SIMILAR PATTERNS OF AMINO ACIDS FOR 2QHF_A_NCAA493

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE


(Salmonella
enterica)
PF00291
(PALP)
5 ALA A  29
ILE A  22
ILE A 267
ALA A 269
VAL A 277
None
1.18A 2qhfA-1d6sA:
undetectable
2qhfA-1d6sA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
desulfuricans)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
5 ALA A 784
ILE A 883
ALA A 896
ALA A 819
VAL A 816
None
1.05A 2qhfA-1dgjA:
1.7
2qhfA-1dgjA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 ALA A 517
ILE A 622
ILE A 538
ALA A 524
ALA A 546
None
1.07A 2qhfA-1dlcA:
0.0
2qhfA-1dlcA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus)
PF13365
(Trypsin_2)
5 ALA A 116
THR A  62
ILE A 104
ALA A  70
VAL A  42
None
1.11A 2qhfA-1dt2A:
0.0
2qhfA-1dt2A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE


(Methanopyrus
kandleri)
PF00296
(Bac_luciferase)
5 ALA A  26
ILE A 328
ILE A  23
ALA A  34
VAL A 324
None
1.12A 2qhfA-1ezwA:
0.0
2qhfA-1ezwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE
UBIQUINOL OXIDASE


(Escherichia
coli;
Escherichia
coli)
PF00115
(COX1)
PF00116
(COX2)
PF06481
(COX_ARM)
5 ALA B 104
THR B 107
ILE B 100
ALA A 402
VAL A 403
None
None
HEO  A1002 (-4.4A)
None
None
1.09A 2qhfA-1fftB:
undetectable
2qhfA-1fftB:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gns SUBTILISIN BPN'

(Bacillus
amyloliquefaciens)
PF00082
(Peptidase_S8)
5 ALA A 230
ILE A 175
ILE A 234
ALA A 273
VAL A 198
None
1.14A 2qhfA-1gnsA:
0.1
2qhfA-1gnsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE


(Escherichia
coli)
PF03740
(PdxJ)
6 ALA A 222
ILE A 218
ILE A  13
ALA A  30
ALA A  34
VAL A 231
None
1.40A 2qhfA-1ixpA:
undetectable
2qhfA-1ixpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION


(Escherichia
coli)
PF08943
(CsiD)
5 ALA A  99
ILE A  97
MET A 176
ALA A 115
VAL A 118
None
1.02A 2qhfA-1jr7A:
undetectable
2qhfA-1jr7A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leh LEUCINE
DEHYDROGENASE


(Lysinibacillus
sphaericus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 ALA A  43
THR A 112
ILE A 126
ILE A  83
ALA A  27
None
0.96A 2qhfA-1lehA:
undetectable
2qhfA-1lehA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1


(Homo sapiens)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 THR A 132
ILE A 136
ILE A 179
ALA A 190
ALA A 193
None
1.20A 2qhfA-1mx3A:
undetectable
2qhfA-1mx3A:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus)
PF01264
(Chorismate_synt)
8 ARG A  44
ALA A 136
THR A 139
ILE A 260
MET A 320
ALA A 352
ALA A 356
VAL A 359
None
0.48A 2qhfA-1q1lA:
40.9
2qhfA-1q1lA:
44.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus)
PF01264
(Chorismate_synt)
5 ARG A  44
MET A 320
ILE A 323
ALA A 352
ALA A 356
None
0.92A 2qhfA-1q1lA:
40.9
2qhfA-1q1lA:
44.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE


(Pseudomonas
putida)
PF07992
(Pyr_redox_2)
PF14759
(Reductase_C)
5 ALA A  15
ILE A 312
ALA A 286
ALA A 281
VAL A 107
FAD  A 749 (-3.3A)
None
None
None
None
1.14A 2qhfA-1q1rA:
undetectable
2qhfA-1q1rA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q48 NIFU-LIKE PROTEIN

(Haemophilus
influenzae)
PF01592
(NifU_N)
5 ALA A  85
ILE A  73
ILE A  45
ALA A 117
ALA A 113
None
0.90A 2qhfA-1q48A:
undetectable
2qhfA-1q48A:
14.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae)
PF01264
(Chorismate_synt)
9 ARG A  39
ARG A  45
ALA A 133
THR A 136
ILE A 250
MET A 310
ALA A 342
ALA A 346
VAL A 349
EPS  A5001 (-2.8A)
EPS  A5001 ( 2.7A)
FMN  A4001 ( 3.3A)
FMN  A4001 ( 4.5A)
None
None
FMN  A4001 (-3.5A)
FMN  A4001 ( 4.0A)
None
0.47A 2qhfA-1qxoA:
49.5
2qhfA-1qxoA:
44.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans)
PF03598
(CdhC)
5 ALA A 606
ILE A 604
MET A 629
ILE A 627
VAL A 638
None
None
GOL  A 967 (-4.8A)
None
None
1.20A 2qhfA-1ru3A:
undetectable
2qhfA-1ru3A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE


(Thermus
thermophilus)
PF02219
(MTHFR)
5 ALA A 172
ILE A 134
ALA A 127
ALA A 105
VAL A 144
None
None
FAD  A 300 (-3.3A)
None
None
1.06A 2qhfA-1v93A:
undetectable
2qhfA-1v93A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE


(Bacillus
subtilis)
PF03102
(NeuB)
PF08666
(SAF)
5 ALA A  21
ILE A  38
ALA A  44
ALA A  42
VAL A 103
None
1.05A 2qhfA-1vliA:
undetectable
2qhfA-1vliA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE


(Methanosarcina
barkeri)
PF00296
(Bac_luciferase)
5 ARG A 243
ALA A 186
ILE A 298
ILE A 175
ALA A 177
None
1.05A 2qhfA-1z69A:
undetectable
2qhfA-1z69A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a18 CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK HOMOLOG 4


(Synechocystis
sp. PCC 6803)
PF00936
(BMC)
5 ALA A  72
THR A  12
ILE A  18
ALA A  65
ALA A  21
NH4  A 126 (-4.3A)
None
None
None
None
1.17A 2qhfA-2a18A:
undetectable
2qhfA-2a18A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B


(Methanocaldococcus
jannaschii)
PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2)
5 ILE A 272
ILE A 279
ALA A 300
ALA A 315
VAL A 267
None
1.09A 2qhfA-2apoA:
undetectable
2qhfA-2apoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE


(Salmonella
enterica)
PF00006
(ATP-synt_ab)
5 ALA A 237
MET A 271
ILE A 209
ALA A 250
ALA A 253
None
1.12A 2qhfA-2dpyA:
undetectable
2qhfA-2dpyA:
25.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis)
PF01264
(Chorismate_synt)
7 ALA A 138
THR A 141
ILE A 317
ARG A 341
ALA A 346
ALA A 349
VAL A 353
None
1.31A 2qhfA-2g85A:
59.1
2qhfA-2g85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis)
PF01264
(Chorismate_synt)
10 ARG A  40
ALA A 138
THR A 141
ILE A 255
MET A 314
ILE A 317
ARG A 341
ALA A 346
ALA A 350
VAL A 353
None
0.48A 2qhfA-2g85A:
59.1
2qhfA-2g85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis)
PF01264
(Chorismate_synt)
5 ILE A 258
ILE A 317
ARG A 341
ALA A 346
ALA A 350
None
0.85A 2qhfA-2g85A:
59.1
2qhfA-2g85A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE


(Sus scrofa)
PF05187
(ETF_QO)
PF13450
(NAD_binding_8)
5 ALA A  50
ILE A 381
ILE A 352
ALA A 212
VAL A  38
None
1.09A 2qhfA-2gmhA:
undetectable
2qhfA-2gmhA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdh COHESIN

(Archaeoglobus
fulgidus)
PF00963
(Cohesin)
5 ALA A  30
THR A   6
ILE A   8
ILE A  81
VAL A 145
None
1.11A 2qhfA-2xdhA:
undetectable
2qhfA-2xdhA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum)
PF06964
(Alpha-L-AF_C)
5 ARG A  73
ALA A 419
ILE A  79
ILE A 417
ALA A 415
None
1.16A 2qhfA-2y2wA:
undetectable
2qhfA-2y2wA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN


(Saccharophagus
degradans)
PF07632
(DUF1593)
5 ARG A 526
ALA A 633
ILE A 605
ILE A 630
ALA A 644
None
1.19A 2qhfA-2yhgA:
undetectable
2qhfA-2yhgA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5m OLIGOGALACTURONATE
LYASE


(Vibrio
parahaemolyticus)
PF14583
(Pectate_lyase22)
5 THR A 327
ILE A 266
ILE A 246
ALA A 251
VAL A 279
None
1.20A 2qhfA-3c5mA:
undetectable
2qhfA-3c5mA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d79 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0734


(Pyrococcus
horikoshii)
PF01472
(PUA)
PF09183
(DUF1947)
5 ILE A 111
ILE A 118
ALA A 140
ALA A 155
VAL A 106
None
1.12A 2qhfA-3d79A:
undetectable
2qhfA-3d79A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3a POSSIBLE PEROXIDASE
BPOC


(Mycobacterium
tuberculosis)
PF12697
(Abhydrolase_6)
5 ALA A  90
THR A 112
MET A  97
ALA A 107
VAL A 222
None
0.98A 2qhfA-3e3aA:
undetectable
2qhfA-3e3aA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD


(Paraburkholderia
xenovorans)
PF05853
(BKACE)
5 ALA A  40
ILE A   9
ILE A  48
ALA A  80
ALA A  46
None
1.02A 2qhfA-3e49A:
undetectable
2qhfA-3e49A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed0 (3R)-HYDROXYMYRISTOY
L-ACYL CARRIER
PROTEIN DEHYDRATASE


(Helicobacter
pylori)
PF07977
(FabA)
5 ILE A 104
MET A  74
ILE A  70
ALA A 147
ALA A 149
None
1.13A 2qhfA-3ed0A:
undetectable
2qhfA-3ed0A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE


(Agrobacterium
fabrum)
PF13561
(adh_short_C2)
5 ALA A  60
ILE A  51
ALA A  14
ALA A  23
VAL A  33
None
1.13A 2qhfA-3edmA:
undetectable
2qhfA-3edmA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en0 CYANOPHYCINASE

(Synechocystis
sp. PCC 6803)
PF03575
(Peptidase_S51)
5 ALA A 205
ILE A 169
ILE A 199
ALA A 135
VAL A 166
None
1.09A 2qhfA-3en0A:
undetectable
2qhfA-3en0A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'


(Sulfolobus
solfataricus)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 ALA A 506
THR A 510
ILE A 552
ILE A 603
ALA A 602
None
0.79A 2qhfA-3hkzA:
undetectable
2qhfA-3hkzA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A


(Archaeoglobus
fulgidus)
PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase)
5 ILE A 662
ILE A 406
ALA A 411
ALA A 415
VAL A 418
None
1.00A 2qhfA-3j09A:
undetectable
2qhfA-3j09A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A


(Archaeoglobus
fulgidus)
PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase)
5 ILE A 662
ILE A 648
ALA A 411
ALA A 415
VAL A 418
None
1.08A 2qhfA-3j09A:
undetectable
2qhfA-3j09A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kje CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE
COMPLEX, ACCESSORY
PROTEIN COOC


(Carboxydothermus
hydrogenoformans)
PF01656
(CbiA)
5 ALA A 178
ILE A 143
ALA A   6
ALA A   4
VAL A 154
None
1.18A 2qhfA-3kjeA:
undetectable
2qhfA-3kjeA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3miz PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN,
LACI FAMILY


(Rhizobium etli)
PF13377
(Peripla_BP_3)
5 ALA A 255
ILE A 183
ILE A 275
ALA A 234
VAL A 230
None
1.20A 2qhfA-3mizA:
undetectable
2qhfA-3mizA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT


(Ruegeria
pomeroyi)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 ALA A 130
THR A 134
ILE A 112
ALA A  91
VAL A  90
None
1.00A 2qhfA-3n6rA:
undetectable
2qhfA-3n6rA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4f SPERMIDINE SYNTHASE

(Escherichia
coli)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
5 ILE A  62
MET A  66
ILE A 268
ALA A 272
ALA A 221
None
1.20A 2qhfA-3o4fA:
undetectable
2qhfA-3o4fA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE


(Mycobacterium
tuberculosis)
PF02581
(TMP-TENI)
5 THR A  15
ILE A  39
ILE A  66
ALA A  25
ALA A  28
None
1.04A 2qhfA-3o63A:
undetectable
2qhfA-3o63A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3paj NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE,
CARBOXYLATING


(Vibrio cholerae)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 ALA A 197
ILE A 194
ALA A 226
ALA A 228
VAL A 210
None
1.04A 2qhfA-3pajA:
undetectable
2qhfA-3pajA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE


(Yersinia pestis)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 ALA A 273
ILE A  70
ALA A  69
ALA A 296
VAL A 265
None
1.12A 2qhfA-3pyzA:
undetectable
2qhfA-3pyzA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb SINGLE DOMAIN
ANTIBODY VHH


(Lama glama)
PF07686
(V-set)
5 ALA A  35
ILE A  71
ILE A 110
ALA A  98
VAL A  80
None
1.16A 2qhfA-3stbA:
undetectable
2qhfA-3stbA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus)
PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C)
5 ALA A 377
THR A 453
ILE A 451
ILE A 397
VAL A 363
None
1.13A 2qhfA-3t05A:
undetectable
2qhfA-3t05A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Campylobacter
jejuni)
PF00290
(Trp_syntA)
5 ALA A 109
ILE A  97
ILE A 139
ALA A 116
VAL A  92
None
1.09A 2qhfA-3thaA:
undetectable
2qhfA-3thaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqv NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Francisella
tularensis)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 ALA A 188
ILE A 185
ALA A 217
ALA A 219
VAL A 201
None
1.17A 2qhfA-3tqvA:
undetectable
2qhfA-3tqvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4


(Thermotoga
neapolitana)
PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C)
5 THR A  32
ILE A  34
ILE A 347
ALA A  22
VAL A  62
None
1.12A 2qhfA-3u95A:
undetectable
2qhfA-3u95A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE


(Archaeoglobus
fulgidus)
PF02516
(STT3)
5 ALA A 120
ILE A 164
ILE A 144
ALA A 433
ALA A 167
None
1.15A 2qhfA-3wajA:
undetectable
2qhfA-3wajA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axj ETHANOLAMINE
CARBOXYSOME
STRUCTURAL PROTEIN


(Clostridioides
difficile)
PF00936
(BMC)
5 ARG A  68
ALA A  24
ALA A  63
ALA A  66
VAL A  69
None
1.07A 2qhfA-4axjA:
undetectable
2qhfA-4axjA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE


(Flavobacterium
sp. 141-8)
PF13561
(adh_short_C2)
5 ILE A  74
MET A  45
ILE A  19
ALA A  81
ALA A  77
None
1.11A 2qhfA-4cr6A:
undetectable
2qhfA-4cr6A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA


(Corynebacterium
diphtheriae)
PF01625
(PMSR)
5 THR A 174
ILE A 176
ILE A  48
ALA A 115
VAL A 157
None
1.15A 2qhfA-4d7lA:
undetectable
2qhfA-4d7lA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Bacillus
anthracis)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ALA A  95
THR A 119
ILE A 117
ILE A   6
VAL A 322
None
1.16A 2qhfA-4dibA:
undetectable
2qhfA-4dibA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN


(Labrenzia
alexandrii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A 330
MET A 287
ILE A 312
ALA A 302
ALA A 298
None
1.20A 2qhfA-4e5tA:
undetectable
2qhfA-4e5tA:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ecd CHORISMATE SYNTHASE

(Bifidobacterium
longum)
PF01264
(Chorismate_synt)
6 THR A 140
ILE A 255
MET A 315
ALA A 347
ALA A 351
VAL A 354
None
0.72A 2qhfA-4ecdA:
36.2
2qhfA-4ecdA:
59.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE


(Burkholderia
thailandensis)
PF00795
(CN_hydrolase)
PF02540
(NAD_synthase)
5 ILE A 464
MET A 346
ALA A 314
ALA A 310
VAL A 307
None
0.96A 2qhfA-4f4hA:
undetectable
2qhfA-4f4hA:
25.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster)
PF04389
(Peptidase_M28)
5 ALA A 155
ILE A  73
ILE A  68
ALA A  67
VAL A  85
None
1.01A 2qhfA-4faiA:
undetectable
2qhfA-4faiA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A


(Catenulispora
acidiphila)
PF13768
(VWA_3)
5 ARG A 147
ALA A 102
ILE A  59
ALA A 143
ALA A 145
None
1.15A 2qhfA-4fx5A:
undetectable
2qhfA-4fx5A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4g (3R)-HYDROXYMYRISTOY
L-[ACYL-CARRIER-PROT
EIN] DEHYDRATASE


(Burkholderia
thailandensis)
PF07977
(FabA)
5 ALA A  76
ILE A  72
ALA A 147
ALA A 135
VAL A 121
None
1.07A 2qhfA-4h4gA:
undetectable
2qhfA-4h4gA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i83 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ


(Neisseria
meningitidis)
PF07977
(FabA)
5 ALA A  70
ILE A  66
ALA A 140
ALA A 128
VAL A 114
None
1.10A 2qhfA-4i83A:
undetectable
2qhfA-4i83A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE


(Bacillus
anthracis)
PF04551
(GcpE)
5 ALA D  66
THR D  36
ALA D  95
ALA D  83
VAL D  59
None
1.15A 2qhfA-4mwaD:
undetectable
2qhfA-4mwaD:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nae HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE


(Geobacillus
kaustophilus)
PF01884
(PcrB)
5 THR A 222
ILE A 190
ALA A 215
ALA A 211
VAL A 208
None
None
None
None
1GP  A 301 ( 4.6A)
1.10A 2qhfA-4naeA:
undetectable
2qhfA-4naeA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE


(Thermococcus
kodakarensis)
PF03009
(GDPD)
5 ILE A  38
ILE A   8
ARG A   4
ALA A  35
VAL A  31
None
1.16A 2qhfA-4oecA:
undetectable
2qhfA-4oecA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN


(Sulfolobus
acidocaldarius)
PF01266
(DAO)
5 ALA A  20
ILE A 315
ILE A 286
ALA A 156
VAL A   8
None
1.12A 2qhfA-4opuA:
undetectable
2qhfA-4opuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Thermotoga
maritima)
PF00496
(SBP_bac_5)
5 ALA A 304
ILE A 397
MET A 431
ALA A 393
VAL A 396
None
1.06A 2qhfA-4pfwA:
undetectable
2qhfA-4pfwA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1s CINNAMOYL COA
REDUCTASE


(Petunia x
hybrida)
PF01370
(Epimerase)
5 ILE A 107
ILE A  75
ALA A 113
ALA A 111
VAL A 177
None
0.95A 2qhfA-4r1sA:
undetectable
2qhfA-4r1sA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN


(Chloroflexus
aurantiacus)
PF13407
(Peripla_BP_4)
5 ALA A 146
THR A 144
ILE A 141
ALA A 126
ALA A 123
None
1.12A 2qhfA-4rxuA:
undetectable
2qhfA-4rxuA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE


(Homo sapiens)
PF01207
(Dus)
5 ILE A 140
MET A  88
ILE A 110
ALA A 100
ALA A  96
None
1.08A 2qhfA-4wfsA:
undetectable
2qhfA-4wfsA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis)
PF01494
(FAD_binding_3)
5 ALA A  10
ILE A   7
ILE A 114
ALA A 107
ALA A  18
None
0.88A 2qhfA-4x4jA:
undetectable
2qhfA-4x4jA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae)
PF00294
(PfkB)
5 ALA A 188
THR A 192
ILE A 219
ALA A 202
ALA A 206
None
0.98A 2qhfA-4x8fA:
undetectable
2qhfA-4x8fA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9d PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA


(Escherichia
coli)
PF02917
(Pertussis_S1)
5 THR A  53
ILE A  82
ILE A  87
ALA A  84
VAL A   7
None
1.16A 2qhfA-4z9dA:
undetectable
2qhfA-4z9dA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zw0 3-HYDROXYACYL-[ACYL-
CARRIER-PROTEIN]
DEHYDRATASE FABZ


(Candidatus
Liberibacter
asiaticus)
PF07977
(FabA)
5 ILE A  97
MET A  72
ILE A  68
ALA A 140
ALA A 142
None
1.19A 2qhfA-4zw0A:
undetectable
2qhfA-4zw0A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE


(Thymus vulgaris)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 ARG A 564
ILE A 481
ILE A 488
ALA A 559
VAL A 556
ARG  A 564 ( 0.6A)
ILE  A 481 ( 0.7A)
ILE  A 488 ( 0.7A)
ALA  A 559 ( 0.0A)
VAL  A 556 ( 0.6A)
1.18A 2qhfA-5c05A:
undetectable
2qhfA-5c05A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE


(Corynebacterium
glutamicum)
PF00701
(DHDPS)
5 THR A 107
ILE A 140
ARG A  60
ALA A  53
VAL A 144
None
1.20A 2qhfA-5c54A:
undetectable
2qhfA-5c54A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwc DESIGNED HELICAL
REPEAT PROTEIN


(synthetic
construct)
no annotation 5 ALA A  87
ILE A 127
ILE A 113
ALA A 134
ALA A 130
None
1.11A 2qhfA-5cwcA:
undetectable
2qhfA-5cwcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwm DESIGNED HELICAL
REPEAT PROTEIN


(synthetic
construct)
no annotation 5 ALA A  97
ILE A 137
ALA A 146
ALA A 150
VAL A 153
None
0.76A 2qhfA-5cwmA:
undetectable
2qhfA-5cwmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum)
PF00232
(Glyco_hydro_1)
5 THR A  11
ILE A  65
ILE A 415
ALA A 430
VAL A  70
None
1.13A 2qhfA-5dt5A:
undetectable
2qhfA-5dt5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1


(Homo sapiens)
PF16213
(DCB)
5 ALA A 174
ILE A 151
ILE A 131
ALA A 158
ALA A 154
None
None
None
None
CL  A 312 (-3.4A)
1.09A 2qhfA-5ee5A:
undetectable
2qhfA-5ee5A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep0 PUTATIVE REPRESSOR
PROTEIN LUXO


(Photobacterium
angustum)
PF00072
(Response_reg)
PF00158
(Sigma54_activat)
5 ARG A 277
ILE A 168
ALA A 182
ALA A 180
VAL A 279
None
1.20A 2qhfA-5ep0A:
undetectable
2qhfA-5ep0A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO


(Photobacterium
angustum)
PF00158
(Sigma54_activat)
5 ARG A 277
ILE A 168
ALA A 182
ALA A 180
VAL A 279
None
1.18A 2qhfA-5ep1A:
undetectable
2qhfA-5ep1A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frt DIMERIC (2FE-2S)
PROTEIN


(Azotobacter
vinelandii)
PF00111
(Fer2)
5 ALA A 101
THR A 104
ILE A  54
ILE A  38
ALA A  31
None
1.02A 2qhfA-5frtA:
undetectable
2qhfA-5frtA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk2 KETOSYNTHASE STLD

(Photorhabdus
laumondii)
PF08541
(ACP_syn_III_C)
5 ALA A  92
THR A 151
ALA A  67
ALA A  71
VAL A  74
None
1.03A 2qhfA-5gk2A:
undetectable
2qhfA-5gk2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn5 GLYCEROL KINASE

(Trypanosoma
brucei)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 THR A 246
ILE A  78
ILE A  62
ALA A 241
VAL A 231
None
1.20A 2qhfA-5gn5A:
undetectable
2qhfA-5gn5A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwx 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE


(Bacillus
subtilis)
PF02542
(YgbB)
5 ILE A  95
ILE A 155
ALA A  52
ALA A  48
VAL A  45
None
1.16A 2qhfA-5iwxA:
undetectable
2qhfA-5iwxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7v DESIGNED PROTEIN
HR00C3


(synthetic
construct)
no annotation 5 ALA A 135
ILE A 113
ILE A  71
ALA A 120
ALA A 117
None
1.19A 2qhfA-5k7vA:
undetectable
2qhfA-5k7vA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7v DESIGNED PROTEIN
HR00C3


(synthetic
construct)
no annotation 5 ALA A 177
ILE A 133
ILE A 113
ALA A 140
ALA A 137
None
1.19A 2qhfA-5k7vA:
undetectable
2qhfA-5k7vA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis)
PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 THR A 748
ILE A 755
ILE A 741
ALA A 777
VAL A 525
None
1.12A 2qhfA-5vywA:
undetectable
2qhfA-5vywA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR


(Mycobacterium
tuberculosis)
no annotation 5 ARG A  35
THR A 199
ALA A  34
ALA A  30
VAL A  27
None
1.11A 2qhfA-5w5bA:
undetectable
2qhfA-5w5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb0 FUSION GLYCOPROTEIN
F0


(Human
metapneumovirus)
no annotation 5 ALA F  86
MET F 270
ARG F 129
ALA F 125
VAL F 118
None
1.16A 2qhfA-5wb0F:
undetectable
2qhfA-5wb0F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wou PROTEIN LAP4

(Drosophila
melanogaster)
no annotation 5 ILE A  38
ILE A   7
ALA A  50
ALA A  47
VAL A  41
None
1.08A 2qhfA-5wouA:
undetectable
2qhfA-5wouA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Campylobacter
jejuni)
no annotation 5 THR A 651
ILE A 476
ILE A   9
ALA A 644
VAL A 679
None
1.17A 2qhfA-5x2gA:
undetectable
2qhfA-5x2gA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD


(Deinococcus
radiodurans)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
5 ALA A 693
THR A 697
ILE A 669
ILE A 674
ALA A 746
None
1.15A 2qhfA-5xapA:
undetectable
2qhfA-5xapA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfo PHD FINGER PROTEIN 1

(Homo sapiens)
PF00628
(PHD)
5 THR A 281
ILE A 277
ALA A 308
ALA A 255
VAL A 258
None
1.19A 2qhfA-5xfoA:
undetectable
2qhfA-5xfoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 ANTIBODY FAB HEAVY
CHAIN


(Mus musculus)
no annotation 5 THR A  53
ILE A  51
ALA A  24
ALA A  79
VAL A  72
None
1.10A 2qhfA-6c08A:
undetectable
2qhfA-6c08A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE


(Marinobacter
hydrocarbonoclasticus)
no annotation 5 ALA A 271
ILE A 378
ILE A 329
ALA A 291
VAL A 376
None
1.18A 2qhfA-6chjA:
undetectable
2qhfA-6chjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)


(Homo sapiens)
no annotation 5 MET A  38
ILE A 185
ALA A 357
ALA A 361
VAL A 364
None
0.94A 2qhfA-6fn1A:
undetectable
2qhfA-6fn1A:
undetectable