SIMILAR PATTERNS OF AMINO ACIDS FOR 2QEB_B_HSMB145

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a41 TOPOISOMERASE I

(Vaccinia virus) 		PF01028
(Topoisom_I) 		4 ILE A 279
TYR A 274
PHE A  88
ASP A  85
 None
 0.89A 2qebB-1a41A:
0.0		 2qebB-1a41A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6j NITROGEN REGULATORY
IIA PROTEIN

(Escherichia
coli) 		PF00359
(PTS_EIIA_2) 		4 ILE A  65
PHE A  96
ASP A  97
GLU A  58
 None
 1.11A 2qebB-1a6jA:
0.0		 2qebB-1a6jA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4j ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE L 106
TYR L  12
TYR L 140
GLU L 165
 None
 1.16A 2qebB-1b4jL:
undetectable		 2qebB-1b4jL:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8n COAT PROTEIN

(unidentified
tobacco
necrosis virus) 		PF00729
(Viral_coat) 		4 ILE A 115
TYR A 217
PHE A 212
ASP A 213
 None
 0.95A 2qebB-1c8nA:
undetectable		 2qebB-1c8nA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8f BENZYL ALCOHOL
DEHYDROGENASE

(Acinetobacter
calcoaceticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A  26
ARG A  27
ASP A 120
GLU A  33
 None
 1.08A 2qebB-1f8fA:
0.0		 2qebB-1f8fA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 ILE A 132
ARG A 131
TYR A 116
GLU A 187
 None
ADP  A1100 ( 4.0A)
None
ADP  A1100 (-4.6A)
 1.07A 2qebB-1g8xA:
undetectable		 2qebB-1g8xA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ILE A 226
ARG A 227
TYR A 231
GLU A 164
 None
 1.01A 2qebB-1gq2A:
0.0		 2qebB-1gq2A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 ARG A 125
TYR A 126
ASP A 109
GLU A  54
 None
 1.13A 2qebB-1j1wA:
undetectable		 2qebB-1j1wA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		4 TYR A  23
PHE A 241
ASP A 190
GLU A 192
 None
GOL  A 530 (-4.8A)
None
GOL  A 530 (-3.9A)
 1.00A 2qebB-1kfwA:
0.0		 2qebB-1kfwA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ARG A 344
TYR A 246
PHE A 284
GLU A 283
 None
 1.04A 2qebB-1kt8A:
0.0		 2qebB-1kt8A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aquifex
aeolicus) 		PF01791
(DeoC) 		4 ILE A 108
ARG A 300
ASP A 188
GLU A 186
 None
 0.92A 2qebB-1mzhA:
undetectable		 2qebB-1mzhA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd N15 ALPHA-BETA
T-CELL RECEPTOR

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF09291
(DUF1968) 		4 ILE A 181
ARG B 195
PHE A 146
ASP A 145
 None
 1.01A 2qebB-1nfdA:
undetectable		 2qebB-1nfdA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 ILE A 183
ARG A 184
PHE A 147
GLU A 171
 None
 1.14A 2qebB-1nsaA:
0.7		 2qebB-1nsaA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt4 GLUCOSE-1-PHOSPHATAS
E

(Escherichia
coli) 		PF00328
(His_Phos_2) 		4 ILE A 293
ARG A  17
TYR A 305
GLU A 312
 None
G1P  A2000 (-4.0A)
None
None
 1.08A 2qebB-1nt4A:
undetectable		 2qebB-1nt4A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN

(Escherichia
coli) 		PF03872
(RseA_N)
PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2) 		5 ARG C  40
TYR A  29
TYR A  75
ASP A   7
GLU A   3
 None
 1.23A 2qebB-1or7C:
undetectable		 2qebB-1or7C:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 ILE A  38
ARG A  39
TYR A 105
ASP A  27
 None
 0.91A 2qebB-1qe0A:
undetectable		 2qebB-1qe0A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 ILE A   7
ARG A 201
ASP A  89
GLU A  87
 None
None
HPD  A 801 ( 4.6A)
None
 1.01A 2qebB-1ub3A:
undetectable		 2qebB-1ub3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus) 		PF00079
(Serpin) 		4 ILE A  53
ARG A  50
PHE A  65
GLU A  70
 None
 0.97A 2qebB-1uhgA:
undetectable		 2qebB-1uhgA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE

(Human
alphaherpesvirus
3) 		PF00716
(Peptidase_S21) 		4 ILE A 228
TYR A  18
PHE A  72
ASP A  67
 None
 1.05A 2qebB-1vzvA:
undetectable		 2qebB-1vzvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp5 TOPOISOMERASE IV

(Geobacillus
stearothermophilus) 		PF03989
(DNA_gyraseA_C) 		4 ILE A 249
ARG A 248
TYR A 166
GLU A 241
 None
 0.65A 2qebB-1wp5A:
undetectable		 2qebB-1wp5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 ILE A 288
TYR A 289
PHE A 344
ASP A 345
 None
 1.02A 2qebB-1zb7A:
undetectable		 2qebB-1zb7A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 ILE A 183
ARG A 184
PHE A 147
GLU A 171
 None
 1.02A 2qebB-1zliA:
undetectable		 2qebB-1zliA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		5 ILE A 363
ARG A 362
TYR A 264
PHE A 302
GLU A 301
 None
 1.00A 2qebB-2abjA:
undetectable		 2qebB-2abjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 287
TYR A 288
PHE A 344
ASP A 345
 None
 1.09A 2qebB-2np0A:
undetectable		 2qebB-2np0A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		4 ILE A  72
TYR A  76
PHE A 109
ASP A 110
 None
 0.90A 2qebB-2o3eA:
undetectable		 2qebB-2o3eA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6s VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF11921
(DUF3439)
PF12799
(LRR_4)
PF13855
(LRR_8) 		4 ILE A 197
TYR A 192
PHE A 167
ASP A 168
 None
 1.14A 2qebB-2o6sA:
undetectable		 2qebB-2o6sA:
18.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pql D7R4 PROTEIN

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		7 ILE A  21
ARG A  22
TYR A  24
TYR A  94
PHE A 110
ASP A 111
GLU A 114
 TSS  A 145 (-4.8A)
TSS  A 145 (-3.5A)
TSS  A 145 (-3.4A)
None
TSS  A 145 (-4.4A)
TSS  A 145 (-3.5A)
TSS  A 145 (-3.6A)
 0.34A 2qebB-2pqlA:
29.0		 2qebB-2pqlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 ILE A 467
ARG A 169
PHE A 456
ASP A 471
 None
 1.06A 2qebB-2tohA:
undetectable		 2qebB-2tohA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa0 APOPTOSIS REGULATOR
BCL-2

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 ILE A  19
TYR A  21
ASP A 102
GLU A 152
 None
 1.14A 2qebB-2xa0A:
undetectable		 2qebB-2xa0A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		4 TYR A 404
PHE A 329
ASP A 362
GLU A 287
 None
2A3  A 602 (-3.8A)
2A3  A 602 (-3.8A)
2A3  A 602 (-2.7A)
 1.07A 2qebB-3anyA:
undetectable		 2qebB-3anyA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		4 ILE A  92
ARG A  88
ASP A 151
GLU A 146
 None
 1.01A 2qebB-3b9yA:
undetectable		 2qebB-3b9yA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ILE A 118
ARG A 230
TYR A 119
ASP A 227
 None
None
None
NA  A   4 (-2.8A)
 1.00A 2qebB-3bgaA:
undetectable		 2qebB-3bgaA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6l TCR 2W20 ALPHA CHAIN
TCR 2W20 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF09291
(DUF1968) 		4 ILE A 174
ARG B 185
PHE A 139
ASP A 138
 None
 1.11A 2qebB-3c6lA:
undetectable		 2qebB-3c6lA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ILE A  94
ARG A 206
TYR A  95
ASP A 203
 None
 1.01A 2qebB-3decA:
undetectable		 2qebB-3decA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA

(Candida
albicans) 		PF01239
(PPTA) 		4 ILE A 132
ARG A 128
PHE A 124
ASP A 125
 None
None
None
B3P  A 307 (-3.0A)
 1.02A 2qebB-3draA:
undetectable		 2qebB-3draA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzt D7 PROTEIN

(Aedes aegypti) 		PF01395
(PBP_GOBP) 		5 ILE A 175
TYR A 178
TYR A 248
PHE A 264
ASP A 265
 None
TRS  A 306 (-3.8A)
GOL  A 307 (-4.3A)
GOL  A 307 (-4.6A)
TRS  A 306 (-3.6A)
 0.69A 2qebB-3dztA:
14.9		 2qebB-3dztA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		4 ILE A 141
ARG A  86
ASP A 367
GLU A 145
 None
 1.13A 2qebB-3epmA:
undetectable		 2qebB-3epmA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE

(Staphylococcus
haemolyticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 315
ARG A  50
TYR A 316
GLU A 323
 None
 1.11A 2qebB-3fbgA:
undetectable		 2qebB-3fbgA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3b VARIABLE LYMPHOCYTE
RECEPTOR VLRB.2D

(Petromyzon
marinus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ILE A 127
TYR A 122
PHE A  97
ASP A  98
 None
 1.10A 2qebB-3g3bA:
undetectable		 2qebB-3g3bA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		4 ILE A 494
TYR A 490
ASP A 403
GLU A 334
 None
 0.98A 2qebB-3hjbA:
undetectable		 2qebB-3hjbA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ILE A 230
TYR A  91
PHE A 187
ASP A 256
 None
 1.01A 2qebB-3k6kA:
undetectable		 2qebB-3k6kA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		4 ILE A 204
TYR A 199
PHE A 174
ASP A 175
 None
 1.10A 2qebB-3m19A:
undetectable		 2qebB-3m19A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE

(Amycolatopsis
balhimycina) 		PF00067
(p450) 		4 ILE A 120
ARG A 117
ASP A 162
GLU A 161
 None
 1.15A 2qebB-3mgxA:
undetectable		 2qebB-3mgxA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		4 ILE A 493
TYR A 489
ASP A 402
GLU A 333
 None
 1.03A 2qebB-3nbuA:
undetectable		 2qebB-3nbuA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Entamoeba
histolytica) 		PF01791
(DeoC) 		4 ILE A  10
ARG A 204
ASP A  92
GLU A  90
 None
None
ZN  A 251 (-3.2A)
None
 0.99A 2qebB-3ngjA:
undetectable		 2qebB-3ngjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhi D7 PROTEIN

(Anopheles
stephensi) 		PF01395
(PBP_GOBP) 		4 TYR A 179
TYR A 243
ASP A 260
GLU A 263
 SO4  A 299 (-4.9A)
None
None
None
 0.40A 2qebB-3nhiA:
12.1		 2qebB-3nhiA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhi D7 PROTEIN

(Anopheles
stephensi) 		PF01395
(PBP_GOBP) 		4 TYR A 179
TYR A 243
PHE A 259
ASP A 260
 SO4  A 299 (-4.9A)
None
None
None
 0.64A 2qebB-3nhiA:
12.1		 2qebB-3nhiA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntl ACID
GLUCOSE-1-PHOSPHATE
PHOSPHATASE

(Enterobacter
cloacae) 		PF00328
(His_Phos_2) 		4 ILE A 291
ARG A  15
TYR A 303
GLU A 310
 None
IHP  A 550 (-3.9A)
None
None
 1.03A 2qebB-3ntlA:
undetectable		 2qebB-3ntlA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa3 ALDOLASE

(Coccidioides
immitis) 		PF01791
(DeoC) 		4 ILE A  41
ARG A 238
ASP A 123
GLU A 121
 None
 1.01A 2qebB-3oa3A:
undetectable		 2qebB-3oa3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 ILE A 366
PHE A 168
ASP A 167
GLU A 166
 None
None
CA  A 457 ( 2.3A)
None
 1.08A 2qebB-3oqqA:
undetectable		 2qebB-3oqqA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN

(Parabacteroides
distasonis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 414
PHE A 440
ASP A 323
GLU A 320
 None
None
None
ACT  A 609 (-4.3A)
 1.11A 2qebB-3otnA:
undetectable		 2qebB-3otnA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		4 ILE A 322
ARG A 323
TYR A 377
GLU A  15
 None
 1.16A 2qebB-3qwtA:
undetectable		 2qebB-3qwtA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5e TRANSALDOLASE

(Corynebacterium
glutamicum) 		PF00923
(TAL_FSA) 		4 ILE A  62
TYR A  58
PHE A  48
ASP A  83
 None
 1.07A 2qebB-3r5eA:
undetectable		 2qebB-3r5eA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb5 METHIONINE
AMINOPEPTIDASE

(Enterococcus
faecalis) 		PF00557
(Peptidase_M24) 		4 ARG A  81
TYR A  63
ASP A 214
GLU A  74
 None
 1.05A 2qebB-3tb5A:
undetectable		 2qebB-3tb5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ILE A  78
PHE A 519
ASP A 523
GLU A 529
 None
 1.04A 2qebB-3to3A:
undetectable		 2qebB-3to3A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ILE A 240
ARG A 241
TYR A 244
GLU A 275
 None
 1.04A 2qebB-3wfoA:
undetectable		 2qebB-3wfoA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(Aquifex
aeolicus;
synthetic
construct) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		4 ILE A 240
ARG A 241
TYR A 244
GLU A 275
 None
 1.06A 2qebB-3wfpA:
undetectable		 2qebB-3wfpA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo9 VARIABLE LYMPHOCYTE
RECEPTOR C

(Lethenteron
camtschaticum) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ILE A 212
TYR A 207
PHE A 182
ASP A 183
 None
 1.11A 2qebB-3wo9A:
undetectable		 2qebB-3wo9A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		4 ILE A 494
ARG A 493
PHE A 467
GLU A 366
 None
 1.13A 2qebB-3wrfA:
undetectable		 2qebB-3wrfA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		4 ILE A 130
TYR A  89
PHE A 763
ASP A 767
 None
 1.15A 2qebB-4anjA:
undetectable		 2qebB-4anjA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		4 ILE A 175
TYR A 179
TYR A 184
ASP A 206
 NAG  A 503 ( 4.0A)
None
None
None
 1.11A 2qebB-4d3yA:
undetectable		 2qebB-4d3yA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g09 HISTIDINOL
DEHYDROGENASE

(Brucella suis) 		PF00815
(Histidinol_dh) 		4 ILE A 324
ARG A 323
PHE A  12
GLU A  13
 None
 1.16A 2qebB-4g09A:
undetectable		 2qebB-4g09A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN
ERYTHROCYTE BINDING
ANTIGEN 175

(Mus musculus;
Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF07654
(C1-set)
PF07686
(V-set) 		4 ARG L  53
TYR L  32
PHE H 100
GLU A 149
 None
 1.12A 2qebB-4k2uL:
undetectable		 2qebB-4k2uL:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k48 LEUCINE--TRNA LIGASE

(Streptococcus
pneumoniae) 		PF13603
(tRNA-synt_1_2) 		4 ILE A 324
TYR A 327
PHE A 350
ASP A 347
 None
 1.05A 2qebB-4k48A:
undetectable		 2qebB-4k48A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw6 PEROXIREDOXIN-1

(Ancylostoma
ceylanicum) 		PF00578
(AhpC-TSA) 		4 ILE A 130
TYR A  35
PHE A 160
ASP A 164
 None
 1.06A 2qebB-4kw6A:
undetectable		 2qebB-4kw6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le7 PYOCIN L1

(Pseudomonas
aeruginosa) 		PF01453
(B_lectin) 		4 ILE A 248
TYR A  91
PHE A 103
ASP A 105
 None
EDO  A 303 (-4.7A)
None
None
 1.08A 2qebB-4le7A:
undetectable		 2qebB-4le7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 ILE A 261
PHE A 115
ASP A 116
GLU A 119
 None
 1.07A 2qebB-4lxlA:
undetectable		 2qebB-4lxlA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B

(Homo sapiens;
Mus musculus) 		PF00027
(cNMP_binding)
PF00071
(Ras)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 ILE R  36
ARG E 892
TYR R  40
TYR R  32
 None
 1.00A 2qebB-4mh0R:
undetectable		 2qebB-4mh0R:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7y METHIONINE
GAMMA-LYASE

(Citrobacter
freundii) 		PF01053
(Cys_Met_Meta_PP) 		4 ARG A 234
TYR A  56
ASP A  67
GLU A  70
 None
 1.09A 2qebB-4p7yA:
undetectable		 2qebB-4p7yA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po4 LAMPETRA PLANERI
VLRC

(Lampetra
planeri) 		PF13855
(LRR_8) 		4 ILE A 186
TYR A 181
PHE A 156
ASP A 157
 None
 1.07A 2qebB-4po4A:
undetectable		 2qebB-4po4A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 735
ARG A 738
PHE A 709
GLU A 707
 None
 0.78A 2qebB-4ptfA:
undetectable		 2qebB-4ptfA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		4 ILE A 173
ARG A 155
ASP A 376
GLU A 177
 None
 1.16A 2qebB-4s28A:
undetectable		 2qebB-4s28A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqv ALGM2

(Sphingomonas
sp.) 		PF00528
(BPD_transp_1) 		4 ILE B 236
TYR B 231
PHE B  73
ASP B  70
 None
 0.92A 2qebB-4tqvB:
undetectable		 2qebB-4tqvB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		4 ILE A 426
ARG A 427
TYR A 375
ASP A 483
 None
 1.12A 2qebB-4uf7A:
undetectable		 2qebB-4uf7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uip REPEBODY (RAC1)

(Eptatretus
burgeri;
Listeria
monocytogenes;
synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 ILE B 208
TYR B 203
PHE B 178
ASP B 179
 None
 1.15A 2qebB-4uipB:
undetectable		 2qebB-4uipB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Lactobacillus
brevis) 		PF01791
(DeoC) 		4 ILE A  12
ARG A 208
ASP A  94
GLU A  92
 None
 1.00A 2qebB-4xbkA:
undetectable		 2qebB-4xbkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 ILE A 488
TYR A 490
PHE A 343
ASP A 344
 None
None
None
GOL  A 803 ( 4.3A)
 0.89A 2qebB-4yw5A:
undetectable		 2qebB-4yw5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 271
TYR A 272
PHE A 324
ASP A 325
 None
 1.03A 2qebB-4zktA:
undetectable		 2qebB-4zktA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		4 ILE A 465
ARG A 468
TYR A 457
ASP A 422
 None
 1.03A 2qebB-4zu9A:
undetectable		 2qebB-4zu9A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		4 ILE A 151
TYR A 199
PHE A 236
ASP A 233
 None
 1.14A 2qebB-5czwA:
undetectable		 2qebB-5czwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus) 		PF00604
(Flu_PB2) 		4 ILE C 572
TYR C 568
TYR C 685
PHE C 674
 None
 1.15A 2qebB-5d9aC:
undetectable		 2qebB-5d9aC:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 REPEBODY

(Escherichia
coli) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 ILE B 231
TYR B 226
PHE B 201
ASP B 202
 None
 1.13A 2qebB-5gs2B:
undetectable		 2qebB-5gs2B:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig9 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 4 ARG A  74
TYR A 277
PHE A 301
GLU A 300
 None
 1.11A 2qebB-5ig9A:
undetectable		 2qebB-5ig9A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ILE B 609
ARG B 604
ASP B 694
GLU B 697
 None
 1.13A 2qebB-5ip9B:
undetectable		 2qebB-5ip9B:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iu9 PROTOCADHERIN-19
ISOFORM 1

(Danio rerio) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 ILE A 275
TYR A 220
PHE A 215
ASP A 216
 None
 1.08A 2qebB-5iu9A:
undetectable		 2qebB-5iu9A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1q CARBOXYPEPTIDASE B

(Sus scrofa) 		PF00246
(Peptidase_M14) 		4 ILE A 183
ARG A 184
PHE A 147
GLU A 171
 None
 1.13A 2qebB-5j1qA:
undetectable		 2qebB-5j1qA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1x HMPV F1 SUBUNIT
HMPV F2 SUBUNIT

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 ILE B 217
TYR B 269
PHE A  48
GLU B 226
 None
 1.16A 2qebB-5l1xB:
undetectable		 2qebB-5l1xB:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mji BRAMP DOMAIN PROTEIN

(Streptomyces
davaonensis) 		PF03358
(FMN_red) 		4 ILE A  79
ARG A  80
TYR A 154
GLU A 112
 None
 1.14A 2qebB-5mjiA:
undetectable		 2qebB-5mjiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 ILE A  53
ARG A 111
TYR A 193
ASP A 311
 FAD  A 501 (-3.9A)
FAD  A 501 (-2.8A)
8R5  A 502 (-3.9A)
FAD  A 501 (-2.8A)
 1.14A 2qebB-5nagA:
undetectable		 2qebB-5nagA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		4 ILE A 248
ARG A 247
PHE A 194
GLU A 197
 None
 1.12A 2qebB-5nckA:
undetectable		 2qebB-5nckA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A2197
ARG A2196
TYR A2233
GLU A2219
 None
 1.15A 2qebB-5nnnA:
undetectable		 2qebB-5nnnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B

(Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG) 		4 ILE B  74
TYR B   3
ASP B 129
GLU B 124
 None
 1.16A 2qebB-5odrB:
undetectable		 2qebB-5odrB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		4 ILE A 231
TYR A 229
PHE A 300
ASP A 312
 None
 1.12A 2qebB-5thwA:
undetectable		 2qebB-5thwA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u56 MACROPHAGE GROWTH
LOCUS A
STRINGENT STARVATION
PROTEIN A

(Francisella
tularensis) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A  94
ARG A  93
TYR C  59
GLU C  73
 None
 0.97A 2qebB-5u56A:
undetectable		 2qebB-5u56A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz8 CADHERIN-23

(Mus musculus) 		no annotation 4 ILE A2434
TYR A2384
PHE A2379
ASP A2380
 None
 0.78A 2qebB-5uz8A:
undetectable		 2qebB-5uz8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 4 ILE A 413
ARG A 412
PHE A 326
GLU A 425
 None
 0.90A 2qebB-5vaeA:
undetectable		 2qebB-5vaeA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbk PUTATIVE CYTOKININ
RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A  65
ARG A  92
TYR A  40
GLU A  74
 None
AMP  A 304 (-3.9A)
None
AMP  A 304 (-2.5A)
 1.09A 2qebB-5zbkA:
undetectable		 2qebB-5zbkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap4 DNA POLYMERASE III
SUBUNIT BETA

(Acinetobacter
baumannii) 		no annotation 4 ILE A 264
ARG A 261
ASP A 167
GLU A 165
 None
 1.14A 2qebB-6ap4A:
undetectable		 2qebB-6ap4A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Sus scrofa) 		no annotation 4 ILE B 597
ARG B 591
ASP B 666
GLU B 669
 None
 1.16A 2qebB-6exvB:
undetectable		 2qebB-6exvB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 ILE A 394
TYR A 396
TYR A 431
ASP A 462
 None
 1.10A 2qebB-6f91A:
undetectable		 2qebB-6f91A:
16.78