SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q6O_A_SAMA500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c28 PROTEIN (30 KD
ADIPOCYTE
COMPLEMENT-RELATED
PROTEIN PRECURSOR
(ACRP30))

(Mus musculus) 		PF00386
(C1q) 		4 VAL A 174
ALA A 200
PRO A 129
THR A 127
 None
 0.83A 2q6oA-1c28A:
2.0		 2q6oA-1c28A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		4 ASP A 296
ALA A 497
PRO A 230
THR A 269
 None
 1.04A 2q6oA-1cu1A:
undetectable		 2q6oA-1cu1A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		4 ASP A 263
VAL A 264
ALA A 295
PHE A 232
 None
 1.05A 2q6oA-1jikA:
undetectable		 2q6oA-1jikA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 VAL A  98
ALA A 106
PHE A  93
PRO A  92
 None
 1.03A 2q6oA-1mg1A:
undetectable		 2q6oA-1mg1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7n GAG POLYPROTEIN
CAPSID PROTEIN P27

(Rous sarcoma
virus) 		no annotation 4 ASP A  52
VAL A  53
ALA A 136
PRO A  13
 None
 1.05A 2q6oA-1p7nA:
undetectable		 2q6oA-1p7nA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 VAL A  34
ALA A 138
PRO A  31
THR A  27
 None
 0.93A 2q6oA-1q8iA:
undetectable		 2q6oA-1q8iA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Escherichia
coli;
Drosophila
melanogaster) 		no annotation 4 VAL P  96
ALA P 104
PHE P  91
PRO P  90
 None
 0.99A 2q6oA-1r6zP:
undetectable		 2q6oA-1r6zP:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		4 VAL A 149
ALA A   7
PRO A 105
THR A  29
 None
 1.05A 2q6oA-1srdA:
undetectable		 2q6oA-1srdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 VAL A 207
ALA A  27
PRO A 204
THR A  16
 None
 0.99A 2q6oA-1wl4A:
undetectable		 2q6oA-1wl4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 157
ALA A 145
PRO A 124
TRP A 128
 None
 1.04A 2q6oA-2ag1A:
2.2		 2q6oA-2ag1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e67 HYPOTHETICAL PROTEIN
TTHB029

(Thermus
thermophilus) 		PF04794
(YdjC) 		4 VAL A  44
ALA A 115
PRO A  74
THR A  76
 None
 0.99A 2q6oA-2e67A:
undetectable		 2q6oA-2e67A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ASP A 347
VAL A 374
ALA A 377
THR A 322
 None
 0.95A 2q6oA-2f43A:
undetectable		 2q6oA-2f43A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 5 ASP A 247
VAL A 246
ALA A 241
PHE A 283
PRO A   6
 None
 1.32A 2q6oA-2f9rA:
undetectable		 2q6oA-2f9rA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr5 CYTIDINE DEAMINASE

(Mus musculus) 		PF00383
(dCMP_cyt_deam_1) 		4 VAL A  38
ALA A  66
PRO A 120
THR A 118
 TYU  A1001 (-4.1A)
TYU  A1001 (-3.9A)
None
None
 1.00A 2q6oA-2fr5A:
undetectable		 2q6oA-2fr5A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsz TWITCHING MOTILITY
PROTEIN PILT

(Aquifex
aeolicus) 		PF00437
(T2SSE) 		4 ALA A 108
PHE A  48
PRO A  37
THR A  56
 None
 1.06A 2q6oA-2gszA:
2.1		 2q6oA-2gszA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE

(Trypanosoma
brucei) 		PF00365
(PFK) 		4 VAL A 182
ALA A 212
PHE A 135
THR A 195
 None
 1.06A 2q6oA-2higA:
undetectable		 2q6oA-2higA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ond CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT

(Mus musculus) 		PF05843
(Suf) 		4 VAL A 413
ALA A 449
PHE A 398
THR A 375
 None
 0.99A 2q6oA-2ondA:
undetectable		 2q6oA-2ondA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT

(Mus musculus) 		PF05843
(Suf) 		4 VAL A 413
ALA A 449
PHE A 398
THR A 375
 None
 1.04A 2q6oA-2ooeA:
undetectable		 2q6oA-2ooeA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 235
ALA A 358
PHE A  88
THR A 215
 None
 1.06A 2q6oA-2p0uA:
undetectable		 2q6oA-2p0uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pig PUTATIVE TRANSFERASE

(Salmonella
enterica) 		no annotation 4 ASP A  37
VAL A  38
ALA A  31
TRP A  60
 None
 1.00A 2q6oA-2pigA:
undetectable		 2q6oA-2pigA:
23.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		7 ASP A  11
VAL A  12
ALA A  18
PHE A  45
PRO A  73
THR A  75
TRP A 129
 ADN  A 699 (-2.9A)
None
None
ADN  A 699 (-4.4A)
ADN  A 699 (-4.0A)
ADN  A 699 (-3.4A)
None
 0.21A 2q6oA-2q6kA:
40.1		 2q6oA-2q6kA:
99.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		4 ASP A  27
VAL A  26
ALA A 303
THR A 145
 None
 0.98A 2q6oA-2qa2A:
undetectable		 2q6oA-2qa2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7y RIBONUCLEASE H

(Bacillus
halodurans) 		no annotation 4 VAL A  70
ALA A 112
PRO A 128
THR A 176
 None
 0.96A 2q6oA-2r7yA:
undetectable		 2q6oA-2r7yA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		4 ASP A 287
ALA A 350
PHE A 289
PRO A 341
 SO4  A 372 (-3.5A)
None
None
SO4  A 372 ( 4.4A)
 1.06A 2q6oA-2rjoA:
5.5		 2q6oA-2rjoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		4 VAL A  75
ALA A 319
PRO A 252
THR A 255
 None
 1.02A 2q6oA-2uutA:
undetectable		 2q6oA-2uutA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL B 206
ALA B 239
PHE B 214
THR B 518
 None
 0.89A 2q6oA-2w55B:
undetectable		 2q6oA-2w55B:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 VAL A 346
ALA A 529
PHE A 316
THR A 311
 None
 0.94A 2q6oA-2waeA:
undetectable		 2q6oA-2waeA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		4 ASP A 383
ALA A 133
PRO A 284
THR A 287
 None
 0.94A 2q6oA-2z3tA:
undetectable		 2q6oA-2z3tA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 ASP A 270
VAL A 269
ALA A 341
THR A 257
 None
 1.02A 2q6oA-2ztgA:
3.4		 2q6oA-2ztgA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		4 VAL A 178
ALA A 171
PRO A 144
THR A 257
 None
 1.00A 2q6oA-2zvbA:
undetectable		 2q6oA-2zvbA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		4 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
 0.81A 2q6oA-3a3cA:
undetectable		 2q6oA-3a3cA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		5 VAL A  40
ALA A 151
PHE A 126
PRO A 127
THR A 120
 None
 1.20A 2q6oA-3al0A:
undetectable		 2q6oA-3al0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 ASP A 783
VAL A 768
PHE A 148
THR A 734
 None
 1.06A 2q6oA-3egwA:
2.6		 2q6oA-3egwA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f67 PUTATIVE
DIENELACTONE
HYDROLASE

(Klebsiella
pneumoniae) 		PF01738
(DLH) 		4 ALA A 101
PHE A  66
PRO A  16
THR A   6
 None
None
EDO  A 239 ( 4.9A)
None
 1.02A 2q6oA-3f67A:
2.6		 2q6oA-3f67A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 225
PHE A 334
PRO A 222
THR A 313
 None
 1.00A 2q6oA-3g5wA:
undetectable		 2q6oA-3g5wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ged SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Ruminiclostridium
thermocellum) 		PF13561
(adh_short_C2) 		4 VAL A 105
ALA A  83
PRO A  59
THR A  61
 None
THJ  A 249 ( 4.1A)
None
None
 1.07A 2q6oA-3gedA:
undetectable		 2q6oA-3gedA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goh ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Shewanella
oneidensis) 		PF08240
(ADH_N) 		4 ASP A  64
VAL A  63
PRO A 126
THR A 129
 None
 0.99A 2q6oA-3gohA:
undetectable		 2q6oA-3gohA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp5 PUTATIVE CELL
SURFACE HYDROLASE

(Lactobacillus
plantarum) 		PF06028
(DUF915) 		4 VAL A 187
ALA A 171
PHE A 151
THR A 112
 None
 0.86A 2q6oA-3lp5A:
2.6		 2q6oA-3lp5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE

(Amycolatopsis
balhimycina) 		PF00067
(p450) 		4 VAL A  48
ALA A  53
PRO A 305
THR A 289
 None
 0.97A 2q6oA-3mgxA:
undetectable		 2q6oA-3mgxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0t DIPEPTIDYL PEPTIDASE
2

(Homo sapiens) 		PF05577
(Peptidase_S28) 		4 VAL A 205
ALA A 270
PHE A 359
PRO A 335
 None
 1.08A 2q6oA-3n0tA:
undetectable		 2q6oA-3n0tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		4 VAL A 383
ALA A 341
PRO A 446
THR A 448
 None
 0.98A 2q6oA-3nz4A:
undetectable		 2q6oA-3nz4A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		4 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
 1.03A 2q6oA-3osrA:
2.1		 2q6oA-3osrA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppx VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		4 ALA A1634
PHE A1520
PRO A1658
THR A1656
 None
 1.03A 2q6oA-3ppxA:
3.9		 2q6oA-3ppxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE

(Escherichia
coli) 		PF03629
(SASA) 		4 ASP A  71
VAL A  72
ALA A 139
THR A  14
 None
 0.95A 2q6oA-3pt5A:
2.1		 2q6oA-3pt5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw3 AMINOPEPTIDASE C

(Parabacteroides
distasonis) 		PF03051
(Peptidase_C1_2) 		4 VAL A 389
ALA A 259
PHE A 111
THR A 384
 None
None
EDO  A 434 ( 3.8A)
None
 0.95A 2q6oA-3pw3A:
undetectable		 2q6oA-3pw3A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsq CAPSID POLYPROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		4 ASP A 620
VAL A 619
PHE A 524
THR A 591
 None
 1.00A 2q6oA-3qsqA:
undetectable		 2q6oA-3qsqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 VAL A 396
ALA A  21
PRO A 271
THR A 363
 None
 1.00A 2q6oA-3sdoA:
undetectable		 2q6oA-3sdoA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8j PURINE NUCLEOSIDASE,
(IUNH-1)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		4 VAL A  31
ALA A  47
PHE A 118
THR A 242
 None
 0.99A 2q6oA-3t8jA:
2.3		 2q6oA-3t8jA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx8 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Corynebacterium
glutamicum) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 VAL A 323
ALA A 333
PRO A 166
THR A 167
 None
 1.03A 2q6oA-3tx8A:
undetectable		 2q6oA-3tx8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vk5 MOEO5

(Streptomyces
viridosporus) 		PF01884
(PcrB) 		4 VAL A  95
ALA A  64
PRO A 118
THR A 155
 None
None
FPQ  A 900 ( 4.7A)
None
 1.08A 2q6oA-3vk5A:
undetectable		 2q6oA-3vk5A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbd SINGLE CHAIN FV
FRAGMENT OF MAB735

(Mus musculus) 		PF07686
(V-set) 		4 VAL A 139
ALA A 143
PRO A 136
THR A 238
 None
 0.94A 2q6oA-3wbdA:
undetectable		 2q6oA-3wbdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 ASP A 270
VAL A 269
ALA A 341
THR A 257
 None
 1.04A 2q6oA-3wqyA:
3.2		 2q6oA-3wqyA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		4 ASP A 307
ALA A 430
PRO A 378
THR A 376
 None
 0.92A 2q6oA-3zyiA:
undetectable		 2q6oA-3zyiA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD

(Pseudomonas
aeruginosa) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 VAL A 230
ALA A 209
PRO A 265
THR A 267
 None
 1.04A 2q6oA-4a5oA:
3.4		 2q6oA-4a5oA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Escherichia
coli;
Macaca mulatta) 		PF00622
(SPRY)
PF01547
(SBP_bac_1) 		4 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
 1.00A 2q6oA-4b3nA:
undetectable		 2q6oA-4b3nA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		4 VAL A  98
ALA A 106
PHE A  93
PRO A  92
 None
 1.00A 2q6oA-4blaA:
2.3		 2q6oA-4blaA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
 1.07A 2q6oA-4dxbA:
undetectable		 2q6oA-4dxbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A1183
ALA A1243
PRO A1180
THR A1271
 None
 0.99A 2q6oA-4e9xA:
undetectable		 2q6oA-4e9xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		4 VAL A  93
ALA A 105
PHE A 130
PRO A 119
 None
 0.93A 2q6oA-4eb5A:
undetectable		 2q6oA-4eb5A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbl LIPS LIPOLYTIC
ENZYME

(unidentified) 		PF12146
(Hydrolase_4) 		4 ASP A 227
VAL A 230
ALA A 152
THR A 260
 None
None
CL  A 302 ( 4.8A)
None
 1.08A 2q6oA-4fblA:
2.8		 2q6oA-4fblA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggp TRANS-2-ENOYL-COA
REDUCTASE

(Treponema
denticola) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 ALA A 280
PHE A 169
PRO A 164
THR A 244
 None
 1.05A 2q6oA-4ggpA:
undetectable		 2q6oA-4ggpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 ASP A-173
VAL A-174
ALA A -20
THR A 576
 None
 0.90A 2q6oA-4h1gA:
undetectable		 2q6oA-4h1gA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 281
ALA A 290
PRO A 309
TRP A 306
 None
None
GOL  A 402 (-4.2A)
None
 1.08A 2q6oA-4hnlA:
undetectable		 2q6oA-4hnlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1d ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF13416
(SBP_bac_8) 		4 VAL A 100
ALA A  82
PHE A 288
TRP A  97
 None
 0.95A 2q6oA-4i1dA:
undetectable		 2q6oA-4i1dA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9f GLYCEROL 3-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 VAL A 283
ALA A 331
PRO A 268
TRP A 272
 None
 1.02A 2q6oA-4i9fA:
undetectable		 2q6oA-4i9fA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iul EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02854
(MIF4G) 		4 ASP A 183
VAL A 182
ALA A 203
THR A 234
 None
 1.05A 2q6oA-4iulA:
undetectable		 2q6oA-4iulA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 232
ALA A 242
PRO A 211
THR A 186
 None
 0.81A 2q6oA-4j6fA:
undetectable		 2q6oA-4j6fA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
None
MG  A1302 (-4.7A)
MG  A1302 (-3.6A)
 1.08A 2q6oA-4kegA:
undetectable		 2q6oA-4kegA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 VAL A 181
ALA A 216
PHE A 274
THR A 194
 None
 1.07A 2q6oA-4mrmA:
3.3		 2q6oA-4mrmA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 VAL A 362
ALA A 376
PHE A 244
THR A 251
 None
 1.03A 2q6oA-4oqjA:
undetectable		 2q6oA-4oqjA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqh GLUTATHIONE
TRANSFERASE LAMBDA1

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 ASP A 172
VAL A 171
ALA A 119
PRO A 162
 None
 0.92A 2q6oA-4pqhA:
undetectable		 2q6oA-4pqhA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 ASP A 179
VAL A 178
ALA A 124
PRO A 168
 None
 0.99A 2q6oA-4pqiA:
undetectable		 2q6oA-4pqiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		4 ASP A 378
VAL A 381
ALA A 437
THR A 429
 None
 1.06A 2q6oA-4pxqA:
undetectable		 2q6oA-4pxqA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		4 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
 1.08A 2q6oA-4xa2A:
2.1		 2q6oA-4xa2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC

(Chlamydomonas
reinhardtii) 		no annotation 4 ALA A 146
PHE A  94
PRO A 316
THR A 317
 None
 1.02A 2q6oA-5b5xA:
undetectable		 2q6oA-5b5xA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Escherichia
coli;
Acinetobacter
nosocomialis) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		4 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
 1.07A 2q6oA-5cfvA:
undetectable		 2q6oA-5cfvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		4 ASP B 106
VAL B 107
ALA B 161
PHE B  99
 None
 0.91A 2q6oA-5d3mB:
undetectable		 2q6oA-5d3mB:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di0 NATTERIN-LIKE
PROTEIN

(Danio rerio) 		PF03318
(ETX_MTX2) 		4 VAL A 153
ALA A 215
PRO A 275
TRP A 199
 None
 1.05A 2q6oA-5di0A:
undetectable		 2q6oA-5di0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyi NON-STRUCTURAL
PROTEIN 11

(Porcine
reproductive
and respiratory
syndrome virus) 		no annotation 4 ASP A 134
VAL A 140
ALA A 173
THR A 217
 None
None
None
CL  A 302 (-3.5A)
 1.00A 2q6oA-5eyiA:
undetectable		 2q6oA-5eyiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3j ANTIBODY 2D10 SINGLE
CHAIN VARIABLE
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 VAL C 181
ALA C 185
PRO C 178
THR C 283
 None
 0.90A 2q6oA-5f3jC:
undetectable		 2q6oA-5f3jC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6z SANDERCYANIN
FLUORESCENT PROTEIN

(Sander vitreus) 		PF08212
(Lipocalin_2) 		4 VAL A  32
ALA A 102
PHE A 167
PRO A  28
 None
 0.91A 2q6oA-5f6zA:
undetectable		 2q6oA-5f6zA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		4 VAL A-275
ALA A-267
PHE A-280
PRO A-281
 None
 0.84A 2q6oA-5fsgA:
undetectable		 2q6oA-5fsgA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 VAL A  98
ALA A 106
PHE A  93
PRO A  92
 None
 1.05A 2q6oA-5gpqA:
undetectable		 2q6oA-5gpqA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 VAL A 464
ALA A 472
PHE A 459
PRO A 458
 None
 1.07A 2q6oA-5hzvA:
undetectable		 2q6oA-5hzvA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		4 VAL A 152
ALA A 160
PHE A 147
PRO A 146
 None
 1.02A 2q6oA-5hzwA:
undetectable		 2q6oA-5hzwA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd0 ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00620
(RhoGAP) 		4 VAL A1076
ALA A1004
PRO A1061
THR A1066
 None
 1.07A 2q6oA-5jd0A:
undetectable		 2q6oA-5jd0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 4 VAL C  97
ALA C 105
PHE C  92
PRO C  91
 None
 1.08A 2q6oA-5jj4C:
2.2		 2q6oA-5jj4C:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 VAL A 886
ALA A 891
PRO A 926
THR A 927
 None
 0.87A 2q6oA-5kf7A:
undetectable		 2q6oA-5kf7A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 VAL A 685
ALA A 666
PRO A 689
THR A 691
 None
None
U  E   1 ( 4.1A)
None
 1.07A 2q6oA-5ltaA:
undetectable		 2q6oA-5ltaA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora) 		no annotation 4 VAL A  31
ALA A  42
PRO A  89
TRP A  63
 None
 0.95A 2q6oA-5no5A:
undetectable		 2q6oA-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofq CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		4 ALA A 138
PHE A 391
PRO A 286
THR A 281
 None
 1.08A 2q6oA-5ofqA:
undetectable		 2q6oA-5ofqA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		4 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
 1.08A 2q6oA-5tj2A:
2.2		 2q6oA-5tj2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Desulfovibrio
vulgaris) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A  48
ALA A  42
PHE A 308
PRO A  90
 None
 0.99A 2q6oA-5tx7A:
2.7		 2q6oA-5tx7A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE

(Escherichia
coli;
Serratia
marcescens) 		no annotation 4 VAL A  99
ALA A 107
PHE A  94
PRO A  93
 None
 0.95A 2q6oA-5wvmA:
undetectable		 2q6oA-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 VAL A 719
ALA A 702
PRO A 723
THR A 725
 None
 0.92A 2q6oA-5xdrA:
undetectable		 2q6oA-5xdrA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypt STILBENECARBOXYLATE
SYNTHASE 1

(Marchantia
polymorpha) 		no annotation 4 ASP A 219
ALA A 342
PHE A  72
THR A 199
 None
 1.07A 2q6oA-5yptA:
undetectable		 2q6oA-5yptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN

(Escherichia
coli) 		no annotation 4 VAL A  98
ALA A 106
PHE A  93
PRO A  92
 None
 1.01A 2q6oA-5z0rA:
undetectable		 2q6oA-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ax8 METHIONINE-TRNA
LIGASE

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A 492
ALA A 489
PRO A 496
THR A 498
 None
 0.90A 2q6oA-6ax8A:
undetectable		 2q6oA-6ax8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 4 VAL A 153
ALA A 161
PRO A 430
THR A 434
 None
 1.01A 2q6oA-6bf6A:
undetectable		 2q6oA-6bf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 4 VAL A 183
ALA A 227
PRO A  96
THR A  35
 None
None
None
THR  A 401 (-3.0A)
 1.07A 2q6oA-6f8yA:
undetectable		 2q6oA-6f8yA:
undetectable