SIMILAR PATTERNS OF AMINO ACIDS FOR 2QO5_A_CHDA131_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1p TYROSINE PHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01451
(LMWPc) 		5 ILE A  12
THR A  48
LEU A 101
PHE A  84
HIS A  83
 None
 1.16A 2qo5A-1d1pA:
undetectable		 2qo5A-1d1pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1p TYROSINE PHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01451
(LMWPc) 		5 ILE A 130
ILE A  26
LYS A  28
CYH A  65
THR A  61
 None
 1.12A 2qo5A-1d1pA:
undetectable		 2qo5A-1d1pA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 ILE A 249
ILE A 267
ILE A  22
THR A 257
LEU A 281
 None
 1.19A 2qo5A-1d6sA:
0.0		 2qo5A-1d6sA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 ILE A 314
THR A 311
LEU A 409
HIS A 367
LEU A 364
 None
 1.03A 2qo5A-1e4oA:
0.0		 2qo5A-1e4oA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		5 ILE A  74
ILE A 148
ILE A  58
THR A  85
LEU A  83
 None
 1.05A 2qo5A-1fztA:
0.0		 2qo5A-1fztA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5b SERINE/THREONINE
PROTEIN PHOSPHATASE

(Escherichia
virus Lambda) 		PF00149
(Metallophos) 		5 ILE A 214
LEU A  28
VAL A  47
PHE A  69
LEU A  43
 None
 1.21A 2qo5A-1g5bA:
0.0		 2qo5A-1g5bA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		5 ILE A 205
ILE A  97
THR A 118
PHE A  93
LEU A  86
 None
 1.16A 2qo5A-1g60A:
undetectable		 2qo5A-1g60A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus;
Equus caballus) 		PF00079
(Serpin)
PF00079
(Serpin) 		5 ILE A  50
ILE A 263
LEU A 260
VAL A 239
LEU B 385
 None
 1.09A 2qo5A-1hleA:
0.0		 2qo5A-1hleA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9w 3-DEHYDROQUINATE
DEHYDRATASE AROD

(Salmonella
enterica) 		PF01487
(DHquinase_I) 		5 ILE A  27
THR A  58
LEU A 100
PHE A  79
LEU A 109
 None
 1.06A 2qo5A-1l9wA:
undetectable		 2qo5A-1l9wA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ILE B 167
ILE B 183
THR B 182
LEU B 257
VAL B 223
 None
 1.06A 2qo5A-1skyB:
0.0		 2qo5A-1skyB:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 ILE A  51
THR A  74
CYH A 117
VAL A 115
PHE A  16
 None
None
CRZ  A 501 ( 3.8A)
None
CRZ  A 501 (-4.5A)
 1.21A 2qo5A-1towA:
20.1		 2qo5A-1towA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ILE A  51
ILE A  62
LEU A  57
CYH A 116
HIS A 123
 None
 1.18A 2qo5A-1v0bA:
undetectable		 2qo5A-1v0bA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		5 ILE A 152
ILE A  61
THR A 134
LEU A  45
PHE A 150
 None
 1.09A 2qo5A-1vblA:
undetectable		 2qo5A-1vblA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhx PUTATIVE HOLLIDAY
JUNCTION RESOLVASE

(Bacillus
subtilis) 		PF03652
(RuvX) 		5 ILE A  54
THR A  86
LEU A  42
VAL A  15
PHE A  79
 None
 1.08A 2qo5A-1vhxA:
undetectable		 2qo5A-1vhxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		5 ILE A 346
THR A 343
LEU A 444
HIS A 399
LEU A 396
 None
 1.02A 2qo5A-1ygpA:
undetectable		 2qo5A-1ygpA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A 411
ILE A 226
LEU A 426
CYH A 367
PHE A 216
 None
 1.18A 2qo5A-2bmaA:
undetectable		 2qo5A-2bmaA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 ILE A 459
ILE A 352
ILE A 413
VAL A 383
LEU A 434
 None
 1.13A 2qo5A-2d5lA:
undetectable		 2qo5A-2d5lA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddz 190AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF04017
(DUF366) 		5 ILE A 104
ILE A 122
VAL A 145
THR A 142
LEU A 154
 None
 1.17A 2qo5A-2ddzA:
undetectable		 2qo5A-2ddzA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		5 ILE A  83
THR A  75
LEU A 124
VAL A 133
THR A 145
 None
 1.06A 2qo5A-2e28A:
undetectable		 2qo5A-2e28A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		5 ILE A  94
ILE A  15
LEU A  41
VAL A  22
THR A  88
 None
 1.12A 2qo5A-2fmbA:
undetectable		 2qo5A-2fmbA:
23.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		6 ILE A  70
CYH A  80
VAL A  82
PHE A  96
HIS A  98
LEU A 111
 None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
None
 0.64A 2qo5A-2ftbA:
22.0		 2qo5A-2ftbA:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		6 ILE A  70
THR A  71
CYH A  80
VAL A  82
PHE A  96
HIS A  98
 None
None
None
None
OLA  A 130 ( 4.2A)
OLA  A 130 ( 4.8A)
 1.11A 2qo5A-2ftbA:
22.0		 2qo5A-2ftbA:
68.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		5 ILE A 168
ILE A  36
ILE A  74
LEU A 106
CYH A  99
 None
 1.08A 2qo5A-2gd2A:
undetectable		 2qo5A-2gd2A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		5 ILE A 119
ILE A 112
LEU A  57
CYH A  48
PHE A 192
 None
 1.14A 2qo5A-2i3oA:
undetectable		 2qo5A-2i3oA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF07313
(DUF1460) 		5 ILE A 162
ILE A 283
THR A 285
LEU A 287
HIS A 158
 None
 1.19A 2qo5A-2im9A:
undetectable		 2qo5A-2im9A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ILE A 573
ILE A 777
LEU A 780
VAL A 378
LEU A 522
 None
 0.95A 2qo5A-2iukA:
undetectable		 2qo5A-2iukA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdk ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR-LIKE
PROTEIN 2

(Homo sapiens) 		PF14598
(PAS_11) 		5 ILE A 340
ILE A 414
LEU A 348
CYH A 353
PHE A 386
 None
 1.14A 2qo5A-2kdkA:
undetectable		 2qo5A-2kdkA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		5 ILE A 145
ILE A 134
THR A 443
PHE A 197
HIS A 444
 None
 1.16A 2qo5A-2n0sA:
undetectable		 2qo5A-2n0sA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		5 ILE A 147
ILE A  56
THR A 129
LEU A  45
PHE A 145
 None
 1.05A 2qo5A-2o04A:
undetectable		 2qo5A-2o04A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 ILE A  82
ILE A   9
LEU A  35
THR A  47
LEU A  72
 None
 1.06A 2qo5A-2o4cA:
undetectable		 2qo5A-2o4cA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 ILE A  82
ILE A  30
LEU A  35
HIS A  71
LEU A  72
 None
 1.13A 2qo5A-2o4cA:
undetectable		 2qo5A-2o4cA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		5 ILE A  69
ILE A  82
THR A  49
LEU A  85
THR A  99
 None
 1.17A 2qo5A-2p4zA:
undetectable		 2qo5A-2p4zA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		6 ILE A  21
ILE A  49
ILE A  70
THR A  72
VAL A  82
LEU A 111
 GOL  A 145 ( 4.8A)
IPA  A 141 (-3.9A)
IPA  A 141 ( 4.5A)
GOL  A 145 (-3.2A)
None
CHD  A 130 ( 4.9A)
 0.81A 2qo5A-2qo4A:
22.3		 2qo5A-2qo4A:
98.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		6 ILE A  21
ILE A  49
THR A  72
VAL A  82
HIS A  98
LEU A 111
 GOL  A 145 ( 4.8A)
IPA  A 141 (-3.9A)
GOL  A 145 (-3.2A)
None
IPA  A 140 (-3.7A)
CHD  A 130 ( 4.9A)
 0.97A 2qo5A-2qo4A:
22.3		 2qo5A-2qo4A:
98.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5v PCZA361.1

(Amycolatopsis
orientalis) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		5 ILE A 317
ILE A 335
ILE A 216
VAL A 203
HIS A 161
 None
HHH  A4114 (-4.3A)
None
None
CO  A4113 ( 3.3A)
 1.04A 2qo5A-2r5vA:
undetectable		 2qo5A-2r5vA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0u WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00168
(C2) 		5 ILE A  25
ILE A 128
LEU A 130
VAL A  63
PHE A  38
 None
 1.21A 2qo5A-2z0uA:
undetectable		 2qo5A-2z0uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE

(Methanocaldococcus
jannaschii) 		PF03587
(EMG1) 		5 ILE A  57
ILE A  80
THR A  82
LYS A  86
LEU A  88
 None
 0.99A 2qo5A-3bbhA:
undetectable		 2qo5A-3bbhA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgy POLYNUCLEOTIDE
5'-TRIPHOSPHATASE

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 ILE A  12
ILE A  23
ILE A 137
VAL A  40
PHE A 232
 None
 1.14A 2qo5A-3bgyA:
1.6		 2qo5A-3bgyA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvq NOTI RESTRICTION
ENDONUCLEASE

(Nocardia
otitidiscaviarum) 		PF12183
(NotI) 		5 ILE A 330
ILE A 148
VAL A 180
THR A 257
PHE A 246
 None
 1.13A 2qo5A-3bvqA:
undetectable		 2qo5A-3bvqA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
PHOSPHOTRANSFERASE
SUBUNIT DHAM

(Lactococcus
lactis) 		PF03610
(EIIA-man) 		5 ILE C 112
ILE C  53
ILE C  87
THR C  86
VAL C   8
 None
 1.14A 2qo5A-3cr3C:
undetectable		 2qo5A-3cr3C:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh0 SAM DEPENDENT
METHYLTRANSFERASE

(Aquifex
aeolicus) 		PF13847
(Methyltransf_31) 		5 ILE A 167
ILE A  68
ILE A 110
LEU A 139
VAL A 132
 None
 0.99A 2qo5A-3dh0A:
undetectable		 2qo5A-3dh0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei) 		PF02540
(NAD_synthase) 		5 ILE A  56
ILE A 166
THR A 168
LEU A  50
LEU A 203
 None
 1.17A 2qo5A-3dpiA:
undetectable		 2qo5A-3dpiA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqy TOLUENE
1,2-DIOXYGENASE
SYSTEM FERREDOXIN
SUBUNIT

(Pseudomonas
putida) 		PF00355
(Rieske) 		5 ILE A  58
ILE A  89
THR A  72
VAL A  26
LEU A  54
 CSO  A  69 ( 4.7A)
None
CSO  A  69 ( 3.8A)
None
None
 1.16A 2qo5A-3dqyA:
undetectable		 2qo5A-3dqyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etl DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Methanococcus
maripaludis) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 ILE A 209
ILE A  95
LEU A  91
PHE A 286
LEU A 288
 None
 1.16A 2qo5A-3etlA:
undetectable		 2qo5A-3etlA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etl DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Methanococcus
maripaludis) 		PF08423
(Rad51)
PF14520
(HHH_5) 		5 ILE A 209
ILE A  95
THR A  82
LEU A  91
PHE A 286
 None
 1.01A 2qo5A-3etlA:
undetectable		 2qo5A-3etlA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		5 ILE X 165
ILE X 121
LEU X 118
THR X 101
PHE X 149
 None
 1.21A 2qo5A-3ewbX:
undetectable		 2qo5A-3ewbX:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		5 ILE A 255
ILE A 285
ILE A 276
VAL A 319
LEU A 261
 None
 1.15A 2qo5A-3if2A:
undetectable		 2qo5A-3if2A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		5 ILE A 228
ILE A 306
LEU A 235
THR A 288
LEU A 254
 None
 1.21A 2qo5A-3ifqA:
undetectable		 2qo5A-3ifqA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrr INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 3

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		5 ILE A  13
ILE A 122
LEU A 124
VAL A 183
LEU A 223
 None
 1.20A 2qo5A-3jrrA:
undetectable		 2qo5A-3jrrA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF) 		5 ILE C  83
ILE C 225
ILE C 151
LEU C 129
VAL C  70
 None
 1.19A 2qo5A-3kwvC:
undetectable		 2qo5A-3kwvC:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4e ALPHA-HEMOLYSIN

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		5 ILE A 245
THR A 243
LEU A  90
THR A 230
LEU A  52
 None
 1.16A 2qo5A-3m4eA:
1.1		 2qo5A-3m4eA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc1 PREDICTED
PHOSPHATASE, HAD
FAMILY

(Clostridium
acetobutylicum) 		PF13419
(HAD_2) 		5 ILE A  89
ILE A  20
ILE A 117
LEU A 118
THR A 107
 None
GOL  A 303 ( 4.6A)
None
None
None
 1.04A 2qo5A-3mc1A:
undetectable		 2qo5A-3mc1A:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN

(Bos taurus) 		PF10409
(PTEN_C2) 		5 ILE A 199
ILE A  71
THR A  64
VAL A 105
HIS A 160
 None
 0.91A 2qo5A-3n0aA:
undetectable		 2qo5A-3n0aA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 INTERFERON ALPHA-5
IFN-ALPHA/BETA
BINDING PROTEIN C12R

(Mus musculus;
Ectromelia
virus) 		PF00143
(Interferon)
PF00047
(ig)
PF13895
(Ig_2) 		5 ILE A  67
ILE B 272
LEU A  60
VAL A 156
LEU A  18
 None
 1.21A 2qo5A-3oq3A:
undetectable		 2qo5A-3oq3A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0g OBP14

(Apis mellifera) 		PF01395
(PBP_GOBP) 		5 ILE A  68
ILE A  32
LEU A   6
PHE A  54
LEU A  51
 None
 1.19A 2qo5A-3s0gA:
undetectable		 2qo5A-3s0gA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slr UNCHARACTERIZED
PROTEIN BF1531

(Bacteroides
fragilis) 		no annotation 5 ILE A 226
LEU A 367
THR A 232
PHE A 261
LEU A 298
 None
 1.20A 2qo5A-3slrA:
undetectable		 2qo5A-3slrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ILE A  22
LEU A  48
VAL A  15
HIS A  69
LEU A  71
 None
 0.93A 2qo5A-3sm9A:
undetectable		 2qo5A-3sm9A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		5 ILE A 141
ILE A 126
LEU A 119
PHE A 131
HIS A 130
 None
 1.15A 2qo5A-3tqsA:
undetectable		 2qo5A-3tqsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE

(Acetobacter
aceti) 		PF02515
(CoA_transf_3) 		5 ILE A 331
LEU A 274
CYH A 289
VAL A 352
HIS A 346
 None
 1.18A 2qo5A-3ubmA:
undetectable		 2qo5A-3ubmA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ud2 ANKYRIN-1

(Homo sapiens) 		no annotation 5 ILE C1188
THR C1192
LEU C1172
CYH C1174
VAL C1176
 None
 1.20A 2qo5A-3ud2C:
undetectable		 2qo5A-3ud2C:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 367
ILE A 300
ILE A 350
LEU A 372
THR A 336
 None
 1.16A 2qo5A-3vwaA:
undetectable		 2qo5A-3vwaA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		no annotation 5 ILE 2  24
ILE 2  46
LEU 2  45
CYH 2  49
VAL 2  55
 None
 1.20A 2qo5A-4e2i2:
undetectable		 2qo5A-4e2i2:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fda 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		5 ILE A  63
ILE A   8
THR A  10
LEU A 117
CYH A 155
 None
 1.16A 2qo5A-4fdaA:
undetectable		 2qo5A-4fdaA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		5 ILE A 115
THR A 117
LEU A 103
CYH A 105
THR A  71
 None
 1.06A 2qo5A-4gq1A:
2.8		 2qo5A-4gq1A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4b PYLD

(Methanosarcina
barkeri) 		no annotation 5 ILE A  99
ILE A  31
ILE A  70
THR A  71
LEU A  67
 None
 1.14A 2qo5A-4j4bA:
undetectable		 2qo5A-4j4bA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpb CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF01584
(CheW) 		5 ILE A 585
ILE A 558
ILE A 566
THR A 565
VAL A 626
 None
 1.17A 2qo5A-4jpbA:
undetectable		 2qo5A-4jpbA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 ILE A 191
VAL A 262
THR A 272
PHE A 153
LEU A 189
 None
 0.95A 2qo5A-4kpoA:
undetectable		 2qo5A-4kpoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9a ACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 167
LEU A 150
CYH A 217
THR A 190
LEU A 165
 None
 1.19A 2qo5A-4m9aA:
undetectable		 2qo5A-4m9aA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		5 ILE A 114
ILE A 177
THR A 238
PHE A 116
HIS A 240
 None
 1.14A 2qo5A-4oanA:
undetectable		 2qo5A-4oanA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		5 ILE A 312
ILE A 172
ILE A 167
THR A 233
HIS A 235
 None
 1.10A 2qo5A-4p47A:
undetectable		 2qo5A-4p47A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		5 ILE A 312
ILE A 172
THR A 233
PHE A 112
HIS A 235
 None
 1.01A 2qo5A-4p47A:
undetectable		 2qo5A-4p47A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		no annotation 5 ILE A 381
ILE A 259
LEU A 335
THR A 368
PHE A 304
 None
 1.07A 2qo5A-4qanA:
undetectable		 2qo5A-4qanA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqb HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Staphylococcus
aureus) 		PF00156
(Pribosyltran) 		5 ILE A 130
ILE A 175
ILE A  24
LEU A  28
CYH A  25
 None
 1.14A 2qo5A-4rqbA:
undetectable		 2qo5A-4rqbA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqx SORTASE

(Streptococcus
mutans) 		PF04203
(Sortase) 		5 ILE A 244
ILE A 103
LEU A 105
THR A 204
HIS A 140
 None
 1.07A 2qo5A-4tqxA:
undetectable		 2qo5A-4tqxA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		5 ILE A 278
ILE A 186
THR A 168
LEU A 325
LEU A 287
 None
 1.08A 2qo5A-4u4eA:
undetectable		 2qo5A-4u4eA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		5 ILE A 255
LEU A  42
VAL A  70
THR A  46
LEU A 124
 None
 1.12A 2qo5A-4wjmA:
undetectable		 2qo5A-4wjmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2

(Homo sapiens) 		no annotation 5 ILE B 229
ILE B 141
THR B 140
LEU B 222
PHE B  17
 None
 0.93A 2qo5A-4x0rB:
undetectable		 2qo5A-4x0rB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE

(Mycoplasma
pneumoniae) 		PF01266
(DAO) 		5 ILE A 261
ILE A  92
LEU A 106
THR A  52
HIS A  51
 None
None
None
None
FAD  A 401 (-4.0A)
 1.05A 2qo5A-4x9nA:
undetectable		 2qo5A-4x9nA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		5 ILE A 427
ILE A 400
ILE A 466
VAL A 509
LEU A 501
 None
 1.20A 2qo5A-4yooA:
undetectable		 2qo5A-4yooA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		5 ILE A 572
ILE A 493
ILE A 595
LEU A 580
LEU A 600
 None
 1.19A 2qo5A-5axhA:
undetectable		 2qo5A-5axhA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		5 ILE A 519
THR A 521
LEU A 529
VAL A 613
LEU A 594
 None
 1.08A 2qo5A-5b48A:
undetectable		 2qo5A-5b48A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqk ICP27

(Human
alphaherpesvirus
1) 		PF05459
(Herpes_UL69) 		5 ILE A 422
ILE A 425
LEU A 472
CYH A 468
LEU A 387
 None
 1.20A 2qo5A-5bqkA:
undetectable		 2qo5A-5bqkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bym SUPPRESSOR PROTEIN
MPT5

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 ILE A 292
ILE A 318
CYH A 348
VAL A 344
PHE A 359
 None
 1.09A 2qo5A-5bymA:
undetectable		 2qo5A-5bymA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c17 MERB2

(Bacillus
megaterium) 		PF03243
(MerB) 		5 ILE A 130
ILE A 104
THR A 106
VAL A 152
HIS A 169
 None
DTV  A 303 ( 3.0A)
None
None
GOL  A 302 (-3.0A)
 1.12A 2qo5A-5c17A:
undetectable		 2qo5A-5c17A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 ILE B 223
ILE B 118
ILE B 233
VAL B 144
HIS B 150
 None
 1.11A 2qo5A-5do7B:
undetectable		 2qo5A-5do7B:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 ILE A 391
ILE A  84
LEU A 418
VAL A 345
PHE A  67
 None
 1.19A 2qo5A-5g2vA:
0.0		 2qo5A-5g2vA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guh PIWI

(Bombyx mori) 		PF02170
(PAZ)
PF02171
(Piwi) 		5 ILE A 308
THR A 306
LEU A 457
THR A 826
PHE A 787
 None
 1.21A 2qo5A-5guhA:
undetectable		 2qo5A-5guhA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis;
Bacillus
subtilis) 		PF02463
(SMC_N)
PF02463
(SMC_N) 		5 ILE B1105
ILE A 141
LEU B1116
CYH B1114
VAL B1111
 None
 1.17A 2qo5A-5h67B:
undetectable		 2qo5A-5h67B:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 ILE A 308
ILE A 335
LEU A 337
CYH A 372
THR A 368
 None
 1.16A 2qo5A-5ikpA:
undetectable		 2qo5A-5ikpA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE

(Plasmodium
falciparum) 		PF07992
(Pyr_redox_2) 		5 ILE A 344
ILE A 317
LEU A 333
CYH A 355
LEU A 144
 None
None
None
MG  A 602 (-3.2A)
None
 1.18A 2qo5A-5jwbA:
undetectable		 2qo5A-5jwbA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		5 ILE A 416
ILE A 113
THR A 109
LEU A 611
VAL A 189
 ZPE  A 703 (-4.8A)
ZPE  A 703 ( 4.6A)
ZPE  A 703 ( 4.4A)
ZPE  A 703 ( 4.9A)
None
 1.20A 2qo5A-5lc8A:
undetectable		 2qo5A-5lc8A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 ILE A 390
THR A 387
LEU A 573
HIS A 443
LEU A 440
 None
 0.96A 2qo5A-5lrbA:
undetectable		 2qo5A-5lrbA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5d METHYLTRANSFERASE

(Streptomyces
regensis) 		PF01596
(Methyltransf_3) 		5 ILE A 145
THR A 216
LEU A 193
VAL A 220
PHE A 149
 None
 1.16A 2qo5A-5n5dA:
undetectable		 2qo5A-5n5dA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 ILE A  33
ILE A 332
THR A 331
LEU A 326
VAL A 322
 None
 1.21A 2qo5A-5o0sA:
2.6		 2qo5A-5o0sA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE

(Leishmania
donovani) 		PF00579
(tRNA-synt_1b) 		5 ILE A 133
ILE A 142
THR A 138
CYH A 145
VAL A 188
 None
 1.00A 2qo5A-5usfA:
undetectable		 2qo5A-5usfA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5f TAIL TUBE PROTEIN
GP19

(Enterobacteria
phage T4 sensu
lato) 		PF06841
(Phage_T4_gp19) 		5 ILE A  91
ILE A 129
ILE A  25
LEU A  28
VAL A  71
 None
 1.19A 2qo5A-5w5fA:
undetectable		 2qo5A-5w5fA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		5 ILE A  31
ILE A 135
ILE A 142
LEU A 144
LEU A   7
 None
 1.13A 2qo5A-5xnsA:
undetectable		 2qo5A-5xnsA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E

(Pseudomonas sp.
AIU 813) 		no annotation 5 THR A 337
CYH A 331
VAL A  51
THR A 329
LEU A 346
 ORN  A 603 (-3.0A)
FAD  A 601 (-4.6A)
FAD  A 601 (-4.4A)
None
None
 1.15A 2qo5A-5yb7A:
undetectable		 2qo5A-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE

(Elizabethkingia
anophelis) 		no annotation 5 ILE A 135
ILE A 276
ILE A 204
LEU A 202
PHE A 130
 None
None
None
None
EDO  A 604 (-4.6A)
 1.14A 2qo5A-6bzcA:
undetectable		 2qo5A-6bzcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehn CARBOHYDRATE
ESTERASE MZ0003

(unidentified
prokaryotic
organism) 		no annotation 5 ILE A 212
ILE A 316
LEU A 315
CYH A 319
THR A 262
 None
 1.20A 2qo5A-6ehnA:
1.4		 2qo5A-6ehnA:
undetectable