SIMILAR PATTERNS OF AMINO ACIDS FOR 2QHF_A_ACTA508_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		4 LEU A  36
ASP A  34
ALA A  35
ILE A   6
 None
 1.11A 2qhfA-1agxA:
0.0		 2qhfA-1agxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		4 LEU A 133
ASP A 138
ALA A 160
ILE A 116
 None
 1.08A 2qhfA-1dbiA:
0.0		 2qhfA-1dbiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dof ADENYLOSUCCINATE
LYASE

(Pyrobaculum
aerophilum) 		PF00206
(Lyase_1) 		4 LEU A 112
ARG A 109
ALA A 111
ILE A 177
 None
 1.17A 2qhfA-1dofA:
undetectable		 2qhfA-1dofA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		4 LEU A 249
ARG A 246
ALA A 248
ILE A 271
 None
 1.14A 2qhfA-1eb3A:
0.0		 2qhfA-1eb3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE

(Saccharomyces
cerevisiae) 		PF03051
(Peptidase_C1_2) 		4 LEU A 195
ARG A 192
ALA A 194
ILE A 118
 None
SO4  A 802 (-3.8A)
None
None
 0.97A 2qhfA-1gcbA:
0.0		 2qhfA-1gcbA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmx THIOSULFATE
SULFURTRANSFERASE
GLPE

(Escherichia
coli) 		PF00581
(Rhodanese) 		4 LEU A  23
ASP A  25
ALA A  40
ILE A  89
 None
 1.14A 2qhfA-1gmxA:
undetectable		 2qhfA-1gmxA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 LEU A 540
ASP A 730
ALA A 538
ILE A 638
 None
 1.13A 2qhfA-1h7wA:
0.0		 2qhfA-1h7wA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 LEU A 339
ARG A 340
ALA A 329
ILE A 317
 None
None
MLZ  A 326 ( 3.6A)
None
 0.96A 2qhfA-1iv8A:
0.0		 2qhfA-1iv8A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp0 CREATINE
AMIDINOHYDROLASE

(Actinobacillus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 LEU A 139
ARG A 132
ALA A 138
ILE A 122
 None
 1.16A 2qhfA-1kp0A:
0.0		 2qhfA-1kp0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nh3 DNA TOPOISOMERASE I

(Homo sapiens) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N)
PF14370
(Topo_C_assoc) 		4 LEU A 479
ASP A 464
ALA A 476
ILE A 457
 None
 0.93A 2qhfA-1nh3A:
undetectable		 2qhfA-1nh3A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		4 LEU A 226
ARG A 211
ASP A 229
ALA A 231
 None
 1.01A 2qhfA-1oaaA:
undetectable		 2qhfA-1oaaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oct PROTEIN (OCT-1 POU
DOMAIN)

(Homo sapiens) 		PF00046
(Homeobox)
PF00157
(Pou) 		4 LEU C 116
ARG C 113
ALA C 115
ILE C 108
 None
 0.93A 2qhfA-1octC:
undetectable		 2qhfA-1octC:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg3 ALLANTOICASE

(Saccharomyces
cerevisiae) 		PF03561
(Allantoicase) 		4 LEU A 222
ARG A 339
ALA A 205
ILE A 338
 None
 1.06A 2qhfA-1sg3A:
undetectable		 2qhfA-1sg3A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vla HYDROPEROXIDE
RESISTANCE PROTEIN
OSMC

(Thermotoga
maritima) 		PF02566
(OsmC) 		4 LEU A  22
ASP A  24
ALA A  35
ILE A   6
 None
 0.96A 2qhfA-1vlaA:
undetectable		 2qhfA-1vlaA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yal CHYMOPAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1) 		4 LEU A 125
ARG A 195
ALA A 124
ILE A 175
 None
 1.05A 2qhfA-1yalA:
undetectable		 2qhfA-1yalA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		4 LEU A 389
ARG A 391
ASP A 385
ALA A 384
 None
 1.13A 2qhfA-2b3bA:
undetectable		 2qhfA-2b3bA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4z TGTWINSCAN_2721 - E2
DOMAIN

(Toxoplasma
gondii) 		PF00179
(UQ_con) 		4 LEU A 148
ARG A 145
ALA A 147
ILE A  44
 None
 0.97A 2qhfA-2f4zA:
undetectable		 2qhfA-2f4zA:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		5 LEU A 108
ARG A 110
ASP A 117
ALA A 129
ILE A 338
 None
 1.14A 2qhfA-2g85A:
59.1		 2qhfA-2g85A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 637
ASP A 630
ALA A 633
ILE A 652
 None
 1.05A 2qhfA-2hnhA:
undetectable		 2qhfA-2hnhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ism PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF07995
(GSDH) 		4 LEU A  80
ARG A 139
ALA A  37
ILE A 140
 None
 1.07A 2qhfA-2ismA:
undetectable		 2qhfA-2ismA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l5a HISTONE H3-LIKE
CENTROMERIC PROTEIN
CSE4, PROTEIN SCM3,
HISTONE H4

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF10384
(Scm3)
PF15511
(CENP-T_C) 		4 LEU A 213
ASP A 208
ALA A 212
ILE A 102
 None
 1.09A 2qhfA-2l5aA:
undetectable		 2qhfA-2l5aA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01933
(UPF0052) 		4 LEU A 132
ASP A  37
ALA A  36
ILE A 148
 None
 1.15A 2qhfA-2o2zA:
undetectable		 2qhfA-2o2zA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 LEU A 333
ARG A 344
ALA A 369
ILE A 311
 None
 0.93A 2qhfA-2ohhA:
undetectable		 2qhfA-2ohhA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		4 LEU A  96
ASP A  93
ALA A  95
ILE A 158
 None
 1.09A 2qhfA-2ojhA:
undetectable		 2qhfA-2ojhA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwq UBIQUITIN
CONJUGATING ENZYME

(Plasmodium
yoelii) 		PF00179
(UQ_con) 		4 LEU A 105
ARG A 102
ALA A 104
ILE A  14
 None
 0.93A 2qhfA-2pwqA:
undetectable		 2qhfA-2pwqA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		4 LEU A 276
ARG A 277
ALA A 272
ILE A 265
 None
 1.04A 2qhfA-2qm1A:
undetectable		 2qhfA-2qm1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU X  21
ARG X  38
ALA X  20
ILE X  69
 None
 1.05A 2qhfA-2qvxX:
undetectable		 2qhfA-2qvxX:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 LEU A 307
ASP A 165
ALA A 311
ILE A 305
 None
FAD  A 403 (-4.8A)
None
None
 0.93A 2qhfA-2rgjA:
undetectable		 2qhfA-2rgjA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 LEU G 402
ARG G 412
ALA G 398
ILE G 407
 None
 1.17A 2qhfA-2uv8G:
undetectable		 2qhfA-2uv8G:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 378
ARG A 433
ALA A 404
ILE A 435
 None
 1.03A 2qhfA-2wvgA:
undetectable		 2qhfA-2wvgA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycd GLUTATHIONE
S-TRANSFERASE

(Agrobacterium
tumefaciens) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 LEU A  42
ARG A  39
ALA A  41
ILE A  19
 None
 1.10A 2qhfA-2ycdA:
undetectable		 2qhfA-2ycdA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Plasmodium
vivax) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 LEU A 116
ARG A  84
ALA A 115
ILE A  87
 None
 0.95A 2qhfA-2yneA:
undetectable		 2qhfA-2yneA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 LEU A 291
ARG A 292
ALA A 325
ILE A 341
 None
 1.15A 2qhfA-3a8kA:
undetectable		 2qhfA-3a8kA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 LEU A 326
ARG A 378
ASP A 329
ALA A 330
 None
 1.08A 2qhfA-3bdlA:
undetectable		 2qhfA-3bdlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyk 27KDA OUTER MEMBRANE
PROTEIN

(Ruegeria
pomeroyi) 		PF13462
(Thioredoxin_4) 		4 LEU A  73
ARG A  70
ALA A  72
ILE A 127
 None
 1.09A 2qhfA-3gykA:
undetectable		 2qhfA-3gykA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhf TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		no annotation 4 ARG B 138
ASP B  98
ALA B 143
ILE B 136
 None
 1.07A 2qhfA-3hhfB:
undetectable		 2qhfA-3hhfB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A 104
ARG A 100
ASP A 102
ILE A  99
 None
 1.11A 2qhfA-3hi8A:
undetectable		 2qhfA-3hi8A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibh SACCHAROMYCES
CEREVISIAE GTT2

(Saccharomyces
cerevisiae) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 LEU A  37
ARG A  34
ALA A  36
ILE A  21
 None
 1.18A 2qhfA-3ibhA:
undetectable		 2qhfA-3ibhA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		4 LEU A 402
ARG A 399
ALA A 401
ILE A 209
 None
 0.91A 2qhfA-3j1eA:
undetectable		 2qhfA-3j1eA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 LEU B 571
ARG B 568
ALA B 570
ILE B 738
 None
 0.85A 2qhfA-3k70B:
undetectable		 2qhfA-3k70B:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb5 TRIPARTITE
MOTIF-CONTAINING
PROTEIN 72

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 LEU A 382
ASP A 454
ALA A 358
ILE A 362
 None
 1.18A 2qhfA-3kb5A:
undetectable		 2qhfA-3kb5A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		4 LEU A  61
ASP A  71
ALA A  60
ILE A 360
 None
 1.16A 2qhfA-3koyA:
undetectable		 2qhfA-3koyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9x GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFC,
LINKER, ANCILLARY
PROTEIN KEFF

(Escherichia
coli) 		PF02254
(TrkA_N)
PF02525
(Flavodoxin_2) 		4 LEU A1053
ARG A1033
ALA A1056
ILE A1005
 None
 1.09A 2qhfA-3l9xA:
undetectable		 2qhfA-3l9xA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 440
ARG A 437
ALA A 439
ILE A   4
 None
 0.88A 2qhfA-3ll3A:
undetectable		 2qhfA-3ll3A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7z ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 LEU A  20
ARG A  17
ALA A  19
ILE A  40
 None
 1.14A 2qhfA-3n7zA:
undetectable		 2qhfA-3n7zA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogg BOTULINUM NEUROTOXIN
TYPE D

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 LEU A 918
ASP A 881
ALA A 887
ILE A1062
 None
 1.06A 2qhfA-3oggA:
undetectable		 2qhfA-3oggA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 LEU A 315
ARG A 312
ALA A 314
ILE A 277
 None
 1.07A 2qhfA-3pdiA:
undetectable		 2qhfA-3pdiA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE

(Sphaerobacter
thermophilus) 		PF07228
(SpoIIE) 		4 LEU A 174
ASP A 205
ALA A 204
ILE A 164
 None
 1.13A 2qhfA-3pu9A:
undetectable		 2qhfA-3pu9A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3e UNCHARACTERIZED
PROTEIN YQJG

(Escherichia
coli) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 LEU A 182
ASP A 239
ALA A 238
ILE A 223
 None
 0.81A 2qhfA-3r3eA:
undetectable		 2qhfA-3r3eA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor) 		PF01244
(Peptidase_M19) 		4 LEU A  27
ASP A 322
ALA A  26
ILE A  40
 None
EDO  A 407 (-3.7A)
EDO  A 407 ( 4.1A)
None
 0.92A 2qhfA-3s2jA:
undetectable		 2qhfA-3s2jA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2

(Rattus
norvegicus) 		PF01070
(FMN_dh) 		4 LEU A 147
ARG A 124
ALA A 144
ILE A 115
 None
 1.12A 2qhfA-3sgzA:
undetectable		 2qhfA-3sgzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		4 LEU A 355
ASP A 382
ALA A 358
ILE A 353
 None
 1.05A 2qhfA-3x0uA:
undetectable		 2qhfA-3x0uA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		4 LEU A 207
ARG A 204
ALA A 152
ILE A 192
 None
 0.99A 2qhfA-3zdnA:
undetectable		 2qhfA-3zdnA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuz PROTEIN SHQ1

(Saccharomyces
cerevisiae) 		PF04925
(SHQ1) 		4 LEU A 377
ARG A 374
ALA A 376
ILE A 466
 None
 0.97A 2qhfA-3zuzA:
undetectable		 2qhfA-3zuzA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		4 LEU A 387
ARG A 384
ALA A 386
ILE A 440
 None
 1.10A 2qhfA-4ddqA:
2.1		 2qhfA-4ddqA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6c AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		PF07993
(NAD_binding_4) 		4 LEU A2287
ARG A2166
ALA A2286
ILE A2168
 None
 1.12A 2qhfA-4f6cA:
undetectable		 2qhfA-4f6cA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		no annotation 4 LEU B2287
ARG B2166
ALA B2286
ILE B2168
 None
 1.16A 2qhfA-4f6lB:
undetectable		 2qhfA-4f6lB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxz SUPPRESSION OF
COPPER SENSITIVITY
PROTEIN

(Salmonella
enterica) 		PF01323
(DSBA) 		4 LEU A  90
ARG A  87
ALA A  89
ILE A 141
 None
 1.01A 2qhfA-4gxzA:
undetectable		 2qhfA-4gxzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE

(Solanum
tuberosum) 		PF00332
(Glyco_hydro_17) 		4 LEU A  68
ASP A  40
ALA A  67
ILE A  57
 None
 1.12A 2qhfA-4gziA:
undetectable		 2qhfA-4gziA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hse CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF00004
(AAA) 		4 LEU A 420
ARG A 417
ALA A 419
ILE A 435
 None
 1.11A 2qhfA-4hseA:
undetectable		 2qhfA-4hseA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		4 LEU A 140
ARG A 137
ALA A 139
ILE A 132
 None
 1.03A 2qhfA-4hxyA:
undetectable		 2qhfA-4hxyA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		4 LEU A 237
ARG A 239
ALA A 105
ILE A 255
 None
 0.99A 2qhfA-4impA:
undetectable		 2qhfA-4impA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05544
(Pro_racemase) 		4 LEU A 193
ARG A 190
ALA A 192
ILE A 209
 None
 0.97A 2qhfA-4j9wA:
undetectable		 2qhfA-4j9wA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4juu EPIMERASE

(Xanthomonas
campestris) 		PF05544
(Pro_racemase) 		4 LEU A 193
ARG A 190
ALA A 192
ILE A 209
 None
 0.98A 2qhfA-4juuA:
undetectable		 2qhfA-4juuA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6x DISULFIDE
OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF13462
(Thioredoxin_4) 		4 ARG A 150
ASP A 115
ALA A 113
ILE A 146
 None
 1.12A 2qhfA-4k6xA:
undetectable		 2qhfA-4k6xA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj7 RRNA-PROCESSING
PROTEIN UTP23

(Saccharomyces
cerevisiae) 		PF04900
(Fcf1) 		4 LEU A  69
ARG A  86
ALA A  68
ILE A  61
 None
 1.14A 2qhfA-4mj7A:
undetectable		 2qhfA-4mj7A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0v GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN

(Marinobacter
hydrocarbonoclasticus) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		4 LEU A  19
ARG A  16
ALA A  18
ILE A   3
 None
 1.18A 2qhfA-4n0vA:
undetectable		 2qhfA-4n0vA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Pseudomonas
aeruginosa) 		PF02525
(Flavodoxin_2) 		4 LEU A 171
ARG A 168
ALA A 170
ILE A 142
 None
 1.08A 2qhfA-4n9qA:
undetectable		 2qhfA-4n9qA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7h GLUTATHIONE
S-TRANSFERASE

(Rhodospirillum
rubrum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 LEU A  94
ASP A 163
ALA A 162
ILE A 144
 None
 1.15A 2qhfA-4o7hA:
undetectable		 2qhfA-4o7hA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 ARG A 447
ASP A 441
ALA A 456
ILE A 449
 None
 1.15A 2qhfA-4ozyA:
undetectable		 2qhfA-4ozyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae;
Vibrio cholerae) 		PF02508
(Rnf-Nqr)
PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU E  69
ASP E  67
ALA E  68
ILE F   4
 None
 0.83A 2qhfA-4p6vE:
undetectable		 2qhfA-4p6vE:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis) 		PF12741
(SusD-like) 		4 LEU A 415
ARG A 322
ALA A 413
ILE A 325
 None
 1.07A 2qhfA-4pucA:
undetectable		 2qhfA-4pucA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2n INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A 438
ASP A 422
ALA A 441
ILE A 426
 None
 1.12A 2qhfA-4q2nA:
undetectable		 2qhfA-4q2nA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		4 LEU A 172
ASP A 306
ALA A 171
ILE A 184
 None
 1.12A 2qhfA-4r9iA:
undetectable		 2qhfA-4r9iA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		4 LEU A 278
ARG A 281
ALA A 272
ILE A 436
 None
 1.12A 2qhfA-4u98A:
undetectable		 2qhfA-4u98A:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhh ESTERASE

(Thermogutta
terrifontis) 		PF00561
(Abhydrolase_1) 		4 LEU A  82
ARG A 117
ALA A  79
ILE A  95
 None
 1.03A 2qhfA-4uhhA:
undetectable		 2qhfA-4uhhA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 LEU A  54
ARG A  76
ASP A  48
ALA A  47
 None
 1.00A 2qhfA-4v15A:
undetectable		 2qhfA-4v15A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		4 LEU A 256
ARG A 253
ALA A 255
ILE A   5
 None
 1.01A 2qhfA-4zrqA:
undetectable		 2qhfA-4zrqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		4 LEU A 587
ASP A 615
ALA A 586
ILE A 580
 None
 1.08A 2qhfA-5cj5A:
undetectable		 2qhfA-5cj5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czy LEGIONELLA EFFECTOR
LEGAS4

(Legionella
pneumophila) 		PF00023
(Ank)
PF00856
(SET) 		4 LEU A 353
ASP A 314
ALA A 358
ILE A 292
 None
 1.18A 2qhfA-5czyA:
undetectable		 2qhfA-5czyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 LEU A1111
ARG A1190
ALA A1130
ILE A1195
 None
 0.95A 2qhfA-5d0fA:
undetectable		 2qhfA-5d0fA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 LEU B 500
ARG B 503
ALA B 610
ILE B 539
 None
 1.18A 2qhfA-5dlqB:
undetectable		 2qhfA-5dlqB:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 499
ARG A 496
ALA A 493
ILE A 469
 None
 0.95A 2qhfA-5e6kA:
undetectable		 2qhfA-5e6kA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 499
ARG A 496
ALA A 493
ILE A 469
 None
 0.86A 2qhfA-5enyA:
undetectable		 2qhfA-5enyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 637
ASP A 630
ALA A 633
ILE A 652
 None
 1.17A 2qhfA-5fkuA:
undetectable		 2qhfA-5fkuA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 LEU A 392
ARG A 526
ASP A 529
ALA A 389
 None
 1.18A 2qhfA-5jozA:
undetectable		 2qhfA-5jozA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kol UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF02464
(CinA) 		4 LEU A 164
ARG A 161
ALA A 163
ILE A  17
 None
None
None
CL  A 201 (-4.6A)
 1.18A 2qhfA-5kolA:
undetectable		 2qhfA-5kolA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 LEU A 489
ASP A 410
ALA A 488
ILE A 446
 None
 1.07A 2qhfA-5lq3A:
undetectable		 2qhfA-5lq3A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm2 CAPSID PROTEIN VP4A

(Nora virus) 		no annotation 4 LEU C  24
ASP C  31
ALA C  25
ILE C 168
 None
 1.08A 2qhfA-5mm2C:
undetectable		 2qhfA-5mm2C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr1 FTSZ-BINDING PROTEIN
FZLA

(Caulobacter
vibrioides) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 LEU A 100
ASP A 169
ALA A 168
ILE A 150
 None
 0.96A 2qhfA-5nr1A:
undetectable		 2qhfA-5nr1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol1 DNA POLYMERASE III
SUBUNIT ALPHA,DNA
POLYMERASE III
SUBUNIT ALPHA

(Synechocystis
sp. PCC 6803) 		no annotation 4 LEU A  44
ASP A  17
ALA A  43
ILE A  50
 None
CSO  A  37 ( 3.0A)
None
None
 0.78A 2qhfA-5ol1A:
undetectable		 2qhfA-5ol1A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuf TETRACYCLINE
DESTRUCTASE TET(50)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 LEU A 286
ASP A 156
ALA A 290
ILE A 284
 None
 1.04A 2qhfA-5tufA:
undetectable		 2qhfA-5tufA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 LEU A 286
ASP A 156
ALA A 290
ILE A 284
 None
 1.01A 2qhfA-5tulA:
undetectable		 2qhfA-5tulA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6b PDZ
DOMAIN-CONTAINING
PROTEIN GIPC1

(Mus musculus) 		PF00595
(PDZ) 		4 LEU A 283
ASP A 269
ALA A 284
ILE A 278
 None
 1.16A 2qhfA-5v6bA:
undetectable		 2qhfA-5v6bA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6e PDZ
DOMAIN-CONTAINING
PROTEIN GIPC1

(Mus musculus) 		no annotation 4 LEU A 283
ASP A 269
ALA A 284
ILE A 278
 None
 1.17A 2qhfA-5v6eA:
undetectable		 2qhfA-5v6eA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8w INTEGRATOR COMPLEX
SUBUNIT 9

(Homo sapiens) 		no annotation 4 LEU A 643
ARG A 644
ALA A 622
ILE A 635
 None
 1.14A 2qhfA-5v8wA:
undetectable		 2qhfA-5v8wA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 4 LEU A 272
ASP A 150
ALA A 276
ILE A 270
 None
 0.98A 2qhfA-5xgvA:
undetectable		 2qhfA-5xgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 ARG C  70
ASP C  23
ALA C  27
ILE C  85
 None
 1.07A 2qhfA-5y3rC:
undetectable		 2qhfA-5y3rC:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y82 MEMBRANE PROTEIN
INSERTASE YIDC

(Thermotoga
maritima) 		no annotation 4 LEU D 217
ARG D 199
ALA D 216
ILE D 202
 None
 1.01A 2qhfA-5y82D:
undetectable		 2qhfA-5y82D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywz SUN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 LEU A 811
ARG A 810
ALA A 746
ILE A 885
 None
 0.98A 2qhfA-5ywzA:
undetectable		 2qhfA-5ywzA:
undetectable