SIMILAR PATTERNS OF AMINO ACIDS FOR 2QJU_A_DSMA801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		5 ARG A 155
ILE A 167
PHE A 159
PHE A 130
LEU A 100
 None
 1.15A 2qjuA-1bs9A:
undetectable		 2qjuA-1bs9A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1del DEOXYNUCLEOSIDE
MONOPHOSPHATE KINASE

(Escherichia
virus T4) 		no annotation 5 ILE A  82
PHE A  61
ALA A  48
PHE A  47
LEU A  74
 None
 1.08A 2qjuA-1delA:
0.1		 2qjuA-1delA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 GLN C 172
ILE C 136
ALA C 142
PHE C 141
LEU C 181
 None
 1.01A 2qjuA-1ea9C:
undetectable		 2qjuA-1ea9C:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		5 LEU A  25
LEU A   5
ILE A 104
ALA A  31
ASP A 120
 None
 1.16A 2qjuA-1gk2A:
0.0		 2qjuA-1gk2A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 267
ARG A 274
ILE A 215
LEU A 173
ASP A 171
 None
 1.17A 2qjuA-1h4lA:
0.0		 2qjuA-1h4lA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens) 		PF09128
(RGS-like) 		5 LEU F 324
LEU F 317
ARG F 320
PHE F 311
LEU F 436
 None
 0.98A 2qjuA-1htjF:
undetectable		 2qjuA-1htjF:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 LEU A 663
ILE A  25
ALA A 668
PHE A  29
LEU A 737
 None
 1.14A 2qjuA-1j1wA:
0.0		 2qjuA-1j1wA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kon PROTEIN YEBC

(Escherichia
coli) 		PF01709
(Transcrip_reg) 		5 LEU A 219
LEU A 223
ARG A  13
GLN A  17
ILE A  97
 None
 1.09A 2qjuA-1konA:
0.7		 2qjuA-1konA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkt PROTEIN YFIR

(Bacillus
subtilis) 		PF00440
(TetR_N) 		5 LEU A  75
LEU A 141
ILE A  88
PHE A 134
LEU A 196
 None
 1.17A 2qjuA-1rktA:
0.0		 2qjuA-1rktA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		5 LEU A 233
ILE A 207
PHE A 292
ALA A 289
PHE A 253
 None
None
SO4  A 347 (-4.5A)
None
None
 1.19A 2qjuA-1tjrA:
undetectable		 2qjuA-1tjrA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukv GTP-BINDING PROTEIN
YPT1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 GLN Y 168
ILE Y  61
ALA Y 161
PHE Y 162
LEU Y  13
 None
 1.07A 2qjuA-1ukvY:
undetectable		 2qjuA-1ukvY:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU A  54
ILE A  51
PHE A  79
PHE A 150
LEU A  75
 None
 1.13A 2qjuA-1v0bA:
0.0		 2qjuA-1v0bA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 LEU A 141
LEU A 146
ILE A 138
LEU A 291
ASP A 290
 None
 1.13A 2qjuA-1xa0A:
undetectable		 2qjuA-1xa0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu GIANT HEMOGLOBINS B
CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		5 LEU B  89
LEU B  85
ILE B 138
ALA B  77
LEU B  72
 None
None
None
None
HEM  B 160 (-4.3A)
 1.09A 2qjuA-1yhuB:
undetectable		 2qjuA-1yhuB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzn GTP-BINDING PROTEIN
YPT1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 GLN A 168
ILE A  61
ALA A 161
PHE A 162
LEU A  13
 None
 1.11A 2qjuA-1yznA:
undetectable		 2qjuA-1yznA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		5 LEU A 140
ILE A  46
ALA A 134
PHE A  55
LEU A 148
 None
 1.18A 2qjuA-1z9nA:
undetectable		 2qjuA-1z9nA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae6 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		5 LEU A   9
ARG A   8
ALA A  55
LEU A  18
ASP A  14
 None
 1.15A 2qjuA-2ae6A:
undetectable		 2qjuA-2ae6A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		5 LEU A 130
ILE A  36
ALA A 124
PHE A  45
LEU A 138
 None
 1.19A 2qjuA-2apsA:
undetectable		 2qjuA-2apsA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 LEU A 147
ARG A 148
ILE A 185
LEU A 189
ASP A 201
 None
 1.12A 2qjuA-2f31A:
undetectable		 2qjuA-2f31A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF08442
(ATP-grasp_2) 		5 GLN A 110
ILE B 236
ALA B 200
PHE B 225
LEU B  11
 None
 1.13A 2qjuA-2fpgA:
undetectable		 2qjuA-2fpgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 177
LEU A 191
ILE A 179
PHE A 143
LEU A 159
 None
 1.16A 2qjuA-2ft3A:
undetectable		 2qjuA-2ft3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ARG A 325
ILE A  92
PHE A 124
LEU A 272
ASP A 276
 BME  A1592 ( 4.0A)
None
None
None
None
 0.89A 2qjuA-2j5cA:
undetectable		 2qjuA-2j5cA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j85 STIV B116

(Sulfolobus
turreted
icosahedral
virus 1) 		PF08960
(DUF1874) 		5 LEU A  57
LEU A  61
ILE A  84
PHE A  32
LEU A   6
 None
 1.12A 2qjuA-2j85A:
undetectable		 2qjuA-2j85A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvq GLUTATHIONE
S-TRANSFERASE

(Ochrobactrum
anthropi) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A  70
ILE A  17
ALA A  81
PHE A  82
ASP A 155
 None
 1.13A 2qjuA-2pvqA:
undetectable		 2qjuA-2pvqA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506

(Zoanthus sp.) 		PF01353
(GFP) 		5 LEU A 169
ILE A  60
PHE A 181
ALA A 103
PHE A 131
 None
 1.14A 2qjuA-2pxsA:
undetectable		 2qjuA-2pxsA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 LEU A 742
LEU A 744
ILE A 769
PHE A 758
LEU A 714
 None
 1.00A 2qjuA-2v26A:
2.4		 2qjuA-2v26A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus) 		no annotation 5 LEU A  51
ARG A  83
GLN A 116
ALA A  81
ASP A 134
 None
 1.05A 2qjuA-2x0fA:
undetectable		 2qjuA-2x0fA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE

(Homo sapiens) 		PF00004
(AAA) 		5 LEU A 793
LEU A 796
ALA A 800
PHE A 828
LEU A 770
 None
 1.02A 2qjuA-2x8aA:
undetectable		 2qjuA-2x8aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		5 LEU A 318
LEU A 316
ARG A 317
PHE A 148
ALA A 224
 BXO  A 355 ( 4.9A)
None
None
None
None
 1.07A 2qjuA-3a18A:
undetectable		 2qjuA-3a18A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		5 ILE A 452
ALA A 286
PHE A 438
LEU A 292
ASP A 290
 None
 1.16A 2qjuA-3ayxA:
undetectable		 2qjuA-3ayxA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		5 LEU A 193
ILE A 242
ALA A 149
LEU A 272
ASP A 269
 None
 1.18A 2qjuA-3e03A:
undetectable		 2qjuA-3e03A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Lactobacillus
delbrueckii) 		PF06325
(PrmA) 		5 LEU A 255
ILE A 258
ALA A 247
PHE A 273
LEU A 261
 None
 1.04A 2qjuA-3grzA:
undetectable		 2qjuA-3grzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Shewanella
denitrificans) 		PF01380
(SIS) 		5 LEU A 299
LEU A 185
ILE A 296
ALA A 187
ASP A 291
 None
 1.14A 2qjuA-3hbaA:
undetectable		 2qjuA-3hbaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 LEU A 115
LEU A 117
ILE A 210
PHE A 268
ALA A 235
 None
 1.18A 2qjuA-3heaA:
undetectable		 2qjuA-3heaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 LEU A 383
ARG A 407
ILE A  55
PHE A  39
ASP A 311
 None
 1.10A 2qjuA-3ialA:
undetectable		 2qjuA-3ialA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 LEU A 185
LEU A 188
ALA A 247
PHE A 251
LEU A 261
 GOL  A 398 ( 4.6A)
None
None
None
None
 1.05A 2qjuA-3is5A:
undetectable		 2qjuA-3is5A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lti DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Escherichia
coli) 		PF04561
(RNA_pol_Rpb2_2) 		5 LEU A 210
ILE A 425
PHE A 385
ALA A 206
LEU A 184
 None
MLY  A 422 ( 4.1A)
None
None
None
 1.13A 2qjuA-3ltiA:
undetectable		 2qjuA-3ltiA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lti DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Escherichia
coli) 		PF04561
(RNA_pol_Rpb2_2) 		5 LEU A 213
LEU A 210
ILE A 425
ALA A 206
LEU A 184
 MLY  A 422 ( 4.1A)
None
MLY  A 422 ( 4.1A)
None
None
 1.06A 2qjuA-3ltiA:
undetectable		 2qjuA-3ltiA:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 LEU A  25
LEU A  29
ARG A  30
PHE A 253
ALA A 319
 LEU  A 601 (-4.9A)
None
None
LEU  A 601 (-4.2A)
None
 1.06A 2qjuA-3mpnA:
68.0		 2qjuA-3mpnA:
99.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		10 LEU A  25
LEU A  29
GLN A  34
ILE A 111
PHE A 253
ALA A 319
PHE A 320
LEU A 400
ASP A 401
ASP A 404
 LEU  A 601 (-4.9A)
None
None
None
LEU  A 601 (-4.2A)
None
None
None
None
None
 0.43A 2qjuA-3mpnA:
68.0		 2qjuA-3mpnA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 LEU A 306
LEU A 308
ILE A 255
ALA A 272
PHE A 225
 None
 1.16A 2qjuA-3n2xA:
undetectable		 2qjuA-3n2xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT
PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans;
Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU B  74
LEU B  73
GLN A 643
ILE B 114
ALA B 269
 None
 1.14A 2qjuA-3n6rB:
undetectable		 2qjuA-3n6rB:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A  15
LEU A 134
ARG A 133
LEU A 129
ASP A  18
 None
 0.90A 2qjuA-3nwrA:
undetectable		 2qjuA-3nwrA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		5 LEU A 205
LEU A 208
ARG A 206
ILE A 183
ASP A 242
 None
 1.07A 2qjuA-3nx3A:
undetectable		 2qjuA-3nx3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 136
ARG A 133
ILE A 149
ALA A 159
ASP A 153
 None
 1.12A 2qjuA-3pwzA:
undetectable		 2qjuA-3pwzA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q62 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Yersinia pestis) 		PF07977
(FabA) 		5 ARG A   5
ILE A  40
PHE A  93
LEU A  13
ASP A  12
 None
 0.97A 2qjuA-3q62A:
undetectable		 2qjuA-3q62A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhq SAG0897 FAMILY
CRISPR-ASSOCIATED
PROTEIN

(Streptococcus
agalactiae) 		PF09711
(Cas_Csn2) 		5 LEU A  21
LEU A 196
ILE A   4
PHE A  36
LEU A  47
 None
 1.17A 2qjuA-3qhqA:
2.6		 2qjuA-3qhqA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsl PUTATIVE EXPORTED
PROTEIN

(Bordetella
bronchiseptica) 		PF13379
(NMT1_2) 		5 ILE A  37
PHE A 109
ALA A 252
PHE A  59
LEU A  50
 None
 1.12A 2qjuA-3qslA:
undetectable		 2qjuA-3qslA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkd CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		5 ARG A 460
ALA A 507
PHE A 462
LEU A 471
ASP A 469
 None
 0.93A 2qjuA-3rkdA:
undetectable		 2qjuA-3rkdA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF03320
(FBPase_glpX) 		5 LEU A 302
LEU A 318
ILE A 205
ALA A 293
PHE A 292
 None
 0.92A 2qjuA-3rplA:
undetectable		 2qjuA-3rplA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ARG A 370
ILE A 120
PHE A 372
LEU A 549
ASP A 553
 None
 0.71A 2qjuA-3s9vA:
1.4		 2qjuA-3s9vA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip CASPASE

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		5 LEU A 111
GLN A 108
ILE A 114
ALA A 104
LEU A  72
 None
 0.88A 2qjuA-3sipA:
undetectable		 2qjuA-3sipA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 146
ARG A 273
ILE A  91
ASP A 434
ASP A 463
 None
 1.00A 2qjuA-3v9eA:
undetectable		 2qjuA-3v9eA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 365
GLN A 355
ILE A 241
LEU A 499
ASP A 498
 None
 1.14A 2qjuA-3vskA:
undetectable		 2qjuA-3vskA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		5 LEU A 318
LEU A 316
ARG A 317
PHE A 148
ALA A 224
 HEM  A 501 ( 4.6A)
None
None
None
None
 1.05A 2qjuA-3w08A:
undetectable		 2qjuA-3w08A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		5 LEU B  88
LEU B  84
ILE B 137
ALA B  76
LEU B  71
 None
None
None
None
HEM  B 201 (-4.4A)
 1.06A 2qjuA-3wcuB:
undetectable		 2qjuA-3wcuB:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 LEU A 257
ILE A 162
PHE A 144
ALA A 159
LEU A 214
 None
 1.10A 2qjuA-3zzuA:
undetectable		 2qjuA-3zzuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 LEU A 319
ILE A 322
ALA A 335
PHE A 336
LEU A 324
 None
 1.16A 2qjuA-4cp6A:
undetectable		 2qjuA-4cp6A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		5 LEU A 223
LEU A 226
ARG A 224
ILE A 201
ASP A 259
 None
 1.07A 2qjuA-4e77A:
undetectable		 2qjuA-4e77A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 LEU A 146
ILE A  55
ALA A  43
PHE A  44
LEU A 136
 None
 1.00A 2qjuA-4f7zA:
1.1		 2qjuA-4f7zA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		6 LEU A 131
LEU A 162
ILE A 150
ALA A 240
PHE A 223
LEU A 154
 None
 1.20A 2qjuA-4gekA:
undetectable		 2qjuA-4gekA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens) 		no annotation 5 LEU A 123
LEU A 201
ARG A 202
PHE A 160
LEU A 224
 None
None
GOL  A 401 (-4.1A)
None
None
 1.17A 2qjuA-4gxbA:
undetectable		 2qjuA-4gxbA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6n UBIQUITIN
CARBOXYL-HYDROLASE

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		5 LEU A  36
LEU A 218
ILE A 199
ALA A 220
PHE A  49
 None
 0.83A 2qjuA-4i6nA:
undetectable		 2qjuA-4i6nA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 LEU A 131
LEU A 162
ILE A 150
ALA A 240
LEU A 154
 None
 1.13A 2qjuA-4iwnA:
undetectable		 2qjuA-4iwnA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k17 LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A

(Mus musculus) 		PF13516
(LRR_6) 		5 LEU A 270
ILE A 281
PHE A 262
PHE A 300
LEU A 312
 None
 1.00A 2qjuA-4k17A:
undetectable		 2qjuA-4k17A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 134
LEU A 110
ARG A 135
ALA A  89
ASP A 137
 None
 1.19A 2qjuA-4kt1A:
undetectable		 2qjuA-4kt1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		5 LEU A 117
ILE A  24
ALA A 111
PHE A  33
LEU A 125
 None
 1.18A 2qjuA-4l05A:
undetectable		 2qjuA-4l05A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn7 PUTATIVE
UNCHARACTERIZED
PROTEIN TA0848

(Thermoplasma
acidophilum) 		PF13185
(GAF_2) 		5 LEU A  18
ILE A 108
ALA A 115
PHE A 116
ASP A  26
 None
 1.16A 2qjuA-4mn7A:
0.8		 2qjuA-4mn7A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 LEU A 306
LEU A 308
ILE A 255
ALA A 272
PHE A 225
 None
 1.19A 2qjuA-4oe7A:
undetectable		 2qjuA-4oe7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		5 ARG A 460
ALA A 507
PHE A 462
LEU A 471
ASP A 469
 None
 0.99A 2qjuA-4pljA:
undetectable		 2qjuA-4pljA:
14.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		6 LEU A  29
ARG A  34
ILE A 111
PHE A 230
ASP A 382
ASP A 385
 None
None
None
TRP  A 601 (-4.4A)
None
None
 0.82A 2qjuA-4us4A:
40.4		 2qjuA-4us4A:
33.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 LEU A 826
LEU A 808
ILE A 786
PHE A 807
LEU A 769
 None
 1.00A 2qjuA-4xmvA:
undetectable		 2qjuA-4xmvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 LEU A 545
ILE A 520
PHE A 500
ALA A 684
LEU A 504
 None
 1.18A 2qjuA-4yzwA:
1.8		 2qjuA-4yzwA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdv MICROTUBULE-ASSOCIAT
ED PROTEINS 1A/1B
LIGHT CHAIN 3A

(Homo sapiens) 		PF02991
(Atg8) 		5 LEU A  63
ILE A  35
PHE A  79
PHE A  52
ASP A  48
 None
 1.13A 2qjuA-4zdvA:
undetectable		 2qjuA-4zdvA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 GLN E 457
ILE E 500
ALA E 465
PHE E 460
LEU E 445
 None
 1.19A 2qjuA-5e24E:
undetectable		 2qjuA-5e24E:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 336
ILE A 246
PHE A  24
ALA A 343
LEU A 122
 None
 1.09A 2qjuA-5eytA:
undetectable		 2qjuA-5eytA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		5 LEU A 372
LEU A 376
ARG A 373
ILE A 306
ASP A 277
 None
 1.19A 2qjuA-5h5mA:
undetectable		 2qjuA-5h5mA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl8 TYPE II SECRETION
SYSTEM PROTEIN L

(Klebsiella
pneumoniae) 		PF12693
(GspL_C) 		5 LEU A 390
ILE A 353
ALA A 368
PHE A 364
LEU A 329
 None
 1.18A 2qjuA-5hl8A:
undetectable		 2qjuA-5hl8A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 LEU A 232
LEU A 271
ILE A 305
PHE A 262
LEU A 277
 None
 1.13A 2qjuA-5k8rA:
undetectable		 2qjuA-5k8rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA

(Staphylococcus
aureus) 		PF03255
(ACCA) 		5 LEU A 287
ILE A 189
ALA A 285
LEU A 211
ASP A 259
 None
 1.12A 2qjuA-5kdrA:
undetectable		 2qjuA-5kdrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms7 LEGIONELLA
PNEUMOPHILA EFFECTOR
PROTEIN RAVZ

(Legionella
pneumophila) 		no annotation 5 LEU A  71
LEU A  74
ILE A 301
ALA A  81
LEU A 293
 None
 0.99A 2qjuA-5ms7A:
undetectable		 2qjuA-5ms7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 LEU B 107
LEU B 105
ALA B 172
LEU B 183
ASP B 179
 None
 1.14A 2qjuA-5of4B:
0.7		 2qjuA-5of4B:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 205
GLN A 211
ILE A 146
PHE A 244
LEU A 158
 None
 0.93A 2qjuA-5opjA:
undetectable		 2qjuA-5opjA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szp PROTOCADHERIN GAMMA
B7

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 LEU A 110
ILE A 200
PHE A 148
LEU A 170
ASP A 116
 None
 1.16A 2qjuA-5szpA:
undetectable		 2qjuA-5szpA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 284
LEU A 288
ILE A 329
PHE A 315
LEU A 313
 None
 1.19A 2qjuA-5u7qA:
undetectable		 2qjuA-5u7qA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A  92
ILE A 147
ALA A 137
PHE A 144
LEU A 195
 None
 1.18A 2qjuA-5vm1A:
undetectable		 2qjuA-5vm1A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG

(Bombyx mori) 		PF00567
(TUDOR) 		5 GLN A  19
ILE A 192
PHE A  20
PHE A  16
LEU A 194
 None
 1.15A 2qjuA-5vqhA:
undetectable		 2qjuA-5vqhA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcb PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 5 LEU A  95
ILE A  92
ALA A 104
PHE A 103
LEU A  57
 None
 1.16A 2qjuA-5xcbA:
undetectable		 2qjuA-5xcbA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 LEU A 259
LEU A 272
ILE A 257
PHE A 304
LEU A 286
 None
 1.17A 2qjuA-5xdrA:
undetectable		 2qjuA-5xdrA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 LEU A 527
LEU A 556
ILE A 487
ALA A 560
PHE A 485
 None
 0.98A 2qjuA-5yj6A:
undetectable		 2qjuA-5yj6A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7j 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Vibrio cholerae) 		no annotation 5 ARG A   5
ILE A  40
PHE A  93
LEU A  13
ASP A  12
 None
 1.02A 2qjuA-6b7jA:
undetectable		 2qjuA-6b7jA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 5 LEU A 257
ILE A 162
PHE A 144
ALA A 159
LEU A 214
 None
 1.11A 2qjuA-6bk7A:
undetectable		 2qjuA-6bk7A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 5 LEU A 109
ARG A 107
ILE A 121
ALA A  62
PHE A  20
 None
 0.93A 2qjuA-6brmA:
undetectable		 2qjuA-6brmA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 5 LEU A 109
ILE A 121
ALA A  62
PHE A  20
LEU A 119
 None
 1.06A 2qjuA-6brmA:
undetectable		 2qjuA-6brmA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0b TOXIN B

(Clostridioides
difficile) 		no annotation 5 LEU A1647
GLN A1620
ILE A1684
PHE A1623
LEU A1566
 None
 1.15A 2qjuA-6c0bA:
undetectable		 2qjuA-6c0bA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 5 LEU A  89
LEU A 111
ALA A 103
PHE A  99
LEU A  38
 None
 1.18A 2qjuA-6cj7A:
undetectable		 2qjuA-6cj7A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis) 		no annotation 5 LEU A 425
ILE A 301
PHE A 343
ALA A 423
LEU A 226
 None
 1.15A 2qjuA-6cxdA:
undetectable		 2qjuA-6cxdA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 5 LEU A  96
LEU A  95
ARG A  97
PHE A  60
ASP A 101
 None
 1.16A 2qjuA-6d95A:
undetectable		 2qjuA-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 5 LEU A 370
LEU A 101
ALA A 164
PHE A 102
LEU A 158
 None
NAD  A 502 (-4.6A)
None
None
None
 1.14A 2qjuA-6dftA:
undetectable		 2qjuA-6dftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z UPF0434 FAMILY
PROTEIN

(Haloferax
volcanii) 		no annotation 5 LEU C  20
LEU C  35
ARG C  34
ILE C  30
ASP C  23
 GOL  C 101 (-4.4A)
GOL  C 101 (-4.8A)
None
None
None
 1.16A 2qjuA-6f5zC:
undetectable		 2qjuA-6f5zC:
8.96