SIMILAR PATTERNS OF AMINO ACIDS FOR 2QM9_B_TDZB202_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o8v FATTY ACID BINDING
PROTEIN HOMOLOG

(Echinococcus
granulosus) 		PF00061
(Lipocalin) 		4 MET A  20
PRO A  38
ASP A  77
ARG A 107
 PLM  A1136 (-3.5A)
None
PLM  A1136 (-3.8A)
PLM  A1136 (-3.9A)
 0.48A 2qm9B-1o8vA:
24.2		 2qm9B-1o8vA:
36.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 OLA  A 200 (-4.6A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.2A)
 0.79A 2qm9B-1pmpA:
25.1		 2qm9B-1pmpA:
63.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.5A)
CRZ  A 501 (-4.0A)
None
 0.32A 2qm9B-1towA:
26.2		 2qm9B-1towA:
91.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 EIC  A 601 ( 4.1A)
EIC  A 601 (-4.6A)
EIC  A 601 (-3.6A)
None
 0.13A 2qm9B-2q9sA:
27.3		 2qm9B-2q9sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 MET A  21
PRO A  39
ASP A  77
ARG A 107
 PLM  A 901 (-3.7A)
SO4  A 903 ( 4.8A)
PLM  A 901 (-4.0A)
PLM  A 901 (-3.7A)
 0.41A 2qm9B-3nr3A:
25.6		 2qm9B-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp6 SODIUM-CALCIUM
EXCHANGER

(Doryteuthis
pealeii) 		PF00061
(Lipocalin) 		4 MET A  21
PRO A  39
ASP A  77
ARG A 106
 PAM  A 133 ( 3.9A)
PAM  A 133 (-4.4A)
PAM  A 133 (-4.3A)
None
 0.39A 2qm9B-3pp6A:
23.8		 2qm9B-3pp6A:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 2AN  A 201 ( 3.9A)
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.9A)
None
 0.51A 2qm9B-3wbgA:
25.5		 2qm9B-3wbgA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		4 MET A  21
PRO A  39
ASP A  77
ARG A 107
 EDO  A1134 (-4.5A)
None
EDO  A1134 (-3.7A)
None
 0.88A 2qm9B-4a60A:
24.4		 2qm9B-4a60A:
55.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		4 MET A  23
PRO A  41
ASP A  79
ARG A 109
 A9M  A1136 (-3.7A)
A9M  A1136 ( 4.7A)
A9M  A1136 (-4.0A)
None
 0.52A 2qm9B-4azpA:
25.0		 2qm9B-4azpA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 75D  A 201 (-3.6A)
75D  A 201 (-4.4A)
75D  A 201 (-4.1A)
75D  A 201 ( 4.6A)
 0.26A 2qm9B-4nnsA:
26.6		 2qm9B-4nnsA:
81.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af7 ACYL-COA
DEHYDROGENASE

(Advenella
mimigardefordensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 MET A  50
PRO A  37
ASP A 117
ARG A  84
 None
None
None
FAD  A 410 (-3.7A)
 1.40A 2qm9B-5af7A:
undetectable		 2qm9B-5af7A:
17.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b29 FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 PLM  A 200 ( 4.0A)
PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.3A)
None
 0.54A 2qm9B-5b29A:
25.3		 2qm9B-5b29A:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvq FATTY ACID-BINDING
PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		4 MET A  21
PRO A  39
ASP A  77
ARG A 107
 None
 0.47A 2qm9B-5bvqA:
24.2		 2qm9B-5bvqA:
73.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		4 MET A  23
PRO A  41
ASP A  79
ARG A 110
 PAM  A 201 ( 3.8A)
PAM  A 201 ( 4.8A)
PAM  A 201 (-4.0A)
PAM  A 201 ( 4.6A)
 0.25A 2qm9B-5bvtA:
25.2		 2qm9B-5bvtA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Homo sapiens) 		PF00061
(Lipocalin) 		4 MET A  23
PRO A  41
ASP A  79
ARG A 109
 65X  A 203 ( 3.9A)
65X  A 203 (-4.4A)
65X  A 203 ( 4.2A)
65X  A 203 (-4.0A)
 0.33A 2qm9B-5hz5A:
24.6		 2qm9B-5hz5A:
47.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjv DUAL SPECIFICITY
PROTEIN PHOSPHATASE
13 ISOFORM A

(Homo sapiens) 		no annotation 4 MET A 145
PRO A 167
ASP A 179
ARG A 160
 None
 1.13A 2qm9B-5xjvA:
undetectable		 2qm9B-5xjvA:
18.42