SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q63_A_1UNA1001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akm ORNITHINE
TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ARG A 246
ASN A 256
THR A 230
 None
 0.85A 2q63A-1akmA:
0.0		 2q63A-1akmA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bix AP ENDONUCLEASE 1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 ARG A 254
ASN A 212
THR A 265
 None
 0.74A 2q63A-1bixA:
0.0		 2q63A-1bixA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		3 ARG A 118
ASN A 155
THR A 124
 None
 0.72A 2q63A-1c4oA:
0.0		 2q63A-1c4oA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		3 ARG A 147
ASN A  35
THR A  74
 None
 0.85A 2q63A-1eceA:
0.0		 2q63A-1eceA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		3 ARG A 109
ASN A 449
THR A 455
 None
 0.76A 2q63A-1fohA:
0.0		 2q63A-1fohA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 ARG A 842
ASN A 831
THR A 767
 None
 0.84A 2q63A-1g8xA:
undetectable		 2q63A-1g8xA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		3 ARG A  26
ASN A 195
THR A 240
 None
 0.80A 2q63A-1hwnA:
0.0		 2q63A-1hwnA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		3 ARG A  45
ASN A 483
THR A 546
 None
 0.85A 2q63A-1m1cA:
0.0		 2q63A-1m1cA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ARG A 331
ASN A 360
THR A 335
 None
 0.86A 2q63A-1np7A:
0.0		 2q63A-1np7A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nui DNA PRIMASE/HELICASE

(Escherichia
virus T7) 		PF08273
(Prim_Zn_Ribbon)
PF13155
(Toprim_2) 		3 ARG A 124
ASN A  70
THR A 133
 None
 0.83A 2q63A-1nuiA:
undetectable		 2q63A-1nuiA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz1 GENERAL STRESS
PROTEIN 69

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		3 ARG A  76
ASN A 109
THR A  83
 None
 0.68A 2q63A-1pz1A:
undetectable		 2q63A-1pz1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjj ACTININ

(Gallus gallus) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		3 ARG A 476
ASN A 486
THR A 411
 None
 0.87A 2q63A-1sjjA:
undetectable		 2q63A-1sjjA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ARG B 200
ASN B 249
THR B 254
 None
 0.76A 2q63A-1umbB:
undetectable		 2q63A-1umbB:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ARG A 257
ASN A 328
THR A 264
 ARG  A 257 ( 0.6A)
ASN  A 328 ( 0.6A)
THR  A 264 ( 0.8A)
 0.85A 2q63A-1wqaA:
undetectable		 2q63A-1wqaA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygg PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Actinobacillus
succinogenes) 		PF01293
(PEPCK_ATP) 		3 ARG A 333
ASN A 296
THR A 255
 None
None
SO4  A4121 (-3.7A)
 0.80A 2q63A-1yggA:
undetectable		 2q63A-1yggA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjd T-CELL-SPECIFIC
SURFACE GLYCOPROTEIN
CD28

(Homo sapiens) 		PF15910
(V-set_2) 		3 ARG C  34
ASN C  67
THR C  64
 None
 0.84A 2q63A-1yjdC:
undetectable		 2q63A-1yjdC:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 ARG E 216
ASN E 224
THR E 275
 None
 0.75A 2q63A-2bg9E:
undetectable		 2q63A-2bg9E:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		3 ARG A 387
ASN A 416
THR A 224
 None
 0.86A 2q63A-2bmfA:
undetectable		 2q63A-2bmfA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		3 ARG A 561
ASN A 612
THR A 605
 None
 0.69A 2q63A-2cjqA:
undetectable		 2q63A-2cjqA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		3 ARG A 261
ASN A 268
THR A 243
 None
 0.87A 2q63A-2e4uA:
undetectable		 2q63A-2e4uA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		3 ARG A 387
ASN A 277
THR A 242
 BSC  A   2 (-2.6A)
None
BSC  A   2 (-3.7A)
 0.88A 2q63A-2gwcA:
undetectable		 2q63A-2gwcA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc4 EXODEOXYRIBONUCLEASE
III

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		3 ARG A 189
ASN A 148
THR A 199
 None
ACT  A1260 ( 4.7A)
None
 0.89A 2q63A-2jc4A:
undetectable		 2q63A-2jc4A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio) 		PF03372
(Exo_endo_phos) 		3 ARG A 246
ASN A 205
THR A 257
 None
 0.74A 2q63A-2o3cA:
undetectable		 2q63A-2o3cA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot9 HYPOTHETICAL PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF07152
(YaeQ) 		3 ARG A 101
ASN A 123
THR A 176
 None
 0.87A 2q63A-2ot9A:
undetectable		 2q63A-2ot9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg2 CHOLOYLGLYCINE
HYDROLASE

(Clostridium
perfringens) 		PF02275
(CBAH) 		3 ARG A 231
ASN A 297
THR A 276
 None
 0.83A 2q63A-2rg2A:
undetectable		 2q63A-2rg2A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 ARG A 182
ASN A 147
THR A 192
 None
GOL  A1240 (-2.9A)
None
 0.80A 2q63A-2v0sA:
undetectable		 2q63A-2v0sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 ARG A 348
ASN A 290
THR A 384
 None
 0.79A 2q63A-2x0qA:
undetectable		 2q63A-2x0qA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		3 ARG A 802
ASN A 921
THR A 913
 EDO  A1943 ( 4.0A)
None
None
 0.82A 2q63A-2yhgA:
undetectable		 2q63A-2yhgA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yof THYMIDYLATE KINASE

(Plasmodium
falciparum) 		PF02223
(Thymidylate_kin) 		3 ARG A  99
ASN A 113
THR A 158
 74W  A 211 (-4.0A)
None
None
 0.67A 2q63A-2yofA:
undetectable		 2q63A-2yofA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		3 ARG A 431
ASN A 446
THR A 593
 None
 0.86A 2q63A-2zpaA:
undetectable		 2q63A-2zpaA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		3 ARG A 285
ASN A 250
THR A 258
 None
 0.83A 2q63A-3abbA:
undetectable		 2q63A-3abbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		3 ARG A 661
ASN A 764
THR A 770
 None
 0.61A 2q63A-3apoA:
undetectable		 2q63A-3apoA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw9 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Pyrobaculum
calidifontis) 		PF01370
(Epimerase) 		3 ARG A 203
ASN A 162
THR A 298
 None
GDU  A 801 ( 2.7A)
None
 0.70A 2q63A-3aw9A:
undetectable		 2q63A-3aw9A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 ARG X  93
ASN X 237
THR X 215
 None
BGC  X 501 (-3.8A)
None
 0.88A 2q63A-3b8aX:
undetectable		 2q63A-3b8aX:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 ARG A 802
ASN A 555
THR A 996
 None
 0.89A 2q63A-3bgaA:
undetectable		 2q63A-3bgaA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 126
ASN A 156
THR A  30
 None
 0.74A 2q63A-3dkhA:
undetectable		 2q63A-3dkhA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 ARG A 231
ASN A 725
THR A 226
 None
 0.77A 2q63A-3ecqA:
undetectable		 2q63A-3ecqA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcz POSSIBLE
THIOL-DISULFIDE
ISOMERASE

(Cytophaga
hutchinsonii) 		PF00578
(AhpC-TSA) 		3 ARG A 350
ASN A 447
THR A 360
 None
 0.78A 2q63A-3hczA:
undetectable		 2q63A-3hczA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Nitrosospira
multiformis) 		PF00365
(PFK) 		3 ARG A  43
ASN A   5
THR A  57
 None
 0.71A 2q63A-3hnoA:
undetectable		 2q63A-3hnoA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3C

(Saccharomyces
cerevisiae) 		PF00203
(Ribosomal_S19) 		3 ARG p 716
ASN p 686
THR p 724
 None
 0.83A 2q63A-3japp:
undetectable		 2q63A-3japp:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5r CADHERIN 13

(Mus musculus) 		PF00028
(Cadherin) 		3 ARG A 145
ASN A 103
THR A 139
 None
 0.73A 2q63A-3k5rA:
undetectable		 2q63A-3k5rA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6y CATENIN DELTA-1

(Homo sapiens) 		PF00514
(Arm) 		3 ARG A 729
ASN A 715
THR A 768
 None
 0.87A 2q63A-3l6yA:
undetectable		 2q63A-3l6yA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpm PUTATIVE
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF05175
(MTS) 		3 ARG A 180
ASN A 173
THR A 158
 None
 0.83A 2q63A-3lpmA:
undetectable		 2q63A-3lpmA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		3 ARG A 405
ASN A 436
THR A 123
 None
 0.82A 2q63A-3lx6A:
undetectable		 2q63A-3lx6A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxq UNCHARACTERIZED
PROTEIN VP1736

(Vibrio
parahaemolyticus) 		PF00884
(Sulfatase) 		3 ARG A 534
ASN A 542
THR A 548
 None
 0.85A 2q63A-3lxqA:
undetectable		 2q63A-3lxqA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		3 ARG A 102
ASN A 235
THR A  96
 None
 0.70A 2q63A-3m7dA:
undetectable		 2q63A-3m7dA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		3 ARG A 405
ASN A 436
THR A 123
 None
 0.82A 2q63A-3me5A:
undetectable		 2q63A-3me5A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding) 		3 ARG A 216
ASN A 327
THR A 332
 None
 0.75A 2q63A-3pbkA:
undetectable		 2q63A-3pbkA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qva TRANSTHYRETIN-LIKE
PROTEIN

(Klebsiella
pneumoniae) 		PF00576
(Transthyretin) 		3 ARG A  76
ASN A  -6
THR A  30
 None
 0.64A 2q63A-3qvaA:
undetectable		 2q63A-3qvaA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		3 ARG A 172
ASN A 195
THR A 191
 None
 0.77A 2q63A-3rm5A:
undetectable		 2q63A-3rm5A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7i FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Bacillus
anthracis) 		PF02525
(Flavodoxin_2) 		3 ARG A 209
ASN A  38
THR A   4
 None
 0.89A 2q63A-3u7iA:
undetectable		 2q63A-3u7iA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 ARG B 249
ASN B 397
THR B 488
 SO4  B1201 (-3.3A)
None
SO4  B1195 ( 4.0A)
 0.80A 2q63A-3v0aB:
undetectable		 2q63A-3v0aB:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkw REPLICASE LARGE
SUBUNIT

(Tobacco mosaic
virus) 		PF01443
(Viral_helicase1) 		3 ARG A1076
ASN A 978
THR A 966
 SO4  A1203 (-2.7A)
None
None
 0.78A 2q63A-3vkwA:
undetectable		 2q63A-3vkwA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ARG A 566
ASN A 555
THR A 609
 None
 0.67A 2q63A-3vrbA:
undetectable		 2q63A-3vrbA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		3 ARG A 445
ASN A 398
THR A 156
 None
 0.84A 2q63A-3vsvA:
undetectable		 2q63A-3vsvA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2x EXODEOXYRIBONUCLEASE

(Methanothermobacter
thermautotrophicus) 		PF03372
(Exo_endo_phos) 		3 ARG A 194
ASN A 153
THR A 204
 None
 0.88A 2q63A-3w2xA:
undetectable		 2q63A-3w2xA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ARG A 504
ASN A 493
THR A 535
 None
 0.86A 2q63A-3wkyA:
undetectable		 2q63A-3wkyA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A  86
ASN A 625
THR A 726
 None
 0.76A 2q63A-4aipA:
undetectable		 2q63A-4aipA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5m PUTATIVE
EXODEOXYRIBONUCLEASE

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		3 ARG A 193
ASN A 151
THR A 203
 None
 0.82A 2q63A-4b5mA:
undetectable		 2q63A-4b5mA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		3 ARG A 327
ASN A 347
THR A 395
 None
None
EDO  A1590 (-4.9A)
 0.86A 2q63A-4c22A:
undetectable		 2q63A-4c22A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN

(Synechocystis
sp. PCC 6803) 		PF00502
(Phycobilisome) 		3 ARG A  17
ASN B  47
THR B  96
 None
 0.87A 2q63A-4f0tA:
undetectable		 2q63A-4f0tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE

(Nitrosomonas
europaea) 		PF13447
(Multi-haem_cyto) 		3 ARG A 223
ASN A 412
THR A 425
 None
 0.83A 2q63A-4fasA:
undetectable		 2q63A-4fasA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		3 ARG A 120
ASN A 269
THR A 312
 0T3  A 602 (-3.9A)
None
None
 0.89A 2q63A-4fdhA:
undetectable		 2q63A-4fdhA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 ARG A 122
ASN A 405
THR A 410
 None
 0.71A 2q63A-4grhA:
undetectable		 2q63A-4grhA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ARG A 802
ASN A 658
THR A 655
 None
 0.89A 2q63A-4iigA:
undetectable		 2q63A-4iigA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		3 ARG A 177
ASN A 264
THR A 289
 None
 0.83A 2q63A-4ixoA:
undetectable		 2q63A-4ixoA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 475
ASN A 498
THR A 511
 None
 0.87A 2q63A-4l7tA:
undetectable		 2q63A-4l7tA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu4 PUTATIVE CELL
FILAMENTATION
PROTEIN

(Bartonella
quintana) 		PF02661
(Fic) 		3 ARG A 180
ASN A 134
THR A 205
 None
 0.78A 2q63A-4lu4A:
undetectable		 2q63A-4lu4A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ

(Pseudomonas
putida) 		PF16822
(ALGX) 		3 ARG A 182
ASN A 255
THR A 194
 None
 0.83A 2q63A-4o8vA:
undetectable		 2q63A-4o8vA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		3 ARG A 447
ASN A 419
THR A 457
 None
 0.79A 2q63A-4oe1A:
undetectable		 2q63A-4oe1A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oou BETA-1,4-MANNANASE

(Cryptopygus
antarcticus) 		no annotation 3 ARG B 298
ASN B 289
THR B 249
 None
 0.82A 2q63A-4oouB:
undetectable		 2q63A-4oouB:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p29 LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		3 ARG A 136
ASN A  33
THR A  64
 None
 0.64A 2q63A-4p29A:
undetectable		 2q63A-4p29A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		3 ARG A 597
ASN A 517
THR A 593
 None
 0.81A 2q63A-4pbxA:
undetectable		 2q63A-4pbxA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase) 		3 ARG B 199
ASN B 125
THR A 150
 None
 0.86A 2q63A-4pelB:
undetectable		 2q63A-4pelB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyh PHOSPHOGLUCAN
PHOSPHATASE DSP4,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00782
(DSPc)
PF16561
(AMPK1_CBM) 		3 ARG A 364
ASN A 243
THR A 211
 None
 0.84A 2q63A-4pyhA:
undetectable		 2q63A-4pyhA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE

(Brucella
abortus) 		PF01370
(Epimerase) 		3 ARG A 233
ASN A 172
THR A 255
 None
 0.65A 2q63A-4twrA:
undetectable		 2q63A-4twrA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v03 SITE-DETERMINING
PROTEIN

(Aquifex
aeolicus) 		PF01656
(CbiA) 		3 ARG A 175
ASN A  45
THR A 214
 ADP  A 303 (-3.5A)
None
ADP  A 303 (-3.7A)
 0.82A 2q63A-4v03A:
undetectable		 2q63A-4v03A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		3 ARG A1296
ASN A1405
THR A1477
 None
 0.61A 2q63A-4w4tA:
undetectable		 2q63A-4w4tA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		3 ARG A 136
ASN A 119
THR A 219
 None
 0.61A 2q63A-4wgkA:
undetectable		 2q63A-4wgkA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6k ANHYDROSIALIDASE

([Ruminococcus]
gnavus) 		PF13088
(BNR_2) 		3 ARG A 637
ASN A 707
THR A 280
 3XR  A 802 (-3.0A)
None
None
 0.72A 2q63A-4x6kA:
undetectable		 2q63A-4x6kA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		3 ARG A 619
ASN A 683
THR A 268
 NHE  A 702 (-2.9A)
None
None
 0.73A 2q63A-4xhbA:
undetectable		 2q63A-4xhbA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhm THIOREDOXIN (TRX-3)

(Archaeoglobus
fulgidus) 		PF00085
(Thioredoxin) 		3 ARG A  96
ASN A  49
THR A  43
 None
 0.84A 2q63A-4xhmA:
undetectable		 2q63A-4xhmA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7i MYOTUBULARIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF06602
(Myotub-related) 		3 ARG A 183
ASN A 275
THR A 241
 None
PO4  A 601 (-4.5A)
None
 0.65A 2q63A-4y7iA:
undetectable		 2q63A-4y7iA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		3 ARG A  84
ASN A 189
THR A  78
 None
 0.88A 2q63A-4ynnA:
undetectable		 2q63A-4ynnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yw5 NEURAMINIDASE C

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		3 ARG A 662
ASN A 725
THR A 313
 G39  A 801 (-2.9A)
None
None
 0.83A 2q63A-4yw5A:
undetectable		 2q63A-4yw5A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrm UDP-GLUCOSE
4-EPIMERASE

(Thermotoga
maritima) 		PF01370
(Epimerase) 		3 ARG A 220
ASN A 172
THR A 238
 None
None
GOL  A 402 ( 4.1A)
 0.89A 2q63A-4zrmA:
undetectable		 2q63A-4zrmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		3 ARG A 505
ASN A 405
THR A 370
 None
None
PEG  A1563 (-4.0A)
 0.79A 2q63A-5a4jA:
undetectable		 2q63A-5a4jA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		3 ARG A  96
ASN A 346
THR A  71
 CA  A 401 (-4.7A)
None
None
 0.84A 2q63A-5az0A:
undetectable		 2q63A-5az0A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		3 ARG A 158
ASN A 193
THR A 202
 None
 0.74A 2q63A-5cdhA:
undetectable		 2q63A-5cdhA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		3 ARG A 172
ASN A 147
THR A 404
 None
 0.87A 2q63A-5cdiA:
undetectable		 2q63A-5cdiA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwe CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		3 ARG A 275
ASN A 240
THR A 248
 None
 0.83A 2q63A-5cweA:
undetectable		 2q63A-5cweA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx8 LIPOPROTEIN RAGB

(Porphyromonas
gingivalis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 212
ASN A 144
THR A 127
 None
 0.67A 2q63A-5cx8A:
undetectable		 2q63A-5cx8A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 ARG A1155
ASN A1049
THR A1178
 5RS  A1203 (-4.8A)
None
None
 0.85A 2q63A-5eqqA:
undetectable		 2q63A-5eqqA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp2 FERRIC ENTEROBACTIN
RECEPTOR PIRA

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 674
ASN A 679
THR A 627
 None
 0.82A 2q63A-5fp2A:
undetectable		 2q63A-5fp2A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		3 ARG A  36
ASN A 354
THR A 361
 None
None
A  C   2 ( 3.7A)
 0.84A 2q63A-5habA:
undetectable		 2q63A-5habA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijj SPX DOMAIN

(Chaetomium
thermophilum) 		PF03105
(SPX) 		3 ARG A 142
ASN A  54
THR A 127
 ACT  A 503 (-3.9A)
EDO  A 501 (-3.2A)
None
 0.86A 2q63A-5ijjA:
undetectable		 2q63A-5ijjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikn DNA PRIMASE/HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C)
PF13155
(Toprim_2) 		3 ARG D 124
ASN D  70
THR D 133
 None
 0.78A 2q63A-5iknD:
undetectable		 2q63A-5iknD:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 3 ARG A  84
ASN A 262
THR A 127
 None
None
GB  A 401 (-3.7A)
 0.79A 2q63A-5lq8A:
undetectable		 2q63A-5lq8A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
26S PROTEASOME
REGULATORY SUBUNIT
RPN8

(Saccharomyces
cerevisiae) 		PF01398
(JAB)
PF01399
(PCI)
PF08375
(Rpn3_C)
PF13012
(MitMem_reg) 		3 ARG S 480
ASN S 469
THR U 269
 None
 0.84A 2q63A-5mpdS:
undetectable		 2q63A-5mpdS:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		3 ARG A 670
ASN A 862
THR A1031
 None
 0.89A 2q63A-5mqmA:
undetectable		 2q63A-5mqmA:
6.83