
(AA_kinase) 		5 LEU A  94
ILE A  97
LEU A  99
VAL A  12
HIS A  34
 None
 1.21A 2qo6A-4a7wA:
undetectable		 2qo6A-4a7wA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF04166
(PdxA) 		5 LEU A 305
ILE A 307
ALA A 303
VAL A 347
MET A 220
 None
 1.21A 2qo6A-4atyA:
undetectable		 2qo6A-4atyA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 LEU A 154
ILE A 110
LEU A 112
ALA A 157
VAL A 161
 None
 1.20A 2qo6A-4axnA:
undetectable		 2qo6A-4axnA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cz1 KYNURENINE
FORMAMIDASE

(Bacillus
anthracis) 		PF04199
(Cyclase) 		5 LEU A 142
ILE A 143
ALA A 189
VAL A 202
HIS A 161
 None
None
None
None
ZN  A 401 (-3.4A)
 1.21A 2qo6A-4cz1A:
undetectable		 2qo6A-4cz1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 TYR A 735
LEU A 731
ILE A 769
ALA A1137
ARG A 761
 None
 1.32A 2qo6A-4fwtA:
undetectable		 2qo6A-4fwtA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL

(Mus musculus) 		PF00398
(RrnaAD) 		5 LEU A  43
ILE A  47
LEU A  38
ALA A 216
HIS A 208
 None
 1.25A 2qo6A-4gc5A:
undetectable		 2qo6A-4gc5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 193
ALA A 213
VAL A 304
PHE A 233
HIS A 234
 None
None
None
None
CU  A 404 (-3.1A)
 1.06A 2qo6A-4gybA:
undetectable		 2qo6A-4gybA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4k UNCHARACTERIZED
PROTEIN SGCJ

(Streptomyces
globisporus) 		PF14534
(DUF4440) 		5 LEU A  21
ILE A  25
ALA A 120
VAL A 121
PHE A  37
 None
 1.25A 2qo6A-4i4kA:
undetectable		 2qo6A-4i4kA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		5 LEU A 262
ALA A  29
THR A 279
PHE A  50
ARG A 272
 None
 1.26A 2qo6A-4mifA:
undetectable		 2qo6A-4mifA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF13614
(AAA_31) 		5 LEU A 183
ILE A 172
VAL A  12
THR A 141
PHE A 168
 None
 1.29A 2qo6A-4pfsA:
undetectable		 2qo6A-4pfsA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 TYR A 505
LEU A 509
ALA A 449
VAL A 448
PHE A 519
 None
None
None
HEM  A 602 (-4.2A)
None
 1.18A 2qo6A-4ph9A:
undetectable		 2qo6A-4ph9A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A 106
ILE A  88
LEU A  85
VAL A  31
HIS A  57
 None
None
None
None
3KM  A 900 ( 4.4A)
 1.31A 2qo6A-4r0iA:
undetectable		 2qo6A-4r0iA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes) 		PF04198
(Sugar-bind) 		5 ILE A 310
LEU A 288
ALA A 277
VAL A 276
THR A 303
 None
 1.24A 2qo6A-4r9nA:
undetectable		 2qo6A-4r9nA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 190
ALA A 210
VAL A 301
PHE A 230
HIS A 231
 None
None
None
None
CU  A 406 ( 4.9A)
 1.06A 2qo6A-4w1tA:
undetectable		 2qo6A-4w1tA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE

(Haemophilus
influenzae) 		PF00106
(adh_short) 		5 ILE A  86
ALA A  56
VAL A  55
THR A  71
PHE A 151
 None
None
None
NAD  A 301 (-4.8A)
None
 1.27A 2qo6A-4wuvA:
undetectable		 2qo6A-4wuvA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 LEU A  26
ILE A 336
ALA A 362
THR A 404
MET A 291
 None
 1.19A 2qo6A-4wxbA:
undetectable		 2qo6A-4wxbA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9

(Drosophila
melanogaster) 		PF07679
(I-set) 		5 TYR A  80
LEU A  61
VAL A  75
ASP A  48
ARG A  40
 None
 0.92A 2qo6A-4x9fA:
undetectable		 2qo6A-4x9fA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N)
PF12796
(Ank_2) 		5 LEU A 365
ILE A 361
LEU A 360
ALA A 312
PHE A 396
 None
 1.13A 2qo6A-4xd0A:
undetectable		 2qo6A-4xd0A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 TYR A 121
LEU A 235
ILE A 195
ALA A 147
HIS A 160
 None
None
None
None
ZN  A 401 ( 3.2A)
 1.29A 2qo6A-4xixA:
undetectable		 2qo6A-4xixA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 419
ILE A 444
VAL A 316
THR A 308
ASP A 305
 None
 1.27A 2qo6A-4y67A:
undetectable		 2qo6A-4y67A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		5 LEU A 132
ILE A 136
LEU A 128
VAL A 196
PHE A 141
 None
 1.24A 2qo6A-4zweA:
undetectable		 2qo6A-4zweA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF01398
(JAB)
PF13012
(MitMem_reg)
PF01398
(JAB) 		5 LEU H 214
ILE H 211
ALA F 120
VAL F 117
ASP H  42
 None
 1.17A 2qo6A-5a5tH:
undetectable		 2qo6A-5a5tH:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 LEU A 304
ILE A 312
LEU A 314
PHE A 434
HIS A 413
 None
 1.08A 2qo6A-5cslA:
3.0		 2qo6A-5cslA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1q PERIPLASMIC
DIPEPTIDE TRANSPORT
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		5 TYR A  91
LEU A 167
ILE A 152
LEU A 151
PHE A 122
 None
 1.17A 2qo6A-5f1qA:
undetectable		 2qo6A-5f1qA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9m E3 UBIQUITIN-PROTEIN
LIGASE SIAH2

(Homo sapiens) 		PF03145
(Sina) 		5 TYR A 263
LEU A 265
ILE A 315
LEU A 297
PHE A 205
 None
 1.29A 2qo6A-5h9mA:
undetectable		 2qo6A-5h9mA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvf CARBOXYPEPTIDASE B2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 LEU A 373
ILE A  80
LEU A  79
ASP A  75
MET A 215
 None
 1.15A 2qo6A-5hvfA:
undetectable		 2qo6A-5hvfA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME

(Brucella
melitensis) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 332
ILE A 329
ALA A 195
VAL A 196
ASP A 155
 None
 1.15A 2qo6A-5ijgA:
undetectable		 2qo6A-5ijgA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 720
ILE A 705
THR A 684
ASP A 685
HIS A 815
 None
 1.29A 2qo6A-5lstA:
undetectable		 2qo6A-5lstA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 LEU A 135
ILE A 132
LEU A 131
ASP A 189
PHE A 145
 None
 1.27A 2qo6A-5mifA:
undetectable		 2qo6A-5mifA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkm TWO-DOMAIN LACCASE

(Streptomyces
griseoflavus) 		no annotation 5 ILE A 194
ALA A 214
VAL A 305
PHE A 234
HIS A 235
 None
 1.06A 2qo6A-5mkmA:
undetectable		 2qo6A-5mkmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 5 ILE A   4
LEU A 233
ALA A  35
VAL A  46
THR A 246
 None
 1.20A 2qo6A-5nitA:
undetectable		 2qo6A-5nitA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 TYR A 603
THR A 594
ASP A 593
HIS A 660
MET A 665
 None
None
9FQ  A 911 (-3.5A)
None
None
 1.31A 2qo6A-5o0sA:
5.3		 2qo6A-5o0sA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		5 ILE A 296
ALA A 207
THR A 286
PHE A 304
HIS A 306
 None
 1.24A 2qo6A-5uc7A:
undetectable		 2qo6A-5uc7A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		5 TYR A 113
LEU A  63
ALA A 102
PHE A 169
HIS A 165
 None
None
None
None
IPA  A 304 (-3.7A)
 1.33A 2qo6A-5volA:
undetectable		 2qo6A-5volA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 426
ILE A 430
LEU A 411
VAL A 391
THR A 395
 None
 1.31A 2qo6A-5vywA:
undetectable		 2qo6A-5vywA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*

(unidentified) 		no annotation 5 ILE A 176
LEU A 158
ALA A  91
VAL A  93
THR A 112
 None
None
None
CL  A 302 (-4.6A)
None
 1.28A 2qo6A-5wl7A:
1.9		 2qo6A-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 5 TYR B 288
LEU B   5
ILE B   4
LEU B 300
VAL B 285
 None
 1.16A 2qo6A-6emkB:
undetectable		 2qo6A-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6er3 BNR/ASP-BOX REPEAT
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 5 LEU A 129
ALA A 131
VAL A 103
PHE A  72
HIS A  73
 None
 1.32A 2qo6A-6er3A:
undetectable		 2qo6A-6er3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft1 FLAVODOXIN

(Bacillus cereus) 		no annotation 5 LEU A  81
ILE A  79
LEU A  47
ALA A  86
VAL A 117
 None
 1.18A 2qo6A-6ft1A:
undetectable		 2qo6A-6ft1A:
undetectable