SIMILAR PATTERNS OF AMINO ACIDS FOR 2QEU_A_ACTA142

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 357
PRO A 356
ILE A 415
GLY A 416
 None
 1.19A 2qeuA-1ebdA:
undetectable
2qeuC-1ebdA:
0.1		 2qeuA-1ebdA:
13.41
2qeuC-1ebdA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eif EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A

(Methanocaldococcus
jannaschii) 		PF01287
(eIF-5a)
PF08207
(EFP_N) 		4 GLU A  55
PRO A  27
ILE A  53
GLY A  52
 None
 1.10A 2qeuA-1eifA:
undetectable
2qeuC-1eifA:
undetectable		 2qeuA-1eifA:
22.22
2qeuC-1eifA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN

(Thermococcus
litoralis) 		PF01547
(SBP_bac_1) 		4 GLU A  17
PRO A  15
ILE A  18
GLY A  13
 TRE  A 563 (-2.9A)
None
None
TRE  A 563 (-3.1A)
 1.14A 2qeuA-1eu8A:
0.0
2qeuC-1eu8A:
0.0		 2qeuA-1eu8A:
16.54
2qeuC-1eu8A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 PRO A 234
ILE A 233
GLY A 232
LYS A 225
 None
 1.07A 2qeuA-1fw8A:
0.0
2qeuC-1fw8A:
0.0		 2qeuA-1fw8A:
17.51
2qeuC-1fw8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		4 GLU A 347
PRO A 349
ILE A 348
GLY A 321
 None
 1.07A 2qeuA-1hlgA:
0.0
2qeuC-1hlgA:
0.0		 2qeuA-1hlgA:
17.30
2qeuC-1hlgA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwp EBULIN

(Sambucus ebulus) 		PF00652
(Ricin_B_lectin) 		4 GLU B 157
ILE B 206
GLY B 156
LYS B 208
 None
 1.08A 2qeuA-1hwpB:
undetectable
2qeuC-1hwpB:
undetectable		 2qeuA-1hwpB:
19.47
2qeuC-1hwpB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ln0 INTRON-ASSOCIATED
ENDONUCLEASE 1

(Escherichia
virus T4) 		PF01541
(GIY-YIG) 		4 GLU A  63
PRO A  65
ILE A  64
GLY A   4
 None
 1.18A 2qeuA-1ln0A:
undetectable
2qeuC-1ln0A:
undetectable		 2qeuA-1ln0A:
16.67
2qeuC-1ln0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnq POTASSIUM CHANNEL
RELATED PROTEIN

(Methanothermobacter
thermautotrophicus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		4 GLU A 326
PRO A 324
ILE A 327
GLY A 322
 None
 1.12A 2qeuA-1lnqA:
undetectable
2qeuC-1lnqA:
undetectable		 2qeuA-1lnqA:
16.67
2qeuC-1lnqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 GLU A 347
PRO A 350
ILE A 351
GLY A 348
 152  A5001 (-4.0A)
None
None
None
 1.07A 2qeuA-1ndfA:
0.0
2qeuC-1ndfA:
0.0		 2qeuA-1ndfA:
11.54
2qeuC-1ndfA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnl L-3-PHOSPHOSERINE
PHOSPHATASE

(Homo sapiens) 		PF00702
(Hydrolase) 		4 GLU A  33
ILE A  31
GLY A  30
LYS A  36
 None
None
CL  A1505 (-3.3A)
None
 1.09A 2qeuA-1nnlA:
undetectable
2qeuC-1nnlA:
undetectable		 2qeuA-1nnlA:
22.71
2qeuC-1nnlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oae CYTOCHROME C'

(Methylophilus
methylotrophus) 		PF09086
(DUF1924) 		4 GLU A  69
PRO A  71
ILE A  70
GLY A  61
 None
HEC  A1125 (-4.2A)
HEC  A1125 (-4.4A)
None
 1.09A 2qeuA-1oaeA:
undetectable
2qeuC-1oaeA:
undetectable		 2qeuA-1oaeA:
21.23
2qeuC-1oaeA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 GLU A 149
ILE A 147
GLY A 146
LYS A 152
 None
 1.04A 2qeuA-1px8A:
0.0
2qeuC-1px8A:
0.0		 2qeuA-1px8A:
16.39
2qeuC-1px8A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 PRO A 305
ILE A 304
GLY A 303
LYS A 296
 None
 1.17A 2qeuA-1qpgA:
1.6
2qeuC-1qpgA:
0.5		 2qeuA-1qpgA:
18.90
2qeuC-1qpgA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9k NUCLEAR FACTOR OF
ACTIVATED T-CELLS,
CYTOPLASMIC 2

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 GLU C 641
PRO C 643
ILE C 642
GLY C 593
 None
 1.13A 2qeuA-1s9kC:
undetectable
2qeuC-1s9kC:
undetectable		 2qeuA-1s9kC:
22.94
2qeuC-1s9kC:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLU E 439
ILE E 440
GLY E 436
LYS E 444
 None
 1.11A 2qeuA-1skyE:
0.0
2qeuC-1skyE:
undetectable		 2qeuA-1skyE:
16.00
2qeuC-1skyE:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		4 GLU A 201
PRO A 203
ILE A 202
GLY A 190
 None
 1.17A 2qeuA-1u2xA:
0.8
2qeuC-1u2xA:
undetectable		 2qeuA-1u2xA:
14.01
2qeuC-1u2xA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLU B  79
PRO B  78
ILE B  62
GLY B  27
 None
 1.11A 2qeuA-1w85B:
undetectable
2qeuC-1w85B:
undetectable		 2qeuA-1w85B:
19.57
2qeuC-1w85B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		4 GLU A 351
PRO A 350
ILE A 353
GLY A 352
 None
 1.10A 2qeuA-1wstA:
undetectable
2qeuC-1wstA:
undetectable		 2qeuA-1wstA:
16.59
2qeuC-1wstA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		4 GLU A 310
PRO A 317
ILE A 311
GLY A 315
 None
 0.93A 2qeuA-1x3lA:
undetectable
2qeuC-1x3lA:
undetectable		 2qeuA-1x3lA:
16.59
2qeuC-1x3lA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xma PREDICTED
TRANSCRIPTIONAL
REGULATOR

(Ruminiclostridium
thermocellum) 		PF03551
(PadR) 		4 GLU A  82
PRO A  81
ILE A  84
GLY A  83
 None
 0.78A 2qeuA-1xmaA:
undetectable
2qeuC-1xmaA:
undetectable		 2qeuA-1xmaA:
22.29
2qeuC-1xmaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 4 GLU B 342
PRO B 341
ILE B 377
GLY B 378
 None
 0.94A 2qeuA-1xnjB:
undetectable
2qeuC-1xnjB:
1.5		 2qeuA-1xnjB:
12.87
2qeuC-1xnjB:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		4 GLU A 163
PRO A 258
ILE A 251
GLY A 256
 CA  A 701 (-3.3A)
None
None
None
 1.09A 2qeuA-1yleA:
undetectable
2qeuC-1yleA:
undetectable		 2qeuA-1yleA:
20.47
2qeuC-1yleA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z INTERCELLULAR
ADHESION MOLECULE-1

(Homo sapiens) 		PF03921
(ICAM_N) 		4 GLU I 416
PRO I 390
ILE I 414
GLY I 415
 None
 0.92A 2qeuA-1z7zI:
undetectable
2qeuC-1z7zI:
undetectable		 2qeuA-1z7zI:
14.77
2qeuC-1z7zI:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		4 GLU A 321
PRO A 323
ILE A 322
GLY A 336
 None
 1.13A 2qeuA-1zzgA:
undetectable
2qeuC-1zzgA:
undetectable		 2qeuA-1zzgA:
16.95
2qeuC-1zzgA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwj PUTATIVE
ENDONUCLEASE

(Aeropyrum
pernix) 		PF01042
(Ribonuc_L-PSP) 		4 PRO A  31
ILE A  29
GLY A  34
LYS A   6
 None
 1.17A 2qeuA-2cwjA:
undetectable
2qeuC-2cwjA:
undetectable		 2qeuA-2cwjA:
25.17
2qeuC-2cwjA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpa PROTEIN (ACID
PHOSPHATASE)

(Homo sapiens) 		PF00328
(His_Phos_2) 		4 GLU A1095
PRO A1094
ILE A1099
GLY A1096
 None
 1.17A 2qeuA-2hpaA:
undetectable
2qeuC-2hpaA:
undetectable		 2qeuA-2hpaA:
17.15
2qeuC-2hpaA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		4 GLU A  14
PRO A  16
ILE A  15
GLY A  38
 None
 1.13A 2qeuA-2hpwA:
undetectable
2qeuC-2hpwA:
undetectable		 2qeuA-2hpwA:
21.61
2qeuC-2hpwA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		4 GLU A  96
PRO A  97
ILE A  92
GLY A  93
 None
 1.16A 2qeuA-2jfqA:
undetectable
2qeuC-2jfqA:
undetectable		 2qeuA-2jfqA:
20.15
2qeuC-2jfqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kue SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		PF03793
(PASTA) 		4 PRO A 498
ILE A 497
GLY A 542
LYS A 495
 None
 1.13A 2qeuA-2kueA:
undetectable
2qeuC-2kueA:
undetectable		 2qeuA-2kueA:
21.38
2qeuC-2kueA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m47 UNCHARACTERIZED
PROTEIN CGL2373

(Corynebacterium
glutamicum) 		PF10604
(Polyketide_cyc2) 		4 GLU A 143
PRO A 142
ILE A 141
GLY A 140
 None
 1.20A 2qeuA-2m47A:
undetectable
2qeuC-2m47A:
undetectable		 2qeuA-2m47A:
20.83
2qeuC-2m47A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 GLU A 188
PRO A 197
ILE A 196
GLY A 189
 None
 1.15A 2qeuA-2p2mA:
undetectable
2qeuC-2p2mA:
undetectable		 2qeuA-2p2mA:
12.52
2qeuC-2p2mA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00483
(NTP_transferase) 		4 PRO A 141
ILE A  46
GLY A  45
LYS A  35
 UPG  A 326 (-4.2A)
None
None
UPG  A 326 (-3.0A)
 0.95A 2qeuA-2pa4A:
undetectable
2qeuC-2pa4A:
undetectable		 2qeuA-2pa4A:
19.94
2qeuC-2pa4A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE

(Azospirillum
brasilense) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLU A 162
PRO A 164
ILE A 163
GLY A  98
 None
 1.14A 2qeuA-2q5oA:
2.2
2qeuC-2q5oA:
undetectable		 2qeuA-2q5oA:
13.98
2qeuC-2q5oA:
13.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE

(Paraburkholderia
xenovorans) 		PF02627
(CMD) 		4 GLU A  80
PRO A  81
ILE A  82
GLY A  83
 CIT  A 146 ( 3.0A)
ACT  A 142 (-3.5A)
ACT  A 142 (-3.9A)
ACT  A 142 ( 3.1A)
 0.00A 2qeuA-2qeuA:
26.9
2qeuC-2qeuA:
25.2		 2qeuA-2qeuA:
100.00
2qeuC-2qeuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 GLU A 342
PRO A 341
ILE A 377
GLY A 378
 None
 0.97A 2qeuA-2qjfA:
undetectable
2qeuC-2qjfA:
undetectable		 2qeuA-2qjfA:
17.75
2qeuC-2qjfA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Streptococcus
mutans) 		PF01182
(Glucosamine_iso) 		4 GLU A  63
PRO A  95
ILE A 172
GLY A  97
 None
 1.12A 2qeuA-2ri0A:
undetectable
2qeuC-2ri0A:
undetectable		 2qeuA-2ri0A:
21.37
2qeuC-2ri0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		4 GLU A 245
PRO A 240
ILE A 244
GLY A 243
 None
 1.11A 2qeuA-2rjbA:
undetectable
2qeuC-2rjbA:
undetectable		 2qeuA-2rjbA:
13.87
2qeuC-2rjbA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		4 GLU A  32
PRO A  33
ILE A  36
GLY A  35
 None
 0.82A 2qeuA-2vlcA:
undetectable
2qeuC-2vlcA:
undetectable		 2qeuA-2vlcA:
14.50
2qeuC-2vlcA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		4 GLU A  12
PRO A  10
ILE A  13
GLY A   8
 None
 1.20A 2qeuA-2x1cA:
undetectable
2qeuC-2x1cA:
undetectable		 2qeuA-2x1cA:
18.21
2qeuC-2x1cA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8p CHOLINE-BINDING
PROTEIN F

(Streptococcus
pneumoniae) 		PF01473
(CW_binding_1) 		4 GLU A 158
PRO A 155
ILE A 156
GLY A 157
 None
None
GOL  A1316 (-4.4A)
None
 1.18A 2qeuA-2x8pA:
undetectable
2qeuC-2x8pA:
undetectable		 2qeuA-2x8pA:
19.33
2qeuC-2x8pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zt9 CYTOCHROME B6

(Nostoc sp. PCC
7120) 		PF00033
(Cytochrome_B) 		4 GLU A 156
PRO A 155
ILE A 165
GLY A 162
 None
 1.15A 2qeuA-2zt9A:
undetectable
2qeuC-2zt9A:
undetectable		 2qeuA-2zt9A:
20.83
2qeuC-2zt9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 GLU A 331
PRO A 330
ILE A 333
GLY A 332
 None
 1.09A 2qeuA-3a8kA:
undetectable
2qeuC-3a8kA:
undetectable		 2qeuA-3a8kA:
18.87
2qeuC-3a8kA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens) 		PF01875
(Memo) 		4 GLU A 166
PRO A 248
ILE A 249
GLY A 250
 GOL  A 303 (-3.7A)
None
None
GOL  A 303 ( 4.4A)
 1.01A 2qeuA-3bczA:
undetectable
2qeuC-3bczA:
undetectable		 2qeuA-3bczA:
20.41
2qeuC-3bczA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 GLU B 210
PRO B 229
ILE B 227
GLY B 208
 None
 1.13A 2qeuA-3bvhB:
undetectable
2qeuC-3bvhB:
undetectable		 2qeuA-3bvhB:
17.91
2qeuC-3bvhB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cty THIOREDOXIN
REDUCTASE

(Thermoplasma
acidophilum) 		PF07992
(Pyr_redox_2) 		4 GLU A 215
ILE A 216
GLY A 133
LYS A 227
 None
 1.15A 2qeuA-3ctyA:
undetectable
2qeuC-3ctyA:
undetectable		 2qeuA-3ctyA:
19.87
2qeuC-3ctyA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 335
PRO A 334
ILE A 158
GLY A 336
 None
 0.95A 2qeuA-3cyjA:
undetectable
2qeuC-3cyjA:
undetectable		 2qeuA-3cyjA:
19.61
2qeuC-3cyjA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 335
PRO A 334
ILE A 158
GLY A 337
 None
 1.04A 2qeuA-3cyjA:
undetectable
2qeuC-3cyjA:
undetectable		 2qeuA-3cyjA:
19.61
2qeuC-3cyjA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f44 PUTATIVE
MONOOXYGENASE

(Lactobacillus
acidophilus) 		PF03992
(ABM) 		4 GLU A  57
ILE A  58
GLY A  44
LYS A  10
 None
 1.05A 2qeuA-3f44A:
undetectable
2qeuC-3f44A:
undetectable		 2qeuA-3f44A:
20.26
2qeuC-3f44A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f59 ANKYRIN-1

(Homo sapiens) 		PF00791
(ZU5) 		4 GLU A1038
PRO A 939
ILE A 938
GLY A 924
 None
 0.88A 2qeuA-3f59A:
undetectable
2qeuC-3f59A:
undetectable		 2qeuA-3f59A:
22.73
2qeuC-3f59A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLU A 103
PRO A 102
ILE A 107
GLY A 106
 None
 1.04A 2qeuA-3fefA:
undetectable
2qeuC-3fefA:
undetectable		 2qeuA-3fefA:
17.07
2qeuC-3fefA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 GLU A1156
PRO A1158
ILE A1157
GLY A1161
 None
 1.20A 2qeuA-3hmjA:
2.3
2qeuC-3hmjA:
3.5		 2qeuA-3hmjA:
6.06
2qeuC-3hmjA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 GLU A 183
PRO A 181
ILE A 182
GLY A 235
 None
 1.19A 2qeuA-3j2iA:
undetectable
2qeuC-3j2iA:
undetectable		 2qeuA-3j2iA:
16.97
2qeuC-3j2iA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S11,
MITOCHONDRIAL

(Bos taurus) 		PF00411
(Ribosomal_S11) 		4 GLU K  84
PRO K  70
ILE K  69
GLY K  71
 None
 1.18A 2qeuA-3jd5K:
undetectable
2qeuC-3jd5K:
undetectable		 2qeuA-3jd5K:
21.60
2qeuC-3jd5K:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans) 		PF01039
(Carboxyl_trans) 		4 GLU B 385
PRO B 387
ILE B 386
LYS B 285
 None
 1.16A 2qeuA-3n6rB:
undetectable
2qeuC-3n6rB:
undetectable		 2qeuA-3n6rB:
14.34
2qeuC-3n6rB:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p43 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Methanosarcina
barkeri) 		PF13298
(LigD_N) 		4 GLU A  88
PRO A  90
ILE A  89
GLY A  97
 None
 1.10A 2qeuA-3p43A:
undetectable
2qeuC-3p43A:
undetectable		 2qeuA-3p43A:
26.51
2qeuC-3p43A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE

(Pyrobaculum
neutrophilum) 		PF01950
(FBPase_3) 		4 GLU A 135
PRO A 136
ILE A 201
GLY A 137
 None
 1.00A 2qeuA-3t2cA:
undetectable
2qeuC-3t2cA:
undetectable		 2qeuA-3t2cA:
17.07
2qeuC-3t2cA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 GLU A 368
PRO A 304
ILE A 365
GLY A 369
 None
 1.15A 2qeuA-3ummA:
undetectable
2qeuC-3ummA:
undetectable		 2qeuA-3ummA:
7.27
2qeuC-3ummA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		PF09481
(CRISPR_Cse1) 		4 GLU A  70
PRO A  69
ILE A  66
GLY A  67
 None
 0.77A 2qeuA-3wvoA:
2.4
2qeuC-3wvoA:
2.5		 2qeuA-3wvoA:
15.27
2qeuC-3wvoA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyd LC-EST1C

(uncultured
organism) 		PF00326
(Peptidase_S9) 		4 GLU A 473
PRO A 475
ILE A 474
GLY A 444
 None
 1.07A 2qeuA-3wydA:
undetectable
2qeuC-3wydA:
undetectable		 2qeuA-3wydA:
20.70
2qeuC-3wydA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 168
PRO A 170
ILE A 169
GLY A 121
 None
 0.88A 2qeuA-3zx1A:
undetectable
2qeuC-3zx1A:
undetectable		 2qeuA-3zx1A:
16.49
2qeuC-3zx1A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16415
(CNOT1_CAF1_bind) 		4 GLU A 964
PRO A 995
ILE A 963
LYS A 968
 None
 1.07A 2qeuA-4b8aA:
undetectable
2qeuC-4b8aA:
1.5		 2qeuA-4b8aA:
19.42
2qeuC-4b8aA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE

(Ralstonia sp.
DSMZ 6428) 		PF13561
(adh_short_C2) 		4 GLU A 219
PRO A 217
ILE A 183
GLY A 215
 None
None
NAP  A1250 (-4.8A)
None
 1.20A 2qeuA-4bmsA:
undetectable
2qeuC-4bmsA:
undetectable		 2qeuA-4bmsA:
23.69
2qeuC-4bmsA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Corynebacterium
glutamicum) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		5 GLU A 254
PRO A 256
ILE A 255
GLY A 259
LYS A 191
 None
 1.48A 2qeuA-4dbhA:
undetectable
2qeuC-4dbhA:
undetectable		 2qeuA-4dbhA:
22.87
2qeuC-4dbhA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 GLU A 828
PRO A 827
ILE A 830
GLY A 829
 None
 1.07A 2qeuA-4ecoA:
undetectable
2qeuC-4ecoA:
undetectable		 2qeuA-4ecoA:
11.60
2qeuC-4ecoA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fer EXPANSIN-YOAJ

(Bacillus
subtilis) 		PF03330
(DPBB_1) 		4 GLU A  59
PRO A  61
ILE A  91
GLY A  63
 None
 1.09A 2qeuA-4ferA:
undetectable
2qeuC-4ferA:
undetectable		 2qeuA-4ferA:
22.75
2qeuC-4ferA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 GLU A 494
PRO A 496
ILE A 495
GLY A 527
 None
 1.09A 2qeuA-4fusA:
1.1
2qeuC-4fusA:
undetectable		 2qeuA-4fusA:
10.95
2qeuC-4fusA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt8 SENSOR PROTEIN VRAS

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		4 GLU A 250
PRO A 246
ILE A 249
GLY A 248
 None
 1.20A 2qeuA-4gt8A:
undetectable
2qeuC-4gt8A:
undetectable		 2qeuA-4gt8A:
21.85
2qeuC-4gt8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		4 GLU A  87
PRO A 281
ILE A 280
GLY A  88
 None
 1.11A 2qeuA-4j7hA:
undetectable
2qeuC-4j7hA:
undetectable		 2qeuA-4j7hA:
14.93
2qeuC-4j7hA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0r CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 GLU A 452
PRO A 451
ILE A 454
GLY A 453
 None
 1.15A 2qeuA-4k0rA:
0.6
2qeuC-4k0rA:
0.8		 2qeuA-4k0rA:
13.32
2qeuC-4k0rA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		4 GLU A 456
ILE A 438
GLY A 439
LYS A 435
 None
 1.16A 2qeuA-4mh1A:
undetectable
2qeuC-4mh1A:
undetectable		 2qeuA-4mh1A:
14.56
2qeuC-4mh1A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfa PROTEIN CASC5

(Homo sapiens) 		no annotation 4 GLU A2216
ILE A2217
GLY A2214
LYS A2298
 None
 1.08A 2qeuA-4nfaA:
undetectable
2qeuC-4nfaA:
undetectable		 2qeuA-4nfaA:
18.50
2qeuC-4nfaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		4 GLU A 235
PRO A 237
ILE A 236
GLY A 240
 None
 0.87A 2qeuA-4nnbA:
1.0
2qeuC-4nnbA:
1.1		 2qeuA-4nnbA:
14.84
2qeuC-4nnbA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 GLU A 386
PRO A 387
ILE A 220
GLY A 385
 None
 1.20A 2qeuA-4p72A:
undetectable
2qeuC-4p72A:
undetectable		 2qeuA-4p72A:
11.11
2qeuC-4p72A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 GLU A 282
PRO A 283
ILE A 284
GLY A 239
 MRD  A 501 (-2.7A)
None
None
None
 0.78A 2qeuA-4qfuA:
undetectable
2qeuC-4qfuA:
undetectable		 2qeuA-4qfuA:
15.78
2qeuC-4qfuA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305

(Thermoplasma
acidophilum) 		no annotation 4 GLU A 318
PRO A 317
ILE A   6
GLY A   7
 None
 1.02A 2qeuA-4rkzA:
undetectable
2qeuC-4rkzA:
undetectable		 2qeuA-4rkzA:
17.37
2qeuC-4rkzA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran) 		4 GLU A 224
PRO A 222
ILE A 225
GLY A 220
 None
 1.13A 2qeuA-4u02A:
undetectable
2qeuC-4u02A:
undetectable		 2qeuA-4u02A:
19.26
2qeuC-4u02A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhp BACTERIOCIN IMMUNITY
PROTEIN

(Pseudomonas
aeruginosa) 		PF01320
(Colicin_Pyocin) 		4 GLU B  69
PRO B  68
ILE B  71
GLY B  70
 None
 0.96A 2qeuA-4uhpB:
undetectable
2qeuC-4uhpB:
undetectable		 2qeuA-4uhpB:
24.29
2qeuC-4uhpB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuo CYTOSOLIC MALATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLU A 274
PRO A 275
ILE A 278
GLY A 277
 None
 0.84A 2qeuA-4uuoA:
undetectable
2qeuC-4uuoA:
undetectable		 2qeuA-4uuoA:
19.30
2qeuC-4uuoA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Burkholderia
thailandensis) 		PF01467
(CTP_transf_like) 		4 GLU A 105
PRO A  65
ILE A 106
GLY A  67
 NAD  A 301 ( 4.3A)
None
None
None
 1.18A 2qeuA-4wsoA:
undetectable
2qeuC-4wsoA:
undetectable		 2qeuA-4wsoA:
20.87
2qeuC-4wsoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 4 GLU A 227
PRO A 194
ILE A 193
GLY A 228
 None
 0.93A 2qeuA-4xn3A:
undetectable
2qeuC-4xn3A:
undetectable		 2qeuA-4xn3A:
12.65
2qeuC-4xn3A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLU A 407
PRO A 409
ILE A 408
LYS A 370
 None
 1.09A 2qeuA-4yswA:
2.1
2qeuC-4yswA:
0.9		 2qeuA-4yswA:
7.38
2qeuC-4yswA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2

(Mycolicibacterium
smegmatis) 		PF03971
(IDH) 		4 GLU A 430
PRO A 432
ILE A 431
GLY A 456
 None
 1.07A 2qeuA-4zdaA:
undetectable
2qeuC-4zdaA:
undetectable		 2qeuA-4zdaA:
12.29
2qeuC-4zdaA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmo HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Neisseria
meningitidis) 		PF01648
(ACPS) 		4 GLU A  87
PRO A  86
ILE A  78
GLY A  79
 None
 1.04A 2qeuA-5cmoA:
undetectable
2qeuC-5cmoA:
undetectable		 2qeuA-5cmoA:
23.65
2qeuC-5cmoA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmp UNCHARACTERIZED
PROTEIN

(Methanocella
paludicola) 		PF13298
(LigD_N) 		4 GLU A  95
PRO A  94
ILE A  93
GLY A 100
 None
 1.17A 2qeuA-5dmpA:
undetectable
2qeuC-5dmpA:
undetectable		 2qeuA-5dmpA:
23.66
2qeuC-5dmpA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 GLU A 288
PRO A 289
ILE A 398
GLY A 258
 None
 1.12A 2qeuA-5dotA:
undetectable
2qeuC-5dotA:
undetectable		 2qeuA-5dotA:
6.28
2qeuC-5dotA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7s LON PROTEASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C) 		4 GLU A 705
PRO A 714
ILE A 715
GLY A 704
 None
 1.19A 2qeuA-5e7sA:
undetectable
2qeuC-5e7sA:
undetectable		 2qeuA-5e7sA:
19.05
2qeuC-5e7sA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus) 		PF07738
(Sad1_UNC) 		4 GLU A 696
PRO A 697
ILE A 601
GLY A 695
 None
 1.19A 2qeuA-5ed8A:
undetectable
2qeuC-5ed8A:
undetectable		 2qeuA-5ed8A:
23.14
2qeuC-5ed8A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLU A2069
PRO A2068
ILE A2071
GLY A2070
 None
 1.12A 2qeuA-5i6gA:
2.2
2qeuC-5i6gA:
2.2		 2qeuA-5i6gA:
9.21
2qeuC-5i6gA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLU A2069
PRO A2068
ILE A2071
GLY A2070
 None
 1.08A 2qeuA-5i6hA:
undetectable
2qeuC-5i6hA:
undetectable		 2qeuA-5i6hA:
7.65
2qeuC-5i6hA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 GLU A2069
PRO A2068
ILE A2071
GLY A2070
 None
 1.11A 2qeuA-5i6iA:
undetectable
2qeuC-5i6iA:
3.1		 2qeuA-5i6iA:
5.20
2qeuC-5i6iA:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 GLU L 184
PRO L 189
ILE L 194
GLY L 191
 FAD  L 503 (-2.1A)
None
None
FAD  L 503 (-2.6A)
 1.17A 2qeuA-5jfcL:
undetectable
2qeuC-5jfcL:
undetectable		 2qeuA-5jfcL:
16.59
2qeuC-5jfcL:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		4 GLU A 168
PRO A 182
ILE A 180
GLY A 169
 None
 1.19A 2qeuA-5kkgA:
0.7
2qeuC-5kkgA:
undetectable		 2qeuA-5kkgA:
14.65
2qeuC-5kkgA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		4 GLU A 430
PRO A 432
ILE A 431
GLY A 456
 None
 1.11A 2qeuA-5kvuA:
undetectable
2qeuC-5kvuA:
undetectable		 2qeuA-5kvuA:
12.50
2qeuC-5kvuA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 GLU A 284
PRO A 285
ILE A 286
GLY A 241
 NH3  A 504 (-4.4A)
None
None
None
 0.80A 2qeuA-5msyA:
undetectable
2qeuC-5msyA:
undetectable		 2qeuA-5msyA:
14.97
2qeuC-5msyA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu9 ACCUMULATION
ASSOCIATED PROTEIN
AAP G58-SPACER-G513
(VARIANT
G5-SPACER-CONSENSUS
G5)

(Staphylococcus
epidermidis) 		PF07501
(G5)
PF17041
(SasG_E) 		4 GLU A  11
PRO A  13
ILE A  12
GLY A  38
 None
 0.86A 2qeuA-5tu9A:
undetectable
2qeuC-5tu9A:
undetectable		 2qeuA-5tu9A:
18.40
2qeuC-5tu9A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 4 GLU A 242
PRO A 248
ILE A 247
GLY A 243
 None
 1.11A 2qeuA-5whsA:
undetectable
2qeuC-5whsA:
1.9		 2qeuA-5whsA:
undetectable
2qeuC-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE

(Escherichia
coli) 		no annotation 4 PRO C 412
ILE C 411
GLY C 408
LYS C 439
 None
 1.06A 2qeuA-5wqlC:
undetectable
2qeuC-5wqlC:
undetectable		 2qeuA-5wqlC:
12.46
2qeuC-5wqlC:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 GLU A 257
PRO A 255
ILE A 258
GLY A 253
 None
 1.15A 2qeuA-5x7sA:
undetectable
2qeuC-5x7sA:
undetectable		 2qeuA-5x7sA:
8.59
2qeuC-5x7sA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 PRO A 488
ILE A 487
GLY A 518
LYS A 478
 None
 0.90A 2qeuA-5yj6A:
undetectable
2qeuC-5yj6A:
undetectable		 2qeuA-5yj6A:
undetectable
2qeuC-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Zea mays) 		no annotation 4 PRO 1  64
ILE 1 193
GLY 1  65
LYS 1  85
 None
None
CLA  1 602 (-4.6A)
None
 1.18A 2qeuA-5zji1:
undetectable
2qeuC-5zji1:
undetectable		 2qeuA-5zji1:
undetectable
2qeuC-5zji1:
undetectable