SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q58_B_ZOLB2_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		7 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
 0.42A 2q58B-1rqjA:
26.5		 2q58B-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		6 ASP A 105
ASP A 111
GLN A 179
LYS A 202
THR A 203
LYS A 268
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
MG  A 909 ( 4.2A)
 1.23A 2q58B-1rqjA:
26.5		 2q58B-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 ASP A  82
ASP A  88
ARG A  93
GLN A 154
THR A 178
 None
 1.28A 2q58B-1rtrA:
24.3		 2q58B-1rtrA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		6 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
MG  A 341 ( 4.6A)
 1.09A 2q58B-2dh4A:
25.7		 2q58B-2dh4A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		7 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.77A 2q58B-2dh4A:
25.7		 2q58B-2dh4A:
26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		8 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
ASN A 254
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
RIS  A 400 ( 2.3A)
 0.47A 2q58B-2o1oA:
45.3		 2q58B-2o1oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		5 ASP A 115
ASP A 119
GLN A 184
LYS A 210
LYS A 273
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
MG  A 502 ( 4.5A)
 1.49A 2q58B-2o1oA:
45.3		 2q58B-2o1oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
 GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
 0.75A 2q58B-2q80A:
24.7		 2q58B-2q80A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
LYS A 212
 GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-2.8A)
 1.10A 2q58B-2q80A:
24.7		 2q58B-2q80A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.91A 2q58B-3aq0A:
25.3		 2q58B-3aq0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 1.00A 2q58B-3aqcB:
26.7		 2q58B-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 1.15A 2q58B-3aqcB:
26.7		 2q58B-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		5 ARG A 102
LYS A 179
THR A 180
GLN A 217
LYS A 244
 None
 1.03A 2q58B-3mzvA:
25.3		 2q58B-3mzvA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		6 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.63A 2q58B-3p41A:
23.1		 2q58B-3p41A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		7 ASP A  92
ASP A  98
ARG A 103
GLN A 163
LYS A 186
THR A 187
GLN A 225
 MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.6A)
DMA  A 501 (-3.1A)
DMA  A 500 (-3.4A)
DMA  A 501 ( 3.8A)
 0.50A 2q58B-3q1oA:
27.3		 2q58B-3q1oA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 ASP A 108
ASP A 112
ARG A 117
GLN A 191
LYS A 215
 MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 384 (-3.0A)
 0.87A 2q58B-3qqvA:
29.7		 2q58B-3qqvA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		6 ASP A 108
ASP A 112
ARG A 117
LYS A 215
THR A 216
GLN A 254
 MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 ( 4.0A)
DMA  A 383 (-3.2A)
 0.77A 2q58B-3qqvA:
29.7		 2q58B-3qqvA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 ASP A  77
LYS A 162
THR A 163
GLN A 197
LYS A 224
 None
 0.87A 2q58B-3tc1A:
24.3		 2q58B-3tc1A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		5 ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.72A 2q58B-3zouA:
23.0		 2q58B-3zouA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		7 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
 0.66A 2q58B-4e1eA:
36.8		 2q58B-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		5 ASP A  98
ASP A 102
GLN A 167
LYS A 207
LYS A 273
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
MG  A 403 ( 4.5A)
 1.27A 2q58B-4e1eA:
36.8		 2q58B-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.06A 2q58B-4fp4A:
18.0		 2q58B-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ASP A  90
LYS A 162
THR A 163
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
GER  A 301 ( 4.8A)
None
None
 1.21A 2q58B-4fp4A:
18.0		 2q58B-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 1.09A 2q58B-4gp1A:
26.9		 2q58B-4gp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		5 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.79A 2q58B-4jzxA:
37.1		 2q58B-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		6 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
 0.65A 2q58B-4jzxA:
37.1		 2q58B-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.90A 2q58B-4lfeA:
25.3		 2q58B-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		6 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.61A 2q58B-4lfeA:
25.3		 2q58B-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.66A 2q58B-4llsA:
25.2		 2q58B-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.86A 2q58B-4llsA:
25.2		 2q58B-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		7 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
 0.42A 2q58B-4p0vA:
36.3		 2q58B-4p0vA:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 ASP A 103
ASP A 107
GLN A 171
LYS A 200
LYS A 266
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
MG  A 405 ( 4.4A)
 1.38A 2q58B-4p0vA:
36.3		 2q58B-4p0vA:
29.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		7 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
 0.52A 2q58B-4rxeA:
36.2		 2q58B-4rxeA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
LYS B 278
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
MG  B1369 (-3.6A)
 1.12A 2q58B-5ahuB:
27.3		 2q58B-5ahuB:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		7 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
 0.74A 2q58B-5ahuB:
27.3		 2q58B-5ahuB:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 ASP A  82
ASP A  86
ARG A  91
LYS A 168
THR A 169
 None
None
PO4  A 501 ( 4.9A)
None
None
 1.20A 2q58B-5h9dA:
26.4		 2q58B-5h9dA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		6 ASP A 126
ASP A 130
ARG A 135
GLN A 195
LYS A 243
GLN A 284
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-3.3A)
04M  A 401 (-4.5A)
None
 0.89A 2q58B-5hn7A:
36.3		 2q58B-5hn7A:
32.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		5 ASP A 126
ASP A 130
ARG A 135
LYS A 243
LYS A 310
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-4.5A)
None
 1.40A 2q58B-5hn7A:
36.3		 2q58B-5hn7A:
32.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		6 ASP A 126
ASP A 130
ARG A 135
LYS A 243
THR A 244
GLN A 284
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-4.5A)
04M  A 401 ( 3.8A)
None
 0.70A 2q58B-5hn7A:
36.3		 2q58B-5hn7A:
32.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		5 ASP A  56
ASP A  60
ARG A  53
GLN A 166
ASN A 169
 MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
FPS  A 506 ( 3.1A)
FPS  A 507 (-3.9A)
MG  A 503 (-2.9A)
 1.02A 2q58B-5iysA:
8.3		 2q58B-5iysA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		5 ASP A  56
ASP A  60
GLN A 113
GLN A 166
ASN A 169
 MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
MG  A 503 (-2.9A)
 0.72A 2q58B-5iysA:
8.3		 2q58B-5iysA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 7 ASP A 147
ASP A 151
ARG A 156
GLN A 215
LYS A 244
THR A 245
GLN A 284
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-3.3A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.6A)
C6M  A 401 (-3.7A)
 0.49A 2q58B-6b07A:
36.2		 2q58B-6b07A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 ASP A 147
ASP A 151
GLN A 215
LYS A 244
LYS A 310
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-3.3A)
C6M  A 401 (-2.6A)
MG  A 402 ( 4.3A)
 1.33A 2q58B-6b07A:
36.2		 2q58B-6b07A:
13.41