SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q7J_A_TESA203_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 700
LEU A 707
GLN A 711
MET A 749
ARG A 752
 None
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
 1.06A 2q7jA-2ax9A:
41.0		 2q7jA-2ax9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 701
ASN A 705
LEU A 707
GLN A 711
MET A 742
MET A 745
MET A 749
ARG A 752
MET A 780
THR A 877
MET A 895
 None
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-3.0A)
None
 0.63A 2q7jA-2ax9A:
41.0		 2q7jA-2ax9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 701
ASN A 705
TRP A 741
MET A 742
MET A 780
THR A 877
MET A 895
 None
BHM  A   1 (-3.6A)
None
BHM  A   1 ( 4.0A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-3.0A)
None
 1.05A 2q7jA-2ax9A:
41.0		 2q7jA-2ax9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 265
LEU A 271
TRP A 305
MET A 306
ARG A 316
 None
OHT  A 500 ( 4.4A)
None
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
 0.83A 2q7jA-2gpvA:
26.0		 2q7jA-2gpvA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  73
LEU A  47
GLN A 461
MET A  37
THR A  21
 None
 1.30A 2q7jA-2panA:
undetectable		 2q7jA-2panA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  29
ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
MET A  73
ARG A  80
MET A 108
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
 0.48A 2q7jA-2q3yA:
37.8		 2q7jA-2q3yA:
59.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 719
LEU A 721
GLN A 725
MET A 756
MET A 759
ARG A 766
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
 0.74A 2q7jA-3kbaA:
35.4		 2q7jA-3kbaA:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 714
LEU A 721
GLN A 725
MET A 759
ARG A 766
 None
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
 1.08A 2q7jA-3kbaA:
35.4		 2q7jA-3kbaA:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 715
ASN A 719
LEU A 721
MET A 756
MET A 759
ARG A 766
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
 0.63A 2q7jA-3kbaA:
35.4		 2q7jA-3kbaA:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 715
ASN A 719
LEU A 721
MET A 756
MET A 909
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
None
 1.10A 2q7jA-3kbaA:
35.4		 2q7jA-3kbaA:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 715
ASN A 719
TRP A 755
MET A 756
MET A 909
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
None
 1.38A 2q7jA-3kbaA:
35.4		 2q7jA-3kbaA:
53.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obv PROTEIN DIAPHANOUS
HOMOLOG 1

(Mus musculus) 		PF02181
(FH2)
PF06345
(Drf_DAD) 		5 LEU E 869
ASN E 865
LEU E 862
MET E 910
MET E 873
 None
 1.34A 2q7jA-3obvE:
undetectable		 2q7jA-3obvE:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		9 LEU A  29
ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
MET A  73
ARG A  80
MET A 108
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
 0.67A 2q7jA-3ry9A:
36.9		 2q7jA-3ry9A:
53.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 280
LEU A 286
TRP A 320
MET A 321
ARG A 331
MET A 358
 None
 0.80A 2q7jA-4n1yA:
28.9		 2q7jA-4n1yA:
28.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 564
LEU A 566
GLN A 570
TRP A 600
MET A 601
MET A 604
ARG A 611
 MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
 0.84A 2q7jA-4p6wA:
33.5		 2q7jA-4p6wA:
49.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 766
ASN A 770
LEU A 772
GLN A 776
TRP A 806
MET A 807
ARG A 817
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
 0.73A 2q7jA-4udbA:
34.0		 2q7jA-4udbA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA

(Mus musculus) 		PF00989
(PAS)
PF08447
(PAS_3) 		5 LEU B 192
MET B 109
MET B 120
THR B 136
MET B 144
 None
 1.30A 2q7jA-4zprB:
undetectable		 2q7jA-4zprB:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 LEU A 766
ASN A 770
LEU A 772
GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 845
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
 0.67A 2q7jA-5mwpA:
37.4		 2q7jA-5mwpA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 ASN A 560
LEU A 562
GLN A 566
ARG A 607
MET A 635
 486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 1.00A 2q7jA-5uc1A:
23.2		 2q7jA-5uc1A:
48.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 ASN A 560
LEU A 562
GLN A 566
MET A 597
MET A 600
ARG A 607
 486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.77A 2q7jA-5uc1A:
23.2		 2q7jA-5uc1A:
48.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 GLN A 566
TRP A 596
MET A 597
MET A 600
ARG A 607
 486  A 801 (-2.8A)
None
CPS  A 803 ( 3.9A)
None
486  A 801 (-3.5A)
 0.69A 2q7jA-5uc1A:
23.2		 2q7jA-5uc1A:
48.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
LEU A  35
GLN A  39
ARG A  80
MET A 108
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
 1.17A 2q7jA-5ufsA:
35.6		 2q7jA-5ufsA:
53.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
MET A  73
ARG A  80
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 (-3.5A)
 0.85A 2q7jA-5ufsA:
35.6		 2q7jA-5ufsA:
53.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  28
LEU A  35
GLN A  39
ARG A  80
MET A 108
 None
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
 1.47A 2q7jA-5ufsA:
35.6		 2q7jA-5ufsA:
53.88