SIMILAR PATTERNS OF AMINO ACIDS FOR 2QB4_A_DSMA801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		5 ARG A 155
ILE A 167
PHE A 159
PHE A 130
LEU A 100
 None
 1.14A 2qb4A-1bs9A:
undetectable		 2qb4A-1bs9A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1del DEOXYNUCLEOSIDE
MONOPHOSPHATE KINASE

(Escherichia
virus T4) 		no annotation 5 ILE A  82
PHE A  61
ALA A  48
PHE A  47
LEU A  74
 None
 1.14A 2qb4A-1delA:
undetectable		 2qb4A-1delA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 GLN C 172
ILE C 136
ALA C 142
PHE C 141
LEU C 181
 None
 1.05A 2qb4A-1ea9C:
undetectable		 2qb4A-1ea9C:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens) 		PF09128
(RGS-like) 		5 LEU F 324
LEU F 317
ARG F 320
PHE F 311
LEU F 436
 None
 1.00A 2qb4A-1htjF:
0.0		 2qb4A-1htjF:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae) 		PF13649
(Methyltransf_25) 		5 LEU A 130
LEU A 161
ILE A 149
ALA A 239
LEU A 153
 None
 1.16A 2qb4A-1im8A:
0.0		 2qb4A-1im8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 LEU A 663
ILE A  25
ALA A 668
PHE A  29
LEU A 737
 None
 1.11A 2qb4A-1j1wA:
0.0		 2qb4A-1j1wA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 LEU A 225
LEU A 228
ARG A 226
ILE A 203
ASP A 262
 None
 0.98A 2qb4A-1szsA:
0.0		 2qb4A-1szsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A  51
ILE A 136
ALA A 104
PHE A 120
LEU A  35
 None
 1.12A 2qb4A-1tuoA:
0.0		 2qb4A-1tuoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 104
VAL A 261
ILE A 200
ALA A 110
LEU A 166
 None
 1.09A 2qb4A-1u08A:
0.0		 2qb4A-1u08A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukv GTP-BINDING PROTEIN
YPT1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 GLN Y 168
ILE Y  61
ALA Y 161
PHE Y 162
LEU Y  13
 None
 1.00A 2qb4A-1ukvY:
undetectable		 2qb4A-1ukvY:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU A  54
ILE A  51
PHE A  79
PHE A 150
LEU A  75
 None
 1.14A 2qb4A-1v0bA:
0.0		 2qb4A-1v0bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		6 LEU A  21
LEU A  15
ILE A 155
PHE A 159
LEU A 119
ASP A 123
 None
 1.40A 2qb4A-1yd9A:
undetectable		 2qb4A-1yd9A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzn GTP-BINDING PROTEIN
YPT1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		5 GLN A 168
ILE A  61
ALA A 161
PHE A 162
LEU A  13
 None
 1.04A 2qb4A-1yznA:
undetectable		 2qb4A-1yznA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae6 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		5 LEU A   9
ARG A   8
ALA A  55
LEU A  18
ASP A  14
 None
 1.09A 2qb4A-2ae6A:
undetectable		 2qb4A-2ae6A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 LEU A 147
ARG A 148
ILE A 185
LEU A 189
ASP A 201
 None
 1.11A 2qb4A-2f31A:
undetectable		 2qb4A-2f31A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF08442
(ATP-grasp_2) 		5 GLN A 110
ILE B 236
ALA B 200
PHE B 225
LEU B  11
 None
 1.14A 2qb4A-2fpgA:
undetectable		 2qb4A-2fpgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 177
LEU A 191
ILE A 179
PHE A 143
LEU A 159
 None
 1.17A 2qb4A-2ft3A:
undetectable		 2qb4A-2ft3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ARG A 325
ILE A  92
PHE A 124
LEU A 272
ASP A 276
 BME  A1592 ( 4.0A)
None
None
None
None
 0.85A 2qb4A-2j5cA:
undetectable		 2qb4A-2j5cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j85 STIV B116

(Sulfolobus
turreted
icosahedral
virus 1) 		PF08960
(DUF1874) 		5 LEU A  57
LEU A  61
ILE A  84
PHE A  32
LEU A   6
 None
 1.07A 2qb4A-2j85A:
undetectable		 2qb4A-2j85A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 LEU A 498
VAL A 512
ILE A 413
ALA A 502
PHE A 501
 None
 1.13A 2qb4A-2jirA:
undetectable		 2qb4A-2jirA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvq GLUTATHIONE
S-TRANSFERASE

(Ochrobactrum
anthropi) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A  70
ILE A  17
ALA A  81
PHE A  82
ASP A 155
 None
 1.07A 2qb4A-2pvqA:
undetectable		 2qb4A-2pvqA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyz UNCHARACTERIZED
PROTEIN

(Clostridium
tetani) 		PF09643
(YopX) 		5 VAL A  20
GLN A  25
ILE A  42
ALA A  11
PHE A  52
 None
 1.11A 2qb4A-2qyzA:
undetectable		 2qb4A-2qyzA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 LEU A 742
LEU A 744
ILE A 769
PHE A 758
LEU A 714
 None
 1.01A 2qb4A-2v26A:
1.4		 2qb4A-2v26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3z PUTATIVE DEACETYLASE

(Streptococcus
mutans) 		PF01522
(Polysacc_deac_1) 		5 LEU A 290
VAL A 243
ILE A 125
PHE A 113
LEU A 129
 None
 1.09A 2qb4A-2w3zA:
undetectable		 2qb4A-2w3zA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		5 LEU A 190
PHE A 280
ALA A 197
ASP A 291
ASP A 288
 None
 1.15A 2qb4A-2zq5A:
0.9		 2qb4A-2zq5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 LEU A 202
LEU A 200
ILE A 172
ALA A 195
PHE A 229
 CRO  A 224 ( 4.7A)
None
None
None
None
 1.16A 2qb4A-3evrA:
undetectable		 2qb4A-3evrA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2e SIRV COAT PROTEIN

(Rudivirus) 		PF12193
(Sulf_coat_C) 		5 VAL A  55
GLN A  58
ILE A 100
ALA A  84
LEU A  96
 None
 1.15A 2qb4A-3f2eA:
2.1		 2qb4A-3f2eA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Lactobacillus
delbrueckii) 		PF06325
(PrmA) 		5 LEU A 255
ILE A 258
ALA A 247
PHE A 273
LEU A 261
 None
 1.04A 2qb4A-3grzA:
undetectable		 2qb4A-3grzA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 186
GLN A 174
ILE A 272
PHE A 299
LEU A 261
 None
 0.82A 2qb4A-3h3jA:
undetectable		 2qb4A-3h3jA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 LEU A 383
ARG A 407
ILE A  55
PHE A  39
ASP A 311
 None
 1.02A 2qb4A-3ialA:
undetectable		 2qb4A-3ialA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 LEU A 185
LEU A 188
ALA A 247
PHE A 251
LEU A 261
 GOL  A 398 ( 4.6A)
None
None
None
None
 0.99A 2qb4A-3is5A:
undetectable		 2qb4A-3is5A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU A 600
ILE A 613
ALA A 724
PHE A 721
LEU A 668
 None
 1.16A 2qb4A-3lltA:
undetectable		 2qb4A-3lltA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpm PUTATIVE
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF05175
(MTS) 		5 LEU A   8
LEU A   6
ILE A  25
ALA A  93
ASP A  86
 None
 1.02A 2qb4A-3lpmA:
undetectable		 2qb4A-3lpmA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lti DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Escherichia
coli) 		PF04561
(RNA_pol_Rpb2_2) 		5 LEU A 210
ILE A 425
PHE A 385
ALA A 206
LEU A 184
 None
MLY  A 422 ( 4.1A)
None
None
None
 1.09A 2qb4A-3ltiA:
undetectable		 2qb4A-3ltiA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lti DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Escherichia
coli) 		PF04561
(RNA_pol_Rpb2_2) 		5 LEU A 213
LEU A 210
ILE A 425
ALA A 206
LEU A 184
 MLY  A 422 ( 4.1A)
None
MLY  A 422 ( 4.1A)
None
None
 1.06A 2qb4A-3ltiA:
undetectable		 2qb4A-3ltiA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 2

(Mycolicibacterium
smegmatis) 		PF02626
(CT_A_B) 		5 LEU A   8
ALA A  14
PHE A  63
LEU A 151
ASP A 149
 None
 1.16A 2qb4A-3mmlA:
undetectable		 2qb4A-3mmlA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		11 LEU A  25
LEU A  29
VAL A  33
GLN A  34
ILE A 111
PHE A 253
ALA A 319
PHE A 320
LEU A 400
ASP A 401
ASP A 404
 LEU  A 601 (-4.9A)
None
None
None
None
LEU  A 601 (-4.2A)
None
None
None
None
None
 0.47A 2qb4A-3mpnA:
68.1		 2qb4A-3mpnA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		5 LEU A 205
LEU A 208
ARG A 206
ILE A 183
ASP A 242
 None
 1.00A 2qb4A-3nx3A:
undetectable		 2qb4A-3nx3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 LEU A 456
LEU A 454
ILE A 426
ALA A 449
PHE A 483
 C12  A 478 ( 4.6A)
C12  A 478 ( 4.8A)
None
None
None
 1.13A 2qb4A-3osrA:
undetectable		 2qb4A-3osrA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A  30
VAL A  40
ILE A  46
PHE A  57
LEU A  78
 None
 1.05A 2qb4A-3p11A:
undetectable		 2qb4A-3p11A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU B 669
LEU B 673
VAL B 557
ILE B 524
ALA B 554
 None
 1.15A 2qb4A-3pcoB:
undetectable		 2qb4A-3pcoB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		5 LEU A1299
VAL A1306
GLN A1308
ILE A1588
LEU A1151
 None
None
None
None
SAH  A1601 (-3.6A)
 1.12A 2qb4A-3ptaA:
undetectable		 2qb4A-3ptaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pty ARABINOSYLTRANSFERAS
E C

(Mycobacterium
tuberculosis) 		PF14896
(Arabino_trans_C) 		5 LEU A 744
VAL A 736
LEU A1049
ASP A1052
ASP A1051
 None
AFO  A   1 ( 4.9A)
None
None
AFO  A   1 (-4.7A)
 1.15A 2qb4A-3ptyA:
undetectable		 2qb4A-3ptyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q62 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Yersinia pestis) 		PF07977
(FabA) 		6 ARG A   5
VAL A   2
ILE A  40
PHE A  93
LEU A  13
ASP A  12
 None
 1.11A 2qb4A-3q62A:
undetectable		 2qb4A-3q62A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsl PUTATIVE EXPORTED
PROTEIN

(Bordetella
bronchiseptica) 		PF13379
(NMT1_2) 		5 ILE A  37
PHE A 109
ALA A 252
PHE A  59
LEU A  50
 None
 1.17A 2qb4A-3qslA:
undetectable		 2qb4A-3qslA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkd CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		5 ARG A 460
ALA A 507
PHE A 462
LEU A 471
ASP A 469
 None
 0.94A 2qb4A-3rkdA:
undetectable		 2qb4A-3rkdA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF03320
(FBPase_glpX) 		5 LEU A 302
LEU A 318
ILE A 205
ALA A 293
PHE A 292
 None
 0.93A 2qb4A-3rplA:
undetectable		 2qb4A-3rplA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ARG A 370
ILE A 120
PHE A 372
LEU A 549
ASP A 553
 None
 0.71A 2qb4A-3s9vA:
2.0		 2qb4A-3s9vA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip CASPASE

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		5 LEU A 111
GLN A 108
ILE A 114
ALA A 104
LEU A  72
 None
 0.85A 2qb4A-3sipA:
undetectable		 2qb4A-3sipA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 146
ARG A 273
ILE A  91
ASP A 434
ASP A 463
 None
 0.96A 2qb4A-3v9eA:
undetectable		 2qb4A-3v9eA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		5 LEU B  88
LEU B  84
ILE B 137
ALA B  76
LEU B  71
 None
None
None
None
HEM  B 201 (-4.4A)
 1.06A 2qb4A-3wcuB:
undetectable		 2qb4A-3wcuB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae) 		PF00291
(PALP) 		5 LEU A 189
VAL A 235
GLN A 187
ILE A 160
PHE A 172
 None
 1.17A 2qb4A-3x43A:
undetectable		 2qb4A-3x43A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 LEU A1044
LEU A1042
ILE A1014
ALA A1037
PHE A1071
 None
 1.15A 2qb4A-4anjA:
3.2		 2qb4A-4anjA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 LEU A   8
LEU A  86
ARG A 128
VAL A 126
ALA A 123
 None
 1.15A 2qb4A-4e3zA:
undetectable		 2qb4A-4e3zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		5 LEU A 223
LEU A 226
ARG A 224
ILE A 201
ASP A 259
 None
 1.02A 2qb4A-4e77A:
undetectable		 2qb4A-4e77A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 LEU A 146
ILE A  55
ALA A  43
PHE A  44
LEU A 136
 None
 0.97A 2qb4A-4f7zA:
2.1		 2qb4A-4f7zA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 LEU A 131
LEU A 162
ILE A 150
ALA A 240
LEU A 154
 None
 1.07A 2qb4A-4gekA:
undetectable		 2qb4A-4gekA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6n UBIQUITIN
CARBOXYL-HYDROLASE

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		5 LEU A  36
LEU A 218
ILE A 199
ALA A 220
PHE A  49
 None
 0.86A 2qb4A-4i6nA:
undetectable		 2qb4A-4i6nA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 LEU A 131
LEU A 162
ILE A 150
ALA A 240
LEU A 154
 None
 1.09A 2qb4A-4iwnA:
undetectable		 2qb4A-4iwnA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		5 ARG A  65
VAL A  30
ILE A  77
ALA A  73
ASP A  90
 None
 1.14A 2qb4A-4jeuA:
undetectable		 2qb4A-4jeuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqz UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF16253
(DUF4909) 		5 VAL A  72
ILE A 133
PHE A  68
ALA A 140
LEU A  98
 None
PO4  A 201 (-4.0A)
None
None
None
 1.11A 2qb4A-4lqzA:
undetectable		 2qb4A-4lqzA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn7 PUTATIVE
UNCHARACTERIZED
PROTEIN TA0848

(Thermoplasma
acidophilum) 		PF13185
(GAF_2) 		5 LEU A  18
ILE A 108
ALA A 115
PHE A 116
ASP A  26
 None
 1.11A 2qb4A-4mn7A:
undetectable		 2qb4A-4mn7A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		5 LEU A 278
VAL A 280
ILE A  39
PHE A  64
LEU A  27
 None
 1.15A 2qb4A-4ovyA:
undetectable		 2qb4A-4ovyA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfe GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vicugna pacos) 		PF01353
(GFP)
PF07686
(V-set) 		5 LEU A  44
LEU A  42
ILE A  14
ALA A  37
PHE A  71
 None
CRO  A  66 ( 4.8A)
None
None
None
 1.17A 2qb4A-4pfeA:
undetectable		 2qb4A-4pfeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		5 ARG A 460
ALA A 507
PHE A 462
LEU A 471
ASP A 469
 None
 0.99A 2qb4A-4pljA:
undetectable		 2qb4A-4pljA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 LEU A 288
LEU A 284
ILE A 328
ALA A 271
LEU A 305
 None
 1.13A 2qb4A-4q3rA:
undetectable		 2qb4A-4q3rA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		5 LEU A  27
LEU A  30
VAL A  34
GLN A  35
ASP A  69
 None
 1.15A 2qb4A-4qgkA:
undetectable		 2qb4A-4qgkA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Aliivibrio
fischeri) 		PF00092
(VWA) 		5 LEU A  63
LEU A  20
VAL A  22
ILE A  55
ASP A  90
 None
 1.04A 2qb4A-4rckA:
undetectable		 2qb4A-4rckA:
17.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 LEU A  29
ARG A  34
PHE A 230
ASP A 382
ASP A 385
 None
None
TRP  A 601 (-4.4A)
None
None
 0.80A 2qb4A-4us4A:
40.4		 2qb4A-4us4A:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 LEU A  29
ILE A 111
PHE A 230
ASP A 382
ASP A 385
 None
None
TRP  A 601 (-4.4A)
None
None
 0.63A 2qb4A-4us4A:
40.4		 2qb4A-4us4A:
32.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Plasmodium
falciparum) 		PF01353
(GFP)
PF02861
(Clp_N) 		5 LEU A 193
LEU A 191
ILE A 163
ALA A 186
PHE A 220
 CRO  A 215 ( 4.8A)
CRO  A 215 ( 4.9A)
None
None
None
 1.17A 2qb4A-4xbiA:
undetectable		 2qb4A-4xbiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 LEU A 826
LEU A 808
ILE A 786
PHE A 807
LEU A 769
 None
 1.00A 2qb4A-4xmvA:
undetectable		 2qb4A-4xmvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf4 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 LEU A 237
LEU A 235
ILE A 207
ALA A 230
PHE A  21
 4NT  A  15 ( 4.9A)
4NT  A  15 ( 4.8A)
None
None
None
 1.11A 2qb4A-4zf4A:
undetectable		 2qb4A-4zf4A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afe ENDOGLUCANASE CEL5A

([Eubacterium]
cellulosolvens) 		no annotation 5 LEU A 641
ILE A 686
PHE A 628
ALA A 652
LEU A 683
 None
 1.12A 2qb4A-5afeA:
undetectable		 2qb4A-5afeA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP3

(Enterovirus D) 		PF00073
(Rhv) 		5 LEU C  86
VAL C  99
ILE C 167
ALA C 218
ASP C 221
 None
 1.15A 2qb4A-5bnnC:
undetectable		 2qb4A-5bnnC:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvc SERINE RACEMASE

(Zea mays) 		PF00291
(PALP) 		5 LEU A 285
VAL A 289
ILE A  45
ALA A 294
LEU A 301
 None
 0.92A 2qb4A-5cvcA:
undetectable		 2qb4A-5cvcA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 336
ILE A 246
PHE A  24
ALA A 343
LEU A 122
 None
 1.08A 2qb4A-5eytA:
1.2		 2qb4A-5eytA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		5 LEU A 372
LEU A 376
ARG A 373
ILE A 306
ASP A 277
 None
 1.16A 2qb4A-5h5mA:
2.7		 2qb4A-5h5mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl8 TYPE II SECRETION
SYSTEM PROTEIN L

(Klebsiella
pneumoniae) 		PF12693
(GspL_C) 		5 LEU A 390
ILE A 353
ALA A 368
PHE A 364
LEU A 329
 None
 1.13A 2qb4A-5hl8A:
undetectable		 2qb4A-5hl8A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		5 LEU A 297
ARG A 296
ILE A 337
LEU A 287
ASP A 285
 None
None
None
EDO  A 509 (-4.1A)
None
 0.98A 2qb4A-5jijA:
undetectable		 2qb4A-5jijA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 LEU A 232
LEU A 271
ILE A 305
PHE A 262
LEU A 277
 None
 1.14A 2qb4A-5k8rA:
undetectable		 2qb4A-5k8rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms7 LEGIONELLA
PNEUMOPHILA EFFECTOR
PROTEIN RAVZ

(Legionella
pneumophila) 		no annotation 5 LEU A  71
LEU A  74
ILE A 301
ALA A  81
LEU A 293
 None
 0.94A 2qb4A-5ms7A:
2.6		 2qb4A-5ms7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mse GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		no annotation 5 LEU A  44
LEU A  42
ILE A  14
ALA A  37
PHE A  71
 CRO  A  66 ( 4.8A)
None
None
None
None
 1.17A 2qb4A-5mseA:
undetectable		 2qb4A-5mseA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 5 LEU A 109
VAL A 167
GLN A 147
ILE A  88
ALA A 217
 None
 1.10A 2qb4A-5muxA:
undetectable		 2qb4A-5muxA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 LEU A 106
VAL A 108
ILE A 860
ALA A 527
LEU A  55
 None
 1.04A 2qb4A-5nd1A:
0.0		 2qb4A-5nd1A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF07361
(Cytochrom_B562) 		6 LEU A2093
LEU A2013
VAL A2015
ILE A2071
ALA A2028
LEU A2075
 None
 1.50A 2qb4A-5ndzA:
2.2		 2qb4A-5ndzA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 LEU B 107
LEU B 105
ALA B 172
LEU B 183
ASP B 179
 None
 1.12A 2qb4A-5of4B:
undetectable		 2qb4A-5of4B:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 205
GLN A 211
ILE A 146
PHE A 244
LEU A 158
 None
 0.93A 2qb4A-5opjA:
undetectable		 2qb4A-5opjA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 2
CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 5 LEU C 529
LEU C 528
ILE A 631
ALA A 624
ASP A 584
 None
 1.04A 2qb4A-5oqrC:
undetectable		 2qb4A-5oqrC:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szp PROTOCADHERIN GAMMA
B7

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 LEU A 110
ILE A 200
PHE A 148
LEU A 170
ASP A 116
 None
 1.14A 2qb4A-5szpA:
undetectable		 2qb4A-5szpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 5 LEU B  90
LEU B  87
ILE B  47
LEU B 316
ASP B 315
 None
 1.13A 2qb4A-5thzB:
undetectable		 2qb4A-5thzB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 6 LEU A 398
VAL A 413
ILE A 401
ALA A 368
PHE A 367
LEU A 324
 None
 1.44A 2qb4A-5w21A:
undetectable		 2qb4A-5w21A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5f TAIL TUBE PROTEIN
GP19

(Enterobacteria
phage T4 sensu
lato) 		PF06841
(Phage_T4_gp19) 		5 LEU A 132
LEU A 157
VAL A 137
GLN A  89
ILE A  25
 None
 1.16A 2qb4A-5w5fA:
undetectable		 2qb4A-5w5fA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcb PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 5 LEU A  95
ILE A  92
ALA A 104
PHE A 103
LEU A  57
 None
 1.15A 2qb4A-5xcbA:
undetectable		 2qb4A-5xcbA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 LEU A 527
LEU A 556
ILE A 487
ALA A 560
PHE A 485
 None
 1.04A 2qb4A-5yj6A:
undetectable		 2qb4A-5yj6A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7j 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Vibrio cholerae) 		no annotation 5 ARG A   5
ILE A  40
PHE A  93
LEU A  13
ASP A  12
 None
 1.04A 2qb4A-6b7jA:
undetectable		 2qb4A-6b7jA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 5 LEU A 109
ARG A 107
ILE A 121
ALA A  62
PHE A  20
 None
 1.10A 2qb4A-6brmA:
undetectable		 2qb4A-6brmA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 5 LEU A  96
LEU A  95
ARG A  97
PHE A  60
ASP A 101
 None
 1.13A 2qb4A-6d95A:
undetectable		 2qb4A-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 5 LEU A 370
LEU A 101
ALA A 164
PHE A 102
LEU A 158
 None
NAD  A 502 (-4.6A)
None
None
None
 1.11A 2qb4A-6dftA:
undetectable		 2qb4A-6dftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z UPF0434 FAMILY
PROTEIN

(Haloferax
volcanii) 		no annotation 5 LEU C  20
LEU C  35
ARG C  34
ILE C  30
ASP C  23
 GOL  C 101 (-4.4A)
GOL  C 101 (-4.8A)
None
None
None
 1.15A 2qb4A-6f5zC:
undetectable		 2qb4A-6f5zC:
8.84