SIMILAR PATTERNS OF AMINO ACIDS FOR 2QB4_A_DSMA802_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a3q | PROTEIN (NUCLEARFACTOR KAPPA-B P52) (Homo sapiens) |
PF00554(RHD_DNA_bind)PF16179(RHD_dimer) | 4 | ILE A 230SER A 318ARG A 261PHE A 289 | None | 0.82A | 2qb4A-1a3qA:2.0 | 2qb4A-1a3qA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bf5 | SIGNAL TRANSDUCERAND ACTIVATOR OFTRANSCRIPTION1-ALPHA/BETA (Homo sapiens) |
PF00017(SH2)PF01017(STAT_alpha)PF02864(STAT_bind) | 4 | ILE A 578ARG A 602PHE A 581PHE A 506 | None | 1.10A | 2qb4A-1bf5A:0.0 | 2qb4A-1bf5A:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fs5 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Escherichiacoli) |
PF01182(Glucosamine_iso) | 4 | ILE A 20PHE A 63ILE A 99PHE A 93 | None | 1.09A | 2qb4A-1fs5A:0.0 | 2qb4A-1fs5A:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htw | HI0065 (Haemophilusinfluenzae) |
PF02367(TsaE) | 4 | ILE A 140PHE A 156ILE A 152PHE A 21 | None | 1.22A | 2qb4A-1htwA:undetectable | 2qb4A-1htwA:13.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j26 | IMMATURE COLONCARCINOMA TRANSCRIPT1 (Mus musculus) |
PF00472(RF-1) | 4 | ILE A 17SER A 14ILE A 64PHE A 48 | None | 0.88A | 2qb4A-1j26A:undetectable | 2qb4A-1j26A:12.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3u | ASPARTASE (Bacillus sp.YM55-1) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 4 | ILE A 291ARG A 296ILE A 309PHE A 201 | None | 1.12A | 2qb4A-1j3uA:0.8 | 2qb4A-1j3uA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jb7 | TELOMERE-BINDINGPROTEIN BETA SUBUNIT (Sterkiella nova) |
PF07404(TEBP_beta) | 4 | ILE B 90PHE B 63ILE B 80PHE B 50 | None | 1.08A | 2qb4A-1jb7B:undetectable | 2qb4A-1jb7B:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ne7 | GLUCOSAMINE-6-PHOSPHATE ISOMERASE (Homo sapiens) |
PF01182(Glucosamine_iso) | 4 | ILE A 20PHE A 63ILE A 99PHE A 93 | None | 1.06A | 2qb4A-1ne7A:0.0 | 2qb4A-1ne7A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5t | TRYPTOPHANYL-TRNASYNTHETASE (Homo sapiens) |
PF00579(tRNA-synt_1b) | 4 | ILE A 359PHE A 340ILE A 175PHE A 406 | None | 1.13A | 2qb4A-1o5tA:0.0 | 2qb4A-1o5tA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ox4 | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASEHISHF (Saccharomycescerevisiae) |
PF00117(GATase)PF00977(His_biosynth) | 4 | ILE B 152SER B 110PHE B 107ILE B 105 | None | 1.21A | 2qb4A-1ox4B:0.0 | 2qb4A-1ox4B:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oyz | HYPOTHETICAL PROTEINYIBA (Escherichiacoli) |
PF13646(HEAT_2) | 4 | ILE A 214ARG A 194PHE A 197ILE A 193 | None | 0.75A | 2qb4A-1oyzA:0.0 | 2qb4A-1oyzA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 4 | ILE A 30ARG A 44PHE A 45PHE A 239 | None | 0.99A | 2qb4A-1pegA:undetectable | 2qb4A-1pegA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pp1 | P40 NUCLEOPROTEIN (Borna diseasevirus) |
PF06407(BDV_P40) | 4 | ILE X 83PHE X 206ILE X 197PHE X 90 | None | 1.24A | 2qb4A-1pp1X:0.0 | 2qb4A-1pp1X:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6u | TRYPTOPHANYL-TRNASYNTHETASE (Homo sapiens) |
PF00579(tRNA-synt_1b) | 4 | ILE A 359PHE A 340ILE A 175PHE A 406 | NoneNoneTYM A 501 ( 4.5A)None | 1.02A | 2qb4A-1r6uA:undetectable | 2qb4A-1r6uA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rw2 | ATP-DEPENDENT DNAHELICASE II, 80 KDASUBUNIT (Homo sapiens) |
PF08785(Ku_PK_bind) | 4 | ILE A 81ARG A 96PHE A 97ILE A 128 | None | 1.03A | 2qb4A-1rw2A:undetectable | 2qb4A-1rw2A:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1svc | PROTEIN (NUCLEARFACTOR KAPPA-B(NF-KB)) (Homo sapiens) |
PF00554(RHD_DNA_bind)PF16179(RHD_dimer) | 4 | ILE P 253SER P 343ARG P 284PHE P 314 | None | 0.93A | 2qb4A-1svcP:undetectable | 2qb4A-1svcP:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v33 | DNA PRIMASE SMALLSUBUNIT (Pyrococcushorikoshii) |
PF01896(DNA_primase_S) | 4 | SER A 271ARG A 216ILE A 124PHE A 279 | None | 1.25A | 2qb4A-1v33A:undetectable | 2qb4A-1v33A:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcz | RNASE NGR3 (Nicotianaglutinosa) |
PF00445(Ribonuclease_T2) | 4 | ILE A 147ARG A 116PHE A 36PHE A 201 | None | 1.15A | 2qb4A-1vczA:undetectable | 2qb4A-1vczA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpm | ACYL-COA HYDROLASE (Bacillushalodurans) |
PF03061(4HBT) | 4 | ILE A 38ARG A 16ILE A 29PHE A 64 | None | 1.04A | 2qb4A-1vpmA:undetectable | 2qb4A-1vpmA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w33 | BBCRASP-1 (Borreliellaburgdorferi) |
PF05714(Borrelia_lipo_1) | 4 | ILE A 163SER A 167ILE A 139PHE A 104 | None | 1.11A | 2qb4A-1w33A:undetectable | 2qb4A-1w33A:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wko | TERMINAL FLOWER 1PROTEIN (Arabidopsisthaliana) |
PF01161(PBP) | 4 | ARG A 143PHE A 146ILE A 140PHE A 151 | None | 1.15A | 2qb4A-1wkoA:undetectable | 2qb4A-1wkoA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wzx | COG3291: FOG: PKDREPEAT (Ruminiclostridiumthermocellum) |
no annotation | 4 | ILE A 123PHE A 172ILE A 175PHE A 160 | None | 1.06A | 2qb4A-1wzxA:undetectable | 2qb4A-1wzxA:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkt | FATTY ACID SYNTHASE (Homo sapiens) |
PF00975(Thioesterase) | 4 | ARG A2220PHE A2375ILE A2404PHE A2371 | None | 1.16A | 2qb4A-1xktA:undetectable | 2qb4A-1xktA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yz6 | PROBABLE TRANSLATIONINITIATION FACTOR 2ALPHA SUBUNIT (Pyrococcusabyssi) |
PF00575(S1)PF07541(EIF_2_alpha) | 4 | ILE A 251ARG A 201ILE A 243PHE A 182 | None | 1.00A | 2qb4A-1yz6A:undetectable | 2qb4A-1yz6A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvt | BETA-1,4-MANNANASE (Cellulomonasfimi) |
PF02156(Glyco_hydro_26) | 4 | ILE A 168SER A 158PHE A 94ILE A 74 | None | 0.81A | 2qb4A-2bvtA:undetectable | 2qb4A-2bvtA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2db1 | HETEROGENEOUSNUCLEARRIBONUCLEOPROTEIN F (Mus musculus) |
PF00076(RRM_1) | 4 | ILE A 46SER A 54ARG A 81ILE A 83 | None | 1.22A | 2qb4A-2db1A:undetectable | 2qb4A-2db1A:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f91 | HEPATOPANCREASTRYPSIN (Astacusleptodactylus) |
PF00089(Trypsin) | 4 | ILE A 88SER A 104PHE A 33ILE A 66 | None | 1.04A | 2qb4A-2f91A:undetectable | 2qb4A-2f91A:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fji | EXOCYST COMPLEXCOMPONENT SEC6 (Saccharomycescerevisiae) |
PF06046(Sec6) | 4 | ILE 1 546SER 1 549PHE 1 652ILE 1 601 | None | 1.11A | 2qb4A-2fji1:undetectable | 2qb4A-2fji1:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fr1 | ERYTHROMYCINSYNTHASE, ERYAI (Saccharopolysporaerythraea) |
PF08659(KR) | 4 | ARG A1890ARG A1893PHE A1894PHE A1805 | None | 1.14A | 2qb4A-2fr1A:undetectable | 2qb4A-2fr1A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fr1 | ERYTHROMYCINSYNTHASE, ERYAI (Saccharopolysporaerythraea) |
PF08659(KR) | 4 | ILE A1887ARG A1890ARG A1893PHE A1894 | None | 1.07A | 2qb4A-2fr1A:undetectable | 2qb4A-2fr1A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g2q | GLUTAREDOXIN-2 (Vaccinia virus) |
PF05768(DUF836) | 4 | ILE A 88SER A 91PHE A 94ILE A 15 | None | 1.11A | 2qb4A-2g2qA:undetectable | 2qb4A-2g2qA:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gaf | POLY(A) POLYMERASECATALYTIC SUBUNIT (Vaccinia virus) |
PF03296(Pox_polyA_pol)PF12629(Pox_polyA_pol_C)PF12630(Pox_polyA_pol_N) | 4 | ILE D 205SER D 254PHE D 213ILE D 111 | None | 1.10A | 2qb4A-2gafD:undetectable | 2qb4A-2gafD:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i7n | PANTOTHENATE KINASE1 (Homo sapiens) |
PF03630(Fumble) | 4 | ILE A 243PHE A 312ILE A 310PHE A 320 | None | 1.06A | 2qb4A-2i7nA:undetectable | 2qb4A-2i7nA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2inv | INSULINFRUCTOTRANSFERASE (Bacillus sp.snu-7) |
no annotation | 4 | ILE A 100PHE A 165ILE A 204PHE A 183 | None | 1.15A | 2qb4A-2invA:undetectable | 2qb4A-2invA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kr5 | AFLATOXINBIOSYNTHESISPOLYKETIDE SYNTHASE (Aspergillusparasiticus) |
PF00550(PP-binding) | 4 | ILE A 26ARG A 53ILE A 50PHE A 37 | None | 1.16A | 2qb4A-2kr5A:undetectable | 2qb4A-2kr5A:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og2 | PUTATIVE SIGNALRECOGNITION PARTICLERECEPTOR (Arabidopsisthaliana) |
PF00448(SRP54)PF02881(SRP54_N) | 4 | ILE A 79SER A 105PHE A 327ILE A 326 | None | 1.01A | 2qb4A-2og2A:undetectable | 2qb4A-2og2A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v26 | MYOSIN VI (Sus scrofa) |
PF00063(Myosin_head) | 4 | ILE A 247PHE A 338ILE A 259PHE A 317 | None | 1.24A | 2qb4A-2v26A:1.4 | 2qb4A-2v26A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v26 | MYOSIN VI (Sus scrofa) |
PF00063(Myosin_head) | 4 | SER A 150ARG A 667PHE A 665ILE A 488 | None | 1.04A | 2qb4A-2v26A:1.4 | 2qb4A-2v26A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v5e | GDNF FAMILY RECEPTORALPHA-1 (Rattusnorvegicus) |
PF02351(GDNF) | 4 | ILE A 293ARG A 225PHE A 213ILE A 342 | None | 1.22A | 2qb4A-2v5eA:undetectable | 2qb4A-2v5eA:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7y | CHAPERONE PROTEINDNAK (Geobacilluskaustophilus) |
PF00012(HSP70) | 4 | ILE A 370ARG A 425PHE A 426ILE A 468 | None | 0.95A | 2qb4A-2v7yA:undetectable | 2qb4A-2v7yA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wp0 | HOBA (Helicobacterpylori) |
PF12163(HobA) | 4 | ILE A 65PHE A 166ILE A 37PHE A 134 | None | 1.20A | 2qb4A-2wp0A:undetectable | 2qb4A-2wp0A:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x25 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEA (Homo sapiens) |
PF00160(Pro_isomerase) | 4 | SER B 40PHE B 112ILE B 114PHE B 53 | None | 1.14A | 2qb4A-2x25B:undetectable | 2qb4A-2x25B:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yqh | UDP-N-ACETYLGLUCOSAMINEPYROPHOSPHORYLASE (Candidaalbicans) |
PF01704(UDPGP) | 4 | ILE A 9SER A 12PHE A 22PHE A 36 | None | 1.16A | 2qb4A-2yqhA:undetectable | 2qb4A-2yqhA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzj | GLUCURONAN LYASE A (Trichodermareesei) |
PF14099(Polysacc_lyase) | 4 | ILE A 114ARG A 75PHE A 74PHE A 172 | NoneCIT A 240 (-2.8A)NoneNone | 0.90A | 2qb4A-2zzjA:undetectable | 2qb4A-2zzjA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3agb | RED CHLOROPHYLLCATABOLITEREDUCTASE,CHLOROPLASTIC (Arabidopsisthaliana) |
PF06405(RCC_reductase) | 4 | ILE A 135SER A 137ILE A 312PHE A 296 | None | 1.15A | 2qb4A-3agbA:undetectable | 2qb4A-3agbA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2r | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I) | 4 | ILE A 599ARG A 577ILE A 556PHE A 619 | None | 1.10A | 2qb4A-3b2rA:undetectable | 2qb4A-3b2rA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bjc | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I) | 4 | ILE A 599ARG A 577ILE A 556PHE A 619 | None | 1.12A | 2qb4A-3bjcA:undetectable | 2qb4A-3bjcA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9b | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 75 (Saccharomycescerevisiae) |
PF00956(NAP) | 4 | ILE A 80PHE A 180ILE A 146PHE A 116 | None | 0.97A | 2qb4A-3c9bA:undetectable | 2qb4A-3c9bA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e1t | HALOGENASE (Chondromycescrocatus) |
PF04820(Trp_halogenase) | 4 | ILE A 210ARG A 206PHE A 92PHE A 312 | None | 0.84A | 2qb4A-3e1tA:0.5 | 2qb4A-3e1tA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e1t | HALOGENASE (Chondromycescrocatus) |
PF04820(Trp_halogenase) | 4 | ILE A 210SER A 212PHE A 92PHE A 94 | None | 1.07A | 2qb4A-3e1tA:0.5 | 2qb4A-3e1tA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdb | PUTATIVEPLP-DEPENDENTBETA-CYSTATHIONASE (Corynebacteriumdiphtheriae) |
PF00155(Aminotran_1_2) | 4 | ILE A 293PHE A 315ILE A 320PHE A 328 | NoneNoneEDO A 388 (-4.7A)None | 1.20A | 2qb4A-3fdbA:undetectable | 2qb4A-3fdbA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gf6 | UNCHARACTERIZEDBACTERIALLIPOPROTEIN (Bacteroidesthetaiotaomicron) |
PF12956(DUF3845) | 4 | ILE A 229SER A 233ARG A 137PHE A 194 | NoneNoneEDO A 2 (-4.1A)None | 1.16A | 2qb4A-3gf6A:undetectable | 2qb4A-3gf6A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3n | KELCH-LIKE PROTEIN11 (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 4 | ARG A 229PHE A 232ILE A 228PHE A 241 | None | 1.04A | 2qb4A-3i3nA:undetectable | 2qb4A-3i3nA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icf | SERINE/THREONINE-PROTEIN PHOSPHATASE T (Saccharomycescerevisiae) |
PF00149(Metallophos)PF08321(PPP5) | 4 | ILE A 430ARG A 420PHE A 421PHE A 373 | None | 0.98A | 2qb4A-3icfA:undetectable | 2qb4A-3icfA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9j | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 1 (Rattusnorvegicus) |
PF00520(Ion_trans) | 4 | ARG A 120PHE A 116ILE A 113PHE A 137 | None | 0.88A | 2qb4A-3j9jA:1.0 | 2qb4A-3j9jA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jv4 | NUCLEAR FACTORNF-KAPPA-B P105SUBUNIT (Mus musculus) |
PF16179(RHD_dimer) | 4 | ILE B 250SER B 340ARG B 281PHE B 311 | None | 1.03A | 2qb4A-3jv4B:undetectable | 2qb4A-3jv4B:11.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kkj | AMINE OXIDASE,FLAVIN-CONTAINING (Pseudomonassyringae groupgenomosp. 3) |
PF01593(Amino_oxidase)PF13450(NAD_binding_8) | 4 | ILE A 12SER A 16PHE A 65PHE A 58 | None | 1.18A | 2qb4A-3kkjA:undetectable | 2qb4A-3kkjA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ksc | LEGA CLASS (Pisum sativum) |
PF00190(Cupin_1) | 4 | ILE A 326ARG A 323ILE A 70PHE A 435 | NoneGOL A 499 (-3.3A)NoneNone | 1.04A | 2qb4A-3kscA:undetectable | 2qb4A-3kscA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lyc | PUTATIVE PECTINASE (Parabacteroidesdistasonis) |
PF10988(DUF2807) | 4 | ILE A 158PHE A 147ILE A 126PHE A 135 | None | 1.02A | 2qb4A-3lycA:undetectable | 2qb4A-3lycA:19.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mpn | TRANSPORTER (Aquifexaeolicus) |
PF00209(SNF) | 6 | ILE A 178SER A 181ARG A 185PHE A 194ILE A 197PHE A 350 | None | 0.14A | 2qb4A-3mpnA:68.1 | 2qb4A-3mpnA:99.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0z | ADENYLATE CYCLASE 2 (Yersinia pestis) |
PF01928(CYTH) | 4 | ILE A 70SER A 68PHE A 35PHE A 5 | 3AT A 181 ( 4.6A)NoneNone3AT A 181 (-3.6A) | 0.92A | 2qb4A-3n0zA:undetectable | 2qb4A-3n0zA:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qg5 | RAD50 (Thermotogamaritima) |
PF13476(AAA_23)PF13558(SbcCD_C) | 4 | ILE A 811PHE A 838ILE A 25PHE A 827 | None | 1.13A | 2qb4A-3qg5A:3.9 | 2qb4A-3qg5A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tlz | MCCF (Escherichiacoli) |
PF02016(Peptidase_S66) | 4 | ILE A 113PHE A 159ILE A 160PHE A 48 | None | 1.06A | 2qb4A-3tlzA:undetectable | 2qb4A-3tlzA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttk | POLYAMINE TRANSPORTPROTEIN (Pseudomonasaeruginosa) |
PF13416(SBP_bac_8) | 4 | ILE A 239ARG A 215PHE A 211ILE A 363 | None | 1.17A | 2qb4A-3ttkA:undetectable | 2qb4A-3ttkA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usz | EXO-1,3/1,4-BETA-GLUCANASE (Pseudoalteromonassp. BB1) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C) | 4 | ILE A 127SER A 580ARG A 133ILE A 138 | None | 1.24A | 2qb4A-3uszA:undetectable | 2qb4A-3uszA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4en8 | HEMAGGLUTININCOMPONENTSHA-22/23/53 (Clostridiumbotulinum) |
PF03505(Clenterotox) | 4 | ILE B 428PHE B 407ILE B 382PHE B 494 | None | 1.25A | 2qb4A-4en8B:undetectable | 2qb4A-4en8B:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0g | SERINE/THREONINE-PROTEIN KINASE ROCO4 (Dictyosteliumdiscoideum) |
PF07714(Pkinase_Tyr) | 4 | ILE A1140ARG A1153PHE A1178ILE A1081 | None | 1.25A | 2qb4A-4f0gA:undetectable | 2qb4A-4f0gA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gtn | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Acinetobactersp. ADP1) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 4 | ILE A 308SER A 306ILE A 316PHE A 111 | None | 1.13A | 2qb4A-4gtnA:undetectable | 2qb4A-4gtnA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hiz | ENDOSIALIDASE (Enterobacteriaphage phi92) |
PF12217(End_beta_propel)PF12218(End_N_terminal)PF12219(End_tail_spike) | 4 | ILE A 425SER A 367PHE A 474ILE A 483 | None | 1.11A | 2qb4A-4hizA:undetectable | 2qb4A-4hizA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i0w | PROTEASE CSPB (Clostridiumperfringens) |
PF00082(Peptidase_S8) | 4 | ILE B 190SER B 480ILE B 129PHE B 124 | None | 1.19A | 2qb4A-4i0wB:undetectable | 2qb4A-4i0wB:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i0w | PROTEASE CSPB (Clostridiumperfringens) |
PF00082(Peptidase_S8) | 4 | ILE B 190SER B 480ILE B 210PHE B 124 | None | 1.23A | 2qb4A-4i0wB:undetectable | 2qb4A-4i0wB:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kjr | CATION EXCHANGERYFKE (Bacillussubtilis) |
PF01699(Na_Ca_ex) | 4 | ILE A 87SER A 91ILE A 74PHE A 78 | None | 1.19A | 2qb4A-4kjrA:2.9 | 2qb4A-4kjrA:24.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s2m | BETA-LACTAMASE (Enterobactercloacae) |
PF00905(Transpeptidase) | 4 | ILE A 130PHE A 156ILE A 162PHE A 72 | None | 1.15A | 2qb4A-4s2mA:undetectable | 2qb4A-4s2mA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ttw | CENTRIOLE PROTEIN (Chlamydomonasreinhardtii) |
PF16531(SAS-6_N) | 4 | ILE A 106ARG A 27PHE A 47PHE A 137 | None | 1.10A | 2qb4A-4ttwA:undetectable | 2qb4A-4ttwA:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9u | KIWELLIN (Actinidiadeliciosa) |
no annotation | 4 | ILE A 162SER A 110ARG A 119ILE A 124 | None | 1.00A | 2qb4A-4x9uA:undetectable | 2qb4A-4x9uA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yv2 | SPERMIDINE SYNTHASE,PUTATIVE (Trypanosomacruzi) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 4 | ILE A 197ARG A 220PHE A 224ILE A 219 | None | 1.00A | 2qb4A-4yv2A:undetectable | 2qb4A-4yv2A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bnz | GLUTAMINE--TRNALIGASE (Pseudomonasaeruginosa) |
PF00749(tRNA-synt_1c)PF03950(tRNA-synt_1c_C) | 4 | SER A 293PHE A 477ILE A 495PHE A 491 | None | 1.01A | 2qb4A-5bnzA:undetectable | 2qb4A-5bnzA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cb2 | PROTEIN SEY1 (Candidaalbicans) |
PF05879(RHD3) | 4 | ILE A 60SER A 62PHE A 145ILE A 32 | None | 1.02A | 2qb4A-5cb2A:2.0 | 2qb4A-5cb2A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e0e | CYTOCHROME P450FAMILY 2 SUBFAMILY B (Neotoma lepida) |
PF00067(p450) | 4 | SER A 160PHE A 157ILE A 453PHE A 171 | None | 1.13A | 2qb4A-5e0eA:undetectable | 2qb4A-5e0eA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyb | DNA-BINDING PROTEINREB1 (Schizosaccharomycespombe) |
PF00249(Myb_DNA-binding) | 4 | ILE A 249PHE A 283ILE A 280PHE A 267 | None | 1.17A | 2qb4A-5eybA:undetectable | 2qb4A-5eybA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fuu | HIV-1 ENVELOPEGLYCOPROTEIN GP160 (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 4 | ILE A 423SER A 195ARG A 192PHE A 176 | None | 0.96A | 2qb4A-5fuuA:undetectable | 2qb4A-5fuuA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hj5 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Vibrio cholerae) |
PF01182(Glucosamine_iso) | 4 | ILE A 20PHE A 63ILE A 99PHE A 93 | None | 1.17A | 2qb4A-5hj5A:undetectable | 2qb4A-5hj5A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8g | ANTIFREEZE PROTEIN (Marinomonasprimoryensis) |
no annotation | 4 | ILE A 364ARG A 368PHE A 367PHE A 326 | None | 0.86A | 2qb4A-5k8gA:undetectable | 2qb4A-5k8gA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kni | TANKYRASE-1 (Homo sapiens) |
PF07647(SAM_2) | 4 | ILE A1068ARG A1044PHE A1047ILE A1031 | None | 1.07A | 2qb4A-5kniA:undetectable | 2qb4A-5kniA:8.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lmg | DNA TOPOISOMERASE2-ASSOCIATED PROTEINPAT1 (Saccharomycescerevisiae) |
PF09770(PAT1) | 4 | ILE A 565SER A 568PHE A 587ILE A 533 | None | 1.13A | 2qb4A-5lmgA:undetectable | 2qb4A-5lmgA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mp0 | M7GPPPN-MRNAHYDROLASE (Homo sapiens) |
PF00293(NUDIX) | 4 | ILE D 176ARG D 233ILE D 232PHE D 126 | None | 1.07A | 2qb4A-5mp0D:undetectable | 2qb4A-5mp0D:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ufl | PROTEIN CIP2A (Homo sapiens) |
no annotation | 4 | ILE A 393PHE A 370ILE A 369PHE A 385 | None | 0.93A | 2qb4A-5uflA:3.1 | 2qb4A-5uflA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uqz | GLUCAN-BINDINGPROTEIN C, GBPC (Streptococcusmutans) |
no annotation | 4 | ILE A 277PHE A 326ILE A 272PHE A 189 | None | 1.17A | 2qb4A-5uqzA:undetectable | 2qb4A-5uqzA:10.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8f | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 3ORIGIN RECOGNITIONCOMPLEX SUBUNIT 5 (Saccharomycescerevisiae) |
PF13401(AAA_22)PF14630(ORC5_C)no annotation | 4 | SER C 254ARG C 257PHE E 256ILE E 255 | NoneNoneAGS E2001 (-4.8A)None | 1.22A | 2qb4A-5v8fC:undetectable | 2qb4A-5v8fC:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlj | NUCLEAR DISTRIBUTIONPROTEIN PAC1 (Saccharomycescerevisiae) |
PF00400(WD40) | 4 | ILE B 340SER B 302ILE B 387PHE B 407 | None | 0.91A | 2qb4A-5vljB:undetectable | 2qb4A-5vljB:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7z | DNA POLYMERASE IIISUBUNIT BETA (Rickettsiaconorii) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | ARG A 176PHE A 372ILE A 362PHE A 364 | None | 1.01A | 2qb4A-5w7zA:undetectable | 2qb4A-5w7zA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wc8 | SIAD (Mannheimiahaemolytica) |
no annotation | 4 | ILE M 369PHE M 376ILE M 379PHE M 361 | None | 1.10A | 2qb4A-5wc8M:undetectable | 2qb4A-5wc8M:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x3t | RIBONUCLEASE VAPC26 (Mycobacteriumtuberculosis) |
PF01850(PIN) | 4 | ILE B 84ARG B 106ILE B 2PHE B 120 | None | 1.07A | 2qb4A-5x3tB:undetectable | 2qb4A-5x3tB:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmc | E3 UBIQUITIN-PROTEINLIGASE ITCHY (Mus musculus) |
PF00397(WW)PF00632(HECT) | 4 | ILE A 602ARG A 627PHE A 624ILE A 628 | None | 1.10A | 2qb4A-5xmcA:undetectable | 2qb4A-5xmcA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xop | CALCIUM-BINDINGPROTEIN 1 (EHCBP1),PUTATIVE (Entamoebahistolytica) |
no annotation | 4 | ILE A 41SER A 44PHE A 61ILE A 65 | None | 0.85A | 2qb4A-5xopA:undetectable | 2qb4A-5xopA:9.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y30 | LEUCINE-RICHGLIOMA-INACTIVATEDPROTEIN 1 (Homo sapiens) |
no annotation | 4 | ILE A 61PHE A 98ILE A 122PHE A 111 | None | 0.97A | 2qb4A-5y30A:undetectable | 2qb4A-5y30A:9.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y31 | LEUCINE-RICHGLIOMA-INACTIVATEDPROTEIN 1 (Homo sapiens) |
no annotation | 4 | ILE B 61PHE B 98ILE B 122PHE B 111 | None | 0.95A | 2qb4A-5y31B:undetectable | 2qb4A-5y31B:9.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ay4 | CYP51, STEROL14ALPHA-DEMETHYLASE (Naegleriafowleri) |
no annotation | 4 | ILE A 381PHE A 83ILE A 61PHE A 53 | None | 1.00A | 2qb4A-6ay4A:undetectable | 2qb4A-6ay4A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | PROTEIN CFT1 (Saccharomycescerevisiae) |
no annotation | 4 | ILE A 709SER A 662PHE A 734PHE A 744 | None | 1.11A | 2qb4A-6eojA:undetectable | 2qb4A-6eojA:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f42 | DNA-DIRECTED RNAPOLYMERASE IIISUBUNIT RPC2 (Saccharomycescerevisiae) |
no annotation | 4 | ILE B 613ARG B 580ARG B 579PHE B 637 | None | 1.12A | 2qb4A-6f42B:undetectable | 2qb4A-6f42B:9.63 |