SIMILAR PATTERNS OF AMINO ACIDS FOR 2QD3_A_CHDA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9n U2A'

(Homo sapiens) 		PF14580
(LRR_9) 		5 LEU A 109
LEU A 118
LEU A 145
ILE A  79
VAL A 125
 None
 1.18A 2qd3A-1a9nA:
undetectable		 2qd3A-1a9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		5 LEU A 387
LEU A 347
ILE A 391
THR A 277
VAL A 353
 None
None
TCH  A 602 (-3.5A)
None
TCH  A 602 (-3.7A)
 1.26A 2qd3A-1aqlA:
undetectable		 2qd3A-1aqlA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 100
LEU A  96
LEU A  92
ARG A 223
VAL A 292
 None
 1.03A 2qd3A-1fc4A:
3.5		 2qd3A-1fc4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 LEU A 148
LEU A 143
ARG A 103
ILE A 123
VAL A 616
 None
 1.06A 2qd3A-1h0hA:
undetectable		 2qd3A-1h0hA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		5 LEU A1175
LEU A1197
LEU A1217
ILE A1158
THR A1241
 None
 1.29A 2qd3A-1jl5A:
undetectable		 2qd3A-1jl5A:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		9 MET A  46
LEU A  59
LEU A  62
LYS A  90
ILE A  91
THR A 170
HIS A 235
VAL A 277
TRP A 282
 None
 0.74A 2qd3A-1lbqA:
48.3		 2qd3A-1lbqA:
49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 MET A  46
LEU A  68
THR A 170
HIS A 235
VAL A 277
TRP A 282
 None
 0.83A 2qd3A-1lbqA:
48.3		 2qd3A-1lbqA:
49.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		5 LEU A 637
LEU A 680
ILE A 727
THR A 472
HIS A 735
 None
 1.11A 2qd3A-1lnsA:
2.3		 2qd3A-1lnsA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 LEU A 634
LEU A 419
LEU A 421
ILE A 496
THR A 484
 None
 1.25A 2qd3A-1mpxA:
1.8		 2qd3A-1mpxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A  83
LEU A 107
LEU A 129
ILE A  62
VAL A  72
 None
 1.09A 2qd3A-1oznA:
undetectable		 2qd3A-1oznA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A 112
LEU A 137
LEU A 159
ILE A  96
THR A 173
 None
 1.30A 2qd3A-1oznA:
undetectable		 2qd3A-1oznA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))
PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
PF13361
(UvrD_C) 		5 LEU D 617
LEU D 577
LEU D 564
ILE B 321
VAL B 299
 None
 1.26A 2qd3A-1qhhD:
undetectable		 2qd3A-1qhhD:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		5 LEU A 112
LEU A 132
LEU A 174
ILE A  90
THR A 148
 None
 1.11A 2qd3A-1u9cA:
undetectable		 2qd3A-1u9cA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		5 MET A  46
LEU A 117
LEU A 116
LEU A  68
ILE A 207
 None
 1.32A 2qd3A-1uz4A:
undetectable		 2qd3A-1uz4A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 LEU A  55
LEU A  43
ARG A  84
ILE A  86
VAL A  13
 None
 1.34A 2qd3A-1v43A:
undetectable		 2qd3A-1v43A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws0 PEPTIDE DEFORMYLASE
1

(Bacillus cereus) 		PF01327
(Pep_deformylase) 		5 LEU A  28
LEU A  31
LEU A   4
ARG A 113
ILE A  73
 None
 1.18A 2qd3A-1ws0A:
undetectable		 2qd3A-1ws0A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		5 LEU A 281
LEU A 328
LEU A 321
ILE A 283
TRP A  20
 None
 1.10A 2qd3A-1zbrA:
undetectable		 2qd3A-1zbrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 LEU A 103
LEU A 106
LEU A 220
ILE A  93
VAL A 183
 None
 1.14A 2qd3A-1zl6A:
undetectable		 2qd3A-1zl6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 LEU A 100
LEU A 103
LEU A 107
ILE A  65
TRP A   6
 None
 0.98A 2qd3A-2aaaA:
undetectable		 2qd3A-2aaaA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkj FLAVIN REDUCTASE

(Vibrio harveyi) 		PF00881
(Nitroreductase) 		5 LEU A  77
LEU A 157
LEU A 124
ARG A  50
ILE A  48
 None
 1.30A 2qd3A-2bkjA:
undetectable		 2qd3A-2bkjA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 LEU A 383
ARG A 379
ILE A 378
THR A 355
HIS A 299
 None
 1.00A 2qd3A-2e0xA:
undetectable		 2qd3A-2e0xA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 645
LEU A 479
THR A 470
VAL A 606
TRP A 609
 None
 1.28A 2qd3A-2f3oA:
undetectable		 2qd3A-2f3oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		6 LEU A 250
LEU A 247
LEU A 243
LYS A 278
THR A 156
VAL A 138
 None
 1.46A 2qd3A-2go4A:
undetectable		 2qd3A-2go4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti) 		PF00285
(Citrate_synt) 		5 LEU A 391
LEU A 267
ILE A 230
THR A 243
VAL A 370
 None
 1.10A 2qd3A-2h12A:
undetectable		 2qd3A-2h12A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 LEU A 420
LEU A 456
LEU A 274
VAL A 292
TRP A 289
 None
 1.29A 2qd3A-2h2qA:
2.1		 2qd3A-2h2qA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcz BETA-EXPANSIN 1A

(Zea mays) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		5 MET X  55
LEU X 108
LEU X 116
ILE X  63
TRP X  19
 None
 1.09A 2qd3A-2hczX:
undetectable		 2qd3A-2hczX:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00215
(OMPdecase) 		5 LEU A  84
LEU A 109
ARG A 270
ILE A 264
VAL A  71
 None
 1.19A 2qd3A-2p1fA:
undetectable		 2qd3A-2p1fA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		5 LEU A 307
LEU A  18
LEU A  15
ILE A 249
THR A  30
 None
 1.20A 2qd3A-2ppvA:
2.3		 2qd3A-2ppvA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		5 LEU A 273
LEU A 298
ARG A 459
ILE A 453
VAL A 260
 None
 1.19A 2qd3A-2qcmA:
undetectable		 2qd3A-2qcmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE

(Vibrio
parahaemolyticus) 		PF00282
(Pyridoxal_deC) 		5 LEU A 906
LEU A 902
ARG A 913
ILE A 915
THR A 893
 None
 1.32A 2qd3A-2qmaA:
undetectable		 2qd3A-2qmaA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 LEU A 927
LEU A 886
LEU A 972
ARG A 867
ILE A 843
 None
 1.33A 2qd3A-2xt6A:
5.0		 2qd3A-2xt6A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		5 LEU A 305
LEU A 306
LEU A 314
ILE A 332
VAL A 376
 None
 1.29A 2qd3A-2yeqA:
undetectable		 2qd3A-2yeqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 362
LEU A 389
LEU A 412
ILE A 341
VAL A 351
 None
None
None
PCJ  A   1 ( 4.6A)
PCJ  A   1 ( 4.0A)
 1.06A 2qd3A-2z81A:
undetectable		 2qd3A-2z81A:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		8 LEU A  89
LEU A  92
LEU A  98
ILE A 119
THR A 198
HIS A 263
VAL A 305
TRP A 310
 None
CHD  A   1 (-4.8A)
CHD  A   1 (-4.3A)
None
None
CHD  A   1 (-4.3A)
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
 0.67A 2qd3A-3aqiA:
59.6		 2qd3A-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 776
LEU A 786
ILE A 895
THR A 938
VAL A 902
 None
 1.28A 2qd3A-3dy5A:
undetectable		 2qd3A-3dy5A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 LEU A 257
LEU A 237
LEU A 216
ILE A 269
THR A 214
 None
 1.31A 2qd3A-3g06A:
undetectable		 2qd3A-3g06A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 LEU A 137
LEU A 138
LEU A 166
ILE A 465
THR A 157
 None
 1.32A 2qd3A-3geiA:
3.6		 2qd3A-3geiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  77
LEU A  52
ARG A  43
ILE A  42
TRP A  83
 None
 1.20A 2qd3A-3glqA:
4.6		 2qd3A-3glqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 LEU A  65
LEU A  62
LEU A 103
THR A  79
VAL A  31
 None
 1.11A 2qd3A-3h7uA:
undetectable		 2qd3A-3h7uA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0m DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1

(Schizosaccharomyces
pombe) 		PF00498
(FHA) 		5 MET A 233
LEU A 226
LEU A 243
ILE A 310
THR A 236
 None
 1.23A 2qd3A-3i0mA:
undetectable		 2qd3A-3i0mA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 U2 SMALL NUCLEAR
RIBONUCLEOPROTEIN A'

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		5 LEU j 108
LEU j 117
LEU j 144
ILE j  78
VAL j 124
 None
 1.17A 2qd3A-3jb9j:
undetectable		 2qd3A-3jb9j:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina) 		PF08718
(GLTP) 		5 MET A  67
LEU A 197
ILE A  88
THR A  49
VAL A  26
 None
MLY  A 198 ( 4.3A)
None
MLY  A  64 ( 4.3A)
None
 1.19A 2qd3A-3kv0A:
undetectable		 2qd3A-3kv0A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pet PUTATIVE ADHESIN

(Bacteroides
fragilis) 		PF10988
(DUF2807) 		5 LEU A 113
LEU A 135
LEU A 155
ILE A  47
VAL A 145
 None
 1.21A 2qd3A-3petA:
undetectable		 2qd3A-3petA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc0 SUGAR ISOMERASE

(Sinorhizobium
meliloti) 		PF01261
(AP_endonuc_2) 		5 LEU A 186
LEU A 157
LEU A 161
ARG A 234
ILE A 231
 None
 1.28A 2qd3A-3qc0A:
undetectable		 2qd3A-3qc0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 LEU A 152
LEU A 156
LEU A 160
THR A 226
VAL A 241
 None
 1.28A 2qd3A-3rv2A:
undetectable		 2qd3A-3rv2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A 290
LEU A 287
LEU A 284
ILE A 168
THR A  11
 None
None
None
None
GOL  A 392 (-4.2A)
 1.33A 2qd3A-3sqzA:
undetectable		 2qd3A-3sqzA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF07729
(FCD) 		5 LEU A  94
LEU A 193
LEU A 197
ILE A 101
TRP A 154
 None
 1.28A 2qd3A-3sxmA:
undetectable		 2qd3A-3sxmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		5 LEU A  74
ARG A  78
ILE A  80
HIS A 157
TRP A 463
 None
 1.32A 2qd3A-3t5tA:
5.0		 2qd3A-3t5tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		5 LEU A 115
LEU A 116
LEU A 153
ILE A  39
THR A 142
 None
 1.22A 2qd3A-3tqsA:
3.0		 2qd3A-3tqsA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		5 LEU A 773
LEU A 770
LEU A 762
ILE A 781
THR A 817
 None
 1.22A 2qd3A-3un9A:
undetectable		 2qd3A-3un9A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3via PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY B MEMBER 2

(Homo sapiens) 		PF00169
(PH) 		5 LEU A  79
LEU A  91
ILE A  58
THR A  16
VAL A  49
 None
 1.33A 2qd3A-3viaA:
undetectable		 2qd3A-3viaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wad GLYCOSYLTRANSFERASE

(Streptomyces
halstedii) 		PF06722
(DUF1205) 		5 LEU A 376
LEU A 256
ILE A 276
THR A 265
VAL A 299
 None
 1.19A 2qd3A-3wadA:
2.9		 2qd3A-3wadA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvs PUTATIVE
MONOOXYGENASE

(Streptomyces
sp. SN-593) 		PF00067
(p450) 		5 MET A 397
LEU A 374
LEU A 377
LEU A 258
ILE A 129
 None
 1.26A 2qd3A-3wvsA:
undetectable		 2qd3A-3wvsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zoq URACIL-DNA
GLYCOSYLASE

(Bacillus
subtilis) 		PF03167
(UDG) 		5 LEU A 122
LEU A  62
LEU A 163
ILE A 148
VAL A 159
 None
 1.30A 2qd3A-3zoqA:
2.4		 2qd3A-3zoqA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 LEU A  63
LEU A   8
LEU A  85
THR A 171
VAL A 117
 None
 1.25A 2qd3A-4acaA:
3.3		 2qd3A-4acaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster) 		no annotation 5 LEU A 599
LEU A 596
LEU A 593
ILE A 554
THR A 648
 None
 0.95A 2qd3A-4bwpA:
undetectable		 2qd3A-4bwpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 LEU C  30
LEU C  11
LEU C 142
ILE C  98
VAL C 138
 None
 1.33A 2qd3A-4fl4C:
undetectable		 2qd3A-4fl4C:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 LEU A 298
LEU A 319
LEU A 342
ILE A 278
VAL A 308
 None
 1.08A 2qd3A-4fs7A:
undetectable		 2qd3A-4fs7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4a MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Drosophila
melanogaster) 		PF13091
(PLDc_2) 		5 MET A 151
LEU A 109
LYS A 171
ILE A 111
VAL A  93
 None
 1.28A 2qd3A-4h4aA:
undetectable		 2qd3A-4h4aA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzc CYSE, SERINE
ACETYLTRANSFERASE

(Brucella
abortus) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		5 LEU A  51
LEU A  91
ILE A  23
THR A 123
VAL A  98
 None
 1.24A 2qd3A-4hzcA:
undetectable		 2qd3A-4hzcA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		5 LEU C 440
LEU C 443
LEU C 447
ILE C 374
VAL C 295
 None
 1.19A 2qd3A-4j16C:
2.1		 2qd3A-4j16C:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		5 LEU A 417
LEU A 413
LEU A 409
ILE A 254
VAL A 281
 None
 1.28A 2qd3A-4l9mA:
undetectable		 2qd3A-4l9mA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le1 TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR

(Bacillus
subtilis) 		PF00072
(Response_reg) 		5 LEU A  21
LEU A 109
ILE A   4
THR A  80
VAL A 116
 None
 1.33A 2qd3A-4le1A:
4.6		 2qd3A-4le1A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mag SIALIC ACID BINDING
PROTEIN

(Vibrio cholerae) 		PF03480
(DctP) 		5 LEU A  27
LEU A  37
LEU A  39
ILE A 232
VAL A 214
 None
 1.16A 2qd3A-4magA:
undetectable		 2qd3A-4magA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opw UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF10988
(DUF2807) 		5 LEU A 108
LEU A 130
LEU A 151
ILE A  44
VAL A 140
 None
 1.21A 2qd3A-4opwA:
undetectable		 2qd3A-4opwA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbc D-AMINO ACID
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01063
(Aminotran_4) 		5 LEU A  71
LEU A  74
LEU A  78
ILE A  96
THR A 119
 None
 1.25A 2qd3A-4pbcA:
undetectable		 2qd3A-4pbcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5q GLUTATHIONE
S-TRANSFERASE

(Dermatophagoides
pteronyssinus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 MET A 108
LEU A 129
LEU A 132
LEU A 136
THR A 105
 None
 1.18A 2qd3A-4q5qA:
undetectable		 2qd3A-4q5qA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rca SLIT AND NTRK-LIKE
PROTEIN 1

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU B 161
LEU B 184
LEU B 209
ILE B 145
VAL B 197
 None
 1.29A 2qd3A-4rcaB:
undetectable		 2qd3A-4rcaB:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A 478
LEU A 501
LEU A 526
ILE A 462
VAL A 514
 None
 1.32A 2qd3A-4rcwA:
undetectable		 2qd3A-4rcwA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		5 LEU A 251
LEU A 247
LEU A 211
ILE A  24
THR A 231
 None
 1.17A 2qd3A-4s38A:
undetectable		 2qd3A-4s38A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xup ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		5 LEU A 225
LEU A 228
LEU A 173
ILE A 297
THR A 332
 None
 1.34A 2qd3A-4xupA:
undetectable		 2qd3A-4xupA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE

(Homo sapiens) 		PF03414
(Glyco_transf_6) 		5 LEU A 280
LEU A 310
ARG A 188
ILE A 192
THR A 316
 None
None
48O  A 402 (-3.6A)
None
None
 1.21A 2qd3A-4y63A:
undetectable		 2qd3A-4y63A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		5 LEU B 315
LEU B 312
LEU B 308
THR B 344
VAL B 246
 None
 1.22A 2qd3A-4yg8B:
undetectable		 2qd3A-4yg8B:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)

(Homo sapiens) 		no annotation 5 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
 None
None
None
None
GOL  A 504 (-3.5A)
 1.15A 2qd3A-4z79A:
undetectable		 2qd3A-4z79A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)

(Homo sapiens) 		no annotation 5 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
 None
 1.13A 2qd3A-4z8gA:
undetectable		 2qd3A-4z8gA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		5 LEU G1420
LEU G1450
LEU G1467
ILE G1407
THR G1462
 None
 1.12A 2qd3A-4z94G:
2.4		 2qd3A-4z94G:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE

(Methanospirillum
hungatei) 		PF00485
(PRK) 		5 LEU A  87
LEU A  84
ARG A  91
ILE A  93
THR A 127
 None
 1.34A 2qd3A-5b3fA:
undetectable		 2qd3A-5b3fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm5 HYDROXYETHYLTHIAZOLE
KINASE

(Staphylococcus
aureus) 		PF02110
(HK) 		5 LEU A  30
LEU A 191
ARG A   8
ILE A   7
VAL A 217
 None
 1.28A 2qd3A-5cm5A:
3.2		 2qd3A-5cm5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 LEU A 357
LEU A 358
LEU A 373
ILE A  16
THR A 383
 None
 1.32A 2qd3A-5cqfA:
undetectable		 2qd3A-5cqfA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuk RULER PROTEIN

(Pseudomonas
aeruginosa) 		PF02120
(Flg_hook) 		5 LEU A 333
LEU A 329
LEU A 258
ILE A 310
VAL A 297
 None
 1.25A 2qd3A-5cukA:
undetectable		 2qd3A-5cukA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtp PROBABLE ENOYL-COA
HYDRATASE ECHA6

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 LEU A 104
LEU A  78
ARG A 111
ILE A  93
VAL A  89
 None
 1.08A 2qd3A-5dtpA:
undetectable		 2qd3A-5dtpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE

(Pseudomonas
veronii) 		PF00561
(Abhydrolase_1) 		5 LEU A 336
LEU A 340
LEU A 344
ILE A 162
VAL A  52
 None
 1.32A 2qd3A-5e4yA:
2.9		 2qd3A-5e4yA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 LEU A 294
LEU A 290
LEU A 284
ARG A 213
ILE A 210
 None
 1.17A 2qd3A-5ecoA:
undetectable		 2qd3A-5ecoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 LEU A 196
LEU A 197
LEU A 212
ILE A  64
VAL A 102
 None
 1.15A 2qd3A-5f56A:
4.6		 2qd3A-5f56A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		5 LEU A 318
LEU A 332
LEU A 374
ARG A 270
THR A 371
 None
 1.18A 2qd3A-5fifA:
undetectable		 2qd3A-5fifA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 LEU A 428
LEU A 431
LEU A 435
ILE A 345
THR A 387
 None
 0.87A 2qd3A-5g4iA:
undetectable		 2qd3A-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 LEU A 428
LEU A 431
LEU A 435
THR A 387
VAL A 362
 None
 1.12A 2qd3A-5g4iA:
undetectable		 2qd3A-5g4iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1

(Homo sapiens) 		PF01273
(LBP_BPI_CETP) 		5 LEU A  55
LEU A 118
ILE A 242
THR A 160
VAL A 253
 None
 1.30A 2qd3A-5i7kA:
undetectable		 2qd3A-5i7kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7

(Zea mays) 		PF00248
(Aldo_ket_red) 		5 LEU A  62
LEU A  59
LEU A 100
THR A  76
VAL A  28
 None
 1.19A 2qd3A-5jh1A:
undetectable		 2qd3A-5jh1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpq ES7

(Chaetomium
thermophilum) 		PF01798
(Nop) 		5 LEU s  80
LEU s  84
LEU s  88
ILE s  40
VAL s  45
 None
 1.28A 2qd3A-5jpqs:
undetectable		 2qd3A-5jpqs:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 5 LEU A  83
LEU A 107
LEU A 129
ILE A  62
VAL A  72
 None
 1.07A 2qd3A-5o0lA:
undetectable		 2qd3A-5o0lA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 5 LEU A 112
LEU A 137
LEU A 159
ILE A  96
THR A 173
 None
 1.30A 2qd3A-5o0lA:
undetectable		 2qd3A-5o0lA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujw TRIOSEPHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00121
(TIM) 		5 LEU A 152
LEU A 157
LEU A 192
ILE A 115
VAL A 123
 None
 1.33A 2qd3A-5ujwA:
undetectable		 2qd3A-5ujwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uu6 NADPH-FLAVIN
OXIDOREDUCTASE

(Vibrio
parahaemolyticus) 		PF00881
(Nitroreductase) 		5 LEU A  77
LEU A 157
LEU A 124
ARG A  50
ILE A  48
 None
 1.29A 2qd3A-5uu6A:
undetectable		 2qd3A-5uu6A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 5 LEU A 284
LEU A  88
ILE A   5
VAL A  21
TRP A  20
 None
 1.31A 2qd3A-5vqdA:
2.8		 2qd3A-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 5 MET A 315
LEU A  88
ILE A   5
VAL A  21
TRP A  20
 None
 1.32A 2qd3A-5vqdA:
2.8		 2qd3A-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7c ACYLOXYACYL
HYDROLASE
ACYLOXYACYL
HYDROLASE

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 LEU C 288
LEU A  73
ILE C 270
THR A  82
VAL A  50
 None
None
FTT  C 611 (-3.9A)
None
FTT  C 611 ( 4.3A)
 1.22A 2qd3A-5w7cC:
2.5		 2qd3A-5w7cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xne -

(-) 		no annotation 5 LEU B  32
LEU B  31
LEU B  59
ILE B 247
HIS B 193
 None
None
None
None
ZN  B 301 (-3.4A)
 1.22A 2qd3A-5xneB:
undetectable		 2qd3A-5xneB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 436
LEU A 431
ILE A 409
THR A 378
VAL A 397
 None
 1.21A 2qd3A-5yxgA:
undetectable		 2qd3A-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 436
LEU A 431
ILE A 409
THR A 378
VAL A 397
 None
 1.23A 2qd3A-5z24A:
undetectable		 2qd3A-5z24A:
undetectable