SIMILAR PATTERNS OF AMINO ACIDS FOR 2QD5_B_CHDB1103

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		4 LEU A 366
SER A  15
VAL A  19
GLY A  51
 None
 1.11A 2qd5B-1dkpA:
undetectable		 2qd5B-1dkpA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 LEU A 390
PRO A 402
VAL A 298
GLY A 358
 None
 1.06A 2qd5B-1e1cA:
5.7		 2qd5B-1e1cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecx AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00266
(Aminotran_5) 		4 LEU A  57
ARG A  50
VAL A 210
GLY A 211
 None
 1.08A 2qd5B-1ecxA:
undetectable		 2qd5B-1ecxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		4 MET A 250
LEU A 254
GLY A  54
MET A 233
 None
None
ATP  A1433 (-3.4A)
None
 0.93A 2qd5B-1h3eA:
2.2		 2qd5B-1h3eA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1

(Streptomyces
coelicolor) 		PF01183
(Glyco_hydro_25) 		4 LEU A 209
PRO A 159
VAL A  96
GLY A  95
 None
 0.88A 2qd5B-1jfxA:
undetectable		 2qd5B-1jfxA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		4 MET A  15
LEU A  17
PRO A 202
GLY A 205
 None
 1.05A 2qd5B-1ktnA:
undetectable		 2qd5B-1ktnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 LEU A 398
PRO A 209
VAL A 290
GLY A 291
 None
 0.86A 2qd5B-1lnsA:
2.0		 2qd5B-1lnsA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 LEU A 354
VAL A 257
GLY A 256
MET A 430
 None
 1.07A 2qd5B-1mb9A:
undetectable		 2qd5B-1mb9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 LEU A 408
VAL A 257
GLY A 256
MET A 430
 None
 0.88A 2qd5B-1mb9A:
undetectable		 2qd5B-1mb9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU A 307
VAL A 295
GLY A 296
MET A 206
 None
 1.06A 2qd5B-1ofuA:
4.5		 2qd5B-1ofuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 MET A 189
LEU A 381
SER A 216
VAL A 212
 None
None
MGD  A1804 (-2.3A)
None
 0.97A 2qd5B-1ogyA:
1.8		 2qd5B-1ogyA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjw ENVELOPE PROTEIN

(Japanese
encephalitis
virus) 		PF02832
(Flavi_glycop_C) 		4 LEU A  35
PRO A  85
SER A  90
VAL A  64
 None
 1.06A 2qd5B-1pjwA:
undetectable		 2qd5B-1pjwA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 LEU A  99
ARG A 145
VAL A  66
GLY A  65
 None
CL  A 706 ( 4.0A)
None
None
 0.89A 2qd5B-1ps9A:
undetectable		 2qd5B-1ps9A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v47 ATP SULFURYLASE

(Thermus
thermophilus) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 MET A  45
LEU A 278
ARG A 273
GLY A 234
 CL  A 608 ( 4.2A)
None
None
None
 1.03A 2qd5B-1v47A:
3.4		 2qd5B-1v47A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 LEU A 152
ARG A 172
VAL A  76
GLY A 145
 None
 0.86A 2qd5B-1v9pA:
undetectable		 2qd5B-1v9pA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 4 LEU A  40
PRO A 123
SER A  97
GLY A  89
 None
 1.11A 2qd5B-1wwlA:
undetectable		 2qd5B-1wwlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		4 ARG A 212
PRO A 322
GLY A 361
MET A 357
 SUG  A1001 (-3.0A)
None
SUG  A1001 ( 4.2A)
None
 1.04A 2qd5B-1yniA:
undetectable		 2qd5B-1yniA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 MET A 410
LEU A 407
SER A 415
GLY A 332
 None
 1.00A 2qd5B-1zkcA:
undetectable		 2qd5B-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 315
SER A  15
VAL A 426
GLY A 401
 ADP  A1482 (-4.9A)
None
None
ADP  A1482 ( 3.9A)
 1.07A 2qd5B-2cgjA:
undetectable		 2qd5B-2cgjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj1 PROTEIN
DISULFIDE-ISOMERASE
A4

(Mus musculus) 		PF00085
(Thioredoxin) 		4 LEU A  83
PRO A 137
SER A 135
GLY A 101
 None
 0.87A 2qd5B-2dj1A:
3.1		 2qd5B-2dj1A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		4 ARG A 277
PRO A 186
VAL A 189
GLY A 180
 None
 1.07A 2qd5B-2e3zA:
undetectable		 2qd5B-2e3zA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		4 ARG A 172
PRO A 107
VAL A 139
GLY A 138
 None
 0.95A 2qd5B-2gjnA:
undetectable		 2qd5B-2gjnA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		4 LEU A 260
SER A 208
VAL A 234
GLY A 233
 None
 1.08A 2qd5B-2h8xA:
undetectable		 2qd5B-2h8xA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF03054
(tRNA_Me_trans) 		4 MET A 142
LEU A 164
VAL A 347
GLY A 357
 None
 0.85A 2qd5B-2hmaA:
2.2		 2qd5B-2hmaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 MET A 153
LEU A 157
VAL A  75
GLY A  96
 None
 0.99A 2qd5B-2hxoA:
undetectable		 2qd5B-2hxoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		4 LEU A 183
SER A 156
VAL A 359
GLY A 165
 None
 1.11A 2qd5B-2i3oA:
undetectable		 2qd5B-2i3oA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfg EH DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF12763
(EF-hand_4) 		4 PRO A 132
SER A 134
VAL A  46
GLY A  47
 None
 0.52A 2qd5B-2kfgA:
undetectable		 2qd5B-2kfgA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2os3 PEPTIDE DEFORMYLASE

(Streptococcus
pyogenes) 		PF01327
(Pep_deformylase) 		4 LEU A 205
ARG A 144
VAL A  87
GLY A  72
 None
None
None
BB2  A 400 (-4.6A)
 0.74A 2qd5B-2os3A:
undetectable		 2qd5B-2os3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa4 UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00483
(NTP_transferase) 		4 LEU A 248
ARG A 222
VAL A 122
GLY A 123
 None
 0.93A 2qd5B-2pa4A:
undetectable		 2qd5B-2pa4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pia PHTHALATE
DIOXYGENASE
REDUCTASE

(Burkholderia
cepacia) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ARG A 209
PRO A 125
SER A  58
GLY A 200
 None
None
FMN  A 322 (-3.4A)
None
 1.06A 2qd5B-2piaA:
undetectable		 2qd5B-2piaA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 266
ARG A 238
VAL A 198
GLY A 199
 None
 0.67A 2qd5B-2pp3A:
undetectable		 2qd5B-2pp3A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ARG A  70
SER A 204
VAL A 269
GLY A 268
 None
 0.87A 2qd5B-2qo3A:
2.4		 2qd5B-2qo3A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quy PENICILLIN ACYLASE

(Lysinibacillus
sphaericus) 		PF02275
(CBAH) 		4 LEU A 252
SER A 153
VAL A  71
GLY A  70
 None
 0.97A 2qd5B-2quyA:
undetectable		 2qd5B-2quyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 116
PRO A  26
SER A  34
GLY A  22
 GOL  A1726 ( 4.8A)
None
None
None
 0.96A 2qd5B-2x40A:
undetectable		 2qd5B-2x40A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		4 LEU A 265
PRO A 192
VAL A 188
GLY A 216
 None
 0.95A 2qd5B-2yb4A:
undetectable		 2qd5B-2yb4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 MET A 206
LEU A 203
VAL A 407
GLY A 404
 None
 1.10A 2qd5B-2yquA:
2.8		 2qd5B-2yquA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE

(Nonomuraea
recticatena) 		PF00067
(p450) 		4 LEU A 285
PRO A  21
VAL A 400
GLY A 399
 None
 1.08A 2qd5B-2z36A:
undetectable		 2qd5B-2z36A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A 154
PRO A 338
GLY A 330
MET A 332
 None
 0.97A 2qd5B-3a31A:
5.4		 2qd5B-3a31A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 131
ARG A 101
VAL A  77
GLY A  76
 None
 0.92A 2qd5B-3abgA:
undetectable		 2qd5B-3abgA:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		7 MET A  99
LEU A 101
ARG A 114
PRO A 266
SER A 268
VAL A 305
GLY A 306
 CHD  A   2 (-4.0A)
CHD  A   3 ( 4.9A)
CHD  A   2 (-3.6A)
CHD  A   2 ( 4.5A)
CHD  A   2 ( 4.4A)
CHD  A   1 ( 4.9A)
CHD  A   2 ( 3.8A)
 0.80A 2qd5B-3aqiA:
53.6		 2qd5B-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 LEU A 695
PRO A 716
VAL A 624
GLY A 625
 None
 1.01A 2qd5B-3cf4A:
2.7		 2qd5B-3cf4A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		4 ARG A 339
PRO A 104
VAL A 318
GLY A 317
 None
 0.88A 2qd5B-3clqA:
undetectable		 2qd5B-3clqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpx AMINOPEPTIDASE, M42
FAMILY

(Cytophaga
hutchinsonii) 		PF05343
(Peptidase_M42) 		4 LEU A  79
PRO A  13
SER A  68
GLY A  95
 None
 1.07A 2qd5B-3cpxA:
2.4		 2qd5B-3cpxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		4 MET A 202
LEU A 198
VAL A 348
GLY A 349
 None
 0.91A 2qd5B-3dh4A:
undetectable		 2qd5B-3dh4A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ew7 LMO0794 PROTEIN

(Listeria
monocytogenes) 		PF13460
(NAD_binding_10) 		4 ARG A  11
SER A  82
VAL A 101
GLY A 102
 None
 1.11A 2qd5B-3ew7A:
3.3		 2qd5B-3ew7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfs ANTHOCYANIDIN
REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		4 MET A 198
PRO A 208
SER A 209
GLY A  19
 None
None
None
CL  A 339 ( 4.3A)
 1.09A 2qd5B-3hfsA:
2.5		 2qd5B-3hfsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ARG A  39
SER A 163
VAL A 228
GLY A 227
 None
 0.95A 2qd5B-3hhdA:
undetectable		 2qd5B-3hhdA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ARG B 197
SER B 432
VAL B 404
GLY B 405
 None
 1.10A 2qd5B-3hkzB:
undetectable		 2qd5B-3hkzB:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 185
ARG A 112
VAL A 101
GLY A 120
 None
 1.10A 2qd5B-3ip1A:
2.7		 2qd5B-3ip1A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 4 MET B 282
ARG B 348
GLY B 374
MET B 377
 None
CO3  B 491 (-3.2A)
None
None
 1.10A 2qd5B-3jruB:
3.9		 2qd5B-3jruB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 LEU A   4
SER A 177
VAL A 186
GLY A 185
 None
 1.06A 2qd5B-3kl9A:
2.7		 2qd5B-3kl9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Staphylococcus
aureus) 		PF00724
(Oxidored_FMN) 		4 LEU A 349
SER A  53
VAL A 323
GLY A 324
 None
 1.00A 2qd5B-3l5aA:
undetectable		 2qd5B-3l5aA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nb6 PENICILLIN-BINDING
PROTEIN 1A

(Aquifex
aeolicus) 		PF00912
(Transgly) 		4 LEU A 122
PRO A 200
VAL A 173
GLY A 172
 None
 0.91A 2qd5B-3nb6A:
undetectable		 2qd5B-3nb6A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 LEU A  53
PRO A 245
SER A 289
GLY A  40
 None
 0.94A 2qd5B-3ogrA:
undetectable		 2qd5B-3ogrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzy MOG

(Mycobacterium
avium) 		PF00994
(MoCF_biosynth) 		4 LEU A  67
SER A 102
VAL A 145
GLY A 144
 None
 1.09A 2qd5B-3pzyA:
5.7		 2qd5B-3pzyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		4 LEU A 121
SER A 386
VAL A 206
GLY A 364
 None
 0.88A 2qd5B-3rv6A:
undetectable		 2qd5B-3rv6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 MET A 299
ARG A 227
SER A 309
GLY A 275
 None
 1.07A 2qd5B-3s5sA:
3.5		 2qd5B-3s5sA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Rattus
norvegicus) 		PF05028
(PARG_cat) 		4 MET A 910
LEU A 914
ARG A 930
PRO A 440
 None
 0.90A 2qd5B-3uelA:
undetectable		 2qd5B-3uelA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		4 LEU A  82
SER A 121
VAL A 184
GLY A 144
 None
UNL  A 437 ( 4.8A)
None
BEZ  A 430 ( 3.7A)
 1.10A 2qd5B-3v7pA:
undetectable		 2qd5B-3v7pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtf UDP-GLUCOSE
6-DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 LEU A 134
ARG A  98
VAL A  85
GLY A  86
 None
 0.91A 2qd5B-3vtfA:
2.8		 2qd5B-3vtfA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		4 ARG A 882
SER A 844
VAL A 829
GLY A 830
 None
 0.96A 2qd5B-3zqjA:
undetectable		 2qd5B-3zqjA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		4 LEU A 368
SER A  17
VAL A  21
GLY A  53
 None
 1.02A 2qd5B-4arsA:
undetectable		 2qd5B-4arsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		4 LEU A 369
SER A  16
VAL A  20
GLY A  52
 None
 1.06A 2qd5B-4arvA:
undetectable		 2qd5B-4arvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1

(Methanocaldococcus
jannaschii) 		PF00999
(Na_H_Exchanger) 		4 LEU A 153
ARG A 347
SER A 331
GLY A 323
 None
 0.97A 2qd5B-4czbA:
undetectable		 2qd5B-4czbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwi ABC-TYPE
DIPEPTIDE/OLIGOPEPTI
DE/NICKEL TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00005
(ABC_tran)
PF08352
(oligo_HPY) 		4 LEU B 278
ARG B  11
PRO B 289
GLY B 284
 ATP  B 402 ( 4.9A)
None
None
None
 1.07A 2qd5B-4fwiB:
undetectable		 2qd5B-4fwiB:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h43 27.5 KDA VIRULENCE
PROTEIN

(Salmonella
enterica) 		PF03536
(VRP3) 		4 MET A  64
LEU A  78
ARG A  91
GLY A 123
 None
 1.03A 2qd5B-4h43A:
undetectable		 2qd5B-4h43A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN

(Methanoculleus
marisnigri) 		PF06550
(SPP) 		4 LEU A 292
SER A 231
VAL A 253
GLY A 254
 None
 0.84A 2qd5B-4hydA:
2.8		 2qd5B-4hydA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  44
PRO A  78
SER A  74
GLY A 270
 None
 1.02A 2qd5B-4jn7A:
undetectable		 2qd5B-4jn7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  48
PRO A  78
SER A  74
GLY A 270
 None
 0.83A 2qd5B-4jn7A:
undetectable		 2qd5B-4jn7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		4 LEU A 309
SER A 280
VAL A 231
GLY A 230
 None
 0.68A 2qd5B-4lx4A:
undetectable		 2qd5B-4lx4A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv4 SIGNAL PEPTIDASE I

(Bacillus
anthracis) 		PF00717
(Peptidase_S24) 		4 LEU A 131
ARG A 149
PRO A 138
GLY A  85
 None
 1.03A 2qd5B-4nv4A:
undetectable		 2qd5B-4nv4A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of8 IRREGULAR CHIASM
C-ROUGHEST PROTEIN

(Drosophila
melanogaster) 		PF07679
(I-set)
PF08205
(C2-set_2) 		4 LEU A  67
PRO A  34
SER A 121
GLY A 125
 None
None
None
GOL  A 302 (-3.6A)
 0.88A 2qd5B-4of8A:
undetectable		 2qd5B-4of8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 LEU A 275
PRO A  23
VAL A 392
GLY A 391
 None
 1.03A 2qd5B-4oqrA:
undetectable		 2qd5B-4oqrA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 LEU A 275
PRO A  23
VAL A 392
GLY A 391
 None
 1.00A 2qd5B-4oqsA:
undetectable		 2qd5B-4oqsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 LEU A 360
SER A 120
VAL A 524
GLY A 527
 IBP  A 601 ( 4.7A)
BOG  A 604 (-2.8A)
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
 1.04A 2qd5B-4ph9A:
undetectable		 2qd5B-4ph9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pug BOLA LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01722
(BolA) 		4 LEU A  85
PRO A 153
SER A 156
GLY A 118
 None
 1.11A 2qd5B-4pugA:
undetectable		 2qd5B-4pugA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiv BACTERIAL
MICROCOMPARTMENTS
FAMILY PROTEIN

(Aeromonas
hydrophila) 		PF00936
(BMC) 		4 PRO A  79
SER A  84
VAL A  75
GLY A   6
 None
 1.10A 2qd5B-4qivA:
undetectable		 2qd5B-4qivA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		4 LEU A 593
ARG A 604
SER A 572
VAL A 610
 None
 0.94A 2qd5B-4qmkA:
2.2		 2qd5B-4qmkA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r89 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08774
(VRR_NUC) 		4 LEU A 487
PRO A 506
VAL A 385
GLY A 388
 None
 1.01A 2qd5B-4r89A:
undetectable		 2qd5B-4r89A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		4 ARG A 635
SER A 509
VAL A 517
GLY A 625
 None
 1.00A 2qd5B-4uw2A:
undetectable		 2qd5B-4uw2A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 297
VAL A 209
GLY A 208
MET A 220
 None
 1.07A 2qd5B-4uy9A:
undetectable		 2qd5B-4uy9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66

(Homo sapiens) 		PF08007
(Cupin_4) 		4 MET A 538
LEU A 587
SER A 198
VAL A 559
 None
 0.84A 2qd5B-4y4rA:
undetectable		 2qd5B-4y4rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 LEU A 244
ARG A 313
SER A 160
GLY A 215
 None
SO4  A 402 ( 3.8A)
None
None
 1.07A 2qd5B-4yu9A:
undetectable		 2qd5B-4yu9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp)
PF01740
(STAS) 		4 MET A  85
LEU A 234
VAL A  52
GLY A  53
 None
 0.99A 2qd5B-5da0A:
undetectable		 2qd5B-5da0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus) 		PF02016
(Peptidase_S66) 		4 MET A 113
ARG A 158
VAL A 342
GLY A 341
 None
 1.10A 2qd5B-5f1yA:
2.3		 2qd5B-5f1yA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		4 MET A 339
PRO A 740
SER A 332
GLY A 364
 None
 1.05A 2qd5B-5fbuA:
undetectable		 2qd5B-5fbuA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 LEU A 341
PRO A 410
SER A 411
GLY A 237
 None
 1.10A 2qd5B-5fv4A:
3.1		 2qd5B-5fv4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5u BETA-HEXOSAMINIDASE

(Pseudomonas
aeruginosa) 		PF00933
(Glyco_hydro_3) 		4 MET A   1
LEU A 291
PRO A 296
GLY A 272
 None
 1.11A 2qd5B-5g5uA:
undetectable		 2qd5B-5g5uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 272
PRO A 308
SER A 310
GLY A 282
 None
None
NAG  A 805 ( 4.8A)
SO4  A 807 (-3.9A)
 1.08A 2qd5B-5gr8A:
undetectable		 2qd5B-5gr8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		4 LEU A  42
PRO A 740
SER A 309
GLY A 723
 None
 0.92A 2qd5B-5gw7A:
undetectable		 2qd5B-5gw7A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hei NFRA2

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		4 LEU A  97
ARG A  85
VAL A 108
GLY A 109
 None
 0.75A 2qd5B-5heiA:
undetectable		 2qd5B-5heiA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkf OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00156
(Pribosyltran) 		4 ARG A  38
SER A 109
VAL A 119
GLY A  68
 PRP  A 201 (-2.4A)
None
None
None
 1.11A 2qd5B-5hkfA:
undetectable		 2qd5B-5hkfA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		4 LEU A  97
SER A 206
VAL A 102
GLY A 139
 None
 1.05A 2qd5B-5hmqA:
undetectable		 2qd5B-5hmqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iof SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp) 		4 MET A  85
LEU A 234
VAL A  52
GLY A  53
 None
 0.99A 2qd5B-5iofA:
undetectable		 2qd5B-5iofA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN

(Trichodesmium
erythraeum) 		no annotation 4 LEU A 185
SER A 132
VAL A 157
GLY A 158
 None
2PO  A 301 (-2.5A)
None
None
 0.93A 2qd5B-5jvbA:
3.8		 2qd5B-5jvbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 4 MET A 588
LEU A 594
ARG A 510
GLY A 541
 None
 0.97A 2qd5B-5m6gA:
2.3		 2qd5B-5m6gA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 LEU A 646
PRO A 544
SER A 545
GLY A 493
 None
EDO  A1804 (-4.8A)
EDO  A1804 (-3.8A)
None
 1.05A 2qd5B-5x7sA:
undetectable		 2qd5B-5x7sA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE
HOLOENZYME TEB2
SUBUNIT

(Tetrahymena
thermophila) 		no annotation 4 MET E  38
LEU E  34
ARG E 166
GLY E  62
 None
 1.07A 2qd5B-6d6vE:
undetectable		 2qd5B-6d6vE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 4 MET F 111
LEU F 149
VAL F 228
GLY F 121
 None
 0.87A 2qd5B-6g2jF:
undetectable		 2qd5B-6g2jF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h25 -

(-) 		no annotation 4 LEU A  98
PRO A 209
GLY A 219
MET A 217
 None
 1.05A 2qd5B-6h25A:
undetectable		 2qd5B-6h25A:
undetectable