SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q7L_A_TESA155_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a76 FLAP ENDONUCLEASE-1
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ASN A  30
GLY A  28
TRP A  77
MET A 131
THR A 189
 None
 1.18A 2q7lA-1a76A:
undetectable		 2q7lA-1a76A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aos ARGININOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 LEU A 180
LEU A 136
VAL A 342
MET A 339
MET A 256
 None
 1.40A 2q7lA-1aosA:
undetectable		 2q7lA-1aosA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9k ADENOSYLCOBINAMIDE
KINASE

(Salmonella
enterica) 		PF02283
(CobU) 		5 LEU A  89
ASN A  88
LEU A  90
VAL A 157
THR A  31
 None
None
None
None
5GP  A 604 (-4.6A)
 1.32A 2q7lA-1c9kA:
undetectable		 2q7lA-1c9kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3b PROTEIN (SMALL
NUCLEAR
RIBONUCLEOPROTEIN
ASSOCIATED PROTEIN
B)

(Homo sapiens) 		PF01423
(LSM) 		5 LEU B  21
ASN B  76
LEU B  77
GLY B  74
VAL B  70
 GOL  B 608 ( 4.5A)
GOL  B 608 (-3.3A)
CIT  B 702 (-4.4A)
None
None
 1.31A 2q7lA-1d3bB:
undetectable		 2q7lA-1d3bB:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo1 HYPOTHETICAL PROTEIN
MTH1175

(Methanothermobacter
thermautotrophicus) 		PF02579
(Nitro_FeMo-Co) 		5 LEU A  82
ASN A  83
LEU A  85
GLY A  86
VAL A  66
 None
 1.16A 2q7lA-1eo1A:
undetectable		 2q7lA-1eo1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlb HEMOGLOBIN (DEOXY)

(Molpadia
arenicola) 		PF00042
(Globin) 		5 LEU A  97
LEU A  96
VAL A  77
MET A  81
THR A 103
 None
None
HEM  A 158 ( 4.1A)
HEM  A 158 ( 4.8A)
HEM  A 158 (-3.2A)
 1.03A 2q7lA-1hlbA:
undetectable		 2q7lA-1hlbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdi L-RIBULOSE 5
PHOSPHATE
4-EPIMERASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		5 LEU A 167
GLY A 108
GLN A 109
ARG A 201
THR A 152
 None
 1.31A 2q7lA-1jdiA:
undetectable		 2q7lA-1jdiA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE

(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A 230
LEU A 229
GLN A 199
VAL A 226
ARG A 284
 None
None
BR  A2008 (-4.0A)
None
None
 1.46A 2q7lA-1jhdA:
undetectable		 2q7lA-1jhdA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 247
LEU A 244
GLY A 245
MET A 232
THR A 224
 None
 1.33A 2q7lA-1mdfA:
undetectable		 2q7lA-1mdfA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		5 LEU A 118
ASN A 119
LEU A  29
GLY A  30
MET A  39
 None
 1.23A 2q7lA-1o9iA:
undetectable		 2q7lA-1o9iA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		5 LEU A 118
ASN A 119
LEU A  29
GLY A  30
MET A  67
 None
 1.17A 2q7lA-1o9iA:
undetectable		 2q7lA-1o9iA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
TRP A 383
ARG A 394
MET A 421
 EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
None
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.73A 2q7lA-1pcgA:
27.4		 2q7lA-1pcgA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A  63
ASN A  64
LEU A  67
GLY A  71
MET A  91
 None
 1.30A 2q7lA-1qpoA:
undetectable		 2q7lA-1qpoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  21
LEU A  22
MET A 115
VAL A 113
THR A 226
 None
 1.20A 2q7lA-1tqhA:
undetectable		 2q7lA-1tqhA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  22
GLY A  96
MET A 115
VAL A 113
THR A 226
 None
 1.23A 2q7lA-1tqhA:
undetectable		 2q7lA-1tqhA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 324
LEU A 327
TRP A 361
MET A 362
VAL A 366
ARG A 372
 None
 0.64A 2q7lA-1xb7A:
26.7		 2q7lA-1xb7A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HSPBP1 PROTEIN

(Homo sapiens) 		PF08609
(Fes1) 		5 LEU A 344
LEU A 293
GLY A 294
VAL A 274
THR A 301
 None
 1.13A 2q7lA-1xqsA:
undetectable		 2q7lA-1xqsA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2f CELL DIVISION
PROTEIN ZIPA

(Escherichia
coli) 		PF04354
(ZipA_C) 		5 LEU A  23
ASN A  24
LEU A  28
VAL A  65
MET A  64
 None
 1.36A 2q7lA-1y2fA:
undetectable		 2q7lA-1y2fA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2f CELL DIVISION
PROTEIN ZIPA

(Escherichia
coli) 		PF04354
(ZipA_C) 		5 LEU A  23
LEU A  28
GLY A  25
VAL A  65
MET A  64
 None
 1.28A 2q7lA-1y2fA:
undetectable		 2q7lA-1y2fA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 704
ASN A 705
LEU A 707
GLY A 708
GLN A 711
MET A 742
VAL A 746
MET A 749
ARG A 752
MET A 780
THR A 877
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-3.0A)
 0.47A 2q7lA-2ax9A:
41.2		 2q7lA-2ax9A:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 704
ASN A 705
TRP A 741
MET A 742
VAL A 746
MET A 780
THR A 877
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
None
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-3.0A)
 1.07A 2q7lA-2ax9A:
41.2		 2q7lA-2ax9A:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		5 LEU A 198
LEU A 195
GLY A 193
VAL A 218
THR A 228
 None
 1.32A 2q7lA-2cdaA:
undetectable		 2q7lA-2cdaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ASN A 226
LEU A 228
GLY A 229
MET A 261
THR A 257
 None
 1.33A 2q7lA-2d3lA:
undetectable		 2q7lA-2d3lA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 281
GLY A 280
VAL A 273
ARG A 363
THR A  95
 None
 1.02A 2q7lA-2de2A:
undetectable		 2q7lA-2de2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 268
LEU A 271
TRP A 305
MET A 306
ARG A 316
 OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
None
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
 0.72A 2q7lA-2gpvA:
25.9		 2q7lA-2gpvA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho0 REPRESSOR PROTEIN
CI101-229DM-K192A

(Escherichia
coli) 		PF00717
(Peptidase_S24) 		5 LEU A 194
GLY A 177
VAL A 225
MET A 150
THR A 158
 None
 1.48A 2q7lA-2ho0A:
undetectable		 2q7lA-2ho0A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
TRP A 383
ARG A 394
MET A 421
 EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
None
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.78A 2q7lA-2ocfA:
28.9		 2q7lA-2ocfA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		5 LEU A  72
ASN A  73
LEU A  75
GLY A  76
VAL A 121
 None
 0.99A 2q7lA-2ozkA:
undetectable		 2q7lA-2ozkA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 108
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
 0.39A 2q7lA-2q3yA:
37.8		 2q7lA-2q3yA:
59.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		5 LEU A 167
LEU A 168
GLY A 169
MET A 146
THR A 139
 None
 1.48A 2q7lA-2qmiA:
undetectable		 2q7lA-2qmiA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra8 UNCHARACTERIZED
PROTEIN Q64V53_BACFR

(Bacteroides
fragilis) 		PF05406
(WGR) 		5 LEU A 177
ASN A 176
LEU A 195
MET A 171
VAL A 167
 None
 1.42A 2q7lA-2ra8A:
undetectable		 2q7lA-2ra8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		5 LEU A 800
ASN A 907
LEU A 801
GLY A 802
MET A 839
 None
 1.33A 2q7lA-2x6kA:
undetectable		 2q7lA-2x6kA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 464
LEU A 466
GLY A 467
VAL A 429
ARG A 381
 None
 1.25A 2q7lA-2y8nA:
undetectable		 2q7lA-2y8nA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		5 LEU A 299
ASN A 300
LEU A 302
GLY A 303
THR A 309
 None
 1.05A 2q7lA-3blwA:
undetectable		 2q7lA-3blwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 342
ASN A 343
LEU A 388
GLY A 389
VAL A 289
 None
 1.47A 2q7lA-3cgdA:
undetectable		 2q7lA-3cgdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cit SENSOR HISTIDINE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 LEU A 129
LEU A  51
GLY A  63
MET A  60
VAL A  58
 None
 1.49A 2q7lA-3citA:
undetectable		 2q7lA-3citA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2

(Escherichia
coli) 		PF00730
(HhH-GPD)
PF06029
(AlkA_N) 		5 LEU A 182
LEU A 185
GLY A 117
MET A 174
THR A 135
 None
 1.44A 2q7lA-3cwuA:
undetectable		 2q7lA-3cwuA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE

(Lactobacillus
delbrueckii) 		PF00155
(Aminotran_1_2) 		5 LEU A 322
ASN A 170
GLY A 173
VAL A 325
ARG A 302
 None
LLP  A 233 ( 3.9A)
None
None
PEG  A 397 (-4.1A)
 1.39A 2q7lA-3dzzA:
undetectable		 2q7lA-3dzzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0f PUTATIVE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bifidobacterium
adolescentis) 		PF02811
(PHP) 		5 LEU A 213
LEU A 212
GLY A 204
GLN A 240
MET A 221
 None
 1.41A 2q7lA-3e0fA:
undetectable		 2q7lA-3e0fA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		5 LEU A 432
ASN A 353
GLY A 354
MET A 380
MET A 394
 None
 1.45A 2q7lA-3g0tA:
undetectable		 2q7lA-3g0tA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 718
ASN A 719
LEU A 721
GLY A 722
GLN A 725
MET A 756
VAL A 760
ARG A 766
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
 0.51A 2q7lA-3kbaA:
35.3		 2q7lA-3kbaA:
53.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 LEU E 479
LEU E 480
GLY E 481
VAL E 434
THR E 456
 None
 1.45A 2q7lA-3kdsE:
2.1		 2q7lA-3kdsE:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 112
ASN A 125
MET A 473
VAL A 502
MET A 517
 None
 1.33A 2q7lA-3ljpA:
undetectable		 2q7lA-3ljpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		5 LEU A  74
GLN A 124
VAL A  82
ARG A 128
THR A  35
 None
 1.20A 2q7lA-3m1aA:
undetectable		 2q7lA-3m1aA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3og5 OUTER MEMBRANE
PROTEIN ASSEMBLY
COMPLEX, YAET
PROTEIN

(Escherichia
coli) 		PF07244
(POTRA) 		5 LEU A 389
ASN A 390
LEU A 392
GLY A 393
THR A 397
 None
 1.27A 2q7lA-3og5A:
undetectable		 2q7lA-3og5A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		5 LEU A 100
LEU A 103
GLY A 104
GLN A 107
MET A 295
 None
 1.13A 2q7lA-3opsA:
undetectable		 2q7lA-3opsA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfi HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Campylobacter
jejuni) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		5 LEU A 248
ASN A 249
LEU A 251
GLY A 252
ARG A 222
 None
 0.98A 2q7lA-3pfiA:
undetectable		 2q7lA-3pfiA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
GLN A  39
TRP A  69
ARG A  80
 1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.5A)
 1.35A 2q7lA-3ry9A:
36.7		 2q7lA-3ry9A:
53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 108
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
 0.59A 2q7lA-3ry9A:
36.7		 2q7lA-3ry9A:
53.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5i FERROUS IRON
TRANSPORT PROTEIN B

(Gallionella
capsiferriformans) 		PF02421
(FeoB_N) 		5 LEU A   6
LEU A   7
GLY A   8
VAL A 110
MET A  21
 None
 1.35A 2q7lA-3w5iA:
undetectable		 2q7lA-3w5iA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		5 LEU B 154
ASN B 155
GLY B 158
GLN B 161
VAL B 225
 None
 1.11A 2q7lA-3ze7B:
undetectable		 2q7lA-3ze7B:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 421
LEU A 385
GLY A 386
GLN A 427
VAL A 302
 None
 1.22A 2q7lA-4bjpA:
undetectable		 2q7lA-4bjpA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn2 KINESIN-LIKE PROTEIN
KIF15

(Homo sapiens) 		PF00225
(Kinesin) 		5 LEU A 246
ASN A  88
LEU A 247
GLY A  89
VAL A 250
 None
 1.28A 2q7lA-4bn2A:
undetectable		 2q7lA-4bn2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ASN A 421
LEU A 423
GLY A 420
VAL A 446
THR A 381
 None
 1.05A 2q7lA-4cokA:
undetectable		 2q7lA-4cokA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF05292
(MCD)
PF17408
(MCD_N) 		5 LEU A 157
TRP A 189
MET A 185
VAL A 181
MET A 178
 None
 1.49A 2q7lA-4f0xA:
undetectable		 2q7lA-4f0xA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		5 LEU A 482
GLY A 485
GLN A 484
VAL A 399
THR A 468
 None
 1.24A 2q7lA-4f3eA:
undetectable		 2q7lA-4f3eA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 135
ASN A 131
GLY A 155
GLN A 153
ARG A 151
 None
None
None
None
CL  A 404 (-3.5A)
 1.43A 2q7lA-4hnlA:
undetectable		 2q7lA-4hnlA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		5 GLY A 328
GLN A 327
MET A 347
VAL A 351
MET A 261
 None
 1.11A 2q7lA-4iwhA:
undetectable		 2q7lA-4iwhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		5 GLY A 328
GLN A 327
VAL A 351
MET A 261
THR A 331
 None
 1.38A 2q7lA-4iwhA:
undetectable		 2q7lA-4iwhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.42A 2q7lA-4j1yA:
undetectable		 2q7lA-4j1yA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		5 LEU A 191
ASN A 190
LEU A 195
GLY A 194
ARG A 320
 None
 1.42A 2q7lA-4j72A:
undetectable		 2q7lA-4j72A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 5 LEU A  56
LEU A  57
GLY A  54
GLN A 171
MET A 293
 None
 1.27A 2q7lA-4jw1A:
undetectable		 2q7lA-4jw1A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc3 INTERLEUKIN-1
RECEPTOR-LIKE 1
INTERLEUKIN-33

(Homo sapiens) 		PF07679
(I-set)
PF15095
(IL33) 		5 LEU B 306
ASN B 307
LEU B 311
GLY B 310
VAL A 184
 None
 1.26A 2q7lA-4kc3B:
undetectable		 2q7lA-4kc3B:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		5 LEU A 378
ASN A 379
LEU A 381
GLY A 380
MET A 432
 None
 1.31A 2q7lA-4n0rA:
undetectable		 2q7lA-4n0rA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 283
LEU A 286
TRP A 320
MET A 321
ARG A 331
MET A 358
 None
 0.76A 2q7lA-4n1yA:
28.9		 2q7lA-4n1yA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 LEU A 345
ASN A 346
LEU A 348
GLY A 349
THR A 352
 None
 1.12A 2q7lA-4nfuA:
undetectable		 2q7lA-4nfuA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzp ARGININOSUCCINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00764
(Arginosuc_synth) 		5 LEU A 250
ASN A 251
LEU A 253
VAL A 354
THR A 280
 None
 1.29A 2q7lA-4nzpA:
undetectable		 2q7lA-4nzpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2l GTP-BINDING PROTEIN
RHEB

(Mus musculus) 		PF00071
(Ras) 		5 LEU A  83
LEU A  12
GLY A  13
GLN A  64
VAL A  98
 None
 1.40A 2q7lA-4o2lA:
undetectable		 2q7lA-4o2lA:
18.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 563
ASN A 564
LEU A 566
GLY A 567
GLN A 570
TRP A 600
MET A 601
ARG A 611
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
 0.79A 2q7lA-4p6wA:
33.4		 2q7lA-4p6wA:
50.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe8 TAT-LINKED QUALITY
CONTROL PROTEIN TATD

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 LEU A 198
LEU A 199
GLY A 172
MET A 161
VAL A 165
 None
 1.36A 2q7lA-4pe8A:
undetectable		 2q7lA-4pe8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmj PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF00248
(Aldo_ket_red) 		5 LEU A  40
LEU A  44
GLY A  43
MET A  26
THR A 240
 None
None
None
None
NAP  A 301 (-3.7A)
 1.45A 2q7lA-4pmjA:
undetectable		 2q7lA-4pmjA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 ASN A 176
GLY A 179
GLN A 180
VAL A 182
ARG A 146
 None
 1.35A 2q7lA-4raeA:
undetectable		 2q7lA-4raeA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 769
ASN A 770
LEU A 772
GLN A 776
TRP A 806
MET A 807
ARG A 817
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
 0.69A 2q7lA-4udbA:
33.9		 2q7lA-4udbA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 LEU A 602
ASN A 603
LEU A 605
VAL A 667
MET A 637
 None
 1.39A 2q7lA-5affA:
undetectable		 2q7lA-5affA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikk HISTONE DEACETYLASE
CLR3

(Schizosaccharomyces
pombe) 		PF00850
(Hist_deacetyl)
PF09757
(Arb2) 		5 LEU A 587
ASN A 586
LEU A 584
GLY A 583
VAL A 559
 None
 1.41A 2q7lA-5ikkA:
undetectable		 2q7lA-5ikkA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 5 LEU B 167
LEU B 170
GLY B 169
VAL B 154
THR B 159
 None
 1.50A 2q7lA-5kisB:
undetectable		 2q7lA-5kisB:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		5 LEU A 110
ASN A 111
LEU A 122
GLY A 121
GLN A 152
 None
None
None
CA  A 501 ( 4.9A)
CA  A 501 (-2.7A)
 1.42A 2q7lA-5ldtA:
undetectable		 2q7lA-5ldtA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly3 ACTIN/ACTIN FAMILY
PROTEIN

(Pyrobaculum
calidifontis) 		PF00022
(Actin) 		5 ASN A 336
LEU A 201
GLY A 200
VAL A 180
MET A 324
 None
 1.07A 2q7lA-5ly3A:
undetectable		 2q7lA-5ly3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 5 ASN A 281
LEU A 299
GLY A 298
GLN A 320
MET A 118
 None
 1.43A 2q7lA-5mhfA:
undetectable		 2q7lA-5mhfA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms7 LEGIONELLA
PNEUMOPHILA EFFECTOR
PROTEIN RAVZ

(Legionella
pneumophila) 		no annotation 5 LEU A 410
LEU A 413
GLY A 414
VAL A 422
MET A 398
 None
 1.48A 2q7lA-5ms7A:
undetectable		 2q7lA-5ms7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN A 770
GLY A 774
GLN A 776
TRP A 806
ARG A 817
 ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
 1.44A 2q7lA-5mwpA:
37.2		 2q7lA-5mwpA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 LEU A 769
ASN A 770
LEU A 772
GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 845
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
 0.59A 2q7lA-5mwpA:
37.2		 2q7lA-5mwpA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 5 LEU A 463
GLY A 465
GLN A 176
VAL A 169
MET A 410
 None
 1.19A 2q7lA-5oc1A:
undetectable		 2q7lA-5oc1A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 5 LEU A 404
LEU A 359
GLY A 408
GLN A 411
VAL A 383
 None
 1.44A 2q7lA-5oieA:
undetectable		 2q7lA-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 298
LEU A 301
TRP A 335
MET A 336
ARG A 346
 EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
None
EST  A 601 ( 3.7A)
EST  A 601 (-4.1A)
 0.51A 2q7lA-5toaA:
26.4		 2q7lA-5toaA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 5 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.42A 2q7lA-5ubmA:
undetectable		 2q7lA-5ubmA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
GLY A 563
GLN A 566
MET A 597
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
 0.82A 2q7lA-5uc1A:
23.3		 2q7lA-5uc1A:
48.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 LEU A 559
ASN A 560
LEU A 562
GLY A 563
GLN A 566
ARG A 607
MET A 635
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 1.09A 2q7lA-5uc1A:
23.3		 2q7lA-5uc1A:
48.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF17207
(MCM_OB) 		5 MET 3 462
VAL 3 489
MET 3 490
MET 3 478
THR 3 432
 None
 1.45A 2q7lA-5udb3:
undetectable		 2q7lA-5udb3:
13.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
GLN A  39
TRP A  69
MET A  70
 1TA  A 301 (-3.0A)
None
1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
 1.30A 2q7lA-5ufsA:
35.5		 2q7lA-5ufsA:
53.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLN A  39
ARG A  80
MET A 108
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
 1.02A 2q7lA-5ufsA:
35.5		 2q7lA-5ufsA:
53.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
 0.73A 2q7lA-5ufsA:
35.5		 2q7lA-5ufsA:
53.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxi EARP

(Neisseria
meningitidis) 		no annotation 5 GLY A  22
GLN A 252
VAL A  30
MET A 142
THR A  90
 TRH  A 401 ( 4.0A)
TRH  A 401 ( 4.0A)
None
None
None
 1.33A 2q7lA-5wxiA:
undetectable		 2q7lA-5wxiA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		5 LEU C 184
ASN C 187
LEU C 188
GLY A 353
VAL C  84
 None
 1.24A 2q7lA-5xbpC:
undetectable		 2q7lA-5xbpC:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 LEU A 345
ASN A 344
LEU A 342
GLY A 341
ARG A 272
 None
 1.40A 2q7lA-5yvsA:
undetectable		 2q7lA-5yvsA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 LEU A 733
LEU A 698
GLY A 728
VAL A 644
MET A 645
 None
 1.10A 2q7lA-6a91A:
undetectable		 2q7lA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6geb DOTB

(Legionella
pneumophila) 		no annotation 5 LEU A  65
ASN A  62
LEU A  60
MET A  21
THR A  78
 None
 1.46A 2q7lA-6gebA:
undetectable		 2q7lA-6gebA:
14.40