SIMILAR PATTERNS OF AMINO ACIDS FOR 2QD5_A_CHDA701_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		4 LEU A 191
PRO A  11
VAL A  41
GLY A   8
 None
 0.81A 2qd5A-1a2zA:
3.3		 2qd5A-1a2zA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE

(Azotobacter
vinelandii) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 225
PRO A 121
SER A  54
GLY A 116
 None
None
FAD  A 259 (-3.8A)
None
 1.02A 2qd5A-1a8pA:
2.4		 2qd5A-1a8pA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1be4 NUCLEOSIDE
DIPHOSPHATE
TRANSFERASE

(Bos taurus) 		PF00334
(NDK) 		4 MET A  68
LEU A  64
ARG A 105
GLY A 119
 None
PCG  A 160 ( 4.6A)
PCG  A 160 ( 4.6A)
None
 0.99A 2qd5A-1be4A:
undetectable		 2qd5A-1be4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		4 LEU A 366
PRO A 328
VAL A  19
GLY A  18
 None
 0.86A 2qd5A-1dkpA:
undetectable		 2qd5A-1dkpA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		4 LEU A 366
SER A  15
VAL A  19
GLY A  51
 None
 1.06A 2qd5A-1dkpA:
undetectable		 2qd5A-1dkpA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1

(Streptomyces
coelicolor) 		PF01183
(Glyco_hydro_25) 		4 LEU A 209
PRO A 159
VAL A  96
GLY A  95
 None
 0.95A 2qd5A-1jfxA:
undetectable		 2qd5A-1jfxA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 LEU A 398
PRO A 209
VAL A 290
GLY A 291
 None
 0.98A 2qd5A-1lnsA:
1.8		 2qd5A-1lnsA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqw PEPTIDE DEFORMYLASE
PDF1

(Staphylococcus
aureus) 		PF01327
(Pep_deformylase) 		4 LEU A 105
PRO A  78
VAL A  75
GLY A  60
 None
 0.95A 2qd5A-1lqwA:
undetectable		 2qd5A-1lqwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN

(Phaseolus
vulgaris) 		PF08263
(LRRNT_2) 		4 LEU A  18
PRO A  94
VAL A 113
GLY A  91
 None
 1.04A 2qd5A-1ogqA:
undetectable		 2qd5A-1ogqA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 MET A 189
LEU A 381
SER A 216
VAL A 212
 None
None
MGD  A1804 (-2.3A)
None
 0.99A 2qd5A-1ogyA:
1.7		 2qd5A-1ogyA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 PRO A 115
SER A 157
VAL A  72
GLY A  75
 None
 1.00A 2qd5A-1xpgA:
undetectable		 2qd5A-1xpgA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 MET A 410
LEU A 407
SER A 415
GLY A 332
 None
 1.08A 2qd5A-1zkcA:
undetectable		 2qd5A-1zkcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7o HUNTINGTIN
INTERACTING PROTEIN
B

(Homo sapiens) 		PF08236
(SRI) 		4 LEU A  60
PRO A  36
VAL A  44
GLY A  45
 None
 1.01A 2qd5A-2a7oA:
undetectable		 2qd5A-2a7oA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aie PEPTIDE DEFORMYLASE

(Streptococcus
pneumoniae) 		PF01327
(Pep_deformylase) 		4 LEU P 123
PRO P  89
VAL P  86
GLY P  71
 None
None
None
SB9  P 501 (-4.4A)
 1.10A 2qd5A-2aieP:
undetectable		 2qd5A-2aieP:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		4 LEU A  61
PRO A  47
VAL A  50
GLY A  51
 None
 1.07A 2qd5A-2cfbA:
undetectable		 2qd5A-2cfbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 315
SER A  15
VAL A 426
GLY A 401
 ADP  A1482 (-4.9A)
None
None
ADP  A1482 ( 3.9A)
 1.11A 2qd5A-2cgjA:
undetectable		 2qd5A-2cgjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 LEU A 186
ARG A 141
PRO A 212
GLY A 178
 None
 1.08A 2qd5A-2douA:
undetectable		 2qd5A-2douA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebj PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermus
thermophilus) 		PF01470
(Peptidase_C15) 		4 LEU A 178
PRO A   9
VAL A  38
GLY A   6
 None
 0.84A 2qd5A-2ebjA:
4.8		 2qd5A-2ebjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1

(Trypanosoma
brucei) 		PF09387
(MRP) 		4 MET B 109
LEU B  88
VAL B  99
GLY B  98
 None
 1.04A 2qd5A-2gidB:
undetectable		 2qd5A-2gidB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF03054
(tRNA_Me_trans) 		4 MET A 142
LEU A 164
VAL A 347
GLY A 357
 None
 0.91A 2qd5A-2hmaA:
undetectable		 2qd5A-2hmaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 MET A 153
LEU A 157
VAL A  75
GLY A  96
 None
 1.02A 2qd5A-2hxoA:
undetectable		 2qd5A-2hxoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		4 LEU A 183
SER A 156
VAL A 359
GLY A 165
 None
 1.11A 2qd5A-2i3oA:
undetectable		 2qd5A-2i3oA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 396
SER A 380
GLY A 451
MET A 477
 None
None
TPW  A1554 (-3.4A)
None
 1.10A 2qd5A-2ji9A:
2.3		 2qd5A-2ji9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfg EH DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF12763
(EF-hand_4) 		4 PRO A 132
SER A 134
VAL A  46
GLY A  47
 None
 0.60A 2qd5A-2kfgA:
undetectable		 2qd5A-2kfgA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nck NUCLEOSIDE
DIPHOSPHATE KINASE

(Myxococcus
xanthus) 		no annotation 4 MET R  67
LEU R  63
ARG R 104
GLY R 118
 None
 1.08A 2qd5A-2nckR:
undetectable		 2qd5A-2nckR:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4q 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING 1

(Saccharomyces
cerevisiae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 LEU A 372
SER A 128
VAL A 184
GLY A 187
 None
FLC  A 502 (-2.4A)
None
None
 1.01A 2qd5A-2p4qA:
3.0		 2qd5A-2p4qA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		4 LEU A 293
ARG A 285
VAL A 451
GLY A 362
 None
 0.95A 2qd5A-2pz1A:
undetectable		 2qd5A-2pz1A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4f HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN 1

(Oryza sativa) 		PF01627
(Hpt) 		4 MET A 134
LEU A  14
VAL A  89
GLY A  90
 None
 1.03A 2qd5A-2q4fA:
undetectable		 2qd5A-2q4fA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 225
PRO A 121
SER A  54
GLY A 116
 None
None
FAD  A 400 (-3.7A)
None
 1.07A 2qd5A-2qdxA:
2.4		 2qd5A-2qdxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 804
ARG A 760
GLY A 725
MET A 689
 None
None
None
ACT  A 950 ( 4.5A)
 1.12A 2qd5A-2qo3A:
3.6		 2qd5A-2qo3A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quy PENICILLIN ACYLASE

(Lysinibacillus
sphaericus) 		PF02275
(CBAH) 		4 LEU A 252
SER A 153
VAL A  71
GLY A  70
 None
 0.94A 2qd5A-2quyA:
undetectable		 2qd5A-2quyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 LEU A 363
ARG A 350
VAL A 563
GLY A 543
 None
 0.94A 2qd5A-2qvwA:
undetectable		 2qd5A-2qvwA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2

(Homo sapiens) 		PF00709
(Adenylsucc_synt) 		4 LEU A  49
ARG A 416
VAL A 445
GLY A 446
 None
None
None
GDP  A1457 (-3.3A)
 0.85A 2qd5A-2v40A:
undetectable		 2qd5A-2v40A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 116
PRO A  26
SER A  34
GLY A  22
 GOL  A1726 ( 4.8A)
None
None
None
 1.01A 2qd5A-2x40A:
2.3		 2qd5A-2x40A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ARG A  42
PRO A 402
SER A 350
GLY A  74
 None
 0.84A 2qd5A-2xsgA:
undetectable		 2qd5A-2xsgA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 MET A 146
LEU A 203
VAL A 218
GLY A 219
 None
None
NAP  A 701 (-4.3A)
None
 1.06A 2qd5A-2y05A:
2.8		 2qd5A-2y05A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		4 LEU A 265
PRO A 192
VAL A 188
GLY A 216
 None
 0.87A 2qd5A-2yb4A:
undetectable		 2qd5A-2yb4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 147
PRO A  92
VAL A  68
GLY A  69
 None
 1.03A 2qd5A-2yw2A:
2.6		 2qd5A-2yw2A:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		6 MET A  99
LEU A 101
PRO A 266
SER A 268
VAL A 305
GLY A 306
 CHD  A   2 (-4.0A)
CHD  A   3 ( 4.9A)
CHD  A   2 ( 4.5A)
CHD  A   2 ( 4.4A)
CHD  A   1 ( 4.9A)
CHD  A   2 ( 3.8A)
 0.74A 2qd5A-3aqiA:
53.6		 2qd5A-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0j DNA POLYMERASE
SUBUNIT DELTA-2
DNA POLYMERASE
SUBUNIT DELTA-3

(Homo sapiens;
Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF09507
(CDC27) 		4 LEU A 439
ARG A  26
SER B  97
GLY A 224
 None
 0.88A 2qd5A-3e0jA:
undetectable		 2qd5A-3e0jA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
pseudomallei) 		PF02548
(Pantoate_transf) 		4 LEU A  20
VAL A 219
GLY A 218
MET A 232
 None
 1.12A 2qd5A-3ez4A:
undetectable		 2qd5A-3ez4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		4 PRO A 406
SER A 408
VAL A  40
GLY A 262
 None
 0.97A 2qd5A-3i4jA:
undetectable		 2qd5A-3i4jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 MET A  95
LEU A  73
VAL A  83
GLY A  12
 None
 1.11A 2qd5A-3k96A:
2.4		 2qd5A-3k96A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 LEU A   4
SER A 177
VAL A 186
GLY A 185
 None
 1.07A 2qd5A-3kl9A:
3.0		 2qd5A-3kl9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 392
PRO A 196
VAL A 430
GLY A 429
 None
 0.98A 2qd5A-3krtA:
undetectable		 2qd5A-3krtA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfw FLAVIN
REDUCTASE-LIKE,
FMN-BINDING PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF01613
(Flavin_Reduct) 		4 LEU A 105
PRO A  49
VAL A  51
GLY A 135
 None
 1.11A 2qd5A-3nfwA:
undetectable		 2qd5A-3nfwA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 LEU A  53
PRO A 245
SER A 289
GLY A  40
 None
 0.91A 2qd5A-3ogrA:
undetectable		 2qd5A-3ogrA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		PF04095
(NAPRTase) 		4 LEU A 353
ARG A 136
VAL A  49
GLY A  48
 None
 1.05A 2qd5A-3os4A:
undetectable		 2qd5A-3os4A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 LEU A 320
ARG A 414
PRO A  68
SER A  90
 None
 1.13A 2qd5A-3p1vA:
4.0		 2qd5A-3p1vA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pn1 DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		4 LEU A 125
PRO A 165
VAL A 234
GLY A 233
 None
 1.01A 2qd5A-3pn1A:
undetectable		 2qd5A-3pn1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzy MOG

(Mycobacterium
avium) 		PF00994
(MoCF_biosynth) 		4 LEU A  67
SER A 102
VAL A 145
GLY A 144
 None
 1.08A 2qd5A-3pzyA:
5.7		 2qd5A-3pzyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		4 LEU A 121
SER A 386
VAL A 206
GLY A 364
 None
 0.86A 2qd5A-3rv6A:
undetectable		 2qd5A-3rv6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 LEU A1066
ARG A1052
SER A1036
GLY A1056
 None
 0.91A 2qd5A-3rzeA:
undetectable		 2qd5A-3rzeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 LEU A 557
SER A 137
VAL A 249
GLY A 248
 None
 1.07A 2qd5A-3u1kA:
undetectable		 2qd5A-3u1kA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		4 LEU A  82
SER A 121
VAL A 184
GLY A 144
 None
UNL  A 437 ( 4.8A)
None
BEZ  A 430 ( 3.7A)
 1.05A 2qd5A-3v7pA:
undetectable		 2qd5A-3v7pA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 LEU A  55
SER A 103
VAL A 195
GLY A 196
 None
LLP  A  61 ( 3.9A)
None
None
 1.11A 2qd5A-3vabA:
2.8		 2qd5A-3vabA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 LEU A 300
SER A  53
VAL A 269
GLY A 270
 None
 1.08A 2qd5A-3wy2A:
undetectable		 2qd5A-3wy2A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		4 LEU A 483
PRO A 511
SER A 524
GLY A 389
 None
 1.09A 2qd5A-4aahA:
undetectable		 2qd5A-4aahA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		4 LEU A 368
PRO A 331
VAL A  21
GLY A  20
 None
 0.83A 2qd5A-4arsA:
undetectable		 2qd5A-4arsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		4 LEU A 368
SER A  17
VAL A  21
GLY A  53
 None
 1.00A 2qd5A-4arsA:
undetectable		 2qd5A-4arsA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		4 LEU A 369
PRO A 331
VAL A  20
GLY A  19
 None
 0.87A 2qd5A-4arvA:
undetectable		 2qd5A-4arvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		4 LEU A 369
SER A  16
VAL A  20
GLY A  52
 None
 1.02A 2qd5A-4arvA:
undetectable		 2qd5A-4arvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4d FERREDOXIN-NADP
REDUCTASE

(Xanthomonas
citri) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 226
PRO A 122
SER A  55
GLY A 117
 None
None
FAD  A1260 (-3.8A)
None
 1.09A 2qd5A-4b4dA:
2.4		 2qd5A-4b4dA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		4 PRO A 509
SER A 471
VAL A 504
GLY A 512
 None
None
SLA  A 801 (-4.2A)
None
 1.10A 2qd5A-4fwgA:
undetectable		 2qd5A-4fwgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica) 		PF04261
(Dyp_perox) 		4 MET A 183
ARG A 353
VAL A  84
GLY A 187
 None
 0.82A 2qd5A-4gs1A:
undetectable		 2qd5A-4gs1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN

(Methanoculleus
marisnigri) 		PF06550
(SPP) 		4 LEU A 292
SER A 231
VAL A 253
GLY A 254
 None
 0.86A 2qd5A-4hydA:
2.6		 2qd5A-4hydA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  44
PRO A  78
SER A  74
GLY A 270
 None
 1.03A 2qd5A-4jn7A:
undetectable		 2qd5A-4jn7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  48
PRO A  78
SER A  74
GLY A 270
 None
 0.88A 2qd5A-4jn7A:
undetectable		 2qd5A-4jn7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		4 LEU A 309
SER A 280
VAL A 231
GLY A 230
 None
 0.72A 2qd5A-4lx4A:
1.7		 2qd5A-4lx4A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 LEU A 217
ARG A 242
VAL A 188
GLY A 122
 None
 0.83A 2qd5A-4m9xA:
2.9		 2qd5A-4m9xA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6r VELB

(Aspergillus
nidulans) 		PF11754
(Velvet) 		4 LEU B  91
PRO B 304
VAL B 282
GLY B 283
 None
 1.12A 2qd5A-4n6rB:
undetectable		 2qd5A-4n6rB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of8 IRREGULAR CHIASM
C-ROUGHEST PROTEIN

(Drosophila
melanogaster) 		PF07679
(I-set)
PF08205
(C2-set_2) 		4 LEU A  67
PRO A  34
SER A 121
GLY A 125
 None
None
None
GOL  A 302 (-3.6A)
 0.99A 2qd5A-4of8A:
undetectable		 2qd5A-4of8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 LEU A 275
PRO A  23
VAL A 392
GLY A 391
 None
 1.00A 2qd5A-4oqrA:
undetectable		 2qd5A-4oqrA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 LEU A 275
PRO A  23
VAL A 392
GLY A 391
 None
 0.99A 2qd5A-4oqsA:
undetectable		 2qd5A-4oqsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovt TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		4 PRO A 107
VAL A 103
GLY A 102
MET A 175
 None
 1.01A 2qd5A-4ovtA:
undetectable		 2qd5A-4ovtA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 978
PRO A 433
SER A 436
GLY A 983
 None
 0.86A 2qd5A-4ptfA:
undetectable		 2qd5A-4ptfA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE

(Brucella
abortus) 		PF01041
(DegT_DnrJ_EryC1) 		4 MET A   1
LEU A 354
VAL A 365
GLY A 364
 None
 0.82A 2qd5A-4qgrA:
undetectable		 2qd5A-4qgrA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r89 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08774
(VRR_NUC) 		4 LEU A 487
PRO A 506
VAL A 385
GLY A 388
 None
 0.94A 2qd5A-4r89A:
undetectable		 2qd5A-4r89A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		4 LEU A 115
PRO A 247
VAL A 294
GLY A 293
 ACT  A1334 (-4.1A)
None
None
None
 1.11A 2qd5A-4uobA:
undetectable		 2qd5A-4uobA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 297
VAL A 209
GLY A 208
MET A 220
 None
 1.10A 2qd5A-4uy9A:
undetectable		 2qd5A-4uy9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP

(Pseudomonas
putida) 		PF03480
(DctP) 		4 MET A 180
LEU A 163
PRO A 106
GLY A 230
 None
 0.79A 2qd5A-4xfeA:
undetectable		 2qd5A-4xfeA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66

(Homo sapiens) 		PF08007
(Cupin_4) 		4 MET A 538
LEU A 587
SER A 198
VAL A 559
 None
 0.86A 2qd5A-4y4rA:
undetectable		 2qd5A-4y4rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 MET A 835
LEU A 828
ARG A 802
SER A 572
 None
 0.95A 2qd5A-4yooA:
undetectable		 2qd5A-4yooA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		4 LEU A 171
PRO A  20
VAL A 111
GLY A 112
 None
None
SAH  A 301 (-4.1A)
SAH  A 301 ( 4.7A)
 1.05A 2qd5A-5bp7A:
undetectable		 2qd5A-5bp7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp)
PF01740
(STAS) 		4 MET A  85
LEU A 234
VAL A  52
GLY A  53
 None
 1.06A 2qd5A-5da0A:
undetectable		 2qd5A-5da0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		4 MET A1333
LEU A1329
PRO A1367
GLY A1370
 None
 0.98A 2qd5A-5deuA:
undetectable		 2qd5A-5deuA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1r 7S VICILIN

(Carya
illinoinensis) 		PF00190
(Cupin_1) 		4 LEU A 584
ARG A 724
VAL A 637
GLY A 716
 None
MPD  A 802 (-4.5A)
MPD  A 802 (-4.9A)
None
 1.04A 2qd5A-5e1rA:
undetectable		 2qd5A-5e1rA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exp TRANSCRIPTIONAL
REGULATOR FLEQ

(Pseudomonas
aeruginosa) 		PF00158
(Sigma54_activat) 		4 LEU A 328
PRO A 387
VAL A 383
GLY A 382
 None
 0.97A 2qd5A-5expA:
2.3		 2qd5A-5expA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		4 MET A 339
PRO A 740
SER A 332
GLY A 364
 None
 1.10A 2qd5A-5fbuA:
undetectable		 2qd5A-5fbuA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		4 MET A 146
ARG A 316
VAL A  43
GLY A 150
 None
 0.87A 2qd5A-5fw4A:
undetectable		 2qd5A-5fw4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		4 LEU A 111
ARG A 242
PRO A 219
SER A 255
 None
 1.11A 2qd5A-5g4iA:
undetectable		 2qd5A-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		4 LEU A  97
SER A 206
VAL A 102
GLY A 139
 None
 1.07A 2qd5A-5hmqA:
2.8		 2qd5A-5hmqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iof SULPHATE TRANSPORTER

(Deinococcus
geothermalis) 		PF00916
(Sulfate_transp) 		4 MET A  85
LEU A 234
VAL A  52
GLY A  53
 None
 1.06A 2qd5A-5iofA:
undetectable		 2qd5A-5iofA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 220
SER A 240
VAL A 259
GLY A 236
 None
 1.11A 2qd5A-5kiaA:
3.4		 2qd5A-5kiaA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE

(Schistosoma
mansoni) 		PF00334
(NDK) 		4 MET A  65
LEU A  61
ARG A 102
GLY A 116
 None
ADP  A 201 (-4.0A)
ADP  A 201 (-3.4A)
None
 1.08A 2qd5A-5kk8A:
undetectable		 2qd5A-5kk8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot4 INTERAPTIN

(Legionella
pneumophila) 		no annotation 4 PRO A  48
SER A  49
VAL A 181
GLY A 180
 None
 0.96A 2qd5A-5ot4A:
undetectable		 2qd5A-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thx FERREDOXIN--NADP
REDUCTASE

(Neisseria
gonorrhoeae) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 225
PRO A 121
SER A  54
GLY A 116
 None
None
FAD  A 303 (-3.8A)
NAP  A 301 ( 3.9A)
 1.11A 2qd5A-5thxA:
2.4		 2qd5A-5thxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6d NUCLEOSIDE
DIPHOSPHATE KINASE

(Neisseria
gonorrhoeae) 		PF00334
(NDK) 		4 MET A  67
LEU A  63
ARG A 104
GLY A 118
 None
CIT  A 201 ( 4.7A)
CIT  A 201 (-2.9A)
None
 1.11A 2qd5A-5v6dA:
undetectable		 2qd5A-5v6dA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 LEU A 646
PRO A 544
SER A 545
GLY A 493
 None
EDO  A1804 (-4.8A)
EDO  A1804 (-3.8A)
None
 1.11A 2qd5A-5x7sA:
undetectable		 2qd5A-5x7sA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 4 MET F 111
LEU F 149
VAL F 228
GLY F 121
 None
 0.88A 2qd5A-6g2jF:
undetectable		 2qd5A-6g2jF:
undetectable