SIMILAR PATTERNS OF AMINO ACIDS FOR 2QO4_A_CHDA130_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a87 COLICIN N

(Escherichia
coli) 		PF01024
(Colicin) 		5 LEU A 350
ILE A 347
VAL A 258
THR A 362
MET A 361
 None
 1.25A 2qo4A-1a87A:
2.4		 2qo4A-1a87A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1del DEOXYNUCLEOSIDE
MONOPHOSPHATE KINASE

(Escherichia
virus T4) 		no annotation 5 LEU A  40
ILE A  36
VAL A  79
HIS A 206
ARG A 133
 None
 1.28A 2qo4A-1delA:
0.0		 2qo4A-1delA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm1 MYOGLOBIN

(Aplysia
limacina) 		PF00042
(Globin) 		5 LEU A 133
ILE A 137
ALA A  10
PHE A  91
MET A  84
 None
None
None
HEM  A 148 (-4.6A)
None
 1.08A 2qo4A-1dm1A:
undetectable		 2qo4A-1dm1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001

(Methanothermobacter
thermautotrophicus) 		PF02598
(Methyltrn_RNA_3) 		5 LEU A  61
ILE A  57
ALA A  35
VAL A  40
THR A 246
 None
 1.32A 2qo4A-1k3rA:
undetectable		 2qo4A-1k3rA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		5 LEU A  69
ILE A  97
ALA A  57
THR A 116
ASP A  64
 None
 1.19A 2qo4A-1ktwA:
undetectable		 2qo4A-1ktwA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		5 LEU A  27
ALA A 224
VAL A 221
THR A 235
HIS A 210
 None
None
None
P6G  A 600 ( 4.8A)
FE2  A 500 ( 3.5A)
 1.32A 2qo4A-1lkdA:
0.0		 2qo4A-1lkdA:
16.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		5 TYR A  14
LEU A  18
ALA A  31
HIS A  98
ARG A 120
 None
 1.02A 2qo4A-1p6pA:
16.7		 2qo4A-1p6pA:
64.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		5 TYR A 215
ILE A  36
ALA A 143
VAL A 142
ASP A 138
 None
T5A  A 501 (-4.5A)
None
None
None
 1.25A 2qo4A-1p75A:
undetectable		 2qo4A-1p75A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 TYR A 669
LEU A 637
ALA A 619
ASP A 589
PHE A 456
 None
 1.30A 2qo4A-1q3xA:
0.0		 2qo4A-1q3xA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A 204
ILE A 234
ALA A 142
THR A 212
HIS A 242
 None
 1.30A 2qo4A-1rzvA:
0.0		 2qo4A-1rzvA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjn ZN-DEPENDENT
HYDROLASE OF
METALLO-BETA-LACTAMA
SE SUPERFAMILY
TM0207

(Thermotoga
maritima) 		PF13483
(Lactamase_B_3) 		5 LEU A 130
ILE A 157
VAL A 121
ASP A 150
PHE A 177
 None
 1.38A 2qo4A-1vjnA:
undetectable		 2qo4A-1vjnA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdu TRAS1 ORF2P

(Bombyx mori) 		PF14529
(Exo_endo_phos_2) 		5 TYR A 125
ALA A 158
VAL A 212
THR A 180
MET A 178
 None
 1.43A 2qo4A-1wduA:
undetectable		 2qo4A-1wduA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf9 NPL4 FAMILY PROTEIN

(Arabidopsis
thaliana) 		PF11543
(UN_NPL4) 		5 LEU A  33
ILE A  28
VAL A  12
THR A   8
MET A   9
 None
 1.35A 2qo4A-1wf9A:
undetectable		 2qo4A-1wf9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 LEU A 193
ILE A 195
ALA A 191
VAL A 304
PHE A  78
 None
 1.30A 2qo4A-1zliA:
undetectable		 2qo4A-1zliA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		5 ILE A  53
VAL A 257
MET A 241
ASP A 261
MET A  17
 None
None
EDO  A 404 (-4.4A)
None
None
 1.40A 2qo4A-2ashA:
undetectable		 2qo4A-2ashA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 TYR A  32
LEU A  43
ILE A  60
VAL A 340
HIS A   7
 None
 1.35A 2qo4A-2b3xA:
undetectable		 2qo4A-2b3xA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 CO-CHAPERONE PROTEIN
SBA1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU X  49
ILE X  47
VAL X  84
THR X  80
MET X  81
 None
 1.32A 2qo4A-2cg9X:
undetectable		 2qo4A-2cg9X:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 TYR A 220
ALA A  37
VAL A  45
THR A   6
PHE A 327
 None
 1.42A 2qo4A-2dy3A:
undetectable		 2qo4A-2dy3A:
16.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftb FATTY ACID-BINDING
PROTEIN 2, LIVER

(Ambystoma
mexicanum) 		PF14651
(Lipocalin_7) 		5 TYR A  14
LEU A  18
ALA A  31
HIS A  98
ARG A 120
 None
None
OLA  A 130 (-3.3A)
OLA  A 130 ( 4.8A)
None
 0.88A 2qo4A-2ftbA:
21.5		 2qo4A-2ftbA:
69.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		5 LEU A 260
ILE A 263
VAL A 249
THR A 236
PHE A 194
 None
 1.31A 2qo4A-2fy2A:
undetectable		 2qo4A-2fy2A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		5 LEU A 133
ALA A 149
THR A 139
MET A 140
PHE A  93
 None
 1.37A 2qo4A-2i9kA:
undetectable		 2qo4A-2i9kA:
17.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		5 ILE A  21
THR A  73
MET A  74
HIS A  99
ARG A 121
 CHO  A 201 ( 4.3A)
CHO  A 201 (-2.8A)
CHO  A 200 (-2.6A)
CHO  A 201 (-3.0A)
CHO  A 200 (-2.7A)
 1.19A 2qo4A-2lbaA:
20.3		 2qo4A-2lbaA:
45.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lba BABP PROTEIN

(Gallus gallus) 		PF14651
(Lipocalin_7) 		5 TYR A  14
ILE A  21
THR A  73
HIS A  99
ARG A 121
 CHO  A 200 ( 3.8A)
CHO  A 201 ( 4.3A)
CHO  A 201 (-2.8A)
CHO  A 201 (-3.0A)
CHO  A 200 (-2.7A)
 0.74A 2qo4A-2lbaA:
20.3		 2qo4A-2lbaA:
45.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osa N-CHIMAERIN

(Homo sapiens) 		PF00620
(RhoGAP) 		5 TYR A 266
ALA A 342
VAL A 315
MET A 287
HIS A 277
 None
 1.00A 2qo4A-2osaA:
undetectable		 2qo4A-2osaA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3n AGGLUTININ-1 B CHAIN

(Abrus
precatorius) 		PF00652
(Ricin_B_lectin) 		5 LEU B 196
ALA B 159
THR B 147
PHE B 223
MET B 238
 None
 1.21A 2qo4A-2q3nB:
undetectable		 2qo4A-2q3nB:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		7 LEU A  23
ILE A  21
ALA A  31
VAL A  34
THR A  72
MET A  73
PHE A  96
 CHD  A 130 ( 4.6A)
GOL  A 145 ( 4.8A)
CHD  A 130 ( 3.8A)
CHD  A 130 ( 4.8A)
GOL  A 145 (-3.2A)
None
CHD  A 130 ( 4.6A)
 1.41A 2qo4A-2qo4A:
27.7		 2qo4A-2qo4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		12 TYR A  14
LEU A  18
ILE A  21
ALA A  31
VAL A  34
THR A  72
MET A  73
ASP A  74
PHE A  96
HIS A  98
MET A 118
ARG A 120
 None
CHD  A 130 ( 4.7A)
GOL  A 145 ( 4.8A)
CHD  A 130 ( 3.8A)
CHD  A 130 ( 4.8A)
GOL  A 145 (-3.2A)
None
GOL  A 145 ( 2.8A)
CHD  A 130 ( 4.6A)
IPA  A 140 (-3.7A)
CHD  A 130 ( 3.8A)
CHD  A 130 (-3.4A)
 0.00A 2qo4A-2qo4A:
27.7		 2qo4A-2qo4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyo O-METHYLTRANSFERASE

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 ILE A 292
ALA A 254
THR A 207
ASP A 199
PHE A 346
 None
None
SAH  A 601 (-4.0A)
SAH  A 601 ( 4.6A)
None
 1.24A 2qo4A-2qyoA:
undetectable		 2qo4A-2qyoA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v25 MAJOR CELL-BINDING
FACTOR

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		5 LEU A  14
ILE A   8
ALA A  43
VAL A  42
THR A 202
 None
 1.42A 2qo4A-2v25A:
undetectable		 2qo4A-2v25A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		5 LEU A 121
ILE A 125
VAL A 100
THR A 331
MET A 330
 None
 1.30A 2qo4A-2w7yA:
undetectable		 2qo4A-2w7yA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780

(Pyrococcus
horikoshii) 		PF00571
(CBS) 		5 ALA A  82
VAL A  73
THR A   8
MET A   7
ASP A 111
 None
 1.36A 2qo4A-2yzqA:
undetectable		 2qo4A-2yzqA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 LEU A 275
ILE A 295
ALA A 104
PHE A 154
HIS A 155
 None
 1.06A 2qo4A-3ak5A:
undetectable		 2qo4A-3ak5A:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 419
ILE A 444
VAL A 316
THR A 308
ASP A 305
 None
 1.30A 2qo4A-3au9A:
undetectable		 2qo4A-3au9A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 LEU A 842
ALA A 628
THR A 761
MET A 760
HIS A 617
 None
 1.33A 2qo4A-3b2rA:
undetectable		 2qo4A-3b2rA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU A  74
ILE A  20
VAL A  59
THR A  85
ARG A  62
 None
 1.27A 2qo4A-3bjlA:
undetectable		 2qo4A-3bjlA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145

(Methanococcus
maripaludis) 		PF01968
(Hydantoinase_A) 		5 VAL A 267
THR A 138
MET A 134
ASP A 140
HIS A 176
 None
 1.37A 2qo4A-3c0bA:
undetectable		 2qo4A-3c0bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxl N-CHIMERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 TYR A 266
ALA A 342
VAL A 315
MET A 287
HIS A 277
 None
 1.07A 2qo4A-3cxlA:
undetectable		 2qo4A-3cxlA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh1 TRNA-SPECIFIC
ADENOSINE DEAMINASE
2

(Homo sapiens) 		PF14437
(MafB19-deam) 		5 LEU A 100
ILE A 119
ALA A  72
VAL A  44
PHE A 152
 None
 1.28A 2qo4A-3dh1A:
undetectable		 2qo4A-3dh1A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eul POSSIBLE
NITRATE/NITRITE
RESPONSE
TRANSCRIPTIONAL
REGULATORY PROTEIN
NARL (DNA-BINDING
RESPONSE REGULATOR,
LUXR FAMILY)

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg) 		5 ILE A  96
ALA A  73
VAL A  85
MET A  64
ASP A  68
 None
 1.24A 2qo4A-3eulA:
undetectable		 2qo4A-3eulA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhm UNCHARACTERIZED
PROTEIN ATU1752

(Agrobacterium
fabrum) 		PF00571
(CBS) 		5 ALA A  28
VAL A  19
THR A  79
MET A  78
ASP A  57
 None
None
AMP  A 200 (-3.5A)
None
AMP  A 200 (-2.9A)
 1.39A 2qo4A-3fhmA:
undetectable		 2qo4A-3fhmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		5 LEU A 154
ALA A  92
VAL A  91
THR A 124
MET A 113
 None
 1.23A 2qo4A-3hfqA:
3.2		 2qo4A-3hfqA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 LEU A 841
ILE A 278
ALA A 839
PHE A 291
ARG A1128
 None
 1.13A 2qo4A-3ikmA:
undetectable		 2qo4A-3ikmA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)

(Rattus
norvegicus) 		PF07686
(V-set) 		5 LEU B 180
ILE B 169
VAL B 218
HIS B 160
ARG B 138
 None
 1.28A 2qo4A-3iy7B:
undetectable		 2qo4A-3iy7B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP0

(Parechovirus B) 		PF00073
(Rhv) 		5 TYR B 196
ALA B 203
VAL B 133
THR B 110
ASP B 208
 None
 1.30A 2qo4A-3jb4B:
undetectable		 2qo4A-3jb4B:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 ILE E 256
ALA E 169
VAL E 328
PHE E 222
HIS E 224
 None
 1.42A 2qo4A-3kdsE:
undetectable		 2qo4A-3kdsE:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 193
ALA A 213
VAL A 304
PHE A 233
HIS A 234
 None
None
None
None
CU  A 404 (-3.1A)
 1.06A 2qo4A-3kw8A:
undetectable		 2qo4A-3kw8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116

(Vibrio
parahaemolyticus) 		PF13743
(Thioredoxin_5) 		5 TYR A 104
LEU A 108
ILE A 111
THR A  88
ASP A  10
 PG6  A 209 (-4.1A)
None
None
None
None
 1.43A 2qo4A-3kzqA:
undetectable		 2qo4A-3kzqA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A  52
ALA A 355
VAL A 358
PHE A  62
HIS A  67
 None
 1.38A 2qo4A-3kzuA:
0.2		 2qo4A-3kzuA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n29 CARBOXYNORSPERMIDINE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00278
(Orn_DAP_Arg_deC) 		5 LEU A 328
ILE A 252
VAL A 282
THR A 309
MET A 319
 None
 1.29A 2qo4A-3n29A:
undetectable		 2qo4A-3n29A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohw PHYCOBILISOME LCM
CORE-MEMBRANE LINKER
POLYPEPTIDE

(Synechocystis
sp. PCC 6803) 		no annotation 5 TYR B 792
LEU B 831
ILE B 835
PHE B 808
HIS B 807
 None
 1.39A 2qo4A-3ohwB:
undetectable		 2qo4A-3ohwB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		5 ILE A 102
ALA A  81
VAL A   3
THR A  77
PHE A  31
 None
 1.23A 2qo4A-3r4vA:
undetectable		 2qo4A-3r4vA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbb SMALL LACCASE,
OXIDOREDUCTASE

(Streptomyces
viridosporus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 188
ALA A 208
VAL A 299
PHE A 228
HIS A 229
 None
None
None
None
CU  A   7 ( 3.2A)
 1.07A 2qo4A-3tbbA:
undetectable		 2qo4A-3tbbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trp CALSEQUESTRIN-1

(Oryctolagus
cuniculus) 		PF01216
(Calsequestrin) 		5 LEU A  58
ILE A  57
ALA A  34
VAL A  97
THR A 114
 None
 1.32A 2qo4A-3trpA:
undetectable		 2qo4A-3trpA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 TYR A 467
LEU A 431
ILE A 434
THR A 127
ASP A 116
 None
 1.19A 2qo4A-3u95A:
undetectable		 2qo4A-3u95A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF04166
(PdxA) 		5 LEU A 305
ILE A 307
ALA A 303
VAL A 347
MET A 220
 None
 1.20A 2qo4A-4atyA:
undetectable		 2qo4A-4atyA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cz1 KYNURENINE
FORMAMIDASE

(Bacillus
anthracis) 		PF04199
(Cyclase) 		5 LEU A 142
ILE A 143
ALA A 189
VAL A 202
HIS A 161
 None
None
None
None
ZN  A 401 (-3.4A)
 1.19A 2qo4A-4cz1A:
undetectable		 2qo4A-4cz1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus) 		PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel) 		5 LEU A 209
VAL A 290
THR A 369
ASP A 321
MET A 201
 None
 1.42A 2qo4A-4d2iA:
undetectable		 2qo4A-4d2iA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A 351
ALA A 199
VAL A 198
THR A 244
ASP A 230
 None
None
None
ZN  A 412 (-4.8A)
ZN  A 412 (-2.1A)
 1.41A 2qo4A-4egeA:
undetectable		 2qo4A-4egeA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fry PUTATIVE
SIGNAL-TRANSDUCTION
PROTEIN WITH CBS
DOMAINS

(Burkholderia
ambifaria) 		PF00571
(CBS) 		5 ALA A  31
VAL A  22
THR A  81
MET A  80
ASP A  59
 None
None
AMP  A 202 (-3.6A)
None
AMP  A 202 (-2.6A)
 1.28A 2qo4A-4fryA:
undetectable		 2qo4A-4fryA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuu LEUCINE
AMINOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF04389
(Peptidase_M28) 		5 LEU A  80
ILE A 107
ALA A 161
VAL A 164
HIS A 210
 None
 1.21A 2qo4A-4fuuA:
undetectable		 2qo4A-4fuuA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 TYR A 735
LEU A 731
ILE A 769
ALA A1137
ARG A 761
 None
 1.34A 2qo4A-4fwtA:
undetectable		 2qo4A-4fwtA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 244
ALA A 168
VAL A 167
THR A 252
ASP A 230
 None
 1.40A 2qo4A-4jbhA:
undetectable		 2qo4A-4jbhA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		5 LEU A 101
ILE A 102
ALA A 115
PHE A  44
HIS A  32
 None
 1.41A 2qo4A-4lxiA:
undetectable		 2qo4A-4lxiA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		5 LEU A 262
ALA A  29
THR A 279
PHE A  50
ARG A 272
 None
 1.25A 2qo4A-4mifA:
undetectable		 2qo4A-4mifA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		5 LEU A 262
ALA A  29
VAL A  39
THR A 279
ARG A 272
 None
 1.41A 2qo4A-4mifA:
undetectable		 2qo4A-4mifA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF13614
(AAA_31) 		5 LEU A 183
ILE A 172
VAL A  12
THR A 141
PHE A 168
 None
 1.28A 2qo4A-4pfsA:
undetectable		 2qo4A-4pfsA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 TYR A 505
LEU A 509
ALA A 449
VAL A 448
PHE A 519
 None
None
None
HEM  A 602 (-4.2A)
None
 1.17A 2qo4A-4ph9A:
undetectable		 2qo4A-4ph9A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		5 LEU A 126
ILE A 121
VAL A  57
PHE A 383
HIS A 385
 None
 1.35A 2qo4A-4rnwA:
undetectable		 2qo4A-4rnwA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		5 LEU A 275
ILE A 270
VAL A 206
PHE A 133
HIS A 135
 None
 1.38A 2qo4A-4rnxA:
undetectable		 2qo4A-4rnxA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 LEU A 582
ILE A 579
ALA A 681
VAL A 626
MET A 516
 None
 1.10A 2qo4A-4u33A:
undetectable		 2qo4A-4u33A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ILE A 190
ALA A 210
VAL A 301
PHE A 230
HIS A 231
 None
None
None
None
CU  A 406 ( 4.9A)
 1.08A 2qo4A-4w1tA:
undetectable		 2qo4A-4w1tA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE

(Haemophilus
influenzae) 		PF00106
(adh_short) 		5 ILE A  86
ALA A  56
VAL A  55
THR A  71
PHE A 151
 None
None
None
NAD  A 301 (-4.8A)
None
 1.28A 2qo4A-4wuvA:
undetectable		 2qo4A-4wuvA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 LEU A  26
ILE A 336
ALA A 362
THR A 404
MET A 291
 None
 1.18A 2qo4A-4wxbA:
undetectable		 2qo4A-4wxbA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9f DOWN SYNDROME CELL
ADHESION MOLECULE
ISOFORM 6.9

(Drosophila
melanogaster) 		PF07679
(I-set) 		5 TYR A  80
LEU A  61
VAL A  75
ASP A  48
ARG A  40
 None
 0.93A 2qo4A-4x9fA:
undetectable		 2qo4A-4x9fA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 419
ILE A 444
VAL A 316
THR A 308
ASP A 305
 None
 1.26A 2qo4A-4y67A:
undetectable		 2qo4A-4y67A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		5 LEU A  27
ILE A  22
VAL A 357
PHE A 284
HIS A 286
 None
 1.37A 2qo4A-4yncA:
undetectable		 2qo4A-4yncA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida) 		PF00753
(Lactamase_B) 		5 LEU A 192
ALA A 187
ASP A 254
PHE A 173
HIS A 212
 None
None
None
GSH  A 302 ( 4.9A)
GSH  A 302 ( 4.8A)
 1.40A 2qo4A-4yslA:
undetectable		 2qo4A-4yslA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF01398
(JAB)
PF13012
(MitMem_reg)
PF01398
(JAB) 		5 LEU H 214
ILE H 211
ALA F 120
VAL F 117
ASP H  42
 None
 1.19A 2qo4A-5a5tH:
undetectable		 2qo4A-5a5tH:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE

(Thermus
thermophilus) 		PF00571
(CBS) 		5 ALA A  97
VAL A  88
THR A   8
MET A   7
ASP A 125
 None
 1.15A 2qo4A-5aweA:
undetectable		 2qo4A-5aweA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE

(Thermus
thermophilus) 		PF00571
(CBS) 		5 VAL A  88
THR A   8
MET A   7
ASP A 125
PHE A  32
 None
 1.03A 2qo4A-5aweA:
undetectable		 2qo4A-5aweA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1n MHC CLASS I ANTIGEN
BETA-2-MICROGLOBULIN

(Canis lupus;
Canis lupus) 		PF00129
(MHC_I)
PF07654
(C1-set)
PF07654
(C1-set) 		5 TYR A  85
LEU A  81
ALA A 140
ASP A 116
HIS B  58
 None
 1.36A 2qo4A-5f1nA:
1.7		 2qo4A-5f1nA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 LEU A 855
ALA A 925
THR A 761
HIS A 684
ARG A 630
 None
None
None
None
G1P  A1201 (-3.9A)
 1.31A 2qo4A-5h42A:
1.7		 2qo4A-5h42A:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		5 LEU A  95
ILE A  91
ALA A  70
VAL A  73
THR A  28
 None
 1.38A 2qo4A-5hfjA:
undetectable		 2qo4A-5hfjA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		5 LEU A 438
ILE A 339
ALA A 536
VAL A 533
HIS A 443
 None
None
None
None
MG  A 702 (-3.3A)
 1.40A 2qo4A-5hmqA:
undetectable		 2qo4A-5hmqA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsx PUTATIVE
ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		5 ILE A  93
VAL A  51
THR A 284
ASP A 117
HIS A  64
 EDO  A 409 (-4.6A)
None
None
NA  A 401 (-3.6A)
None
 1.41A 2qo4A-5hsxA:
undetectable		 2qo4A-5hsxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME

(Brucella
melitensis) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 332
ILE A 329
ALA A 195
VAL A 196
ASP A 155
 None
 1.15A 2qo4A-5ijgA:
undetectable		 2qo4A-5ijgA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngd PORTAL PROTEIN

(Thermus virus
P74-26) 		no annotation 5 LEU A 312
ILE A  75
ALA A 218
VAL A 219
PHE A  76
 None
 1.38A 2qo4A-5ngdA:
undetectable		 2qo4A-5ngdA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 TYR A 603
THR A 594
ASP A 593
HIS A 660
MET A 665
 None
None
9FQ  A 911 (-3.5A)
None
None
 1.30A 2qo4A-5o0sA:
undetectable		 2qo4A-5o0sA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 VAL A 127
THR A 184
MET A 183
ASP A 168
MET A 223
 None
ATP  A 601 (-2.8A)
None
ATP  A 601 (-2.3A)
GDP  A 602 (-4.7A)
 0.87A 2qo4A-5tc3A:
undetectable		 2qo4A-5tc3A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		5 ILE A 237
ALA A 374
VAL A 371
MET A 421
ARG A 394
 None
 1.30A 2qo4A-5ti8A:
undetectable		 2qo4A-5ti8A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		5 ILE A 296
ALA A 207
THR A 286
PHE A 304
HIS A 306
 None
 1.24A 2qo4A-5uc7A:
undetectable		 2qo4A-5uc7A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4p NADPH DEHYDROGENASE
3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  27
ILE A  22
VAL A 357
PHE A 284
HIS A 286
 None
 1.30A 2qo4A-5v4pA:
undetectable		 2qo4A-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voh NADH OXIDASE

(Lactobacillus
brevis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 TYR A 199
LEU A 329
ILE A 334
ALA A 163
PHE A 187
 None
 1.42A 2qo4A-5vohA:
undetectable		 2qo4A-5vohA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		5 TYR A 113
LEU A  63
ALA A 102
PHE A 169
HIS A 165
 None
None
None
None
IPA  A 304 (-3.7A)
 1.33A 2qo4A-5volA:
undetectable		 2qo4A-5volA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 5 ILE A  80
ALA A 338
VAL A 209
PHE A  84
HIS A  87
 None
 1.40A 2qo4A-5w6mA:
0.4		 2qo4A-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byf TYROSINE-PROTEIN
PHOSPHATASE SIW14

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 155
ILE A 156
ALA A 198
VAL A 202
PHE A 134
 None
 1.41A 2qo4A-6byfA:
undetectable		 2qo4A-6byfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4) 		no annotation 5 TYR B 358
LEU B 362
ILE B 365
ALA B  76
THR B 244
 None
 1.40A 2qo4A-6c2jB:
undetectable		 2qo4A-6c2jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Acinetobacter
baumannii) 		no annotation 5 LEU A 115
ILE A  38
ALA A 126
VAL A 127
THR A 152
 None
 1.39A 2qo4A-6cauA:
undetectable		 2qo4A-6cauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)

(Escherichia
coli) 		no annotation 5 ILE A  72
VAL A 135
MET A 219
PHE A  82
ARG A 198
 None
 1.24A 2qo4A-6d5iA:
undetectable		 2qo4A-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 5 TYR A 362
LEU A 499
ILE A 495
ALA A 503
THR A 333
 None
 1.41A 2qo4A-6et7A:
undetectable		 2qo4A-6et7A:
undetectable