SIMILAR PATTERNS OF AMINO ACIDS FOR 2QMM_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bx0 PROTEIN
(FERREDOXIN:NADP+
OXIDOREDUCTASE)

(Spinacia
oleracea) 		PF00175
(NAD_binding_1) 		5 LEU A 211
ILE A 174
GLY A 173
GLY A 273
SER A 209
 None
 1.16A 2qmmA-1bx0A:
3.0		 2qmmA-1bx0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.78A 2qmmA-1bxzA:
2.6		 2qmmA-1bxzA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhr DIHYDROPTERIDINE
REDUCTASE

(Rattus
norvegicus) 		PF00106
(adh_short) 		5 LEU A 223
GLY A 132
SER A 222
SER A 220
CYH A 157
 None
 1.16A 2qmmA-1dhrA:
2.5		 2qmmA-1dhrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3r FV ANTIBODY FRAGMENT

(Rattus
norvegicus) 		PF07686
(V-set) 		5 LEU B 192
ILE B 196
GLY B 195
SER B 191
LEU B 184
 None
 1.20A 2qmmA-1f3rB:
undetectable		 2qmmA-1f3rB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0i INOSITOL
MONOPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF00459
(Inositol_P) 		5 ILE A 208
GLY A 111
GLY A 101
LEU A 177
CYH A 180
 None
 1.20A 2qmmA-1g0iA:
undetectable		 2qmmA-1g0iA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 LEU A 137
ILE A  96
GLY A  97
GLY A  98
LEU A  93
 None
None
None
AMI  A1388 ( 3.7A)
None
 1.16A 2qmmA-1hkkA:
undetectable		 2qmmA-1hkkA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A1180
ILE A1175
GLY A1174
GLY A1243
CYH A1203
 None
 0.81A 2qmmA-1jqbA:
2.5		 2qmmA-1jqbA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		5 LEU A 450
ILE A 426
GLY A 454
GLY A 456
SER A 446
 None
 1.17A 2qmmA-1lqtA:
3.8		 2qmmA-1lqtA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 LEU A 380
ILE A 361
GLY A 360
GLY A 316
SER A  56
 None
None
IMP  A 801 (-4.1A)
IMP  A 801 (-3.6A)
None
 1.16A 2qmmA-1lrtA:
undetectable		 2qmmA-1lrtA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 ILE B 303
GLY B 299
GLY B 277
SER B 455
LEU B 256
 None
 1.05A 2qmmA-1m1jB:
undetectable		 2qmmA-1m1jB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		5 LEU A 550
GLY A 557
GLY A 570
SER A 518
LEU A 528
 None
 1.03A 2qmmA-1mz5A:
undetectable		 2qmmA-1mz5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		6 LEU A  72
GLY A 103
GLY A 104
SER A 121
SER A 123
LEU A 127
 None
 1.25A 2qmmA-1ns5A:
8.2		 2qmmA-1ns5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		7 LEU A  72
ILE A 102
GLY A 103
GLY A 107
SER A 121
SER A 123
LEU A 127
 None
 0.57A 2qmmA-1ns5A:
8.2		 2qmmA-1ns5A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6d HYPOTHETICAL UPF0247
PROTEIN TM0844

(Thermotoga
maritima) 		PF02590
(SPOUT_MTase) 		5 ILE A  99
GLY A 100
GLY A 104
SER A 118
SER A 120
 None
 0.69A 2qmmA-1o6dA:
8.4		 2qmmA-1o6dA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 GLU A 214
ILE A 177
GLY A 178
GLY A 179
LEU A 205
 None
 1.15A 2qmmA-1oi7A:
2.2		 2qmmA-1oi7A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		5 LEU A  87
GLY A 113
GLY A 117
SER A 132
LEU A 138
 SAH  A 300 (-4.4A)
SAH  A 300 (-3.2A)
SAH  A 300 (-3.6A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.1A)
 0.77A 2qmmA-1p9pA:
8.3		 2qmmA-1p9pA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 LEU A 133
ILE A 160
GLY A 161
GLY A 156
LEU A 248
 FAD  A 749 ( 4.4A)
FAD  A 749 (-4.5A)
None
None
None
 1.16A 2qmmA-1q1rA:
undetectable		 2qmmA-1q1rA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76

(Thermotoga
maritima) 		PF03641
(Lysine_decarbox) 		6 LEU A  21
ILE A 103
GLY A   8
SER A  19
LEU A  50
CYH A  25
 None
 1.45A 2qmmA-1rcuA:
2.0		 2qmmA-1rcuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlg 50S RIBOSOMAL
PROTEIN L7AE

(Archaeoglobus
fulgidus) 		PF01248
(Ribosomal_L7Ae) 		5 LEU A  19
ILE A  97
GLY A 101
SER A  17
LEU A 110
 None
 1.06A 2qmmA-1rlgA:
undetectable		 2qmmA-1rlgA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rni ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol) 		5 LEU A 118
GLU A 116
ILE A 144
GLY A 143
GLY A 142
 None
 1.17A 2qmmA-1rniA:
undetectable		 2qmmA-1rniA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1saw HYPOTHETICAL PROTEIN
FLJ36880

(Homo sapiens) 		PF01557
(FAA_hydrolase) 		5 LEU A 182
GLY A  79
GLY A  95
SER A 174
CYH A  82
 None
 1.14A 2qmmA-1sawA:
undetectable		 2qmmA-1sawA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		5 LEU A  82
GLU A 140
SER A  86
SER A 139
LEU A 136
 None
 1.18A 2qmmA-1spgA:
undetectable		 2qmmA-1spgA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA

(Bacillus
subtilis) 		PF02590
(SPOUT_MTase) 		6 LEU A  76
ILE A 107
GLY A 108
GLY A 112
SER A 126
SER A 128
 None
 0.65A 2qmmA-1to0A:
7.5		 2qmmA-1to0A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaq CYTOSINE DEAMINASE

(Saccharomyces
cerevisiae) 		PF00383
(dCMP_cyt_deam_1) 		5 LEU A  88
ILE A  33
GLY A  34
GLY A  35
SER A 116
 None
DUC  A 300 (-3.4A)
None
None
None
 1.12A 2qmmA-1uaqA:
undetectable		 2qmmA-1uaqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		5 ILE A 196
GLY A 197
GLY A 198
LEU A  56
CYH A  57
 None
YSA  A3001 (-3.6A)
YSA  A3001 (-3.0A)
None
None
 1.13A 2qmmA-1vbmA:
undetectable		 2qmmA-1vbmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		5 LEU A 116
ILE A  75
GLY A  76
GLY A  77
LEU A  72
 None
 1.14A 2qmmA-1vf8A:
undetectable		 2qmmA-1vf8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh0 HYPOTHETICAL UPF0247
PROTEIN
SAV0024/SA0023

(Staphylococcus
aureus) 		PF02590
(SPOUT_MTase) 		6 LEU A  76
ILE A 107
GLY A 108
GLY A 112
SER A 126
SER A 128
 None
 0.65A 2qmmA-1vh0A:
7.2		 2qmmA-1vh0A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 LEU A 137
ILE A  96
GLY A  97
GLY A  98
LEU A  93
 None
 1.09A 2qmmA-1wb0A:
undetectable		 2qmmA-1wb0A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		6 LEU A  47
ILE A 196
GLY A 197
GLY A 168
SER A  48
LEU A 189
 None
 1.04A 2qmmA-1wl1A:
undetectable		 2qmmA-1wl1A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.98A 2qmmA-1y9aA:
2.1		 2qmmA-1y9aA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zud ADENYLYLTRANSFERASE
THIF

(Escherichia
coli) 		PF00899
(ThiF) 		5 LEU 1 221
GLY 1 155
GLY 1 224
SER 1 231
LEU 1 158
 None
 1.08A 2qmmA-1zud1:
3.3		 2qmmA-1zud1:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 356
ILE A 337
GLY A 336
GLY A 298
SER A  52
 None
None
XMP  A1001 (-3.6A)
XMP  A1001 (-3.5A)
None
 0.95A 2qmmA-2cu0A:
undetectable		 2qmmA-2cu0A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eiz ANTI-LYSOZYME
ANTIBODY FV REGION

(Homo sapiens) 		PF07686
(V-set) 		5 LEU B  20
ILE B 107
GLY B 106
GLY B 104
SER B  79
 None
 1.06A 2qmmA-2eizB:
undetectable		 2qmmA-2eizB:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eno SYNAPTOJANIN-2-BINDI
NG PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  34
GLY A  36
GLY A  37
SER A  74
LEU A  91
 None
 1.10A 2qmmA-2enoA:
undetectable		 2qmmA-2enoA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 342
ILE A 349
GLY A 348
GLY A 190
LEU A  15
 None
 0.88A 2qmmA-2gqdA:
undetectable		 2qmmA-2gqdA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 LEU A  85
GLY A 164
SER A  87
SER A 121
LEU A 144
 None
 1.19A 2qmmA-2ipjA:
undetectable		 2qmmA-2ipjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jky HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 LEU A  66
ILE A  36
GLY A  37
GLY A  38
LEU A  68
 None
None
SO4  A 301 ( 4.1A)
SO4  A 301 (-3.2A)
None
 1.20A 2qmmA-2jkyA:
undetectable		 2qmmA-2jkyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 GLU A 208
ILE A 212
GLY A 125
GLY A 124
LEU A 204
 None
 1.11A 2qmmA-2oi6A:
undetectable		 2qmmA-2oi6A:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qmm UPF0217 PROTEIN
AF_1056

(Archaeoglobus
fulgidus) 		PF04013
(Methyltrn_RNA_2) 		9 LEU A 221
GLU A 223
ILE A 241
GLY A 242
GLY A 246
SER A 264
SER A 266
LEU A 270
CYH A 275
 SAM  A 301 (-4.3A)
SAM  A 301 (-3.5A)
SAM  A 301 ( 4.8A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.2A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.1A)
 0.02A 2qmmA-2qmmA:
41.2		 2qmmA-2qmmA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A1286
ILE A1284
GLY A1303
GLY A1334
SER A1275
 None
 1.12A 2qmmA-2vdcA:
undetectable		 2qmmA-2vdcA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A 671
GLY A 670
GLY A 669
SER A 680
LEU A 714
 None
 0.94A 2qmmA-2wtbA:
undetectable		 2qmmA-2wtbA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		5 LEU A 321
GLU A  21
ILE A 294
GLY A 318
LEU A 287
 None
 1.07A 2qmmA-2wu0A:
undetectable		 2qmmA-2wu0A:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococcus
jannaschii) 		PF04013
(Methyltrn_RNA_2) 		8 LEU X 136
ILE X 155
GLY X 156
GLY X 160
SER X 178
SER X 180
LEU X 184
CYH X 189
 SAM  X 501 (-4.3A)
SAM  X 501 ( 4.8A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 4.2A)
SAM  X 501 ( 3.7A)
SAM  X 501 (-4.2A)
SAM  X 501 (-4.3A)
SAM  X 501 (-3.3A)
 0.44A 2qmmA-3ai9X:
31.2		 2qmmA-3ai9X:
43.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7o ENDO-1,4-BETA-XYLANA
SE

(Bacillus
subtilis) 		PF03422
(CBM_6)
PF04616
(Glyco_hydro_43) 		5 LEU A 276
GLU A 338
ILE A 257
GLY A 258
GLY A 273
 None
 1.18A 2qmmA-3c7oA:
undetectable		 2qmmA-3c7oA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN

(Escherichia
coli) 		PF00005
(ABC_tran)
PF09383
(NIL) 		5 LEU C   4
GLU C  68
ILE C   7
GLY C  60
LEU C  69
 None
 1.02A 2qmmA-3dhwC:
undetectable		 2qmmA-3dhwC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 LEU A 332
ILE A 341
GLY A 340
GLY A 339
SER A 331
 None
 1.16A 2qmmA-3e77A:
undetectable		 2qmmA-3e77A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		5 LEU A 255
ILE A 259
GLY A 220
SER A   8
LEU A 217
 None
 1.18A 2qmmA-3e7fA:
undetectable		 2qmmA-3e7fA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euw MYO-INOSITOL
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 248
GLU A 240
ILE A 141
GLY A 246
LEU A 147
 None
 1.16A 2qmmA-3euwA:
3.4		 2qmmA-3euwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpc NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.82A 2qmmA-3fpcA:
undetectable		 2qmmA-3fpcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.83A 2qmmA-3fplA:
2.7		 2qmmA-3fplA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.82A 2qmmA-3fsrA:
2.4		 2qmmA-3fsrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH

(Escherichia
coli) 		PF00294
(PfkB) 		5 ILE A  93
GLY A  65
GLY A  70
SER A 145
LEU A 121
 None
 1.17A 2qmmA-3in1A:
2.4		 2qmmA-3in1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR

(Homo sapiens) 		PF13621
(Cupin_8) 		5 LEU A 146
ILE A 189
GLY A 190
SER A  91
LEU A 186
 None
 1.15A 2qmmA-3kcxA:
undetectable		 2qmmA-3kcxA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kly PUTATIVE FORMATE
TRANSPORTER 1

(Vibrio cholerae) 		PF01226
(Form_Nir_trans) 		5 ILE A 262
GLY A 260
GLY A 167
SER A  92
LEU A  94
 None
 1.08A 2qmmA-3klyA:
undetectable		 2qmmA-3klyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpm PUTATIVE
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF05175
(MTS) 		5 LEU A  66
ILE A  62
GLY A  61
SER A  44
LEU A  40
 None
 1.18A 2qmmA-3lpmA:
undetectable		 2qmmA-3lpmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2t PROBABLE
DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA) 		5 LEU A   8
ILE A  11
GLY A  10
GLY A  74
SER A  22
 None
None
NAD  A 358 (-3.2A)
NAD  A 358 (-3.7A)
None
 1.13A 2qmmA-3m2tA:
undetectable		 2qmmA-3m2tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC

(Pisum sativum) 		PF00175
(NAD_binding_1) 		5 LEU A 205
ILE A 168
GLY A 167
GLY A 267
SER A 203
 None
 1.11A 2qmmA-3mhpA:
3.9		 2qmmA-3mhpA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		5 ILE K 412
GLY K 406
GLY K 353
SER K 132
SER K 138
 None
 1.19A 2qmmA-3mvdK:
undetectable		 2qmmA-3mvdK:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		5 LEU A 195
GLY A 218
GLY A 223
SER A 237
LEU A 247
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
None
SAM  A 770 (-4.5A)
 0.77A 2qmmA-3nk7A:
10.7		 2qmmA-3nk7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onq REGULATOR OF
POLYKETIDE SYNTHASE
EXPRESSION

(Bifidobacterium
adolescentis) 		PF13556
(HTH_30) 		5 LEU A 123
ILE A  56
GLY A  57
GLY A  58
CYH A 108
 None
None
None
None
GOL  A 269 (-2.6A)
 0.98A 2qmmA-3onqA:
undetectable		 2qmmA-3onqA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvv CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Mycobacterium
tuberculosis) 		PF08299
(Bac_DnaA_C) 		5 ILE A 462
GLY A 463
GLY A 467
SER A 412
CYH A 451
 None
 0.94A 2qmmA-3pvvA:
undetectable		 2qmmA-3pvvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvv CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Mycobacterium
tuberculosis) 		PF08299
(Bac_DnaA_C) 		5 LEU A 457
ILE A 462
GLY A 463
SER A 412
CYH A 451
 None
 1.08A 2qmmA-3pvvA:
undetectable		 2qmmA-3pvvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		5 LEU A 138
GLU A 140
ILE A 171
GLY A 170
LEU A 143
 None
 1.19A 2qmmA-3rotA:
2.0		 2qmmA-3rotA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 106
GLY A 120
SER A 102
SER A  98
LEU A  96
 None
 0.99A 2qmmA-3s6lA:
undetectable		 2qmmA-3s6lA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 363
ILE A 344
GLY A 343
GLY A 305
SER A  48
 None
None
XMP  A 500 (-3.8A)
XMP  A 500 (-3.5A)
None
 1.09A 2qmmA-3tsdA:
undetectable		 2qmmA-3tsdA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vo2 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00175
(NAD_binding_1) 		5 LEU A 211
ILE A 174
GLY A 173
GLY A 273
SER A 209
 None
 1.09A 2qmmA-3vo2A:
undetectable		 2qmmA-3vo2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5v FERREDOXIN

(Zea mays) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A 211
ILE A 174
GLY A 173
GLY A 273
SER A 209
 None
 1.15A 2qmmA-3w5vA:
undetectable		 2qmmA-3w5vA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ab4 XENOBIOTIC REDUCTASE
B

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		5 LEU A  99
ILE A 172
GLY A 174
SER A  58
SER A  60
 None
 1.13A 2qmmA-4ab4A:
undetectable		 2qmmA-4ab4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		5 LEU A 120
GLU A 228
GLY A 118
GLY A 346
LEU A 238
 None
 1.20A 2qmmA-4be3A:
undetectable		 2qmmA-4be3A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A  62
ILE A 355
GLY A 356
GLY A 119
SER A 124
 None
 0.98A 2qmmA-4dd5A:
undetectable		 2qmmA-4dd5A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fpw CALU16

(Micromonospora
echinospora) 		PF08327
(AHSA1) 		5 LEU A 122
ILE A  24
GLY A 126
GLY A 128
SER A 118
 None
 1.04A 2qmmA-4fpwA:
undetectable		 2qmmA-4fpwA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Escherichia
coli) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A 254
ILE A 118
GLY A 119
SER A 259
LEU A 286
 None
 1.15A 2qmmA-4i34A:
undetectable		 2qmmA-4i34A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		5 LEU A   4
GLU A 232
ILE A   8
GLY A 280
SER A   3
 None
 1.11A 2qmmA-4jo0A:
undetectable		 2qmmA-4jo0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A3255
ILE A3296
GLY A3065
GLY A3064
LEU A3148
 None
 1.15A 2qmmA-4kc5A:
undetectable		 2qmmA-4kc5A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 340
ILE A 347
GLY A 346
GLY A 188
LEU A  13
 None
 0.98A 2qmmA-4ls5A:
undetectable		 2qmmA-4ls5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		5 LEU A 503
GLU A 570
GLY A 528
GLY A 568
LEU A 571
 None
 1.19A 2qmmA-4maeA:
undetectable		 2qmmA-4maeA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3h KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		6 LEU A 115
ILE A  65
GLY A 145
SER A 116
SER A  15
LEU A  25
 None
 1.22A 2qmmA-4p3hA:
undetectable		 2qmmA-4p3hA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF01946
(Thi4) 		5 LEU A 102
GLU A  93
ILE A 100
GLY A  99
LEU A  94
 None
 1.16A 2qmmA-4y4mA:
undetectable		 2qmmA-4y4mA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypw TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Haemophilus
influenzae) 		PF01746
(tRNA_m1G_MT) 		5 LEU A  87
GLY A 113
GLY A 117
SER A 132
LEU A 138
 None
4FD  A 301 (-4.7A)
4FD  A 301 (-3.6A)
4FD  A 301 (-3.2A)
4FD  A 301 (-3.9A)
 0.80A 2qmmA-4ypwA:
8.8		 2qmmA-4ypwA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA

(Thermotoga
maritima) 		PF00633
(HHH)
PF02457
(DisA_N)
PF10635
(DisA-linker) 		5 LEU A 329
GLU A 327
ILE A 335
GLY A 336
SER A 325
 None
 0.80A 2qmmA-4yxmA:
undetectable		 2qmmA-4yxmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		5 ILE A 293
GLY A 294
GLY A 296
SER A  27
LEU A  23
 None
 1.00A 2qmmA-4z9nA:
undetectable		 2qmmA-4z9nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		5 ILE A 293
GLY A 294
SER A  35
SER A  27
LEU A  23
 None
 1.07A 2qmmA-4z9nA:
undetectable		 2qmmA-4z9nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5caj UPF0246 PROTEIN YAAA

(Escherichia
coli) 		PF03883
(H2O2_YaaD) 		5 LEU A 135
ILE A 133
GLY A 132
SER A  31
LEU A 114
 None
 1.03A 2qmmA-5cajA:
undetectable		 2qmmA-5cajA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA

(Pseudomonas
protegens) 		no annotation 5 LEU E  24
ILE E 343
GLY E 341
SER E  22
SER E  18
 None
 1.14A 2qmmA-5dbjE:
undetectable		 2qmmA-5dbjE:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A 366
ILE A 365
GLY A 352
GLY A 500
SER A 521
 None
 1.12A 2qmmA-5h3kA:
undetectable		 2qmmA-5h3kA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilg PHOTORECEPTOR
DEHYDROGENASE,
ISOFORM C

(Drosophila
melanogaster) 		PF00106
(adh_short) 		6 LEU A 118
ILE A 175
GLY A 122
GLY A 127
SER A 116
SER A 113
 None
 1.37A 2qmmA-5ilgA:
2.9		 2qmmA-5ilgA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixd TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 ILE A 323
GLY A 322
GLY A 319
SER A 407
SER A 404
 None
 0.92A 2qmmA-5ixdA:
undetectable		 2qmmA-5ixdA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN

(Stenotrophomonas
maltophilia) 		PF12849
(PBP_like_2) 		5 LEU A  11
GLY A 207
GLY A 206
SER A  61
SER A  63
 PO4  A 401 (-4.1A)
None
None
None
None
 1.15A 2qmmA-5j1dA:
undetectable		 2qmmA-5j1dA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		5 GLU T 233
ILE T  13
GLY T 304
GLY T 286
LEU T 234
 None
 1.18A 2qmmA-5k0yT:
undetectable		 2qmmA-5k0yT:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2v CHITIN-BINDING
PROTEIN

(Listeria
monocytogenes) 		PF03067
(LPMO_10) 		5 LEU A  13
ILE A  18
GLY A  17
SER A   9
SER A   5
 None
None
P33  A 202 ( 3.7A)
None
None
 1.09A 2qmmA-5l2vA:
undetectable		 2qmmA-5l2vA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 5 LEU A 712
GLU A 688
GLY A 680
GLY A 682
CYH A 716
 None
CA  A 810 (-2.1A)
None
None
None
 1.20A 2qmmA-5m11A:
undetectable		 2qmmA-5m11A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nii THIOREDOXIN
REDUCTASE

(Desulfovibrio
vulgaris) 		no annotation 5 LEU A 210
GLU A 202
ILE A 198
GLY A 215
SER A 208
 None
 1.14A 2qmmA-5niiA:
2.4		 2qmmA-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		6 LEU A 140
ILE A 339
GLY A 336
GLY A 333
SER A 138
SER A 233
 None
 1.34A 2qmmA-5o1mA:
undetectable		 2qmmA-5o1mA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 5 ILE A 195
GLY A 196
GLY A 200
SER A 218
LEU A 224
 None
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
None
SAM  A 501 (-4.5A)
 0.88A 2qmmA-5o96A:
11.3		 2qmmA-5o96A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubz ANTI-HIV1 GP120 MAB
1E12 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 5 LEU H  20
ILE H 107
GLY H 106
GLY H 104
SER H  79
 None
 1.19A 2qmmA-5ubzH:
undetectable		 2qmmA-5ubzH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		5 LEU A 363
ILE A 344
GLY A 343
GLY A 305
SER A  48
 None
None
IMP  A 500 (-3.6A)
IMP  A 500 (-3.4A)
None
 0.95A 2qmmA-5upyA:
undetectable		 2qmmA-5upyA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		5 LEU A 363
ILE A 344
GLY A 343
GLY A 305
SER A  48
 None
None
IMP  A 501 (-3.9A)
IMP  A 501 ( 3.2A)
None
 0.97A 2qmmA-5uuwA:
undetectable		 2qmmA-5uuwA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A  92
GLY A 118
GLY A 122
SER A 137
LEU A 143
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.2A)
 0.79A 2qmmA-5wyrA:
7.3		 2qmmA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwl PAL

(Bacillus
thuringiensis) 		no annotation 5 LEU A 253
ILE A 250
GLY A 210
SER A 258
LEU A 204
 None
UDP  A 402 (-4.0A)
EDO  A 404 ( 4.8A)
None
None
 1.12A 2qmmA-6bwlA:
undetectable		 2qmmA-6bwlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3

(Homo sapiens) 		no annotation 5 LEU A  85
GLY A 164
SER A  87
SER A 121
LEU A 144
 None
 1.14A 2qmmA-6f2uA:
undetectable		 2qmmA-6f2uA:
undetectable