SIMILAR PATTERNS OF AMINO ACIDS FOR 2QD4_B_CHDB928_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cau CANAVALIN

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		5 LEU B 356
PHE B 294
LEU B 362
MET B 288
ARG B 376
 None
 1.15A 2qd4B-1cauB:
undetectable		 2qd4B-1cauB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 LEU A 488
GLN A 478
LEU A 496
VAL A 440
VAL A 387
 None
 1.35A 2qd4B-1d4eA:
undetectable		 2qd4B-1d4eA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 LEU A 164
LEU A  85
LEU A 151
PRO A 150
VAL A 121
 None
 1.31A 2qd4B-1gz0A:
3.8		 2qd4B-1gz0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9m MOLYBDENUM-BINDING-P
ROTEIN

(Azotobacter
vinelandii) 		PF03459
(TOBE) 		5 LEU A  81
LEU A  29
LEU A 138
VAL A  55
VAL A  59
 None
 1.22A 2qd4B-1h9mA:
undetectable		 2qd4B-1h9mA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU X  17
PHE X  21
LEU X 155
PRO X 167
VAL X 169
 None
 1.38A 2qd4B-1js1X:
2.9		 2qd4B-1js1X:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		10 LEU A  62
PHE A  63
ARG A  87
GLN A  94
HIS A 235
LEU A 237
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 0.63A 2qd4B-1lbqA:
48.3		 2qd4B-1lbqA:
49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		7 PHE A  63
LEU A  68
ARG A  87
HIS A 235
LEU A 237
VAL A 277
TRP A 282
 None
 1.12A 2qd4B-1lbqA:
48.3		 2qd4B-1lbqA:
49.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvh CRYPTIC LOCI
REGULATOR 4

(Schizosaccharomyces
pombe) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 LEU A 433
PHE A 383
LEU A 385
LEU A 245
VAL A 249
 None
 1.32A 2qd4B-1mvhA:
undetectable		 2qd4B-1mvhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 256
PHE A 259
LEU A  98
PRO A  99
VAL A 185
 None
 1.20A 2qd4B-1odfA:
undetectable		 2qd4B-1odfA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 LEU A 569
PHE A 570
GLN A 453
LEU A 401
PRO A 402
 None
 1.22A 2qd4B-1ogyA:
undetectable		 2qd4B-1ogyA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s28 ORF1

(Pseudomonas
savastanoi) 		PF05932
(CesT) 		5 LEU A  10
PHE A   7
LEU A  14
LEU A 119
VAL A  40
 None
 1.23A 2qd4B-1s28A:
undetectable		 2qd4B-1s28A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		5 LEU A 149
LEU A 153
LEU A 412
PRO A 413
VAL A 330
 None
 1.22A 2qd4B-1sqgA:
2.5		 2qd4B-1sqgA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 LEU A 433
LEU A 404
MET A 405
LEU A 309
VAL A 411
 None
 1.29A 2qd4B-1xa6A:
undetectable		 2qd4B-1xa6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A  39
PHE A  67
LEU A  52
LEU A  29
VAL A  34
 None
 1.28A 2qd4B-1yrgA:
undetectable		 2qd4B-1yrgA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU A 109
ARG A  11
LEU A  93
PRO A  68
VAL A  70
 None
 1.30A 2qd4B-1yrvA:
undetectable		 2qd4B-1yrvA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		5 LEU A 319
LEU A 323
ARG A 370
LEU A 285
PRO A 349
 None
 1.10A 2qd4B-2aynA:
undetectable		 2qd4B-2aynA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 LEU A 528
LEU A 531
LEU A 569
VAL A 443
VAL A 578
 None
 1.39A 2qd4B-2d3iA:
undetectable		 2qd4B-2d3iA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 1.09A 2qd4B-2dc0A:
undetectable		 2qd4B-2dc0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 240
PHE A 244
LEU A 432
GLN A 261
LEU A 435
 None
 1.17A 2qd4B-2g39A:
undetectable		 2qd4B-2g39A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 LEU A 311
LEU A 541
MET A 100
LEU A 603
VAL A  92
 None
 1.26A 2qd4B-2inyA:
undetectable		 2qd4B-2inyA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 LEU A   7
PHE A  58
LEU A   5
LEU A 125
VAL A 128
 None
 1.30A 2qd4B-2jgvA:
2.6		 2qd4B-2jgvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00531
(Death) 		5 LEU H 799
LEU H 836
GLN H 863
LEU H 779
VAL H 869
 None
 1.37A 2qd4B-2of5H:
undetectable		 2qd4B-2of5H:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onk MOLYBDATE/TUNGSTATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Archaeoglobus
fulgidus) 		PF00005
(ABC_tran) 		5 LEU A 147
LEU A   3
MET A  22
VAL A  18
VAL A 183
 None
 1.28A 2qd4B-2onkA:
undetectable		 2qd4B-2onkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2

(Homo sapiens) 		PF00293
(NUDIX) 		5 LEU A 116
LEU A  66
ARG A 111
GLN A  13
LEU A 197
 None
None
POP  A 230 (-3.8A)
None
None
 1.29A 2qd4B-2pnyA:
undetectable		 2qd4B-2pnyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		5 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.36A 2qd4B-2x66A:
undetectable		 2qd4B-2x66A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.91A 2qd4B-2z63A:
undetectable		 2qd4B-2z63A:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		11 LEU A  92
PHE A  93
LEU A  98
MET A  99
GLN A 122
HIS A 263
LEU A 265
PRO A 266
VAL A 269
VAL A 305
TRP A 310
 CHD  A   1 (-4.8A)
CHD  A   1 ( 4.7A)
CHD  A   1 (-4.3A)
CHD  A   2 (-4.0A)
CHD  A   1 ( 4.1A)
CHD  A   1 (-4.3A)
None
CHD  A   2 ( 4.5A)
None
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
 0.41A 2qd4B-3aqiA:
60.6		 2qd4B-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 LEU A  94
GLN A 286
LEU A 179
PRO A 181
VAL A 208
 None
 1.27A 2qd4B-3b4wA:
2.0		 2qd4B-3b4wA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt7 TRNA
(URACIL-5-)-METHYLTR
ANSFERASE

(Escherichia
coli) 		PF05958
(tRNA_U5-meth_tr) 		5 LEU A 214
ARG A 318
LEU A 200
VAL A 174
VAL A 206
 None
 1.35A 2qd4B-3bt7A:
undetectable		 2qd4B-3bt7A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt7 TRNA
(URACIL-5-)-METHYLTR
ANSFERASE

(Escherichia
coli) 		PF05958
(tRNA_U5-meth_tr) 		5 LEU A 214
PHE A 232
ARG A 318
VAL A 174
VAL A 206
 None
 1.38A 2qd4B-3bt7A:
undetectable		 2qd4B-3bt7A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695

(Pyrococcus
furiosus) 		PF01814
(Hemerythrin)
PF13596
(PAS_10) 		5 LEU A 125
LEU A 262
LEU A 317
PRO A 318
VAL A 321
 None
 1.28A 2qd4B-3caxA:
undetectable		 2qd4B-3caxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 199
LEU A 196
GLN A 205
LEU A  10
VAL A 108
 None
 1.07A 2qd4B-3dj4A:
2.6		 2qd4B-3dj4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.81A 2qd4B-3fxiA:
undetectable		 2qd4B-3fxiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		5 LEU A 179
LEU A  72
LEU A 118
VAL A 114
VAL A 126
 None
 1.33A 2qd4B-3gonA:
undetectable		 2qd4B-3gonA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU B 801
LEU B 527
GLN B1082
PRO B 510
VAL B 508
 None
 1.22A 2qd4B-3h0gB:
undetectable		 2qd4B-3h0gB:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		5 LEU A  94
GLN A 287
LEU A 179
PRO A 181
VAL A 208
 None
 1.38A 2qd4B-3k2wA:
undetectable		 2qd4B-3k2wA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnp AMIDOHYDROLASE
FAMILY PROTEIN
OLEI01672_1_465

(Oleispira
antarctica) 		PF01979
(Amidohydro_1) 		5 PHE A 249
LEU A 106
MET A 107
HIS A 216
VAL A 114
 None
 1.32A 2qd4B-3lnpA:
undetectable		 2qd4B-3lnpA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.16A 2qd4B-3m1mA:
undetectable		 2qd4B-3m1mA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		5 LEU A 271
LEU A 269
ARG A 318
PRO A 373
VAL A 258
 None
 1.20A 2qd4B-3pjxA:
undetectable		 2qd4B-3pjxA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A 267
LEU A 263
LEU A 211
VAL A 237
VAL A  45
 None
 1.09A 2qd4B-3pkjA:
undetectable		 2qd4B-3pkjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uat DISKS LARGE HOMOLOG
1

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 LEU A 588
PHE A 608
GLN A 826
LEU A 583
VAL A 614
 None
 1.02A 2qd4B-3uatA:
undetectable		 2qd4B-3uatA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 376
LEU A 519
GLN A 337
LEU A 529
VAL A 532
 None
 1.19A 2qd4B-3v4oA:
3.1		 2qd4B-3v4oA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
LEU A 369
VAL A 380
VAL A 458
 None
 0.97A 2qd4B-3v4oA:
3.1		 2qd4B-3v4oA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		5 LEU A   3
PHE A   5
LEU A 108
LEU A 158
VAL A 122
 None
 1.39A 2qd4B-3w3sA:
undetectable		 2qd4B-3w3sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 LEU A 143
PHE A 146
LEU A 124
LEU A 203
VAL A 221
 IPA  A 401 (-4.8A)
None
None
None
None
 1.34A 2qd4B-3wafA:
undetectable		 2qd4B-3wafA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 518
LEU A 496
GLN A 508
LEU A 421
VAL A 419
 None
 1.39A 2qd4B-3wpeA:
undetectable		 2qd4B-3wpeA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A 267
LEU A 263
LEU A 211
VAL A 237
VAL A  45
 None
 1.04A 2qd4B-3zg6A:
undetectable		 2qd4B-3zg6A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 LEU A  53
PHE A  54
LEU A 364
VAL A  27
VAL A 436
 None
 1.37A 2qd4B-3zvtA:
undetectable		 2qd4B-3zvtA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csw CUPIN 4 FAMILY
PROTEIN

(Rhodothermus
marinus) 		PF08007
(Cupin_4) 		5 LEU A  89
PHE A  79
LEU A  44
VAL A  98
VAL A  53
 None
 1.28A 2qd4B-4cswA:
undetectable		 2qd4B-4cswA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6y CITRATE SYNTHASE

(Vibrio
vulnificus) 		PF00285
(Citrate_synt) 		5 PHE A 198
MET A 220
GLN A 183
LEU A 330
VAL A 326
 None
 1.15A 2qd4B-4e6yA:
undetectable		 2qd4B-4e6yA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 LEU A  41
LEU A  55
GLN A 142
LEU A 104
VAL A 100
 None
 1.38A 2qd4B-4egeA:
undetectable		 2qd4B-4egeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hs4 CHROMATE REDUCTASE

(Komagataeibacter
hansenii) 		PF03358
(FMN_red) 		5 LEU A 138
PHE A 137
GLN A  56
LEU A  92
VAL A  88
 None
 1.34A 2qd4B-4hs4A:
4.4		 2qd4B-4hs4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
LEU A 369
VAL A 380
VAL A 458
 None
 0.87A 2qd4B-4i1pA:
2.2		 2qd4B-4i1pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 136
LEU A 280
HIS A 178
LEU A 182
VAL A 186
 None
 0.94A 2qd4B-4idaA:
2.8		 2qd4B-4idaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7

(Homo sapiens) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 LEU A  95
LEU A 119
LEU A 167
PRO A 168
VAL A 185
 None
 1.06A 2qd4B-4irqA:
1.9		 2qd4B-4irqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites virus) 		PF01768
(Birna_VP4) 		5 ARG A 515
LEU A 560
PRO A 544
VAL A 653
VAL A 546
 None
 1.23A 2qd4B-4izkA:
undetectable		 2qd4B-4izkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlz UNCHARACTERIZED
PROTEIN

(Sus scrofa) 		PF03281
(Mab-21) 		5 LEU A 354
PHE A 356
LEU A 336
GLN A 312
VAL A 209
 None
 1.24A 2qd4B-4jlzA:
undetectable		 2qd4B-4jlzA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmd PUTATIVE
UNCHARACTERIZED
PROTEIN MPPR

(Streptomyces
hygroscopicus) 		PF06314
(ADC) 		5 LEU A 122
LEU A 215
GLN A 163
LEU A 285
VAL A 240
 None
 1.34A 2qd4B-4jmdA:
undetectable		 2qd4B-4jmdA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k82 LV-RANASPUMIN
(LV-RSN-1)

(Leptodactylus
vastus) 		no annotation 5 LEU A 198
PHE A 191
LEU A 201
LEU A 138
VAL A 145
 None
 1.04A 2qd4B-4k82A:
undetectable		 2qd4B-4k82A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mla CYTOKININ OXIDASE 2

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 LEU A 404
PHE A 271
LEU A 433
ARG A 353
GLN A 176
 IPA  A 610 (-4.8A)
None
None
None
None
 1.35A 2qd4B-4mlaA:
undetectable		 2qd4B-4mlaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Escherichia
fergusonii) 		PF03480
(DctP) 		5 PHE A 121
GLN A 133
LEU A 311
PRO A 308
VAL A 307
 None
None
IOD  A 436 ( 4.4A)
None
None
 1.23A 2qd4B-4p1eA:
undetectable		 2qd4B-4p1eA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 LEU A 310
PHE A 275
LEU A 338
LEU A 370
VAL A 315
 None
 1.39A 2qd4B-4perA:
undetectable		 2qd4B-4perA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A2961
LEU A2715
LEU A2972
VAL A2800
VAL A2841
 None
 1.36A 2qd4B-4qyrA:
2.5		 2qd4B-4qyrA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		5 LEU A 217
PHE A 218
LEU A 230
ARG A 268
LEU A 280
 None
 1.37A 2qd4B-4r9oA:
undetectable		 2qd4B-4r9oA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU A 371
LEU A 392
MET A 389
VAL A 381
TRP A 410
 None
 1.24A 2qd4B-4u7lA:
undetectable		 2qd4B-4u7lA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		5 PHE A 471
GLN A 582
LEU A 516
PRO A 526
VAL A 524
 None
 1.14A 2qd4B-4uj6A:
undetectable		 2qd4B-4uj6A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND
PATE

(Lyngbya
aestuarii;
uncultured
Prochloron sp.) 		PF02624
(YcaO)
no annotation 		5 LEU A  25
PHE A  13
LEU A  43
LEU C  29
VAL A  71
 None
 1.36A 2qd4B-4v1uA:
3.6		 2qd4B-4v1uA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 LEU A 359
PHE A 309
LEU A 396
VAL A 367
VAL A 420
 None
None
EDO  A 706 (-4.1A)
None
None
 1.23A 2qd4B-4wd1A:
4.1		 2qd4B-4wd1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 388
LEU A 379
PRO A 401
VAL A 381
VAL A 141
 None
 1.29A 2qd4B-4wpzA:
undetectable		 2qd4B-4wpzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Burkholderia
thailandensis) 		PF01128
(IspD) 		5 LEU A 176
PHE A 171
LEU A  90
PRO A  10
VAL A  54
 None
 1.32A 2qd4B-4ys8A:
2.6		 2qd4B-4ys8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		5 LEU A 144
LEU A 183
PRO A 276
VAL A 277
VAL A  38
 None
 1.27A 2qd4B-4zrqA:
undetectable		 2qd4B-4zrqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		5 PHE K 678
ARG K  60
HIS K 666
LEU K 667
VAL K 620
 None
 1.27A 2qd4B-5anbK:
2.6		 2qd4B-5anbK:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		5 LEU A 343
LEU A 262
LEU A 277
VAL A 275
VAL A 305
 None
 1.28A 2qd4B-5cdhA:
undetectable		 2qd4B-5cdhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddv 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		5 LEU A 169
PHE A 164
LEU A  91
PRO A   8
VAL A  52
 None
 1.16A 2qd4B-5ddvA:
2.5		 2qd4B-5ddvA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Hirschia
baltica) 		PF00160
(Pro_isomerase) 		5 LEU A 211
GLN A 256
VAL A  52
VAL A 154
TRP A 186
 None
 1.30A 2qd4B-5ex2A:
undetectable		 2qd4B-5ex2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A  47
PHE A 541
GLN A  95
PRO A  64
VAL A 271
 None
 1.38A 2qd4B-5fkuA:
undetectable		 2qd4B-5fkuA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1

(Homo sapiens) 		no annotation 5 LEU A  81
LEU A  85
HIS A  42
LEU A  10
VAL A  64
 MLY  A  78 ( 4.3A)
None
None
None
None
 1.16A 2qd4B-5forA:
3.6		 2qd4B-5forA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		5 LEU A  77
PHE A 170
LEU A  76
ARG A 176
LEU A 274
 None
 1.33A 2qd4B-5gkvA:
undetectable		 2qd4B-5gkvA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.22A 2qd4B-5gslA:
undetectable		 2qd4B-5gslA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL

(Caenorhabditis
elegans) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF16526
(CLZ) 		5 LEU A 509
PHE A 588
LEU A 590
LEU A 609
VAL A 491
 None
 1.23A 2qd4B-5h3oA:
undetectable		 2qd4B-5h3oA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		5 LEU A 397
LEU A 400
GLN A 454
LEU A  16
VAL A 129
 None
FAD  A 601 (-4.6A)
None
None
None
 1.21A 2qd4B-5j7xA:
undetectable		 2qd4B-5j7xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 LEU A  87
GLN A 283
LEU A 176
PRO A 178
VAL A 205
 None
 1.35A 2qd4B-5jryA:
undetectable		 2qd4B-5jryA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdm MAJOR TEGUMENT
PROTEIN

(Human
gammaherpesvirus
4) 		PF12818
(Tegument_dsDNA) 		5 LEU D 468
LEU D 471
LEU D 455
VAL D 451
VAL D 576
 None
 1.32A 2qd4B-5kdmD:
undetectable		 2qd4B-5kdmD:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens;
Homo sapiens) 		no annotation
PF04858
(TH1) 		5 LEU B 239
LEU A  61
LEU A  75
PRO A 101
VAL A  68
 None
 1.26A 2qd4B-5l3xB:
undetectable		 2qd4B-5l3xB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjr PROTEIN THF1

(Thermosynechococcus
elongatus) 		PF11264
(ThylakoidFormat) 		5 LEU A  40
HIS A 127
LEU A 167
PRO A 168
VAL A 172
 None
 1.23A 2qd4B-5mjrA:
undetectable		 2qd4B-5mjrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Sulfolobus
solfataricus) 		no annotation 5 LEU A  35
ARG A  69
LEU A   4
VAL A 231
VAL A  74
 None
 1.27A 2qd4B-5n2pA:
undetectable		 2qd4B-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nji PHTHIOCEROL/PHENOLPH
THIOCEROL SYNTHESIS
POLYKETIDE SYNTHASE
TYPE I PPSC

(Mycobacterium
tuberculosis) 		PF14765
(PS-DH) 		5 LEU A 949
LEU A 956
HIS A 928
PRO A1125
VAL A1126
 None
 1.25A 2qd4B-5njiA:
undetectable		 2qd4B-5njiA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8j CYCLIC GMP-AMP
SYNTHASE

(Homo sapiens) 		PF03281
(Mab-21) 		5 LEU A 377
PHE A 379
LEU A 359
ARG A 353
VAL A 234
 None
 1.31A 2qd4B-5v8jA:
undetectable		 2qd4B-5v8jA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vh6 ELONGATION FACTOR G

(Bacillus
subtilis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 LEU A  96
LEU A  99
LEU A 278
PRO A 279
VAL A 251
 None
 1.35A 2qd4B-5vh6A:
3.7		 2qd4B-5vh6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.19A 2qd4B-5vl1A:
undetectable		 2qd4B-5vl1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa) 		no annotation 5 LEU X 196
LEU X 146
LEU X 115
VAL X 126
VAL X 208
 None
 1.35A 2qd4B-5vtmX:
undetectable		 2qd4B-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 590
PHE A 591
LEU A 410
PRO A 549
VAL A 398
 None
 1.11A 2qd4B-5xxoA:
3.3		 2qd4B-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 5 LEU A 134
PRO A 135
VAL A 138
VAL A  87
TRP A 214
 None
 1.23A 2qd4B-5y4gA:
undetectable		 2qd4B-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.23A 2qd4B-5yxgA:
undetectable		 2qd4B-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.25A 2qd4B-5z24A:
undetectable		 2qd4B-5z24A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 LEU A 521
LEU A 499
GLN A 511
LEU A 422
VAL A 420
 None
 1.26A 2qd4B-5zlnA:
undetectable		 2qd4B-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 LEU A 698
PHE A 721
LEU A 728
VAL A 755
VAL A 709
 None
 1.27A 2qd4B-5zlnA:
undetectable		 2qd4B-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqh LYSINE--TRNA LIGASE

(Mycolicibacterium
thermoresistibile) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 193
PHE A 198
LEU A 292
LEU A 413
TRP A 411
 None
 1.27A 2qd4B-6aqhA:
undetectable		 2qd4B-6aqhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 5 LEU A  96
LEU A  99
LEU A 278
PRO A 279
VAL A 251
 None
 1.35A 2qd4B-6bk7A:
2.7		 2qd4B-6bk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 GLN A 141
LEU A  78
PRO A 117
VAL A 119
TRP A 115
 None
 1.17A 2qd4B-6evgA:
undetectable		 2qd4B-6evgA:
undetectable