SIMILAR PATTERNS OF AMINO ACIDS FOR 2Q0I_A_BEZA990

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		4 ASP A  56
GLU A  55
HIS A  53
SER A  94
 None
 0.99A 2q0iA-1bxcA:
undetectable		 2q0iA-1bxcA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqq TYPE 2 RHINOVIRUS 3C
PROTEASE

(Rhinovirus A) 		PF00548
(Peptidase_C3) 		4 GLU A  94
LEU A 175
SER A 121
LEU A 136
 None
 1.12A 2q0iA-1cqqA:
undetectable		 2q0iA-1cqqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		4 ASP A 301
LEU A 271
HIS A 257
LEU A 303
 ZN  A 401 ( 2.6A)
None
None
None
 0.96A 2q0iA-1eywA:
undetectable		 2q0iA-1eywA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		4 ASP A 272
ASP A 154
SER A 251
HIS A 248
 None
 0.88A 2q0iA-1f1uA:
undetectable		 2q0iA-1f1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 ASP A 272
ASP A 154
SER A 251
HIS A 248
 None
None
FEL  A 500 ( 4.3A)
FEL  A 500 ( 4.8A)
 0.84A 2q0iA-1f1xA:
undetectable		 2q0iA-1f1xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gaj HIGH-AFFINITY
BRANCHED CHAIN AMINO
ACID TRANSPORT
ATP-BINDING PROTEIN

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		4 ASP A 191
LEU A 188
HIS A 195
LEU A 143
 None
 1.03A 2q0iA-1gajA:
undetectable		 2q0iA-1gajA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ASP B 622
GLU B 624
HIS B 621
LEU B  43
 None
 1.05A 2q0iA-1gl9B:
undetectable		 2q0iA-1gl9B:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A  29
GLU A  31
HIS A  32
SER A  33
 None
 1.11A 2q0iA-1kcwA:
undetectable		 2q0iA-1kcwA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 ASP A  30
ASP A 156
GLU A  61
HIS A 158
 None
 0.90A 2q0iA-1lf9A:
undetectable		 2q0iA-1lf9A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqk PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN

(Pseudomonas
aeruginosa) 		PF00903
(Glyoxalase) 		4 ASP A 103
LEU A 109
HIS A 107
LEU A   8
 None
 1.05A 2q0iA-1lqkA:
undetectable		 2q0iA-1lqkA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		4 ASP A 151
LEU A  67
HIS A 302
LEU A 123
 ZN  A 401 (-2.6A)
None
ZN  A 401 (-3.4A)
None
 1.03A 2q0iA-1p9eA:
15.6		 2q0iA-1p9eA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		4 ASP A 200
ASP A 131
LEU A 123
SER A 206
 None
 0.96A 2q0iA-1toaA:
undetectable		 2q0iA-1toaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 ASP A 195
GLU A 202
HIS A 199
LEU A 286
 FE  A 400 (-2.2A)
None
FE  A 400 ( 3.3A)
None
 1.06A 2q0iA-1vljA:
undetectable		 2q0iA-1vljA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		4 ASP A 139
LEU A 169
HIS A 151
LEU A 185
 None
 1.05A 2q0iA-1wz8A:
undetectable		 2q0iA-1wz8A:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		4 ASP A 108
ASP A 191
HIS A 235
LEU A  16
 ZN  A 251 ( 2.7A)
ZN  A 251 ( 2.4A)
ZN  A 251 (-3.3A)
GOL  A 805 (-4.9A)
 0.87A 2q0iA-2a7mA:
13.7		 2q0iA-2a7mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0o UPLC1

(Homo sapiens) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		4 ASP E 443
LEU E 456
HIS E 468
HIS E 538
 None
 0.78A 2q0iA-2b0oE:
undetectable		 2q0iA-2b0oE:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e67 HYPOTHETICAL PROTEIN
TTHB029

(Thermus
thermophilus) 		PF04794
(YdjC) 		4 ASP A  20
ASP A 125
LEU A 152
HIS A  18
 MG  A 301 (-4.3A)
None
None
None
 0.95A 2q0iA-2e67A:
undetectable		 2q0iA-2e67A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e67 HYPOTHETICAL PROTEIN
TTHB029

(Thermus
thermophilus) 		PF04794
(YdjC) 		4 ASP A  21
LEU A  24
HIS A 127
SER A  65
 MG  A 301 (-2.6A)
None
MG  A 301 (-3.0A)
None
 0.90A 2q0iA-2e67A:
undetectable		 2q0iA-2e67A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6r BIFUNCTIONAL
COENZYME A SYNTHASE

(Mus musculus) 		PF01121
(CoaE) 		4 GLU A 190
LEU A  66
HIS A 189
LEU A 261
 None
 0.80A 2q0iA-2f6rA:
undetectable		 2q0iA-2f6rA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		4 ASP A 325
GLU A 270
HIS A 247
HIS A 131
 ZN  A 522 (-2.8A)
None
ZN  A 523 (-3.6A)
None
 1.08A 2q0iA-2ftwA:
undetectable		 2q0iA-2ftwA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu1 ZINC PEPTIDASE

(Vibrio cholerae) 		PF01551
(Peptidase_M23)
PF04225
(OapA) 		4 ASP A 236
GLU A 315
HIS A 232
LEU A  40
 ZN  A 362 (-2.1A)
None
ZN  A 362 (-3.2A)
None
 1.01A 2q0iA-2gu1A:
undetectable		 2q0iA-2gu1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzh LACCASE

(Trametes
ochracea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASP A 118
GLU A 460
SER A 113
LEU A  58
 None
 1.10A 2q0iA-2hzhA:
undetectable		 2q0iA-2hzhA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		5 ASP A 149
ASP A 101
GLU A 173
SER A 209
HIS A 238
 None
None
None
None
ZN  A 500 (-3.2A)
 1.49A 2q0iA-2imrA:
undetectable		 2q0iA-2imrA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		4 ASP A 141
SER A 116
LEU A 120
HIS A 117
 None
 1.10A 2q0iA-2j0wA:
undetectable		 2q0iA-2j0wA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120) 		PF00378
(ECH_1) 		4 ASP D 153
ASP D 141
LEU D 172
HIS D 144
 None
 1.11A 2q0iA-2j5gD:
undetectable		 2q0iA-2j5gD:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		4 ASP A1043
LEU A1050
SER A1072
LEU A 666
 None
 1.10A 2q0iA-2j7nA:
undetectable		 2q0iA-2j7nA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ASP A  87
ASP A 170
LEU A 202
HIS A 233
 FE  A 501 (-2.9A)
FE  A 501 ( 2.3A)
None
FE  A 501 (-3.2A)
 0.76A 2q0iA-2ohhA:
19.4		 2q0iA-2ohhA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		4 ASP A 326
HIS A 273
SER A 304
LEU A 302
 GUN  A 600 ( 2.5A)
GUN  A 600 (-3.9A)
None
None
 1.04A 2q0iA-2oodA:
undetectable		 2q0iA-2oodA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p87 PRE-MRNA-SPLICING
FACTOR PRP8

(Caenorhabditis
elegans) 		PF01398
(JAB)
PF08084
(PROCT) 		4 ASP A2185
LEU A2181
HIS A2172
SER A2210
 None
 1.10A 2q0iA-2p87A:
undetectable		 2q0iA-2p87A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ASP X 229
HIS X 163
SER X 158
LEU X 188
 None
 1.10A 2q0iA-2pmoX:
undetectable		 2q0iA-2pmoX:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 ASP A 384
LEU A 383
HIS A 449
LEU A 429
 None
 1.06A 2q0iA-2qr4A:
undetectable		 2q0iA-2qr4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2d ZN-DEPENDENT
HYDROLASES

(Agrobacterium
fabrum) 		PF00753
(Lactamase_B) 		4 ASP A 115
ASP A 213
HIS A 116
SER A  44
 PO4  A 279 (-2.9A)
ZN  A 277 (-2.0A)
ZN  A 277 ( 3.2A)
None
 1.05A 2q0iA-2r2dA:
12.9		 2q0iA-2r2dA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		4 ASP A 189
ASP A 178
GLU A 107
LEU A 109
 None
 0.95A 2q0iA-2r7dA:
undetectable		 2q0iA-2r7dA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 LEU A 411
SER A 604
LEU A 605
HIS A 602
 None
 0.87A 2q0iA-2v26A:
undetectable		 2q0iA-2v26A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ASP A 326
GLU A 271
HIS A 248
HIS A 132
 ZN  A1494 (-2.7A)
None
ZN  A1495 (-3.4A)
None
 1.09A 2q0iA-2vr2A:
undetectable		 2q0iA-2vr2A:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		8 ASP A  73
ASP A 178
GLU A 182
LEU A 193
HIS A 221
SER A 273
LEU A 277
HIS A 282
 FE2  A 401 ( 2.8A)
FE2  A 401 (-2.5A)
None
CAC  A 403 ( 4.5A)
FE2  A 401 ( 3.4A)
None
CAC  A 403 ( 4.7A)
None
 0.42A 2q0iA-2vw8A:
51.9		 2q0iA-2vw8A:
99.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		4 ASP A  47
HIS A 243
SER A 279
HIS A 249
 MN  A 555 (-3.2A)
FE  A 556 (-3.4A)
None
None
 1.11A 2q0iA-2xmoA:
undetectable		 2q0iA-2xmoA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 GLU A  74
LEU A  49
LEU A 150
HIS A 153
 None
 1.09A 2q0iA-2yr5A:
undetectable		 2q0iA-2yr5A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF01867
(Cas_Cas1) 		4 ASP A 229
GLU A 221
SER A 111
LEU A 115
 None
 1.10A 2q0iA-2yzsA:
undetectable		 2q0iA-2yzsA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE

(Histophilus
somni) 		PF00834
(Ribul_P_3_epim) 		4 ASP A  45
ASP A 192
LEU A 154
LEU A  54
 NI  A 238 (-2.5A)
NI  A 238 (-2.6A)
None
None
 1.08A 2q0iA-3cu2A:
undetectable		 2q0iA-3cu2A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djb HYDROLASE, HD FAMILY

(Bacillus
thuringiensis) 		PF01966
(HD) 		4 ASP A 122
ASP A  59
HIS A  29
HIS A  34
 MG  A 224 (-2.6A)
MG  A 224 (-3.4A)
MG  A 224 (-3.9A)
None
 1.09A 2q0iA-3djbA:
undetectable		 2q0iA-3djbA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ASP A 328
HIS A 277
SER A 308
LEU A 306
 ZN  A1452 (-2.8A)
None
None
None
 1.01A 2q0iA-3e0lA:
undetectable		 2q0iA-3e0lA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ASP A  36
GLU A  81
LEU A 151
SER A  80
 None
 1.07A 2q0iA-3eoqA:
undetectable		 2q0iA-3eoqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8n PEROXIDE OPERON
REGULATOR

(Bacillus
subtilis) 		PF01475
(FUR) 		4 ASP A 104
ASP A  85
LEU A  75
HIS A  91
 MN  A 201 (-2.3A)
MN  A 201 (-2.9A)
None
MN  A 201 (-3.2A)
 0.81A 2q0iA-3f8nA:
undetectable		 2q0iA-3f8nA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		4 ASP A 808
ASP A 697
HIS A 660
SER A 665
 ZN  A   1 (-2.7A)
ZN  A   1 ( 2.9A)
ZN  A   1 (-3.4A)
None
 1.08A 2q0iA-3ibjA:
undetectable		 2q0iA-3ibjA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		4 LEU A 507
HIS A 503
SER A 502
LEU A 531
 None
 1.10A 2q0iA-3j0aA:
undetectable		 2q0iA-3j0aA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwe MGLL PROTEIN

(Homo sapiens) 		PF12146
(Hydrolase_4) 		4 ASP A 207
GLU A  63
HIS A  64
HIS A 282
 None
 0.79A 2q0iA-3jweA:
undetectable		 2q0iA-3jweA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkf PUTATIVE ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASE

(Bacteroides
thetaiotaomicron) 		PF03992
(ABM) 		4 ASP A 120
GLU A  85
SER A  36
LEU A 118
 None
ACT  A 203 ( 3.9A)
P6G  A 206 ( 4.9A)
None
 1.05A 2q0iA-3kkfA:
undetectable		 2q0iA-3kkfA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnp AMIDOHYDROLASE
FAMILY PROTEIN
OLEI01672_1_465

(Oleispira
antarctica) 		PF01979
(Amidohydro_1) 		4 ASP A 331
HIS A 280
SER A 311
LEU A 309
 CA  A 471 (-2.7A)
None
None
None
 1.03A 2q0iA-3lnpA:
undetectable		 2q0iA-3lnpA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens;
synthetic
construct) 		PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2) 		4 ASP E 443
LEU E 456
HIS E 468
HIS E 538
 None
 0.72A 2q0iA-3lvrE:
undetectable		 2q0iA-3lvrE:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olo TWO-COMPONENT SENSOR
HISTIDINE KINASE

(Nostoc sp. PCC
7120) 		PF00989
(PAS) 		4 ASP A  59
LEU A  55
HIS A  65
LEU A  96
 None
 0.97A 2q0iA-3oloA:
undetectable		 2q0iA-3oloA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py6 BETA-LACTAMASE-LIKE

(Brucella
abortus) 		PF12706
(Lactamase_B_2) 		4 ASP A 188
ASP A  90
LEU A 211
HIS A 243
 MN  A 300 (-2.5A)
MN  A 300 ( 2.6A)
None
TAR  A 304 (-4.2A)
 0.96A 2q0iA-3py6A:
10.3		 2q0iA-3py6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1t ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 ASP A 155
ASP A 144
LEU A 174
HIS A 146
 None
 1.12A 2q0iA-3q1tA:
undetectable		 2q0iA-3q1tA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2u METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		4 ASP A  60
ASP A 145
HIS A 195
SER A 199
 FE  A 443 ( 4.2A)
FE  A 443 (-3.2A)
None
None
 1.04A 2q0iA-3r2uA:
14.4		 2q0iA-3r2uA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ASP A 368
ASP A 372
GLU A 423
SER A 425
 None
 1.12A 2q0iA-3sxfA:
undetectable		 2q0iA-3sxfA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Francisella
tularensis) 		PF01380
(SIS) 		4 ASP A 454
HIS A 590
LEU A 255
HIS A 252
 None
 1.06A 2q0iA-3tbfA:
undetectable		 2q0iA-3tbfA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr4 INORGANIC
PYROPHOSPHATASE

(Coxiella
burnetii) 		PF00719
(Pyrophosphatase) 		4 ASP A  64
ASP A  69
GLU A 163
LEU A  68
 MN  A 176 (-3.2A)
MN  A 176 (-2.5A)
None
None
 1.12A 2q0iA-3tr4A:
undetectable		 2q0iA-3tr4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v96 METALLOPROTEINASE
INHIBITOR 1
STROMELYSIN-2

(Homo sapiens;
Homo sapiens) 		PF00965
(TIMP)
PF00413
(Peptidase_M10) 		4 ASP B 169
LEU B 190
HIS B 182
SER A  68
 ZN  B 302 (-2.1A)
None
ZN  B 302 (-3.2A)
None
 1.11A 2q0iA-3v96B:
undetectable		 2q0iA-3v96B:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ASP A 126
GLU A 102
HIS A 103
SER A 139
 None
 1.07A 2q0iA-3w15A:
undetectable		 2q0iA-3w15A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdh ACETYLCHOLINE
BINDING PROTEIN

(Lymnaea
stagnalis) 		PF02931
(Neur_chan_LBD) 		4 ASP A  49
LEU A  39
SER A 116
LEU A  98
 None
 1.06A 2q0iA-3zdhA:
undetectable		 2q0iA-3zdhA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ASP A 391
GLU A 708
LEU A 731
LEU A 384
 None
EDO  A2291 (-2.7A)
None
None
 0.89A 2q0iA-4a4zA:
undetectable		 2q0iA-4a4zA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 ASP A  60
LEU A  51
HIS A  98
SER A  41
 None
 1.07A 2q0iA-4b52A:
undetectable		 2q0iA-4b52A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj3 PERIOD CIRCADIAN
PROTEIN HOMOLOG 3

(Mus musculus) 		PF08447
(PAS_3) 		4 ASP A 311
LEU A 307
SER A 350
HIS A 370
 None
 0.98A 2q0iA-4dj3A:
undetectable		 2q0iA-4dj3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 ASP A 309
HIS A 258
SER A 289
LEU A 287
 ZN  A 501 (-2.6A)
None
None
None
 0.95A 2q0iA-4dykA:
undetectable		 2q0iA-4dykA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		4 ASP A 315
HIS A 264
SER A 295
LEU A 293
 ZN  A 505 ( 2.0A)
ZN  A 505 ( 4.8A)
None
None
 0.91A 2q0iA-4dzhA:
undetectable		 2q0iA-4dzhA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		4 ASP A 220
HIS A 154
SER A 149
LEU A 179
 None
 0.98A 2q0iA-4e7wA:
undetectable		 2q0iA-4e7wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehc PE-PGRS FAMILY
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 ASP A 189
ASP A  36
LEU A  34
HIS A -14
 ZN  A 301 (-2.0A)
ZN  A 301 (-2.3A)
None
ZN  A 301 (-3.1A)
 1.07A 2q0iA-4ehcA:
undetectable		 2q0iA-4ehcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A  40
LEU A  43
HIS A  58
HIS A 111
 None
 1.03A 2q0iA-4ej6A:
undetectable		 2q0iA-4ej6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		4 ASP A 307
HIS A 256
SER A 287
LEU A 285
 NOS  A 501 (-2.8A)
NOS  A 501 (-4.0A)
None
None
 0.93A 2q0iA-4f0sA:
undetectable		 2q0iA-4f0sA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		4 GLU A 414
LEU A  55
SER A 402
HIS A  60
 None
 0.82A 2q0iA-4f0sA:
undetectable		 2q0iA-4f0sA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 GLU A 183
LEU A 166
HIS A 202
SER A 205
 None
 0.80A 2q0iA-4gyoA:
undetectable		 2q0iA-4gyoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ASP A 808
ASP A 697
HIS A 660
SER A 665
 ZN  A1001 (-2.5A)
MG  A1002 ( 2.6A)
ZN  A1001 (-3.4A)
None
 1.09A 2q0iA-4htzA:
undetectable		 2q0iA-4htzA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 ASP A 458
GLU A 438
HIS A 456
LEU A 242
 None
 1.09A 2q0iA-4mifA:
undetectable		 2q0iA-4mifA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		4 ASP A 277
ASP A 262
GLU A 230
LEU A 232
 None
 1.10A 2q0iA-4oqfA:
undetectable		 2q0iA-4oqfA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0v FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 ASP A 160
GLU A 144
SER A 190
HIS A 482
 ARS  A 604 ( 4.8A)
None
None
None
 0.86A 2q0iA-4r0vA:
undetectable		 2q0iA-4r0vA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 ASP A 327
HIS A 276
SER A 307
LEU A 305
 FE  A 481 (-2.8A)
FE  A 481 (-3.9A)
None
None
 0.96A 2q0iA-4v1yA:
undetectable		 2q0iA-4v1yA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w79 PROTEIN N-TERMINAL
GLUTAMINE
AMIDOHYDROLASE

(Homo sapiens) 		PF09764
(Nt_Gln_amidase) 		4 GLU A  30
SER A 144
LEU A 175
HIS A 148
 None
None
None
EDO  A 301 ( 4.6A)
 1.02A 2q0iA-4w79A:
undetectable		 2q0iA-4w79A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 LEU A 267
SER A 325
LEU A 328
HIS A 293
 None
 0.96A 2q0iA-4wd1A:
undetectable		 2q0iA-4wd1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASP A 136
GLU A 164
SER A 121
LEU A 133
 None
 0.94A 2q0iA-4wz9A:
undetectable		 2q0iA-4wz9A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsy RNA POLYMERASE SIGMA
FACTOR RPOD

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04546
(Sigma70_ner) 		4 ASP F 313
HIS F 338
SER F 334
HIS F 331
 None
 1.13A 2q0iA-4xsyF:
undetectable		 2q0iA-4xsyF:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtk CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Thermotoga
maritima) 		PF01867
(Cas_Cas1) 		4 GLU A 148
LEU A 213
SER A 110
LEU A 230
 None
 1.09A 2q0iA-4xtkA:
undetectable		 2q0iA-4xtkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ASP A  50
HIS A 115
SER A 119
HIS A 156
 None
 1.13A 2q0iA-4zrsA:
undetectable		 2q0iA-4zrsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		4 ASP A 248
LEU A 253
LEU A 191
HIS A 227
 None
None
None
FE  A1311 ( 3.9A)
 1.11A 2q0iA-5advA:
undetectable		 2q0iA-5advA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsw RNA DEPENDENT RNA
POLYMERASE QDE-1

(Thielavia
terrestris) 		PF05183
(RdRP) 		4 ASP A 664
LEU A 671
SER A 694
LEU A 288
 None
 1.06A 2q0iA-5fswA:
undetectable		 2q0iA-5fswA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASP A 652
HIS A 587
SER A 648
HIS A 650
 None
 0.99A 2q0iA-5h1kA:
undetectable		 2q0iA-5h1kA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL

(Caenorhabditis
elegans) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF16526
(CLZ) 		4 ASP A 357
LEU A 336
SER A 350
LEU A 351
 None
 1.06A 2q0iA-5h3oA:
undetectable		 2q0iA-5h3oA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH

(synthetic
construct) 		PF00753
(Lactamase_B) 		4 ASP A 118
LEU A  34
HIS A 268
LEU A  90
 ZN  A 401 ( 2.5A)
PEG  A 403 ( 4.8A)
ZN  A 401 ( 3.2A)
None
 1.07A 2q0iA-5hifA:
15.2		 2q0iA-5hifA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 ASP A 686
GLU A 728
LEU A 744
SER A 864
 None
 1.03A 2q0iA-5im3A:
undetectable		 2q0iA-5im3A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF03814
(KdpA)
PF02669
(KdpC) 		4 GLU A 121
SER C  82
LEU C 128
HIS A 242
 None
 0.97A 2q0iA-5mrwA:
undetectable		 2q0iA-5mrwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		4 ASP A 544
ASP A 699
HIS A 759
SER A 761
 ZN  A 902 ( 2.6A)
ZN  A 902 (-2.3A)
ZN  A 902 ( 3.2A)
None
 0.81A 2q0iA-5mtzA:
7.3		 2q0iA-5mtzA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 4 ASP A 204
GLU A  40
HIS A  41
HIS A 287
 None
 0.72A 2q0iA-5o7gA:
undetectable		 2q0iA-5o7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 ASP T3112
GLU T3684
LEU T3688
HIS T3146
 None
 0.95A 2q0iA-5ojsT:
undetectable		 2q0iA-5ojsT:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v91 FOSFOMYCIN
RESISTANCE PROTEIN

(Klebsiella
pneumoniae) 		PF00903
(Glyoxalase) 		4 ASP A 106
LEU A 112
HIS A 110
LEU A   8
 None
 1.07A 2q0iA-5v91A:
undetectable		 2q0iA-5v91A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaz DNA PRIMASE

(Pseudomonas
aeruginosa) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13662
(Toprim_4) 		4 ASP A 272
ASP A 312
LEU A 343
LEU A 276
 None
 1.07A 2q0iA-5vazA:
undetectable		 2q0iA-5vazA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3

(Escherichia
coli) 		PF00903
(Glyoxalase) 		4 ASP A 106
LEU A 112
HIS A 110
LEU A   8
 None
 1.09A 2q0iA-5vb0A:
undetectable		 2q0iA-5vb0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfz GP33

(Mycobacterium
virus Brujita) 		no annotation 4 LEU A 251
SER A 262
LEU A 263
HIS A 260
 None
 1.11A 2q0iA-5vfzA:
undetectable		 2q0iA-5vfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjm CADHERIN-23

(Mus musculus) 		no annotation 4 ASP A1892
ASP A1931
GLU A1929
SER A1838
 CA  A2006 (-3.2A)
CA  A2005 ( 2.7A)
None
None
 1.12A 2q0iA-5wjmA:
undetectable		 2q0iA-5wjmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 4 ASP A 164
ASP A  71
HIS A 221
SER A 220
 ZN  A 302 ( 2.5A)
ZN  A 302 (-2.7A)
ZN  A 302 (-3.4A)
None
 1.07A 2q0iA-6brmA:
7.6		 2q0iA-6brmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 4 ASP A 140
LEU A 166
HIS A 111
LEU A 147
 None
 1.13A 2q0iA-6bs7A:
undetectable		 2q0iA-6bs7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 4 ASP A 117
ASP A 211
GLU A 113
SER A  53
 None
 1.04A 2q0iA-6et9A:
undetectable		 2q0iA-6et9A:
undetectable