SIMILAR PATTERNS OF AMINO ACIDS FOR 2PRG_B_BRLB2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		5 LEU A 311
VAL A  76
HIS A 305
LEU A  43
LEU A  52
 None
 1.48A 2prgB-1gzvA:
undetectable		 2prgB-1gzvA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 HIS A 478
LEU A 576
VAL A 555
MET A 498
LEU A 437
 None
 1.48A 2prgB-1jy1A:
0.0		 2prgB-1jy1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)

(Thermococcus
kodakarensis) 		PF01035
(DNA_binding_1)
PF09153
(DUF1938) 		5 TYR A 112
LEU A 115
VAL A  96
MET A 130
LEU A 164
 SO4  A 301 (-4.4A)
None
None
None
None
 1.33A 2prgB-1mgtA:
undetectable		 2prgB-1mgtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 LEU A 209
VAL A 217
HIS A 231
LEU A 296
TYR A 285
 None
 1.41A 2prgB-1wmrA:
undetectable		 2prgB-1wmrA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		5 SER A 201
LEU A 207
VAL A  24
LEU A 219
LEU A 227
 None
 1.28A 2prgB-2a5hA:
undetectable		 2prgB-2a5hA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		no annotation 5 HIS A 120
TYR A 275
LEU A 272
VAL A 108
LEU A 212
 None
 1.49A 2prgB-2b2nA:
0.0		 2prgB-2b2nA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		5 TYR A 515
LEU A 314
LEU A 379
LEU A 501
TYR A 497
 None
 1.37A 2prgB-2btvA:
undetectable		 2prgB-2btvA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db2 KIAA0890 PROTEIN

(Homo sapiens) 		PF00035
(dsrm) 		5 CYH A 134
LEU A  90
LEU A 149
LEU A 142
TYR A 155
 None
 1.45A 2prgB-2db2A:
undetectable		 2prgB-2db2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus scrofa) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 HIS A 160
LEU A 153
VAL A 141
LEU A 120
TYR A 116
 None
 1.40A 2prgB-2gsrA:
0.0		 2prgB-2gsrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		5 SER A  31
LEU A 180
VAL A 175
HIS A 187
TYR A 152
 TTP  A1210 (-3.3A)
None
None
None
None
 1.31A 2prgB-2jcsA:
0.0		 2prgB-2jcsA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myi EXODEOXYRIBONUCLEASE
III

(Pseudomonas sp.
Lz4W) 		PF03372
(Exo_endo_phos) 		5 TYR A 253
LEU A 228
VAL A 102
LEU A 249
LEU A 191
 None
 1.46A 2prgB-2myiA:
undetectable		 2prgB-2myiA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 HIS A 561
LEU A 566
VAL A 330
LEU A 511
LEU A 287
 None
 1.32A 2prgB-2nyfA:
0.0		 2prgB-2nyfA:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.81A 2prgB-2p54A:
35.1		 2prgB-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 273
CYH A 276
SER A 280
LEU A 321
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.91A 2prgB-2p54A:
35.1		 2prgB-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		5 PHE A 217
LEU A 113
LEU A 296
LEU A 184
TYR A 292
 None
 1.39A 2prgB-2ps3A:
undetectable		 2prgB-2ps3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		5 HIS A 323
TYR A 265
LEU A 272
VAL A 158
LEU A 330
 None
 1.41A 2prgB-2qa1A:
undetectable		 2prgB-2qa1A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		5 HIS A 323
TYR A 265
LEU A 272
VAL A 158
LEU A 330
 None
 1.40A 2prgB-2qa2A:
undetectable		 2prgB-2qa2A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 HIS A  87
TYR A 104
VAL A  16
HIS A 121
LEU A 117
 None
 1.29A 2prgB-2vrcA:
undetectable		 2prgB-2vrcA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 TYR A 104
VAL A  16
HIS A 121
LEU A 117
LEU A  83
 None
 1.26A 2prgB-2vrcA:
undetectable		 2prgB-2vrcA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy2 PROTEIN LEAFY

(Arabidopsis
thaliana) 		PF17538
(C_LFY_FLO) 		5 CYH A 348
SER A 327
LEU A 257
VAL A 341
LEU A 373
 None
 1.33A 2prgB-2vy2A:
undetectable		 2prgB-2vy2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE

(Neisseria
meningitidis) 		PF07922
(Glyco_transf_52) 		5 SER A 256
LEU A 253
VAL A 290
LEU A 344
TYR A 348
 None
 1.49A 2prgB-2yk6A:
undetectable		 2prgB-2yk6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		5 PHE A 198
SER A  64
HIS A 170
LEU A 129
LEU A  17
 None
 1.08A 2prgB-2zu0A:
undetectable		 2prgB-2zu0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 CYH A 270
SER A 254
LEU A 112
LEU A 250
LEU A  87
 None
 1.45A 2prgB-3aatA:
undetectable		 2prgB-3aatA:
24.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 PHE A 282
CYH A 285
SER A 289
HIS A 323
TYR A 327
LEU A 330
VAL A 339
MET A 364
HIS A 449
LEU A 453
LEU A 469
TYR A 473
 MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.6A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.45A 2prgB-3b0qA:
38.8		 2prgB-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 285
HIS A 323
LEU A 330
HIS A 449
LEU A 469
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
L41  A 501 (-3.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.74A 2prgB-3d5fA:
34.9		 2prgB-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 HIS A 323
LEU A 330
VAL A 334
HIS A 449
TYR A 473
 L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
None
L41  A 501 (-3.9A)
L41  A 501 (-4.8A)
 1.18A 2prgB-3d5fA:
34.9		 2prgB-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
CYH A 285
HIS A 323
LEU A 330
LEU A 469
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.82A 2prgB-3d5fA:
34.9		 2prgB-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 CYH D 285
TYR D 327
LEU D 330
VAL D 339
MET D 364
HIS D 449
 PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.8A)
None
 0.93A 2prgB-3dzuD:
35.8		 2prgB-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 PHE D 282
CYH D 285
LEU D 330
VAL D 339
MET D 364
 None
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.8A)
 1.00A 2prgB-3dzuD:
35.8		 2prgB-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 PHE D 282
SER D 289
LEU D 330
VAL D 339
MET D 364
LEU D 469
TYR D 473
 None
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.8A)
None
None
 0.72A 2prgB-3dzuD:
35.8		 2prgB-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 SER D 289
LEU D 330
VAL D 339
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.8A)
None
None
None
 0.81A 2prgB-3dzuD:
35.8		 2prgB-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 TYR D 327
LEU D 330
VAL D 339
MET D 364
HIS D 449
LEU D 469
TYR D 473
 None
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.8A)
None
None
None
 0.95A 2prgB-3dzuD:
35.8		 2prgB-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 CYH A 257
HIS A 230
VAL A 274
LEU A 206
TYR A 226
 None
None
EPE  A 996 (-3.8A)
None
None
 1.25A 2prgB-3etcA:
undetectable		 2prgB-3etcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		5 PHE A 158
HIS A  41
VAL A  53
LEU A  85
LEU A  74
 None
 1.42A 2prgB-3gr8A:
undetectable		 2prgB-3gr8A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjh TRANSCRIPTION-REPAIR
-COUPLING FACTOR

(Escherichia
coli) 		no annotation 5 HIS A 120
TYR A 275
LEU A 272
VAL A 108
LEU A 212
 None
 1.45A 2prgB-3hjhA:
undetectable		 2prgB-3hjhA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		5 TYR A 266
LEU A 259
VAL A 256
LEU A 468
TYR A 467
 None
None
FAD  A 600 (-4.3A)
None
None
 1.41A 2prgB-3i6dA:
undetectable		 2prgB-3i6dA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it7 PROTEASE LASA

(Pseudomonas
aeruginosa) 		PF01551
(Peptidase_M23) 		5 LEU A  99
VAL A  87
HIS A  55
LEU A   6
LEU A 180
 None
 1.45A 2prgB-3it7A:
undetectable		 2prgB-3it7A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		5 PHE A 294
HIS A  45
LEU A 280
MET A 249
LEU A 219
 None
 1.50A 2prgB-3ix1A:
undetectable		 2prgB-3ix1A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES10

(Plasmodium
falciparum) 		PF03501
(S10_plectin) 		5 HIS O  45
TYR O  25
LEU O  26
VAL O  66
HIS O  43
 None
 1.38A 2prgB-3j7aO:
undetectable		 2prgB-3j7aO:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 HIS A 355
LEU A 385
VAL A 615
MET A 428
LEU A 286
 None
 1.32A 2prgB-3jbhA:
undetectable		 2prgB-3jbhA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lre KINESIN-LIKE PROTEIN
KIF18A

(Homo sapiens) 		PF00225
(Kinesin) 		5 LEU A 160
VAL A 189
HIS A 229
LEU A 285
LEU A 110
 None
 1.48A 2prgB-3lreA:
undetectable		 2prgB-3lreA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 220
LEU A 222
VAL A 268
MET A 286
LEU A 239
 None
 1.30A 2prgB-3n3zA:
undetectable		 2prgB-3n3zA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu8 AMINOTRANSFERASE
WBPE

(Pseudomonas
aeruginosa) 		PF01041
(DegT_DnrJ_EryC1) 		5 PHE A   4
LEU A 357
VAL A 294
MET A 337
LEU A 345
 None
 1.34A 2prgB-3nu8A:
undetectable		 2prgB-3nu8A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		no annotation 5 TYR I 122
LEU I 124
VAL I 138
LEU I  71
LEU I 276
 None
 1.47A 2prgB-3opyI:
undetectable		 2prgB-3opyI:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		5 PHE A 107
CYH A 102
VAL A  31
LEU A 249
LEU A 230
 None
 1.12A 2prgB-3qatA:
undetectable		 2prgB-3qatA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3son HYPOTHETICAL NUDIX
HYDROLASE

(Listeria
monocytogenes) 		PF00293
(NUDIX) 		5 PHE A  34
LEU A  96
VAL A 103
LEU A 133
LEU A  68
 None
 1.28A 2prgB-3sonA:
undetectable		 2prgB-3sonA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 PHE A 230
CYH A 231
HIS A 233
LEU A 209
TYR A 205
 None
None
COA  A 601 (-4.8A)
None
None
 1.32A 2prgB-3sqzA:
undetectable		 2prgB-3sqzA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		5 HIS A 319
LEU A 324
LEU A  87
LEU A 148
TYR A 144
 None
 1.34A 2prgB-3w4kA:
undetectable		 2prgB-3w4kA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		5 PHE A 227
SER A  73
LEU A  67
LEU A 701
LEU A 668
 None
 1.30A 2prgB-3wonA:
undetectable		 2prgB-3wonA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		5 PHE A 250
HIS A 387
LEU A 215
LEU A 395
TYR A 393
 None
 1.38A 2prgB-4cyfA:
undetectable		 2prgB-4cyfA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN

(Arabidopsis
thaliana) 		PF16035
(Chalcone_2) 		5 PHE A 130
SER A 110
LEU A 148
LEU A 180
TYR A 181
 None
DAO  A 301 (-2.8A)
None
None
None
 1.13A 2prgB-4dooA:
undetectable		 2prgB-4dooA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		5 PHE A 619
CYH A 643
LEU A 652
VAL A 649
LEU A 616
 None
 1.35A 2prgB-4ecnA:
undetectable		 2prgB-4ecnA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 5 PHE A 617
CYH A 641
LEU A 650
VAL A 647
LEU A 614
 None
 1.50A 2prgB-4ecoA:
undetectable		 2prgB-4ecoA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		5 LEU A  89
VAL A 252
HIS A 260
LEU A 322
TYR A 318
 None
 1.39A 2prgB-4emyA:
undetectable		 2prgB-4emyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 CYH A 328
SER A 490
TYR A 855
VAL A 861
LEU A 528
 None
 1.42A 2prgB-4gl2A:
undetectable		 2prgB-4gl2A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyi RIO2 KINASE

(Chaetomium
thermophilum) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 LEU A  86
VAL A  98
MET A   8
LEU A  57
LEU A  76
 None
 1.44A 2prgB-4gyiA:
undetectable		 2prgB-4gyiA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		5 CYH A 117
SER A 106
HIS A 109
LEU A  63
LEU A 114
 None
 1.43A 2prgB-4irtA:
undetectable		 2prgB-4irtA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		5 HIS A 340
TYR A 282
LEU A 289
VAL A 172
LEU A 347
 None
 1.40A 2prgB-4k5rA:
undetectable		 2prgB-4k5rA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 5 PHE A  27
CYH A  26
SER A  94
LEU A 269
LEU A 119
 None
 1.25A 2prgB-4l9aA:
undetectable		 2prgB-4l9aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		5 PHE A 861
TYR A 821
LEU A 838
VAL A 878
LEU A 918
 None
 1.17A 2prgB-4lglA:
undetectable		 2prgB-4lglA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6b SERINE
ACETYLTRANSFERASE
APOENZYME

(Glycine max) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		5 SER A 110
TYR A  41
LEU A  38
HIS A  59
LEU A 120
 None
 1.42A 2prgB-4n6bA:
undetectable		 2prgB-4n6bA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4owt INTEGRATOR COMPLEX
SUBUNIT 3

(Homo sapiens) 		PF10189
(Ints3) 		5 CYH A 354
LEU A 395
VAL A 418
LEU A 305
LEU A 301
 None
 1.49A 2prgB-4owtA:
undetectable		 2prgB-4owtA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		5 PHE A 252
SER A 261
LEU A 273
MET A 389
LEU A 218
 None
 1.46A 2prgB-4r4zA:
undetectable		 2prgB-4r4zA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r84 SIALYLTRANSFERASE
0160

(Photobacterium
damselae) 		PF11477
(PM0188) 		5 HIS A 279
TYR A 286
LEU A 226
LEU A 250
TYR A 306
 None
 1.50A 2prgB-4r84A:
undetectable		 2prgB-4r84A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tm3 KTZI

(Kutzneria sp.
744) 		PF13434
(K_oxygenase) 		5 PHE A  19
SER A  39
VAL A 146
LEU A 118
LEU A  30
 None
 1.44A 2prgB-4tm3A:
undetectable		 2prgB-4tm3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 HIS A 389
LEU A 353
LEU A 129
LEU A 106
TYR A 109
 None
 1.25A 2prgB-4txaA:
undetectable		 2prgB-4txaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 SER A 818
HIS A 289
TYR A 778
VAL A 795
LEU A 363
 None
 1.33A 2prgB-4u48A:
undetectable		 2prgB-4u48A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueg GLYCOGENIN-2

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		5 LEU A  94
VAL A  38
HIS A 148
LEU A 152
TYR A  71
 None
 1.15A 2prgB-4uegA:
undetectable		 2prgB-4uegA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		5 PHE B 478
LEU B 531
HIS B 490
LEU B 185
TYR B 190
 None
 1.50A 2prgB-4xmmB:
undetectable		 2prgB-4xmmB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrm UDP-GLUCOSE
4-EPIMERASE

(Thermotoga
maritima) 		PF01370
(Epimerase) 		5 SER A 104
LEU A   4
VAL A  30
LEU A 154
LEU A 163
 None
 1.37A 2prgB-4zrmA:
undetectable		 2prgB-4zrmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		5 SER A 346
LEU A 105
VAL A 100
HIS A 161
LEU A   4
 None
None
None
LLP  A 187 ( 3.6A)
None
 1.32A 2prgB-4zwvA:
undetectable		 2prgB-4zwvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02783
(MCR_beta_N) 		5 SER B 329
HIS B 364
VAL C 136
LEU C 120
TYR A 446
 None
None
None
COM  A 601 ( 4.6A)
None
 1.44A 2prgB-5a8rB:
undetectable		 2prgB-5a8rB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggk PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF15711
(ILEI) 		5 PHE A 212
LEU A 136
VAL A 114
LEU A 196
LEU A 164
 None
 1.14A 2prgB-5ggkA:
undetectable		 2prgB-5ggkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		5 HIS A 221
LEU A 178
VAL A 203
LEU A 259
TYR A  38
 ACY  A 405 (-4.1A)
None
None
None
None
 1.41A 2prgB-5gw8A:
undetectable		 2prgB-5gw8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 HIS A 267
TYR A 265
VAL A 322
LEU A 215
TYR A 217
 None
 1.47A 2prgB-5hy7A:
undetectable		 2prgB-5hy7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 PHE A 309
LEU A 323
VAL A 319
LEU A 347
LEU A 396
 None
 1.33A 2prgB-5irmA:
undetectable		 2prgB-5irmA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
RACK1

(Kluyveromyces
lactis) 		PF01092
(Ribosomal_S6e) 		5 LEU g  14
VAL g 319
LEU g  95
LEU g  43
TYR g  62
 None
 1.24A 2prgB-5it9g:
undetectable		 2prgB-5it9g:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7k PROTEIN UNC-119
HOMOLOG A

(Homo sapiens) 		PF05351
(GMP_PDE_delta) 		5 PHE A  91
SER A 218
HIS A 165
TYR A 234
TYR A 194
 None
 1.28A 2prgB-5l7kA:
undetectable		 2prgB-5l7kA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		5 PHE S  76
LEU S 183
VAL S 163
LEU S  34
LEU S  57
 None
 1.44A 2prgB-5mpdS:
undetectable		 2prgB-5mpdS:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus) 		no annotation 5 PHE A 166
HIS A  39
VAL A  51
LEU A  83
LEU A  72
 None
 1.43A 2prgB-5nuxA:
undetectable		 2prgB-5nuxA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 PHE A 184
LEU A 130
VAL A 102
LEU A 169
TYR A 227
 None
None
NDP  A 702 (-4.5A)
None
None
 1.36A 2prgB-5t0lA:
undetectable		 2prgB-5t0lA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus) 		PF08904
(DUF1849) 		5 LEU A  33
VAL A  31
LEU A 263
LEU A 250
TYR A  40
 None
None
None
None
EDO  A 303 (-4.9A)
 1.36A 2prgB-5uc2A:
undetectable		 2prgB-5uc2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 TYR A  92
LEU A 116
VAL A 205
LEU A  52
TYR A  50
 None
 1.30A 2prgB-6ap6A:
undetectable		 2prgB-6ap6A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 5 HIS A 325
TYR A 267
LEU A 274
VAL A 157
LEU A 332
 None
 1.40A 2prgB-6brdA:
undetectable		 2prgB-6brdA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 5 PHE A 158
HIS A 111
LEU A  75
LEU A 187
TYR A 110
 None
 1.32A 2prgB-6bs7A:
undetectable		 2prgB-6bs7A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 5 HIS A 324
TYR A 266
LEU A 273
VAL A 157
LEU A 331
 None
 1.38A 2prgB-6c7sA:
undetectable		 2prgB-6c7sA:
15.15