SIMILAR PATTERNS OF AMINO ACIDS FOR 2QD4_A_CHDA803

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5i PLASMINOGEN
ACTIVATOR


(Desmodus
rotundus)
PF00089
(Trypsin)
4 LEU A 123
PRO A 124
LEU A 235
ILE A 238
None
0.76A 2qd4A-1a5iA:
undetectable
2qd4A-1a5iA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 LEU A 328
PRO A 330
LEU A 331
ILE A 386
ARG A 387
None
1.21A 2qd4A-1d2fA:
3.2
2qd4A-1d2fA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba)
PF00232
(Glyco_hydro_1)
4 LEU M 144
PRO M 145
LEU M 148
ILE M 160
None
0.78A 2qd4A-1dwaM:
undetectable
2qd4A-1dwaM:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 NATURAL KILLER CELL
PROTEASE 1


(Rattus
norvegicus)
PF00089
(Trypsin)
4 LEU A 123
PRO A 124
LEU A 235
ILE A 238
None
0.86A 2qd4A-1fi8A:
undetectable
2qd4A-1fi8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
4 LEU A 162
LEU A 456
ILE A 515
ARG A 448
None
0.77A 2qd4A-1ileA:
undetectable
2qd4A-1ileA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE


(Homo sapiens)
PF02898
(NO_synthase)
4 LEU A 305
PRO A 306
LEU A 309
ILE A 215
None
0.82A 2qd4A-1m9qA:
undetectable
2qd4A-1m9qA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME


(Eisenia fetida)
PF00089
(Trypsin)
4 LEU A 123
PRO A 124
LEU A 235
ILE A 238
None
0.84A 2qd4A-1m9uA:
undetectable
2qd4A-1m9uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA


(Thermotoga
maritima)
PF01926
(MMR_HSR1)
PF14714
(KH_dom-like)
4 LEU A 378
PRO A 379
LEU A 382
ILE A 384
None
0.88A 2qd4A-1mkyA:
3.4
2qd4A-1mkyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oft HYPOTHETICAL PROTEIN
PA3008


(Pseudomonas
aeruginosa)
PF03846
(SulA)
4 LEU A  80
PRO A  83
LEU A 104
ILE A 102
None
0.88A 2qd4A-1oftA:
3.9
2qd4A-1oftA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens)
PF00089
(Trypsin)
4 LEU A 123
PRO A 124
LEU A 235
ILE A 238
None
0.87A 2qd4A-1orfA:
undetectable
2qd4A-1orfA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2C
1


(Homo sapiens)
PF02170
(PAZ)
4 LEU A 323
PRO A 324
LEU A 339
ILE A 229
None
0.75A 2qd4A-1si2A:
undetectable
2qd4A-1si2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus)
PF00135
(COesterase)
4 LEU A 313
PRO A 314
LEU A 317
ILE A 378
None
0.86A 2qd4A-1thgA:
3.1
2qd4A-1thgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpa 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE


(Thermotoga
maritima)
PF01128
(IspD)
4 LEU A  36
PRO A  35
LEU A   6
ILE A  50
None
0.82A 2qd4A-1vpaA:
3.0
2qd4A-1vpaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium)
PF00840
(Glyco_hydro_7)
4 LEU A 133
PRO A 134
LEU A 137
ILE A 363
None
0.84A 2qd4A-1z3vA:
undetectable
2qd4A-1z3vA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli)
PF00480
(ROK)
5 LEU A 178
PRO A 177
LEU A 125
ILE A 128
ARG A 127
None
1.36A 2qd4A-1z6rA:
2.8
2qd4A-1z6rA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN


(Bacillus cereus)
PF00903
(Glyoxalase)
4 LEU A 293
PRO A 294
LEU A 297
ILE A 304
None
0.81A 2qd4A-1zswA:
undetectable
2qd4A-1zswA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens)
PF00685
(Sulfotransfer_1)
4 LEU A 115
PRO A 116
LEU A 119
ILE A 126
None
0.83A 2qd4A-2ad1A:
undetectable
2qd4A-2ad1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cex PROTEIN HI0146

(Haemophilus
influenzae)
PF03480
(DctP)
4 LEU A 226
PRO A 227
LEU A 230
ILE A  36
None
0.73A 2qd4A-2cexA:
undetectable
2qd4A-2cexA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Aquifex
aeolicus)
PF14681
(UPRTase)
4 LEU A 116
PRO A 117
LEU A 119
ILE A 144
None
0.77A 2qd4A-2e55A:
3.9
2qd4A-2e55A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN


(Homo sapiens)
PF00089
(Trypsin)
4 LEU A 123
PRO A 124
LEU A 235
ILE A 238
None
0.82A 2qd4A-2ei8A:
undetectable
2qd4A-2ei8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR


(Escherichia
coli)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF)
4 LEU A 339
LEU A  30
ILE A  34
ARG A  37
None
0.85A 2qd4A-2eyqA:
3.3
2qd4A-2eyqA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG


(Escherichia
coli)
PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4)
4 LEU A 357
PRO A 167
LEU A 288
ILE A 291
None
0.77A 2qd4A-2iw1A:
4.0
2qd4A-2iw1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima)
PF00232
(Glyco_hydro_1)
4 LEU A 124
PRO A 125
LEU A 128
ILE A 139
None
0.83A 2qd4A-2j7cA:
undetectable
2qd4A-2j7cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE


(Rauvolfia
serpentina)
PF00232
(Glyco_hydro_1)
4 LEU A 164
PRO A 165
LEU A 168
ILE A 180
None
0.83A 2qd4A-2jf7A:
undetectable
2qd4A-2jf7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE


(Homo sapiens)
PF00232
(Glyco_hydro_1)
4 LEU X 123
PRO X 124
LEU X 127
ILE X 138
None
0.63A 2qd4A-2jfeX:
undetectable
2qd4A-2jfeX:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pce PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Roseovarius
nubinhibens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 215
PRO A 216
LEU A 219
ILE A 221
None
0.52A 2qd4A-2pceA:
3.4
2qd4A-2pceA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pql D7R4 PROTEIN

(Anopheles
gambiae)
PF01395
(PBP_GOBP)
4 LEU A  10
PRO A  11
LEU A  14
ILE A  21
None
None
None
TSS  A 145 (-4.8A)
0.89A 2qd4A-2pqlA:
undetectable
2qd4A-2pqlA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans)
PF14520
(HHH_5)
PF14716
(HHH_8)
4 LEU A  92
PRO A  93
ILE A  26
ARG A 111
None
ZN  A1565 ( 4.2A)
None
None
0.84A 2qd4A-2w9mA:
2.8
2qd4A-2w9mA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Prochlorococcus
marinus)
PF00148
(Oxidored_nitro)
4 LEU C 300
PRO C 299
LEU C 238
ILE C 387
None
0.75A 2qd4A-2ynmC:
undetectable
2qd4A-2ynmC:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1p COLLAGEN ADHESIN
PROTEIN


(Enterococcus
faecalis)
PF05737
(Collagen_bind)
4 LEU A  79
PRO A  80
LEU A  83
ILE A 133
None
0.89A 2qd4A-2z1pA:
undetectable
2qd4A-2z1pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE


(Thermus
thermophilus)
PF01063
(Aminotran_4)
4 LEU A 100
PRO A 101
LEU A 104
ARG A 110
None
0.79A 2qd4A-2zgiA:
undetectable
2qd4A-2zgiA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens)
PF00762
(Ferrochelatase)
5 LEU A 101
PRO A 102
LEU A 107
ILE A 111
ARG A 114
CHD  A   3 ( 4.9A)
CHD  A   3 ( 4.7A)
CHD  A   3 ( 4.6A)
CHD  A   2 ( 4.7A)
CHD  A   2 (-3.6A)
0.73A 2qd4A-3aqiA:
60.7
2qd4A-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv6 METAL-DEPENDENT
HYDROLASE


(Vibrio cholerae)
PF13483
(Lactamase_B_3)
4 LEU A 102
PRO A 101
LEU A  24
ILE A  28
None
0.57A 2qd4A-3bv6A:
undetectable
2qd4A-3bv6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN


(Shigella
flexneri)
PF12468
(TTSSLRR)
PF14496
(NEL)
4 LEU A 138
PRO A 139
LEU A 142
ILE A 145
None
0.73A 2qd4A-3cvrA:
undetectable
2qd4A-3cvrA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
4 LEU A 160
PRO A 159
LEU A 178
ILE A 180
None
0.83A 2qd4A-3djlA:
undetectable
2qd4A-3djlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN


(Homo sapiens)
PF00089
(Trypsin)
4 LEU H 123
PRO H 124
LEU H 235
ILE H 238
None
0.80A 2qd4A-3f6uH:
undetectable
2qd4A-3f6uH:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa)
PF00232
(Glyco_hydro_1)
4 LEU A 135
PRO A 136
LEU A 139
ILE A 151
LEU  A 135 ( 0.6A)
PRO  A 136 ( 1.1A)
LEU  A 139 ( 0.6A)
ILE  A 151 ( 0.4A)
0.81A 2qd4A-3gnrA:
undetectable
2qd4A-3gnrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG


(Aquifex
aeolicus)
PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N)
4 LEU A 151
PRO A 152
LEU A 155
ILE A 132
None
0.82A 2qd4A-3hjlA:
undetectable
2qd4A-3hjlA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyi PROTEIN DUF199/WHIA

(Thermotoga
maritima)
PF02650
(HTH_WhiA)
PF10298
(WhiA_N)
PF14527
(LAGLIDADG_WhiA)
4 LEU A 244
PRO A 245
LEU A 248
ILE A 284
None
0.79A 2qd4A-3hyiA:
undetectable
2qd4A-3hyiA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR


(Lactobacillus
salivarius)
PF07537
(CamS)
4 LEU A 343
PRO A 344
LEU A 314
ILE A 316
None
0.70A 2qd4A-3ib5A:
undetectable
2qd4A-3ib5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY


(Rhodospirillum
rubrum)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
4 LEU A 233
PRO A 234
LEU A 237
ILE A  80
None
0.79A 2qd4A-3ifrA:
undetectable
2qd4A-3ifrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT


(Methanosarcina
mazei)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
4 LEU A 425
PRO A 426
LEU A 429
ILE A 232
None
0.85A 2qd4A-3khkA:
undetectable
2qd4A-3khkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Jannaschia sp.
CCS1)
PF07848
(PaaX)
4 LEU A 128
PRO A 129
LEU A 132
ILE A 144
None
0.68A 2qd4A-3l09A:
undetectable
2qd4A-3l09A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE


(Salmonella
enterica)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
4 LEU A 559
PRO A 560
LEU A 562
ILE A 584
None
0.86A 2qd4A-3m07A:
undetectable
2qd4A-3m07A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkv PUTATIVE
AMIDOHYDROLASE


(unidentified)
PF01979
(Amidohydro_1)
4 LEU A 401
PRO A 400
LEU A 413
ILE A  48
None
0.83A 2qd4A-3mkvA:
undetectable
2qd4A-3mkvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN


(Escherichia
virus Qbeta)
no annotation 4 LEU G 454
PRO G 455
LEU G 458
ILE G 423
None
0.88A 2qd4A-3mmpG:
undetectable
2qd4A-3mmpG:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN


(Bacteroides
thetaiotaomicron)
PF13306
(LRR_5)
4 LEU A 277
PRO A 278
LEU A 281
ILE A 284
None
0.86A 2qd4A-3sb4A:
undetectable
2qd4A-3sb4A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis)
PF00232
(Glyco_hydro_1)
4 LEU A 160
PRO A 161
LEU A 164
ILE A 176
None
0.77A 2qd4A-3wq4A:
undetectable
2qd4A-3wq4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri)
PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70)
4 LEU A1633
PRO A1634
LEU A1637
ILE A 810
None
0.87A 2qd4A-4amcA:
undetectable
2qd4A-4amcA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y)
no annotation 4 LEU A 169
PRO A 170
LEU A 173
ILE A 187
None
0.70A 2qd4A-4b2nA:
undetectable
2qd4A-4b2nA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN


(Bacteroides
eggerthii)
no annotation 4 LEU A 533
PRO A 534
LEU A 537
ILE A 546
None
0.80A 2qd4A-4ecoA:
undetectable
2qd4A-4ecoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg9 UNCHARACTERIZED
PROTEIN
SAOUHSC_02783


(Staphylococcus
aureus)
PF04507
(DUF576)
4 LEU A 144
PRO A 145
LEU A 149
ILE A 153
None
0.89A 2qd4A-4eg9A:
undetectable
2qd4A-4eg9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG


(Thermotoga
maritima)
PF01706
(FliG_C)
PF14841
(FliG_M)
4 LEU B 150
PRO B 151
LEU B 154
ILE B 131
None
0.71A 2qd4A-4fhrB:
undetectable
2qd4A-4fhrB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF13306
(LRR_5)
4 LEU A 144
PRO A 145
LEU A 148
ILE A 151
None
0.81A 2qd4A-4fs7A:
undetectable
2qd4A-4fs7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF13306
(LRR_5)
4 LEU A 212
PRO A 213
LEU A 216
ILE A 219
None
0.82A 2qd4A-4fs7A:
undetectable
2qd4A-4fs7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF13306
(LRR_5)
4 LEU A 393
PRO A 394
LEU A 397
ILE A 377
None
0.68A 2qd4A-4fs7A:
undetectable
2qd4A-4fs7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN


(Eubacterium
ventriosum)
PF13306
(LRR_5)
4 LEU A 348
PRO A 349
LEU A 352
ILE A 355
None
0.78A 2qd4A-4h09A:
undetectable
2qd4A-4h09A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcy THIAMINASE-I

(Naegleria
gruberi)
no annotation 4 LEU A  16
PRO A  17
LEU A  28
ILE A  32
None
0.61A 2qd4A-4hcyA:
undetectable
2qd4A-4hcyA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hlu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA


(Thermotoga
maritima)
no annotation 4 LEU D1155
PRO D1158
LEU D1186
ILE D1184
None
ACT  D1302 (-3.5A)
None
None
0.83A 2qd4A-4hluD:
undetectable
2qd4A-4hluD:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN


(Legionella
longbeachae)
no annotation 4 LEU A 626
PRO A 627
ILE A 634
ARG A 637
None
0.71A 2qd4A-4jzaA:
2.5
2qd4A-4jzaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens)
PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2)
4 LEU A 323
PRO A 324
LEU A 339
ILE A 229
None
0.70A 2qd4A-4krfA:
4.8
2qd4A-4krfA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m03 SERINE-RICH ADHESIN
FOR PLATELETS


(Staphylococcus
aureus)
PF05345
(He_PIG)
4 LEU A 156
PRO A 157
LEU A 160
ILE A 169
None
0.87A 2qd4A-4m03A:
undetectable
2qd4A-4m03A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1


(Homo sapiens)
PF03985
(Paf1)
PF04004
(Leo1)
4 LEU A 108
PRO A 109
LEU A 112
ILE A 150
None
0.77A 2qd4A-4m6tA:
undetectable
2qd4A-4m6tA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmp SIALIC ACID BINDING
PROTEIN


(Pasteurella
multocida)
PF03480
(DctP)
4 LEU A 228
PRO A 229
LEU A 232
ILE A  38
None
0.79A 2qd4A-4mmpA:
undetectable
2qd4A-4mmpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN


(Fusobacterium
nucleatum)
PF03480
(DctP)
4 LEU A 227
PRO A 228
LEU A 231
ILE A  37
None
0.81A 2qd4A-4mnpA:
undetectable
2qd4A-4mnpA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n18 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN


(Klebsiella
pneumoniae)
PF02826
(2-Hacid_dh_C)
4 LEU A  74
PRO A  75
LEU A  78
ILE A  64
None
0.81A 2qd4A-4n18A:
5.5
2qd4A-4n18A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzy PROBABLE THYMIDYLATE
KINASE


(Sulfurisphaera
tokodaii)
PF02223
(Thymidylate_kin)
4 LEU A   6
PRO A 122
ILE A  79
ARG A  74
None
PEG  A 307 (-4.0A)
None
PEG  A 304 ( 3.8A)
0.88A 2qd4A-4nzyA:
undetectable
2qd4A-4nzyA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oaq R-SPECIFIC CARBONYL
REDUCTASE


(Candida
parapsilosis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 LEU A 176
PRO A 175
LEU A 254
ILE A 191
None
0.82A 2qd4A-4oaqA:
2.1
2qd4A-4oaqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE


(Bacteroides
fragilis)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C)
4 LEU A  71
PRO A  72
LEU A  75
ILE A  84
None
0.83A 2qd4A-4ogzA:
2.7
2qd4A-4ogzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE


(Escherichia
coli)
PF06315
(AceK)
4 LEU A 160
PRO A 161
LEU A 162
ILE A 226
None
0.83A 2qd4A-4p69A:
undetectable
2qd4A-4p69A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrm FLAGELLAR MOTOR
SWITCH PROTEIN FLIG


(Thermotoga
maritima)
PF14841
(FliG_M)
4 LEU B 150
PRO B 151
LEU B 154
ILE B 131
None
0.76A 2qd4A-4qrmB:
undetectable
2qd4A-4qrmB:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE


(Oryza sativa)
PF00232
(Glyco_hydro_1)
4 LEU A 136
PRO A 137
LEU A 140
ILE A 152
None
0.79A 2qd4A-4re2A:
undetectable
2qd4A-4re2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uow TITIN

(Homo sapiens)
PF07679
(I-set)
4 LEU 1  29
LEU 1  67
ILE 1  69
ARG 1  55
None
0.73A 2qd4A-4uow1:
undetectable
2qd4A-4uow1:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)


(Mycobacterium
tuberculosis)
PF01180
(DHO_dh)
4 LEU A  62
PRO A  61
LEU A 311
ILE A 294
None
0.75A 2qd4A-4xq6A:
undetectable
2qd4A-4xq6A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B


(Caenorhabditis
elegans)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
4 LEU A 523
LEU A 520
ILE A 586
ARG A 551
None
0.77A 2qd4A-4y9lA:
undetectable
2qd4A-4y9lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yer ABC TRANSPORTER
ATP-BINDING PROTEIN


(Thermotoga
maritima)
PF00005
(ABC_tran)
PF13732
(DUF4162)
4 LEU A 159
PRO A 162
LEU A 191
ILE A 189
None
0.84A 2qd4A-4yerA:
undetectable
2qd4A-4yerA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263

(Nanoarchaeum
equitans)
PF00006
(ATP-synt_ab)
4 LEU B   8
PRO B   7
LEU B  42
ILE B  32
None
0.84A 2qd4A-5bn4B:
2.6
2qd4A-5bn4B:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263


(Nanoarchaeum
equitans;
Nanoarchaeum
equitans)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
PF00006
(ATP-synt_ab)
4 PRO B 101
LEU A  87
ILE A  90
ARG A  85
None
0.82A 2qd4A-5bn4B:
2.6
2qd4A-5bn4B:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR


(Homo sapiens)
PF00089
(Trypsin)
4 LEU E 123
PRO E 124
LEU E 235
ILE E 238
None
0.85A 2qd4A-5brrE:
undetectable
2qd4A-5brrE:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda)
PF00232
(Glyco_hydro_1)
4 LEU A 145
PRO A 146
LEU A 149
ILE A 160
None
0.82A 2qd4A-5cg0A:
undetectable
2qd4A-5cg0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB


(Mus musculus)
PF00784
(MyTH4)
4 LEU A1115
LEU A1112
ILE A1111
ARG A1108
None
0.85A 2qd4A-5f3yA:
undetectable
2qd4A-5f3yA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffx MARR FAMILY
REGULATORY PROTEIN


(Staphylococcus
aureus)
PF12802
(MarR_2)
4 LEU A  37
LEU A  40
ILE A  77
ARG A  79
None
None
None
SO4  A 202 ( 3.9A)
0.86A 2qd4A-5ffxA:
undetectable
2qd4A-5ffxA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome)
PF00232
(Glyco_hydro_1)
4 LEU A 129
PRO A 130
LEU A 133
ILE A 144
None
0.80A 2qd4A-5gnxA:
undetectable
2qd4A-5gnxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540


(Arabidopsis
thaliana)
PF13855
(LRR_8)
4 LEU B 523
PRO B 524
LEU B 527
ILE B 530
None
0.72A 2qd4A-5hz1B:
undetectable
2qd4A-5hz1B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE


(Thermotoga
neapolitana)
PF00232
(Glyco_hydro_1)
4 LEU A 122
PRO A 123
LEU A 126
ILE A 137
None
0.76A 2qd4A-5idiA:
undetectable
2qd4A-5idiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL


(Rhodoferax
ferrireducens)
PF03480
(DctP)
4 LEU A 253
PRO A 254
LEU A 257
ILE A  61
None
0.85A 2qd4A-5im2A:
undetectable
2qd4A-5im2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE


(Bacillus
anthracis)
PF04127
(DFP)
4 LEU A 376
PRO A 377
LEU A 379
ARG A 386
None
0.82A 2qd4A-5intA:
4.2
2qd4A-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1


(Homo sapiens)
PF12859
(ANAPC1)
4 LEU A1657
PRO A1658
LEU A1663
ILE A1666
None
0.89A 2qd4A-5lcwA:
undetectable
2qd4A-5lcwA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpt CITRININ POLYKETIDE
SYNTHASE


(Monascus
purpureus)
PF08242
(Methyltransf_12)
4 LEU A1874
LEU A1879
ILE A1845
ARG A1846
None
0.71A 2qd4A-5mptA:
2.2
2qd4A-5mptA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-)
no annotation 4 LEU A 305
PRO A 306
LEU A 239
ILE A 261
GOL  A 504 (-3.6A)
None
None
None
0.84A 2qd4A-5ns8A:
undetectable
2qd4A-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL


(Homo sapiens)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
4 LEU A 554
PRO A 555
LEU A 558
ILE A 533
None
0.70A 2qd4A-5o1pA:
3.6
2qd4A-5o1pA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae)
no annotation 4 LEU B 342
PRO B 343
LEU B 359
ILE B 363
None
0.53A 2qd4A-5swiB:
undetectable
2qd4A-5swiB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
PROTEIN NAM8
56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
no annotation
no annotation
no annotation
4 LEU F 438
PRO F 439
LEU D 342
ILE G 256
None
0.86A 2qd4A-5uz5F:
undetectable
2qd4A-5uz5F:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5


(Saccharomyces
cerevisiae)
PF13401
(AAA_22)
PF14630
(ORC5_C)
4 LEU E 108
PRO E 105
LEU E  74
ILE E  77
None
0.75A 2qd4A-5v8fE:
undetectable
2qd4A-5v8fE:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens)
no annotation 4 LEU A 198
PRO A 199
LEU A 202
ILE A 214
None
0.77A 2qd4A-5vanA:
undetectable
2qd4A-5vanA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens)
no annotation 4 LEU A 326
PRO A 327
LEU A 342
ILE A 232
None
0.66A 2qd4A-5vm9A:
5.3
2qd4A-5vm9A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN L


(Human
betaherpesvirus
5)
PF01801
(Cytomega_gL)
4 LEU B 253
PRO B 254
LEU B 257
ILE B 219
None
0.70A 2qd4A-5vocB:
undetectable
2qd4A-5vocB:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens)
no annotation 4 LEU A 325
PRO A 326
LEU A 341
ILE A 231
None
0.80A 2qd4A-5weaA:
5.1
2qd4A-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)


(Helicobacter
pylori)
no annotation 4 LEU A  63
PRO A  62
LEU A 309
ILE A 292
None
0.77A 2qd4A-6b8sA:
undetectable
2qd4A-6b8sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN


(Carboxydothermus
hydrogenoformans)
no annotation 4 LEU A 108
PRO A 109
LEU A 112
ILE A 116
None
0.87A 2qd4A-6enoA:
3.3
2qd4A-6enoA:
undetectable