SIMILAR PATTERNS OF AMINO ACIDS FOR 2PWS_A_IBPA3960

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		4 LEU A 227
ILE A 234
TRP A 337
LYS A 223
 None
None
None
ADP  A 421 (-2.7A)
 1.33A 2pwsA-13pkA:
0.0		 2pwsA-13pkA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 LEU A 351
ILE A 406
TRP A 411
LYS A 347
 None
None
None
NDP  A 601 (-2.8A)
 1.39A 2pwsA-5ktkA:
0.0		 2pwsA-5ktkA:
14.09