SIMILAR PATTERNS OF AMINO ACIDS FOR 2QHC_B_AB1B9001_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30VAL A 32GLY A 49PRO A 81VAL A 82ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 ( 4.7A)A79 A 800 ( 4.3A)A79 A 800 (-3.4A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.37A | 2qhcB-1hvcA:14.1 | 2qhcB-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30VAL A 32GLY A 49VAL A 82ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 4.9A)A79 A 800 ( 4.4A)A79 A 800 ( 3.7A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.48A | 2qhcB-1hvcA:14.1 | 2qhcB-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30VAL A 32PRO A 81VAL A 82ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 4.9A)A79 A 800 ( 4.4A)A79 A 800 ( 3.9A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.50A | 2qhcB-1hvcA:14.1 | 2qhcB-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ASP A 25GLY A 27ALA A 28ASP A 30VAL A 32GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 (-3.2A)A79 A 800 ( 4.7A)A79 A 800 ( 4.3A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.45A | 2qhcB-1hvcA:14.1 | 2qhcB-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 30VAL A 32GLY A 49ILE A 50VAL A 82ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-3.1A)A79 A 800 ( 4.9A)A79 A 800 ( 4.4A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.53A | 2qhcB-1hvcA:14.1 | 2qhcB-1hvcA:98.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 30VAL A 32ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-3.1A)A79 A 800 ( 4.9A)A79 A 800 ( 4.4A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.51A | 2qhcB-1hvcA:14.1 | 2qhcB-1hvcA:98.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kz1 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (Schizosaccharomycespombe) |
PF00885(DMRL_synthase) | 5 | GLY A 147ALA A 150GLY A 83ILE A 84ILE A 20 | None | 0.95A | 2qhcB-1kz1A:undetectable | 2qhcB-1kz1A:28.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1naa | CELLOBIOSEDEHYDROGENASE (Phanerochaetechrysosporium) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 223ALA A 224VAL A 407GLY A 305ILE A 229 | 6FA A 801 (-3.0A)6FA A 801 ( 4.9A)None6FA A 801 (-3.5A)None | 1.02A | 2qhcB-1naaA:undetectable | 2qhcB-1naaA:11.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 30VAL A 32PRO A 81ILE A 84 | None | 0.71A | 2qhcB-1q9pA:10.1 | 2qhcB-1q9pA:93.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30VAL A 32ILE A 84 | None | 0.51A | 2qhcB-1q9pA:10.1 | 2qhcB-1q9pA:93.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rcq | CATABOLIC ALANINERACEMASE DADX (Pseudomonasaeruginosa) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | GLY A 315ALA A 314ILE A 265VAL A 286ILE A 288 | None | 0.98A | 2qhcB-1rcqA:undetectable | 2qhcB-1rcqA:16.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 9 | ARG A 8ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49PRO A 81ILE A 84 | None | 0.53A | 2qhcB-1sivA:18.2 | 2qhcB-1sivA:50.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 8 | ARG A 8ASP A 25GLY A 27ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.65A | 2qhcB-1sivA:18.2 | 2qhcB-1sivA:50.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tjr | BX1 (Zea mays) |
PF00290(Trp_syntA) | 5 | GLY A 307ALA A 308ASP A 309VAL A 269ILE A 303 | None | 0.95A | 2qhcB-1tjrA:undetectable | 2qhcB-1tjrA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usy | ATPPHOSPHORIBOSYLTRANSFERASE REGULATORYSUBUNIT (Thermotogamaritima) |
PF13393(tRNA-synt_His) | 5 | ALA C 251VAL C 114ILE C 238VAL C 109ILE C 113 | None | 0.53A | 2qhcB-1usyC:undetectable | 2qhcB-1usyC:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uww | ENDOGLUCANASE (Bacillus akibai) |
PF03424(CBM_17_28) | 5 | ALA A 122VAL A 89ILE A 169VAL A 147ILE A 149 | None | 0.88A | 2qhcB-1uwwA:undetectable | 2qhcB-1uwwA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5f | PYRUVATE OXIDASE (Aerococcusviridans) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ASP A 388ALA A 444ASP A 442VAL A 466ILE A 440 | NoneTPP A1602 (-3.7A) MG A1603 ( 2.8A)NoneNone | 0.88A | 2qhcB-1v5fA:undetectable | 2qhcB-1v5fA:10.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5j | KIAA1355 PROTEIN (Homo sapiens) |
PF00041(fn3) | 5 | GLY A 85ALA A 84VAL A 33GLY A 60PRO A 11 | None | 0.93A | 2qhcB-1v5jA:undetectable | 2qhcB-1v5jA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w3f | HEMOLYTIC LECTINFROM LAETIPORUSSULPHUREUS (Laetiporussulphureus) |
PF03318(ETX_MTX2) | 5 | GLY A 241GLY A 296ILE A 297PRO A 221VAL A 220 | None | 1.04A | 2qhcB-1w3fA:undetectable | 2qhcB-1w3fA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdw | TRYPTOPHAN SYNTHASEBETA CHAIN 1 (Pyrococcusfuriosus) |
PF00291(PALP) | 5 | GLY B 65ALA B 66VAL B 221VAL B 368ILE B 366 | None | 1.07A | 2qhcB-1wdwB:undetectable | 2qhcB-1wdwB:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yg0 | COP ASSOCIATEDPROTEIN (Helicobacterpylori) |
PF00403(HMA) | 5 | GLY A 62ALA A 61ASP A 60VAL A 23ILE A 19 | None | 1.04A | 2qhcB-1yg0A:undetectable | 2qhcB-1yg0A:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zno | HYPOTHETICAL UPF0244PROTEIN VC0702 (Vibrio cholerae) |
PF01931(NTPase_I-T) | 5 | ARG A 74GLY A 77ALA A 78VAL A 44ILE A 14 | None | 0.82A | 2qhcB-1znoA:undetectable | 2qhcB-1znoA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bc0 | NADH OXIDASE (Streptococcuspyogenes) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 453ALA A 454ASP A 456ILE A 387ILE A 426 | None | 0.67A | 2qhcB-2bc0A:undetectable | 2qhcB-2bc0A:12.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 29VAL A 32GLY A 55PRO A 86VAL A 87ILE A 89 | LP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)NoneLP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 ( 4.9A)LP1 A 201 (-4.2A) | 0.52A | 2qhcB-2fmbA:15.1 | 2qhcB-2fmbA:30.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h00 | METHYLTRANSFERASE 10DOMAIN CONTAININGPROTEIN (Homo sapiens) |
PF05971(Methyltransf_10) | 5 | GLY A 84ALA A 85GLY A 69VAL A 120ILE A 118 | NoneNoneNoneDTU A2140 (-4.0A)None | 0.94A | 2qhcB-2h00A:undetectable | 2qhcB-2h00A:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | GLY A 190ALA A 189GLY A 183ILE A 180PRO A 296 | NoneNonePLP A 400 (-3.4A)PLP A 400 (-4.9A)PLP A 400 (-4.0A) | 0.84A | 2qhcB-2isqA:undetectable | 2qhcB-2isqA:15.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8ASP A 25GLY A 27ASP A 30GLY A 49ILE A 50PRO A 81 | AB1 A 501 ( 4.7A)AB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.8A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A) | 0.55A | 2qhcB-2rkfA:20.9 | 2qhcB-2rkfA:87.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | AB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.5A)AB1 A 501 ( 3.3A)AB1 A 501 (-3.8A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.35A | 2qhcB-2rkfA:20.9 | 2qhcB-2rkfA:87.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rsp | RSV PROTEASE (Rous sarcomavirus) |
PF00077(RVP) | 5 | ARG A 10ASP A 37ALA A 40ASP A 41ILE A 108 | None | 0.87A | 2qhcB-2rspA:12.8 | 2qhcB-2rspA:31.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rsp | RSV PROTEASE (Rous sarcomavirus) |
PF00077(RVP) | 5 | ASP A 37GLY A 39ALA A 40ASP A 41ILE A 108 | None | 0.25A | 2qhcB-2rspA:12.8 | 2qhcB-2rspA:31.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b1s | FLAGELLARBIOSYNTHETIC PROTEINFLHB (Aquifexaeolicus) |
PF01312(Bac_export_2) | 5 | ALA B 270VAL B 322GLY B 287ILE B 267VAL B 320 | None | 1.01A | 2qhcB-3b1sB:undetectable | 2qhcB-3b1sB:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c26 | PUTATIVEACETYLTRANSFERASETA0821 (Thermoplasmaacidophilum) |
PF00583(Acetyltransf_1) | 5 | ASP A 45VAL A 51GLY A 87VAL A 56ILE A 52 | NO3 A 266 (-3.1A)NoneEDO A 269 (-3.4A)NoneNone | 0.86A | 2qhcB-3c26A:undetectable | 2qhcB-3c26A:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgg | SAM-DEPENDENTMETHYLTRANSFERASE (Corynebacteriumglutamicum) |
PF13649(Methyltransf_25) | 5 | ASP A 51GLY A 53GLY A 145ILE A 144ILE A 59 | NoneNHE A 195 (-3.2A)NoneNHE A 195 ( 4.5A)None | 1.07A | 2qhcB-3cggA:undetectable | 2qhcB-3cggA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d43 | SPHERICASE (Lysinibacillussphaericus) |
PF00082(Peptidase_S8) | 5 | ALA A 97ASP A 96GLY A 92PRO A 254ILE A 30 | None | 1.06A | 2qhcB-3d43A:undetectable | 2qhcB-3d43A:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbg | PUTATIVE CYTOCHROMEP450 (Streptomycescoelicolor) |
PF00067(p450) | 5 | GLY A 359ALA A 360ASP A 361PRO A 24ILE A 356 | None | 0.92A | 2qhcB-3dbgA:undetectable | 2qhcB-3dbgA:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f6m | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Yersinia pestis) |
PF02542(YgbB) | 5 | GLY A 39ASP A 8GLY A 147PRO A 105ILE A 22 | None | 1.03A | 2qhcB-3f6mA:undetectable | 2qhcB-3f6mA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gve | YFKN PROTEIN (Bacillussubtilis) |
PF00149(Metallophos) | 5 | GLY A 121ALA A 122ASP A 123ILE A 89ILE A 126 | None | 0.70A | 2qhcB-3gveA:undetectable | 2qhcB-3gveA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdy | UDP-GALACTOPYRANOSEMUTASE (Deinococcusradiodurans) |
PF03275(GLF)PF13450(NAD_binding_8) | 5 | GLY A 38ALA A 37VAL A 237VAL A 55ILE A 57 | FAD A 450 (-3.3A)NoneNoneNoneNone | 0.95A | 2qhcB-3hdyA:undetectable | 2qhcB-3hdyA:12.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5g | MYOSIN HEAVY CHAINISOFORM A (Doryteuthispealeii) |
PF00063(Myosin_head)PF00612(IQ)PF02736(Myosin_N) | 5 | GLY A 264ALA A 265ASP A 266GLY A 460ILE A 459 | None | 0.75A | 2qhcB-3i5gA:undetectable | 2qhcB-3i5gA:8.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2z | BIRA BIFUNCTIONALPROTEIN (Mycobacteriumtuberculosis) |
PF02237(BPL_C)PF03099(BPL_LplA_LipB) | 5 | GLY A 50ALA A 51VAL A 56VAL A 152ILE A 53 | None | 1.03A | 2qhcB-3l2zA:undetectable | 2qhcB-3l2zA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lp6 | PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASECATALYTIC SUBUNIT (Mycobacteriumtuberculosis) |
PF00731(AIRC) | 5 | GLY A 71ALA A 70ASP A 19GLY A 122ILE A 121 | FMT A 175 (-4.1A)FMT A 175 ( 4.3A)FMT A 175 (-3.5A)NoneNone | 1.00A | 2qhcB-3lp6A:undetectable | 2qhcB-3lp6A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lun | ULILYSIN (Methanosarcinaacetivorans) |
PF05572(Peptidase_M43) | 5 | ALA A 209ASP A 207VAL A 175ILE A 93ILE A 205 | None | 0.84A | 2qhcB-3lunA:undetectable | 2qhcB-3lunA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwc | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Kosmotogaolearia) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 310ALA A 336ASP A 337VAL A 363ILE A 149 | None | 1.03A | 2qhcB-3mwcA:undetectable | 2qhcB-3mwcA:13.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwg | IRON-REGULATED ABCTRANSPORTERSIDEROPHORE-BINDINGPROTEIN SIRA (Staphylococcusaureus) |
PF01497(Peripla_BP_2) | 5 | ALA A 288ASP A 287ASP A 253ILE A 247VAL A 257 | None | 0.99A | 2qhcB-3mwgA:undetectable | 2qhcB-3mwgA:18.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 28ASP A 29ASP A 30VAL A 32GLY A 48 | None | 0.62A | 2qhcB-3mwsA:19.8 | 2qhcB-3mwsA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ARG A 8ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30VAL A 32PRO A 81VAL A 82ILE A 84 | None | 0.50A | 2qhcB-3mwsA:19.8 | 2qhcB-3mwsA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 11 | ARG A 8ASP A 25GLY A 27ALA A 28ASP A 29VAL A 32GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | None | 0.55A | 2qhcB-3mwsA:19.8 | 2qhcB-3mwsA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8ASP A 29GLY A 49ILE A 50PRO A 81 | None | 0.94A | 2qhcB-3mwsA:19.8 | 2qhcB-3mwsA:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8l | 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE (Oryctolaguscuniculus) |
PF00365(PFK) | 5 | GLY A 224ALA A 225ASP A 226ILE A 192VAL A 207 | PO4 A 767 ( 4.6A)NoneNoneNoneNone | 0.99A | 2qhcB-3o8lA:undetectable | 2qhcB-3o8lA:9.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8l | 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE (Oryctolaguscuniculus) |
PF00365(PFK) | 5 | GLY A 224ALA A 225ASP A 226VAL A 207ILE A 261 | PO4 A 767 ( 4.6A)NoneNoneNoneNone | 0.94A | 2qhcB-3o8lA:undetectable | 2qhcB-3o8lA:9.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oml | PEROXISOMALMULTIFUNCTIONALENZYME TYPE 2,CG3415 (Drosophilamelanogaster) |
PF00106(adh_short)PF01575(MaoC_dehydratas)PF13452(MaoC_dehydrat_N) | 5 | GLY A 69ASP A 63VAL A 62VAL A 39ILE A 65 | None | 1.02A | 2qhcB-3omlA:undetectable | 2qhcB-3omlA:9.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opy | 6-PHOSPHOFRUCTO-1-KINASE ALPHA-SUBUNIT (Komagataellapastoris) |
PF00365(PFK) | 5 | GLY A 419ALA A 420ASP A 421VAL A 402ILE A 457 | None | 0.82A | 2qhcB-3opyA:undetectable | 2qhcB-3opyA:7.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slz | GAG-PRO-POLPOLYPROTEIN (Murine leukemiavirus) |
PF00077(RVP) | 5 | ASP A 32GLY A 34ALA A 35VAL A 39GLY A 56 | 3TL A 126 (-2.4A)3TL A 126 (-3.1A)3TL A 126 ( 4.0A)None3TL A 126 (-3.4A) | 0.70A | 2qhcB-3slzA:11.0 | 2qhcB-3slzA:28.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slz | GAG-PRO-POLPOLYPROTEIN (Murine leukemiavirus) |
PF00077(RVP) | 5 | ASP A 32GLY A 34ALA A 35VAL A 39PRO A 89 | 3TL A 126 (-2.4A)3TL A 126 (-3.1A)3TL A 126 ( 4.0A)None3TL A 126 (-4.0A) | 0.58A | 2qhcB-3slzA:11.0 | 2qhcB-3slzA:28.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8ASP A 25GLY A 27ALA A 28ASP A 29VAL A 32GLY A 49ILE A 50 | SO4 A 101 (-3.8A)017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)017 A 201 (-3.5A)None017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.58A | 2qhcB-3t3cA:18.8 | 2qhcB-3t3cA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8ASP A 25GLY A 27ALA A 28ASP A 29VAL A 32GLY A 49PRO A 81 | SO4 A 101 (-3.8A)017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)017 A 201 (-3.5A)None017 A 201 (-4.0A)None | 0.74A | 2qhcB-3t3cA:18.8 | 2qhcB-3t3cA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30VAL A 32GLY A 49ILE A 50 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)017 A 201 (-3.5A)017 A 201 (-4.2A)None017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.43A | 2qhcB-3t3cA:18.8 | 2qhcB-3t3cA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30VAL A 32GLY A 49PRO A 81 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)017 A 201 (-3.5A)017 A 201 (-4.2A)None017 A 201 (-4.0A)None | 0.54A | 2qhcB-3t3cA:18.8 | 2qhcB-3t3cA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ARG A 8ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | 017 A 201 ( 4.8A)017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.4A)017 A 201 (-3.3A)017 A 201 (-4.6A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.52A | 2qhcB-3ttpA:19.6 | 2qhcB-3ttpA:79.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ARG A 8ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 50PRO A 81 | None017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.4A)017 A 201 (-3.2A)017 A 201 ( 4.0A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.49A | 2qhcB-3u7sA:19.8 | 2qhcB-3u7sA:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81 | 017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.4A)017 A 201 (-3.2A)017 A 201 ( 4.0A)017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.38A | 2qhcB-3u7sA:19.8 | 2qhcB-3u7sA:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 29PRO A 81VAL A 82 | None | 0.53A | 2qhcB-3uhlA:16.0 | 2qhcB-3uhlA:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b2o | YMDBPHOSPHODIESTERASE (Bacillussubtilis) |
PF13277(YmdB) | 5 | GLY A 59ALA A 60ASP A 61VAL A 9ILE A 36 | None | 0.97A | 2qhcB-4b2oA:undetectable | 2qhcB-4b2oA:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cw5 | DFNA (Bacillusvelezensis) |
PF03060(NMO) | 5 | GLY A 559GLY A 732ILE A 731PRO A 542ILE A 539 | FMN A1753 (-3.0A)NoneNoneNoneNone | 0.96A | 2qhcB-4cw5A:undetectable | 2qhcB-4cw5A:12.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dpp | DIHYDRODIPICOLINATESYNTHASE 2,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00701(DHDPS) | 5 | ASP A 83ALA A 86ASP A 89GLY A 312VAL A 317 | None | 0.96A | 2qhcB-4dppA:undetectable | 2qhcB-4dppA:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gbr | BETA-2 ADRENERGICRECEPTOR (Homo sapiens) |
PF00001(7tm_1) | 5 | VAL A 44GLY A 90ILE A 94VAL A 39ILE A 43 | None | 0.90A | 2qhcB-4gbrA:undetectable | 2qhcB-4gbrA:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gmk | RIBOSE-5-PHOSPHATEISOMERASE A (Lactobacillussalivarius) |
PF06026(Rib_5-P_isom_A) | 5 | GLY A 85ALA A 86ASP A 87ILE A 209ILE A 89 | PO4 A 301 (-3.8A)NonePO4 A 301 (-2.6A)NoneNone | 1.04A | 2qhcB-4gmkA:undetectable | 2qhcB-4gmkA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kjz | TRANSLATIONINITIATION FACTORIF-2 (Thermusthermophilus) |
PF00009(GTP_EFTU)PF04760(IF2_N)PF11987(IF-2) | 5 | GLY A 303ALA A 302VAL A 310GLY A 249VAL A 110 | None | 1.01A | 2qhcB-4kjzA:undetectable | 2qhcB-4kjzA:13.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kkm | POLYPRENYLSYNTHETASE (Zymomonasmobilis) |
PF00348(polyprenyl_synt) | 5 | ALA A 224ASP A 225ASP A 226GLY A 218ILE A 217 | None | 0.98A | 2qhcB-4kkmA:undetectable | 2qhcB-4kkmA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lde | LYSOZYME, BETA-2ADRENERGIC RECEPTOR (Escherichiavirus T4;Homo sapiens) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 5 | VAL A1044GLY A1090ILE A1094VAL A1039ILE A1043 | NoneNone1WV A1403 ( 4.1A)NoneNone | 1.02A | 2qhcB-4ldeA:undetectable | 2qhcB-4ldeA:11.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 28ASP A 29ASP A 30VAL A 32GLY A 48 | RIT A 500 (-3.6A)RIT A 500 (-3.2A)RIT A 500 (-4.8A)NoneRIT A 500 (-4.8A) | 0.63A | 2qhcB-4njvA:20.4 | 2qhcB-4njvA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30VAL A 32PRO A 81ILE A 84 | RIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 (-3.6A)RIT A 500 (-3.2A)RIT A 500 (-4.8A)NoneRIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.39A | 2qhcB-4njvA:20.4 | 2qhcB-4njvA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29VAL A 32GLY A 49PRO A 81ILE A 84 | RIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 (-3.6A)RIT A 500 (-3.2A)NoneRIT A 500 (-3.4A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.46A | 2qhcB-4njvA:20.4 | 2qhcB-4njvA:86.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28VAL A 32GLY A 49ILE A 50PRO A 81ILE A 84 | RIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 (-3.6A)NoneRIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.48A | 2qhcB-4njvA:20.4 | 2qhcB-4njvA:86.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pyr | PUTATIVEBRANCHED-CHAIN AMINOACID ABC TRANSPORTER (Chromobacteriumviolaceum) |
PF04348(LppC) | 5 | ALA A 343VAL A 88GLY A 336ILE A 337ILE A 86 | None | 0.99A | 2qhcB-4pyrA:undetectable | 2qhcB-4pyrA:13.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rwe | SUGAR-BINDINGTRANSPORT PROTEIN (Yersinia pestis) |
PF13407(Peripla_BP_4) | 5 | GLY A 196ALA A 190ILE A 223VAL A 214ILE A 156 | NoneNoneGOL A 401 ( 4.2A)NoneNone | 0.94A | 2qhcB-4rweA:undetectable | 2qhcB-4rweA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4us4 | TRANSPORTER (Bacillushalodurans) |
PF00209(SNF) | 5 | GLY A 396ALA A 93VAL A 78PRO A 332VAL A 331 | None | 0.95A | 2qhcB-4us4A:undetectable | 2qhcB-4us4A:12.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | ASP A 32GLY A 34ALA A 35ASP A 36GLY A 58 | 4B1 A 201 (-2.9A)4B1 A 201 ( 4.6A)4B1 A 201 (-3.6A)4B1 A 201 (-4.4A)4B1 A 201 (-3.4A) | 0.41A | 2qhcB-4ydfA:13.0 | 2qhcB-4ydfA:31.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | ASP A 32GLY A 34ALA A 35ASP A 36ILE A 100 | 4B1 A 201 (-2.9A)4B1 A 201 ( 4.6A)4B1 A 201 (-3.6A)4B1 A 201 (-4.4A)4B1 A 201 (-4.8A) | 0.34A | 2qhcB-4ydfA:13.0 | 2qhcB-4ydfA:31.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | ASP A 32GLY A 34ALA A 35ASP A 36VAL A 39 | 4B1 A 201 (-2.9A)4B1 A 201 ( 4.6A)4B1 A 201 (-3.6A)4B1 A 201 (-4.4A)None | 0.40A | 2qhcB-4ydfA:13.0 | 2qhcB-4ydfA:31.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z38 | MLNA (Bacillusvelezensis) |
no annotation | 5 | GLY A 576GLY A 748ILE A 747PRO A 559ILE A 556 | FMN A 900 (-3.5A)NoneNoneNoneNone | 0.95A | 2qhcB-4z38A:undetectable | 2qhcB-4z38A:13.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | GLY A 27ALA A 28ASP A 29ASP A 30ILE A 84 | None | 0.33A | 2qhcB-5b18A:18.0 | 2qhcB-5b18A:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | GLY A 27ALA A 28ASP A 29GLY A 49ILE A 84 | None | 0.60A | 2qhcB-5b18A:18.0 | 2qhcB-5b18A:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5g | PUTATIVE XANTHINEDEHYDROGENASE YAGTIRON-SULFUR-BINDINGSUBUNIT (Escherichiacoli) |
PF00111(Fer2)PF01799(Fer2_2) | 5 | GLY A 211ALA A 212ASP A 154GLY A 159ILE A 216 | NoneNoneNoneFES A 230 (-4.2A)None | 0.80A | 2qhcB-5g5gA:undetectable | 2qhcB-5g5gA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ilg | PHOTORECEPTORDEHYDROGENASE,ISOFORM C (Drosophilamelanogaster) |
PF00106(adh_short) | 5 | ASP A 232ASP A 85GLY A 174VAL A 178ILE A 131 | None | 1.03A | 2qhcB-5ilgA:undetectable | 2qhcB-5ilgA:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5irp | ALANINE RACEMASE 2 (Bacillussubtilis) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | GLY A 77ALA A 76GLY A 70ILE A 82ILE A 48 | None | 0.93A | 2qhcB-5irpA:undetectable | 2qhcB-5irpA:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1l | TOXR-ACTIVATED GENE(TAGE) (Helicobacterpylori) |
PF01551(Peptidase_M23) | 5 | GLY B 230ALA B 180VAL B 186GLY B 234ILE B 227 | None | 1.01A | 2qhcB-5j1lB:undetectable | 2qhcB-5j1lB:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jr7 | CAMP-DEPENDENTPROTEIN KINASE TYPEI-ALPHA REGULATORYSUBUNIT (Bos taurus) |
PF00027(cNMP_binding) | 5 | GLY B 199VAL B 162GLY B 223ILE B 224ILE B 163 | None | 1.06A | 2qhcB-5jr7B:undetectable | 2qhcB-5jr7B:15.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30VAL A 32GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.51A | 2qhcB-5t2zA:20.0 | 2qhcB-5t2zA:79.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tqm | CINNAMOYL-COAREDUCTASE (Sorghum bicolor) |
PF01370(Epimerase) | 5 | GLY A 127ASP A 89GLY A 38VAL A 100ILE A 96 | NoneNAP A 401 (-2.8A)NAP A 401 ( 3.2A)NoneNone | 1.04A | 2qhcB-5tqmA:undetectable | 2qhcB-5tqmA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2w | SHORT CHAINDEHYDROGENASE (Burkholderiacenocepacia) |
PF00106(adh_short) | 5 | ALA A 170ASP A 172GLY A 164ILE A 163VAL A 137 | None | 1.07A | 2qhcB-5u2wA:undetectable | 2qhcB-5u2wA:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ve3 | BPPRF (Paraburkholderiaphytofirmans) |
no annotation | 5 | GLY B 88ALA B 89ASP B 90VAL B 59ILE B 80 | None | 0.68A | 2qhcB-5ve3B:undetectable | 2qhcB-5ve3B:12.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vm2 | ALCOHOLDEHYDROGENASE (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 237ALA A 238ASP A 239VAL A 199ILE A 173 | None | 0.77A | 2qhcB-5vm2A:undetectable | 2qhcB-5vm2A:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xb7 | BETA-GALACTOSIDASE (Bifidobacteriumanimalis) |
no annotation | 5 | GLY A 376ALA A 37GLY A 383ILE A 382ILE A 39 | None | 0.96A | 2qhcB-5xb7A:undetectable | 2qhcB-5xb7A:10.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b92 | U6 SMALL NUCLEAR RNA(ADENINE-(43)-N(6))-METHYLTRANSFERASE (Homo sapiens) |
no annotation | 5 | GLY A 121ALA A 122GLY A 106VAL A 157ILE A 155 | None | 0.95A | 2qhcB-6b92A:undetectable | 2qhcB-6b92A:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cy1 | SIGNAL RECOGNITIONPARTICLE RECEPTORFTSY (Elizabethkingiaanophelis) |
no annotation | 5 | GLY A 306VAL A 266GLY A 276VAL A 294ILE A 292 | None | 0.82A | 2qhcB-6cy1A:undetectable | 2qhcB-6cy1A:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fiv | RETROPEPSIN (Felineimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 30GLY A 32ALA A 33ASP A 34GLY A 58 | 3TL A 201 (-3.5A)3TL A 201 (-3.4A)3TL A 201 (-4.0A)3TL A 201 (-3.9A)3TL A 201 (-3.4A) | 0.28A | 2qhcB-6fivA:15.4 | 2qhcB-6fivA:29.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fiv | RETROPEPSIN (Felineimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 30GLY A 32ALA A 33ASP A 34VAL A 99 | 3TL A 201 (-3.5A)3TL A 201 (-3.4A)3TL A 201 (-4.0A)3TL A 201 (-3.9A)None | 0.43A | 2qhcB-6fivA:15.4 | 2qhcB-6fivA:29.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 8 | ARG A 8ASP A 25GLY A 27ASP A 29ASP A 30GLY A 49ILE A 50ILE A 84 | NoneNIU A 100 (-2.8A)NIU A 100 (-4.5A)NoneNoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)None | 0.67A | 2qhcB-6upjA:17.9 | 2qhcB-6upjA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-4.5A)NIU A 100 (-3.6A)NoneNoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)NoneNone | 0.65A | 2qhcB-6upjA:17.9 | 2qhcB-6upjA:48.48 |