SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q63_A_1UNA1001_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1am5 | PEPSIN (Gadus morhua) |
PF00026(Asp) | 6 | ASP A 215GLY A 217ASP A 303VAL A 222VAL A 291ILE A 300 | None | 1.23A | 2q63A-1am5A:7.9 | 2q63A-1am5A:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czi | CHYMOSIN (Bos taurus) |
PF00026(Asp) | 5 | ASP E 215GLY E 217VAL E 222GLY E 76ILE E 300 | None | 0.79A | 2q63A-1cziE:6.6 | 2q63A-1cziE:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d4e | FLAVOCYTOCHROME CFUMARATE REDUCTASE (Shewanellaoneidensis) |
PF00890(FAD_binding_2)PF14537(Cytochrom_c3_2) | 6 | LEU A 509GLY A 313ALA A 312ILE A 130VAL A 517ILE A 310 | NoneFAD A 600 (-3.5A)FAD A 600 (-3.4A)NoneNoneNone | 1.49A | 2q63A-1d4eA:undetectable | 2q63A-1d4eA:10.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fob | BETA-1,4-GALACTANASE (Aspergillusaculeatus) |
PF07745(Glyco_hydro_53) | 6 | GLY A 40ALA A 39ASP A 38VAL A 324ILE A 44ILE A 328 | None | 1.07A | 2q63A-1fobA:undetectable | 2q63A-1fobA:14.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpm | GMP SYNTHETASE (Escherichiacoli) |
PF00117(GATase)PF00958(GMP_synt_C)PF02540(NAD_synthase) | 5 | LEU A 393GLY A 237VAL A 384ILE A 337GLY A 335 | NonePOP A 526 (-3.4A)NoneNoneNone | 0.84A | 2q63A-1gpmA:undetectable | 2q63A-1gpmA:11.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ALA A 28ASP A 29VAL A 32GLY A 48VAL A 82ILE A 84 | A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 4.4A)A79 A 800 (-3.6A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.85A | 2q63A-1hvcA:14.1 | 2q63A-1hvcA:96.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ALA A 28ASP A 29VAL A 32GLY A 48PRO A 81VAL A 82ILE A 84 | A79 A 800 ( 4.0A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 ( 4.3A)A79 A 800 (-4.1A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.93A | 2q63A-1hvcA:14.1 | 2q63A-1hvcA:96.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 12 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 ( 3.8A)A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 4.4A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-4.5A)A79 A 800 (-3.6A) | 0.44A | 2q63A-1hvcA:14.1 | 2q63A-1hvcA:96.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 12 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81VAL A 82ILE A 84 | A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 ( 4.3A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-4.5A)A79 A 800 (-3.8A) | 0.43A | 2q63A-1hvcA:14.1 | 2q63A-1hvcA:96.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ig8 | HEXOKINASE PII (Saccharomycescerevisiae) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 5 | LEU A 41GLY A 399ALA A 401ILE A 453ILE A 438 | None | 0.87A | 2q63A-1ig8A:undetectable | 2q63A-1ig8A:12.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0h | NEOPULLULANASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16657(Malt_amylase_C) | 6 | ASP A 459GLY A 458VAL A 439ILE A 436VAL A 431ILE A 428 | None | 1.43A | 2q63A-1j0hA:undetectable | 2q63A-1j0hA:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kng | THIOL:DISULFIDEINTERCHANGE PROTEINCYCY (Bradyrhizobiumjaponicum) |
PF08534(Redoxin) | 5 | LEU A 57ASP A 142GLY A 145GLY A 152ILE A 116 | None | 0.87A | 2q63A-1kngA:undetectable | 2q63A-1kngA:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l8w | VLSE1 (Borreliellaburgdorferi) |
PF00921(Lipoprotein_2) | 5 | GLY A 221ALA A 222ASP A 277GLY A 197ILE A 284 | None | 0.86A | 2q63A-1l8wA:undetectable | 2q63A-1l8wA:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1llu | ALCOHOLDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 42ILE A 64GLY A 119VAL A 36ILE A 38 | None | 0.80A | 2q63A-1lluA:undetectable | 2q63A-1lluA:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lxy | ARGININE DEIMINASE (Mycoplasmaarginini) |
PF02274(Amidinotransf) | 6 | LEU A 65GLY A 18ILE A 17PRO A 402VAL A 23ILE A 70 | None | 1.29A | 2q63A-1lxyA:undetectable | 2q63A-1lxyA:13.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5w | AMINE OXIDASE[FLAVIN-CONTAINING]A (Rattusnorvegicus) |
PF01593(Amino_oxidase) | 5 | LEU A 233ALA A 29VAL A 238GLY A 22ILE A 23 | NoneNoneNoneFAD A 652 (-3.4A)FAD A 652 (-4.8A) | 0.89A | 2q63A-1o5wA:undetectable | 2q63A-1o5wA:10.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1orq | POTASSIUM CHANNEL (Aeropyrumpernix) |
PF00520(Ion_trans) | 6 | LEU C 218VAL C 39GLY C 209ILE C 168VAL C 44ILE C 40 | None | 1.47A | 2q63A-1orqC:undetectable | 2q63A-1orqC:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p4a | PUR OPERON REPRESSOR (Bacillussubtilis) |
PF00156(Pribosyltran)PF09182(PuR_N) | 6 | LEU A 152GLY A 228ALA A 227PRO A 155VAL A 154ILE A 131 | None | 1.42A | 2q63A-1p4aA:undetectable | 2q63A-1p4aA:16.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29VAL A 32PRO A 81ILE A 84 | None | 0.77A | 2q63A-1q9pA:10.3 | 2q63A-1q9pA:91.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6v | SUBTILISIN-LIKESERINE PROTEASE (Fervidobacteriumpennivorans) |
PF00082(Peptidase_S8) | 6 | LEU A 43ASP A 255GLY A 253GLY A 260ILE A 261VAL A 72 | None | 1.39A | 2q63A-1r6vA:undetectable | 2q63A-1r6vA:9.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s2t | PHOSPHOENOLPYRUVATEPHOSPHOMUTASE (Mytilus edulis) |
PF13714(PEP_mutase) | 5 | LEU A 71ALA A 32GLY A 42ILE A 23VAL A 108 | None | 0.85A | 2q63A-1s2tA:undetectable | 2q63A-1s2tA:19.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29GLY A 48PRO A 81ILE A 84 | None | 0.86A | 2q63A-1sivA:18.5 | 2q63A-1sivA:48.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 9 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.48A | 2q63A-1sivA:18.5 | 2q63A-1sivA:48.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1suu | DNA GYRASE SUBUNIT A (Borreliellaburgdorferi) |
PF03989(DNA_gyraseA_C) | 6 | GLY A 780ALA A 779VAL A 805GLY A 722ILE A 792ILE A 765 | None | 1.37A | 2q63A-1suuA:undetectable | 2q63A-1suuA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tlg | POLYANDROCARPALECTIN (Polyandrocarpamisakiensis) |
PF00059(Lectin_C) | 5 | LEU A 81GLY A 56ALA A 57ASP A 58GLY A 72 | None | 0.86A | 2q63A-1tlgA:undetectable | 2q63A-1tlgA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to3 | PUTATIVE ALDOLASEYIHT (Salmonellaenterica) |
PF01791(DeoC) | 6 | LEU A 184GLY A 188ALA A 189ASP A 190VAL A 127ILE A 158 | None | 0.84A | 2q63A-1to3A:undetectable | 2q63A-1to3A:12.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uag | UDP-N-ACETYLMURAMOYL-L-ALANINE/:D-GLUTAMATE LIGASE (Escherichiacoli) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 6 | LEU A 67GLY A 93ALA A 70GLY A 17PRO A 31VAL A 8 | None | 1.19A | 2q63A-1uagA:undetectable | 2q63A-1uagA:13.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usy | ATPPHOSPHORIBOSYLTRANSFERASE REGULATORYSUBUNIT (Thermotogamaritima) |
PF13393(tRNA-synt_His) | 5 | ALA C 251VAL C 114ILE C 238VAL C 109ILE C 113 | None | 0.57A | 2q63A-1usyC:undetectable | 2q63A-1usyC:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhc | PUTATIVE KHG/KDPGALDOLASE (Haemophilusinfluenzae) |
PF01081(Aldolase) | 5 | LEU A 82GLY A 87ALA A 88ASP A 89ILE A 29 | None | 0.89A | 2q63A-1vhcA:undetectable | 2q63A-1vhcA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vj0 | ALCOHOLDEHYDROGENASE,ZINC-CONTAINING (Thermotogamaritima) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 223GLY A 228ALA A 229ASP A 230ILE A 202 | None | 0.86A | 2q63A-1vj0A:undetectable | 2q63A-1vj0A:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkn | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Thermotogamaritima) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | LEU A 70VAL A 139ILE A 120VAL A 89ILE A 91 | None | 0.81A | 2q63A-1vknA:undetectable | 2q63A-1vknA:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vrg | PROPIONYL-COACARBOXYLASE, BETASUBUNIT (Thermotogamaritima) |
PF01039(Carboxyl_trans) | 6 | GLY A 416ALA A 417ASP A 418ILE A 395ILE A 346VAL A 360 | None | 1.32A | 2q63A-1vrgA:undetectable | 2q63A-1vrgA:12.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wac | P2 PROTEIN (Pseudomonasvirus phi6) |
PF00680(RdRP_1) | 6 | LEU A 252GLY A 35ALA A 36PRO A 261VAL A 260ILE A 258 | None | 1.28A | 2q63A-1wacA:undetectable | 2q63A-1wacA:9.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wsv | AMINOMETHYLTRANSFERASE (Homo sapiens) |
PF01571(GCV_T)PF08669(GCV_T_C) | 5 | LEU A 152VAL A 192GLY A 166VAL A 207ILE A 205 | LEU A 152 ( 0.6A)VAL A 192 ( 0.6A)GLY A 166 ( 0.0A)VAL A 207 ( 0.6A)ILE A 205 ( 0.4A) | 0.85A | 2q63A-1wsvA:undetectable | 2q63A-1wsvA:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x0u | HYPOTHETICALMETHYLMALONYL-COADECARBOXYLASE ALPHASUBUNIT (Sulfurisphaeratokodaii) |
PF01039(Carboxyl_trans) | 5 | GLY A 424ALA A 425ASP A 426ILE A 354VAL A 368 | None | 0.83A | 2q63A-1x0uA:undetectable | 2q63A-1x0uA:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xa0 | PUTATIVE NADPHDEPENDENTOXIDOREDUCTASES (Geobacillusstearothermophilus) |
PF00107(ADH_zinc_N) | 5 | GLY A 131ALA A 130ILE A 66ILE A 87VAL A 324 | NoneSO4 A 329 ( 4.2A)NoneNoneNone | 0.82A | 2q63A-1xa0A:undetectable | 2q63A-1xa0A:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xfj | CONSERVEDHYPOTHETICAL PROTEIN (Caulobactervibrioides) |
PF02578(Cu-oxidase_4) | 5 | ALA A 128VAL A 146ILE A 159GLY A 161VAL A 141 | None | 0.87A | 2q63A-1xfjA:undetectable | 2q63A-1xfjA:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y2i | HYPOTHETICAL PROTEINS0862 (Shigellaflexneri) |
PF01906(YbjQ_1) | 6 | GLY A 73ALA A 74ASP A 75VAL A 78ILE A 14VAL A 20 | None | 1.47A | 2q63A-1y2iA:undetectable | 2q63A-1y2iA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zo1 | TRANSLATIONINITIATION FACTOR 1 (Escherichiacoli) |
PF01176(eIF-1a) | 5 | LEU W 26GLY W 65ALA W 34VAL W 13ILE W 47 | None | 0.89A | 2q63A-1zo1W:undetectable | 2q63A-1zo1W:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aqw | PUTATIVEOROTIDINE-MONOPHOSPHATE-DECARBOXYLASE (Plasmodiumyoelii) |
PF00215(OMPdecase) | 6 | ALA A 221VAL A 244ILE A 264GLY A 241ILE A 240ILE A 195 | None | 1.42A | 2q63A-2aqwA:undetectable | 2q63A-2aqwA:14.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3x | IRON-RESPONSIVEELEMENT BINDINGPROTEIN 1 (Homo sapiens) |
PF00330(Aconitase)PF00694(Aconitase_C) | 6 | LEU A 669GLY A 672ALA A 770VAL A 795GLY A 775PRO A 787 | None | 1.03A | 2q63A-2b3xA:undetectable | 2q63A-2b3xA:6.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb0 | IMIDAZOLONEPROPIONASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 6 | LEU A 374GLY A 409VAL A 48ILE A 5ILE A 65ILE A 47 | None | 1.11A | 2q63A-2bb0A:undetectable | 2q63A-2bb0A:13.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bih | NITRATE REDUCTASE[NADPH] (Ogataea angusta) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 5 | LEU A 256GLY A 178ALA A 180VAL A 107ILE A 109 | None | 0.87A | 2q63A-2bihA:undetectable | 2q63A-2bihA:11.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bii | NITRATE REDUCTASE[NADPH] (Ogataea angusta) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 5 | LEU A 256GLY A 178ALA A 180VAL A 107ILE A 109 | None | 0.81A | 2q63A-2biiA:undetectable | 2q63A-2biiA:11.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c4n | PROTEIN NAGD (Escherichiacoli) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 6 | LEU A 41GLY A 210VAL A 6ILE A 3VAL A 39ILE A 7 | None | 1.47A | 2q63A-2c4nA:undetectable | 2q63A-2c4nA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cun | PHOSPHOGLYCERATEKINASE (Pyrococcushorikoshii) |
PF00162(PGK) | 5 | LEU A 316ILE A 376GLY A 357VAL A 343ILE A 347 | None | 0.84A | 2q63A-2cunA:undetectable | 2q63A-2cunA:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1q | LUCIFERIN4-MONOOXYGENASE (Luciolacruciata) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | LEU A 514GLY A 470ALA A 469ASP A 468VAL A 504 | None | 0.87A | 2q63A-2d1qA:undetectable | 2q63A-2d1qA:12.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 9 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29VAL A 32GLY A 54PRO A 86ILE A 89 | NoneLP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)NoneLP1 A 201 (-3.6A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.92A | 2q63A-2fmbA:15.0 | 2q63A-2fmbA:29.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 11 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29VAL A 32ILE A 53GLY A 55PRO A 86VAL A 87ILE A 89 | NoneLP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)NoneLP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 ( 4.9A)LP1 A 201 (-4.2A) | 0.48A | 2q63A-2fmbA:15.0 | 2q63A-2fmbA:29.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g1s | RENIN (Homo sapiens) |
PF00026(Asp) | 5 | LEU A 219ASP A 221GLY A 223ALA A 224PRO A 301 | None4IG A 885 (-2.6A)4IG A 885 (-3.9A)4IG A 885 ( 4.7A)None | 0.76A | 2q63A-2g1sA:8.2 | 2q63A-2g1sA:12.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3n | ALPHA-GLUCOSIDASE (Sulfolobussolfataricus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 5 | GLY A 115ILE A 102GLY A 66ILE A 65PRO A 528 | None | 0.75A | 2q63A-2g3nA:undetectable | 2q63A-2g3nA:8.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gd2 | PROBABLEALPHA-METHYLACYL-COARACEMASE MCR (Mycobacteriumtuberculosis) |
PF02515(CoA_transf_3) | 6 | LEU A 73GLY A 66ALA A 59ASP A 60VAL A 11ILE A 36 | NoneNoneNoneCAA A1751 ( 4.7A)NoneNone | 1.39A | 2q63A-2gd2A:undetectable | 2q63A-2gd2A:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hk7 | SHIKIMATEDEHYDROGENASE (Aquifexaeolicus) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 6 | GLY A 146ALA A 147VAL A 183ILE A 118VAL A 128ILE A 126 | None | 1.06A | 2q63A-2hk7A:undetectable | 2q63A-2hk7A:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hmf | PROBABLEASPARTOKINASE (Methanocaldococcusjannaschii) |
PF00696(AA_kinase)PF01842(ACT)PF13840(ACT_7) | 6 | GLY A 139ALA A 140ASP A 143ILE A 97VAL A 12ILE A 18 | None | 1.42A | 2q63A-2hmfA:undetectable | 2q63A-2hmfA:12.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | GLY A 190ALA A 189GLY A 183ILE A 180PRO A 296 | NoneNonePLP A 400 (-3.4A)PLP A 400 (-4.9A)PLP A 400 (-4.0A) | 0.78A | 2q63A-2isqA:undetectable | 2q63A-2isqA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iss | PYRIDOXALBIOSYNTHESIS LYASEPDXS (Thermotogamaritima) |
PF01680(SOR_SNZ) | 5 | LEU A 224GLY A 229ALA A 230ASP A 231VAL A 158 | None | 0.84A | 2q63A-2issA:undetectable | 2q63A-2issA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nr7 | SECRETION ACTIVATORPROTEIN, PUTATIVE (Porphyromonasgingivalis) |
PF05838(Glyco_hydro_108)PF09374(PG_binding_3) | 5 | LEU A 134GLY A 102ILE A 103VAL A 87ILE A 138 | None | 0.83A | 2q63A-2nr7A:undetectable | 2q63A-2nr7A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p50 | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Escherichiacoli) |
PF01979(Amidohydro_1) | 6 | LEU A 184ALA A 163ASP A 164GLY A 127VAL A 191ILE A 189 | None | 1.17A | 2q63A-2p50A:undetectable | 2q63A-2p50A:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph3 | 3-OXOACYL-[ACYLCARRIER PROTEIN]REDUCTASE (Thermusthermophilus) |
PF13561(adh_short_C2) | 6 | LEU A 28GLY A 14ALA A 9VAL A 56VAL A 54ILE A 30 | None | 1.06A | 2q63A-2ph3A:undetectable | 2q63A-2ph3A:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q0l | THIOREDOXINREDUCTASE (Helicobacterpylori) |
PF07992(Pyr_redox_2) | 5 | ALA A 5VAL A 84ILE A 108GLY A 8ILE A 93 | NoneNoneNoneFAD A 400 (-3.2A)None | 0.87A | 2q63A-2q0lA:undetectable | 2q63A-2q0lA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjg | PUTATIVE ALDOLASEMJ0400 (Methanocaldococcusjannaschii) |
PF01791(DeoC) | 5 | LEU A 174GLY A 179ALA A 180ASP A 181ILE A 149 | None | 0.75A | 2q63A-2qjgA:undetectable | 2q63A-2qjgA:16.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qma | DIAMINOBUTYRATE-PYRUVATE TRANSAMINASEANDL-2,4-DIAMINOBUTYRATE DECARBOXYLASE (Vibrioparahaemolyticus) |
PF00282(Pyridoxal_deC) | 5 | GLY A 728ALA A 727ASP A 755VAL A 774ILE A 780 | None | 0.87A | 2q63A-2qmaA:undetectable | 2q63A-2qmaA:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ri6 | 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE (Paraburkholderiaxenovorans) |
PF12697(Abhydrolase_6) | 6 | LEU A 283GLY A 63ALA A 62GLY A 57VAL A 279ILE A 280 | None | 0.97A | 2q63A-2ri6A:undetectable | 2q63A-2ri6A:16.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 28ASP A 29GLY A 48PRO A 81ILE A 84 | AB1 A 501 (-3.5A)AB1 A 501 ( 3.3A)AB1 A 501 (-4.2A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.82A | 2q63A-2rkfA:21.1 | 2q63A-2rkfA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | LEU A 23ASP A 25GLY A 27ALA A 28ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | NoneAB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.5A)AB1 A 501 ( 3.3A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.49A | 2q63A-2rkfA:21.1 | 2q63A-2rkfA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rsp | RSV PROTEASE (Rous sarcomavirus) |
PF00077(RVP) | 6 | LEU A 35ASP A 37GLY A 39ALA A 40ASP A 41ILE A 108 | None | 0.23A | 2q63A-2rspA:12.8 | 2q63A-2rspA:32.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v6b | L-LACTATEDEHYDROGENASE (Deinococcusradiodurans) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 6 | LEU A 136GLY A 251ALA A 36VAL A 26VAL A 93ILE A 95 | None | 1.21A | 2q63A-2v6bA:undetectable | 2q63A-2v6bA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vvg | KINESIN-2 (Giardiaintestinalis) |
PF00225(Kinesin) | 5 | LEU A 307ASP A 241ILE A 117GLY A 115ILE A 93 | None MG A1352 ( 4.1A)NoneNoneNone | 0.82A | 2q63A-2vvgA:undetectable | 2q63A-2vvgA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wqd | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Staphylococcusaureus) |
PF00391(PEP-utilizers)PF02896(PEP-utilizers_C)PF05524(PEP-utilisers_N) | 6 | VAL A 229ILE A 220GLY A 180ILE A 201VAL A 205ILE A 204 | None | 1.48A | 2q63A-2wqdA:undetectable | 2q63A-2wqdA:10.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xt0 | HALOALKANEDEHALOGENASE (Plesiocystispacifica) |
PF00561(Abhydrolase_1) | 6 | LEU A 252ASP A 123GLY A 54ILE A 183PRO A 250VAL A 251 | None | 1.49A | 2q63A-2xt0A:undetectable | 2q63A-2xt0A:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yb6 | UBIQUITIN-CONJUGATING ENZYME E2 B (Homo sapiens) |
PF00179(UQ_con) | 5 | GLY A 26ALA A 38VAL A 70ILE A 109ILE A 57 | None | 0.85A | 2q63A-2yb6A:undetectable | 2q63A-2yb6A:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5x | AMINE OXIDASE[FLAVIN-CONTAINING]A (Homo sapiens) |
PF01593(Amino_oxidase) | 5 | LEU A 233ALA A 29VAL A 238GLY A 22ILE A 23 | NoneNoneNoneFAD A 600 (-3.2A)FAD A 600 (-4.9A) | 0.85A | 2q63A-2z5xA:undetectable | 2q63A-2z5xA:12.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqc | COMPONENT A OFHEXAPRENYLDIPHOSPHATE SYNTHASE (Micrococcusluteus) |
no annotation | 6 | LEU A 95ASP A 27VAL A 48ILE A 31VAL A 43ILE A 47 | None | 1.48A | 2q63A-3aqcA:undetectable | 2q63A-3aqcA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqp | PROBABLE SECDFPROTEIN-EXPORTMEMBRANE PROTEIN (Thermusthermophilus) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 5 | GLY A 327ALA A 329GLY A 274ILE A 271VAL A 693 | None | 0.77A | 2q63A-3aqpA:undetectable | 2q63A-3aqpA:9.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b46 | AMINOTRANSFERASEBNA3 (Saccharomycescerevisiae) |
PF00155(Aminotran_1_2) | 5 | LEU A 264GLY A 260ALA A 253ILE A 108VAL A 283 | None | 0.84A | 2q63A-3b46A:undetectable | 2q63A-3b46A:12.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b8b | CYSQ, SULFITESYNTHESIS PATHWAYPROTEIN (Bacteroidesthetaiotaomicron) |
PF00459(Inositol_P) | 6 | ALA A 6ASP A 5VAL A 112GLY A 11ILE A 14ILE A 100 | None | 1.35A | 2q63A-3b8bA:undetectable | 2q63A-3b8bA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c4n | UNCHARACTERIZEDPROTEIN DR_0571 (Deinococcusradiodurans) |
PF01266(DAO) | 5 | LEU A 370GLY A 200VAL A 40VAL A 230ILE A 228 | None | 0.87A | 2q63A-3c4nA:undetectable | 2q63A-3c4nA:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d79 | PUTATIVEUNCHARACTERIZEDPROTEIN PH0734 (Pyrococcushorikoshii) |
PF01472(PUA)PF09183(DUF1947) | 6 | LEU A 101GLY A 95ALA A 96VAL A 106ILE A 111ILE A 100 | None | 1.14A | 2q63A-3d79A:undetectable | 2q63A-3d79A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecd | SERINEHYDROXYMETHYLTRANSFERASE 2 (Burkholderiapseudomallei) |
PF00464(SHMT) | 6 | LEU A 295GLY A 216ALA A 215PRO A 370VAL A 294ILE A 291 | None | 1.26A | 2q63A-3ecdA:undetectable | 2q63A-3ecdA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 6 | LEU A 360GLY A 464ALA A 465ASP A 485VAL A 542VAL A 456 | None | 1.42A | 2q63A-3ecqA:undetectable | 2q63A-3ecqA:5.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 6 | LEU A 360GLY A 464ALA A 465VAL A 542ILE A 484VAL A 456 | None | 1.14A | 2q63A-3ecqA:undetectable | 2q63A-3ecqA:5.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3efb | PROBABLE SOR-OPERONREGULATOR (Shigellaflexneri) |
PF04198(Sugar-bind) | 6 | LEU A 57ASP A 27GLY A 230ILE A 231VAL A 63ILE A 157 | None | 1.45A | 2q63A-3efbA:undetectable | 2q63A-3efbA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbs | OXIDOREDUCTASE (Agrobacteriumfabrum) |
PF07992(Pyr_redox_2) | 5 | GLY A 284ALA A 17ILE A 66GLY A 22ILE A 7 | None | 0.87A | 2q63A-3fbsA:undetectable | 2q63A-3fbsA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7r | PUTATIVETRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N) | 5 | ALA A 167VAL A 99GLY A 186VAL A 94ILE A 98 | NoneNoneNoneNoneEDO A 960 ( 4.8A) | 0.87A | 2q63A-3g7rA:undetectable | 2q63A-3g7rA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7r | PUTATIVETRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N) | 5 | GLY A 166ALA A 167VAL A 99GLY A 186ILE A 98 | NoneNoneNoneNoneEDO A 960 ( 4.8A) | 0.86A | 2q63A-3g7rA:undetectable | 2q63A-3g7rA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gf7 | GLUTACONYL-COADECARBOXYLASESUBUNIT A ([Clostridium]symbiosum) |
PF01039(Carboxyl_trans) | 5 | LEU A 148GLY A 191ALA A 213GLY A 256ILE A 189 | None | 0.89A | 2q63A-3gf7A:undetectable | 2q63A-3gf7A:10.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gh8 | IODOTYROSINEDEHALOGENASE 1 (Mus musculus) |
PF00881(Nitroreductase) | 5 | LEU A 256GLY A 218ILE A 116GLY A 120ILE A 190 | None | 0.82A | 2q63A-3gh8A:undetectable | 2q63A-3gh8A:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gmi | UPF0348 PROTEINMJ0951 (Methanocaldococcusjannaschii) |
PF05636(HIGH_NTase1)PF16581(HIGH_NTase1_ass) | 5 | LEU A 62GLY A 111ALA A 112ASP A 113GLY A 73 | None | 0.87A | 2q63A-3gmiA:undetectable | 2q63A-3gmiA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gve | YFKN PROTEIN (Bacillussubtilis) |
PF00149(Metallophos) | 5 | GLY A 121ALA A 122ASP A 123ILE A 89ILE A 126 | None | 0.80A | 2q63A-3gveA:undetectable | 2q63A-3gveA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdy | UDP-GALACTOPYRANOSEMUTASE (Deinococcusradiodurans) |
PF03275(GLF)PF13450(NAD_binding_8) | 5 | GLY A 38ALA A 37VAL A 237VAL A 55ILE A 57 | FAD A 450 (-3.3A)NoneNoneNoneNone | 0.88A | 2q63A-3hdyA:undetectable | 2q63A-3hdyA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hh1 | TETRAPYRROLEMETHYLASE FAMILYPROTEIN (Chlorobaculumtepidum) |
PF00590(TP_methylase) | 5 | LEU A 79GLY A 111ALA A 110VAL A 75ILE A 76 | None | 0.85A | 2q63A-3hh1A:undetectable | 2q63A-3hh1A:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5g | MYOSIN HEAVY CHAINISOFORM A (Doryteuthispealeii) |
PF00063(Myosin_head)PF00612(IQ)PF02736(Myosin_N) | 6 | GLY A 264ALA A 265ASP A 266GLY A 460ILE A 459ILE A 224 | None | 1.03A | 2q63A-3i5gA:undetectable | 2q63A-3i5gA:8.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iay | DNA POLYMERASE DELTACATALYTIC SUBUNIT (Saccharomycescerevisiae) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 5 | ASP A 976GLY A 975ALA A 971ILE A 811GLY A 598 | None | 0.84A | 2q63A-3iayA:undetectable | 2q63A-3iayA:7.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ifr | CARBOHYDRATE KINASE,FGGY (Rhodospirillumrubrum) |
PF00370(FGGY_N)PF02782(FGGY_C) | 6 | LEU A 435GLY A 440ALA A 442ILE A 80VAL A 33ILE A 22 | None | 1.46A | 2q63A-3ifrA:undetectable | 2q63A-3ifrA:10.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j7a | 40S RIBOSOMALPROTEIN ES6 (Plasmodiumfalciparum) |
PF01092(Ribosomal_S6e) | 5 | LEU H 111GLY H 55ILE H 101GLY H 103ILE H 52 | None G A 160 ( 3.9A)NoneNoneNone | 0.87A | 2q63A-3j7aH:undetectable | 2q63A-3j7aH:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jv7 | ADH-A (Rhodococcusruber) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 211GLY A 216ALA A 217ASP A 218ILE A 190 | None | 0.69A | 2q63A-3jv7A:undetectable | 2q63A-3jv7A:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jzl | PUTATIVECYSTATHIONINEBETA-LYASE INVOLVEDIN ALUMINUMRESISTANCE (Listeriamonocytogenes) |
PF06838(Met_gamma_lyase) | 5 | LEU A 114GLY A 95ILE A 96VAL A 118ILE A 117 | None | 0.87A | 2q63A-3jzlA:undetectable | 2q63A-3jzlA:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kf3 | INVERTASE (Schwanniomycesoccidentalis) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 5 | ASP A 287GLY A 289ASP A 291ILE A 485PRO A 355 | NoneNoneNoneNoneNAG A5001 ( 4.9A) | 0.88A | 2q63A-3kf3A:undetectable | 2q63A-3kf3A:12.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kiz | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Cytophagahutchinsonii) |
PF02769(AIRS_C) | 5 | GLY A 59ASP A 161ILE A 108VAL A 77ILE A 81 | EDO A 398 ( 3.8A)NoneACT A 394 ( 4.6A)NoneNone | 0.83A | 2q63A-3kizA:undetectable | 2q63A-3kizA:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lkb | PROBABLEBRANCHED-CHAIN AMINOACID ABCTRANSPORTER, AMINOACID BINDING PROTEIN (Thermusthermophilus) |
PF13458(Peripla_BP_6) | 5 | ALA A 167VAL A 146ILE A 137VAL A 177ILE A 174 | None | 0.86A | 2q63A-3lkbA:undetectable | 2q63A-3lkbA:14.75 |