SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q72_A_IXXA801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3u TATA-BINDING PROTEIN

(Pyrococcus
woesei) 		PF00352
(TBP) 		5 LEU A 150
VAL A 141
ILE A 156
ALA A 170
LEU A   9
 None
 1.18A 2q72A-1d3uA:
undetectable		 2q72A-1d3uA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		5 LEU A 193
ARG A 126
VAL A 124
ALA A 120
LEU A 117
 None
 1.21A 2q72A-1f5aA:
0.0		 2q72A-1f5aA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g2p ADENINE
PHOSPHORIBOSYLTRANSF
ERASE 1

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 LEU A 152
GLN A 147
ILE A 127
ALA A 140
LEU A  66
 None
 1.20A 2q72A-1g2pA:
undetectable		 2q72A-1g2pA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		5 LEU A  25
LEU A   5
ILE A 104
ALA A  31
ASP A 120
 None
 1.17A 2q72A-1gk2A:
0.1		 2q72A-1gk2A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 267
ARG A 274
ILE A 215
LEU A 173
ASP A 171
 None
 1.19A 2q72A-1h4lA:
0.0		 2q72A-1h4lA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae) 		PF13649
(Methyltransf_25) 		5 LEU A 130
LEU A 161
ILE A 149
ALA A 239
LEU A 153
 None
 1.21A 2q72A-1im8A:
undetectable		 2q72A-1im8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkt PROTEIN YFIR

(Bacillus
subtilis) 		PF00440
(TetR_N) 		5 LEU A  75
LEU A 141
ILE A  88
PHE A 134
LEU A 196
 None
 1.21A 2q72A-1rktA:
0.5		 2q72A-1rktA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rty YVQK PROTEIN

(Bacillus
subtilis) 		PF01923
(Cob_adeno_trans) 		5 LEU A  67
VAL A  90
ILE A  33
LEU A  74
ASP A  73
 None
 0.99A 2q72A-1rtyA:
undetectable		 2q72A-1rtyA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sw6 REGULATORY PROTEIN
SWI6

(Saccharomyces
cerevisiae) 		PF00023
(Ank)
PF13857
(Ank_5) 		5 LEU A 230
LEU A 453
ILE A 382
LEU A 345
ASP A 220
 None
 1.22A 2q72A-1sw6A:
0.0		 2q72A-1sw6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 LEU A 225
LEU A 228
ARG A 226
ILE A 203
ASP A 262
 None
 1.00A 2q72A-1szsA:
undetectable		 2q72A-1szsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 104
VAL A 261
ILE A 200
ALA A 110
LEU A 166
 None
 1.09A 2q72A-1u08A:
0.0		 2q72A-1u08A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		5 ARG A 239
VAL A 232
ILE A 246
ALA A 230
ASP A 209
 None
 1.18A 2q72A-1w25A:
0.0		 2q72A-1w25A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		5 LEU A  21
LEU A  15
ILE A 155
LEU A 119
ASP A 123
 None
 1.19A 2q72A-1yd9A:
undetectable		 2q72A-1yd9A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu GIANT HEMOGLOBINS B
CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		5 LEU B  89
LEU B  85
ILE B 138
ALA B  77
LEU B  72
 None
None
None
None
HEM  B 160 (-4.3A)
 1.10A 2q72A-1yhuB:
undetectable		 2q72A-1yhuB:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389

(Mycobacterium
tuberculosis) 		PF13523
(Acetyltransf_8) 		5 LEU A  94
LEU A  45
ARG A  46
LEU A  56
ASP A  52
 None
 1.18A 2q72A-1yk3A:
undetectable		 2q72A-1yk3A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae6 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		5 ARG A   8
ILE A  52
ALA A  55
LEU A  18
ASP A  14
 None
 1.06A 2q72A-2ae6A:
undetectable		 2q72A-2ae6A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae6 ACETYLTRANSFERASE,
GNAT FAMILY

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		5 LEU A   9
ARG A   8
ALA A  55
LEU A  18
ASP A  14
 None
 1.09A 2q72A-2ae6A:
undetectable		 2q72A-2ae6A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		5 LEU A 893
LEU A 941
ILE A 945
ALA A 902
LEU A 930
 None
 1.22A 2q72A-2c3oA:
undetectable		 2q72A-2c3oA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		5 LEU A 360
LEU A 363
VAL A 367
ILE A 432
LEU A 397
 None
 1.19A 2q72A-2canA:
undetectable		 2q72A-2canA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f31 DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 LEU A 147
ARG A 148
ILE A 185
LEU A 189
ASP A 201
 None
 1.12A 2q72A-2f31A:
undetectable		 2q72A-2f31A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 177
LEU A 191
ILE A 179
PHE A 143
LEU A 159
 None
 1.17A 2q72A-2ft3A:
undetectable		 2q72A-2ft3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
carnosus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		5 LEU A 407
LEU A 375
ILE A 389
ALA A 377
LEU A 387
 None
 1.21A 2q72A-2hroA:
undetectable		 2q72A-2hroA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odm UPF0358 PROTEIN
MW0995

(Staphylococcus
aureus) 		PF07408
(DUF1507) 		5 LEU A  12
ILE A  73
ALA A  59
LEU A  52
ASP A  18
 None
 1.21A 2q72A-2odmA:
undetectable		 2q72A-2odmA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Bacillus
anthracis) 		PF02540
(NAD_synthase) 		5 LEU A  58
LEU A  54
ARG A  57
ILE A  23
ALA A 199
 None
 1.21A 2q72A-2pz8A:
undetectable		 2q72A-2pz8A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 154
ILE A 245
ALA A 251
LEU A 228
ASP A 285
 None
 1.19A 2q72A-2x4fA:
undetectable		 2q72A-2x4fA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		5 LEU A 190
PHE A 280
ALA A 197
ASP A 291
ASP A 288
 None
 1.17A 2q72A-2zq5A:
undetectable		 2q72A-2zq5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 LEU A1302
VAL A1309
GLN A1311
ILE A1590
LEU A1154
 None
None
None
None
SAM  A   1 (-4.7A)
 1.17A 2q72A-3av6A:
undetectable		 2q72A-3av6A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		5 LEU A 193
ILE A 242
ALA A 149
LEU A 272
ASP A 269
 None
 1.16A 2q72A-3e03A:
undetectable		 2q72A-3e03A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		5 LEU A 220
ILE A  43
ALA A 124
LEU A  65
ASP A  57
 None
None
SAH  A 300 ( 4.2A)
None
SAH  A 300 ( 4.7A)
 1.19A 2q72A-3e8sA:
undetectable		 2q72A-3e8sA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2e SIRV COAT PROTEIN

(Rudivirus) 		PF12193
(Sulf_coat_C) 		5 VAL A  55
GLN A  58
ILE A 100
ALA A  84
LEU A  96
 None
 1.14A 2q72A-3f2eA:
undetectable		 2q72A-3f2eA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8m GNTR-FAMILY PROTEIN
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF00392
(GntR)
PF07702
(UTRA) 		5 LEU A 127
ARG A 154
ALA A 102
LEU A 106
ASP A 105
 None
 1.22A 2q72A-3f8mA:
undetectable		 2q72A-3f8mA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3geh TRNA MODIFICATION
GTPASE MNME

(Nostoc sp. PCC
7120) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 LEU A 165
LEU A 435
ILE A 205
ALA A 400
LEU A 209
 None
 1.21A 2q72A-3gehA:
undetectable		 2q72A-3gehA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Shewanella
denitrificans) 		PF01380
(SIS) 		5 LEU A 299
LEU A 185
ILE A 296
ALA A 187
ASP A 291
 None
 1.18A 2q72A-3hbaA:
undetectable		 2q72A-3hbaA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhc INTERLEUKIN-28B

(Homo sapiens) 		PF15177
(IL28A) 		5 LEU A  72
LEU A  86
GLN A  88
ALA A  19
LEU A 149
 None
None
None
IOD  A 164 ( 4.0A)
None
 1.18A 2q72A-3hhcA:
2.8		 2q72A-3hhcA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 404
ARG A 405
VAL A 282
ILE A 246
ALA A 280
 None
 1.17A 2q72A-3hhdA:
undetectable		 2q72A-3hhdA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		5 LEU A 393
LEU A 392
VAL A 362
ALA A 323
LEU A  56
 None
 1.11A 2q72A-3ihgA:
1.2		 2q72A-3ihgA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 LEU A 223
LEU A 226
ARG A 227
VAL A 229
ASP A 262
 None
 1.19A 2q72A-3k28A:
undetectable		 2q72A-3k28A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Bacillus cereus) 		PF01923
(Cob_adeno_trans) 		5 LEU A  66
VAL A  89
ILE A  33
LEU A  73
ASP A  72
 None
 1.05A 2q72A-3ke5A:
undetectable		 2q72A-3ke5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lti DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Escherichia
coli) 		PF04561
(RNA_pol_Rpb2_2) 		5 LEU A 210
ILE A 425
PHE A 385
ALA A 206
LEU A 184
 None
MLY  A 422 ( 4.1A)
None
None
None
 1.11A 2q72A-3ltiA:
undetectable		 2q72A-3ltiA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lti DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Escherichia
coli) 		PF04561
(RNA_pol_Rpb2_2) 		5 LEU A 213
LEU A 210
ILE A 425
ALA A 206
LEU A 184
 MLY  A 422 ( 4.1A)
None
MLY  A 422 ( 4.1A)
None
None
 1.08A 2q72A-3ltiA:
undetectable		 2q72A-3ltiA:
18.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 LEU A  25
LEU A  29
ARG A  30
VAL A  33
ALA A 319
 LEU  A 601 (-4.9A)
None
None
None
None
 1.03A 2q72A-3mpnA:
67.9		 2q72A-3mpnA:
99.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		10 LEU A  25
LEU A  29
VAL A  33
GLN A  34
ILE A 111
PHE A 253
ALA A 319
LEU A 400
ASP A 401
ASP A 404
 LEU  A 601 (-4.9A)
None
None
None
None
LEU  A 601 (-4.2A)
None
None
None
None
 0.50A 2q72A-3mpnA:
67.9		 2q72A-3mpnA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT
PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans;
Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU B  74
LEU B  73
GLN A 643
ILE B 114
ALA B 269
 None
 1.19A 2q72A-3n6rB:
undetectable		 2q72A-3n6rB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A  15
LEU A 134
ARG A 133
LEU A 129
ASP A  18
 None
 0.91A 2q72A-3nwrA:
undetectable		 2q72A-3nwrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		5 LEU A 205
LEU A 208
ARG A 206
ILE A 183
ASP A 242
 None
 1.02A 2q72A-3nx3A:
undetectable		 2q72A-3nx3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU B 669
LEU B 673
VAL B 557
ILE B 524
ALA B 554
 None
 1.16A 2q72A-3pcoB:
undetectable		 2q72A-3pcoB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		5 LEU A1299
VAL A1306
GLN A1308
ILE A1588
LEU A1151
 None
None
None
None
SAH  A1601 (-3.6A)
 1.13A 2q72A-3ptaA:
undetectable		 2q72A-3ptaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pty ARABINOSYLTRANSFERAS
E C

(Mycobacterium
tuberculosis) 		PF14896
(Arabino_trans_C) 		5 LEU A 744
VAL A 736
LEU A1049
ASP A1052
ASP A1051
 None
AFO  A   1 ( 4.9A)
None
None
AFO  A   1 (-4.7A)
 1.17A 2q72A-3ptyA:
undetectable		 2q72A-3ptyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 136
ARG A 133
ILE A 149
ALA A 159
ASP A 153
 None
 1.18A 2q72A-3pwzA:
undetectable		 2q72A-3pwzA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q62 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Yersinia pestis) 		PF07977
(FabA) 		5 ARG A   5
VAL A   2
ILE A  40
LEU A  13
ASP A  12
 None
 1.10A 2q72A-3q62A:
undetectable		 2q72A-3q62A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip CASPASE

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		5 LEU A 111
GLN A 108
ILE A 114
ALA A 104
LEU A  72
 None
 0.86A 2q72A-3sipA:
undetectable		 2q72A-3sipA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		5 VAL A 394
ILE A  15
PHE A 415
ALA A 243
LEU A 254
 None
 1.17A 2q72A-3tr1A:
undetectable		 2q72A-3tr1A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 146
ARG A 273
ILE A  91
ASP A 434
ASP A 463
 None
 0.96A 2q72A-3v9eA:
undetectable		 2q72A-3v9eA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 365
GLN A 355
ILE A 241
LEU A 499
ASP A 498
 None
 1.20A 2q72A-3vskA:
undetectable		 2q72A-3vskA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		5 LEU B  88
LEU B  84
ILE B 137
ALA B  76
LEU B  71
 None
None
None
None
HEM  B 201 (-4.4A)
 1.07A 2q72A-3wcuB:
undetectable		 2q72A-3wcuB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 LEU A 275
LEU A 279
ILE A 271
ALA A 310
LEU A 303
 None
 1.18A 2q72A-3wv4A:
undetectable		 2q72A-3wv4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 LEU A 275
LEU A 279
ILE A 271
ALA A 310
LEU A 303
 None
 1.22A 2q72A-3wvnA:
undetectable		 2q72A-3wvnA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 LEU A 257
ILE A 162
PHE A 144
ALA A 159
LEU A 214
 None
 1.18A 2q72A-3zzuA:
undetectable		 2q72A-3zzuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1

(Methanocaldococcus
jannaschii) 		PF00999
(Na_H_Exchanger) 		5 LEU A  66
LEU A  70
ILE A 165
ALA A 250
ASP A 234
 None
 1.22A 2q72A-4czbA:
undetectable		 2q72A-4czbA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 LEU A   8
LEU A  86
ARG A 128
VAL A 126
ALA A 123
 None
 1.16A 2q72A-4e3zA:
undetectable		 2q72A-4e3zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		5 LEU A 223
LEU A 226
ARG A 224
ILE A 201
ASP A 259
 None
 1.01A 2q72A-4e77A:
undetectable		 2q72A-4e77A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 LEU A 131
LEU A 162
ILE A 150
ALA A 240
LEU A 154
 None
 1.12A 2q72A-4gekA:
undetectable		 2q72A-4gekA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 LEU A 131
LEU A 162
ILE A 150
ALA A 240
LEU A 154
 None
 1.14A 2q72A-4iwnA:
undetectable		 2q72A-4iwnA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		5 ARG A  65
VAL A  30
ILE A  77
ALA A  73
ASP A  90
 None
 1.13A 2q72A-4jeuA:
2.4		 2q72A-4jeuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 137
LEU A 113
ARG A 138
ALA A  92
ASP A 140
 None
 1.20A 2q72A-4li2A:
undetectable		 2q72A-4li2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovy HALOACID
DEHALOGENASE DOMAIN
PROTEIN HYDROLASE

(Planctopirus
limnophila) 		PF12710
(HAD) 		5 LEU A 278
VAL A 280
ILE A  39
PHE A  64
LEU A  27
 None
 1.18A 2q72A-4ovyA:
undetectable		 2q72A-4ovyA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		5 LEU A 483
ILE A 362
ALA A 324
LEU A 341
ASP A 304
 None
 1.19A 2q72A-4pspA:
undetectable		 2q72A-4pspA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 LEU A 288
LEU A 284
ILE A 328
ALA A 271
LEU A 305
 None
 1.10A 2q72A-4q3rA:
undetectable		 2q72A-4q3rA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		5 LEU A  27
LEU A  30
VAL A  34
GLN A  35
ASP A  69
 None
 1.16A 2q72A-4qgkA:
1.2		 2q72A-4qgkA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  48
GLN A  71
ILE A  64
ALA A  76
LEU A  86
 None
 1.20A 2q72A-4qxeA:
undetectable		 2q72A-4qxeA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Aliivibrio
fischeri) 		PF00092
(VWA) 		5 LEU A  63
LEU A  20
VAL A  22
ILE A  55
ASP A  90
 None
 1.02A 2q72A-4rckA:
undetectable		 2q72A-4rckA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 LEU A 114
ARG A 117
GLN A 116
ILE A  60
ASP A  69
 None
 1.18A 2q72A-4u1rA:
undetectable		 2q72A-4u1rA:
23.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		6 LEU A  29
ARG A  34
ILE A 111
PHE A 230
ASP A 382
ASP A 385
 None
None
None
TRP  A 601 (-4.4A)
None
None
 0.85A 2q72A-4us4A:
40.3		 2q72A-4us4A:
32.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x04 SOLUTE BINDING
PROTEIN

(Citrobacter
koseri) 		PF03480
(DctP) 		5 LEU A  53
VAL A  65
ILE A 260
ALA A  32
LEU A 145
 None
 1.22A 2q72A-4x04A:
undetectable		 2q72A-4x04A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 LEU A 545
ILE A 520
PHE A 500
ALA A 684
LEU A 504
 None
 1.17A 2q72A-4yzwA:
undetectable		 2q72A-4yzwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afe ENDOGLUCANASE CEL5A

([Eubacterium]
cellulosolvens) 		no annotation 5 LEU A 641
ILE A 686
PHE A 628
ALA A 652
LEU A 683
 None
 1.13A 2q72A-5afeA:
undetectable		 2q72A-5afeA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz0 REPLICASE
POLYPROTEIN 1AB

(Avian
coronavirus) 		PF08715
(Viral_protease) 		5 LEU A 230
ALA A 292
LEU A 204
ASP A 247
ASP A 249
 None
 1.16A 2q72A-5bz0A:
undetectable		 2q72A-5bz0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvc SERINE RACEMASE

(Zea mays) 		PF00291
(PALP) 		5 LEU A 285
VAL A 289
ILE A  45
ALA A 294
LEU A 301
 None
 0.87A 2q72A-5cvcA:
undetectable		 2q72A-5cvcA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cws NUCLEOPORIN NIC96
NUCLEOPORIN NSP1
NUCLEOPORIN NUP57

(Chaetomium
thermophilum) 		PF05064
(Nsp1_C)
PF13874
(Nup54)
no annotation 		5 LEU E 294
LEU E 297
VAL E 301
ALA C 637
LEU F 180
 None
 1.13A 2q72A-5cwsE:
undetectable		 2q72A-5cwsE:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 336
ILE A 246
PHE A  24
ALA A 343
LEU A 122
 None
 1.07A 2q72A-5eytA:
undetectable		 2q72A-5eytA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		5 LEU A 268
VAL A 441
GLN A 262
ILE A 197
ALA A 464
 None
 1.19A 2q72A-5glgA:
undetectable		 2q72A-5glgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		5 LEU A 372
LEU A 376
ARG A 373
ILE A 306
ASP A 277
 None
 1.16A 2q72A-5h5mA:
undetectable		 2q72A-5h5mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		5 LEU A 265
VAL A 202
ILE A  35
ALA A 258
LEU A  11
 None
 1.21A 2q72A-5ihvA:
undetectable		 2q72A-5ihvA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		5 LEU A 297
ARG A 296
ILE A 337
LEU A 287
ASP A 285
 None
None
None
EDO  A 509 (-4.1A)
None
 0.99A 2q72A-5jijA:
undetectable		 2q72A-5jijA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE

(Pseudomonas
mendocina) 		PF11927
(DUF3445) 		5 LEU A 182
LEU A  83
ARG A 183
LEU A  75
ASP A  78
 None
 1.21A 2q72A-5ltiA:
undetectable		 2q72A-5ltiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mh5 D-2-HYDROXYACID
DEHYDROGENASE

(Haloferax
mediterranei) 		no annotation 5 LEU A 239
LEU A 235
VAL A 231
ILE A 244
ALA A 208
 None
 1.22A 2q72A-5mh5A:
undetectable		 2q72A-5mh5A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms7 LEGIONELLA
PNEUMOPHILA EFFECTOR
PROTEIN RAVZ

(Legionella
pneumophila) 		no annotation 5 LEU A  71
LEU A  74
ILE A 301
ALA A  81
LEU A 293
 None
 0.97A 2q72A-5ms7A:
undetectable		 2q72A-5ms7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 5 LEU A 109
VAL A 167
GLN A 147
ILE A  88
ALA A 217
 None
 1.13A 2q72A-5muxA:
undetectable		 2q72A-5muxA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 LEU A 106
VAL A 108
ILE A 860
ALA A 527
LEU A  55
 None
 1.03A 2q72A-5nd1A:
undetectable		 2q72A-5nd1A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 LEU B 107
LEU B 105
ALA B 172
LEU B 183
ASP B 179
 None
 1.15A 2q72A-5of4B:
1.5		 2q72A-5of4B:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L23,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L47,
MITOCHONDRIAL

(Homo sapiens) 		PF00276
(Ribosomal_L23)
PF06984
(MRP-L47) 		5 LEU Y 106
ARG U  21
VAL U  19
ALA U   2
ASP Y 143
 None
 1.20A 2q72A-5oomY:
3.8		 2q72A-5oomY:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 205
GLN A 211
ILE A 146
PHE A 244
LEU A 158
 None
 0.95A 2q72A-5opjA:
0.3		 2q72A-5opjA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 2
CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 5 LEU C 529
LEU C 528
ILE A 631
ALA A 624
ASP A 584
 None
 1.04A 2q72A-5oqrC:
undetectable		 2q72A-5oqrC:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 LEU A 898
VAL A 972
ILE A 920
ALA A 977
ASP A 804
 None
 1.18A 2q72A-5t8vA:
undetectable		 2q72A-5t8vA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 5 LEU B  90
LEU B  87
ILE B  47
LEU B 316
ASP B 315
 None
 1.11A 2q72A-5thzB:
undetectable		 2q72A-5thzB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufb TN4-22

(Petromyzon
marinus) 		no annotation 5 LEU A 150
LEU A 153
ILE A 147
ALA A 180
LEU A 143
 None
 1.13A 2q72A-5ufbA:
undetectable		 2q72A-5ufbA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5f TAIL TUBE PROTEIN
GP19

(Enterobacteria
phage T4 sensu
lato) 		PF06841
(Phage_T4_gp19) 		5 LEU A 132
LEU A 157
VAL A 137
GLN A  89
ILE A  25
 None
 1.18A 2q72A-5w5fA:
undetectable		 2q72A-5w5fA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 LEU A 259
LEU A 272
ILE A 257
PHE A 304
LEU A 286
 None
 1.19A 2q72A-5xdrA:
undetectable		 2q72A-5xdrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans) 		no annotation 5 LEU A 140
ARG A 141
GLN A 229
ALA A 293
ASP A  46
 None
 1.21A 2q72A-6d3uA:
undetectable		 2q72A-6d3uA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z UPF0434 FAMILY
PROTEIN

(Haloferax
volcanii) 		no annotation 5 LEU C  20
LEU C  35
ARG C  34
ILE C  30
ASP C  23
 GOL  C 101 (-4.4A)
GOL  C 101 (-4.8A)
None
None
None
 1.15A 2q72A-6f5zC:
undetectable		 2q72A-6f5zC:
8.84