SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q6H_A_CXXA801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		5 ARG A 155
ILE A 167
PHE A 159
PHE A 130
LEU A 100
 None
 1.13A 2q6hA-1bs9A:
undetectable		 2q6hA-1bs9A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF06325
(PrmA) 		5 LEU 1 138
LEU 1 139
ILE 1 168
PHE 1 237
LEU 1 307
 None
 1.20A 2q6hA-1g6q1:
0.0		 2q6hA-1g6q1:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 267
ARG A 274
ILE A 215
LEU A 173
ASP A 171
 None
 1.19A 2q6hA-1h4lA:
0.0		 2q6hA-1h4lA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens) 		PF09128
(RGS-like) 		5 LEU F 324
LEU F 317
ARG F 320
PHE F 311
LEU F 436
 None
 1.02A 2q6hA-1htjF:
0.0		 2q6hA-1htjF:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 LEU A 663
GLN A 669
ILE A  25
PHE A  29
LEU A 737
 None
 1.25A 2q6hA-1j1wA:
0.1		 2q6hA-1j1wA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		PF00561
(Abhydrolase_1)
no annotation 		5 LEU D 149
VAL D 145
ILE E 289
ASP E 263
ASP E 287
 None
None
None
None
CA  E 320 (-3.4A)
 1.27A 2q6hA-1qgeD:
0.0		 2q6hA-1qgeD:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE

(Trichoderma
reesei) 		PF01083
(Cutinase) 		5 ARG A 155
ILE A 167
PHE A 159
PHE A 130
LEU A 100
 None
 1.20A 2q6hA-1qozA:
undetectable		 2q6hA-1qozA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkt PROTEIN YFIR

(Bacillus
subtilis) 		PF00440
(TetR_N) 		5 LEU A  75
LEU A 141
ILE A  88
PHE A 134
LEU A 196
 None
 1.18A 2q6hA-1rktA:
0.5		 2q6hA-1rktA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rty YVQK PROTEIN

(Bacillus
subtilis) 		PF01923
(Cob_adeno_trans) 		5 LEU A  67
VAL A  90
ILE A  33
LEU A  74
ASP A  73
 None
 0.99A 2q6hA-1rtyA:
undetectable		 2q6hA-1rtyA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 LEU A 225
LEU A 228
ARG A 226
ILE A 203
ASP A 262
 None
 1.00A 2q6hA-1szsA:
0.0		 2q6hA-1szsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9i DNA ENDONUCLEASE
I-CREI

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		5 LEU A  78
GLN A  44
ILE A  62
PHE A  87
LEU A  13
 None
 1.18A 2q6hA-1t9iA:
undetectable		 2q6hA-1t9iA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 LEU A 346
GLN A 352
ILE A 256
PHE A 324
LEU A 313
 None
 1.28A 2q6hA-1tmoA:
undetectable		 2q6hA-1tmoA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		5 LEU C 896
LEU C 892
VAL C 885
ILE C 932
LEU C 958
 None
 1.25A 2q6hA-1u6gC:
undetectable		 2q6hA-1u6gC:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU A  54
ILE A  51
PHE A  79
PHE A 150
LEU A  75
 None
 1.15A 2q6hA-1v0bA:
undetectable		 2q6hA-1v0bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF14681
(UPRTase) 		5 LEU A 101
LEU A 141
ILE A  99
LEU A 128
ASP A 130
 None
None
None
None
SO4  A 517 ( 4.1A)
 1.21A 2q6hA-1v9sA:
undetectable		 2q6hA-1v9sA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwp HYPOTHETICAL PROTEIN
TTHA0636

(Thermus
thermophilus) 		PF08780
(NTase_sub_bind) 		5 LEU A 117
LEU A 114
ARG A 116
GLN A 112
PHE A  37
 None
 1.22A 2q6hA-1wwpA:
undetectable		 2q6hA-1wwpA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 LEU A 347
LEU A 346
LEU A  27
ASP A  24
ASP A  28
 None
 1.20A 2q6hA-1xrcA:
0.7		 2q6hA-1xrcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		5 LEU A  21
LEU A  15
ILE A 155
LEU A 119
ASP A 123
 None
 1.25A 2q6hA-1yd9A:
undetectable		 2q6hA-1yd9A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389

(Mycobacterium
tuberculosis) 		PF13523
(Acetyltransf_8) 		5 LEU A  94
LEU A  45
ARG A  46
LEU A  56
ASP A  52
 None
 1.18A 2q6hA-1yk3A:
undetectable		 2q6hA-1yk3A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5i AZO REDUCTASE

(Escherichia
coli) 		PF02525
(Flavodoxin_2) 		5 LEU A   6
GLN A 103
ILE A  91
PHE A 108
LEU A 156
 None
 1.28A 2q6hA-2d5iA:
undetectable		 2q6hA-2d5iA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 177
LEU A 191
ILE A 179
PHE A 143
LEU A 159
 None
 1.16A 2q6hA-2ft3A:
undetectable		 2q6hA-2ft3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 LEU A 162
LEU A 183
ARG A 184
GLN A 252
ILE A 160
 None
None
FAD  A2001 (-3.9A)
FAD  A2001 (-4.7A)
None
 1.24A 2q6hA-2g37A:
undetectable		 2q6hA-2g37A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		5 LEU A  31
LEU A  39
GLN A  37
ILE A  73
PHE A  61
 None
 1.26A 2q6hA-2g9bA:
undetectable		 2q6hA-2g9bA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5c 1,8-CINEOLE SYNTHASE

(Salvia
fruticosa) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ARG A 325
ILE A  92
PHE A 124
LEU A 272
ASP A 276
 BME  A1592 ( 4.0A)
None
None
None
None
 0.84A 2q6hA-2j5cA:
undetectable		 2q6hA-2j5cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j85 STIV B116

(Sulfolobus
turreted
icosahedral
virus 1) 		PF08960
(DUF1874) 		5 LEU A  57
LEU A  61
ILE A  84
PHE A  32
LEU A   6
 None
 1.07A 2q6hA-2j85A:
undetectable		 2q6hA-2j85A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5c UNCHARACTERIZED
PROTEIN PF0385

(Pyrococcus
furiosus) 		PF03966
(Trm112p) 		5 LEU A  77
LEU A  94
ILE A  24
PHE A  81
LEU A  28
 None
 1.24A 2q6hA-2k5cA:
undetectable		 2q6hA-2k5cA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 233
LEU A 273
GLN A 270
ILE A 186
LEU A 212
 None
 1.28A 2q6hA-2uxtA:
undetectable		 2q6hA-2uxtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 LEU A 742
LEU A 744
ILE A 769
PHE A 758
LEU A 714
 None
 1.03A 2q6hA-2v26A:
2.3		 2q6hA-2v26A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 268
LEU A 272
ILE A 313
PHE A 299
LEU A 297
 None
 1.27A 2q6hA-2v55A:
undetectable		 2q6hA-2v55A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3z PUTATIVE DEACETYLASE

(Streptococcus
mutans) 		PF01522
(Polysacc_deac_1) 		5 LEU A 290
VAL A 243
ILE A 125
PHE A 113
LEU A 129
 None
 1.08A 2q6hA-2w3zA:
undetectable		 2q6hA-2w3zA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 LEU A  22
ARG A  24
ILE A  19
LEU A  37
ASP A  38
 None
 1.28A 2q6hA-2w8sA:
undetectable		 2q6hA-2w8sA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 LEU A 432
ARG A 417
VAL A 414
GLN A 415
ASP A 390
 None
 1.23A 2q6hA-2wnwA:
undetectable		 2q6hA-2wnwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 LEU A  74
LEU A  76
VAL A  78
PHE A 218
LEU A 185
 None
 1.23A 2q6hA-2xpzA:
undetectable		 2q6hA-2xpzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 LEU A 774
LEU A 771
ARG A 773
ILE A 798
ASP A 789
 None
 1.22A 2q6hA-2yocA:
undetectable		 2q6hA-2yocA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvl HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF08704
(GCD14) 		5 LEU A 240
LEU A 189
VAL A 166
ILE A  83
LEU A  87
 None
None
SAM  A 601 ( 4.3A)
None
None
 1.28A 2q6hA-2yvlA:
undetectable		 2q6hA-2yvlA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 LEU A1302
VAL A1309
GLN A1311
ILE A1590
LEU A1154
 None
None
None
None
SAM  A   1 (-4.7A)
 1.16A 2q6hA-3av6A:
undetectable		 2q6hA-3av6A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8p CHAIN LENGTH
DETERMINANT PROTEIN

(Salmonella
enterica) 		PF02706
(Wzz) 		5 LEU A 130
LEU A 132
VAL A 134
ILE A  96
ASP A 156
 None
 1.22A 2q6hA-3b8pA:
0.2		 2q6hA-3b8pA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqh PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB

(Neisseria
meningitidis) 		PF01625
(PMSR) 		5 LEU A 309
ARG A 311
ILE A 305
LEU A 263
ASP A 264
 None
 1.25A 2q6hA-3bqhA:
undetectable		 2q6hA-3bqhA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Saccharomyces
cerevisiae) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 368
GLN A 370
ILE A 147
PHE A  47
PHE A 399
 None
 1.24A 2q6hA-3btuA:
undetectable		 2q6hA-3btuA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 LEU A 425
ARG A 427
ILE A 414
LEU A 474
ASP A 470
 None
 1.23A 2q6hA-3cemA:
0.5		 2q6hA-3cemA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd9 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF16806
(ExsD) 		5 LEU A 220
LEU A 221
ILE A 120
PHE A 229
LEU A 125
 None
 1.20A 2q6hA-3fd9A:
undetectable		 2q6hA-3fd9A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkf ALDOLASE LSRF

(Escherichia
coli) 		no annotation 5 LEU O  78
LEU O  54
VAL O  84
ILE O  75
PHE O  56
 None
 1.26A 2q6hA-3gkfO:
undetectable		 2q6hA-3gkfO:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1

(Staphylococcus
aureus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 186
GLN A 174
ILE A 272
PHE A 299
LEU A 261
 None
 0.79A 2q6hA-3h3jA:
undetectable		 2q6hA-3h3jA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ial PROLYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 LEU A 383
ARG A 407
ILE A  55
PHE A  39
ASP A 311
 None
 0.99A 2q6hA-3ialA:
undetectable		 2q6hA-3ialA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ism CG4930

(Drosophila
melanogaster) 		PF08785
(Ku_PK_bind) 		5 LEU C  39
VAL C  44
GLN C  45
ILE C  27
LEU C  91
 None
 1.19A 2q6hA-3ismC:
1.2		 2q6hA-3ismC:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP3

(Parechovirus B) 		PF00073
(Rhv) 		5 LEU C 201
VAL C  75
GLN C 224
ILE C 203
PHE C  90
 None
 1.18A 2q6hA-3jb4C:
undetectable		 2q6hA-3jb4C:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jui TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Homo sapiens) 		PF02020
(W2) 		5 LEU A 646
LEU A 676
ILE A 649
PHE A 670
LEU A 601
 None
 1.28A 2q6hA-3juiA:
undetectable		 2q6hA-3juiA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Bacillus cereus) 		PF01923
(Cob_adeno_trans) 		5 LEU A  66
VAL A  89
ILE A  33
LEU A  73
ASP A  72
 None
 1.06A 2q6hA-3ke5A:
undetectable		 2q6hA-3ke5A:
18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		10 LEU A  25
LEU A  29
VAL A  33
GLN A  34
ILE A 111
PHE A 253
PHE A 320
LEU A 400
ASP A 401
ASP A 404
 LEU  A 601 (-4.9A)
None
None
None
None
LEU  A 601 (-4.2A)
None
None
None
None
 0.25A 2q6hA-3mpnA:
68.1		 2q6hA-3mpnA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00202
(Aminotran_3) 		5 LEU A 205
LEU A 208
ARG A 206
ILE A 183
ASP A 242
 None
 1.01A 2q6hA-3nx3A:
undetectable		 2q6hA-3nx3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 LEU A 254
ARG A 258
ILE A 227
PHE A 267
ASP A 222
 None
 1.26A 2q6hA-3opbA:
undetectable		 2q6hA-3opbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A  30
VAL A  40
ILE A  46
PHE A  57
LEU A  78
 None
 1.06A 2q6hA-3p11A:
undetectable		 2q6hA-3p11A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		5 LEU A1299
VAL A1306
GLN A1308
ILE A1588
LEU A1151
 None
None
None
None
SAH  A1601 (-3.6A)
 1.13A 2q6hA-3ptaA:
undetectable		 2q6hA-3ptaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Yersinia pestis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A  42
LEU A  44
VAL A 159
ILE A 112
LEU A 121
 None
 1.26A 2q6hA-3pyzA:
1.6		 2q6hA-3pyzA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q62 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Yersinia pestis) 		PF07977
(FabA) 		5 ARG A   5
VAL A   2
ILE A  40
LEU A  13
ASP A  12
 None
 1.09A 2q6hA-3q62A:
undetectable		 2q6hA-3q62A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q62 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Yersinia pestis) 		PF07977
(FabA) 		5 ARG A   5
VAL A   2
ILE A  40
PHE A  93
ASP A  12
 None
 1.13A 2q6hA-3q62A:
undetectable		 2q6hA-3q62A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhq SAG0897 FAMILY
CRISPR-ASSOCIATED
PROTEIN

(Streptococcus
agalactiae) 		PF09711
(Cas_Csn2) 		5 LEU A  21
LEU A 196
ILE A   4
PHE A  36
LEU A  47
 None
 1.18A 2q6hA-3qhqA:
undetectable		 2q6hA-3qhqA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ARG A 370
ILE A 120
PHE A 372
LEU A 549
ASP A 553
 None
 0.74A 2q6hA-3s9vA:
undetectable		 2q6hA-3s9vA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 365
GLN A 355
ILE A 241
LEU A 499
ASP A 498
 None
 1.20A 2q6hA-3vskA:
undetectable		 2q6hA-3vskA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x43 O-UREIDO-L-SERINE
SYNTHASE

(Streptomyces
lavendulae) 		PF00291
(PALP) 		5 LEU A 189
VAL A 235
GLN A 187
ILE A 160
PHE A 172
 None
 1.15A 2q6hA-3x43A:
undetectable		 2q6hA-3x43A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		5 LEU A 223
LEU A 226
ARG A 224
ILE A 201
ASP A 259
 None
 1.04A 2q6hA-4e77A:
undetectable		 2q6hA-4e77A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eku PROTEIN-TYROSINE
KINASE 2-BETA

(Homo sapiens) 		PF00373
(FERM_M) 		5 LEU A 176
ILE A 231
PHE A 227
LEU A 210
ASP A 211
 None
 1.22A 2q6hA-4ekuA:
undetectable		 2q6hA-4ekuA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		5 VAL A  54
ILE A 157
PHE A 260
LEU A 232
ASP A 236
 None
 1.24A 2q6hA-4g1cA:
undetectable		 2q6hA-4g1cA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7v VOLTAGE-SENSOR
CONTAINING
PHOSPHATASE

(Ciona
intestinalis) 		PF00520
(Ion_trans) 		5 LEU S 224
ARG S 226
VAL S 196
LEU S 137
ASP S 136
 None
 1.23A 2q6hA-4g7vS:
undetectable		 2q6hA-4g7vS:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 223
LEU A 247
GLN A 268
LEU A 218
ASP A 220
 None
 1.25A 2q6hA-4mn8A:
undetectable		 2q6hA-4mn8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL

(Homo sapiens) 		PF01230
(HIT) 		5 LEU A  60
ILE A  92
PHE A  56
LEU A  90
ASP A  80
 None
None
None
None
SO4  A 201 (-2.8A)
 1.22A 2q6hA-4njzA:
undetectable		 2q6hA-4njzA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		PF09084
(NMT1) 		5 LEU A  25
ILE A  39
PHE A 211
PHE A  22
LEU A  10
 None
 1.28A 2q6hA-4nmyA:
undetectable		 2q6hA-4nmyA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		5 LEU A 588
LEU A 574
ILE A 522
ASP A 515
ASP A 581
 None
 1.27A 2q6hA-4pjuA:
undetectable		 2q6hA-4pjuA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgk FATTY ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		5 LEU A  27
LEU A  30
VAL A  34
GLN A  35
ASP A  69
 None
 1.12A 2q6hA-4qgkA:
undetectable		 2q6hA-4qgkA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Aliivibrio
fischeri) 		PF00092
(VWA) 		5 LEU A  63
LEU A  20
VAL A  22
ILE A  55
ASP A  90
 None
 0.96A 2q6hA-4rckA:
undetectable		 2q6hA-4rckA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 LEU A 114
ARG A 117
GLN A 116
ILE A  60
ASP A  69
 None
 1.10A 2q6hA-4u1rA:
0.0		 2q6hA-4u1rA:
23.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		6 LEU A  29
ARG A  34
ILE A 111
PHE A 230
ASP A 382
ASP A 385
 None
None
None
TRP  A 601 (-4.4A)
None
None
 0.91A 2q6hA-4us4A:
3.1		 2q6hA-4us4A:
32.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvw GALECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		5 LEU A  26
VAL A  61
GLN A  50
ILE A  32
LEU A  34
 None
 1.26A 2q6hA-4wvwA:
undetectable		 2q6hA-4wvwA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 LEU A 826
LEU A 808
ILE A 786
PHE A 807
LEU A 769
 None
 1.03A 2q6hA-4xmvA:
0.3		 2q6hA-4xmvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc7 FORMIN-LIKE PROTEIN
2

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 LEU B 265
LEU B 269
VAL B 273
ILE B 225
LEU B 140
 None
 1.28A 2q6hA-4yc7B:
undetectable		 2q6hA-4yc7B:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydh FORMIN-LIKE PROTEIN
1

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 LEU A 271
LEU A 275
VAL A 279
ILE A 231
LEU A 154
 None
 1.26A 2q6hA-4ydhA:
undetectable		 2q6hA-4ydhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 719
LEU A 705
VAL A 707
GLN A 715
ILE A 664
 None
 1.23A 2q6hA-4yhcA:
undetectable		 2q6hA-4yhcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby CLEAVED PEPTIDE
SEPARASE

(Chaetomium
thermophilum;
synthetic
construct) 		PF03568
(Peptidase_C50)
no annotation 		5 LEU A1988
LEU A1985
VAL B  15
GLN B  18
ILE A1956
 None
 1.24A 2q6hA-5fbyA:
undetectable		 2q6hA-5fbyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 LEU A  52
GLN A 226
ILE A 110
PHE A 238
LEU A 112
 None
 1.21A 2q6hA-5h42A:
undetectable		 2q6hA-5h42A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		5 LEU A 372
LEU A 376
ARG A 373
ILE A 306
ASP A 277
 None
 1.16A 2q6hA-5h5mA:
undetectable		 2q6hA-5h5mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		5 LEU A 297
ARG A 296
ILE A 337
LEU A 287
ASP A 285
 None
None
None
EDO  A 509 (-4.1A)
None
 0.99A 2q6hA-5jijA:
undetectable		 2q6hA-5jijA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 LEU A 232
LEU A 271
ILE A 305
PHE A 262
LEU A 277
 None
 1.14A 2q6hA-5k8rA:
undetectable		 2q6hA-5k8rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		5 LEU B  81
VAL B  79
ILE B 333
PHE B 281
ASP B 233
 None
 1.21A 2q6hA-5l9wB:
undetectable		 2q6hA-5l9wB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE

(Pseudomonas
mendocina) 		PF11927
(DUF3445) 		5 LEU A 182
LEU A  83
ARG A 183
LEU A  75
ASP A  78
 None
 1.20A 2q6hA-5ltiA:
undetectable		 2q6hA-5ltiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10

(Schizosaccharomyces
pombe) 		PF09748
(Med10) 		5 LEU B  48
LEU B  28
PHE B  25
LEU B  55
ASP B  54
 None
 1.27A 2q6hA-5n9jB:
undetectable		 2q6hA-5n9jB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 205
GLN A 211
ILE A 146
PHE A 244
LEU A 158
 None
 0.94A 2q6hA-5opjA:
undetectable		 2q6hA-5opjA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szp PROTOCADHERIN GAMMA
B7

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 LEU A 110
ILE A 200
PHE A 148
LEU A 170
ASP A 116
 None
 1.15A 2q6hA-5szpA:
undetectable		 2q6hA-5szpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 5 LEU B  90
LEU B  87
ILE B  47
LEU B 316
ASP B 315
 None
 1.11A 2q6hA-5thzB:
undetectable		 2q6hA-5thzB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjt MAJOR CAPSID PROTEIN

(Escherichia
virus T5) 		PF05065
(Phage_capsid) 		5 LEU A 271
LEU A 275
ARG A 272
VAL A 421
ILE A 255
 None
 1.26A 2q6hA-5tjtA:
undetectable		 2q6hA-5tjtA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 284
LEU A 288
ILE A 329
PHE A 315
LEU A 313
 None
 1.21A 2q6hA-5u7qA:
undetectable		 2q6hA-5u7qA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG

(Bombyx mori) 		PF00567
(TUDOR) 		5 GLN A  19
ILE A 192
PHE A  20
PHE A  16
LEU A 194
 None
 1.21A 2q6hA-5vqhA:
undetectable		 2q6hA-5vqhA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 5 LEU A 398
VAL A 413
ILE A 401
PHE A 367
LEU A 324
 None
 1.25A 2q6hA-5w21A:
undetectable		 2q6hA-5w21A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5f TAIL TUBE PROTEIN
GP19

(Enterobacteria
phage T4 sensu
lato) 		PF06841
(Phage_T4_gp19) 		5 LEU A 132
LEU A 157
VAL A 137
GLN A  89
ILE A  25
 None
 1.16A 2q6hA-5w5fA:
undetectable		 2q6hA-5w5fA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 LEU A 259
LEU A 272
ILE A 257
PHE A 304
LEU A 286
 None
 1.18A 2q6hA-5xdrA:
undetectable		 2q6hA-5xdrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 5 LEU A 822
LEU A1094
VAL A1001
GLN A1004
LEU A 815
 None
 1.27A 2q6hA-6b3rA:
undetectable		 2q6hA-6b3rA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3y DENN
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		no annotation 5 LEU A 879
LEU A 864
ILE A 820
PHE A 875
LEU A 829
 None
 1.22A 2q6hA-6b3yA:
undetectable		 2q6hA-6b3yA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5e GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 209
ARG A 208
VAL A 202
GLN A 206
ASP A 176
 None
 1.14A 2q6hA-6b5eA:
undetectable		 2q6hA-6b5eA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7j 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Vibrio cholerae) 		no annotation 5 ARG A   5
ILE A  40
PHE A  93
LEU A  13
ASP A  12
 None
 1.02A 2q6hA-6b7jA:
undetectable		 2q6hA-6b7jA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0b TOXIN B

(Clostridioides
difficile) 		no annotation 5 LEU A1647
GLN A1620
ILE A1684
PHE A1623
LEU A1566
 None
 1.19A 2q6hA-6c0bA:
undetectable		 2q6hA-6c0bA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z UPF0434 FAMILY
PROTEIN

(Haloferax
volcanii) 		no annotation 5 LEU C  20
LEU C  35
ARG C  34
ILE C  30
ASP C  23
 GOL  C 101 (-4.4A)
GOL  C 101 (-4.8A)
None
None
None
 1.11A 2q6hA-6f5zC:
undetectable		 2q6hA-6f5zC:
8.84