SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q7K_A_TESA304

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9k ADENOSYLCOBINAMIDE
KINASE

(Salmonella
enterica) 		PF02283
(CobU) 		5 LEU A  89
ASN A  88
LEU A  90
VAL A 157
THR A  31
 None
None
None
None
5GP  A 604 (-4.6A)
 1.33A 2q7kA-1c9kA:
undetectable		 2q7kA-1c9kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkd GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 LEU A 247
LEU A 248
VAL A 254
LEU A 262
THR A 266
 None
 1.25A 2q7kA-1dkdA:
undetectable		 2q7kA-1dkdA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 456
LEU A 517
VAL A 657
MET A 661
THR A 651
 None
 1.35A 2q7kA-1elvA:
undetectable		 2q7kA-1elvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlb HEMOGLOBIN (DEOXY)

(Molpadia
arenicola) 		PF00042
(Globin) 		5 LEU A  97
LEU A  96
VAL A  77
MET A  81
THR A 103
 None
None
HEM  A 158 ( 4.1A)
HEM  A 158 ( 4.8A)
HEM  A 158 (-3.2A)
 1.04A 2q7kA-1hlbA:
undetectable		 2q7kA-1hlbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la1 GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		5 LEU A 247
LEU A 248
VAL A 254
LEU A 262
THR A 266
 None
 1.31A 2q7kA-1la1A:
undetectable		 2q7kA-1la1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 LEU A 392
GLN A 531
VAL A 528
LEU A 522
THR A 520
 None
 1.12A 2q7kA-1lq2A:
undetectable		 2q7kA-1lq2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mho S-100 PROTEIN

(Bos taurus) 		PF00036
(EF-hand_1)
PF01023
(S_100) 		5 LEU A  35
LEU A  32
MET A  74
VAL A  77
LEU A  10
 None
 1.43A 2q7kA-1mhoA:
undetectable		 2q7kA-1mhoA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nqb SINGLE-CHAIN
ANTIBODY FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 LEU A 198
GLN A 138
VAL A 203
LEU A 229
THR A 227
 None
 1.45A 2q7kA-1nqbA:
undetectable		 2q7kA-1nqbA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi4 HYPOTHETICAL PROTEIN
YHBO

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		5 LEU A  92
LEU A 130
VAL A 136
LEU A 171
THR A 173
 None
 1.39A 2q7kA-1oi4A:
undetectable		 2q7kA-1oi4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 LEU A 213
LEU A 210
GLN A 206
VAL A 592
LEU A  82
 None
 1.30A 2q7kA-1su7A:
undetectable		 2q7kA-1su7A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 LEU A  21
LEU A  22
MET A 115
VAL A 113
THR A 226
 None
 1.18A 2q7kA-1tqhA:
undetectable		 2q7kA-1tqhA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
LEU A 327
MET A 362
VAL A 366
ARG A 372
 None
 0.50A 2q7kA-1xb7A:
26.6		 2q7kA-1xb7A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y2f CELL DIVISION
PROTEIN ZIPA

(Escherichia
coli) 		PF04354
(ZipA_C) 		5 LEU A  23
ASN A  24
LEU A  28
VAL A  65
MET A  64
 None
 1.34A 2q7kA-1y2fA:
undetectable		 2q7kA-1y2fA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yii ANNEXIN A5

(Gallus gallus) 		PF00191
(Annexin) 		5 LEU A 312
LEU A 315
VAL A 272
MET A 259
LEU A 255
 None
 1.31A 2q7kA-1yiiA:
undetectable		 2q7kA-1yiiA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zdv OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF13954
(PapC_N) 		5 LEU A 111
ASN A 112
LEU A 104
LEU A  93
THR A 114
 None
 1.39A 2q7kA-1zdvA:
undetectable		 2q7kA-1zdvA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		5 LEU B2288
ASN B2289
LEU B2261
VAL B2274
LEU B2297
 None
 1.38A 2q7kA-2assB:
undetectable		 2q7kA-2assB:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
VAL A 746
MET A 749
ARG A 752
MET A 780
LEU A 873
THR A 877
MET A 895
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.0A)
None
 0.55A 2q7kA-2ax9A:
41.7		 2q7kA-2ax9A:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE

(Musca domestica) 		PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes) 		5 LEU A 141
LEU A 140
MET A 120
LEU A 147
THR A 146
 None
 1.30A 2q7kA-2bw3A:
undetectable		 2q7kA-2bw3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE

(Musca domestica) 		PF10683
(DBD_Tnp_Hermes) 		5 LEU B 141
LEU B 140
MET B 120
LEU B 147
THR B 146
 None
 1.21A 2q7kA-2bw3B:
undetectable		 2q7kA-2bw3B:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1o IGK-C PROTEIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU A  37
LEU A  47
VAL A  78
LEU A 104
THR A 102
 None
 1.36A 2q7kA-2c1oA:
undetectable		 2q7kA-2c1oA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2do8 UPF0301 PROTEIN
HD_1794

([Haemophilus]
ducreyi) 		PF02622
(DUF179) 		5 GLN A  70
VAL A  72
ARG A  23
LEU A  52
THR A  54
 None
 1.22A 2q7kA-2do8A:
undetectable		 2q7kA-2do8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1a 75AA LONG
HYPOTHETICAL
REGULATORY PROTEIN
ASNC

(Pyrococcus
horikoshii) 		PF01037
(AsnC_trans_reg) 		5 LEU A  52
MET A  25
VAL A  28
MET A   8
LEU A  22
 None
 1.44A 2q7kA-2e1aA:
undetectable		 2q7kA-2e1aA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lci PROTEIN OR36

(synthetic
construct) 		no annotation 5 LEU A  82
ASN A   8
LEU A  81
VAL A  78
LEU A  68
 None
 1.45A 2q7kA-2lciA:
undetectable		 2q7kA-2lciA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkm MORTALITY FACTOR
4-LIKE PROTEIN 1

(Homo sapiens) 		PF05712
(MRG) 		5 LEU B 234
LEU B 233
VAL B 257
MET B 254
LEU B 184
 None
 1.14A 2q7kA-2lkmB:
undetectable		 2q7kA-2lkmB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER
ATP-BINDING PROTEIN
HI1470

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		5 LEU C 170
VAL C 182
MET C 180
LEU C 152
THR C 156
 None
 1.26A 2q7kA-2nq2C:
undetectable		 2q7kA-2nq2C:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		5 LEU A 204
VAL A 236
ARG A 241
LEU A 228
THR A 161
 None
 1.41A 2q7kA-2p4zA:
undetectable		 2q7kA-2p4zA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 108
LEU A 201
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 ( 4.2A)
 0.54A 2q7kA-2q3yA:
37.4		 2q7kA-2q3yA:
59.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra8 UNCHARACTERIZED
PROTEIN Q64V53_BACFR

(Bacteroides
fragilis) 		PF05406
(WGR) 		5 LEU A 177
ASN A 176
LEU A 195
MET A 171
VAL A 167
 None
 1.39A 2q7kA-2ra8A:
undetectable		 2q7kA-2ra8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs9 PEREGRIN

(Homo sapiens) 		PF00439
(Bromodomain) 		5 LEU B  52
LEU B  51
GLN B 150
VAL B 143
LEU B  59
 None
 1.38A 2q7kA-2rs9B:
undetectable		 2q7kA-2rs9B:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 LEU A 394
GLN A 147
VAL A 413
LEU A 421
THR A 376
 None
None
GOL  A1561 ( 4.3A)
None
None
 1.30A 2q7kA-2v7gA:
undetectable		 2q7kA-2v7gA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 LEU A 353
GLN A 349
VAL A 273
MET A 427
LEU A 271
 None
UDP  A1477 (-3.3A)
None
None
None
 1.33A 2q7kA-2vg8A:
undetectable		 2q7kA-2vg8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7q OUTER-MEMBRANE
LIPOPROTEIN CARRIER
PROTEIN

(Pseudomonas
aeruginosa) 		PF03548
(LolA) 		5 LEU A  30
ASN A  31
LEU A  29
MET A 182
LEU A  36
 None
 1.45A 2q7kA-2w7qA:
undetectable		 2q7kA-2w7qA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 LEU A 759
ASN A 763
LEU A 760
VAL A 367
THR A 769
 None
 1.23A 2q7kA-2yn9A:
undetectable		 2q7kA-2yn9A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 3

(Homo sapiens) 		PF04882
(Peroxin-3) 		5 LEU A 264
ASN A 265
LEU A 263
VAL A 131
LEU A 271
 None
 1.06A 2q7kA-3ajbA:
undetectable		 2q7kA-3ajbA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 3

(Homo sapiens) 		PF04882
(Peroxin-3) 		5 LEU A 264
ASN A 265
VAL A 131
MET A 239
LEU A 271
 None
 1.15A 2q7kA-3ajbA:
undetectable		 2q7kA-3ajbA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkp CYCLOPHILIN

(Toxoplasma
gondii) 		PF00160
(Pro_isomerase) 		5 LEU A 166
LEU A 163
VAL A  35
LEU A  26
THR A  28
 None
 1.16A 2q7kA-3bkpA:
undetectable		 2q7kA-3bkpA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 LEU A  59
VAL A 106
MET A  33
MET A  97
LEU A 104
 None
 1.26A 2q7kA-3e3xA:
undetectable		 2q7kA-3e3xA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		PF00616
(RasGAP) 		5 LEU A1190
ASN A1189
LEU A1191
VAL A1166
LEU A1030
 None
 1.41A 2q7kA-3fayA:
undetectable		 2q7kA-3fayA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Mus musculus) 		PF00155
(Aminotran_1_2) 		5 MET A  60
VAL A 400
MET A 402
LEU A 421
THR A 414
 None
 1.44A 2q7kA-3hlmA:
undetectable		 2q7kA-3hlmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 5 LEU B 251
LEU B 252
VAL B 258
LEU B1061
THR B1063
 None
 1.45A 2q7kA-3iz3B:
undetectable		 2q7kA-3iz3B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A  56
VAL A  44
MET A  45
LEU A 119
THR A 115
 None
None
None
MPD  A 505 ( 4.3A)
None
 1.06A 2q7kA-3jv7A:
undetectable		 2q7kA-3jv7A:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 719
LEU A 721
GLN A 725
MET A 756
VAL A 760
ARG A 766
LEU A 887
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
 0.71A 2q7kA-3kbaA:
34.9		 2q7kA-3kbaA:
53.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 718
ASN A 719
LEU A 721
GLN A 725
MET A 756
VAL A 760
ARG A 766
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
 0.56A 2q7kA-3kbaA:
34.9		 2q7kA-3kbaA:
53.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 718
ASN A 719
LEU A 721
MET A 756
MET A 909
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
None
 1.09A 2q7kA-3kbaA:
34.9		 2q7kA-3kbaA:
53.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 ASN A 335
LEU A 392
VAL A 423
LEU A 425
THR A 431
 None
 1.32A 2q7kA-3khkA:
undetectable		 2q7kA-3khkA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxy EXOENZYME S
SYNTHESIS PROTEIN C

(Pseudomonas
aeruginosa) 		PF05932
(CesT) 		5 LEU A  52
LEU A  44
VAL A  41
LEU A 115
THR A 114
 None
 1.37A 2q7kA-3kxyA:
undetectable		 2q7kA-3kxyA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 112
ASN A 125
MET A 473
VAL A 502
MET A 517
 None
 1.35A 2q7kA-3ljpA:
undetectable		 2q7kA-3ljpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		5 LEU A 409
LEU A 413
MET A 224
VAL A 198
LEU A 212
 None
 1.39A 2q7kA-3mveA:
undetectable		 2q7kA-3mveA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 LEU A 397
LEU A 453
VAL A 429
LEU A 460
THR A 394
 None
 1.44A 2q7kA-3pigA:
undetectable		 2q7kA-3pigA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt8 HEMOGLOBIN III

(Phacoides
pectinatus) 		PF00042
(Globin) 		5 LEU B 119
VAL B  78
MET B  74
LEU B  12
THR B 129
 None
 1.42A 2q7kA-3pt8B:
undetectable		 2q7kA-3pt8B:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 108
LEU A 201
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.61A 2q7kA-3ry9A:
37.1		 2q7kA-3ry9A:
53.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  67
LEU A  70
VAL A  41
ARG A  43
MET A  75
 None
 1.24A 2q7kA-3sf6A:
undetectable		 2q7kA-3sf6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tyt HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN L

(Mus musculus) 		PF13893
(RRM_5) 		5 LEU A 553
LEU A 556
MET A 391
VAL A 396
LEU A 386
 None
 1.06A 2q7kA-3tytA:
undetectable		 2q7kA-3tytA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		5 LEU A 840
ASN A 841
VAL A 796
MET A 800
LEU A 819
 None
 1.25A 2q7kA-3un9A:
undetectable		 2q7kA-3un9A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		5 LEU A 140
ASN A 142
LEU A 141
VAL A   7
LEU A 108
 None
 1.28A 2q7kA-3w77A:
undetectable		 2q7kA-3w77A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbd SINGLE CHAIN FV
FRAGMENT OF MAB735

(Mus musculus) 		PF07686
(V-set) 		5 LEU A  78
GLN A  18
VAL A  83
LEU A 109
THR A 107
 None
 1.45A 2q7kA-3wbdA:
undetectable		 2q7kA-3wbdA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh3 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER E

(Homo sapiens) 		PF00059
(Lectin_C) 		5 ASN A 119
GLN A 121
ARG A 189
LEU A 158
THR A 156
 CA  A 501 (-3.4A)
None
None
None
None
 1.08A 2q7kA-3wh3A:
undetectable		 2q7kA-3wh3A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 LEU A 670
LEU A 669
VAL A 661
LEU A 334
THR A 332
 None
 1.24A 2q7kA-4bejA:
undetectable		 2q7kA-4bejA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 GLN A 118
VAL A  96
MET A 100
MET A 717
THR A 195
 None
 1.33A 2q7kA-4bevA:
undetectable		 2q7kA-4bevA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn2 KINESIN-LIKE PROTEIN
KIF15

(Homo sapiens) 		PF00225
(Kinesin) 		5 LEU A 246
ASN A  88
LEU A 247
VAL A 225
LEU A 309
 None
 1.19A 2q7kA-4bn2A:
undetectable		 2q7kA-4bn2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn2 KINESIN-LIKE PROTEIN
KIF15

(Homo sapiens) 		PF00225
(Kinesin) 		5 LEU A 246
ASN A  88
LEU A 247
VAL A 250
LEU A 310
 None
 1.28A 2q7kA-4bn2A:
undetectable		 2q7kA-4bn2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cym ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU D 516
LEU D 513
GLN D 509
VAL D 545
LEU D 533
 None
 1.40A 2q7kA-4cymD:
undetectable		 2q7kA-4cymD:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU A 107
ASN A 108
LEU A 106
VAL A  86
LEU A 114
 None
 1.12A 2q7kA-4fgvA:
undetectable		 2q7kA-4fgvA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		5 LEU A 325
GLN A 327
VAL A 351
MET A 261
THR A 331
 None
 1.33A 2q7kA-4iwhA:
undetectable		 2q7kA-4iwhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.42A 2q7kA-4j1yA:
undetectable		 2q7kA-4j1yA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE

(Brucella
melitensis) 		no annotation 5 ASN A  10
LEU A 274
VAL A  26
LEU A  35
THR A  38
 None
 1.41A 2q7kA-4k3zA:
undetectable		 2q7kA-4k3zA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 LEU A 293
GLN A 289
MET A  83
VAL A  79
LEU A 269
 None
 0.91A 2q7kA-4lc9A:
undetectable		 2q7kA-4lc9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 LEU A 296
LEU A 293
GLN A 289
VAL A  79
LEU A 269
 None
 1.11A 2q7kA-4lc9A:
undetectable		 2q7kA-4lc9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 283
LEU A 286
MET A 321
ARG A 331
MET A 358
 None
 0.60A 2q7kA-4n1yA:
29.2		 2q7kA-4n1yA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzp ARGININOSUCCINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00764
(Arginosuc_synth) 		5 LEU A 250
ASN A 251
LEU A 253
VAL A 354
THR A 280
 None
 1.28A 2q7kA-4nzpA:
undetectable		 2q7kA-4nzpA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 564
LEU A 566
GLN A 570
MET A 601
ARG A 611
LEU A 732
 MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 4.2A)
 0.78A 2q7kA-4p6wA:
33.2		 2q7kA-4p6wA:
50.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
ARG A 611
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
 0.83A 2q7kA-4p6wA:
33.2		 2q7kA-4p6wA:
50.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
LEU A 938
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
 0.70A 2q7kA-4udbA:
33.8		 2q7kA-4udbA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zck GTP-BINDING PROTEIN
TYPA/BIPA

(Escherichia
coli) 		PF00679
(EFG_C) 		5 LEU A 335
VAL A 382
MET A 309
MET A 373
LEU A 380
 None
 1.25A 2q7kA-4zckA:
undetectable		 2q7kA-4zckA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		5 LEU A 341
ASN A 342
GLN A 339
VAL A 174
LEU A 123
 None
 1.33A 2q7kA-4zm6A:
undetectable		 2q7kA-4zm6A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 LEU A 602
ASN A 603
LEU A 605
VAL A 667
MET A 637
 None
 1.39A 2q7kA-5affA:
undetectable		 2q7kA-5affA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		5 LEU A 420
LEU A 421
VAL A 413
MET A 509
LEU A 132
 None
 1.31A 2q7kA-5cdiA:
undetectable		 2q7kA-5cdiA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2

(Homo sapiens) 		PF00616
(RasGAP) 		5 LEU E1103
ASN E1102
LEU E1104
VAL E1079
LEU E 943
 None
 1.36A 2q7kA-5cjpE:
undetectable		 2q7kA-5cjpE:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctm BETA-LACTAMASE

(Bacillus
pumilus) 		PF00905
(Transpeptidase) 		5 LEU A 109
MET A 157
MET A 146
THR A 114
MET A 166
 None
None
KCX  A 104 ( 4.6A)
None
None
 1.13A 2q7kA-5ctmA:
undetectable		 2q7kA-5ctmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 LEU A 271
LEU A 268
MET A 307
VAL A 100
LEU A  90
 None
 1.31A 2q7kA-5fl7A:
undetectable		 2q7kA-5fl7A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		5 LEU A 131
ASN A 132
LEU A 127
VAL A 146
LEU A 142
 None
 1.06A 2q7kA-5hasA:
undetectable		 2q7kA-5hasA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8n EXODEOXYRIBONUCLEASE
III

(Methanosarcina
mazei) 		PF03372
(Exo_endo_phos) 		5 LEU A 108
ASN A 110
LEU A 109
VAL A 227
LEU A 254
 None
 1.31A 2q7kA-5j8nA:
undetectable		 2q7kA-5j8nA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh5 POLYCOMB GROUP RING
FINGER PROTEIN 1

(Homo sapiens) 		PF16207
(RAWUL) 		5 LEU C 248
LEU C 169
MET C 231
VAL C 200
LEU C 227
 None
 1.38A 2q7kA-5jh5C:
undetectable		 2q7kA-5jh5C:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 LEU A 309
LEU A 313
MET A 218
LEU A 269
THR A 265
 None
None
None
1PE  A 604 ( 4.3A)
1PE  A 604 (-3.5A)
 1.25A 2q7kA-5jlcA:
2.6		 2q7kA-5jlcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 700
ASN A 699
VAL A 767
ARG A 780
LEU A 692
 None
 1.28A 2q7kA-5lstA:
undetectable		 2q7kA-5lstA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PUTATIVE PRE-MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		PF08084
(PROCT) 		5 LEU B2101
LEU B2150
VAL B2190
LEU B2084
MET B2120
 None
 1.19A 2q7kA-5m59B:
undetectable		 2q7kA-5m59B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
MET A 845
LEU A 938
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
 0.64A 2q7kA-5mwpA:
37.3		 2q7kA-5mwpA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlm INDOXYL
UDP-GLUCOSYLTRANSFER
ASE

(Persicaria
tinctoria) 		no annotation 5 LEU A 359
GLN A 355
VAL A 278
MET A 433
LEU A 276
 None
 1.36A 2q7kA-5nlmA:
undetectable		 2q7kA-5nlmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 128
ASN A 132
MET A 271
VAL A 121
LEU A 295
 None
 1.22A 2q7kA-5oasA:
undetectable		 2q7kA-5oasA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 5 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.42A 2q7kA-5ubmA:
undetectable		 2q7kA-5ubmA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 559
ASN A 560
GLN A 566
MET A 597
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
 0.86A 2q7kA-5uc1A:
23.1		 2q7kA-5uc1A:
48.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
ARG A 607
MET A 635
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 1.14A 2q7kA-5uc1A:
23.1		 2q7kA-5uc1A:
48.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLN A  39
MET A  70
ARG A  80
LEU A 201
 1TA  A 301 (-3.0A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.8A)
 0.70A 2q7kA-5ufsA:
35.1		 2q7kA-5ufsA:
53.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
ASN A  33
LEU A  35
GLN A  39
ARG A  80
MET A 108
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
 1.05A 2q7kA-5ufsA:
35.1		 2q7kA-5ufsA:
53.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
 0.75A 2q7kA-5ufsA:
35.1		 2q7kA-5ufsA:
53.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2

(Arabidopsis
thaliana) 		no annotation 5 LEU A  21
ASN A  22
LEU A  24
VAL A  42
LEU A  65
 None
 1.32A 2q7kA-5vjwA:
undetectable		 2q7kA-5vjwA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrj PROTEIN-TYROSINE
SULFOTRANSFERASE 1

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		5 LEU A  89
MET A 182
VAL A 237
MET A 235
LEU A 242
 None
 1.43A 2q7kA-5wrjA:
undetectable		 2q7kA-5wrjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x33 LTB4
RECEPTOR,LYSOZYME,LT
B4 RECEPTOR

(Cavia
porcellus;
Escherichia
virus T4) 		no annotation 5 LEU A  70
ASN A  38
LEU A  35
VAL A  29
LEU A 275
 None
 1.32A 2q7kA-5x33A:
undetectable		 2q7kA-5x33A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 5 LEU A 106
ASN A 107
LEU A 130
LEU A  80
THR A  81
 None
SO4  A 414 (-3.5A)
None
None
SO4  A 414 ( 3.9A)
 1.26A 2q7kA-5xnpA:
undetectable		 2q7kA-5xnpA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6geb DOTB

(Legionella
pneumophila) 		no annotation 5 LEU A  65
ASN A  62
LEU A  60
MET A  21
THR A  78
 None
 1.43A 2q7kA-6gebA:
undetectable		 2q7kA-6gebA:
14.40