SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q6O_B_SAMB500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP H 197
VAL H 198
PRO H 194
THR H 137
 None
 1.31A 2q6oB-1adqH:
undetectable		 2q6oB-1adqH:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1b PROTEIN (IRON
DEPENDENT REGULATOR)

(Mycobacterium
tuberculosis) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		4 ASP A  88
VAL A  87
PRO A 123
THR A 125
 None
 1.33A 2q6oB-1b1bA:
undetectable		 2q6oB-1b1bA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ftg APOFLAVODOXIN

(Nostoc sp. PCC
7119) 		PF00258
(Flavodoxin_1) 		4 ASP A  35
VAL A  36
THR A  15
TRP A  66
 None
None
SO4  A 700 (-3.6A)
None
 1.30A 2q6oB-1ftgA:
2.7		 2q6oB-1ftgA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 VAL B 858
PHE B 884
PRO B 849
THR B 850
 None
 1.34A 2q6oB-1gl9B:
undetectable		 2q6oB-1gl9B:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE

(Pyrococcus
furiosus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ASP A 139
PRO A 141
THR A 174
TRP A 355
 None
 1.26A 2q6oB-1gtmA:
undetectable		 2q6oB-1gtmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igy IGG1 INTACT ANTIBODY
MAB61.1.3

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP B 262
VAL B 268
PRO B 260
THR B 401
 GAL  B 481 ( 4.6A)
None
None
None
 1.44A 2q6oB-1igyB:
undetectable		 2q6oB-1igyB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 ASP A  96
VAL A 127
PRO A 121
THR A 118
 None
None
None
TRS  A2922 ( 4.2A)
 1.32A 2q6oB-1kq3A:
undetectable		 2q6oB-1kq3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lry PEPTIDE DEFORMYLASE

(Pseudomonas
aeruginosa) 		PF01327
(Pep_deformylase) 		4 VAL A 122
PHE A  77
PRO A  79
THR A  81
 None
 1.40A 2q6oB-1lryA:
undetectable		 2q6oB-1lryA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 VAL A 303
PHE A 378
THR A 380
TRP A 397
 None
 1.46A 2q6oB-1lxtA:
undetectable		 2q6oB-1lxtA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		4 ASP A 239
VAL A 242
PRO A 258
THR A 255
 None
 1.33A 2q6oB-1wg8A:
undetectable		 2q6oB-1wg8A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ASP A 588
VAL A 586
THR A 337
TRP A 203
 NA  A7501 (-2.9A)
None
PEG  A9001 (-3.6A)
None
 1.31A 2q6oB-1yq2A:
undetectable		 2q6oB-1yq2A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxx 6-PHOSPHOFRUCTOKINAS
E

(Lactobacillus
delbrueckii) 		PF00365
(PFK) 		4 ASP A  56
VAL A  57
PHE A  50
PRO A  51
 None
 1.37A 2q6oB-1zxxA:
3.0		 2q6oB-1zxxA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 ASP A  96
VAL A 127
PHE A 120
PRO A  93
 None
 1.34A 2q6oB-2a7sA:
undetectable		 2q6oB-2a7sA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avf COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 ASP A  79
VAL A  39
PRO A  36
THR A  34
 None
 1.21A 2q6oB-2avfA:
undetectable		 2q6oB-2avfA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		4 VAL A 207
PHE A 145
PRO A 267
THR A 269
 None
 1.36A 2q6oB-2b3bA:
2.1		 2q6oB-2b3bA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ASP A 396
VAL A 398
PRO A 320
TRP A 364
 None
 1.26A 2q6oB-2bv5A:
undetectable		 2q6oB-2bv5A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA

(Human
mastadenovirus
C) 		PF01686
(Adeno_Penton_B) 		4 VAL A 478
PHE A 397
PRO A 398
TRP A 376
 None
 1.30A 2q6oB-2c6sA:
undetectable		 2q6oB-2c6sA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 4 ASP A 247
VAL A 246
PHE A 283
PRO A   6
 None
 1.25A 2q6oB-2f9rA:
undetectable		 2q6oB-2f9rA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 4 ASP H 485
VAL H 487
PHE H 491
PRO H 484
 None
 1.47A 2q6oB-2fhgH:
undetectable		 2q6oB-2fhgH:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		4 ASP A  66
VAL A  75
PRO A  68
THR A  99
 None
 1.15A 2q6oB-2fvmA:
undetectable		 2q6oB-2fvmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsn GU4 NUCLEIC-BINDING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 VAL B  52
PHE B  58
THR B  68
TRP B  33
 None
 1.44A 2q6oB-2hsnB:
undetectable		 2q6oB-2hsnB:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it0 IRON-DEPENDENT
REPRESSOR IDER

(Mycobacterium
tuberculosis) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		4 ASP A  88
VAL A  87
PRO A 123
THR A 125
 None
 1.40A 2q6oB-2it0A:
undetectable		 2q6oB-2it0A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 ASP A 478
VAL A 477
PRO A 509
THR A 492
 None
 1.22A 2q6oB-2nq5A:
undetectable		 2q6oB-2nq5A:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		6 ASP A  11
VAL A  12
PHE A  45
PRO A  73
THR A  75
TRP A 129
 ADN  A 699 (-2.9A)
None
ADN  A 699 (-4.4A)
ADN  A 699 (-4.0A)
ADN  A 699 (-3.4A)
None
 0.22A 2q6oB-2q6kA:
40.2		 2q6oB-2q6kA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		4 VAL A  12
PHE A  45
THR A 128
TRP A 129
 None
ADN  A 699 (-4.4A)
None
None
 1.45A 2q6oB-2q6kA:
40.2		 2q6oB-2q6kA:
99.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ASP G 503
VAL G 529
PRO G 506
THR G 166
 None
 1.14A 2q6oB-2uv8G:
undetectable		 2q6oB-2uv8G:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzw PROBABLE HISTIDINE
KINASE RESPONSE
REGULATOR

(Mycobacterium
tuberculosis) 		PF13185
(GAF_2) 		4 ASP A 183
VAL A  77
PRO A 178
THR A 152
 None
 1.34A 2q6oB-2vzwA:
undetectable		 2q6oB-2vzwA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		4 VAL A  44
PHE A 170
THR A 270
TRP A 281
 None
 1.15A 2q6oB-2weuA:
undetectable		 2q6oB-2weuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		4 ASP A  25
PHE A 107
PRO A  24
THR A 297
 None
 1.45A 2q6oB-2za1A:
undetectable		 2q6oB-2za1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ASP A  55
VAL A  54
PHE A 103
THR A  61
 None
 1.47A 2q6oB-3a8kA:
undetectable		 2q6oB-3a8kA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		4 VAL A  40
PHE A 126
PRO A 127
THR A 120
 None
 1.25A 2q6oB-3al0A:
undetectable		 2q6oB-3al0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqo FBP32

(Morone
saxatilis) 		PF00754
(F5_F8_type_C) 		4 VAL A 127
PRO A  51
THR A  45
TRP A  53
 None
 1.47A 2q6oB-3cqoA:
undetectable		 2q6oB-3cqoA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		4 ASP A 279
VAL A 313
PRO A 306
THR A 428
 None
 1.42A 2q6oB-3djdA:
undetectable		 2q6oB-3djdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 PHE A 125
PRO A 299
THR A 300
TRP A 302
 None
 1.20A 2q6oB-3ec7A:
1.8		 2q6oB-3ec7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 ASP A 783
VAL A 768
PHE A 148
THR A 734
 None
 1.04A 2q6oB-3egwA:
2.7		 2q6oB-3egwA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		4 VAL A 283
PHE A 328
PRO A 296
THR A 297
 None
 1.38A 2q6oB-3f0hA:
undetectable		 2q6oB-3f0hA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 225
PHE A 334
PRO A 222
THR A 313
 None
 1.00A 2q6oB-3g5wA:
undetectable		 2q6oB-3g5wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		4 VAL A 121
PRO A 117
THR A 115
TRP A 101
 None
None
None
FES  A 401 (-4.1A)
 1.16A 2q6oB-3gcfA:
undetectable		 2q6oB-3gcfA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goh ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Shewanella
oneidensis) 		PF08240
(ADH_N) 		4 ASP A  64
VAL A  63
PRO A 126
THR A 129
 None
 0.97A 2q6oB-3gohA:
undetectable		 2q6oB-3gohA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 VAL A  39
PHE A 132
PRO A 133
THR A 126
 None
 1.25A 2q6oB-3h0lA:
undetectable		 2q6oB-3h0lA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Methanocaldococcus
jannaschii) 		PF06026
(Rib_5-P_isom_A) 		4 ASP A 110
VAL A 109
PHE A 207
THR A  28
 None
None
None
CL  A 231 (-4.9A)
 1.12A 2q6oB-3ixqA:
undetectable		 2q6oB-3ixqA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9q SHEATH

(Pseudomonas
aeruginosa) 		PF04984
(Phage_sheath_1)
PF17482
(Phage_sheath_1C) 		4 ASP A 212
PHE A 208
THR A 286
TRP A 218
 None
 1.29A 2q6oB-3j9qA:
3.4		 2q6oB-3j9qA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 PHE A 123
PRO A 124
THR A 163
TRP A 178
 None
 1.47A 2q6oB-3jclA:
undetectable		 2q6oB-3jclA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 VAL A 127
PRO A 124
THR A 163
TRP A 178
 None
 1.44A 2q6oB-3jclA:
undetectable		 2q6oB-3jclA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ASP A 151
PRO A 153
THR A 184
TRP A 362
 None
 1.33A 2q6oB-3k92A:
1.7		 2q6oB-3k92A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kes NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF04096
(Nucleoporin2) 		4 PHE A 573
PRO A 593
THR A 597
TRP A 598
 None
EDO  A   7 ( 4.4A)
None
None
 1.45A 2q6oB-3kesA:
undetectable		 2q6oB-3kesA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw2 PROBABLE R-RNA
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		PF04452
(Methyltrans_RNA) 		4 ASP A 200
VAL A 166
PHE A 201
PRO A 197
 ADN  A 300 (-3.3A)
ADN  A 300 (-4.1A)
None
ADN  A 300 (-4.9A)
 1.08A 2q6oB-3kw2A:
2.9		 2q6oB-3kw2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw2 PROBABLE R-RNA
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		PF04452
(Methyltrans_RNA) 		4 ASP A 200
VAL A 166
PRO A 197
THR A 226
 ADN  A 300 (-3.3A)
ADN  A 300 (-4.1A)
ADN  A 300 (-4.9A)
ADN  A 300 (-4.1A)
 1.41A 2q6oB-3kw2A:
2.9		 2q6oB-3kw2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 ASP A 224
VAL A 362
PRO A 173
THR A 171
 None
 1.27A 2q6oB-3ldoA:
undetectable		 2q6oB-3ldoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 ASP A 205
PHE A 161
THR A 167
TRP A 201
 None
 1.45A 2q6oB-3lg5A:
undetectable		 2q6oB-3lg5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzy MOG

(Mycobacterium
avium) 		PF00994
(MoCF_biosynth) 		4 ASP A  22
VAL A  44
PRO A  26
THR A  29
 None
 1.45A 2q6oB-3pzyA:
5.0		 2q6oB-3pzyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 ASP A 244
VAL A 382
PRO A 193
THR A 191
 None
 1.27A 2q6oB-3qmlA:
undetectable		 2q6oB-3qmlA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnt NIEMANN-PICK C1-LIKE
PROTEIN 1

(Homo sapiens) 		PF16414
(NPC1_N) 		4 ASP A 118
VAL A 121
PRO A 114
THR A 111
 None
 1.44A 2q6oB-3qntA:
undetectable		 2q6oB-3qntA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsq CAPSID POLYPROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		4 ASP A 620
VAL A 619
PHE A 524
THR A 591
 None
 0.99A 2q6oB-3qsqA:
undetectable		 2q6oB-3qsqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0o RIBONUCLEASE T2

(Homo sapiens) 		PF00445
(Ribonuclease_T2) 		4 ASP A  99
VAL A 100
PHE A 104
PRO A 105
 None
 1.41A 2q6oB-3t0oA:
undetectable		 2q6oB-3t0oA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ub9 CHEMORECEPTOR TLPB

(Helicobacter
pylori) 		PF17200
(sCache_2) 		4 ASP A 114
VAL A 116
PHE A 113
THR A 183
 NHY  A 301 (-2.6A)
NHY  A 301 (-3.9A)
None
NHY  A 301 ( 4.3A)
 1.11A 2q6oB-3ub9A:
undetectable		 2q6oB-3ub9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 VAL A 170
PHE A  42
PRO A 144
TRP A 146
 None
 1.42A 2q6oB-3w6qA:
undetectable		 2q6oB-3w6qA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		4 VAL A 601
PRO A 605
THR A 607
TRP A 585
 None
 1.46A 2q6oB-4bq4A:
undetectable		 2q6oB-4bq4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ASP A 233
PHE A 235
PRO A 232
THR A 230
 None
 1.15A 2q6oB-4eo4A:
2.7		 2q6oB-4eo4A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euf PUTATIVE REDUCTASE
CA_C0462

(Clostridium
acetobutylicum) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 ASP A 347
VAL A 346
PRO A 229
THR A 231
 None
 1.09A 2q6oB-4eufA:
undetectable		 2q6oB-4eufA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		no annotation 4 VAL B2150
PHE B2145
PRO B2202
THR B2204
 None
 1.35A 2q6oB-4f6lB:
undetectable		 2q6oB-4f6lB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		4 ASP A 171
VAL A 174
PRO A 167
THR A 165
 None
 1.29A 2q6oB-4fl0A:
undetectable		 2q6oB-4fl0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00202
(Aminotran_3) 		4 ASP A 256
VAL A 258
PHE A 221
THR A 161
 LLP  A 285 ( 3.0A)
LLP  A 285 ( 4.1A)
None
None
 1.26A 2q6oB-4grxA:
undetectable		 2q6oB-4grxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		4 VAL A 269
PHE A 441
PRO A 266
THR A 298
 None
 1.21A 2q6oB-4i8qA:
undetectable		 2q6oB-4i8qA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 ASP A  57
VAL A  56
PRO A  76
THR A  74
 None
EDO  A 405 ( 4.4A)
None
None
 1.42A 2q6oB-4idaA:
undetectable		 2q6oB-4idaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 VAL A 183
PRO A 178
THR A 520
TRP A 519
 None
 1.45A 2q6oB-4idmA:
2.1		 2q6oB-4idmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		4 VAL A 437
PHE A 435
PRO A 441
THR A 444
 None
 1.46A 2q6oB-4il1A:
undetectable		 2q6oB-4il1A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 4 ASP A 546
VAL A 525
THR A 477
TRP A 542
 None
 1.47A 2q6oB-4lgnA:
undetectable		 2q6oB-4lgnA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 VAL A  95
PHE A 148
PRO A 240
THR A 111
 None
 1.43A 2q6oB-4mijA:
undetectable		 2q6oB-4mijA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 VAL B  68
PHE B  65
PRO B 139
THR B 133
 None
 1.26A 2q6oB-4nfuB:
undetectable		 2q6oB-4nfuB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 VAL A 442
PRO A 103
THR A 105
TRP A 157
 None
 1.39A 2q6oB-4o6rA:
2.3		 2q6oB-4o6rA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF13614
(AAA_31) 		4 VAL A 203
PHE A 268
PRO A 190
THR A 191
 None
 1.31A 2q6oB-4pfsA:
undetectable		 2q6oB-4pfsA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF13614
(AAA_31) 		4 VAL A 207
PHE A 268
PRO A 190
THR A 191
 None
 1.45A 2q6oB-4pfsA:
undetectable		 2q6oB-4pfsA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII

(Loxosceles
intermedia) 		no annotation 4 ASP A 242
VAL A 241
PHE A 278
PRO A   6
 None
 1.23A 2q6oB-4rw3A:
undetectable		 2q6oB-4rw3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Synechocystis
sp. PCC 6803) 		PF13561
(adh_short_C2) 		4 ASP A 241
VAL A 245
PRO A 186
THR A 142
 None
 1.32A 2q6oB-4rzhA:
undetectable		 2q6oB-4rzhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 ASP A 159
PRO A 161
THR A 192
TRP A 371
 None
None
AKG  A 501 ( 4.9A)
None
 1.41A 2q6oB-4xgiA:
undetectable		 2q6oB-4xgiA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xoh DIVISION MAL FOUTUE
1 PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 4 ASP C  63
PHE C  66
PRO C  37
THR C  38
 None
 1.43A 2q6oB-4xohC:
undetectable		 2q6oB-4xohC:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		4 ASP A 403
VAL A 399
PRO A 249
THR A 339
 None
 1.24A 2q6oB-4y0xA:
undetectable		 2q6oB-4y0xA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		4 VAL A  47
PHE A 162
THR A 263
TRP A 274
 FAD  A 601 (-4.5A)
None
None
None
 1.41A 2q6oB-4z43A:
undetectable		 2q6oB-4z43A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 ASP A 315
VAL A 317
PHE A 280
THR A 218
 PLP  A 601 (-3.0A)
PLP  A 601 ( 4.3A)
None
None
 1.20A 2q6oB-5ddsA:
undetectable		 2q6oB-5ddsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 ASP A 224
VAL A 362
PRO A 173
THR A 171
 ZN  A 806 (-2.7A)
None
ZN  A 806 ( 4.6A)
None
 1.43A 2q6oB-5e84A:
undetectable		 2q6oB-5e84A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 4 ASP B 200
VAL B 163
PHE B 198
THR B 191
 None
 1.42A 2q6oB-5hdfB:
1.7		 2q6oB-5hdfB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		4 VAL A  48
PHE A 178
THR A 279
TRP A 290
 FAD  A 601 (-4.6A)
None
None
None
 1.35A 2q6oB-5hy5A:
2.7		 2q6oB-5hy5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzl LMO2445 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 ASP B 118
VAL B 142
PHE B 116
PRO B 139
 None
 1.28A 2q6oB-5hzlB:
undetectable		 2q6oB-5hzlB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 VAL A4143
PHE A4106
PRO A4093
THR A4095
 None
 1.17A 2q6oB-5ii5A:
undetectable		 2q6oB-5ii5A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ASP A 301
PHE A  85
PRO A  51
THR A  54
 None
 1.44A 2q6oB-5ipwA:
undetectable		 2q6oB-5ipwA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE

(Plasmodium
falciparum) 		PF07992
(Pyr_redox_2) 		4 PHE A 465
PRO A 432
THR A 433
TRP A 469
 None
 1.37A 2q6oB-5jwbA:
undetectable		 2q6oB-5jwbA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbp GLYCOSYL HYDROLASE,
FAMILY 38

(Enterococcus
faecalis) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 VAL A 450
PHE A 396
PRO A 402
THR A 804
 None
 1.30A 2q6oB-5kbpA:
undetectable		 2q6oB-5kbpA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu5 UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		no annotation 4 VAL A 496
PHE A 459
PRO A 503
THR A 501
 None
PG4  A 705 (-4.6A)
None
None
 1.12A 2q6oB-5mu5A:
undetectable		 2q6oB-5mu5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE
ARSENITE OXIDASE
SMALL SUBUNIT AIOB
RIESKE [2FE-2S]
CLUSTER

(Rhizobium sp.
NT-26;
Rhizobium sp.
NT-26) 		no annotation
no annotation 		4 VAL B 137
PHE A 837
PRO A 779
THR A 780
 None
 1.33A 2q6oB-5nqdB:
undetectable		 2q6oB-5nqdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1

(Homo sapiens) 		no annotation 4 VAL A 248
PHE A 211
PRO A 214
THR A 217
 OLA  A 417 ( 4.9A)
None
9P2  A 401 (-3.8A)
9P2  A 401 (-3.9A)
 1.46A 2q6oB-5o9hA:
undetectable		 2q6oB-5o9hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 4 ASP A 177
VAL A 320
PRO A 126
THR A 124
 MG  A 601 ( 4.9A)
None
None
None
 1.26A 2q6oB-5obuA:
undetectable		 2q6oB-5obuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tky PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		4 ASP A 203
VAL A 341
PRO A 150
THR A 148
 MG  A 701 ( 4.5A)
None
None
None
 1.38A 2q6oB-5tkyA:
undetectable		 2q6oB-5tkyA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		PF04095
(NAPRTase) 		4 VAL A 130
PHE A 440
PRO A 126
THR A  57
 None
 1.34A 2q6oB-5u2nA:
undetectable		 2q6oB-5u2nA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		4 ASP A  98
VAL A 129
PRO A 123
THR A 120
 None
 1.28A 2q6oB-5xn8A:
undetectable		 2q6oB-5xn8A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyu 30S RIBOSOMAL
PROTEIN S6

(Mycolicibacterium
smegmatis) 		PF01250
(Ribosomal_S6) 		4 ASP F  58
VAL F  34
PRO F   6
THR F   7
 None
 1.38A 2q6oB-5xyuF:
undetectable		 2q6oB-5xyuF:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b20 GUANINE
NUCLEOTIDE-BINDING
PROTEIN
G(I)/G(S)/G(T)
SUBUNIT BETA-1

(Bos taurus) 		no annotation 4 ASP A 154
PHE A 151
PRO A 107
THR A  65
 None
 1.35A 2q6oB-6b20A:
undetectable		 2q6oB-6b20A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 4 VAL H 209
PHE H 165
PRO H 141
THR H 139
 None
 1.18A 2q6oB-6df3H:
undetectable		 2q6oB-6df3H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dip NOCTURNIN

(Homo sapiens) 		no annotation 4 VAL A 321
PHE A 280
PRO A 318
THR A 312
 None
 1.26A 2q6oB-6dipA:
undetectable		 2q6oB-6dipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 4 ASP A 224
VAL A 362
PRO A 173
THR A 171
 None
None
SO4  A 602 ( 4.3A)
None
 1.43A 2q6oB-6eoeA:
undetectable		 2q6oB-6eoeA:
19.78