SIMILAR PATTERNS OF AMINO ACIDS FOR 2QD2_A_CHDA426

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)

(Ochrobactrum
anthropi) 		PF03576
(Peptidase_S58) 		4 LEU A 259
PRO A 260
LEU A 261
ARG A 268
 None
 1.42A 2qd2A-1b65A:
undetectable		 2qd2A-1b65A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		4 LEU A  93
PRO A 127
LEU A 157
ARG A 164
 None
 1.47A 2qd2A-1d2rA:
undetectable		 2qd2A-1d2rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 106
PRO A 107
LEU A 110
ARG A 117
 NAD  A 500 (-3.9A)
NAD  A 500 (-4.5A)
None
None
 1.27A 2qd2A-1evjA:
3.5		 2qd2A-1evjA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 158
PRO A 159
LEU A 162
ARG A 169
 NDP  A 500 (-4.1A)
NDP  A 500 (-4.1A)
None
None
 1.23A 2qd2A-1h6dA:
undetectable		 2qd2A-1h6dA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 LEU A 282
PRO A 283
LEU A 285
ARG A 253
 None
 1.48A 2qd2A-1hl2A:
undetectable		 2qd2A-1hl2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 LEU A 304
PRO A 275
LEU A 291
ARG A 298
 None
 1.45A 2qd2A-1kczA:
undetectable		 2qd2A-1kczA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 LEU A  33
PRO A  37
LEU A  45
ARG A   6
 None
 1.49A 2qd2A-1l5jA:
undetectable		 2qd2A-1l5jA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF02358
(Trehalose_PPase) 		4 LEU A  58
PRO A  57
LEU A  29
ARG A 216
 None
 1.49A 2qd2A-1u02A:
2.1		 2qd2A-1u02A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 LEU A 262
PRO A 259
LEU A  37
ARG A 269
 None
 1.43A 2qd2A-1vcnA:
2.7		 2qd2A-1vcnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpq HYPOTHETICAL PROTEIN
TM1631

(Thermotoga
maritima) 		PF01904
(DUF72) 		4 LEU A 173
PRO A 174
LEU A 176
ARG A 207
 None
None
None
SO4  A 263 (-2.8A)
 1.49A 2qd2A-1vpqA:
undetectable		 2qd2A-1vpqA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqj INSULIN-LIKE GROWTH
FACTOR BINDING
PROTEIN 4

(Homo sapiens) 		PF00219
(IGFBP) 		4 LEU B  69
PRO B  68
LEU B  72
ARG B  58
 None
 1.48A 2qd2A-1wqjB:
undetectable		 2qd2A-1wqjB:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 LEU A 359
PRO A 409
LEU A 337
ARG A 338
 None
 1.49A 2qd2A-1z3zA:
2.6		 2qd2A-1z3zA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		4 LEU A 430
PRO A 429
LEU A 433
ARG A 377
 None
 1.38A 2qd2A-2braA:
undetectable		 2qd2A-2braA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A1401 (-3.9A)
NAD  A1401 (-3.1A)
 1.29A 2qd2A-2dfvA:
2.5		 2qd2A-2dfvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsq INSULIN-LIKE GROWTH
FACTOR-BINDING
PROTEIN 4

(Homo sapiens) 		no annotation 4 LEU B  69
PRO B  68
LEU B  72
ARG B  58
 None
 1.30A 2qd2A-2dsqB:
undetectable		 2qd2A-2dsqB:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2duy COMPETENCE PROTEIN
COMEA-RELATED
PROTEIN

(Thermus
thermophilus) 		PF12836
(HHH_3) 		4 LEU A  66
PRO A  63
LEU A  56
ARG A  51
 None
 1.11A 2qd2A-2duyA:
undetectable		 2qd2A-2duyA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebj PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermus
thermophilus) 		PF01470
(Peptidase_C15) 		4 LEU A  39
PRO A  40
LEU A  46
ARG A 149
 None
 1.36A 2qd2A-2ebjA:
4.9		 2qd2A-2ebjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A  51
PRO A  50
LEU A  54
ARG A 160
 None
 1.46A 2qd2A-2f9gA:
undetectable		 2qd2A-2f9gA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 LEU A 572
PRO A 573
LEU A 557
ARG A 568
 None
 1.41A 2qd2A-2g3nA:
undetectable		 2qd2A-2g3nA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		4 LEU A 215
PRO A 216
LEU A 217
ARG A 178
 None
 1.24A 2qd2A-2i62A:
undetectable		 2qd2A-2i62A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6p SB(V)-AS(V)
REDUCTASE

(Leishmania
major) 		PF00581
(Rhodanese) 		4 LEU A  12
PRO A   9
LEU A 106
ARG A  31
 None
 1.41A 2qd2A-2j6pA:
3.6		 2qd2A-2j6pA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 LEU A 402
PRO A 403
LEU A 404
ARG A 271
 None
 1.35A 2qd2A-2m56A:
undetectable		 2qd2A-2m56A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og9 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Polaromonas sp.
JS666) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 285
PRO A 287
LEU A 312
ARG A 330
 None
 1.36A 2qd2A-2og9A:
undetectable		 2qd2A-2og9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE

(Thermobifida
fusca) 		PF13378
(MR_MLE_C) 		4 LEU A 271
PRO A 269
LEU A 258
ARG A  13
 None
 1.15A 2qd2A-2opjA:
undetectable		 2qd2A-2opjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		4 LEU X 293
PRO X 291
LEU X 143
ARG X 250
 None
 1.30A 2qd2A-2p4hX:
2.4		 2qd2A-2p4hX:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A1522
PRO A1521
LEU A1564
ARG A1566
 None
 1.32A 2qd2A-2pffA:
3.1		 2qd2A-2pffA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppq HOMOSERINE KINASE

(Agrobacterium
fabrum) 		PF01636
(APH) 		4 LEU A 268
PRO A 182
LEU A 219
ARG A 255
 None
 1.50A 2qd2A-2ppqA:
undetectable		 2qd2A-2ppqA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		4 LEU A  62
PRO A  61
LEU A  41
ARG A  43
 None
 1.16A 2qd2A-2qc3A:
undetectable		 2qd2A-2qc3A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 LEU A 117
PRO A 116
LEU A 251
ARG A 253
 None
 1.37A 2qd2A-2qkxA:
2.4		 2qd2A-2qkxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 901
PRO A 844
LEU A 843
ARG A 789
 None
 1.32A 2qd2A-2qobA:
undetectable		 2qd2A-2qobA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 130
PRO A 131
LEU A 112
ARG A 118
 None
 1.46A 2qd2A-2uxtA:
undetectable		 2qd2A-2uxtA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwl 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF01128
(IspD) 		4 LEU A 211
PRO A 208
LEU A  16
ARG A  20
 None
 1.41A 2qd2A-2xwlA:
2.9		 2qd2A-2xwlA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		4 LEU A  56
PRO A  57
LEU A  78
ARG A 125
 None
 1.38A 2qd2A-3aytA:
undetectable		 2qd2A-3aytA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		PF00073
(Rhv) 		4 LEU C  90
PRO C  86
LEU C 105
ARG C 273
 None
 1.42A 2qd2A-3cjiC:
undetectable		 2qd2A-3cjiC:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		4 LEU A 179
PRO A 180
LEU A 183
ARG A  15
 None
 1.44A 2qd2A-3egeA:
2.2		 2qd2A-3egeA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4s PUTATIVE
UNCHARACTERIZED
PROTEIN

(Wolbachia
endosymbiont of
Drosophila
melanogaster) 		PF13462
(Thioredoxin_4) 		4 LEU A  76
PRO A  37
LEU A  33
ARG A  80
 None
 1.32A 2qd2A-3f4sA:
undetectable		 2qd2A-3f4sA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C LIGHT
CHAIN

(Homo sapiens) 		PF00008
(EGF)
PF14670
(FXa_inhibition) 		4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
 None
 1.46A 2qd2A-3f6uL:
undetectable		 2qd2A-3f6uL:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3t VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF09359
(VTC) 		4 LEU A 219
PRO A 220
LEU A 366
ARG A 371
 None
 1.46A 2qd2A-3g3tA:
undetectable		 2qd2A-3g3tA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A 500 (-4.1A)
NAD  A 500 (-2.6A)
 1.44A 2qd2A-3gfbA:
3.5		 2qd2A-3gfbA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvz UNCHARACTERIZED
PROTEIN CV2077

(Chromobacterium
violaceum) 		PF03417
(AAT) 		4 LEU A  99
PRO A 100
LEU A 103
ARG A 160
 None
 1.25A 2qd2A-3gvzA:
undetectable		 2qd2A-3gvzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A  85
PRO A  86
LEU A  87
ARG A 166
 None
 1.46A 2qd2A-3hz6A:
undetectable		 2qd2A-3hz6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 LEU A  42
PRO A  43
LEU A  47
ARG A  24
 None
 0.99A 2qd2A-3i2tA:
undetectable		 2qd2A-3i2tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		4 LEU A 289
PRO A 290
LEU A 261
ARG A 233
 None
 1.41A 2qd2A-3kjxA:
4.4		 2qd2A-3kjxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 LEU A  61
PRO A  62
LEU A  48
ARG A 231
 None
 1.27A 2qd2A-3p2mA:
3.6		 2qd2A-3p2mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qit POLYKETIDE SYNTHASE

(Moorea
producens) 		PF00561
(Abhydrolase_1) 		4 LEU A  76
PRO A 214
LEU A  79
ARG A 113
 None
 1.34A 2qd2A-3qitA:
3.4		 2qd2A-3qitA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv2 S-ADENOSYLMETHIONINE
SYNTHASE

(Mycobacterium
marinum) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 LEU A 236
PRO A 193
LEU A 152
ARG A 159
 None
 1.45A 2qd2A-3rv2A:
undetectable		 2qd2A-3rv2A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s06 MOTILITY PROTEIN B

(Helicobacter
pylori) 		PF00691
(OmpA) 		4 LEU A 119
PRO A 120
LEU A 123
ARG A 143
 None
 0.82A 2qd2A-3s06A:
undetectable		 2qd2A-3s06A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT

(Cryptococcus
neoformans) 		PF01239
(PPTA) 		4 LEU A 253
PRO A 250
LEU A 249
ARG A 303
 None
 1.40A 2qd2A-3sfyA:
undetectable		 2qd2A-3sfyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 LEU A 196
PRO A 197
LEU A 216
ARG A 257
 None
 1.46A 2qd2A-3ua4A:
2.7		 2qd2A-3ua4A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		4 LEU A 156
PRO A 157
LEU A 130
ARG A 307
 None
 1.13A 2qd2A-4c1nA:
3.8		 2qd2A-4c1nA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		4 LEU A 337
PRO A 338
LEU A 340
ARG A 325
 None
 1.44A 2qd2A-4e7wA:
undetectable		 2qd2A-4e7wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 LEU A  53
PRO A  52
LEU A 385
ARG A 352
 None
 1.38A 2qd2A-4g3jA:
undetectable		 2qd2A-4g3jA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2g KLTH0A00704P

(Lachancea
thermotolerans) 		PF10033
(ATG13) 		4 LEU A 225
PRO A 226
LEU A 229
ARG A 118
 None
None
None
SO4  A 301 (-2.6A)
 1.19A 2qd2A-4j2gA:
undetectable		 2qd2A-4j2gA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8b COATOMER ALPHA
SUBUNIT

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 LEU A 224
PRO A 225
LEU A 226
ARG A 288
 None
 1.07A 2qd2A-4j8bA:
undetectable		 2qd2A-4j8bA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		4 LEU A 309
PRO A 310
LEU A 196
ARG A 198
 None
 1.49A 2qd2A-4ke4A:
undetectable		 2qd2A-4ke4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9w ARA H 8 ALLERGEN

(Arachis
hypogaea) 		PF00407
(Bet_v_1) 		4 LEU A 103
PRO A  16
LEU A  19
ARG A 144
 None
 1.23A 2qd2A-4m9wA:
undetectable		 2qd2A-4m9wA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf1 ACETYLGLUTAMATE
KINASE

(Xylella
fastidiosa) 		PF04768
(NAT) 		4 LEU A 344
PRO A 351
LEU A 330
ARG A 295
 None
 1.40A 2qd2A-4nf1A:
undetectable		 2qd2A-4nf1A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 LEU A 241
PRO A 240
LEU A 256
ARG A 293
 None
 1.39A 2qd2A-4o1oA:
undetectable		 2qd2A-4o1oA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pba UNCHARACTERIZED
PROTEIN ABASI

(Acinetobacter
baumannii) 		no annotation 4 LEU B 222
PRO B 266
LEU B 214
ARG B 210
 None
 1.38A 2qd2A-4pbaB:
undetectable		 2qd2A-4pbaB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 LEU A 388
PRO A 383
LEU A 386
ARG A 399
 None
 1.42A 2qd2A-4pzvA:
undetectable		 2qd2A-4pzvA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		4 LEU A 430
PRO A 429
LEU A 433
ARG A 377
 None
 1.40A 2qd2A-4txkA:
undetectable		 2qd2A-4txkA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU B 246
PRO B 242
LEU B 291
ARG B 296
 None
 1.38A 2qd2A-4tyhB:
undetectable		 2qd2A-4tyhB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.36A 2qd2A-4zasA:
undetectable		 2qd2A-4zasA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 LEU A 362
PRO A 364
LEU A 306
ARG A 325
 None
 1.23A 2qd2A-4zdkA:
4.7		 2qd2A-4zdkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		4 LEU A 198
PRO A 195
LEU A 233
ARG A 240
 None
 1.25A 2qd2A-4zm4A:
2.4		 2qd2A-4zm4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f HUMAN SAFFOLD
VIRUS-3 VP1
HUMAN SAFFOLD
VIRUS-3 VP2

(Cardiovirus B;
Cardiovirus B) 		no annotation
PF00073
(Rhv) 		4 LEU A  73
PRO A  74
LEU C 182
ARG A 252
 None
 1.45A 2qd2A-5a8fA:
undetectable		 2qd2A-5a8fA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b01 MOEN5

(Streptomyces
viridosporus) 		no annotation 4 LEU A  59
PRO A  39
LEU A  42
ARG A 171
 None
 1.27A 2qd2A-5b01A:
undetectable		 2qd2A-5b01A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0l MOEN5,DNA-BINDING
PROTEIN 7D

(Sulfolobus
solfataricus;
Streptomyces
viridosporus) 		no annotation 4 LEU A  59
PRO A  39
LEU A  42
ARG A 171
 None
 1.35A 2qd2A-5b0lA:
undetectable		 2qd2A-5b0lA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 4 LEU A 368
PRO A 367
LEU A 363
ARG A 312
 None
CL  A1705 ( 3.9A)
None
None
 1.42A 2qd2A-5b2oA:
2.8		 2qd2A-5b2oA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brl STAR-RELATED LIPID
TRANSFER PROTEIN 4

(Mus musculus) 		PF01852
(START) 		4 LEU A  93
PRO A  90
LEU A 102
ARG A 116
 None
 1.18A 2qd2A-5brlA:
undetectable		 2qd2A-5brlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 LEU A 219
PRO A 220
LEU A 223
ARG A 263
 None
 0.82A 2qd2A-5bzaA:
3.2		 2qd2A-5bzaA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg9 TET-LIKE DIOXYGENASE

(Naegleria
gruberi) 		no annotation 4 LEU A 196
PRO A 209
LEU A 193
ARG A 188
 None
 1.48A 2qd2A-5cg9A:
undetectable		 2qd2A-5cg9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 LEU A 382
PRO A 418
LEU A 390
ARG A 447
 None
EDO  A 506 (-4.1A)
None
None
 1.38A 2qd2A-5h7nA:
undetectable		 2qd2A-5h7nA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iig VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF03105
(SPX)
PF09359
(VTC) 		4 LEU A 219
PRO A 220
LEU A 366
ARG A 371
 None
 1.47A 2qd2A-5iigA:
undetectable		 2qd2A-5iigA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		4 LEU A 684
PRO A 683
LEU A 729
ARG A 736
 None
 1.48A 2qd2A-5ikzA:
undetectable		 2qd2A-5ikzA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 LEU B 459
PRO B 460
LEU B 461
ARG B 661
 None
 1.43A 2qd2A-5iz5B:
4.7		 2qd2A-5iz5B:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5e CYTOKINE RECEPTOR
COMMON SUBUNIT GAMMA

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		4 LEU C  35
PRO C  36
LEU C  63
ARG C 114
 None
 1.16A 2qd2A-5m5eC:
undetectable		 2qd2A-5m5eC:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 4 LEU A 305
PRO A 306
LEU A 239
ARG A 246
 GOL  A 504 (-3.6A)
None
None
None
 1.26A 2qd2A-5ns8A:
undetectable		 2qd2A-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 4 LEU A 613
PRO A 614
LEU A 597
ARG A 609
 None
 1.42A 2qd2A-5ohsA:
undetectable		 2qd2A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opg ENVELOPE
GLYCOPROTEIN GN

(Hantaan
orthohantavirus) 		PF01567
(Hanta_G1) 		4 LEU A  46
PRO A 140
LEU A 161
ARG A 165
 None
 1.24A 2qd2A-5opgA:
undetectable		 2qd2A-5opgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		4 LEU A 511
PRO A 527
LEU A 536
ARG A 535
 None
 1.45A 2qd2A-5wu6A:
undetectable		 2qd2A-5wu6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 LEU A 410
PRO A 411
LEU A 414
ARG A 351
 None
 1.02A 2qd2A-5ww1A:
undetectable		 2qd2A-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze8 CYTOCHROME C552

(Thermochromatium
tepidum) 		no annotation 4 LEU A 418
PRO A 419
LEU A 422
ARG A 319
 None
None
None
HEM  A 502 ( 2.8A)
 1.26A 2qd2A-5ze8A:
undetectable		 2qd2A-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 4 LEU A 108
PRO A 109
LEU A 187
ARG A 155
 None
 1.31A 2qd2A-6bs7A:
undetectable		 2qd2A-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn0 -

(-) 		no annotation 4 LEU A  24
PRO A  21
LEU A  23
ARG A  73
 None
 1.47A 2qd2A-6fn0A:
3.0		 2qd2A-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 LEU A 435
PRO A 439
LEU A 432
ARG A 419
 None
 1.43A 2qd2A-6g9oA:
undetectable		 2qd2A-6g9oA:
undetectable