SIMILAR PATTERNS OF AMINO ACIDS FOR 2QD4_A_CHDA801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		5 SER A 121
HIS A 183
LEU A 185
PRO A 186
TRP A 230
 MP1  A 800 (-3.4A)
MP1  A 800 (-3.6A)
MP1  A 800 (-4.8A)
MP1  A 800 (-4.6A)
None
 1.01A 2qd4A-1c9eA:
35.0		 2qd4A-1c9eA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		5 LEU A 173
PHE A 143
LEU A 295
VAL A 123
VAL A 272
 None
 1.29A 2qd4A-1drtA:
undetectable		 2qd4A-1drtA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 LEU A 164
LEU A  85
LEU A 151
PRO A 150
VAL A 121
 None
 1.26A 2qd4A-1gz0A:
undetectable		 2qd4A-1gz0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9m MOLYBDENUM-BINDING-P
ROTEIN

(Azotobacter
vinelandii) 		PF03459
(TOBE) 		5 LEU A  81
LEU A  29
LEU A 138
VAL A  55
VAL A  59
 None
 1.20A 2qd4A-1h9mA:
undetectable		 2qd4A-1h9mA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		10 LEU A  62
PHE A  63
ARG A  87
SER A 169
HIS A 235
LEU A 237
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 0.72A 2qd4A-1lbqA:
48.6		 2qd4A-1lbqA:
49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		10 LEU A  62
PHE A  63
GLN A  94
SER A 169
HIS A 235
LEU A 237
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 0.56A 2qd4A-1lbqA:
48.6		 2qd4A-1lbqA:
49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		8 PHE A  63
LEU A  68
ARG A  87
SER A 169
HIS A 235
LEU A 237
VAL A 277
TRP A 282
 None
 1.06A 2qd4A-1lbqA:
48.6		 2qd4A-1lbqA:
49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 SER A 167
HIS A 235
LEU A 237
VAL A 241
TRP A 282
 None
 1.29A 2qd4A-1lbqA:
48.6		 2qd4A-1lbqA:
49.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvh CRYPTIC LOCI
REGULATOR 4

(Schizosaccharomyces
pombe) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 LEU A 433
PHE A 383
LEU A 385
LEU A 245
VAL A 249
 None
 1.39A 2qd4A-1mvhA:
undetectable		 2qd4A-1mvhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s28 ORF1

(Pseudomonas
savastanoi) 		PF05932
(CesT) 		5 LEU A  10
PHE A   7
LEU A  14
LEU A 119
VAL A  40
 None
 1.38A 2qd4A-1s28A:
undetectable		 2qd4A-1s28A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4z ADAPTIVE-RESPONSE
SENSORY-KINASE SASA

(Synechococcus
elongatus) 		PF07689
(KaiB) 		5 LEU A  86
SER A  82
LEU A  64
VAL A  80
VAL A  49
 None
 1.29A 2qd4A-1t4zA:
2.9		 2qd4A-1t4zA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 LEU A  42
LEU A  53
LEU A  23
PRO A  21
VAL A  61
 None
 1.40A 2qd4A-1vrpA:
undetectable		 2qd4A-1vrpA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130

(Homo sapiens) 		PF00179
(UQ_con) 		5 LEU A 109
ARG A  11
LEU A  93
PRO A  68
VAL A  70
 None
 1.30A 2qd4A-1yrvA:
undetectable		 2qd4A-1yrvA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2

(Archaeoglobus
fulgidus) 		PF02552
(CO_dh) 		5 LEU A 171
LEU A 174
LEU A 111
PRO A  38
VAL A  64
 None
 0.92A 2qd4A-1ytlA:
3.4		 2qd4A-1ytlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		5 LEU X 526
PHE X 523
LEU X 499
GLN X 414
VAL X 713
 None
 1.36A 2qd4A-1z3iX:
undetectable		 2qd4A-1z3iX:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		5 LEU A 319
LEU A 323
ARG A 370
LEU A 285
PRO A 349
 None
 1.29A 2qd4A-2aynA:
undetectable		 2qd4A-2aynA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN

(Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  21
LEU A 152
GLN A 133
LEU A 264
VAL A 224
 None
 1.20A 2qd4A-2be7A:
2.5		 2qd4A-2be7A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 1.03A 2qd4A-2dc0A:
undetectable		 2qd4A-2dc0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpw HYPOTHETICAL PROTEIN
TTHA0179

(Thermus
thermophilus) 		PF12804
(NTP_transf_3) 		5 LEU A  42
LEU A  88
LEU A 213
PRO A 117
VAL A 115
 None
 1.38A 2qd4A-2dpwA:
2.2		 2qd4A-2dpwA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		5 LEU A 199
PHE A 238
LEU A 195
PRO A 249
VAL A 188
 None
 1.38A 2qd4A-2eijA:
undetectable		 2qd4A-2eijA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN

(Clytia gregaria) 		PF01353
(GFP) 		5 LEU A 220
LEU A  67
SER A  65
VAL A 109
VAL A  58
 None
GYS  A  68 ( 4.2A)
None
None
None
 1.28A 2qd4A-2hpwA:
undetectable		 2qd4A-2hpwA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth) 		5 LEU A  95
LEU A 126
ARG A  90
VAL A   4
VAL A 153
 None
 1.26A 2qd4A-2is8A:
6.1		 2qd4A-2is8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		5 LEU A 249
SER A 246
LEU A  83
VAL A  82
VAL A 263
 None
 1.33A 2qd4A-2nq2A:
undetectable		 2qd4A-2nq2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		5 LEU A  60
LEU A   6
ARG A 282
SER A 245
LEU A 265
 None
 1.39A 2qd4A-2yb4A:
undetectable		 2qd4A-2yb4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yru STEROID RECEPTOR RNA
ACTIVATOR 1

(Mus musculus) 		PF07304
(SRA1) 		5 LEU A  45
LEU A  48
LEU A  87
VAL A  61
VAL A  69
 None
 1.34A 2qd4A-2yruA:
undetectable		 2qd4A-2yruA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU B 425
LEU B 428
GLN B 396
LEU B 384
VAL B 410
 None
 1.39A 2qd4A-2z7xB:
undetectable		 2qd4A-2z7xB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		5 LEU A 352
PHE A 353
LEU A 356
LEU A  11
PRO A  12
 None
 1.28A 2qd4A-3a9sA:
2.3		 2qd4A-3a9sA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aj2 CELLULOSE SYNTHASE
OPERON PROTEIN D

(Komagataeibacter
xylinus) 		PF03500
(Cellsynth_D) 		5 LEU A  17
PHE A  13
LEU A  90
PRO A  91
TRP A  69
 None
 1.25A 2qd4A-3aj2A:
undetectable		 2qd4A-3aj2A:
18.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		11 LEU A  92
PHE A  93
LEU A  98
GLN A 122
SER A 197
HIS A 263
LEU A 265
PRO A 266
VAL A 269
VAL A 305
TRP A 310
 CHD  A   1 (-4.8A)
CHD  A   1 ( 4.7A)
CHD  A   1 (-4.3A)
CHD  A   1 ( 4.1A)
CHD  A   1 (-3.0A)
CHD  A   1 (-4.3A)
None
CHD  A   2 ( 4.5A)
None
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
 0.72A 2qd4A-3aqiA:
60.7		 2qd4A-3aqiA:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 SER A 195
HIS A 263
LEU A 265
VAL A 269
TRP A 310
 None
CHD  A   1 (-4.3A)
None
None
CHD  A   2 (-4.7A)
 1.27A 2qd4A-3aqiA:
60.7		 2qd4A-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 LEU A  94
GLN A 286
LEU A 179
PRO A 181
VAL A 208
 None
 1.24A 2qd4A-3b4wA:
undetectable		 2qd4A-3b4wA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4m TUMOR NECROSIS
FACTOR,
ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 2

(Homo sapiens) 		PF05527
(DUF758) 		5 LEU A 116
LEU A 120
LEU A  63
VAL A 146
VAL A  45
 None
 1.27A 2qd4A-3f4mA:
undetectable		 2qd4A-3f4mA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 1.00A 2qd4A-3fxiA:
undetectable		 2qd4A-3fxiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU B 801
LEU B 527
GLN B1082
PRO B 510
VAL B 508
 None
 1.35A 2qd4A-3h0gB:
undetectable		 2qd4A-3h0gB:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A  65
LEU A 331
GLN A 323
LEU A 211
VAL A 358
 None
 1.32A 2qd4A-3h5cA:
undetectable		 2qd4A-3h5cA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		5 LEU A 113
ARG A  10
SER A 153
PRO A 181
VAL A 182
 None
FAD  A1001 (-4.0A)
None
FAD  A1001 (-4.4A)
None
 1.16A 2qd4A-3h8lA:
undetectable		 2qd4A-3h8lA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		5 LEU X   7
PRO X   3
VAL X   2
VAL X 158
TRP X 162
 None
 1.34A 2qd4A-3j8gX:
2.9		 2qd4A-3j8gX:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 LEU A  24
LEU A  38
PRO A  99
VAL A  96
VAL A  74
 None
 1.39A 2qd4A-3la4A:
undetectable		 2qd4A-3la4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.23A 2qd4A-3m1mA:
undetectable		 2qd4A-3m1mA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt7 HEMOGLOBIN II

(Phacoides
pectinatus) 		PF00042
(Globin) 		5 LEU A 107
LEU A 143
ARG A 100
GLN A  65
LEU A  86
 HEM  A 500 (-4.8A)
None
HEM  A 500 (-2.9A)
HEM  A 500 ( 3.6A)
None
 1.38A 2qd4A-3pt7A:
undetectable		 2qd4A-3pt7A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uat DISKS LARGE HOMOLOG
1

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 LEU A 588
PHE A 608
GLN A 826
LEU A 583
VAL A 614
 None
 0.98A 2qd4A-3uatA:
undetectable		 2qd4A-3uatA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
LEU A 369
VAL A 380
VAL A 458
 None
 0.97A 2qd4A-3v4oA:
2.3		 2qd4A-3v4oA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 LEU A 143
PHE A 146
LEU A 124
LEU A 203
VAL A 221
 IPA  A 401 (-4.8A)
None
None
None
None
 1.39A 2qd4A-3wafA:
undetectable		 2qd4A-3wafA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 518
LEU A 496
GLN A 508
LEU A 421
VAL A 419
 None
 1.37A 2qd4A-3wpeA:
undetectable		 2qd4A-3wpeA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		5 LEU A 379
LEU A 276
PRO A 277
VAL A 280
TRP A 139
 None
 0.77A 2qd4A-3zdpA:
undetectable		 2qd4A-3zdpA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A 267
LEU A 263
LEU A 211
VAL A 237
VAL A  45
 None
 1.26A 2qd4A-3zg6A:
undetectable		 2qd4A-3zg6A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 LEU A  53
PHE A  54
LEU A 364
VAL A  27
VAL A 436
 None
 1.39A 2qd4A-3zvtA:
undetectable		 2qd4A-3zvtA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 321
PHE A 325
LEU A 320
LEU A 340
VAL A 336
 None
 1.34A 2qd4A-4a27A:
2.9		 2qd4A-4a27A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad8 DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		5 LEU A 489
PHE A  56
LEU A 492
SER A 458
LEU A 154
 None
 1.32A 2qd4A-4ad8A:
undetectable		 2qd4A-4ad8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxx TRANSCRIPTION FACTOR
BYE1

(Saccharomyces
cerevisiae) 		PF07500
(TFIIS_M) 		5 LEU X 309
PHE X 245
LEU X 313
LEU X 330
VAL X 325
 None
 1.35A 2qd4A-4bxxX:
undetectable		 2qd4A-4bxxX:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		5 LEU A 264
PHE A 257
LEU A 285
LEU A 324
PRO A 325
 None
 1.21A 2qd4A-4cp6A:
undetectable		 2qd4A-4cp6A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		5 LEU A 136
LEU A 144
ARG A 101
LEU A   4
VAL A 126
 None
None
GOL  A 407 (-3.9A)
None
None
 1.13A 2qd4A-4e69A:
3.4		 2qd4A-4e69A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		5 LEU A 210
PHE A 218
LEU A  31
PRO A  32
VAL A  35
 None
 1.25A 2qd4A-4fxqA:
undetectable		 2qd4A-4fxqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glp MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Homo sapiens) 		PF13516
(LRR_6) 		5 LEU A 144
LEU A 147
LEU A 126
VAL A 152
VAL A 107
 None
 1.33A 2qd4A-4glpA:
undetectable		 2qd4A-4glpA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
LEU A 369
VAL A 380
VAL A 458
 None
 0.85A 2qd4A-4i1pA:
2.3		 2qd4A-4i1pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7

(Homo sapiens) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 LEU A  95
LEU A 119
LEU A 167
PRO A 168
VAL A 185
 None
 1.00A 2qd4A-4irqA:
2.8		 2qd4A-4irqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izk YELLOWTAIL ASCITES
VIRUS (YAV) VP4
PROTEASE

(Yellowtail
ascites virus) 		PF01768
(Birna_VP4) 		5 ARG A 515
LEU A 560
PRO A 544
VAL A 653
VAL A 546
 None
 1.17A 2qd4A-4izkA:
undetectable		 2qd4A-4izkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmf PROBABLE CHAPERONE

(Pseudomonas
aeruginosa) 		PF05932
(CesT) 		5 LEU B  12
LEU B  39
SER B  29
LEU B  36
VAL B 109
 None
 1.17A 2qd4A-4jmfB:
undetectable		 2qd4A-4jmfB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k82 LV-RANASPUMIN
(LV-RSN-1)

(Leptodactylus
vastus) 		no annotation 5 LEU A 198
PHE A 191
LEU A 201
LEU A 138
VAL A 145
 None
 1.25A 2qd4A-4k82A:
undetectable		 2qd4A-4k82A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 LEU A 203
LEU A 202
ARG A  75
VAL A 105
VAL A  14
 None
 1.29A 2qd4A-4lbwA:
4.1		 2qd4A-4lbwA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		5 LEU A 223
PHE A 192
LEU A 226
LEU A 321
VAL A 331
 None
 1.30A 2qd4A-4lctA:
undetectable		 2qd4A-4lctA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc5 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A 175
PHE A 258
LEU A 105
GLN A 239
SER A 101
 None
 1.34A 2qd4A-4mc5A:
undetectable		 2qd4A-4mc5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Escherichia
fergusonii) 		PF03480
(DctP) 		5 PHE A 121
GLN A 133
LEU A 311
PRO A 308
VAL A 307
 None
None
IOD  A 436 ( 4.4A)
None
None
 1.25A 2qd4A-4p1eA:
undetectable		 2qd4A-4p1eA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		5 LEU A 338
LEU A 332
LEU A 372
VAL A 353
VAL A 315
 None
 1.35A 2qd4A-4perA:
undetectable		 2qd4A-4perA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9v TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 3

(Homo sapiens) 		PF05527
(DUF758) 		5 LEU A 222
LEU A 226
LEU A 169
VAL A 252
VAL A 151
 None
 1.18A 2qd4A-4q9vA:
undetectable		 2qd4A-4q9vA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN

(Pectobacterium
atrosepticum) 		PF13416
(SBP_bac_8) 		5 LEU A 233
PHE A 234
LEU A 187
VAL A 245
VAL A 196
 None
 1.27A 2qd4A-4ry1A:
undetectable		 2qd4A-4ry1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		5 PHE A 471
GLN A 582
LEU A 516
PRO A 526
VAL A 524
 None
 1.26A 2qd4A-4uj6A:
undetectable		 2qd4A-4uj6A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 388
LEU A 379
PRO A 401
VAL A 381
VAL A 141
 None
 1.18A 2qd4A-4wpzA:
undetectable		 2qd4A-4wpzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE
ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
no annotation 		5 LEU D 193
GLN D 151
HIS A 368
LEU A 372
VAL D 326
 None
 1.37A 2qd4A-4x28D:
undetectable		 2qd4A-4x28D:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq2 CALE6

(Micromonospora
echinospora) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A  57
LEU A 244
PRO A 178
VAL A 179
VAL A 211
 None
 1.27A 2qd4A-4xq2A:
2.2		 2qd4A-4xq2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		5 LEU A 151
LEU A  31
LEU A 138
PRO A 135
VAL A 134
 None
 1.39A 2qd4A-4y9wA:
undetectable		 2qd4A-4y9wA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU B 180
LEU B 201
LEU B 249
PRO B 245
VAL B 220
 None
 1.36A 2qd4A-4yebB:
undetectable		 2qd4A-4yebB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		5 LEU A 343
LEU A 262
LEU A 277
VAL A 275
VAL A 305
 None
 1.19A 2qd4A-5cdhA:
undetectable		 2qd4A-5cdhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A  47
PHE A 541
GLN A  95
PRO A  64
VAL A 271
 None
 1.36A 2qd4A-5fkuA:
1.5		 2qd4A-5fkuA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1

(Homo sapiens) 		no annotation 5 LEU A  81
LEU A  85
HIS A  42
LEU A  10
VAL A  64
 MLY  A  78 ( 4.3A)
None
None
None
None
 1.13A 2qd4A-5forA:
3.2		 2qd4A-5forA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		5 LEU A 315
LEU A  67
LEU A 359
PRO A 358
VAL A  44
 None
 1.33A 2qd4A-5fqlA:
undetectable		 2qd4A-5fqlA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		5 LEU A  77
PHE A 170
LEU A  76
ARG A 176
LEU A 274
 None
 1.31A 2qd4A-5gkvA:
undetectable		 2qd4A-5gkvA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		5 LEU A 397
LEU A 400
GLN A 454
LEU A  16
VAL A 129
 None
FAD  A 601 (-4.6A)
None
None
None
 1.31A 2qd4A-5j7xA:
undetectable		 2qd4A-5j7xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 LEU A  87
GLN A 283
LEU A 176
PRO A 178
VAL A 205
 None
 1.28A 2qd4A-5jryA:
2.9		 2qd4A-5jryA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens;
Homo sapiens) 		no annotation
PF04858
(TH1) 		5 LEU B 239
LEU A  61
LEU A  75
PRO A 101
VAL A  68
 None
 1.35A 2qd4A-5l3xB:
undetectable		 2qd4A-5l3xB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjr PROTEIN THF1

(Thermosynechococcus
elongatus) 		PF11264
(ThylakoidFormat) 		5 LEU A  40
HIS A 127
LEU A 167
PRO A 168
VAL A 172
 None
 1.38A 2qd4A-5mjrA:
undetectable		 2qd4A-5mjrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU B 227
LEU B 200
ARG B 229
LEU B 216
VAL B 211
 None
 1.21A 2qd4A-5mkkB:
undetectable		 2qd4A-5mkkB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv9 BOR1P BORON
TRANSPORTER

(Saccharomyces
mikatae) 		PF00955
(HCO3_cotransp) 		5 PHE A 330
LEU A 155
GLN A 358
PRO A 162
VAL A 491
 None
 1.37A 2qd4A-5sv9A:
undetectable		 2qd4A-5sv9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN

(Thermoactinomyces
vulgaris) 		PF00668
(Condensation) 		5 LEU A1236
LEU A1199
SER A1091
LEU A1115
VAL A1117
 None
 1.32A 2qd4A-5t3eA:
undetectable		 2qd4A-5t3eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.37A 2qd4A-5vl1A:
undetectable		 2qd4A-5vl1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6

(Homo sapiens) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		5 LEU A 451
PHE A 311
LEU A 319
LEU A 348
VAL A 423
 None
 1.38A 2qd4A-5vxzA:
undetectable		 2qd4A-5vxzA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 5 LEU A 134
PRO A 135
VAL A 138
VAL A  87
TRP A 214
 None
 1.23A 2qd4A-5y4gA:
undetectable		 2qd4A-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 5 LEU B 174
LEU B 176
GLN B 330
LEU B 235
VAL B  91
 None
 1.38A 2qd4A-5yewB:
2.1		 2qd4A-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh0 DRFAM20C1

(Danio rerio) 		no annotation 5 LEU A 297
LEU A 487
ARG A 301
LEU A 470
VAL A 532
 None
 1.33A 2qd4A-5yh0A:
undetectable		 2qd4A-5yh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 5 LEU A  63
LEU A  61
PRO A 111
VAL A  99
TRP A 113
 None
 1.36A 2qd4A-5z5dA:
undetectable		 2qd4A-5z5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 LEU A 521
LEU A 499
GLN A 511
LEU A 422
VAL A 420
 None
 1.26A 2qd4A-5zlnA:
undetectable		 2qd4A-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-9
PROTEASOME SUBUNIT
BETA TYPE-10

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 LEU A  45
LEU A  98
ARG B  84
LEU A  63
VAL A  82
 None
 1.35A 2qd4A-6avoA:
undetectable		 2qd4A-6avoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER

(Yersinia pestis) 		no annotation 5 LEU A 145
LEU A  34
SER A  32
PRO A 299
VAL A 124
 None
None
NA  A 401 ( 4.1A)
None
None
 1.10A 2qd4A-6b2yA:
undetectable		 2qd4A-6b2yA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 5 LEU A 235
PHE A 238
LEU A 230
PRO A 197
VAL A 191
 None
 1.37A 2qd4A-6brmA:
undetectable		 2qd4A-6brmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 LEU A 329
LEU A 323
LEU A  83
PRO A  84
VAL A  87
 None
None
None
None
SO4  A 504 ( 4.1A)
 1.24A 2qd4A-6czxA:
undetectable		 2qd4A-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum) 		no annotation 5 LEU A 265
LEU A 364
LEU A 347
PRO A 367
VAL A 352
 None
 1.38A 2qd4A-6d47A:
undetectable		 2qd4A-6d47A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 5 LEU A 373
GLN A 365
LEU A 247
PRO A 248
VAL A 251
 None
 1.10A 2qd4A-6dllA:
undetectable		 2qd4A-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 740
LEU A 744
GLN A 809
SER A 747
LEU A 785
 None
 1.38A 2qd4A-6emkA:
undetectable		 2qd4A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ggp AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		no annotation 5 LEU A 231
LEU A  57
ARG A 229
LEU A  30
VAL A  32
 None
 1.27A 2qd4A-6ggpA:
undetectable		 2qd4A-6ggpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpc -

(-) 		no annotation 5 LEU A 126
LEU A  38
ARG A 124
LEU A  11
VAL A  13
 None
 1.33A 2qd4A-6gpcA:
undetectable		 2qd4A-6gpcA:
undetectable