SIMILAR PATTERNS OF AMINO ACIDS FOR 2QHF_A_ACTA509_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ahs | AFRICAN HORSESICKNESS VIRUS(SEROTYPE 4) VP7 (African horsesickness virus) |
PF00897(Orbi_VP7) | 3 | ARG A 240GLN A 198PRO A 197 | None | 0.85A | 2qhfA-1ahsA:0.2 | 2qhfA-1ahsA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c2o | ACETYLCHOLINESTERASE (Electrophoruselectricus) |
PF00135(COesterase) | 3 | ARG A 247GLN A 291PRO A 290 | None | 0.86A | 2qhfA-1c2oA:0.0 | 2qhfA-1c2oA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gl6 | ATPASE (Escherichiacoli) |
PF10412(TrwB_AAD_bind) | 3 | ARG A 483GLN A 109PRO A 118 | None | 0.85A | 2qhfA-1gl6A:undetectable | 2qhfA-1gl6A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jpl | ADP-RIBOSYLATIONFACTOR BINDINGPROTEIN GGA3 (Homo sapiens) |
PF00790(VHS) | 3 | ARG A 79GLN A 44PRO A 43 | None | 0.80A | 2qhfA-1jplA:undetectable | 2qhfA-1jplA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqp | DIPEPTIDYL PEPTIDASEI (Rattusnorvegicus) |
PF00112(Peptidase_C1)PF08773(CathepsinC_exc) | 3 | ARG A 225GLN A 261PRO A 260 | None | 0.91A | 2qhfA-1jqpA:0.0 | 2qhfA-1jqpA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k1x | 4-ALPHA-GLUCANOTRANSFERASE (Thermococcuslitoralis) |
PF03065(Glyco_hydro_57)PF09094(DUF1925)PF09095(DUF1926) | 3 | ARG A 398GLN A 516PRO A 517 | None | 1.00A | 2qhfA-1k1xA:0.0 | 2qhfA-1k1xA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k3b | DIPEPTYDIL-PEPTIDASEI LIGHT CHAIN (Homo sapiens) |
PF00112(Peptidase_C1) | 3 | ARG B 226GLN B 262PRO B 261 | SO4 B 502 (-3.9A)NoneNone | 0.98A | 2qhfA-1k3bB:0.0 | 2qhfA-1k3bB:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lvm | CATALYTIC DOMAIN OFTHE NUCLEARINCLUSION PROTEIN A(NIA) (Tobacco etchvirus) |
PF00863(Peptidase_C4) | 3 | ARG A 86GLN A 96PRO A 39 | None | 0.94A | 2qhfA-1lvmA:0.0 | 2qhfA-1lvmA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ni3 | YCHF GTP-BINDINGPROTEIN (Schizosaccharomycespombe) |
PF01926(MMR_HSR1)PF06071(YchF-GTPase_C) | 3 | ARG A 204GLN A 201PRO A 202 | None | 1.00A | 2qhfA-1ni3A:0.0 | 2qhfA-1ni3A:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl8 | HUMAN SORBITOLDEHYDROGENASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | ARG A 130GLN A 354PRO A 351 | None | 0.90A | 2qhfA-1pl8A:0.0 | 2qhfA-1pl8A:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1po0 | IRON(III) DICITRATETRANSPORT PROTEINFECA PRECURSOR (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | ARG A 159GLN A 176PRO A 177 | NoneFLC A 743 (-3.8A)None | 0.98A | 2qhfA-1po0A:undetectable | 2qhfA-1po0A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1un9 | DIHYDROXYACETONEKINASE (Citrobacterfreundii) |
PF02733(Dak1)PF02734(Dak2) | 3 | ARG A 508GLN A 482PRO A 483 | None | 0.86A | 2qhfA-1un9A:undetectable | 2qhfA-1un9A:24.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wue | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Enterococcusfaecalis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | ARG A1128GLN A1159PRO A1132 | None | 0.96A | 2qhfA-1wueA:undetectable | 2qhfA-1wueA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xzw | PURPLE ACIDPHOSPHATASE (Ipomoea batatas) |
PF00149(Metallophos)PF14008(Metallophos_C)PF16656(Pur_ac_phosph_N) | 3 | ARG A 241GLN A 192PRO A 193 | None | 0.96A | 2qhfA-1xzwA:undetectable | 2qhfA-1xzwA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7a | CONSERVEDHYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF01522(Polysacc_deac_1) | 3 | ARG A 41GLN A 61PRO A 62 | None | 0.93A | 2qhfA-1z7aA:undetectable | 2qhfA-1z7aA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3x | IRON-RESPONSIVEELEMENT BINDINGPROTEIN 1 (Homo sapiens) |
PF00330(Aconitase)PF00694(Aconitase_C) | 3 | ARG A 536GLN A 377PRO A 376 | None | 0.71A | 2qhfA-2b3xA:undetectable | 2qhfA-2b3xA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bl0 | MAJOR PLASMODIALMYOSIN HEAVY CHAINMYOSIN REGULATORYLIGHT CHAIN (Physarumpolycephalum;Physarumpolycephalum) |
PF00612(IQ)PF00036(EF-hand_1)PF13499(EF-hand_7) | 3 | ARG A 797GLN B 74PRO B 71 | None | 0.57A | 2qhfA-2bl0A:undetectable | 2qhfA-2bl0A:10.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ep5 | 350AA LONGHYPOTHETICALASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Sulfurisphaeratokodaii) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | ARG A 331GLN A 273PRO A 281 | None | 0.75A | 2qhfA-2ep5A:undetectable | 2qhfA-2ep5A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eyx | V-CRK SARCOMA VIRUSCT10 ONCOGENEHOMOLOG ISOFORM A (Homo sapiens) |
PF07653(SH3_2) | 3 | ARG A 246GLN A 274PRO A 287 | None | 0.73A | 2qhfA-2eyxA:undetectable | 2qhfA-2eyxA:10.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g7e | ENDONUCLEASE I (Vibrio cholerae) |
PF04231(Endonuclease_1) | 3 | ARG A 130GLN A 86PRO A 83 | None | 0.61A | 2qhfA-2g7eA:undetectable | 2qhfA-2g7eA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jir | PERIPLASMIC NITRATEREDUCTASE (Desulfovibriodesulfuricans) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 3 | ARG A 14GLN A 346PRO A 347 | MGD A 811 (-4.2A)CYN A 813 (-4.0A)None | 0.99A | 2qhfA-2jirA:undetectable | 2qhfA-2jirA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kks | UNCHARACTERIZEDPROTEIN (Desulfitobacteriumhafniense) |
PF14464(Prok-JAB) | 3 | ARG A 17GLN A 114PRO A 113 | None | 0.98A | 2qhfA-2kksA:undetectable | 2qhfA-2kksA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o36 | THIMETOLIGOPEPTIDASE (Homo sapiens) |
PF01432(Peptidase_M3) | 3 | ARG A 333GLN A 581PRO A 587 | None | 1.01A | 2qhfA-2o36A:undetectable | 2qhfA-2o36A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ouc | DUAL SPECIFICITYPROTEIN PHOSPHATASE10 (Homo sapiens) |
PF00581(Rhodanese) | 3 | ARG A 202GLN A 250PRO A 251 | None | 0.97A | 2qhfA-2oucA:undetectable | 2qhfA-2oucA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pu3 | ENDONUCLEASE I (Aliivibriosalmonicida) |
PF04231(Endonuclease_1) | 3 | ARG A 130GLN A 86PRO A 83 | None CL A 302 (-3.9A)None | 0.77A | 2qhfA-2pu3A:undetectable | 2qhfA-2pu3A:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uut | RNA-DIRECTED RNAPOLYMERASE (Sapporo virus) |
PF00680(RdRP_1) | 3 | ARG A 295GLN A 4PRO A 9 | None | 0.97A | 2qhfA-2uutA:undetectable | 2qhfA-2uutA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vtc | CEL61B (Trichodermareesei) |
PF03443(Glyco_hydro_61) | 3 | ARG A 114GLN A 200PRO A 197 | None | 0.99A | 2qhfA-2vtcA:undetectable | 2qhfA-2vtcA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xri | ERI1 EXORIBONUCLEASE3 (Homo sapiens) |
PF00929(RNase_T) | 3 | ARG A 223GLN A 214PRO A 215 | None | 0.86A | 2qhfA-2xriA:undetectable | 2qhfA-2xriA:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yia | RNA-DIRECTED RNAPOLYMERASE (Infectiouspancreaticnecrosis virus) |
PF04197(Birna_RdRp) | 3 | ARG A 786GLN A 413PRO A 412 | None | 0.96A | 2qhfA-2yiaA:undetectable | 2qhfA-2yiaA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cl6 | PUUE ALLANTOINASE (Pseudomonasfluorescens) |
PF01522(Polysacc_deac_1) | 3 | ARG A 41GLN A 61PRO A 62 | None | 0.93A | 2qhfA-3cl6A:undetectable | 2qhfA-3cl6A:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dv9 | BETA-PHOSPHOGLUCOMUTASE (Bacteroidesvulgatus) |
PF13419(HAD_2) | 3 | ARG A 64GLN A 193PRO A 163 | None | 0.95A | 2qhfA-3dv9A:undetectable | 2qhfA-3dv9A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 ALPHACHAIN (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF14710(Nitr_red_alph_N) | 3 | ARG A 485GLN A 423PRO A 456 | None | 0.87A | 2qhfA-3egwA:undetectable | 2qhfA-3egwA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fe3 | MAP/MICROTUBULEAFFINITY-REGULATINGKINASE 3 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 3 | ARG A 295GLN A 225PRO A 221 | None | 0.58A | 2qhfA-3fe3A:undetectable | 2qhfA-3fe3A:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg9 | PROTEIN OF UNIVERSALSTRESS PROTEIN USPAFAMILY (Lactobacillusplantarum) |
PF00582(Usp) | 3 | ARG A 14GLN A 92PRO A 44 | MG A 154 ( 4.3A)NoneNone | 0.85A | 2qhfA-3fg9A:undetectable | 2qhfA-3fg9A:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gip | N-ACYL-D-GLUTAMATEDEACYLASE (Bordetellabronchiseptica) |
PF07969(Amidohydro_3) | 3 | ARG A 80GLN A 465PRO A 466 | None | 0.90A | 2qhfA-3gipA:undetectable | 2qhfA-3gipA:25.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5o | TRANSCRIPTIONALREGULATOR GNTR (Chromobacteriumviolaceum) |
PF13377(Peripla_BP_3) | 3 | ARG A 337GLN A 267PRO A 293 | None | 0.97A | 2qhfA-3h5oA:undetectable | 2qhfA-3h5oA:26.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iec | SERINE/THREONINE-PROTEIN KINASE MARK2 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 3 | ARG A 292GLN A 222PRO A 218 | None | 0.87A | 2qhfA-3iecA:undetectable | 2qhfA-3iecA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k70 | EXODEOXYRIBONUCLEASEV BETA CHAIN (Escherichiacoli) |
PF00580(UvrD-helicase)PF12705(PDDEXK_1)PF13361(UvrD_C) | 3 | ARG B 655GLN B 695PRO B 659 | None | 0.72A | 2qhfA-3k70B:undetectable | 2qhfA-3k70B:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzp | PUTATIVE DIGUANYLATECYCLASE/PHOSPHODIESTERASE (Listeriamonocytogenes) |
PF00563(EAL) | 3 | ARG A 29GLN A 11PRO A 232 | None | 1.00A | 2qhfA-3kzpA:undetectable | 2qhfA-3kzpA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l9k | RE64145P (Drosophilamelanogaster) |
PF03259(Robl_LC7) | 3 | ARG A 73GLN A 93PRO A 95 | None | 0.83A | 2qhfA-3l9kA:undetectable | 2qhfA-3l9kA:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n1g | BROTHER OF CDO (Homo sapiens) |
PF00041(fn3) | 3 | ARG C 812GLN C 781PRO C 782 | None | 0.83A | 2qhfA-3n1gC:undetectable | 2qhfA-3n1gC:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o7b | RIBOSOME BIOGENESISNEP1 RNAMETHYLTRANSFERASE (Archaeoglobusfulgidus) |
PF03587(EMG1) | 3 | ARG A 59GLN A 17PRO A 16 | None | 0.81A | 2qhfA-3o7bA:undetectable | 2qhfA-3o7bA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8j | 2-METHYLCITRATESYNTHASE (Salmonellaenterica) |
PF00285(Citrate_synt) | 3 | ARG A 94GLN A 161PRO A 162 | None | 0.93A | 2qhfA-3o8jA:undetectable | 2qhfA-3o8jA:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oyn | PFV INTEGRASE (Simian foamyvirus) |
PF00665(rve) | 3 | ARG A 362GLN A 186PRO A 211 | None | 0.93A | 2qhfA-3oynA:undetectable | 2qhfA-3oynA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pdf | DIPEPTIDYL PEPTIDASE1 (Homo sapiens) |
PF00112(Peptidase_C1)PF08773(CathepsinC_exc) | 3 | ARG A 226GLN A 262PRO A 261 | None | 0.97A | 2qhfA-3pdfA:undetectable | 2qhfA-3pdfA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4a | JMB19063 (compostmetagenome) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 3 | ARG A 492GLN A 501PRO A 498 | None | 0.87A | 2qhfA-3u4aA:undetectable | 2qhfA-3u4aA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ue1 | PENICILLIN-BINDINGPROTEIN 1A (Acinetobacterbaumannii) |
PF00905(Transpeptidase)PF00912(Transgly)PF17092(PCB_OB) | 3 | ARG A 430GLN A 698PRO A 699 | None | 1.01A | 2qhfA-3ue1A:2.3 | 2qhfA-3ue1A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ux8 | EXCINUCLEASE ABC, ASUBUNIT (Geobacillus sp.Y412MC52) |
PF00005(ABC_tran) | 3 | ARG A 766GLN A 821PRO A 822 | None | 0.99A | 2qhfA-3ux8A:undetectable | 2qhfA-3ux8A:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vqr | PUTATIVEOXIDOREDUCTASE (Aeropyrumpernix) |
PF01266(DAO) | 3 | ARG A 46GLN A 318PRO A 317 | None | 0.87A | 2qhfA-3vqrA:undetectable | 2qhfA-3vqrA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w0s | HYGROMYCIN-B4-O-KINASE (Escherichiacoli) |
PF01636(APH) | 3 | ARG A 210GLN A 113PRO A 114 | None | 0.77A | 2qhfA-3w0sA:undetectable | 2qhfA-3w0sA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x1l | CRISPR SYSTEM CMRSUBUNIT CMR2 (Pyrococcusfuriosus) |
PF12469(DUF3692) | 3 | ARG A 658GLN A 277PRO A 278 | None | 0.95A | 2qhfA-3x1lA:undetectable | 2qhfA-3x1lA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zgb | PHOSPHOENOLPYRUVATECARBOXYLASE (Flaveriapringlei) |
PF00311(PEPcase) | 3 | ARG A 293GLN A 233PRO A 232 | None | 0.79A | 2qhfA-3zgbA:undetectable | 2qhfA-3zgbA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zpc | RIBOFLAVINBIOSYNTHESIS PROTEINRIBD (Acinetobacterbaumannii) |
PF00383(dCMP_cyt_deam_1)PF01872(RibD_C) | 3 | ARG A 61GLN A 52PRO A 53 | None | 0.91A | 2qhfA-3zpcA:undetectable | 2qhfA-3zpcA:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aaj | N-(5'-PHOSPHORIBOSYL)ANTHRANILATEISOMERASE (Pyrococcusfuriosus) |
PF00697(PRAI) | 3 | ARG A 124GLN A 85PRO A 84 | None | 0.95A | 2qhfA-4aajA:undetectable | 2qhfA-4aajA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3g | DNA-BINDING PROTEINSMUBP-2 (Homo sapiens) |
PF13086(AAA_11)PF13087(AAA_12) | 3 | ARG A 443GLN A 403PRO A 216 | None | 0.99A | 2qhfA-4b3gA:undetectable | 2qhfA-4b3gA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b9a | PROBABLE EPOXIDEHYDROLASE (Pseudomonasaeruginosa) |
PF00561(Abhydrolase_1) | 3 | ARG A 233GLN A 122PRO A 121 | NoneSO4 A1305 (-3.5A)SO4 A1305 (-3.2A) | 1.00A | 2qhfA-4b9aA:undetectable | 2qhfA-4b9aA:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cta | CINA-LIKE PROTEIN (Thermusthermophilus) |
PF00994(MoCF_biosynth)PF02464(CinA) | 3 | ARG A 132GLN A 162PRO A 159 | None | 0.96A | 2qhfA-4ctaA:undetectable | 2qhfA-4ctaA:26.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dpk | MALONYL-COA/SUCCINYL-COA REDUCTASE (Sulfurisphaeratokodaii) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | ARG A 338GLN A 277PRO A 285 | None | 0.81A | 2qhfA-4dpkA:undetectable | 2qhfA-4dpkA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dxw | ION TRANSPORTPROTEIN (alphaproteobacteriumHIMB114) |
PF00520(Ion_trans) | 3 | ARG A 12GLN A 121PRO A 117 | None | 0.92A | 2qhfA-4dxwA:undetectable | 2qhfA-4dxwA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecn | LEUCINE-RICH REPEATPROTEIN (Bacteroidesthetaiotaomicron) |
PF14660(DUF4458) | 3 | ARG A 821GLN A 892PRO A 866 | None | 0.95A | 2qhfA-4ecnA:undetectable | 2qhfA-4ecnA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eco | UNCHARACTERIZEDPROTEIN (Bacteroideseggerthii) |
no annotation | 3 | ARG A 821GLN A 892PRO A 866 | None | 0.98A | 2qhfA-4ecoA:undetectable | 2qhfA-4ecoA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4frz | KINESIN-LIKECALMODULIN-BINDINGPROTEIN (Arabidopsisthaliana) |
PF00225(Kinesin) | 3 | ARG A 897GLN A 910PRO A1189 | None | 0.96A | 2qhfA-4frzA:undetectable | 2qhfA-4frzA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gua | NON-STRUCTURALPOLYPROTEIN (Sindbis virus) |
PF01661(Macro)PF01707(Peptidase_C9) | 3 | ARG A1239GLN A1048PRO A1047 | None | 0.94A | 2qhfA-4guaA:undetectable | 2qhfA-4guaA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ha4 | BETA-GALACTOSIDASE (Acidilobussaccharovorans) |
PF00232(Glyco_hydro_1) | 3 | ARG A 352GLN A 406PRO A 363 | None | 0.79A | 2qhfA-4ha4A:undetectable | 2qhfA-4ha4A:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iws | PA0254 (Pseudomonasaeruginosa) |
PF01977(UbiD) | 3 | ARG A 193GLN A 290PRO A 291 | None | 0.87A | 2qhfA-4iwsA:undetectable | 2qhfA-4iwsA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j8b | COATOMER ALPHASUBUNIT (Schizosaccharomycespombe) |
PF00400(WD40) | 3 | ARG A 41GLN A 23PRO A 24 | None | 0.50A | 2qhfA-4j8bA:undetectable | 2qhfA-4j8bA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jyk | HTH-TYPETRANSCRIPTIONALREGULATOR RUTR (Escherichiacoli) |
PF00440(TetR_N)PF08362(TetR_C_3) | 3 | ARG A 189GLN A 110PRO A 109 | None | 0.95A | 2qhfA-4jykA:undetectable | 2qhfA-4jykA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ka8 | OLIGOPEPTIDASE A (Arabidopsisthaliana) |
PF01432(Peptidase_M3) | 3 | ARG A 490GLN A 550PRO A 509 | None | 0.90A | 2qhfA-4ka8A:undetectable | 2qhfA-4ka8A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgl | GLYCINEDEHYDROGENASE[DECARBOXYLATING] (Synechocystissp. PCC 6803) |
PF02347(GDC-P) | 3 | ARG A 433GLN A 200PRO A 199 | None | 1.01A | 2qhfA-4lglA:undetectable | 2qhfA-4lglA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgv | GLUCOSE-6-PHOSPHATE1-DEHYDROGENASE (Mycobacteriumavium) |
PF00479(G6PD_N)PF02781(G6PD_C) | 3 | ARG A 317GLN A 458PRO A 459 | None | 0.89A | 2qhfA-4lgvA:undetectable | 2qhfA-4lgvA:24.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oem | DIPEPTIDYL PEPTIDASE1 HEAVY CHAIN (Homo sapiens) |
PF00112(Peptidase_C1)PF08773(CathepsinC_exc) | 3 | ARG A 226GLN A 262PRO A 261 | None | 0.91A | 2qhfA-4oemA:undetectable | 2qhfA-4oemA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2c | CRISPR-ASSOCIATEDHELICASE CAS3 (Thermobaculumterrenum) |
PF00271(Helicase_C) | 3 | ARG A 890GLN A 604PRO A 601 | None | 0.70A | 2qhfA-4q2cA:undetectable | 2qhfA-4q2cA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r3f | SPLICEOSOMAL PROTEINCWC27 (Chaetomiumthermophilum) |
PF00160(Pro_isomerase) | 3 | ARG A 158GLN A 10PRO A 11 | None | 0.90A | 2qhfA-4r3fA:undetectable | 2qhfA-4r3fA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ras | OXIDOREDUCTASE,NAD-BINDING/IRON-SULFUR CLUSTER-BINDINGPROTEIN (Nitratireductorpacificus) |
PF12838(Fer4_7)PF13486(Dehalogenase) | 3 | ARG A 287GLN A 658PRO A 659 | None | 0.85A | 2qhfA-4rasA:undetectable | 2qhfA-4rasA:24.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x3m | RNA 2'-O RIBOSEMETHYLTRANSFERASE (Thermusthermophilus) |
PF00588(SpoU_methylase) | 3 | ARG A 23GLN A 150PRO A 149 | None | 1.00A | 2qhfA-4x3mA:undetectable | 2qhfA-4x3mA:26.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xix | CARBONIC ANHYDRASE,ALPHA TYPE (Chlamydomonasreinhardtii) |
PF00194(Carb_anhydrase) | 3 | ARG A 173GLN A 299PRO A 98 | None | 0.99A | 2qhfA-4xixA:undetectable | 2qhfA-4xixA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydq | PROLINE--TRNA LIGASE (Plasmodiumfalciparum) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 3 | ARG A 403GLN A 395PRO A 396 | None | 1.00A | 2qhfA-4ydqA:undetectable | 2qhfA-4ydqA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zzh | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 3 | ARG A 276GLN A 294PRO A 293 | None | 0.93A | 2qhfA-4zzhA:undetectable | 2qhfA-4zzhA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5awp | ISOMALTODEXTRANASE (Arthrobacterglobiformis) |
no annotation | 3 | ARG A 304GLN A 517PRO A 397 | None | 0.66A | 2qhfA-5awpA:undetectable | 2qhfA-5awpA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bq2 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00275(EPSP_synthase) | 3 | ARG A 155GLN A 137PRO A 150 | None | 0.73A | 2qhfA-5bq2A:undetectable | 2qhfA-5bq2A:25.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d8g | TRYPTOPHANASE (Escherichiacoli) |
PF01212(Beta_elim_lyase) | 3 | ARG A 241GLN A 203PRO A 204 | None | 0.97A | 2qhfA-5d8gA:undetectable | 2qhfA-5d8gA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5df0 | AC-CHIA (Autographacalifornicamultiplenucleopolyhedrovirus) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 3 | ARG A 206GLN A 226PRO A 221 | None | 0.89A | 2qhfA-5df0A:undetectable | 2qhfA-5df0A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmq | REVERSETRANSCRIPTASE/RIBONUCLEASE H P80 (Murine leukemiavirus) |
PF00075(RNase_H)PF00078(RVT_1) | 3 | ARG A 585GLN A 639PRO A 636 | None | 0.95A | 2qhfA-5dmqA:undetectable | 2qhfA-5dmqA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g06 | EXOSOME COMPLEXCOMPONENT RRP46EXOSOME COMPLEXCOMPONENT CSL4 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF01138(RNase_PH)PF03725(RNase_PH_C)PF10447(EXOSC1) | 3 | ARG I 142GLN D 45PRO D 43 | None | 1.00A | 2qhfA-5g06I:undetectable | 2qhfA-5g06I:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gl9 | BETA-LACTAMASE (Burkholderiathailandensis) |
PF13354(Beta-lactamase2) | 3 | ARG A 165GLN A 146PRO A 145 | None | 0.85A | 2qhfA-5gl9A:undetectable | 2qhfA-5gl9A:26.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8y | SULFITE REDUCTASE[FERREDOXIN],CHLOROPLASTIC (Zea mays) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 3 | ARG A 321GLN A 504PRO A 541 | None | 0.88A | 2qhfA-5h8yA:undetectable | 2qhfA-5h8yA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ibk | POLYUBIQUITIN-B (Homo sapiens) |
no annotation | 3 | ARG F 74GLN F 31PRO F 37 | None | 0.89A | 2qhfA-5ibkF:undetectable | 2qhfA-5ibkF:13.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k0y | EUKARYOTICINITIATION FACTOR 2GAMMA SUBUNIT(EIF2-GAMMA) (Oryctolaguscuniculus) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF09173(eIF2_C) | 3 | ARG S 398GLN S 219PRO S 179 | None | 0.85A | 2qhfA-5k0yS:undetectable | 2qhfA-5k0yS:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l0l | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 3 | ARG A 227GLN A 262PRO A 243 | None | 0.96A | 2qhfA-5l0lA:undetectable | 2qhfA-5l0lA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lq4 | CYAGOX (Cyanothece sp.PCC 7425) |
PF00881(Nitroreductase) | 3 | ARG A 323GLN A 354PRO A 355 | None | 0.99A | 2qhfA-5lq4A:undetectable | 2qhfA-5lq4A:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m1t | MUCRPHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF00563(EAL) | 3 | ARG A 473GLN A 455PRO A 674 | C2E A 701 (-2.4A)C2E A 701 (-3.0A)C2E A 701 (-4.7A) | 1.01A | 2qhfA-5m1tA:undetectable | 2qhfA-5m1tA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ool | 39S RIBOSOMALPROTEIN L38,MITOCHONDRIAL (Homo sapiens) |
PF01161(PBP) | 3 | ARG 6 364GLN 6 361PRO 6 362 | A A2858 ( 3.5A)NoneNone | 0.99A | 2qhfA-5ool6:undetectable | 2qhfA-5ool6:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t03 | MALTOSE BINDINGPROTEIN - HEPARANSULFATE6-O-SULFOTRANSFERASEISOFORM 3 FUSIONPROTEIN (Escherichiacoli;Danio rerio) |
PF03567(Sulfotransfer_2)PF13416(SBP_bac_8) | 3 | ARG A 66GLN A1345PRO A 48 | GLC A1410 (-3.8A)NoneNone | 0.96A | 2qhfA-5t03A:undetectable | 2qhfA-5t03A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tf0 | GLYCOSYL HYDROLASEFAMILY 3 N-TERMINALDOMAIN PROTEIN (Bacteroidesintestinalis) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 3 | ARG A 529GLN A 538PRO A 535 | None | 0.89A | 2qhfA-5tf0A:undetectable | 2qhfA-5tf0A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wea | PROTEIN ARGONAUTE-2 (Homo sapiens) |
no annotation | 3 | ARG A 460GLN A 496PRO A 458 | None | 0.95A | 2qhfA-5weaA:undetectable | 2qhfA-5weaA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjs | GEM-ASSOCIATEDPROTEIN 2 (Homo sapiens) |
no annotation | 3 | ARG 2 245GLN 2 103PRO 2 98 | None | 0.98A | 2qhfA-5xjs2:undetectable | 2qhfA-5xjs2:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxo | PERIPLASMICBETA-GLUCOSIDASE (Bacteroidesthetaiotaomicron) |
no annotation | 3 | ARG A 527GLN A 536PRO A 533 | None | 0.84A | 2qhfA-5xxoA:undetectable | 2qhfA-5xxoA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y7o | UGGT (Thermomycesdupontii) |
PF06427(UDP-g_GGTase) | 3 | ARG A 811GLN A 663PRO A 662 | None | 0.97A | 2qhfA-5y7oA:undetectable | 2qhfA-5y7oA:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fc0 | EUKARYOTICTRANSLATIONINITIATION FACTOR 4G (Chaetomiumthermophilum) |
no annotation | 3 | ARG B 963GLN B 954PRO B 955 | None | 0.72A | 2qhfA-6fc0B:undetectable | 2qhfA-6fc0B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gi2 | FERRIC ENTEROBACTINESTERASE (Pseudomonasaeruginosa) |
no annotation | 3 | ARG A 150GLN A 45PRO A 48 | None | 0.98A | 2qhfA-6gi2A:undetectable | 2qhfA-6gi2A:undetectable |