SIMILAR PATTERNS OF AMINO ACIDS FOR 2QE6_A_SAMA400

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfz HYDROGENASE 2
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		5 ILE A  60
ALA A  61
GLY A   9
GLY A  19
GLY A  41
 None
None
CD  A 163 ( 4.2A)
None
None
 0.87A 2qe6A-1cfzA:
undetectable		 2qe6A-1cfzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)

(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9)
PF02256
(Fe_hyd_SSU) 		5 ALA A 109
GLY A 381
GLY A 297
ILE D  47
GLY A 386
 PDT  A   4 ( 3.1A)
SF4  A   3 ( 3.9A)
PDT  A   4 (-3.3A)
None
SF4  A   3 ( 4.3A)
 0.90A 2qe6A-1e08A:
undetectable		 2qe6A-1e08A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		6 ALA A   9
GLY A   8
ASP A  75
VAL A  76
ARG A  77
VAL A  96
 NAD  A1382 ( 4.3A)
None
NAD  A1382 (-2.9A)
NAD  A1382 (-3.7A)
NAD  A1382 ( 4.5A)
None
 1.40A 2qe6A-1gy8A:
undetectable		 2qe6A-1gy8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10)
PF02256
(Fe_hyd_SSU) 		5 GLY L 297
GLY L 381
VAL L 302
GLY L 301
TYR S  51
 CYN  L 429 ( 3.7A)
SF4  L 424 ( 4.4A)
None
None
None
 0.87A 2qe6A-1hfeL:
undetectable		 2qe6A-1hfeL:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htq GLUTAMINE SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		6 ILE A 134
TYR A 133
GLY A 214
ASP A 193
GLY A 216
TYR A 188
 None
 1.13A 2qe6A-1htqA:
undetectable		 2qe6A-1htqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 ILE A 382
ALA A 379
GLY A 321
VAL A 340
ARG A 339
 None
 0.83A 2qe6A-1iirA:
3.6		 2qe6A-1iirA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 ILE A 272
ALA A 269
GLY A 217
ASP A 212
GLY A  85
 None
 0.85A 2qe6A-1ir6A:
2.3		 2qe6A-1ir6A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkv HYPOTHETICAL PROTEIN
YJHP

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 GLY A  44
GLY A  46
ASP A  94
VAL A 110
GLY A 111
 None
 0.33A 2qe6A-1nkvA:
10.2		 2qe6A-1nkvA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 136
GLY A  76
ASP A  97
ARG A 102
GLY A 209
 None
 0.83A 2qe6A-1nxkA:
undetectable		 2qe6A-1nxkA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpa LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 ALA A  41
GLY A 113
ASP A  23
VAL A  20
GLY A 106
 None
 0.84A 2qe6A-1qpaA:
undetectable		 2qe6A-1qpaA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi) 		PF03291
(Pox_MCEL) 		5 GLY A  72
GLY A  74
ILE A  95
ASP A 122
TYR A 145
 SAH  A 299 (-3.3A)
SAH  A 299 (-3.5A)
SAH  A 299 (-3.8A)
SAH  A 299 (-3.2A)
SAH  A 299 (-4.2A)
 0.67A 2qe6A-1ri3A:
13.7		 2qe6A-1ri3A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		6 ALA A 455
TYR A 454
GLY A 383
GLY A 376
ASP A 422
GLY A 381
 None
 1.09A 2qe6A-1v7vA:
undetectable		 2qe6A-1v7vA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 ILE A 523
ALA A 522
GLY A 518
ILE A 289
TYR A 661
 None
 0.87A 2qe6A-1w27A:
undetectable		 2qe6A-1w27A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfz NITROGEN FIXATION
CLUSTER-LIKE

(Mus musculus) 		PF01592
(NifU_N) 		5 ALA A 112
GLY A  26
ILE A 110
VAL A  36
GLY A  29
 None
 0.90A 2qe6A-1wfzA:
undetectable		 2qe6A-1wfzA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
brevis) 		PF13561
(adh_short_C2) 		5 ILE A  22
ALA A  21
GLY A  17
ILE A 222
GLY A  13
 None
None
NAI  A1270 (-3.9A)
None
NAI  A1270 (-2.9A)
 0.75A 2qe6A-1zjyA:
6.7		 2qe6A-1zjyA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		6 TYR A  20
GLY A  63
GLY A  65
ASP A 142
VAL A 143
TYR A  11
 SAH  A4001 (-4.2A)
SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 3.8A)
 1.35A 2qe6A-2a14A:
14.0		 2qe6A-2a14A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9u HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Sulfurisphaera
tokodaii) 		PF00908
(dTDP_sugar_isom) 		5 ILE A 112
GLY A 119
ASP A  86
VAL A  87
ARG A  88
 None
 0.84A 2qe6A-2b9uA:
undetectable		 2qe6A-2b9uA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 ALA A 292
GLY A 123
GLY A 287
ASP A 108
GLY A 127
 None
None
None
GMP  A 400 (-3.3A)
None
 0.88A 2qe6A-2fqxA:
undetectable		 2qe6A-2fqxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		6 TYR A  21
GLY A  64
GLY A  66
ASP A 143
VAL A 144
TYR A  12
 SAH  A4001 (-4.5A)
SAH  A4001 (-4.1A)
SAH  A4001 (-3.2A)
SAH  A4001 (-4.0A)
SAH  A4001 (-3.6A)
SAH  A4001 (-3.8A)
 1.27A 2qe6A-2i62A:
15.0		 2qe6A-2i62A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		6 TYR A  20
GLY A  63
GLY A  65
ASP A 142
VAL A 143
TYR A  11
 SAH  A4001 (-4.6A)
SAH  A4001 (-4.0A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
 1.28A 2qe6A-2iipA:
14.4		 2qe6A-2iipA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		6 ALA A  40
GLY A 183
ASP A 141
VAL A 142
ARG A 143
GLY A 200
 ASP  A 502 ( 4.7A)
None
None
None
None
ASP  A 502 (-4.2A)
 1.26A 2qe6A-2j0wA:
undetectable		 2qe6A-2j0wA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		6 ILE A 291
ALA A 286
GLY A 276
ILE A 294
VAL A 252
GLY A 254
 None
 1.32A 2qe6A-2jg5A:
3.8		 2qe6A-2jg5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2leo SERINE PROTEASE
INHIBITOR KAZAL-TYPE
7

(Homo sapiens) 		PF00050
(Kazal_1) 		5 GLY A  61
ILE A  58
ASP A  56
VAL A  77
ARG A  76
 None
 0.90A 2qe6A-2leoA:
undetectable		 2qe6A-2leoA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nm0 PROBABLE
3-OXACYL-(ACYL-CARRI
ER-PROTEIN)
REDUCTASE

(Streptomyces
coelicolor) 		PF13561
(adh_short_C2) 		5 ILE A  18
ALA A  17
GLY A  13
ILE A 204
GLY A   9
 None
 0.88A 2qe6A-2nm0A:
undetectable		 2qe6A-2nm0A:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 TYR A 318
GLY A 101
VAL A 134
VAL A  95
GLY A  94
 None
 0.87A 2qe6A-2o4cA:
undetectable		 2qe6A-2o4cA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF08241
(Methyltransf_11) 		5 GLY A  30
ILE A  53
ASP A  78
ARG A  80
GLY A  96
 GOL  A 213 ( 3.7A)
GOL  A 213 (-4.0A)
None
None
None
 0.63A 2qe6A-2p8jA:
14.4		 2qe6A-2p8jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		5 GLY A  66
GLY A  68
ASP A 113
VAL A 114
GLY A 131
 SAH  A 301 (-3.8A)
SAH  A 301 ( 3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.1A)
 0.35A 2qe6A-2pxxA:
11.0		 2qe6A-2pxxA:
25.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		12 ILE A  22
ALA A  23
TYR A  26
GLY A  84
GLY A  86
ILE A 111
ASP A 135
VAL A 136
ARG A 137
VAL A 163
GLY A 164
TYR A 168
 SAM  A 400 ( 3.7A)
SAM  A 400 (-3.1A)
SAM  A 400 ( 3.8A)
SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.7A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.6A)
SAM  A 400 (-4.2A)
SAM  A 400 (-3.5A)
SAM  A 400 ( 4.5A)
 0.21A 2qe6A-2qe6A:
51.6		 2qe6A-2qe6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvd 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 ILE A  20
ALA A  19
GLY A  15
ILE A 218
GLY A  11
 None
 0.81A 2qe6A-2uvdA:
6.6		 2qe6A-2uvdA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		6 ILE A  96
ALA A 118
TYR A 116
ASP A  44
VAL A  45
VAL A  89
 None
None
None
C2F  A3000 ( 4.5A)
None
None
 1.43A 2qe6A-2ycjA:
undetectable		 2qe6A-2ycjA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 ILE A 272
ALA A 269
GLY A 217
ASP A 212
GLY A  85
 None
 0.90A 2qe6A-2zxoA:
undetectable		 2qe6A-2zxoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 5 ILE A 434
GLY A  14
ILE A 410
GLY A  36
TYR A  39
 None
 0.86A 2qe6A-3a0fA:
undetectable		 2qe6A-3a0fA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 155
GLY A 151
ILE A 158
ARG A 160
GLY A 184
 None
 0.88A 2qe6A-3cyjA:
undetectable		 2qe6A-3cyjA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A 371
ILE A 396
ASP A 414
VAL A 415
GLY A 334
 FAB  A 701 (-3.5A)
FAB  A 701 (-3.8A)
FAB  A 701 (-4.0A)
FAB  A 701 (-3.8A)
None
 0.84A 2qe6A-3e9yA:
2.2		 2qe6A-3e9yA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		5 ILE A  22
ALA A  21
GLY A  17
ILE A 216
GLY A  13
 None
 0.89A 2qe6A-3emkA:
5.9		 2qe6A-3emkA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY A 114
ARG A  69
VAL A 119
GLY A 118
TYR A  66
 None
 0.89A 2qe6A-3fhhA:
undetectable		 2qe6A-3fhhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftp 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		5 ILE A  23
ALA A  22
GLY A  18
ILE A 220
GLY A  14
 None
 0.86A 2qe6A-3ftpA:
6.0		 2qe6A-3ftpA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4s 50S RIBOSOMAL
PROTEIN L6P

(Haloarcula
marismortui) 		PF00347
(Ribosomal_L6) 		5 GLY E  75
GLY E  79
ILE E 138
ARG E  31
GLY E  27
 None
None
U  02781 ( 4.3A)
G  02794 ( 4.5A)
None
 0.86A 2qe6A-3g4sE:
undetectable		 2qe6A-3g4sE:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		5 GLY A   9
ILE A  30
ASP A  51
VAL A  52
GLY A  76
 None
 0.72A 2qe6A-3g7uA:
6.4		 2qe6A-3g7uA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		5 ILE A  27
ALA A  26
GLY A  22
ILE A 224
GLY A  18
 None
 0.78A 2qe6A-3gafA:
6.6		 2qe6A-3gafA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gce FERREDOXIN COMPONENT
OF CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske) 		5 ASP A  80
VAL A  81
ARG A  82
VAL A  24
GLY A  23
 None
 0.81A 2qe6A-3gceA:
undetectable		 2qe6A-3gceA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ged SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Ruminiclostridium
thermocellum) 		PF13561
(adh_short_C2) 		5 GLY A   9
GLY A  11
ILE A  34
ASP A  55
VAL A  56
 THJ  A 249 (-3.4A)
None
THJ  A 249 (-4.5A)
None
None
 0.79A 2qe6A-3gedA:
6.8		 2qe6A-3gedA:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574

(Streptomyces
avermitilis) 		PF04672
(Methyltransf_19) 		5 ALA A  24
TYR A  27
GLY A  85
GLY A  87
ASP A 138
 SAH  A 277 (-3.1A)
SAH  A 277 (-4.3A)
SAH  A 277 (-3.4A)
SAH  A 277 (-3.1A)
SAH  A 277 (-3.5A)
 0.44A 2qe6A-3go4A:
36.4		 2qe6A-3go4A:
40.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grp 3-OXOACYL-(ACYL
CARRIERPROTEIN)
REDUCTASE

(Bartonella
henselae) 		PF13561
(adh_short_C2) 		5 ILE A  22
ALA A  21
GLY A  17
ILE A 216
GLY A  13
 None
 0.78A 2qe6A-3grpA:
2.8		 2qe6A-3grpA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 ILE A 365
ALA A 362
GLY A 304
VAL A 323
ARG A 322
 None
 0.89A 2qe6A-3h4iA:
2.6		 2qe6A-3h4iA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 GLY A 712
GLY A 709
ILE A 723
VAL A 715
GLY A 716
 None
 0.87A 2qe6A-3iayA:
undetectable		 2qe6A-3iayA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icc PUTATIVE
3-OXOACYL-(ACYL
CARRIER PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 ILE A  20
ALA A  19
GLY A  15
ILE A 224
GLY A  11
 ILE  A  20 ( 0.7A)
ALA  A  19 ( 0.0A)
GLY  A  15 ( 0.0A)
ILE  A 224 ( 0.7A)
GLY  A  11 ( 0.0A)
 0.85A 2qe6A-3iccA:
5.6		 2qe6A-3iccA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00106
(adh_short) 		5 ILE A  26
ALA A  25
GLY A  21
ILE A 224
GLY A  17
 None
None
NAP  A 501 (-3.5A)
None
NAP  A 501 (-3.3A)
 0.87A 2qe6A-3kvoA:
6.2		 2qe6A-3kvoA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		5 GLY A  98
GLY A 100
ASP A 171
ARG A 173
TYR A 203
 SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-3.8A)
None
SAM  A 801 (-4.6A)
 0.39A 2qe6A-3o7wA:
16.1		 2qe6A-3o7wA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okx YAEB-LIKE PROTEIN
RPA0152

(Rhodopseudomonas
palustris) 		PF01980
(UPF0066) 		5 ILE A 115
ALA A 116
GLY A  44
GLY A 130
ARG A 103
 None
None
None
None
SAM  A 201 (-4.0A)
 0.88A 2qe6A-3okxA:
undetectable		 2qe6A-3okxA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozx RNASE L INHIBITOR

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		5 ILE A 526
ALA A 527
GLY A 372
ILE A 522
VAL A 482
 None
 0.90A 2qe6A-3ozxA:
undetectable		 2qe6A-3ozxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		6 ALA A  56
GLY A  18
ILE A  43
ASP A  81
VAL A  82
ARG A  83
 NAD  A 277 (-3.3A)
NAD  A 277 (-3.4A)
NAD  A 277 (-3.7A)
NAD  A 277 (-3.5A)
NAD  A 277 (-3.6A)
NAD  A 277 ( 4.7A)
 1.00A 2qe6A-3pgxA:
undetectable		 2qe6A-3pgxA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		6 ALA A  15
GLY A  14
ILE A  38
ASP A  75
VAL A  76
ARG A  77
 NAD  A 284 ( 4.2A)
None
NAD  A 284 (-3.6A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
None
 1.47A 2qe6A-3pxxA:
6.0		 2qe6A-3pxxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		6 ALA A  15
GLY A  14
ILE A  38
ASP A  75
VAL A  76
VAL A 100
 NAD  A 284 ( 4.2A)
None
NAD  A 284 (-3.6A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
None
 1.47A 2qe6A-3pxxA:
6.0		 2qe6A-3pxxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		6 ALA A  50
GLY A  13
ILE A  38
ASP A  75
VAL A  76
ARG A  77
 NAD  A 284 (-3.4A)
NAD  A 284 (-3.4A)
NAD  A 284 (-3.6A)
NAD  A 284 (-3.7A)
NAD  A 284 (-3.5A)
None
 1.11A 2qe6A-3pxxA:
6.0		 2qe6A-3pxxA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkr SHORT CHAIN
OXIDOREDUCTASE

(uncultured
bacterium Bio5) 		PF00106
(adh_short) 		5 ILE A  22
ALA A  21
GLY A  17
ILE A 212
GLY A  13
 None
None
SO4  A 242 (-3.6A)
None
NAP  A 240 (-3.4A)
 0.82A 2qe6A-3rkrA:
5.6		 2qe6A-3rkrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 ILE A  23
ALA A  22
GLY A  18
ILE A 219
GLY A  14
 None
None
NAD  A 251 (-3.4A)
None
NAD  A 251 (-3.4A)
 0.81A 2qe6A-3rwbA:
6.1		 2qe6A-3rwbA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 ALA A  55
GLY A  18
ASP A  80
VAL A  81
ARG A  82
 NAD  A 300 (-3.3A)
NAD  A 300 (-3.4A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.6A)
None
 0.79A 2qe6A-3sx2A:
undetectable		 2qe6A-3sx2A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3two MANNITOL
DEHYDROGENASE

(Helicobacter
pylori) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 296
GLY A 294
ASP A 304
VAL A 303
GLY A  89
 None
 0.89A 2qe6A-3twoA:
4.5		 2qe6A-3twoA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ILE A  20
ALA A  19
GLY A  15
ILE A 217
GLY A  11
 None
 0.79A 2qe6A-3u5tA:
6.1		 2qe6A-3u5tA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 GLY A  14
ILE A  39
ASP A  80
VAL A  81
ARG A  82
 NAD  A 300 (-3.4A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.4A)
NAD  A 300 (-3.6A)
NAD  A 300 ( 4.9A)
 0.87A 2qe6A-3uveA:
undetectable		 2qe6A-3uveA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2g 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ILE A  47
ALA A  46
GLY A  42
ILE A 243
GLY A  38
 None
None
None
None
SO4  A 273 ( 4.9A)
 0.89A 2qe6A-3v2gA:
6.1		 2qe6A-3v2gA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzq ACETOACETYL-COA
REDUCTASE

(Cupriavidus
necator) 		PF00106
(adh_short) 		5 ILE A  19
ALA A  18
GLY A  14
ILE A 217
GLY A  10
 None
 0.87A 2qe6A-3vzqA:
5.8		 2qe6A-3vzqA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtb PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF13561
(adh_short_C2) 		5 ILE A  19
ALA A  18
GLY A  14
ILE A 215
GLY A  10
 None
 0.80A 2qe6A-3wtbA:
5.4		 2qe6A-3wtbA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zv8 3C PROTEASE

(Enterovirus D) 		PF00548
(Peptidase_C3) 		5 ILE A  72
GLY A 148
ILE A  37
VAL A 151
GLY A 159
 None
 0.88A 2qe6A-3zv8A:
undetectable		 2qe6A-3zv8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		5 ILE B 201
ASP B 215
VAL B 216
ARG B 217
VAL B 159
 None
 0.68A 2qe6A-4a11B:
undetectable		 2qe6A-4a11B:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 121
GLY A  57
ASP A  17
VAL A  18
GLY A 364
 None
 0.88A 2qe6A-4a35A:
undetectable		 2qe6A-4a35A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bo6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 ILE A  21
ALA A  20
GLY A  16
ILE A 218
GLY A  12
 None
 0.83A 2qe6A-4bo6A:
5.9		 2qe6A-4bo6A:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 ILE A 291
ALA A 296
ASP A 226
VAL A 227
ARG A 228
 None
 0.84A 2qe6A-4dioA:
5.6		 2qe6A-4dioA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		6 ALA A  53
GLY A 312
GLY A 309
VAL A 316
VAL A 125
GLY A 102
 None
 1.29A 2qe6A-4eygA:
undetectable		 2qe6A-4eygA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn4 SHORT CHAIN
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF13561
(adh_short_C2) 		5 ILE A  24
ALA A  23
GLY A  19
ILE A 226
GLY A  15
 None
None
NAD  A 501 (-3.3A)
None
NAD  A 501 (-3.2A)
 0.85A 2qe6A-4fn4A:
6.6		 2qe6A-4fn4A:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvx 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Burkholderia
multivorans) 		PF13561
(adh_short_C2) 		5 ILE A  23
ALA A  22
GLY A  18
ILE A 224
GLY A  14
 None
None
NAP  A 301 (-3.5A)
None
NAP  A 301 (-3.2A)
 0.83A 2qe6A-4gvxA:
6.1		 2qe6A-4gvxA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		5 GLY A  43
GLY A  40
VAL A 288
VAL A 464
GLY A 463
 None
FAD  A 501 (-3.5A)
None
None
FAD  A 501 ( 4.5A)
 0.75A 2qe6A-4i59A:
undetectable		 2qe6A-4i59A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		5 ILE A  23
ALA A  22
GLY A  18
ILE A 226
GLY A  14
 None
None
NAI  A 301 (-3.5A)
None
NAI  A 301 (-3.3A)
 0.78A 2qe6A-4ituA:
4.5		 2qe6A-4ituA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		6 ILE A  17
ALA A  73
GLY A 225
ASP A 135
ARG A 227
VAL A  10
 None
None
None
EDO  A 718 (-3.1A)
EDO  A 718 ( 4.8A)
None
 1.29A 2qe6A-4jclA:
undetectable		 2qe6A-4jclA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m73 METHYLTRANSFERASE
MPPJ

(Streptomyces
hygroscopicus) 		PF13649
(Methyltransf_25) 		6 ALA A 194
GLY A 166
GLY A 168
ILE A 190
ASP A 217
ARG A 219
 SAH  A 401 ( 3.8A)
SAH  A 401 (-3.4A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.7A)
SAH  A 401 (-4.5A)
 1.36A 2qe6A-4m73A:
15.1		 2qe6A-4m73A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m73 METHYLTRANSFERASE
MPPJ

(Streptomyces
hygroscopicus) 		PF13649
(Methyltransf_25) 		6 ILE A 195
ALA A 194
GLY A 170
GLY A 168
VAL A 202
GLY A 187
 None
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
None
None
 1.09A 2qe6A-4m73A:
15.1		 2qe6A-4m73A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		5 ILE A  24
ALA A  23
GLY A  19
ILE A 219
GLY A  15
 None
 0.81A 2qe6A-4m8sA:
6.3		 2qe6A-4m8sA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mow GLUCOSE
1-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 ILE A  22
ALA A  21
GLY A  17
ILE A 221
GLY A  13
 None
 0.81A 2qe6A-4mowA:
6.1		 2qe6A-4mowA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 ILE A1260
ALA A1254
TYR A1256
GLY A1252
VAL A1272
 None
 0.85A 2qe6A-4n1aA:
undetectable		 2qe6A-4n1aA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Acholeplasma
laidlawii) 		PF13561
(adh_short_C2) 		5 ILE A  22
ALA A  21
GLY A  17
ILE A 212
GLY A  13
 None
None
NAD  A 301 (-3.4A)
None
NAD  A 301 (-3.0A)
 0.86A 2qe6A-4nbtA:
6.1		 2qe6A-4nbtA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oso REDUCTASE HOMOLOG

(Streptomyces
cyanogenus) 		PF13561
(adh_short_C2) 		5 ILE A  22
ALA A  21
GLY A  17
ILE A 224
GLY A  13
 None
None
NAP  A 301 (-3.6A)
None
NAP  A 301 (-3.2A)
 0.88A 2qe6A-4osoA:
5.8		 2qe6A-4osoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qa9 EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 ILE A 169
ALA A 170
ILE A  94
VAL A 328
GLY A 327
 None
 0.89A 2qe6A-4qa9A:
undetectable		 2qe6A-4qa9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		6 ALA A 235
GLY A 188
GLY A 236
ILE A 142
VAL A 167
GLY A 346
 None
 1.46A 2qe6A-4r8eA:
undetectable		 2qe6A-4r8eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF13487
(HD_5) 		5 ALA A 278
GLY A 223
GLY A 253
ASP A 171
GLY A 248
 None
None
None
NI  A 401 ( 4.5A)
None
 0.89A 2qe6A-4r8zA:
undetectable		 2qe6A-4r8zA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
kefiri) 		PF13561
(adh_short_C2) 		5 ILE A  23
ALA A  22
GLY A  18
ILE A 223
GLY A  14
 None
 0.82A 2qe6A-4rf3A:
6.7		 2qe6A-4rf3A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 GLY A 103
GLY A  32
ASP A 109
VAL A 125
GLY A 126
 None
PO4  A 301 ( 3.7A)
None
None
None
 0.89A 2qe6A-4rncA:
undetectable		 2qe6A-4rncA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 ILE B  24
ALA B  23
GLY B  19
ILE B 211
GLY B  15
 None
 0.80A 2qe6A-4rziB:
6.0		 2qe6A-4rziB:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		5 GLY A 642
ASP A 686
VAL A 687
ARG A 688
GLY A 707
 SAH  A1004 (-3.3A)
SAH  A1004 (-3.0A)
SAH  A1004 (-3.7A)
SAH  A1004 (-4.4A)
None
 0.68A 2qe6A-4u7tA:
5.5		 2qe6A-4u7tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		5 GLY A  45
GLY A  47
ASP A  95
VAL A 111
GLY A 112
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.3A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 4.7A)
 0.44A 2qe6A-5bp7A:
9.7		 2qe6A-5bp7A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ALA A 392
ILE A 164
ASP A 193
VAL A 322
GLY A 323
 None
KCX  A 191 ( 4.1A)
MG  A 501 (-2.9A)
None
None
 0.85A 2qe6A-5c2cA:
undetectable		 2qe6A-5c2cA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cej 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Yersinia pestis) 		PF13561
(adh_short_C2) 		5 ILE A  21
ALA A  20
GLY A  16
ILE A 215
GLY A  12
 None
 0.76A 2qe6A-5cejA:
5.9		 2qe6A-5cejA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		5 GLY A 205
GLY A 207
ILE A 228
ASP A 261
TYR A 289
 SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.8A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
 0.80A 2qe6A-5e9jA:
14.9		 2qe6A-5e9jA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej2 CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 GLY A  22
ILE A  47
ASP A  84
VAL A  85
ARG A  86
 NAD  A 300 (-3.5A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.3A)
NAD  A 300 (-3.6A)
NAD  A 300 ( 4.8A)
 0.83A 2qe6A-5ej2A:
undetectable		 2qe6A-5ej2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5end 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Vibrio cholerae) 		PF13561
(adh_short_C2) 		5 ILE A  25
ALA A  24
GLY A  20
ILE A 219
GLY A  16
 None
 0.73A 2qe6A-5endA:
6.5		 2qe6A-5endA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		5 GLY A  44
GLY A  46
ASP A  94
VAL A 110
GLY A 111
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.2A)
SAH  A 301 (-4.9A)
 0.52A 2qe6A-5epeA:
8.0		 2qe6A-5epeA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jab BILIVERDIN REDUCTASE
RV2074

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		6 ALA A 100
TYR A 104
ILE A  50
VAL A 122
VAL A  40
GLY A  41
 None
None
None
None
6J4  A 201 (-4.2A)
6J4  A 201 (-3.9A)
 1.48A 2qe6A-5jabA:
undetectable		 2qe6A-5jabA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je3 METHYL TRANSFERASE

(Burkholderia
glumae) 		PF13847
(Methyltransf_31) 		5 GLY A  49
ILE A  70
ASP A  95
VAL A  96
TYR A 116
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.0A)
 0.71A 2qe6A-5je3A:
13.3		 2qe6A-5je3A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy1 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		5 GLY A  13
GLY A  15
ILE A  38
ASP A  63
VAL A  64
 NAD  A 301 (-3.4A)
NAD  A 301 ( 4.2A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.8A)
NAD  A 301 (-3.6A)
 0.81A 2qe6A-5jy1A:
5.2		 2qe6A-5jy1A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021

(Burkholderia
pseudomallei) 		PF00282
(Pyridoxal_deC) 		6 ILE A 222
ALA A 221
GLY A 217
ASP A 186
VAL A 185
VAL A 232
 None
 1.17A 2qe6A-5k1rA:
undetectable		 2qe6A-5k1rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ASN A 152
ARG A 131
ASP A 379
 None
 0.92A 2qe6A-1d6mA:
undetectable		 2qe6A-1d6mA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ASN A 175
ARG A 178
ASP A  55
 None
 0.98A 2qe6A-1d6mA:
undetectable		 2qe6A-1d6mA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)

(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9)
PF02256
(Fe_hyd_SSU) 		3 ASN D 110
ARG D 112
ASP A  39
 None
 0.97A 2qe6A-1e08D:
undetectable		 2qe6A-1e08D:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcu HYALURONOGLUCOSAMINI
DASE

(Apis mellifera) 		PF01630
(Glyco_hydro_56) 		3 ASN A 321
ARG A 317
ASP A  44
 None
 0.90A 2qe6A-1fcuA:
undetectable		 2qe6A-1fcuA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)

(Planomicrobium
okeanokoites) 		PF02980
(FokI_C)
PF02981
(FokI_N)
PF09254
(Endonuc-FokI_C)
PF16902
(Type2_restr_D3) 		3 ASN A 502
ARG A 447
ASP A 467
 None
 0.98A 2qe6A-1fokA:
undetectable		 2qe6A-1fokA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 ASN A  61
ARG A  63
ASP A 456
 None
 0.94A 2qe6A-1kcxA:
undetectable		 2qe6A-1kcxA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjv MATURE ALPHA CHAIN
OF MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
ANTIGEN (HEAVY
CHAIN)

(Rattus
norvegicus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ASN A  42
ARG A  35
ASP A   9
 None
 0.88A 2qe6A-1kjvA:
undetectable		 2qe6A-1kjvA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovw ENDOGLUCANASE I

(Fusarium
oxysporum) 		PF00840
(Glyco_hydro_7) 		3 ASN A 242
ARG A 245
ASP A 352
 None
 0.78A 2qe6A-1ovwA:
undetectable		 2qe6A-1ovwA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p50 ARGININE KINASE

(Limulus
polyphemus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 274
ARG A 330
ASP A 324
 NO3  A 401 (-3.1A)
None
ADP  A 400 (-3.7A)
 0.93A 2qe6A-1p50A:
undetectable		 2qe6A-1p50A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 285
ARG A 340
ASP A 334
 None
None
ADP  A1801 (-3.3A)
 0.94A 2qe6A-1u6rA:
undetectable		 2qe6A-1u6rA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		3 ASN B 865
ARG B 868
ASP B 911
 None
 0.98A 2qe6A-1uw4B:
undetectable		 2qe6A-1uw4B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		3 ASN A 197
ARG A 232
ASP A 157
 CXY  A 401 (-2.9A)
CXY  A 401 (-3.5A)
None
 0.87A 2qe6A-1wvgA:
undetectable		 2qe6A-1wvgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		3 ASN A 256
ARG A 257
ASP A 314
 None
 0.85A 2qe6A-1yniA:
undetectable		 2qe6A-1yniA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		3 ASN A 256
ARG A 289
ASP A 217
 None
 0.95A 2qe6A-2c20A:
4.7		 2qe6A-2c20A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT
DIOL
DEHYDRATASE-REACTIVA
TING FACTOR SMALL
SUBUNIT

(Klebsiella
oxytoca;
Klebsiella
oxytoca) 		PF08841
(DDR)
PF02288
(Dehydratase_MU) 		3 ASN B  97
ARG B  96
ASP A 183
 None
None
MG  A1005 (-2.7A)
 0.86A 2qe6A-2d0oB:
undetectable		 2qe6A-2d0oB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvq HYPOTHETICAL 37.6
KDA PROTEIN IN
GP24-HOC INTERGENIC
REGION

(Escherichia
virus T4) 		PF09414
(RNA_ligase) 		3 ASN A 269
ARG A 266
ASP A 110
 None
 0.75A 2qe6A-2hvqA:
undetectable		 2qe6A-2hvqA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocx NODULATION
FUCOSYLTRANSFERASE
NODZ

(Bradyrhizobium
sp. WM9) 		PF05830
(NodZ) 		3 ASN A  52
ARG A  41
ASP A 129
 None
 0.69A 2qe6A-2ocxA:
2.7		 2qe6A-2ocxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ASN A 138
ARG A 136
ASP A 117
 None
 0.98A 2qe6A-2q27A:
3.8		 2qe6A-2q27A:
18.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		3 ASN A  60
ARG A  61
ASP A 110
 SAM  A 400 ( 3.5A)
SAM  A 400 (-3.7A)
SAM  A 400 (-2.7A)
 0.00A 2qe6A-2qe6A:
51.6		 2qe6A-2qe6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qj8 MLR6093 PROTEIN

(Mesorhizobium
japonicum) 		PF04952
(AstE_AspA) 		3 ASN A  97
ARG A  96
ASP A 138
 None
 0.96A 2qe6A-2qj8A:
undetectable		 2qe6A-2qj8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		3 ASN A 143
ARG A 149
ASP A 157
 None
 0.99A 2qe6A-2wrzA:
undetectable		 2qe6A-2wrzA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens;
Homo sapiens) 		PF00069
(Pkinase)
PF00069
(Pkinase) 		3 ASN B 252
ARG C 331
ASP B 365
 None
 1.00A 2qe6A-2wtkB:
undetectable		 2qe6A-2wtkB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		3 ASN A 241
ARG A 198
ASP A 258
 None
 0.91A 2qe6A-2yn0A:
2.1		 2qe6A-2yn0A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		3 ASN A 231
ARG A 240
ASP A 167
 None
 0.93A 2qe6A-2zblA:
undetectable		 2qe6A-2zblA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		3 ASN A 301
ARG A 304
ASP A 316
 None
 0.98A 2qe6A-2zq5A:
undetectable		 2qe6A-2zq5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER

(Escherichia
coli) 		PF03797
(Autotransporter) 		3 ASN A1372
ARG A1121
ASP A1197
 None
 0.99A 2qe6A-3aehA:
undetectable		 2qe6A-3aehA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		3 ASN C 152
ARG C 132
ASP C 323
 None
GSU  C1001 (-2.2A)
GSU  C1001 (-3.0A)
 0.95A 2qe6A-3al0C:
undetectable		 2qe6A-3al0C:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czq PUTATIVE
POLYPHOSPHATE KINASE
2

(Sinorhizobium
meliloti) 		PF03976
(PPK2) 		3 ASN A 196
ARG A  92
ASP A  22
 None
 0.93A 2qe6A-3czqA:
undetectable		 2qe6A-3czqA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dev SH1221

(Staphylococcus
haemolyticus) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 ASN A  86
ARG A  89
ASP A  27
 None
None
MG  A 323 ( 4.1A)
 0.98A 2qe6A-3devA:
1.8		 2qe6A-3devA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 3 ASN A 166
ARG A 167
ASP A 141
 None
 0.89A 2qe6A-3dsmA:
undetectable		 2qe6A-3dsmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2s PROLINE
DEHYDROGENASE

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 ASN A 563
ARG A 569
ASP A 463
 None
None
FAD  A2001 ( 4.1A)
 0.82A 2qe6A-3e2sA:
1.8		 2qe6A-3e2sA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo5 RESUSCITATION-PROMOT
ING FACTOR RPFB

(Mycobacterium
tuberculosis) 		PF06737
(Transglycosylas)
PF07501
(G5) 		3 ASN A 219
ARG A 222
ASP A 329
 None
 0.96A 2qe6A-3eo5A:
undetectable		 2qe6A-3eo5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fok UNCHARACTERIZED
PROTEIN CGL0159

(Corynebacterium
glutamicum) 		no annotation 3 ASN A 195
ARG A 150
ASP A  50
 None
 0.81A 2qe6A-3fokA:
undetectable		 2qe6A-3fokA:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574

(Streptomyces
avermitilis) 		PF04672
(Methyltransf_19) 		3 ASN A  61
ARG A  62
ASP A 111
 SAH  A 277 (-3.5A)
SAH  A 277 (-4.0A)
SAH  A 277 (-2.7A)
 0.61A 2qe6A-3go4A:
36.4		 2qe6A-3go4A:
40.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0z PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Streptococcus
pneumoniae) 		PF01380
(SIS) 		3 ASN A 171
ARG A 117
ASP A 366
 None
 0.91A 2qe6A-3i0zA:
2.0		 2qe6A-3i0zA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju5 ARGININE KINASE

(Apostichopus
japonicus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 277
ARG A 332
ASP A 326
 None
 0.89A 2qe6A-3ju5A:
undetectable		 2qe6A-3ju5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 ASN A  29
ARG A 176
ASP A 102
 None
 0.61A 2qe6A-3k1dA:
undetectable		 2qe6A-3k1dA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7i TEICHOIC ACID
BIOSYNTHESIS PROTEIN
F

(Staphylococcus
epidermidis) 		PF04464
(Glyphos_transf) 		3 ASN A 517
ARG A 518
ASP A 608
 None
 0.97A 2qe6A-3l7iA:
undetectable		 2qe6A-3l7iA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maz SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 1

(Homo sapiens) 		PF00017
(SH2) 		3 ASN A 199
ARG A 216
ASP A 220
 None
 0.98A 2qe6A-3mazA:
undetectable		 2qe6A-3mazA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Clostridium
novyi) 		PF01380
(SIS) 		3 ASN A 170
ARG A 116
ASP A 371
 None
 0.98A 2qe6A-3odpA:
undetectable		 2qe6A-3odpA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		3 ASN A  93
ARG A 248
ASP A  43
 None
 0.81A 2qe6A-3p2mA:
undetectable		 2qe6A-3p2mA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbi INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		3 ASN A  57
ARG A 169
ASP A 142
 None
 0.93A 2qe6A-3pbiA:
undetectable		 2qe6A-3pbiA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 ASN A  58
ARG A 179
ASP A 186
 None
 0.83A 2qe6A-3pqsA:
undetectable		 2qe6A-3pqsA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slt SERINE PROTEASE ESPP

(Escherichia
coli) 		PF03797
(Autotransporter) 		3 ASN A1295
ARG A1044
ASP A1120
 None
 0.96A 2qe6A-3sltA:
undetectable		 2qe6A-3sltA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		3 ASN A 325
ARG A 326
ASP A 158
 None
MG  A 500 (-3.3A)
None
 0.88A 2qe6A-3t5tA:
3.6		 2qe6A-3t5tA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		3 ASN A  77
ARG A  78
ASP A 268
 EB4  A 328 (-3.5A)
EB4  A 328 ( 3.5A)
None
 0.94A 2qe6A-3tlkA:
undetectable		 2qe6A-3tlkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acz ENDO-ALPHA-MANNOSIDA
SE

(Bacteroides
thetaiotaomicron) 		PF16317
(Glyco_hydro_99) 		3 ASN B 294
ARG B 291
ASP B 194
 None
 0.96A 2qe6A-4aczB:
undetectable		 2qe6A-4aczB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhl ARGININE KINASE

(Litopenaeus
vannamei) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 274
ARG A 330
ASP A 324
 ARG  A 400 ( 4.5A)
None
None
 0.93A 2qe6A-4bhlA:
undetectable		 2qe6A-4bhlA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btf MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 ASN A  33
ARG A  30
ASP A 143
 None
 0.92A 2qe6A-4btfA:
undetectable		 2qe6A-4btfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz2 FAB 2D73 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASN H  33
ARG H  99
ASP H 104
 None
PEG  H 226 (-3.0A)
None
 0.89A 2qe6A-4bz2H:
undetectable		 2qe6A-4bz2H:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		3 ASN A 230
ARG A 474
ASP A 434
 None
None
CD  A1983 (-2.3A)
 0.93A 2qe6A-4cvuA:
1.7		 2qe6A-4cvuA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d51 CYMA

(Klebsiella
oxytoca) 		PF16941
(CymA) 		3 ASN A 156
ARG A 139
ASP A   3
 None
 0.89A 2qe6A-4d51A:
undetectable		 2qe6A-4d51A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		3 ASN A 582
ARG A 585
ASP A 529
 None
 0.84A 2qe6A-4etpA:
undetectable		 2qe6A-4etpA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj4 UNCHARACTERIZED
PROTEIN

(Halobacterium
salinarum) 		PF07920
(DUF1684) 		3 ASN A 156
ARG A 132
ASP A 123
 None
 0.97A 2qe6A-4fj4A:
undetectable		 2qe6A-4fj4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ASN A 378
ARG A 381
ASP A 858
 SO4  A1016 ( 4.0A)
None
None
 0.78A 2qe6A-4fysA:
undetectable		 2qe6A-4fysA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h96 DIHYDROFOLATE
REDUCTASE

(Candida
albicans) 		PF00186
(DHFR_1) 		3 ASN A  50
ARG A 108
ASP A 170
 None
 0.98A 2qe6A-4h96A:
undetectable		 2qe6A-4h96A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		3 ASN A 209
ARG A 206
ASP A  13
 None
 0.82A 2qe6A-4hpvA:
undetectable		 2qe6A-4hpvA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP
EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		PF02128
(Peptidase_M36)
PF07504
(FTP) 		3 ASN A 383
ARG A 407
ASP B 218
 None
 0.94A 2qe6A-4k90A:
undetectable		 2qe6A-4k90A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ASN B 310
ARG B 313
ASP B 400
 None
 0.95A 2qe6A-4l37B:
undetectable		 2qe6A-4l37B:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6f DNA-INVERTASE

(Escherichia
virus Mu) 		PF00239
(Resolvase)
PF02796
(HTH_7) 		3 ASN A  14
ARG A  65
ASP A  33
 None
 0.94A 2qe6A-4m6fA:
undetectable		 2qe6A-4m6fA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 ASN A 135
ARG A 129
ASP A  58
 None
 0.98A 2qe6A-4pdxA:
undetectable		 2qe6A-4pdxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pke PROTEIN C10C5.1,
ISOFORM I

(Caenorhabditis
elegans) 		PF12166
(Piezo_RRas_bdg) 		3 ASN A 109
ARG A 108
ASP A 168
 None
 0.96A 2qe6A-4pkeA:
undetectable		 2qe6A-4pkeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5t LIPOPROTEIN

(Streptococcus
mutans) 		PF03180
(Lipoprotein_9) 		3 ASN A 147
ARG A 150
ASP A 276
 None
 0.97A 2qe6A-4q5tA:
undetectable		 2qe6A-4q5tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans) 		PF00514
(Arm) 		3 ASN A 360
ARG A 404
ASP A 552
 None
 0.93A 2qe6A-4r10A:
undetectable		 2qe6A-4r10A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s24 MODULATOR OF DRUG
ACTIVITY B

(Yersinia pestis) 		PF02525
(Flavodoxin_2) 		3 ASN A 169
ARG A 129
ASP A 145
 None
None
PEG  A 203 (-3.2A)
 0.89A 2qe6A-4s24A:
undetectable		 2qe6A-4s24A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uq9 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF17189
(Glyco_hydro_30C) 		3 ASN A 124
ARG A  67
ASP A  26
 None
 0.95A 2qe6A-4uq9A:
undetectable		 2qe6A-4uq9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utf GLYCOSYL HYDROLASE
FAMILY 71

(Bacteroides
xylanisolvens) 		PF16317
(Glyco_hydro_99) 		3 ASN A 298
ARG A 295
ASP A 196
 MAN  A 511 (-3.4A)
MAN  A 511 ( 3.1A)
MAN  A 510 (-2.8A)
 0.90A 2qe6A-4utfA:
undetectable		 2qe6A-4utfA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 271
ARG A 326
ASP A 320
 NO3  A 807 ( 3.2A)
None
ADP  A 801 (-3.9A)
 0.89A 2qe6A-4woeA:
undetectable		 2qe6A-4woeA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		3 ASN B 368
ARG B 371
ASP B 161
 None
 0.92A 2qe6A-4wvmB:
undetectable		 2qe6A-4wvmB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		3 ASN A 224
ARG A 225
ASP A 238
 None
 0.93A 2qe6A-4xnuA:
undetectable		 2qe6A-4xnuA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		3 ASN A 377
ARG A 373
ASP A1454
 None
 1.00A 2qe6A-4yknA:
undetectable		 2qe6A-4yknA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		3 ASN A  45
ARG A 462
ASP A 457
 None
 0.93A 2qe6A-4zxlA:
undetectable		 2qe6A-4zxlA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		3 ASN A 364
ARG A 367
ASP A 425
 None
 0.96A 2qe6A-5a01A:
undetectable		 2qe6A-5a01A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis) 		PF01425
(Amidase) 		3 ASN A 416
ARG A 423
ASP A 165
 None
 0.99A 2qe6A-5ewqA:
undetectable		 2qe6A-5ewqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASN A  78
ARG A 227
ASP A 176
 None
 0.84A 2qe6A-5fr8A:
undetectable		 2qe6A-5fr8A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		3 ASN A  45
ARG A  70
ASP A 426
 None
EDO  A 510 (-3.8A)
None
 0.83A 2qe6A-5inrA:
undetectable		 2qe6A-5inrA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdu RPB7-BINDING PROTEIN
SEB1

(Schizosaccharomyces
pombe) 		PF00076
(RRM_1) 		3 ASN A 463
ARG A 472
ASP A 468
 None
NA  A 603 (-4.3A)
None
 0.97A 2qe6A-5mduA:
undetectable		 2qe6A-5mduA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03147
(FDX-ACB) 		3 ASN A 111
ARG A 112
ASP A  91
 None
 0.97A 2qe6A-5mgvA:
undetectable		 2qe6A-5mgvA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		3 ASN B 316
ARG B 317
ASP B 473
 None
 1.00A 2qe6A-5mrwB:
3.6		 2qe6A-5mrwB:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 ASN A 309
ARG A 298
ASP A 291
 None
 0.99A 2qe6A-5mvhA:
undetectable		 2qe6A-5mvhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		3 ASN A 230
ARG A 110
ASP A 971
 None
EDO  A1615 (-2.9A)
None
 0.99A 2qe6A-5mzoA:
undetectable		 2qe6A-5mzoA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 3 ASN A 464
ARG A 467
ASP A 408
 None
 0.98A 2qe6A-5ng6A:
undetectable		 2qe6A-5ng6A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 3 ASN A 325
ARG A 328
ASP A 420
 None
 0.76A 2qe6A-5nprA:
undetectable		 2qe6A-5nprA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 3 ASN A 316
ARG A 319
ASP A 260
 None
 0.98A 2qe6A-5oasA:
undetectable		 2qe6A-5oasA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 3 ASN A 193
ARG A 196
ASP A 577
 None
 0.63A 2qe6A-5opqA:
undetectable		 2qe6A-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oq3 CWP19

(Clostridioides
difficile) 		no annotation 3 ASN A 355
ARG A 356
ASP A 381
 None
 0.97A 2qe6A-5oq3A:
undetectable		 2qe6A-5oq3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB

(Geobacter
metallireducens) 		PF00437
(T2SSE) 		3 ASN A 433
ARG A 430
ASP A 423
 None
 0.80A 2qe6A-5tshA:
undetectable		 2qe6A-5tshA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8e ARGININE KINASE

(Polybetes
pythagoricus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 274
ARG A 330
ASP A 324
 None
 0.98A 2qe6A-5u8eA:
undetectable		 2qe6A-5u8eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		3 ASN A  17
ARG A  18
ASP A 317
 None
G6P  A 502 (-3.8A)
None
 0.98A 2qe6A-5v0tA:
undetectable		 2qe6A-5v0tA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyq UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		3 ASN A  86
ARG A  90
ASP A 114
 None
 0.90A 2qe6A-5vyqA:
undetectable		 2qe6A-5vyqA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 3 ASN A 216
ARG A 207
ASP A 747
 None
 0.89A 2qe6A-5weaA:
undetectable		 2qe6A-5weaA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 3 ASN A 186
ARG A 185
ASP A 384
 None
 0.97A 2qe6A-5wmmA:
12.5		 2qe6A-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		3 ASN O 687
ARG O 684
ASP O 743
 None
 0.95A 2qe6A-5x0yO:
2.0		 2qe6A-5x0yO:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 3 ASN A 399
ARG A 402
ASP A  67
 None
 0.93A 2qe6A-5ykbA:
undetectable		 2qe6A-5ykbA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b1z GLUTAMATE--TRNA
LIGASE

(Elizabethkingia
anophelis) 		PF00749
(tRNA-synt_1c) 		3 ASN A 136
ARG A 135
ASP A 102
 None
 1.00A 2qe6A-6b1zA:
undetectable		 2qe6A-6b1zA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byf TYROSINE-PROTEIN
PHOSPHATASE SIW14

(Saccharomyces
cerevisiae) 		no annotation 3 ASN A 121
ARG A 131
ASP A 255
 None
 0.95A 2qe6A-6byfA:
undetectable		 2qe6A-6byfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 ASN H 619
ARG H 616
ASP H 609
 None
 0.90A 2qe6A-6chsH:
undetectable		 2qe6A-6chsH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2v TERB OXIDOREDUCTASE

(Streptomyces) 		no annotation 3 ASN A 235
ARG A 171
ASP A 136
 None
 0.80A 2qe6A-6d2vA:
4.9		 2qe6A-6d2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 3 ASN A 158
ARG A  98
ASP A 356
 None
None
PO4  A 601 ( 4.9A)
 0.89A 2qe6A-6dd3A:
undetectable		 2qe6A-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dw1


(;
) 		no annotation
no annotation 		3 ASN E 113
ARG E 129
ASP D 148
 None
 0.84A 2qe6A-6dw1E:
undetectable		 2qe6A-6dw1E:
undetectable