SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q64_B_1UNB1001_4
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkh | MUCONATE LACTONIZINGENZYME (Pseudomonasputida) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | ASP A 204THR A 242PRO A 243 | None | 0.52A | 2q64B-1bkhA:undetectable | 2q64B-1bkhA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ecx | AMINOTRANSFERASE (Thermotogamaritima) |
PF00266(Aminotran_5) | 3 | ASP A 160THR A 95PRO A 96 | None | 0.66A | 2q64B-1ecxA:undetectable | 2q64B-1ecxA:13.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g01 | ENDOGLUCANASE (Bacillus sp.KSM-635) |
PF00150(Cellulase)PF03424(CBM_17_28) | 3 | ASP A 577THR A 532PRO A 533 | None | 0.54A | 2q64B-1g01A:undetectable | 2q64B-1g01A:14.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | A79 A 800 (-2.7A)NoneA79 A 800 ( 3.4A) | 0.26A | 2q64B-1hvcA:14.0 | 2q64B-1hvcA:97.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | A79 A 800 (-2.8A)NoneA79 A 800 ( 3.9A) | 0.43A | 2q64B-1hvcA:14.0 | 2q64B-1hvcA:97.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1keh | PRECURSOR OFCEPHALOSPORINACYLASE (Brevundimonasdiminuta) |
PF01804(Penicil_amidase) | 3 | ASP A 589THR A 619PRO A 620 | None | 0.47A | 2q64B-1kehA:undetectable | 2q64B-1kehA:9.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lg7 | VSV MATRIX PROTEIN (Vesicularstomatitisvirus) |
PF06326(Vesiculo_matrix) | 3 | ASP A 223THR A 148PRO A 149 | None | 0.63A | 2q64B-1lg7A:undetectable | 2q64B-1lg7A:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1np3 | KETOL-ACIDREDUCTOISOMERASE (Pseudomonasaeruginosa) |
PF01450(IlvC)PF07991(IlvN) | 3 | ASP A 65THR A 80PRO A 81 | None | 0.64A | 2q64B-1np3A:undetectable | 2q64B-1np3A:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nrw | HYPOTHETICALPROTEIN, HALOACIDDEHALOGENASE-LIKEHYDROLASE (Bacillussubtilis) |
PF08282(Hydrolase_3) | 3 | ASP A 124THR A 111PRO A 112 | None | 0.62A | 2q64B-1nrwA:undetectable | 2q64B-1nrwA:16.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | None | 0.65A | 2q64B-1q9pA:10.3 | 2q64B-1q9pA:92.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | None | 0.29A | 2q64B-1sivA:18.5 | 2q64B-1sivA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulq | PUTATIVE ACETYL-COAACETYLTRANSFERASE (Thermusthermophilus) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 3 | ASP A 27THR A 12PRO A 13 | None | 0.63A | 2q64B-1ulqA:undetectable | 2q64B-1ulqA:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wvi | PUTATIVEPHOSPHATASESINVOLVED INN-ACETYL-GLUCOSAMINECATABOLISM (Streptococcusmutans) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 3 | ASP A1026THR A1064PRO A1065 | None | 0.64A | 2q64B-1wviA:undetectable | 2q64B-1wviA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wy7 | HYPOTHETICAL PROTEINPH1948 (Pyrococcushorikoshii) |
PF05175(MTS) | 3 | ASP A 130THR A 30PRO A 31 | NoneSAH A1001 (-4.0A)None | 0.58A | 2q64B-1wy7A:undetectable | 2q64B-1wy7A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xe7 | HYPOTHETICAL 22.5KDA PROTEIN INTUB1-CPR3 INTERGENICREGION (Saccharomycescerevisiae) |
PF06172(Cupin_5) | 3 | ASP A 36THR A 87PRO A 88 | None | 0.54A | 2q64B-1xe7A:undetectable | 2q64B-1xe7A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xkh | FERRIPYOVERDINERECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | ASP A 244THR A 192PRO A 193 | None | 0.53A | 2q64B-1xkhA:undetectable | 2q64B-1xkhA:9.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yln | HYPOTHETICAL PROTEINVCA0042 (Vibrio cholerae) |
PF07238(PilZ)PF12945(YcgR_2) | 3 | ASP A 79THR A 48PRO A 49 | None | 0.66A | 2q64B-1ylnA:undetectable | 2q64B-1ylnA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yw6 | SUCCINYLGLUTAMATEDESUCCINYLASE (Escherichiacoli) |
PF04952(AstE_AspA) | 3 | ASP A 134THR A 37PRO A 38 | None | 0.66A | 2q64B-1yw6A:undetectable | 2q64B-1yw6A:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a2o | HYPOTHETICAL PROTEINBT3146 (Bacteroidesthetaiotaomicron) |
no annotation | 3 | ASP A 57THR A 179PRO A 180 | None | 0.64A | 2q64B-2a2oA:undetectable | 2q64B-2a2oA:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2adv | GLUTARYL 7-AMINOCEPHALOSPORANICACID ACYLASE (Pseudomonas sp.SY-77-1) |
PF01804(Penicil_amidase) | 3 | ASP C 420THR C 450PRO C 451 | None | 0.57A | 2q64B-2advC:undetectable | 2q64B-2advC:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d6f | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT D (Methanothermobacterthermautotrophicus) |
PF00710(Asparaginase) | 3 | ASP A 298THR A 193PRO A 194 | None | 0.66A | 2q64B-2d6fA:undetectable | 2q64B-2d6fA:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7z | ACETYLENE HYDRATASEAHY (Pelobacteracetylenicus) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 3 | ASP A 13THR A 40PRO A 41 | MGD A 802 (-3.2A)MPD A1004 (-3.4A)MPD A1004 ( 4.9A) | 0.53A | 2q64B-2e7zA:undetectable | 2q64B-2e7zA:10.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fuq | HEPARINASE IIPROTEIN (Pedobacterheparinus) |
PF07940(Hepar_II_III)PF16332(DUF4962) | 3 | ASP A 480THR A 657PRO A 658 | NoneNonePO4 A 944 ( 4.9A) | 0.53A | 2q64B-2fuqA:undetectable | 2q64B-2fuqA:8.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gdu | SUCROSEPHOSPHORYLASE (Bifidobacteriumadolescentis) |
PF00128(Alpha-amylase)PF09244(DUF1964) | 3 | ASP A 127THR A 208PRO A 209 | None | 0.47A | 2q64B-2gduA:undetectable | 2q64B-2gduA:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i50 | UBIQUITINCARBOXYL-TERMINALHYDROLASE 16 (Homo sapiens) |
PF02148(zf-UBP) | 3 | ASP A 37THR A 80PRO A 81 | None | 0.63A | 2q64B-2i50A:undetectable | 2q64B-2i50A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kdn | PUTATIVEUNCHARACTERIZEDPROTEIN PFE0790C (Plasmodiumfalciparum) |
PF01722(BolA) | 3 | ASP A 71THR A 96PRO A 97 | None | 0.51A | 2q64B-2kdnA:undetectable | 2q64B-2kdnA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nvv | ACETYL-COAHYDROLASE/TRANSFERASE FAMILY PROTEIN (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 3 | ASP A 413THR A 393PRO A 394 | ASP A 413 (-0.5A)THR A 393 ( 0.8A)PRO A 394 ( 1.1A) | 0.60A | 2q64B-2nvvA:undetectable | 2q64B-2nvvA:12.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5p | FERRIPYOVERDINERECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07660(STN)PF07715(Plug) | 3 | ASP A 244THR A 192PRO A 193 | None | 0.54A | 2q64B-2o5pA:undetectable | 2q64B-2o5pA:8.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o8e | DNA MISMATCH REPAIRPROTEIN MSH6 (Homo sapiens) |
PF00488(MutS_V)PF01624(MutS_I)PF05188(MutS_II)PF05190(MutS_IV)PF05192(MutS_III) | 3 | ASP B1026THR B 488PRO B 489 | None | 0.66A | 2q64B-2o8eB:undetectable | 2q64B-2o8eB:7.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2odf | HYPOTHETICAL PROTEINATU2144 (Agrobacteriumfabrum) |
PF05013(FGase) | 3 | ASP A 50THR A 157PRO A 158 | None | 0.48A | 2q64B-2odfA:undetectable | 2q64B-2odfA:18.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | AB1 A 501 ( 3.3A)NoneAB1 A 501 (-4.2A) | 0.38A | 2q64B-2rkfA:21.4 | 2q64B-2rkfA:85.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vf8 | EXCINUCLEASE ABCSUBUNIT A (Deinococcusradiodurans) |
PF00005(ABC_tran) | 3 | ASP A 688THR A 619PRO A 620 | None | 0.54A | 2q64B-2vf8A:undetectable | 2q64B-2vf8A:8.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9m | POLYMERASE X (Deinococcusradiodurans) |
PF14520(HHH_5)PF14716(HHH_8) | 3 | ASP A 295THR A 284PRO A 285 | None | 0.67A | 2q64B-2w9mA:undetectable | 2q64B-2w9mA:10.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhg | TYROCIDINESYNTHETASE A (Brevibacillusbrevis) |
PF00668(Condensation) | 3 | ASP A 181THR A 20PRO A 21 | None | 0.36A | 2q64B-2xhgA:undetectable | 2q64B-2xhgA:12.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ze0 | ALPHA-GLUCOSIDASE (Geobacillus sp.HTA-462) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 3 | ASP A 376THR A 412PRO A 413 | None | 0.66A | 2q64B-2ze0A:undetectable | 2q64B-2ze0A:10.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aw5 | MULTICOPPER OXIDASE (Pyrobaculumaerophilum) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 3 | ASP A 241THR A 288PRO A 289 | None | 0.58A | 2q64B-3aw5A:undetectable | 2q64B-3aw5A:12.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emy | TRICHODERMA REESEIASPARTIC PROTEASE (Trichodermareesei) |
PF00026(Asp) | 3 | ASP A 37THR A 45PRO A 46 | None | 0.52A | 2q64B-3emyA:6.6 | 2q64B-3emyA:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fw8 | RETICULINE OXIDASE (Eschscholziacalifornica) |
PF01565(FAD_binding_4)PF08031(BBE) | 3 | ASP A 196THR A 404PRO A 405 | None | 0.60A | 2q64B-3fw8A:undetectable | 2q64B-3fw8A:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1b | ATP-DEPENDENT CLPPROTEASE ADAPTERPROTEIN CLPS (Caulobactervibrioides) |
PF02617(ClpS) | 3 | ASP A 103THR A 51PRO A 52 | None | 0.44A | 2q64B-3g1bA:undetectable | 2q64B-3g1bA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hx6 | TYPE 4 FIMBRIALBIOGENESIS PROTEINPILY1 (Pseudomonasaeruginosa) |
PF05567(Neisseria_PilC) | 3 | ASP A1030THR A1059PRO A1060 | None | 0.66A | 2q64B-3hx6A:undetectable | 2q64B-3hx6A:10.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ijt | PUTATIVEUNCHARACTERIZEDPROTEIN (Streptococcusmutans) |
no annotation | 3 | ASP A 123THR A 77PRO A 78 | None | 0.66A | 2q64B-3ijtA:undetectable | 2q64B-3ijtA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ing | HOMOSERINEDEHYDROGENASE (Thermoplasmaacidophilum) |
PF00742(Homoserine_dh)PF03447(NAD_binding_3) | 3 | ASP A 76THR A 89PRO A 90 | NoneNDP A 326 (-4.6A)NDP A 326 (-4.0A) | 0.54A | 2q64B-3ingA:undetectable | 2q64B-3ingA:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iuu | PUTATIVEMETALLOPEPTIDASE (Chelativoranssp. BNC1) |
PF07171(MlrC_C)PF07364(DUF1485) | 3 | ASP A 237THR A 144PRO A 145 | None | 0.45A | 2q64B-3iuuA:undetectable | 2q64B-3iuuA:13.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9b | LIVERCARBOXYLESTERASE 1 (Homo sapiens) |
PF00135(COesterase) | 3 | ASP A1260THR A1331PRO A1332 | None | 0.64A | 2q64B-3k9bA:undetectable | 2q64B-3k9bA:11.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd8 | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Thermoplasmaacidophilum) |
PF01676(Metalloenzyme)PF10143(PhosphMutase) | 3 | ASP A 351THR A 24PRO A 25 | None | 0.66A | 2q64B-3kd8A:undetectable | 2q64B-3kd8A:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lkd | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLTRANSFERASESUBUNIT (Streptococcusthermophilus) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 3 | ASP A 336THR A 201PRO A 202 | None | 0.63A | 2q64B-3lkdA:undetectable | 2q64B-3lkdA:12.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | None | 0.37A | 2q64B-3mwsA:19.8 | 2q64B-3mwsA:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ndn | O-SUCCINYLHOMOSERINESULFHYDRYLASE (Mycobacteriumtuberculosis) |
PF01053(Cys_Met_Meta_PP) | 3 | ASP A 354THR A 199PRO A 200 | None | 0.52A | 2q64B-3ndnA:undetectable | 2q64B-3ndnA:13.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nwg | MICROCOMPARTMENTSPROTEIN (Desulfitobacteriumhafniense) |
PF00936(BMC) | 3 | ASP A 112THR A 88PRO A 89 | None | 0.56A | 2q64B-3nwgA:undetectable | 2q64B-3nwgA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pc8 | DNA LIGASE 3 (Homo sapiens) |
PF16759(LIG3_BRCT) | 3 | ASP C 896THR C 862PRO C 863 | None | 0.58A | 2q64B-3pc8C:undetectable | 2q64B-3pc8C:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q2i | DEHYDROGENASE (Chromobacteriumviolaceum) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 3 | ASP A 67THR A 81PRO A 82 | NoneNAI A 500 (-4.7A)NAI A 500 (-4.5A) | 0.66A | 2q64B-3q2iA:undetectable | 2q64B-3q2iA:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qb5 | TRANSLIN-ASSOCIATEDPROTEIN X (Homo sapiens) |
PF01997(Translin) | 3 | ASP K 112THR K 183PRO K 184 | None | 0.46A | 2q64B-3qb5K:undetectable | 2q64B-3qb5K:17.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | 017 A 201 (-3.5A)NoneNone | 0.38A | 2q64B-3t3cA:18.6 | 2q64B-3t3cA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | 017 A 201 (-3.3A)None017 A 201 (-4.1A) | 0.26A | 2q64B-3ttpA:19.8 | 2q64B-3ttpA:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | 017 A 201 (-3.2A)None017 A 202 (-4.0A) | 0.16A | 2q64B-3u7sA:20.1 | 2q64B-3u7sA:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubr | CYTOCHROME C-552 (Shewanellaoneidensis) |
PF02335(Cytochrom_C552) | 3 | ASP A 404THR A 250PRO A 251 | None | 0.67A | 2q64B-3ubrA:undetectable | 2q64B-3ubrA:13.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | None | 0.59A | 2q64B-3uhlA:16.3 | 2q64B-3uhlA:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ulx | STRESS-INDUCEDTRANSCRIPTION FACTORNAC1 (Oryza sativa) |
PF02365(NAM) | 3 | ASP A 58THR A 74PRO A 75 | None | 0.66A | 2q64B-3ulxA:undetectable | 2q64B-3ulxA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wgp | VITAMIN D3 RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 3 | ASP A 149THR A 415PRO A 416 | None | 0.67A | 2q64B-3wgpA:undetectable | 2q64B-3wgpA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wo0 | ALANINE-ANTICAPSINLIGASE BACD (Bacillussubtilis) |
PF13535(ATP-grasp_4) | 3 | ASP A 450THR A 266PRO A 267 | None | 0.56A | 2q64B-3wo0A:undetectable | 2q64B-3wo0A:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zk4 | DIPHOSPHONUCLEOTIDEPHOSPHATASE 1 (Lupinus luteus) |
PF00149(Metallophos)PF14008(Metallophos_C)PF16656(Pur_ac_phosph_N) | 3 | ASP A 159THR A 190PRO A 191 | None | 0.46A | 2q64B-3zk4A:undetectable | 2q64B-3zk4A:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b2o | YMDBPHOSPHODIESTERASE (Bacillussubtilis) |
PF13277(YmdB) | 3 | ASP A 61THR A 142PRO A 143 | None | 0.62A | 2q64B-4b2oA:undetectable | 2q64B-4b2oA:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c13 | UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--L-LYSINE LIGASE (Staphylococcusaureus) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 3 | ASP A 444THR A 404PRO A 405 | None | 0.63A | 2q64B-4c13A:undetectable | 2q64B-4c13A:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fqz | GALECTIN-8 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 3 | ASP A 44THR A 95PRO A 96 | None | 0.62A | 2q64B-4fqzA:undetectable | 2q64B-4fqzA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igl | YENB (Yersiniaentomophaga) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 3 | ASP A 978THR A1469PRO A1470 | None | 0.63A | 2q64B-4iglA:undetectable | 2q64B-4iglA:5.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kam | O-ACETYLHOMOSERINESULFHYDRYLASE METC (Mycobacteriummarinum) |
PF01053(Cys_Met_Meta_PP) | 3 | ASP A 382THR A 200PRO A 201 | None | 0.59A | 2q64B-4kamA:undetectable | 2q64B-4kamA:12.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kv3 | CHIMERA FUSIONPROTEIN OF ESX-1SECRETION SYSTEMPROTEIN ECCD1 ANDMALTOSE-BINDINGPERIPLASMIC PROTEIN (Escherichiacoli;Mycobacteriumtuberculosis) |
PF08817(YukD)PF13416(SBP_bac_8) | 3 | ASP A 387THR A 414PRO A 415 | None | 0.67A | 2q64B-4kv3A:undetectable | 2q64B-4kv3A:11.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4muo | UNCHARACTERIZEDPROTEIN YBIB (Escherichiacoli) |
PF02885(Glycos_trans_3N) | 3 | ASP A 246THR A 189PRO A 190 | None | 0.66A | 2q64B-4muoA:undetectable | 2q64B-4muoA:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n5f | PUTATIVE ACYL-COADEHYDROGENASE (Burkholderiacenocepacia) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 3 | ASP A 222THR A 190PRO A 191 | None | 0.54A | 2q64B-4n5fA:undetectable | 2q64B-4n5fA:12.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | RIT A 500 (-3.2A)NoneRIT A 500 (-3.9A) | 0.26A | 2q64B-4njvA:20.6 | 2q64B-4njvA:85.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pwo | DSBA (Corynebacteriumdiphtheriae) |
PF13462(Thioredoxin_4) | 3 | ASP A 105THR A 283PRO A 284 | None | 0.43A | 2q64B-4pwoA:undetectable | 2q64B-4pwoA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z5q | CYTOCHROME P450HYDROXYLASE (Streptomycesatroolivaceus) |
PF00067(p450) | 3 | ASP A 220THR A 109PRO A 110 | None | 0.63A | 2q64B-4z5qA:undetectable | 2q64B-4z5qA:12.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zg5 | 5'-NUCLEOTIDASE SURE (Brucellaabortus) |
no annotation | 3 | ASP D 217THR D 232PRO D 233 | None | 0.60A | 2q64B-4zg5D:undetectable | 2q64B-4zg5D:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5brq | GLYCOSIDE HYDROLASEFAMILY 13 (Bacilluslicheniformis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 3 | ASP A 378THR A 419PRO A 420 | None | 0.43A | 2q64B-5brqA:undetectable | 2q64B-5brqA:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5brq | GLYCOSIDE HYDROLASEFAMILY 13 (Bacilluslicheniformis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 3 | ASP A 379THR A 419PRO A 420 | None | 0.58A | 2q64B-5brqA:undetectable | 2q64B-5brqA:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6d | UBIQUITINCARBOXYL-TERMINALHYDROLASE 7 (Homo sapiens) |
PF12436(USP7_ICP0_bdg) | 3 | ASP A 722THR A 707PRO A 708 | ASP A 722 ( 0.6A)THR A 707 ( 0.8A)PRO A 708 ( 1.1A) | 0.64A | 2q64B-5c6dA:undetectable | 2q64B-5c6dA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gkq | ALYGC MUTANT - R241A (Paraglaciecolachathamensis) |
PF14592(Chondroitinas_B) | 3 | ASP A 617THR A 703PRO A 704 | None | 0.37A | 2q64B-5gkqA:undetectable | 2q64B-5gkqA:8.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hab | RIBONUCLEASE J (Methanolobuspsychrophilus) |
PF07521(RMMBL)PF12706(Lactamase_B_2) | 3 | ASP A 188THR A 105PRO A 106 | None | 0.37A | 2q64B-5habA:undetectable | 2q64B-5habA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ic7 | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
no annotation | 3 | ASP A 262THR A 585PRO A 586 | NoneSO4 A 701 (-2.6A)SO4 A 706 (-4.4A) | 0.41A | 2q64B-5ic7A:undetectable | 2q64B-5ic7A:14.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idk | GENOMEPOLYPROTEIN,SERINEPROTEASE SUBUNITNS2B, SERINEPROTEASE NS3 (West Nile virus) |
PF00949(Peptidase_S7)PF01002(Flavi_NS2B) | 3 | ASP A1075THR A1118PRO A1119 | 6A8 A1201 ( 4.2A)NoneNone | 0.67A | 2q64B-5idkA:undetectable | 2q64B-5idkA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5isx | GRAMICIDIN SSYNTHASE 1 (Brevibacillusbrevis) |
PF00550(PP-binding)PF00668(Condensation) | 3 | ASP A 788THR A 627PRO A 628 | None | 0.48A | 2q64B-5isxA:undetectable | 2q64B-5isxA:11.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ix8 | PUTATIVE SUGAR ABCTRANSPORT SYSTEM,SUBSTRATE-BINDINGPROTEIN (Bordetellaparapertussis) |
PF13407(Peripla_BP_4) | 3 | ASP A 232THR A 245PRO A 246 | None | 0.67A | 2q64B-5ix8A:undetectable | 2q64B-5ix8A:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l46 | DIMETHYLGLYCINEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF01266(DAO)PF01571(GCV_T)PF08669(GCV_T_C)PF16350(FAO_M) | 3 | ASP A 428THR A 572PRO A 573 | None | 0.66A | 2q64B-5l46A:undetectable | 2q64B-5l46A:8.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m6p | TYROCIDINE SYNTHASE2 (Brevibacillusparabrevis) |
no annotation | 3 | ASP A3290THR A3129PRO A3130 | None | 0.35A | 2q64B-5m6pA:undetectable | 2q64B-5m6pA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5med | ARACHIDONATE15-LIPOXYGENASE (Cyanothece sp.PCC 8801) |
PF00305(Lipoxygenase) | 3 | ASP A 136THR A 230PRO A 231 | None | 0.59A | 2q64B-5medA:undetectable | 2q64B-5medA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mh5 | D-2-HYDROXYACIDDEHYDROGENASE (Haloferaxmediterranei) |
no annotation | 3 | ASP A 181THR A 197PRO A 198 | NoneNAP A 414 (-4.4A)NAP A 414 (-3.4A) | 0.60A | 2q64B-5mh5A:undetectable | 2q64B-5mh5A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ot1 | PULLULANASE TYPE II,GH13 FAMILY (Thermococcuskodakarensis) |
no annotation | 3 | ASP A 498THR A 639PRO A 640 | None | 0.65A | 2q64B-5ot1A:undetectable | 2q64B-5ot1A:16.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | None | 0.23A | 2q64B-5t2zA:20.4 | 2q64B-5t2zA:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tkm | DNA DC->DU-EDITINGENZYME APOBEC-3B (Homo sapiens) |
PF08210(APOBEC_N) | 3 | ASP A 149THR A 95PRO A 96 | None | 0.65A | 2q64B-5tkmA:undetectable | 2q64B-5tkmA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr8 | 441D6 FAB HEAVYCHAIN (Mus musculus) |
no annotation | 3 | ASP H 61THR H 40PRO H 41 | None | 0.59A | 2q64B-5tr8H:undetectable | 2q64B-5tr8H:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2a | AMP-DEPENDENTSYNTHETASE ANDLIGASE (Brucella canis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 3 | ASP A 429THR A 534PRO A 535 | None | 0.66A | 2q64B-5u2aA:undetectable | 2q64B-5u2aA:11.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u30 | CRISPR-ASSOCIATEDENDONUCLEASE C2C1 (Alicyclobacillusacidoterrestris) |
no annotation | 3 | ASP A 736THR A 685PRO A 686 | None | 0.51A | 2q64B-5u30A:undetectable | 2q64B-5u30A:6.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uzb | TOLL/INTERLEUKIN-1RECEPTORDOMAIN-CONTAININGADAPTER PROTEIN (Homo sapiens) |
PF13676(TIR_2) | 3 | ASP A 102THR A 148PRO A 149 | None | 0.54A | 2q64B-5uzbA:undetectable | 2q64B-5uzbA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wy0 | SMALL RNA2'-O-METHYLTRANSFERASE (Homo sapiens) |
no annotation | 3 | ASP A 111THR A 132PRO A 133 | None | 0.52A | 2q64B-5wy0A:undetectable | 2q64B-5wy0A:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbl | CRISPR-ASSOCIATEDENDONUCLEASECAS9/CSN1 (Streptococcuspyogenes) |
PF13395(HNH_4)PF16592(Cas9_REC)PF16593(Cas9-BH)PF16595(Cas9_PI) | 3 | ASP A 269THR A 249PRO A 250 | G B 19 ( 4.9A)NoneNone | 0.65A | 2q64B-5xblA:undetectable | 2q64B-5xblA:6.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfa | NAD-REDUCINGHYDROGENASE (Hydrogenophilusthermoluteolus) |
PF01257(2Fe-2S_thioredx)PF01512(Complex1_51K)PF10589(NADH_4Fe-4S) | 3 | ASP A 69THR A 58PRO A 59 | None | 0.39A | 2q64B-5xfaA:undetectable | 2q64B-5xfaA:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtb | NADH DEHYDROGENASE[UBIQUINONE]FLAVOPROTEIN 2,MITOCHONDRIAL (Homo sapiens) |
PF01257(2Fe-2S_thioredx) | 3 | ASP O 206THR O 164PRO O 165 | None | 0.63A | 2q64B-5xtbO:undetectable | 2q64B-5xtbO:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6blb | HOLLIDAY JUNCTIONATP-DEPENDENT DNAHELICASE RUVB (Pseudomonasaeruginosa) |
no annotation | 3 | ASP A 300THR A 220PRO A 221 | NoneNoneADP A 401 (-4.4A) | 0.66A | 2q64B-6blbA:undetectable | 2q64B-6blbA:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
no annotation | 3 | ASP A 347THR A 395PRO A 396 | None | 0.53A | 2q64B-6c66A:undetectable | 2q64B-6c66A:20.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 3 | ASP A 29THR A 80PRO A 81 | None | 0.51A | 2q64B-6upjA:18.0 | 2q64B-6upjA:47.47 |