SIMILAR PATTERNS OF AMINO ACIDS FOR 2QHF_A_ACTA509_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahs AFRICAN HORSE
SICKNESS VIRUS
(SEROTYPE 4) VP7


(African horse
sickness virus)
PF00897
(Orbi_VP7)
3 ARG A 240
GLN A 198
PRO A 197
None
0.85A 2qhfA-1ahsA:
0.2
2qhfA-1ahsA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus)
PF00135
(COesterase)
3 ARG A 247
GLN A 291
PRO A 290
None
0.86A 2qhfA-1c2oA:
0.0
2qhfA-1c2oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli)
PF10412
(TrwB_AAD_bind)
3 ARG A 483
GLN A 109
PRO A 118
None
0.85A 2qhfA-1gl6A:
undetectable
2qhfA-1gl6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpl ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3


(Homo sapiens)
PF00790
(VHS)
3 ARG A  79
GLN A  44
PRO A  43
None
0.80A 2qhfA-1jplA:
undetectable
2qhfA-1jplA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqp DIPEPTIDYL PEPTIDASE
I


(Rattus
norvegicus)
PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc)
3 ARG A 225
GLN A 261
PRO A 260
None
0.91A 2qhfA-1jqpA:
0.0
2qhfA-1jqpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE


(Thermococcus
litoralis)
PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926)
3 ARG A 398
GLN A 516
PRO A 517
None
1.00A 2qhfA-1k1xA:
0.0
2qhfA-1k1xA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3b DIPEPTYDIL-PEPTIDASE
I LIGHT CHAIN


(Homo sapiens)
PF00112
(Peptidase_C1)
3 ARG B 226
GLN B 262
PRO B 261
SO4  B 502 (-3.9A)
None
None
0.98A 2qhfA-1k3bB:
0.0
2qhfA-1k3bB:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvm CATALYTIC DOMAIN OF
THE NUCLEAR
INCLUSION PROTEIN A
(NIA)


(Tobacco etch
virus)
PF00863
(Peptidase_C4)
3 ARG A  86
GLN A  96
PRO A  39
None
0.94A 2qhfA-1lvmA:
0.0
2qhfA-1lvmA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni3 YCHF GTP-BINDING
PROTEIN


(Schizosaccharomyces
pombe)
PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C)
3 ARG A 204
GLN A 201
PRO A 202
None
1.00A 2qhfA-1ni3A:
0.0
2qhfA-1ni3A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 ARG A 130
GLN A 354
PRO A 351
None
0.90A 2qhfA-1pl8A:
0.0
2qhfA-1pl8A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR


(Escherichia
coli)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 ARG A 159
GLN A 176
PRO A 177
None
FLC  A 743 (-3.8A)
None
0.98A 2qhfA-1po0A:
undetectable
2qhfA-1po0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE


(Citrobacter
freundii)
PF02733
(Dak1)
PF02734
(Dak2)
3 ARG A 508
GLN A 482
PRO A 483
None
0.86A 2qhfA-1un9A:
undetectable
2qhfA-1un9A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Enterococcus
faecalis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 ARG A1128
GLN A1159
PRO A1132
None
0.96A 2qhfA-1wueA:
undetectable
2qhfA-1wueA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE


(Ipomoea batatas)
PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N)
3 ARG A 241
GLN A 192
PRO A 193
None
0.96A 2qhfA-1xzwA:
undetectable
2qhfA-1xzwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN


(Pseudomonas
aeruginosa)
PF01522
(Polysacc_deac_1)
3 ARG A  41
GLN A  61
PRO A  62
None
0.93A 2qhfA-1z7aA:
undetectable
2qhfA-1z7aA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1


(Homo sapiens)
PF00330
(Aconitase)
PF00694
(Aconitase_C)
3 ARG A 536
GLN A 377
PRO A 376
None
0.71A 2qhfA-2b3xA:
undetectable
2qhfA-2b3xA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MAJOR PLASMODIAL
MYOSIN HEAVY CHAIN
MYOSIN REGULATORY
LIGHT CHAIN


(Physarum
polycephalum;
Physarum
polycephalum)
PF00612
(IQ)
PF00036
(EF-hand_1)
PF13499
(EF-hand_7)
3 ARG A 797
GLN B  74
PRO B  71
None
0.57A 2qhfA-2bl0A:
undetectable
2qhfA-2bl0A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Sulfurisphaera
tokodaii)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 ARG A 331
GLN A 273
PRO A 281
None
0.75A 2qhfA-2ep5A:
undetectable
2qhfA-2ep5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyx V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG ISOFORM A


(Homo sapiens)
PF07653
(SH3_2)
3 ARG A 246
GLN A 274
PRO A 287
None
0.73A 2qhfA-2eyxA:
undetectable
2qhfA-2eyxA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7e ENDONUCLEASE I

(Vibrio cholerae)
PF04231
(Endonuclease_1)
3 ARG A 130
GLN A  86
PRO A  83
None
0.61A 2qhfA-2g7eA:
undetectable
2qhfA-2g7eA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE


(Desulfovibrio
desulfuricans)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
3 ARG A  14
GLN A 346
PRO A 347
MGD  A 811 (-4.2A)
CYN  A 813 (-4.0A)
None
0.99A 2qhfA-2jirA:
undetectable
2qhfA-2jirA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kks UNCHARACTERIZED
PROTEIN


(Desulfitobacterium
hafniense)
PF14464
(Prok-JAB)
3 ARG A  17
GLN A 114
PRO A 113
None
0.98A 2qhfA-2kksA:
undetectable
2qhfA-2kksA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE


(Homo sapiens)
PF01432
(Peptidase_M3)
3 ARG A 333
GLN A 581
PRO A 587
None
1.01A 2qhfA-2o36A:
undetectable
2qhfA-2o36A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10


(Homo sapiens)
PF00581
(Rhodanese)
3 ARG A 202
GLN A 250
PRO A 251
None
0.97A 2qhfA-2oucA:
undetectable
2qhfA-2oucA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pu3 ENDONUCLEASE I

(Aliivibrio
salmonicida)
PF04231
(Endonuclease_1)
3 ARG A 130
GLN A  86
PRO A  83
None
CL  A 302 (-3.9A)
None
0.77A 2qhfA-2pu3A:
undetectable
2qhfA-2pu3A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE


(Sapporo virus)
PF00680
(RdRP_1)
3 ARG A 295
GLN A   4
PRO A   9
None
0.97A 2qhfA-2uutA:
undetectable
2qhfA-2uutA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtc CEL61B

(Trichoderma
reesei)
PF03443
(Glyco_hydro_61)
3 ARG A 114
GLN A 200
PRO A 197
None
0.99A 2qhfA-2vtcA:
undetectable
2qhfA-2vtcA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xri ERI1 EXORIBONUCLEASE
3


(Homo sapiens)
PF00929
(RNase_T)
3 ARG A 223
GLN A 214
PRO A 215
None
0.86A 2qhfA-2xriA:
undetectable
2qhfA-2xriA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE


(Infectious
pancreatic
necrosis virus)
PF04197
(Birna_RdRp)
3 ARG A 786
GLN A 413
PRO A 412
None
0.96A 2qhfA-2yiaA:
undetectable
2qhfA-2yiaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens)
PF01522
(Polysacc_deac_1)
3 ARG A  41
GLN A  61
PRO A  62
None
0.93A 2qhfA-3cl6A:
undetectable
2qhfA-3cl6A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv9 BETA-PHOSPHOGLUCOMUT
ASE


(Bacteroides
vulgatus)
PF13419
(HAD_2)
3 ARG A  64
GLN A 193
PRO A 163
None
0.95A 2qhfA-3dv9A:
undetectable
2qhfA-3dv9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
3 ARG A 485
GLN A 423
PRO A 456
None
0.87A 2qhfA-3egwA:
undetectable
2qhfA-3egwA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
3 ARG A 295
GLN A 225
PRO A 221
None
0.58A 2qhfA-3fe3A:
undetectable
2qhfA-3fe3A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg9 PROTEIN OF UNIVERSAL
STRESS PROTEIN USPA
FAMILY


(Lactobacillus
plantarum)
PF00582
(Usp)
3 ARG A  14
GLN A  92
PRO A  44
MG  A 154 ( 4.3A)
None
None
0.85A 2qhfA-3fg9A:
undetectable
2qhfA-3fg9A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE


(Bordetella
bronchiseptica)
PF07969
(Amidohydro_3)
3 ARG A  80
GLN A 465
PRO A 466
None
0.90A 2qhfA-3gipA:
undetectable
2qhfA-3gipA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR


(Chromobacterium
violaceum)
PF13377
(Peripla_BP_3)
3 ARG A 337
GLN A 267
PRO A 293
None
0.97A 2qhfA-3h5oA:
undetectable
2qhfA-3h5oA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
3 ARG A 292
GLN A 222
PRO A 218
None
0.87A 2qhfA-3iecA:
undetectable
2qhfA-3iecA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN


(Escherichia
coli)
PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C)
3 ARG B 655
GLN B 695
PRO B 659
None
0.72A 2qhfA-3k70B:
undetectable
2qhfA-3k70B:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE


(Listeria
monocytogenes)
PF00563
(EAL)
3 ARG A  29
GLN A  11
PRO A 232
None
1.00A 2qhfA-3kzpA:
undetectable
2qhfA-3kzpA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9k RE64145P

(Drosophila
melanogaster)
PF03259
(Robl_LC7)
3 ARG A  73
GLN A  93
PRO A  95
None
0.83A 2qhfA-3l9kA:
undetectable
2qhfA-3l9kA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1g BROTHER OF CDO

(Homo sapiens)
PF00041
(fn3)
3 ARG C 812
GLN C 781
PRO C 782
None
0.83A 2qhfA-3n1gC:
undetectable
2qhfA-3n1gC:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE


(Archaeoglobus
fulgidus)
PF03587
(EMG1)
3 ARG A  59
GLN A  17
PRO A  16
None
0.81A 2qhfA-3o7bA:
undetectable
2qhfA-3o7bA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE


(Salmonella
enterica)
PF00285
(Citrate_synt)
3 ARG A  94
GLN A 161
PRO A 162
None
0.93A 2qhfA-3o8jA:
undetectable
2qhfA-3o8jA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyn PFV INTEGRASE

(Simian foamy
virus)
PF00665
(rve)
3 ARG A 362
GLN A 186
PRO A 211
None
0.93A 2qhfA-3oynA:
undetectable
2qhfA-3oynA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdf DIPEPTIDYL PEPTIDASE
1


(Homo sapiens)
PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc)
3 ARG A 226
GLN A 262
PRO A 261
None
0.97A 2qhfA-3pdfA:
undetectable
2qhfA-3pdfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
3 ARG A 492
GLN A 501
PRO A 498
None
0.87A 2qhfA-3u4aA:
undetectable
2qhfA-3u4aA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A


(Acinetobacter
baumannii)
PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB)
3 ARG A 430
GLN A 698
PRO A 699
None
1.01A 2qhfA-3ue1A:
2.3
2qhfA-3ue1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT


(Geobacillus sp.
Y412MC52)
PF00005
(ABC_tran)
3 ARG A 766
GLN A 821
PRO A 822
None
0.99A 2qhfA-3ux8A:
undetectable
2qhfA-3ux8A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE


(Aeropyrum
pernix)
PF01266
(DAO)
3 ARG A  46
GLN A 318
PRO A 317
None
0.87A 2qhfA-3vqrA:
undetectable
2qhfA-3vqrA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0s HYGROMYCIN-B
4-O-KINASE


(Escherichia
coli)
PF01636
(APH)
3 ARG A 210
GLN A 113
PRO A 114
None
0.77A 2qhfA-3w0sA:
undetectable
2qhfA-3w0sA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2


(Pyrococcus
furiosus)
PF12469
(DUF3692)
3 ARG A 658
GLN A 277
PRO A 278
None
0.95A 2qhfA-3x1lA:
undetectable
2qhfA-3x1lA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Flaveria
pringlei)
PF00311
(PEPcase)
3 ARG A 293
GLN A 233
PRO A 232
None
0.79A 2qhfA-3zgbA:
undetectable
2qhfA-3zgbA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD


(Acinetobacter
baumannii)
PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C)
3 ARG A  61
GLN A  52
PRO A  53
None
0.91A 2qhfA-3zpcA:
undetectable
2qhfA-3zpcA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE


(Pyrococcus
furiosus)
PF00697
(PRAI)
3 ARG A 124
GLN A  85
PRO A  84
None
0.95A 2qhfA-4aajA:
undetectable
2qhfA-4aajA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3g DNA-BINDING PROTEIN
SMUBP-2


(Homo sapiens)
PF13086
(AAA_11)
PF13087
(AAA_12)
3 ARG A 443
GLN A 403
PRO A 216
None
0.99A 2qhfA-4b3gA:
undetectable
2qhfA-4b3gA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9a PROBABLE EPOXIDE
HYDROLASE


(Pseudomonas
aeruginosa)
PF00561
(Abhydrolase_1)
3 ARG A 233
GLN A 122
PRO A 121
None
SO4  A1305 (-3.5A)
SO4  A1305 (-3.2A)
1.00A 2qhfA-4b9aA:
undetectable
2qhfA-4b9aA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cta CINA-LIKE PROTEIN

(Thermus
thermophilus)
PF00994
(MoCF_biosynth)
PF02464
(CinA)
3 ARG A 132
GLN A 162
PRO A 159
None
0.96A 2qhfA-4ctaA:
undetectable
2qhfA-4ctaA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE


(Sulfurisphaera
tokodaii)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 ARG A 338
GLN A 277
PRO A 285
None
0.81A 2qhfA-4dpkA:
undetectable
2qhfA-4dpkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxw ION TRANSPORT
PROTEIN


(alpha
proteobacterium
HIMB114)
PF00520
(Ion_trans)
3 ARG A  12
GLN A 121
PRO A 117
None
0.92A 2qhfA-4dxwA:
undetectable
2qhfA-4dxwA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN


(Bacteroides
thetaiotaomicron)
PF14660
(DUF4458)
3 ARG A 821
GLN A 892
PRO A 866
None
0.95A 2qhfA-4ecnA:
undetectable
2qhfA-4ecnA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN


(Bacteroides
eggerthii)
no annotation 3 ARG A 821
GLN A 892
PRO A 866
None
0.98A 2qhfA-4ecoA:
undetectable
2qhfA-4ecoA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN


(Arabidopsis
thaliana)
PF00225
(Kinesin)
3 ARG A 897
GLN A 910
PRO A1189
None
0.96A 2qhfA-4frzA:
undetectable
2qhfA-4frzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN


(Sindbis virus)
PF01661
(Macro)
PF01707
(Peptidase_C9)
3 ARG A1239
GLN A1048
PRO A1047
None
0.94A 2qhfA-4guaA:
undetectable
2qhfA-4guaA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans)
PF00232
(Glyco_hydro_1)
3 ARG A 352
GLN A 406
PRO A 363
None
0.79A 2qhfA-4ha4A:
undetectable
2qhfA-4ha4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iws PA0254

(Pseudomonas
aeruginosa)
PF01977
(UbiD)
3 ARG A 193
GLN A 290
PRO A 291
None
0.87A 2qhfA-4iwsA:
undetectable
2qhfA-4iwsA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8b COATOMER ALPHA
SUBUNIT


(Schizosaccharomyces
pombe)
PF00400
(WD40)
3 ARG A  41
GLN A  23
PRO A  24
None
0.50A 2qhfA-4j8bA:
undetectable
2qhfA-4j8bA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyk HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RUTR


(Escherichia
coli)
PF00440
(TetR_N)
PF08362
(TetR_C_3)
3 ARG A 189
GLN A 110
PRO A 109
None
0.95A 2qhfA-4jykA:
undetectable
2qhfA-4jykA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana)
PF01432
(Peptidase_M3)
3 ARG A 490
GLN A 550
PRO A 509
None
0.90A 2qhfA-4ka8A:
undetectable
2qhfA-4ka8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]


(Synechocystis
sp. PCC 6803)
PF02347
(GDC-P)
3 ARG A 433
GLN A 200
PRO A 199
None
1.01A 2qhfA-4lglA:
undetectable
2qhfA-4lglA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE


(Mycobacterium
avium)
PF00479
(G6PD_N)
PF02781
(G6PD_C)
3 ARG A 317
GLN A 458
PRO A 459
None
0.89A 2qhfA-4lgvA:
undetectable
2qhfA-4lgvA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oem DIPEPTIDYL PEPTIDASE
1 HEAVY CHAIN


(Homo sapiens)
PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc)
3 ARG A 226
GLN A 262
PRO A 261
None
0.91A 2qhfA-4oemA:
undetectable
2qhfA-4oemA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3


(Thermobaculum
terrenum)
PF00271
(Helicase_C)
3 ARG A 890
GLN A 604
PRO A 601
None
0.70A 2qhfA-4q2cA:
undetectable
2qhfA-4q2cA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27


(Chaetomium
thermophilum)
PF00160
(Pro_isomerase)
3 ARG A 158
GLN A  10
PRO A  11
None
0.90A 2qhfA-4r3fA:
undetectable
2qhfA-4r3fA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN


(Nitratireductor
pacificus)
PF12838
(Fer4_7)
PF13486
(Dehalogenase)
3 ARG A 287
GLN A 658
PRO A 659
None
0.85A 2qhfA-4rasA:
undetectable
2qhfA-4rasA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE


(Thermus
thermophilus)
PF00588
(SpoU_methylase)
3 ARG A  23
GLN A 150
PRO A 149
None
1.00A 2qhfA-4x3mA:
undetectable
2qhfA-4x3mA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE


(Chlamydomonas
reinhardtii)
PF00194
(Carb_anhydrase)
3 ARG A 173
GLN A 299
PRO A  98
None
0.99A 2qhfA-4xixA:
undetectable
2qhfA-4xixA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1)
3 ARG A 403
GLN A 395
PRO A 396
None
1.00A 2qhfA-4ydqA:
undetectable
2qhfA-4ydqA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
3 ARG A 276
GLN A 294
PRO A 293
None
0.93A 2qhfA-4zzhA:
undetectable
2qhfA-4zzhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis)
no annotation 3 ARG A 304
GLN A 517
PRO A 397
None
0.66A 2qhfA-5awpA:
undetectable
2qhfA-5awpA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Pseudomonas
aeruginosa)
PF00275
(EPSP_synthase)
3 ARG A 155
GLN A 137
PRO A 150
None
0.73A 2qhfA-5bq2A:
undetectable
2qhfA-5bq2A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli)
PF01212
(Beta_elim_lyase)
3 ARG A 241
GLN A 203
PRO A 204
None
0.97A 2qhfA-5d8gA:
undetectable
2qhfA-5d8gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus)
PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N)
3 ARG A 206
GLN A 226
PRO A 221
None
0.89A 2qhfA-5df0A:
undetectable
2qhfA-5df0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80


(Murine leukemia
virus)
PF00075
(RNase_H)
PF00078
(RVT_1)
3 ARG A 585
GLN A 639
PRO A 636
None
0.95A 2qhfA-5dmqA:
undetectable
2qhfA-5dmqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP46
EXOSOME COMPLEX
COMPONENT CSL4


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF10447
(EXOSC1)
3 ARG I 142
GLN D  45
PRO D  43
None
1.00A 2qhfA-5g06I:
undetectable
2qhfA-5g06I:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis)
PF13354
(Beta-lactamase2)
3 ARG A 165
GLN A 146
PRO A 145
None
0.85A 2qhfA-5gl9A:
undetectable
2qhfA-5gl9A:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC


(Zea mays)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
3 ARG A 321
GLN A 504
PRO A 541
None
0.88A 2qhfA-5h8yA:
undetectable
2qhfA-5h8yA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibk POLYUBIQUITIN-B

(Homo sapiens)
no annotation 3 ARG F  74
GLN F  31
PRO F  37
None
0.89A 2qhfA-5ibkF:
undetectable
2qhfA-5ibkF:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)


(Oryctolagus
cuniculus)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
3 ARG S 398
GLN S 219
PRO S 179
None
0.85A 2qhfA-5k0yS:
undetectable
2qhfA-5k0yS:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0l UNCHARACTERIZED
PROTEIN


(Legionella
pneumophila)
no annotation 3 ARG A 227
GLN A 262
PRO A 243
None
0.96A 2qhfA-5l0lA:
undetectable
2qhfA-5l0lA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425)
PF00881
(Nitroreductase)
3 ARG A 323
GLN A 354
PRO A 355
None
0.99A 2qhfA-5lq4A:
undetectable
2qhfA-5lq4A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE


(Pseudomonas
aeruginosa)
PF00563
(EAL)
3 ARG A 473
GLN A 455
PRO A 674
C2E  A 701 (-2.4A)
C2E  A 701 (-3.0A)
C2E  A 701 (-4.7A)
1.01A 2qhfA-5m1tA:
undetectable
2qhfA-5m1tA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL


(Homo sapiens)
PF01161
(PBP)
3 ARG 6 364
GLN 6 361
PRO 6 362
A  A2858 ( 3.5A)
None
None
0.99A 2qhfA-5ool6:
undetectable
2qhfA-5ool6:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN


(Escherichia
coli;
Danio rerio)
PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8)
3 ARG A  66
GLN A1345
PRO A  48
GLC  A1410 (-3.8A)
None
None
0.96A 2qhfA-5t03A:
undetectable
2qhfA-5t03A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN


(Bacteroides
intestinalis)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
3 ARG A 529
GLN A 538
PRO A 535
None
0.89A 2qhfA-5tf0A:
undetectable
2qhfA-5tf0A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens)
no annotation 3 ARG A 460
GLN A 496
PRO A 458
None
0.95A 2qhfA-5weaA:
undetectable
2qhfA-5weaA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjs GEM-ASSOCIATED
PROTEIN 2


(Homo sapiens)
no annotation 3 ARG 2 245
GLN 2 103
PRO 2  98
None
0.98A 2qhfA-5xjs2:
undetectable
2qhfA-5xjs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE


(Bacteroides
thetaiotaomicron)
no annotation 3 ARG A 527
GLN A 536
PRO A 533
None
0.84A 2qhfA-5xxoA:
undetectable
2qhfA-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii)
PF06427
(UDP-g_GGTase)
3 ARG A 811
GLN A 663
PRO A 662
None
0.97A 2qhfA-5y7oA:
undetectable
2qhfA-5y7oA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc0 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4G


(Chaetomium
thermophilum)
no annotation 3 ARG B 963
GLN B 954
PRO B 955
None
0.72A 2qhfA-6fc0B:
undetectable
2qhfA-6fc0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gi2 FERRIC ENTEROBACTIN
ESTERASE


(Pseudomonas
aeruginosa)
no annotation 3 ARG A 150
GLN A  45
PRO A  48
None
0.98A 2qhfA-6gi2A:
undetectable
2qhfA-6gi2A:
undetectable