SIMILAR PATTERNS OF AMINO ACIDS FOR 2QB4_A_DSMA802

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3q PROTEIN (NUCLEAR
FACTOR KAPPA-B P52)

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 ILE A 230
SER A 318
ARG A 261
PHE A 289
 None
 0.82A 2qb4A-1a3qA:
2.0		 2qb4A-1a3qA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 ILE A 578
ARG A 602
PHE A 581
PHE A 506
 None
 1.10A 2qb4A-1bf5A:
0.0		 2qb4A-1bf5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Escherichia
coli) 		PF01182
(Glucosamine_iso) 		4 ILE A  20
PHE A  63
ILE A  99
PHE A  93
 None
 1.09A 2qb4A-1fs5A:
0.0		 2qb4A-1fs5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htw HI0065

(Haemophilus
influenzae) 		PF02367
(TsaE) 		4 ILE A 140
PHE A 156
ILE A 152
PHE A  21
 None
 1.22A 2qb4A-1htwA:
undetectable		 2qb4A-1htwA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j26 IMMATURE COLON
CARCINOMA TRANSCRIPT
1

(Mus musculus) 		PF00472
(RF-1) 		4 ILE A  17
SER A  14
ILE A  64
PHE A  48
 None
 0.88A 2qb4A-1j26A:
undetectable		 2qb4A-1j26A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ILE A 291
ARG A 296
ILE A 309
PHE A 201
 None
 1.12A 2qb4A-1j3uA:
0.8		 2qb4A-1j3uA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jb7 TELOMERE-BINDING
PROTEIN BETA SUBUNIT

(Sterkiella nova) 		PF07404
(TEBP_beta) 		4 ILE B  90
PHE B  63
ILE B  80
PHE B  50
 None
 1.08A 2qb4A-1jb7B:
undetectable		 2qb4A-1jb7B:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE

(Homo sapiens) 		PF01182
(Glucosamine_iso) 		4 ILE A  20
PHE A  63
ILE A  99
PHE A  93
 None
 1.06A 2qb4A-1ne7A:
0.0		 2qb4A-1ne7A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 ILE A 359
PHE A 340
ILE A 175
PHE A 406
 None
 1.13A 2qb4A-1o5tA:
0.0		 2qb4A-1o5tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		4 ILE B 152
SER B 110
PHE B 107
ILE B 105
 None
 1.21A 2qb4A-1ox4B:
0.0		 2qb4A-1ox4B:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyz HYPOTHETICAL PROTEIN
YIBA

(Escherichia
coli) 		PF13646
(HEAT_2) 		4 ILE A 214
ARG A 194
PHE A 197
ILE A 193
 None
 0.75A 2qb4A-1oyzA:
0.0		 2qb4A-1oyzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		4 ILE A  30
ARG A  44
PHE A  45
PHE A 239
 None
 0.99A 2qb4A-1pegA:
undetectable		 2qb4A-1pegA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		4 ILE X  83
PHE X 206
ILE X 197
PHE X  90
 None
 1.24A 2qb4A-1pp1X:
0.0		 2qb4A-1pp1X:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 ILE A 359
PHE A 340
ILE A 175
PHE A 406
 None
None
TYM  A 501 ( 4.5A)
None
 1.02A 2qb4A-1r6uA:
undetectable		 2qb4A-1r6uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT

(Homo sapiens) 		PF08785
(Ku_PK_bind) 		4 ILE A  81
ARG A  96
PHE A  97
ILE A 128
 None
 1.03A 2qb4A-1rw2A:
undetectable		 2qb4A-1rw2A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 ILE P 253
SER P 343
ARG P 284
PHE P 314
 None
 0.93A 2qb4A-1svcP:
undetectable		 2qb4A-1svcP:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v33 DNA PRIMASE SMALL
SUBUNIT

(Pyrococcus
horikoshii) 		PF01896
(DNA_primase_S) 		4 SER A 271
ARG A 216
ILE A 124
PHE A 279
 None
 1.25A 2qb4A-1v33A:
undetectable		 2qb4A-1v33A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcz RNASE NGR3

(Nicotiana
glutinosa) 		PF00445
(Ribonuclease_T2) 		4 ILE A 147
ARG A 116
PHE A  36
PHE A 201
 None
 1.15A 2qb4A-1vczA:
undetectable		 2qb4A-1vczA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpm ACYL-COA HYDROLASE

(Bacillus
halodurans) 		PF03061
(4HBT) 		4 ILE A  38
ARG A  16
ILE A  29
PHE A  64
 None
 1.04A 2qb4A-1vpmA:
undetectable		 2qb4A-1vpmA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w33 BBCRASP-1

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		4 ILE A 163
SER A 167
ILE A 139
PHE A 104
 None
 1.11A 2qb4A-1w33A:
undetectable		 2qb4A-1w33A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wko TERMINAL FLOWER 1
PROTEIN

(Arabidopsis
thaliana) 		PF01161
(PBP) 		4 ARG A 143
PHE A 146
ILE A 140
PHE A 151
 None
 1.15A 2qb4A-1wkoA:
undetectable		 2qb4A-1wkoA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzx COG3291: FOG: PKD
REPEAT

(Ruminiclostridium
thermocellum) 		no annotation 4 ILE A 123
PHE A 172
ILE A 175
PHE A 160
 None
 1.06A 2qb4A-1wzxA:
undetectable		 2qb4A-1wzxA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		4 ARG A2220
PHE A2375
ILE A2404
PHE A2371
 None
 1.16A 2qb4A-1xktA:
undetectable		 2qb4A-1xktA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT

(Pyrococcus
abyssi) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		4 ILE A 251
ARG A 201
ILE A 243
PHE A 182
 None
 1.00A 2qb4A-1yz6A:
undetectable		 2qb4A-1yz6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvt BETA-1,4-MANNANASE

(Cellulomonas
fimi) 		PF02156
(Glyco_hydro_26) 		4 ILE A 168
SER A 158
PHE A  94
ILE A  74
 None
 0.81A 2qb4A-2bvtA:
undetectable		 2qb4A-2bvtA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db1 HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN F

(Mus musculus) 		PF00076
(RRM_1) 		4 ILE A  46
SER A  54
ARG A  81
ILE A  83
 None
 1.22A 2qb4A-2db1A:
undetectable		 2qb4A-2db1A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		4 ILE A  88
SER A 104
PHE A  33
ILE A  66
 None
 1.04A 2qb4A-2f91A:
undetectable		 2qb4A-2f91A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fji EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		PF06046
(Sec6) 		4 ILE 1 546
SER 1 549
PHE 1 652
ILE 1 601
 None
 1.11A 2qb4A-2fji1:
undetectable		 2qb4A-2fji1:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		4 ARG A1890
ARG A1893
PHE A1894
PHE A1805
 None
 1.14A 2qb4A-2fr1A:
undetectable		 2qb4A-2fr1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		4 ILE A1887
ARG A1890
ARG A1893
PHE A1894
 None
 1.07A 2qb4A-2fr1A:
undetectable		 2qb4A-2fr1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2q GLUTAREDOXIN-2

(Vaccinia virus) 		PF05768
(DUF836) 		4 ILE A  88
SER A  91
PHE A  94
ILE A  15
 None
 1.11A 2qb4A-2g2qA:
undetectable		 2qb4A-2g2qA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		4 ILE D 205
SER D 254
PHE D 213
ILE D 111
 None
 1.10A 2qb4A-2gafD:
undetectable		 2qb4A-2gafD:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7n PANTOTHENATE KINASE
1

(Homo sapiens) 		PF03630
(Fumble) 		4 ILE A 243
PHE A 312
ILE A 310
PHE A 320
 None
 1.06A 2qb4A-2i7nA:
undetectable		 2qb4A-2i7nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 4 ILE A 100
PHE A 165
ILE A 204
PHE A 183
 None
 1.15A 2qb4A-2invA:
undetectable		 2qb4A-2invA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kr5 AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF00550
(PP-binding) 		4 ILE A  26
ARG A  53
ILE A  50
PHE A  37
 None
 1.16A 2qb4A-2kr5A:
undetectable		 2qb4A-2kr5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE A  79
SER A 105
PHE A 327
ILE A 326
 None
 1.01A 2qb4A-2og2A:
undetectable		 2qb4A-2og2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 ILE A 247
PHE A 338
ILE A 259
PHE A 317
 None
 1.24A 2qb4A-2v26A:
1.4		 2qb4A-2v26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 SER A 150
ARG A 667
PHE A 665
ILE A 488
 None
 1.04A 2qb4A-2v26A:
1.4		 2qb4A-2v26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5e GDNF FAMILY RECEPTOR
ALPHA-1

(Rattus
norvegicus) 		PF02351
(GDNF) 		4 ILE A 293
ARG A 225
PHE A 213
ILE A 342
 None
 1.22A 2qb4A-2v5eA:
undetectable		 2qb4A-2v5eA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7y CHAPERONE PROTEIN
DNAK

(Geobacillus
kaustophilus) 		PF00012
(HSP70) 		4 ILE A 370
ARG A 425
PHE A 426
ILE A 468
 None
 0.95A 2qb4A-2v7yA:
undetectable		 2qb4A-2v7yA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp0 HOBA

(Helicobacter
pylori) 		PF12163
(HobA) 		4 ILE A  65
PHE A 166
ILE A  37
PHE A 134
 None
 1.20A 2qb4A-2wp0A:
undetectable		 2qb4A-2wp0A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 SER B  40
PHE B 112
ILE B 114
PHE B  53
 None
 1.14A 2qb4A-2x25B:
undetectable		 2qb4A-2x25B:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Candida
albicans) 		PF01704
(UDPGP) 		4 ILE A   9
SER A  12
PHE A  22
PHE A  36
 None
 1.16A 2qb4A-2yqhA:
undetectable		 2qb4A-2yqhA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzj GLUCURONAN LYASE A

(Trichoderma
reesei) 		PF14099
(Polysacc_lyase) 		4 ILE A 114
ARG A  75
PHE A  74
PHE A 172
 None
CIT  A 240 (-2.8A)
None
None
 0.90A 2qb4A-2zzjA:
undetectable		 2qb4A-2zzjA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agb RED CHLOROPHYLL
CATABOLITE
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF06405
(RCC_reductase) 		4 ILE A 135
SER A 137
ILE A 312
PHE A 296
 None
 1.15A 2qb4A-3agbA:
undetectable		 2qb4A-3agbA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 599
ARG A 577
ILE A 556
PHE A 619
 None
 1.10A 2qb4A-3b2rA:
undetectable		 2qb4A-3b2rA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ILE A 599
ARG A 577
ILE A 556
PHE A 619
 None
 1.12A 2qb4A-3bjcA:
undetectable		 2qb4A-3bjcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
PHE A 180
ILE A 146
PHE A 116
 None
 0.97A 2qb4A-3c9bA:
undetectable		 2qb4A-3c9bA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		4 ILE A 210
ARG A 206
PHE A  92
PHE A 312
 None
 0.84A 2qb4A-3e1tA:
0.5		 2qb4A-3e1tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		4 ILE A 210
SER A 212
PHE A  92
PHE A  94
 None
 1.07A 2qb4A-3e1tA:
0.5		 2qb4A-3e1tA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		4 ILE A 293
PHE A 315
ILE A 320
PHE A 328
 None
None
EDO  A 388 (-4.7A)
None
 1.20A 2qb4A-3fdbA:
undetectable		 2qb4A-3fdbA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		4 ILE A 229
SER A 233
ARG A 137
PHE A 194
 None
None
EDO  A   2 (-4.1A)
None
 1.16A 2qb4A-3gf6A:
undetectable		 2qb4A-3gf6A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3n KELCH-LIKE PROTEIN
11

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		4 ARG A 229
PHE A 232
ILE A 228
PHE A 241
 None
 1.04A 2qb4A-3i3nA:
undetectable		 2qb4A-3i3nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icf SERINE/THREONINE-PRO
TEIN PHOSPHATASE T

(Saccharomyces
cerevisiae) 		PF00149
(Metallophos)
PF08321
(PPP5) 		4 ILE A 430
ARG A 420
PHE A 421
PHE A 373
 None
 0.98A 2qb4A-3icfA:
undetectable		 2qb4A-3icfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9j TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus) 		PF00520
(Ion_trans) 		4 ARG A 120
PHE A 116
ILE A 113
PHE A 137
 None
 0.88A 2qb4A-3j9jA:
1.0		 2qb4A-3j9jA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv4 NUCLEAR FACTOR
NF-KAPPA-B P105
SUBUNIT

(Mus musculus) 		PF16179
(RHD_dimer) 		4 ILE B 250
SER B 340
ARG B 281
PHE B 311
 None
 1.03A 2qb4A-3jv4B:
undetectable		 2qb4A-3jv4B:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		4 ILE A  12
SER A  16
PHE A  65
PHE A  58
 None
 1.18A 2qb4A-3kkjA:
undetectable		 2qb4A-3kkjA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksc LEGA CLASS

(Pisum sativum) 		PF00190
(Cupin_1) 		4 ILE A 326
ARG A 323
ILE A  70
PHE A 435
 None
GOL  A 499 (-3.3A)
None
None
 1.04A 2qb4A-3kscA:
undetectable		 2qb4A-3kscA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyc PUTATIVE PECTINASE

(Parabacteroides
distasonis) 		PF10988
(DUF2807) 		4 ILE A 158
PHE A 147
ILE A 126
PHE A 135
 None
 1.02A 2qb4A-3lycA:
undetectable		 2qb4A-3lycA:
19.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		6 ILE A 178
SER A 181
ARG A 185
PHE A 194
ILE A 197
PHE A 350
 None
 0.14A 2qb4A-3mpnA:
68.1		 2qb4A-3mpnA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0z ADENYLATE CYCLASE 2

(Yersinia pestis) 		PF01928
(CYTH) 		4 ILE A  70
SER A  68
PHE A  35
PHE A   5
 3AT  A 181 ( 4.6A)
None
None
3AT  A 181 (-3.6A)
 0.92A 2qb4A-3n0zA:
undetectable		 2qb4A-3n0zA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qg5 RAD50

(Thermotoga
maritima) 		PF13476
(AAA_23)
PF13558
(SbcCD_C) 		4 ILE A 811
PHE A 838
ILE A  25
PHE A 827
 None
 1.13A 2qb4A-3qg5A:
3.9		 2qb4A-3qg5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli) 		PF02016
(Peptidase_S66) 		4 ILE A 113
PHE A 159
ILE A 160
PHE A  48
 None
 1.06A 2qb4A-3tlzA:
undetectable		 2qb4A-3tlzA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttk POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		4 ILE A 239
ARG A 215
PHE A 211
ILE A 363
 None
 1.17A 2qb4A-3ttkA:
undetectable		 2qb4A-3ttkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ILE A 127
SER A 580
ARG A 133
ILE A 138
 None
 1.24A 2qb4A-3uszA:
undetectable		 2qb4A-3uszA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		4 ILE B 428
PHE B 407
ILE B 382
PHE B 494
 None
 1.25A 2qb4A-4en8B:
undetectable		 2qb4A-4en8B:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		4 ILE A1140
ARG A1153
PHE A1178
ILE A1081
 None
 1.25A 2qb4A-4f0gA:
undetectable		 2qb4A-4f0gA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ILE A 308
SER A 306
ILE A 316
PHE A 111
 None
 1.13A 2qb4A-4gtnA:
undetectable		 2qb4A-4gtnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hiz ENDOSIALIDASE

(Enterobacteria
phage phi92) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		4 ILE A 425
SER A 367
PHE A 474
ILE A 483
 None
 1.11A 2qb4A-4hizA:
undetectable		 2qb4A-4hizA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 ILE B 190
SER B 480
ILE B 129
PHE B 124
 None
 1.19A 2qb4A-4i0wB:
undetectable		 2qb4A-4i0wB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		4 ILE B 190
SER B 480
ILE B 210
PHE B 124
 None
 1.23A 2qb4A-4i0wB:
undetectable		 2qb4A-4i0wB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjr CATION EXCHANGER
YFKE

(Bacillus
subtilis) 		PF01699
(Na_Ca_ex) 		4 ILE A  87
SER A  91
ILE A  74
PHE A  78
 None
 1.19A 2qb4A-4kjrA:
2.9		 2qb4A-4kjrA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2m BETA-LACTAMASE

(Enterobacter
cloacae) 		PF00905
(Transpeptidase) 		4 ILE A 130
PHE A 156
ILE A 162
PHE A  72
 None
 1.15A 2qb4A-4s2mA:
undetectable		 2qb4A-4s2mA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ttw CENTRIOLE PROTEIN

(Chlamydomonas
reinhardtii) 		PF16531
(SAS-6_N) 		4 ILE A 106
ARG A  27
PHE A  47
PHE A 137
 None
 1.10A 2qb4A-4ttwA:
undetectable		 2qb4A-4ttwA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9u KIWELLIN

(Actinidia
deliciosa) 		no annotation 4 ILE A 162
SER A 110
ARG A 119
ILE A 124
 None
 1.00A 2qb4A-4x9uA:
undetectable		 2qb4A-4x9uA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 ILE A 197
ARG A 220
PHE A 224
ILE A 219
 None
 1.00A 2qb4A-4yv2A:
undetectable		 2qb4A-4yv2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnz GLUTAMINE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 SER A 293
PHE A 477
ILE A 495
PHE A 491
 None
 1.01A 2qb4A-5bnzA:
undetectable		 2qb4A-5bnzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		4 ILE A  60
SER A  62
PHE A 145
ILE A  32
 None
 1.02A 2qb4A-5cb2A:
2.0		 2qb4A-5cb2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		4 SER A 160
PHE A 157
ILE A 453
PHE A 171
 None
 1.13A 2qb4A-5e0eA:
undetectable		 2qb4A-5e0eA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyb DNA-BINDING PROTEIN
REB1

(Schizosaccharomyces
pombe) 		PF00249
(Myb_DNA-binding) 		4 ILE A 249
PHE A 283
ILE A 280
PHE A 267
 None
 1.17A 2qb4A-5eybA:
undetectable		 2qb4A-5eybA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuu HIV-1 ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 ILE A 423
SER A 195
ARG A 192
PHE A 176
 None
 0.96A 2qb4A-5fuuA:
undetectable		 2qb4A-5fuuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		4 ILE A  20
PHE A  63
ILE A  99
PHE A  93
 None
 1.17A 2qb4A-5hj5A:
undetectable		 2qb4A-5hj5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 ILE A 364
ARG A 368
PHE A 367
PHE A 326
 None
 0.86A 2qb4A-5k8gA:
undetectable		 2qb4A-5k8gA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kni TANKYRASE-1

(Homo sapiens) 		PF07647
(SAM_2) 		4 ILE A1068
ARG A1044
PHE A1047
ILE A1031
 None
 1.07A 2qb4A-5kniA:
undetectable		 2qb4A-5kniA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 ILE A 565
SER A 568
PHE A 587
ILE A 533
 None
 1.13A 2qb4A-5lmgA:
undetectable		 2qb4A-5lmgA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp0 M7GPPPN-MRNA
HYDROLASE

(Homo sapiens) 		PF00293
(NUDIX) 		4 ILE D 176
ARG D 233
ILE D 232
PHE D 126
 None
 1.07A 2qb4A-5mp0D:
undetectable		 2qb4A-5mp0D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufl PROTEIN CIP2A

(Homo sapiens) 		no annotation 4 ILE A 393
PHE A 370
ILE A 369
PHE A 385
 None
 0.93A 2qb4A-5uflA:
3.1		 2qb4A-5uflA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqz GLUCAN-BINDING
PROTEIN C, GBPC

(Streptococcus
mutans) 		no annotation 4 ILE A 277
PHE A 326
ILE A 272
PHE A 189
 None
 1.17A 2qb4A-5uqzA:
undetectable		 2qb4A-5uqzA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF13401
(AAA_22)
PF14630
(ORC5_C)
no annotation 		4 SER C 254
ARG C 257
PHE E 256
ILE E 255
 None
None
AGS  E2001 (-4.8A)
None
 1.22A 2qb4A-5v8fC:
undetectable		 2qb4A-5v8fC:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE B 340
SER B 302
ILE B 387
PHE B 407
 None
 0.91A 2qb4A-5vljB:
undetectable		 2qb4A-5vljB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7z DNA POLYMERASE III
SUBUNIT BETA

(Rickettsia
conorii) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 ARG A 176
PHE A 372
ILE A 362
PHE A 364
 None
 1.01A 2qb4A-5w7zA:
undetectable		 2qb4A-5w7zA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 4 ILE M 369
PHE M 376
ILE M 379
PHE M 361
 None
 1.10A 2qb4A-5wc8M:
undetectable		 2qb4A-5wc8M:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3t RIBONUCLEASE VAPC26

(Mycobacterium
tuberculosis) 		PF01850
(PIN) 		4 ILE B  84
ARG B 106
ILE B   2
PHE B 120
 None
 1.07A 2qb4A-5x3tB:
undetectable		 2qb4A-5x3tB:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		4 ILE A 602
ARG A 627
PHE A 624
ILE A 628
 None
 1.10A 2qb4A-5xmcA:
undetectable		 2qb4A-5xmcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xop CALCIUM-BINDING
PROTEIN 1 (EHCBP1),
PUTATIVE

(Entamoeba
histolytica) 		no annotation 4 ILE A  41
SER A  44
PHE A  61
ILE A  65
 None
 0.85A 2qb4A-5xopA:
undetectable		 2qb4A-5xopA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 ILE A  61
PHE A  98
ILE A 122
PHE A 111
 None
 0.97A 2qb4A-5y30A:
undetectable		 2qb4A-5y30A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 ILE B  61
PHE B  98
ILE B 122
PHE B 111
 None
 0.95A 2qb4A-5y31B:
undetectable		 2qb4A-5y31B:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 4 ILE A 381
PHE A  83
ILE A  61
PHE A  53
 None
 1.00A 2qb4A-6ay4A:
undetectable		 2qb4A-6ay4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A 709
SER A 662
PHE A 734
PHE A 744
 None
 1.11A 2qb4A-6eojA:
undetectable		 2qb4A-6eojA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 ILE B 613
ARG B 580
ARG B 579
PHE B 637
 None
 1.12A 2qb4A-6f42B:
undetectable		 2qb4A-6f42B:
9.63