SIMILAR PATTERNS OF AMINO ACIDS FOR 2QE6_B_SAMB400_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gy8 | UDP-GALACTOSE4-EPIMERASE (Trypanosomabrucei) |
PF01370(Epimerase) | 5 | GLY A 8ASP A 75VAL A 76ARG A 77VAL A 96 | NoneNAD A1382 (-2.9A)NAD A1382 (-3.7A)NAD A1382 ( 4.5A)None | 0.85A | 2qe6B-1gy8A:undetectable | 2qe6B-1gy8A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h0h | FORMATEDEHYDROGENASESUBUNIT ALPHA (Desulfovibriogigas) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 5 | ILE A 737TYR A 170GLY A 397VAL A 756GLY A 402 | None | 1.02A | 2qe6B-1h0hA:3.3 | 2qe6B-1h0hA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h2b | ALCOHOLDEHYDROGENASE (Aeropyrumpernix) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 48ALA A 138GLY A 78VAL A 53GLY A 52 | None | 0.97A | 2qe6B-1h2bA:4.1 | 2qe6B-1h2bA:26.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htq | GLUTAMINE SYNTHETASE (Mycobacteriumtuberculosis) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 5 | ILE A 134TYR A 133ASP A 193GLY A 216TYR A 188 | None | 1.09A | 2qe6B-1htqA:undetectable | 2qe6B-1htqA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htq | GLUTAMINE SYNTHETASE (Mycobacteriumtuberculosis) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 5 | ILE A 134TYR A 133GLY A 214GLY A 216TYR A 188 | None | 0.98A | 2qe6B-1htqA:undetectable | 2qe6B-1htqA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ir6 | EXONUCLEASE RECJ (Thermusthermophilus) |
PF01368(DHH)PF02272(DHHA1) | 5 | ILE A 272ALA A 269GLY A 217ASP A 212GLY A 85 | None | 0.86A | 2qe6B-1ir6A:3.0 | 2qe6B-1ir6A:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1llu | ALCOHOLDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 38ALA A 127GLY A 66VAL A 43GLY A 42 | None | 0.96A | 2qe6B-1lluA:5.0 | 2qe6B-1lluA:25.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nkv | HYPOTHETICAL PROTEINYJHP (Escherichiacoli) |
PF13847(Methyltransf_31) | 5 | GLY A 44GLY A 46ASP A 94VAL A 110GLY A 111 | None | 0.33A | 2qe6B-1nkvA:10.2 | 2qe6B-1nkvA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1npm | NEUROPSIN (Mus musculus) |
PF00089(Trypsin) | 5 | ILE A 103ALA A 55GLY A 196VAL A 47GLY A 211 | None | 1.02A | 2qe6B-1npmA:undetectable | 2qe6B-1npmA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1n | HYPOTHETICALZINC-TYPE ALCOHOLDEHYDROGENASE-LIKEPROTEIN IN PRE5-FET4INTERGENIC REGION (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 136GLY A 134VAL A 141VAL A 71GLY A 72 | None | 0.97A | 2qe6B-1q1nA:4.0 | 2qe6B-1q1nA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ri3 | MRNA CAPPING ENZYME (Encephalitozooncuniculi) |
PF03291(Pox_MCEL) | 5 | GLY A 72GLY A 74ILE A 95ASP A 122TYR A 145 | SAH A 299 (-3.3A)SAH A 299 (-3.5A)SAH A 299 (-3.8A)SAH A 299 (-3.2A)SAH A 299 (-4.2A) | 0.47A | 2qe6B-1ri3A:13.8 | 2qe6B-1ri3A:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbf | 231AA LONGHYPOTHETICALPROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF01135(PCMT) | 5 | ILE A 196GLY A 78ILE A 100VAL A 98VAL A 139 | None | 1.03A | 2qe6B-1vbfA:5.7 | 2qe6B-1vbfA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w27 | PHENYLALANINEAMMONIA-LYASE 1 (Petroselinumcrispum) |
PF00221(Lyase_aromatic) | 5 | ILE A 523ALA A 522GLY A 518ILE A 289TYR A 661 | None | 0.84A | 2qe6B-1w27A:undetectable | 2qe6B-1w27A:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjy | R-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacillusbrevis) |
PF13561(adh_short_C2) | 5 | ILE A 22ALA A 21GLY A 17ILE A 222GLY A 13 | NoneNoneNAI A1270 (-3.9A)NoneNAI A1270 (-2.9A) | 0.78A | 2qe6B-1zjyA:6.5 | 2qe6B-1zjyA:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bd0 | SEPIAPTERINREDUCTASE (Chlorobaculumtepidum) |
PF00106(adh_short) | 5 | ILE A 18ALA A 17GLY A 13ILE A 213GLY A 9 | NoneNoneNAP A 800 (-3.5A)NoneNAP A 800 (-3.2A) | 0.99A | 2qe6B-2bd0A:6.5 | 2qe6B-2bd0A:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cn3 | BETA-1,4-XYLOGLUCANHYDROLASE (Ruminiclostridiumthermocellum) |
PF02012(BNR) | 5 | ALA A 331GLY A 332ARG A 163VAL A 277GLY A 276 | None | 1.02A | 2qe6B-2cn3A:undetectable | 2qe6B-2cn3A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nm0 | PROBABLE3-OXACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Streptomycescoelicolor) |
PF13561(adh_short_C2) | 5 | ILE A 18ALA A 17GLY A 13ILE A 204GLY A 9 | None | 0.93A | 2qe6B-2nm0A:undetectable | 2qe6B-2nm0A:26.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p8j | S-ADENOSYLMETHIONINE-DEPENDENTMETHYLTRANSFERASE (Clostridiumacetobutylicum) |
PF08241(Methyltransf_11) | 5 | GLY A 30GLY A 32ILE A 53ASP A 78ARG A 80 | GOL A 213 ( 3.7A)NoneGOL A 213 (-4.0A)NoneNone | 0.81A | 2qe6B-2p8jA:14.4 | 2qe6B-2p8jA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p8j | S-ADENOSYLMETHIONINE-DEPENDENTMETHYLTRANSFERASE (Clostridiumacetobutylicum) |
PF08241(Methyltransf_11) | 5 | GLY A 30ILE A 53ASP A 78ARG A 80GLY A 96 | GOL A 213 ( 3.7A)GOL A 213 (-4.0A)NoneNoneNone | 0.57A | 2qe6B-2p8jA:14.4 | 2qe6B-2p8jA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pxx | UNCHARACTERIZEDPROTEIN MGC2408 (Homo sapiens) |
PF08241(Methyltransf_11) | 5 | GLY A 66GLY A 68ASP A 113VAL A 114GLY A 131 | SAH A 301 (-3.8A)SAH A 301 ( 3.2A)SAH A 301 (-3.1A)SAH A 301 (-3.6A)SAH A 301 (-4.1A) | 0.37A | 2qe6B-2pxxA:11.0 | 2qe6B-2pxxA:25.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qe6 | UNCHARACTERIZEDPROTEIN TFU_2867 (Thermobifidafusca) |
PF04672(Methyltransf_19) | 12 | ILE A 22ALA A 23TYR A 26GLY A 84GLY A 86ILE A 111ASP A 135VAL A 136ARG A 137VAL A 163GLY A 164TYR A 168 | SAM A 400 ( 3.7A)SAM A 400 (-3.1A)SAM A 400 ( 3.8A)SAM A 400 (-3.4A)SAM A 400 ( 3.2A)SAM A 400 (-3.7A)SAM A 400 (-3.4A)SAM A 400 (-3.8A)SAM A 400 (-4.6A)SAM A 400 (-4.2A)SAM A 400 (-3.5A)SAM A 400 ( 4.5A) | 0.11A | 2qe6B-2qe6A:49.4 | 2qe6B-2qe6A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uvd | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 5 | ILE A 20ALA A 19GLY A 15ILE A 218GLY A 11 | None | 0.83A | 2qe6B-2uvdA:5.7 | 2qe6B-2uvdA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z3b | ATP-DEPENDENTPROTEASE HSLV (Bacillussubtilis) |
PF00227(Proteasome) | 5 | ALA A 135TYR A 134GLY A 132ILE A 125ASP A 123 | None | 1.06A | 2qe6B-2z3bA:undetectable | 2qe6B-2z3bA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dla | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Mycobacteriumtuberculosis) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 5 | GLY A 234GLY A 236ARG A 262VAL A 267GLY A 266 | None | 0.98A | 2qe6B-3dlaA:2.3 | 2qe6B-3dlaA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emk | GLUCOSE/RIBITOLDEHYDROGENASE (Brucellamelitensis) |
PF13561(adh_short_C2) | 5 | ILE A 22ALA A 21GLY A 17ILE A 216GLY A 13 | None | 0.92A | 2qe6B-3emkA:6.1 | 2qe6B-3emkA:25.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ftp | 3-OXOACYL-[ACYL-CARRIER PROTEIN]REDUCTASE (Burkholderiapseudomallei) |
PF13561(adh_short_C2) | 5 | ILE A 23ALA A 22GLY A 18ILE A 220GLY A 14 | None | 0.88A | 2qe6B-3ftpA:5.9 | 2qe6B-3ftpA:25.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7u | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Escherichiacoli) |
PF00145(DNA_methylase) | 5 | GLY A 9ILE A 30ASP A 51VAL A 52GLY A 76 | None | 0.87A | 2qe6B-3g7uA:6.6 | 2qe6B-3g7uA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gaf | 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Brucellaabortus) |
PF13561(adh_short_C2) | 5 | ILE A 27ALA A 26GLY A 22ILE A 224GLY A 18 | None | 0.84A | 2qe6B-3gafA:6.3 | 2qe6B-3gafA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gce | FERREDOXIN COMPONENTOF CARBAZOLE1,9A-DIOXYGENASE (Nocardioidesaromaticivorans) |
PF00355(Rieske) | 5 | ASP A 80VAL A 81ARG A 82VAL A 24GLY A 23 | None | 0.81A | 2qe6B-3gceA:undetectable | 2qe6B-3gceA:19.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3go4 | PROTEIN OF UNKNOWNFUNCTION DUF574 (Streptomycesavermitilis) |
PF04672(Methyltransf_19) | 5 | ALA A 24TYR A 27GLY A 85GLY A 87ASP A 138 | SAH A 277 (-3.1A)SAH A 277 (-4.3A)SAH A 277 (-3.4A)SAH A 277 (-3.1A)SAH A 277 (-3.5A) | 0.48A | 2qe6B-3go4A:36.1 | 2qe6B-3go4A:40.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3grp | 3-OXOACYL-(ACYLCARRIERPROTEIN)REDUCTASE (Bartonellahenselae) |
PF13561(adh_short_C2) | 5 | ILE A 22ALA A 21GLY A 17ILE A 216GLY A 13 | None | 0.83A | 2qe6B-3grpA:2.7 | 2qe6B-3grpA:24.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gym | PROSTASIN (Homo sapiens) |
PF00089(Trypsin) | 5 | ILE A 103ALA A 55GLY A 196VAL A 47GLY A 211 | None | 0.99A | 2qe6B-3gymA:undetectable | 2qe6B-3gymA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icc | PUTATIVE3-OXOACYL-(ACYLCARRIER PROTEIN)REDUCTASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 5 | ILE A 20ALA A 19GLY A 15ILE A 224GLY A 11 | ILE A 20 ( 0.7A)ALA A 19 ( 0.0A)GLY A 15 ( 0.0A)ILE A 224 ( 0.7A)GLY A 11 ( 0.0A) | 0.91A | 2qe6B-3iccA:5.4 | 2qe6B-3iccA:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kvo | HYDROXYSTEROIDDEHYDROGENASE-LIKEPROTEIN 2 (Homo sapiens) |
PF00106(adh_short) | 5 | ILE A 26ALA A 25GLY A 21ILE A 224GLY A 17 | NoneNoneNAP A 501 (-3.5A)NoneNAP A 501 (-3.3A) | 0.87A | 2qe6B-3kvoA:6.2 | 2qe6B-3kvoA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lcc | PUTATIVE METHYLCHLORIDE TRANSFERASE (Arabidopsisthaliana) |
PF05724(TPMT) | 5 | GLY A 74GLY A 76ASP A 123VAL A 124VAL A 140 | SAH A 300 (-3.5A)SAH A 300 (-3.5A)SAH A 300 (-3.8A)SAH A 300 (-4.1A)SAH A 300 (-4.2A) | 1.05A | 2qe6B-3lccA:11.9 | 2qe6B-3lccA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3meq | ALCOHOLDEHYDROGENASE,ZINC-CONTAINING (Brucella suis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 36ALA A 125GLY A 64VAL A 41GLY A 40 | None | 0.93A | 2qe6B-3meqA:4.9 | 2qe6B-3meqA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ne8 | N-ACETYLMURAMOYL-L-ALANINE AMIDASE (Bartonellahenselae) |
PF01520(Amidase_3) | 5 | GLY A 189GLY A 193ASP A 297ARG A 237GLY A 187 | None | 0.98A | 2qe6B-3ne8A:undetectable | 2qe6B-3ne8A:24.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o7w | LEUCINE CARBOXYLMETHYLTRANSFERASE 1 (Homo sapiens) |
PF04072(LCM) | 5 | GLY A 98GLY A 100ASP A 171ARG A 173TYR A 203 | SAM A 801 (-3.5A)SAM A 801 ( 3.7A)SAM A 801 (-3.8A)NoneSAM A 801 (-4.6A) | 0.35A | 2qe6B-3o7wA:16.0 | 2qe6B-3o7wA:24.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pgx | CARVEOLDEHYDROGENASE (Mycobacteriumavium) |
PF13561(adh_short_C2) | 5 | ALA A 20ILE A 43ASP A 81VAL A 82VAL A 106 | NAD A 277 ( 3.9A)NAD A 277 (-3.7A)NAD A 277 (-3.5A)NAD A 277 (-3.6A)None | 1.08A | 2qe6B-3pgxA:5.7 | 2qe6B-3pgxA:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pgx | CARVEOLDEHYDROGENASE (Mycobacteriumavium) |
PF13561(adh_short_C2) | 5 | ALA A 56ILE A 43ASP A 81VAL A 82ARG A 83 | NAD A 277 (-3.3A)NAD A 277 (-3.7A)NAD A 277 (-3.5A)NAD A 277 (-3.6A)NAD A 277 ( 4.7A) | 0.82A | 2qe6B-3pgxA:5.7 | 2qe6B-3pgxA:24.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pxx | CARVEOLDEHYDROGENASE (Mycobacteriumavium) |
PF13561(adh_short_C2) | 6 | ALA A 15GLY A 14ILE A 38ASP A 75VAL A 76VAL A 100 | NAD A 284 ( 4.2A)NoneNAD A 284 (-3.6A)NAD A 284 (-3.7A)NAD A 284 (-3.5A)None | 1.39A | 2qe6B-3pxxA:5.7 | 2qe6B-3pxxA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pxx | CARVEOLDEHYDROGENASE (Mycobacteriumavium) |
PF13561(adh_short_C2) | 5 | ALA A 50ILE A 38ASP A 75VAL A 76ARG A 77 | NAD A 284 (-3.4A)NAD A 284 (-3.6A)NAD A 284 (-3.7A)NAD A 284 (-3.5A)None | 0.84A | 2qe6B-3pxxA:5.7 | 2qe6B-3pxxA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pxx | CARVEOLDEHYDROGENASE (Mycobacteriumavium) |
PF13561(adh_short_C2) | 5 | GLY A 14ILE A 38ASP A 75VAL A 76ARG A 77 | NoneNAD A 284 (-3.6A)NAD A 284 (-3.7A)NAD A 284 (-3.5A)None | 0.79A | 2qe6B-3pxxA:5.7 | 2qe6B-3pxxA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q6t | 43.2 KDA SALIVARYPROTEIN (Lutzomyialongipalpis) |
PF03022(MRJP) | 5 | ILE A 222ALA A 242GLY A 243ARG A 180GLY A 155 | None | 1.07A | 2qe6B-3q6tA:undetectable | 2qe6B-3q6tA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rkr | SHORT CHAINOXIDOREDUCTASE (unculturedbacterium Bio5) |
PF00106(adh_short) | 5 | ILE A 22ALA A 21GLY A 17ILE A 212GLY A 13 | NoneNoneSO4 A 242 (-3.6A)NoneNAP A 240 (-3.4A) | 0.86A | 2qe6B-3rkrA:6.2 | 2qe6B-3rkrA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmj | 2-ISOPROPYLMALATESYNTHASE (Neisseriameningitidis) |
PF00682(HMGL-like) | 5 | GLY A 164ASP A 137VAL A 138ARG A 97VAL A 125 | None | 1.09A | 2qe6B-3rmjA:undetectable | 2qe6B-3rmjA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rre | PUTATIVEUNCHARACTERIZEDPROTEIN (Thermotogamaritima) |
PF01256(Carb_kinase)PF03853(YjeF_N) | 5 | ILE A 116ALA A 115GLY A 50GLY A 53GLY A 76 | NoneNoneADP A 494 (-3.3A)NoneNone | 1.02A | 2qe6B-3rreA:3.9 | 2qe6B-3rreA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3szb | ALDEHYDEDEHYDROGENASE (Homo sapiens) |
PF00171(Aldedh) | 5 | ALA A 362GLY A 402GLY A 383ILE A 394GLY A 408 | None | 0.99A | 2qe6B-3szbA:3.6 | 2qe6B-3szbA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tju | GRANZYME H (Homo sapiens) |
PF00089(Trypsin) | 5 | ILE A 104ALA A 57GLY A 198VAL A 49GLY A 209 | None | 1.00A | 2qe6B-3tjuA:undetectable | 2qe6B-3tjuA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u5t | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | ILE A 20ALA A 19GLY A 15ILE A 217GLY A 11 | None | 0.86A | 2qe6B-3u5tA:6.1 | 2qe6B-3u5tA:26.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uve | CARVEOLDEHYDROGENASE((+)-TRANS-CARVEOLDEHYDROGENASE) (Mycobacteriumavium) |
PF13561(adh_short_C2) | 5 | ALA A 16ILE A 39ASP A 80VAL A 81VAL A 105 | NAD A 300 ( 3.8A)NAD A 300 (-3.8A)NAD A 300 (-3.4A)NAD A 300 (-3.6A)None | 1.03A | 2qe6B-3uveA:5.6 | 2qe6B-3uveA:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v2g | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | ILE A 47ALA A 46GLY A 42ILE A 243GLY A 38 | NoneNoneNoneNoneSO4 A 273 ( 4.9A) | 0.96A | 2qe6B-3v2gA:2.4 | 2qe6B-3v2gA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wtb | PUTATIVEOXIDOREDUCTASE (Gluconobacteroxydans) |
PF13561(adh_short_C2) | 5 | ILE A 19ALA A 18GLY A 14ILE A 215GLY A 10 | None | 0.83A | 2qe6B-3wtbA:5.0 | 2qe6B-3wtbA:25.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a11 | DNA EXCISION REPAIRPROTEIN ERCC-8 (Homo sapiens) |
PF00400(WD40) | 5 | ILE B 201ASP B 215VAL B 216ARG B 217VAL B 159 | None | 0.83A | 2qe6B-4a11B:undetectable | 2qe6B-4a11B:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a35 | MITOCHONDRIALENOLASE SUPERFAMILYMEMBER 1 (Homo sapiens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 121GLY A 57ASP A 17VAL A 18ARG A 19 | NoneNoneNoneNoneEDO A1447 (-4.0A) | 0.96A | 2qe6B-4a35A:undetectable | 2qe6B-4a35A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bko | PUTATIVE REDUCTASEBURPS305_1051 (Burkholderiapseudomallei) |
PF07055(Eno-Rase_FAD_bd)PF12241(Enoyl_reductase)PF12242(Eno-Rase_NADH_b) | 5 | ALA A 57ASP A 133VAL A 132VAL A 72GLY A 71 | None | 1.02A | 2qe6B-4bkoA:undetectable | 2qe6B-4bkoA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bo6 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE FABG (Pseudomonasaeruginosa) |
PF13561(adh_short_C2) | 5 | ILE A 21ALA A 20GLY A 16ILE A 218GLY A 12 | None | 0.88A | 2qe6B-4bo6A:6.6 | 2qe6B-4bo6A:26.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dgj | ENTEROPEPTIDASECATALYTIC LIGHTCHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | ILE A 93ALA A 39GLY A 188VAL A 31GLY A 203 | None | 1.06A | 2qe6B-4dgjA:undetectable | 2qe6B-4dgjA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dng | UNCHARACTERIZEDALDEHYDEDEHYDROGENASE ALDY (Bacillussubtilis) |
PF00171(Aldedh) | 5 | TYR A 30GLY A 327ILE A 330VAL A 359GLY A 360 | None | 0.97A | 2qe6B-4dngA:3.3 | 2qe6B-4dngA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fn4 | SHORT CHAINDEHYDROGENASE (Sulfolobusacidocaldarius) |
PF13561(adh_short_C2) | 5 | ILE A 24ALA A 23GLY A 19ILE A 226GLY A 15 | NoneNoneNAD A 501 (-3.3A)NoneNAD A 501 (-3.2A) | 0.97A | 2qe6B-4fn4A:6.4 | 2qe6B-4fn4A:25.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gvx | 3-OXOACYL-[ACYL-CARRIER PROTEIN]REDUCTASE (Burkholderiamultivorans) |
PF13561(adh_short_C2) | 5 | ILE A 23ALA A 22GLY A 18ILE A 224GLY A 14 | NoneNoneNAP A 301 (-3.5A)NoneNAP A 301 (-3.2A) | 0.93A | 2qe6B-4gvxA:5.9 | 2qe6B-4gvxA:24.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hp8 | 2-DEOXY-D-GLUCONATE3-DEHYDROGENASE (Agrobacteriumfabrum) |
PF13561(adh_short_C2) | 5 | ILE A 218GLY A 20ILE A 137VAL A 84VAL A 27 | NoneNAP A 301 (-3.3A)NAP A 301 (-4.5A)NoneNone | 1.01A | 2qe6B-4hp8A:4.9 | 2qe6B-4hp8A:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hp8 | 2-DEOXY-D-GLUCONATE3-DEHYDROGENASE (Agrobacteriumfabrum) |
PF13561(adh_short_C2) | 5 | ILE A 218GLY A 22GLY A 20ILE A 137VAL A 27 | NoneNoneNAP A 301 (-3.3A)NAP A 301 (-4.5A)None | 1.07A | 2qe6B-4hp8A:4.9 | 2qe6B-4hp8A:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvt | POST-PROLINECLEAVING ENZYME (Rickettsiatyphi) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 5 | ILE A 516ALA A 538GLY A 487VAL A 490GLY A 568 | None | 1.03A | 2qe6B-4hvtA:undetectable | 2qe6B-4hvtA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i59 | CYCLOHEXYLAMINEOXIDASE (Microbacteriumoxydans) |
PF01593(Amino_oxidase) | 5 | GLY A 43GLY A 40VAL A 288VAL A 464GLY A 463 | NoneFAD A 501 (-3.5A)NoneNoneFAD A 501 ( 4.5A) | 0.74A | 2qe6B-4i59A:undetectable | 2qe6B-4i59A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4itu | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Xanthobacterautotrophicus) |
PF13561(adh_short_C2) | 5 | ILE A 23ALA A 22GLY A 18ILE A 226GLY A 14 | NoneNoneNAI A 301 (-3.5A)NoneNAI A 301 (-3.3A) | 0.88A | 2qe6B-4ituA:6.5 | 2qe6B-4ituA:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m3c | LECTIN BETA CHAIN (Buteamonosperma) |
PF00139(Lectin_legB) | 5 | ALA B 105GLY B 109GLY B 104ASP B 146GLY B 49 | None | 0.96A | 2qe6B-4m3cB:undetectable | 2qe6B-4m3cB:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m73 | METHYLTRANSFERASEMPPJ (Streptomyceshygroscopicus) |
PF13649(Methyltransf_25) | 5 | GLY A 166GLY A 168ILE A 190ASP A 217ARG A 219 | SAH A 401 (-3.4A)SAH A 401 (-3.5A)SAH A 401 (-3.8A)SAH A 401 ( 3.7A)SAH A 401 (-4.5A) | 0.37A | 2qe6B-4m73A:15.1 | 2qe6B-4m73A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m8s | PUTATIVE3-OXOACYL-[ACYL-CARRIER PROTEIN]REDUCTASE (Neisseriameningitidis) |
PF13561(adh_short_C2) | 5 | ILE A 24ALA A 23GLY A 19ILE A 219GLY A 15 | None | 0.84A | 2qe6B-4m8sA:6.0 | 2qe6B-4m8sA:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mlc | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Desulfitobacteriumhafniense) |
PF13458(Peripla_BP_6) | 5 | ILE A 62ALA A 63GLY A 77ILE A 83GLY A 11 | None | 0.96A | 2qe6B-4mlcA:undetectable | 2qe6B-4mlcA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mow | GLUCOSE1-DEHYDROGENASE (Burkholderiacenocepacia) |
PF13561(adh_short_C2) | 5 | ILE A 22ALA A 21GLY A 17ILE A 221GLY A 13 | None | 0.86A | 2qe6B-4mowA:6.0 | 2qe6B-4mowA:25.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n1a | CELLDIVISIONFTSK/SPOIIIE (Thermomonosporacurvata) |
PF01580(FtsK_SpoIIIE) | 5 | ILE A1260ALA A1254TYR A1256GLY A1252VAL A1272 | None | 0.86A | 2qe6B-4n1aA:undetectable | 2qe6B-4n1aA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n54 | INOSITOLDEHYDROGENASE (Lactobacilluscasei) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | ALA A 35GLY A 9ASP A 61VAL A 75GLY A 12 | NoneNoneNoneNAI A 401 (-4.6A)NAI A 401 (-3.5A) | 1.04A | 2qe6B-4n54A:3.4 | 2qe6B-4n54A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nbt | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Acholeplasmalaidlawii) |
PF13561(adh_short_C2) | 5 | ILE A 22ALA A 21GLY A 17ILE A 212GLY A 13 | NoneNoneNAD A 301 (-3.4A)NoneNAD A 301 (-3.0A) | 0.89A | 2qe6B-4nbtA:5.9 | 2qe6B-4nbtA:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qrk | HYPOTHETICAL PROTEIN (Clostridiumsporogenes) |
PF09922(DUF2154)PF17115(Toast_rack_N) | 5 | GLY A 180GLY A 156ILE A 235VAL A 159GLY A 160 | None | 0.88A | 2qe6B-4qrkA:undetectable | 2qe6B-4qrkA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf3 | NADPH DEPENDENTR-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacilluskefiri) |
PF13561(adh_short_C2) | 5 | ILE A 23ALA A 22GLY A 18ILE A 223GLY A 14 | None | 0.84A | 2qe6B-4rf3A:6.3 | 2qe6B-4rf3A:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rmx | PHI92_GP150 (Enterobacteriaphage phi92) |
no annotation | 5 | ILE A 384TYR A 360GLY A 424GLY A 422VAL A 453 | None | 0.96A | 2qe6B-4rmxA:undetectable | 2qe6B-4rmxA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvi | AMINOTRANSFERASE,CLASS IV (Brucellaabortus) |
PF01063(Aminotran_4) | 5 | GLY A 269ILE A 233ASP A 69ARG A 237VAL A 275 | LLP A 172 ( 3.5A)LLP A 172 ( 4.1A)NoneNoneNone | 1.06A | 2qe6B-4tviA:undetectable | 2qe6B-4tviA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u7t | DNA(CYTOSINE-5)-METHYLTRANSFERASE 3A (Homo sapiens) |
PF00145(DNA_methylase) | 5 | GLY A 642ASP A 686VAL A 687ARG A 688GLY A 707 | SAH A1004 (-3.3A)SAH A1004 (-3.0A)SAH A1004 (-3.7A)SAH A1004 (-4.4A)None | 0.69A | 2qe6B-4u7tA:5.5 | 2qe6B-4u7tA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wec | SHORT CHAINDEHYDROGENASE (Mycolicibacteriumsmegmatis) |
PF13561(adh_short_C2) | 5 | ALA A 18GLY A 17ILE A 41ASP A 61VAL A 62 | NAD A 301 (-3.4A)NAD A 301 ( 4.8A)NAD A 301 (-3.8A)NAD A 301 (-3.9A)NAD A 301 (-3.5A) | 1.07A | 2qe6B-4wecA:5.8 | 2qe6B-4wecA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp7 | SAM-DEPENDENTMETHYLTRANSFERASE (Geobactersulfurreducens) |
PF13847(Methyltransf_31) | 5 | GLY A 45GLY A 47ASP A 95VAL A 111GLY A 112 | SAH A 301 (-3.6A)SAH A 301 (-3.5A)SAH A 301 (-3.3A)SAH A 301 (-4.1A)SAH A 301 ( 4.7A) | 0.45A | 2qe6B-5bp7A:10.0 | 2qe6B-5bp7A:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2c | FORM II RUBISCO (Gallionella) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ALA A 392ILE A 164ASP A 193VAL A 322GLY A 323 | NoneKCX A 191 ( 4.1A) MG A 501 (-2.9A)NoneNone | 0.92A | 2qe6B-5c2cA:undetectable | 2qe6B-5c2cA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cej | 3-OXOACYL-[ACYL-CARRIER PROTEIN]REDUCTASE (Yersinia pestis) |
PF13561(adh_short_C2) | 5 | ILE A 21ALA A 20GLY A 16ILE A 215GLY A 12 | None | 0.81A | 2qe6B-5cejA:5.9 | 2qe6B-5cejA:26.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ck7 | ADP-DEPENDENTGLUCOKINASE (Mus musculus) |
PF04587(ADP_PFK_GK) | 5 | ILE A 163ALA A 160GLY A 158VAL A 476GLY A 477 | None | 1.09A | 2qe6B-5ck7A:4.1 | 2qe6B-5ck7A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9j | MRNA CAP GUANINE-N7METHYLTRANSFERASE,MRNA CAP GUANINE-N7METHYLTRANSFERASE (Homo sapiens) |
PF03291(Pox_MCEL) | 5 | GLY A 205GLY A 207ILE A 228ASP A 261TYR A 289 | SAH A 501 (-3.4A)SAH A 501 (-3.4A)SAH A 501 (-3.8A)SAH A 501 (-3.5A)SAH A 501 (-4.0A) | 0.62A | 2qe6B-5e9jA:15.2 | 2qe6B-5e9jA:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9w | MRNA CAP GUANINE-N7METHYLTRANSFERASE (Homo sapiens) |
PF03291(Pox_MCEL) | 5 | GLY A 205GLY A 207ILE A 228ASP A 261TYR A 289 | SAH A 500 (-3.8A)SAH A 500 (-3.5A)SAH A 500 (-3.7A)SAH A 500 (-3.6A)SAH A 500 (-4.0A) | 0.64A | 2qe6B-5e9wA:15.4 | 2qe6B-5e9wA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ej2 | CARVEOLDEHYDROGENASE (Mycobacteriumavium) |
PF13561(adh_short_C2) | 5 | ALA A 24ILE A 47ASP A 84VAL A 85VAL A 109 | NAD A 300 ( 3.8A)NAD A 300 (-3.8A)NAD A 300 (-3.3A)NAD A 300 (-3.6A)None | 1.06A | 2qe6B-5ej2A:undetectable | 2qe6B-5ej2A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5end | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE FABG (Vibrio cholerae) |
PF13561(adh_short_C2) | 5 | ILE A 25ALA A 24GLY A 20ILE A 219GLY A 16 | None | 0.78A | 2qe6B-5endA:6.2 | 2qe6B-5endA:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epe | SAM-DEPENDENTMETHYLTRANSFERASE (Thiobacillusdenitrificans) |
PF13847(Methyltransf_31) | 5 | GLY A 44GLY A 46ASP A 94VAL A 110GLY A 111 | SAH A 301 (-3.6A)SAH A 301 (-3.4A)SAH A 301 (-3.5A)SAH A 301 (-4.2A)SAH A 301 (-4.9A) | 0.52A | 2qe6B-5epeA:8.8 | 2qe6B-5epeA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5je3 | METHYL TRANSFERASE (Burkholderiaglumae) |
PF13847(Methyltransf_31) | 5 | GLY A 49ILE A 70ASP A 95VAL A 96TYR A 116 | SAH A 301 (-3.6A)SAH A 301 (-3.7A)SAH A 301 (-3.7A)SAH A 301 (-3.9A)SAH A 301 (-4.0A) | 0.53A | 2qe6B-5je3A:12.9 | 2qe6B-5je3A:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1r | BURKHOLDERIAPSEUDOMALLEISPHINGOSINE-1-PHOSPHATE LYASE BPSS2021 (Burkholderiapseudomallei) |
PF00282(Pyridoxal_deC) | 6 | ILE A 222ALA A 221GLY A 217ASP A 186VAL A 185VAL A 232 | None | 1.20A | 2qe6B-5k1rA:undetectable | 2qe6B-5k1rA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kpg | PAVINEN-METHYLTRANSFERASE (Thalictrumflavum) |
PF02353(CMAS) | 5 | GLY A 135GLY A 137ASP A 185VAL A 186VAL A 201 | SAH A 401 (-3.7A)SAH A 401 ( 3.8A)SAH A 401 (-3.5A)SAH A 401 (-3.8A)SAH A 401 (-4.3A) | 0.48A | 2qe6B-5kpgA:10.6 | 2qe6B-5kpgA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5unl | 3-KETOACYL-ACPREDUCTASE (Burkholderiamultivorans) |
PF13561(adh_short_C2) | 5 | ILE A 28ALA A 27GLY A 23ILE A 236GLY A 19 | None | 0.90A | 2qe6B-5unlA:6.5 | 2qe6B-5unlA:25.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 61GLY A 63ASP A 107VAL A 108TYR A 131 | SAH A 701 (-3.4A)SAH A 701 (-3.5A)SAH A 701 (-3.2A)SAH A 701 (-3.6A)None | 0.58A | 2qe6B-5wp4A:13.9 | 2qe6B-5wp4A:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp5 | PHOSPHOMETHYLETHANOLAMINEN-METHYLTRANSFERASE2 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 61GLY A 63ASP A 107VAL A 108TYR A 131 | SAH A 502 (-3.4A)SAH A 502 (-3.5A)SAH A 502 (-3.2A)SAH A 502 (-3.6A)SAH A 502 ( 4.8A) | 0.55A | 2qe6B-5wp5A:13.3 | 2qe6B-5wp5A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wva | SHORT-CHAINDEHYDROGENASE (Serratiamarcescens) |
no annotation | 5 | ILE A 25ALA A 24GLY A 20ILE A 221GLY A 16 | None | 0.86A | 2qe6B-5wvaA:6.4 | 2qe6B-5wvaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bqc | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE (Escherichiacoli) |
no annotation | 5 | GLY A 175GLY A 177ASP A 221VAL A 235GLY A 236 | NoneNoneNoneNoneLOP A 402 ( 3.4A) | 0.64A | 2qe6B-6bqcA:11.8 | 2qe6B-6bqcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brr | DNA(CYTOSINE-5)-METHYLTRANSFERASE 3A (Homo sapiens) |
no annotation | 5 | GLY A 642ASP A 686VAL A 687ARG A 688GLY A 707 | SAH A1001 (-3.4A)SAH A1001 (-3.0A)SAH A1001 (-3.7A)NoneSAH A1001 (-4.4A) | 0.78A | 2qe6B-6brrA:5.5 | 2qe6B-6brrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dux | 6-PHOSPHO-ALPHA-GLUCOSIDASE (Klebsiellapneumoniae) |
no annotation | 5 | ALA A 117GLY A 112GLY A 115ILE A 409GLY A 107 | None | 1.04A | 2qe6B-6duxA:2.6 | 2qe6B-6duxA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ehe | OMPT PROTEIN (Vibrio cholerae) |
no annotation | 5 | ALA A 97GLY A 107ILE A 233VAL A 254GLY A 104 | None | 0.94A | 2qe6B-6eheA:undetectable | 2qe6B-6eheA:undetectable |