SIMILAR PATTERNS OF AMINO ACIDS FOR 2QM9_A_TDZA201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ftp MUSCLE FATTY ACID
BINDING PROTEIN

(Schistocerca
gregaria) 		PF00061
(Lipocalin) 		4 TYR A  20
MET A  21
PRO A  39
ILE A 106
 None
 0.73A 2qm9A-1ftpA:
19.9		 2qm9A-1ftpA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		4 TYR A  19
MET A  20
PRO A  38
ILE A 104
 None
OLA  A 200 (-4.6A)
None
None
 0.64A 2qm9A-1pmpA:
24.5		 2qm9A-1pmpA:
63.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
MET A  20
PRO A  38
ILE A 104
 None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-4.5A)
CRZ  A 501 ( 4.8A)
 0.27A 2qm9A-1towA:
25.6		 2qm9A-1towA:
91.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		4 TYR A 293
MET A 294
PRO A  94
ILE A 266
 None
 1.25A 2qm9A-2nq2A:
undetectable		 2qm9A-2nq2A:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 TYR A  19
MET A  20
PRO A  38
ILE A 104
 None
EIC  A 601 ( 4.1A)
EIC  A 601 (-4.6A)
EIC  A 601 ( 4.5A)
 0.24A 2qm9A-2q9sA:
26.6		 2qm9A-2q9sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  20
MET A  21
PRO A  39
ILE A 105
 None
PLM  A 901 (-3.7A)
SO4  A 903 ( 4.8A)
PLM  A 901 ( 4.5A)
 0.54A 2qm9A-3nr3A:
25.3		 2qm9A-3nr3A:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  20
MET A  21
PRO A  39
ILE A 105
 None
EDO  A1134 (-4.5A)
None
None
 0.48A 2qm9A-4a60A:
24.3		 2qm9A-4a60A:
55.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		4 TYR A  22
MET A  23
PRO A  41
ILE A 107
 None
 0.78A 2qm9A-4aznA:
22.8		 2qm9A-4aznA:
47.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		4 TYR A  22
MET A  23
PRO A  41
ILE A 107
 None
A9M  A1136 (-3.7A)
A9M  A1136 ( 4.7A)
A9M  A1136 (-4.4A)
 0.63A 2qm9A-4azpA:
24.3		 2qm9A-4azpA:
48.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  19
MET A  20
PRO A  38
ILE A 104
 None
75D  A 201 (-3.6A)
75D  A 201 (-4.4A)
75D  A 201 ( 4.4A)
 0.30A 2qm9A-4nnsA:
26.5		 2qm9A-4nnsA:
81.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvq FATTY ACID-BINDING
PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		4 TYR A  20
MET A  21
PRO A  39
ILE A 105
 None
 0.55A 2qm9A-5bvqA:
23.5		 2qm9A-5bvqA:
73.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		4 TYR A  22
MET A  23
PRO A  41
ILE A 108
 None
PAM  A 201 ( 3.8A)
PAM  A 201 ( 4.8A)
PAM  A 201 ( 4.7A)
 0.41A 2qm9A-5bvtA:
24.8		 2qm9A-5bvtA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gkb FATTY ACID BINDIN
PROTEIN, ISOFORM B

(Drosophila
melanogaster) 		PF00061
(Lipocalin) 		4 TYR A  19
MET A  20
PRO A  38
ILE A 103
 None
 0.43A 2qm9A-5gkbA:
20.6		 2qm9A-5gkbA:
42.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Homo sapiens) 		PF00061
(Lipocalin) 		4 TYR A  22
MET A  23
PRO A  41
ILE A 107
 65X  A 203 ( 4.7A)
65X  A 203 ( 3.9A)
65X  A 203 (-4.4A)
65X  A 203 (-3.9A)
 0.32A 2qm9A-5hz5A:
23.9		 2qm9A-5hz5A:
47.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA

(Geobacillus
stearothermophilus) 		no annotation 4 TYR B 219
MET B 363
PRO B 318
ILE B 349
 None
 1.46A 2qm9A-5ivlB:
undetectable		 2qm9A-5ivlB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6geb DOTB

(Legionella
pneumophila) 		no annotation 4 TYR A 256
MET A 232
PRO A 129
ILE A 145
 None
 1.44A 2qm9A-6gebA:
undetectable		 2qm9A-6gebA:
17.76