SIMILAR PATTERNS OF AMINO ACIDS FOR 2PRG_A_BRLA1_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		3 ILE A  39
ILE A 121
LEU A 217
 None
None
PLP  A 413 ( 4.1A)
 0.44A 2prgA-1a3gA:
0.0		 2prgA-1a3gA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 ILE A 134
ILE A  71
LEU A 356
 None
 0.54A 2prgA-1b3bA:
0.0		 2prgA-1b3bA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbp BILIN BINDING
PROTEIN

(Pieris
brassicae) 		PF00061
(Lipocalin) 		3 ILE A 114
ILE A  88
LEU A 165
 None
 0.52A 2prgA-1bbpA:
undetectable		 2prgA-1bbpA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0b INTERNALIN B

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4) 		3 ILE A  81
ILE A  88
LEU A 144
 None
 0.55A 2prgA-1d0bA:
0.0		 2prgA-1d0bA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddz CARBONIC ANHYDRASE

(Porphyridium
purpureum) 		PF00484
(Pro_CA) 		3 ILE A 432
ILE A 182
LEU A 399
 None
 0.53A 2prgA-1ddzA:
0.0		 2prgA-1ddzA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 ILE A  91
ILE A   6
LEU A 319
 None
 0.54A 2prgA-1gsoA:
0.0		 2prgA-1gsoA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h31 DIHEME CYTOCHROME C

(Rhodovulum
sulfidophilum) 		no annotation 3 ILE A 165
ILE A 223
LEU A  24
 None
HEC  A1263 ( 4.9A)
None
 0.47A 2prgA-1h31A:
0.0		 2prgA-1h31A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34

(Pisum sativum) 		PF04548
(AIG1) 		3 ILE A 158
ILE A  42
LEU A 195
 None
 0.43A 2prgA-1h65A:
0.0		 2prgA-1h65A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7g 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF02348
(CTP_transf_3) 		3 ILE A 175
ILE A   5
LEU A 205
 None
 0.55A 2prgA-1h7gA:
0.0		 2prgA-1h7gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqz ACTIN-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00241
(Cofilin_ADF) 		3 ILE 1  35
ILE 1   6
LEU 1 126
 None
 0.57A 2prgA-1hqz1:
undetectable		 2prgA-1hqz1:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inp INOSITOL
POLYPHOSPHATE
1-PHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		3 ILE A 307
ILE A 285
LEU A 325
 None
 0.57A 2prgA-1inpA:
undetectable		 2prgA-1inpA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 ILE A  75
ILE A 156
LEU A 289
 None
 0.53A 2prgA-1ir6A:
undetectable		 2prgA-1ir6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc9 TECHYLECTIN-5A

(Tachypleus
tridentatus) 		PF00147
(Fibrinogen_C) 		3 ILE A  92
ILE A 162
LEU A 145
 None
 0.56A 2prgA-1jc9A:
undetectable		 2prgA-1jc9A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jo0 HYPOTHETICAL PROTEIN
HI1333

(Haemophilus
influenzae) 		PF01985
(CRS1_YhbY) 		3 ILE A  48
ILE A  67
LEU A  96
 None
 0.54A 2prgA-1jo0A:
undetectable		 2prgA-1jo0A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ILE A 349
ILE A 359
LEU A 376
 None
 0.57A 2prgA-1kblA:
undetectable		 2prgA-1kblA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Homo sapiens) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		3 ILE A 179
ILE A 161
LEU A 118
 None
 0.53A 2prgA-1kl9A:
undetectable		 2prgA-1kl9A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 ILE A 447
ILE A  68
LEU A 510
 None
 0.58A 2prgA-1la2A:
undetectable		 2prgA-1la2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01913
(FTR)
PF02741
(FTR_C) 		3 ILE A 168
ILE A 201
LEU A 296
 None
 0.56A 2prgA-1m5hA:
undetectable		 2prgA-1m5hA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5s FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Methanosarcina
barkeri) 		PF01913
(FTR)
PF02741
(FTR_C) 		3 ILE A 168
ILE A 201
LEU A 296
 None
 0.56A 2prgA-1m5sA:
undetectable		 2prgA-1m5sA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9s INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF09479
(Flg_new)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13457
(SH3_8) 		3 ILE A  81
ILE A  88
LEU A 144
 None
 0.53A 2prgA-1m9sA:
undetectable		 2prgA-1m9sA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mmf GLYCEROL DEHYDRASE
BETA SUBUNIT

(Klebsiella
pneumoniae) 		PF02288
(Dehydratase_MU) 		3 ILE B  54
ILE B 135
LEU B 191
 None
 0.50A 2prgA-1mmfB:
undetectable		 2prgA-1mmfB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607

(Haemophilus
influenzae) 		PF08501
(Shikimate_dh_N) 		3 ILE A 178
ILE A 233
LEU A 171
 None
 0.58A 2prgA-1npyA:
undetectable		 2prgA-1npyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		3 ILE A  19
ILE A 430
LEU A 234
 FAD  A 652 (-4.8A)
None
None
 0.52A 2prgA-1o5wA:
undetectable		 2prgA-1o5wA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		3 ILE A 490
ILE A 536
LEU A 423
 None
 0.57A 2prgA-1oa1A:
undetectable		 2prgA-1oa1A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogd HIGH AFFINITY RIBOSE
TRANSPORT PROTEIN
RBSD

(Bacillus
subtilis) 		PF05025
(RbsD_FucU) 		3 ILE A  24
ILE A  40
LEU A  84
 None
 0.49A 2prgA-1ogdA:
undetectable		 2prgA-1ogdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT

(Propionibacterium
freudenreichii) 		PF01039
(Carboxyl_trans) 		3 ILE A 331
ILE A 500
LEU A 343
 None
 0.54A 2prgA-1on9A:
undetectable		 2prgA-1on9A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ILE A 185
ILE A 232
LEU A 406
 None
 0.51A 2prgA-1p43A:
undetectable		 2prgA-1p43A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		3 ILE A 116
ILE A 197
LEU A  95
 None
 0.40A 2prgA-1r5lA:
undetectable		 2prgA-1r5lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		3 ILE A 627
ILE A 604
LEU A 718
 None
 0.45A 2prgA-1ru3A:
undetectable		 2prgA-1ru3A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6r PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1442

(Thermotoga
maritima) 		PF01740
(STAS) 		3 ILE A  47
ILE A   8
LEU A  92
 None
 0.47A 2prgA-1t6rA:
undetectable		 2prgA-1t6rA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		3 ILE A 339
ILE A 299
LEU A 403
 None
 0.51A 2prgA-1ua4A:
undetectable		 2prgA-1ua4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		3 ILE A  78
ILE A  54
LEU A 160
 None
 0.53A 2prgA-1uv4A:
undetectable		 2prgA-1uv4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		3 ILE A 143
ILE A 282
LEU A  33
 None
 0.54A 2prgA-1vqzA:
undetectable		 2prgA-1vqzA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		3 ILE C 836
ILE C 843
LEU C 748
 None
 0.55A 2prgA-1wa5C:
undetectable		 2prgA-1wa5C:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyd HYPOTHETICAL
ASPARTYL-TRNA
SYNTHETASE

(Sulfurisphaera
tokodaii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ILE A  38
ILE A   7
LEU A 102
 None
 0.51A 2prgA-1wydA:
undetectable		 2prgA-1wydA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		3 ILE A 254
ILE A 367
LEU B  86
 None
 0.52A 2prgA-1xzqA:
undetectable		 2prgA-1xzqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7m HYPOTHETICAL PROTEIN
BSU14040

(Bacillus
subtilis) 		PF01476
(LysM)
PF03734
(YkuD) 		3 ILE A  58
ILE A 140
LEU A   2
 None
 0.54A 2prgA-1y7mA:
undetectable		 2prgA-1y7mA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ILE A 476
ILE A 460
LEU A 321
 None
 0.50A 2prgA-1z1wA:
undetectable		 2prgA-1z1wA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 ILE A 633
ILE A 648
LEU A 678
 None
 0.49A 2prgA-1zcjA:
undetectable		 2prgA-1zcjA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN

(Pyrococcus
horikoshii) 		PF00574
(CLP_protease) 		3 ILE A  58
ILE A  73
LEU A 212
 None
 0.58A 2prgA-2deoA:
undetectable		 2prgA-2deoA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ILE A 335
ILE A   4
LEU A 203
 None
 0.55A 2prgA-2e5vA:
undetectable		 2prgA-2e5vA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ILE A 142
ILE A 113
LEU A 719
 None
 0.56A 2prgA-2e7zA:
undetectable		 2prgA-2e7zA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec4 FAS-ASSOCIATED
FACTOR 1

(Homo sapiens) 		no annotation 3 ILE A 136
ILE A 150
LEU A  40
 None
 0.53A 2prgA-2ec4A:
undetectable		 2prgA-2ec4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fdr CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF13419
(HAD_2) 		3 ILE A   7
ILE A 184
LEU A 118
 None
 0.52A 2prgA-2fdrA:
undetectable		 2prgA-2fdrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 ILE A 191
ILE A 136
LEU A 227
 None
 0.54A 2prgA-2fpqA:
undetectable		 2prgA-2fpqA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		3 ILE A 217
ILE A  64
LEU A 132
 None
 0.55A 2prgA-2fwrA:
undetectable		 2prgA-2fwrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		3 ILE A  74
ILE A  36
LEU A 172
 None
 0.41A 2prgA-2gd2A:
undetectable		 2prgA-2gd2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggs 273AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Sulfurisphaera
tokodaii) 		PF04321
(RmlD_sub_bind) 		3 ILE A  62
ILE A 149
LEU A  49
 None
 0.54A 2prgA-2ggsA:
undetectable		 2prgA-2ggsA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		3 ILE A 177
ILE A 255
LEU A 128
 None
 0.57A 2prgA-2gwgA:
undetectable		 2prgA-2gwgA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti) 		PF00285
(Citrate_synt) 		3 ILE A 232
ILE A 325
LEU A 206
 None
 0.55A 2prgA-2h12A:
undetectable		 2prgA-2h12A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3b HUMAN CANCER-RELATED
NTPASE

(Homo sapiens) 		PF03266
(NTPase_1) 		3 ILE A 111
ILE A 157
LEU A  25
 None
 0.44A 2prgA-2i3bA:
undetectable		 2prgA-2i3bA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igs HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF11508
(DUF3218) 		3 ILE A  37
ILE A   4
LEU A 116
 None
 0.41A 2prgA-2igsA:
undetectable		 2prgA-2igsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijr HYPOTHETICAL PROTEIN
API92

(Yersinia
pseudotuberculosis) 		PF06924
(DUF1281) 		3 ILE A  37
ILE A  99
LEU A  66
 None
 0.56A 2prgA-2ijrA:
undetectable		 2prgA-2ijrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 3 ILE A 122
ILE A 153
LEU A 235
 None
 0.53A 2prgA-2invA:
undetectable		 2prgA-2invA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgv TAGATOSE-6-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		3 ILE A   2
ILE A 161
LEU A  71
 None
 0.47A 2prgA-2jgvA:
undetectable		 2prgA-2jgvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jq6 EH DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF12763
(EF-hand_4) 		3 ILE A 113
ILE A  56
LEU A 126
 None
 0.57A 2prgA-2jq6A:
undetectable		 2prgA-2jq6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nm1 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 ILE A 952
ILE A 934
LEU A 875
 None
 0.53A 2prgA-2nm1A:
undetectable		 2prgA-2nm1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 ILE A 951
ILE A 933
LEU A 874
 None
 0.55A 2prgA-2np0A:
undetectable		 2prgA-2np0A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcl LIPOPROTEIN-RELEASIN
G SYSTEM ATP-BINDING
PROTEIN LOLD

(Aquifex
aeolicus) 		PF00005
(ABC_tran) 		3 ILE A 193
ILE A 151
LEU A  63
 None
 0.57A 2prgA-2pclA:
undetectable		 2prgA-2pclA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		3 ILE A 342
ILE A 366
LEU A 267
 UNL  A 414 (-3.1A)
None
None
 0.52A 2prgA-2py6A:
undetectable		 2prgA-2py6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7x UPF0052 PROTEIN
SP_1565

(Streptococcus
pneumoniae) 		PF01933
(UPF0052) 		3 ILE A 218
ILE A   9
LEU A 286
 None
 0.51A 2prgA-2q7xA:
undetectable		 2prgA-2q7xA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ILE A 332
ILE A 345
LEU A 137
 None
 0.57A 2prgA-2qdeA:
undetectable		 2prgA-2qdeA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		3 ILE A 148
ILE A 254
LEU A 208
 None
 0.40A 2prgA-2qqpA:
undetectable		 2prgA-2qqpA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbg PUTATIVE
UNCHARACTERIZED
PROTEIN ST0493

(Sulfurisphaera
tokodaii) 		no annotation 3 ILE A  24
ILE A  53
LEU A 125
 None
 0.57A 2prgA-2rbgA:
undetectable		 2prgA-2rbgA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		3 ILE B 329
ILE B 315
LEU B 398
 None
 0.54A 2prgA-2v9tB:
undetectable		 2prgA-2v9tB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ILE A  61
ILE A  15
LEU A 174
 None
 0.54A 2prgA-2va8A:
undetectable		 2prgA-2va8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf1 CAPSID PROTEIN

(Rabbit
picobirnavirus) 		no annotation 3 ILE A 366
ILE A 472
LEU A 556
 None
 0.54A 2prgA-2vf1A:
undetectable		 2prgA-2vf1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvg KINESIN-2

(Giardia
intestinalis) 		PF00225
(Kinesin) 		3 ILE A  93
ILE A   9
LEU A 292
 None
 0.54A 2prgA-2vvgA:
undetectable		 2prgA-2vvgA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ILE A  10
ILE A 328
LEU A 120
 FAD  A1491 (-4.6A)
None
None
 0.54A 2prgA-2wbaA:
undetectable		 2prgA-2wbaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wj3 1-H-3-HYDROXY-4-OXOQ
UINALDINE
2,4-DIOXYGENASE

(Paenarthrobacter
nitroguajacolicus) 		PF00561
(Abhydrolase_1) 		3 ILE A 123
ILE A  30
LEU A 209
 None
 0.38A 2prgA-2wj3A:
undetectable		 2prgA-2wj3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 ILE A 633
ILE A 648
LEU A 678
 None
 0.40A 2prgA-2x58A:
undetectable		 2prgA-2x58A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 ILE A 633
ILE A 648
LEU A 700
 None
 0.56A 2prgA-2x58A:
undetectable		 2prgA-2x58A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ILE A 184
ILE A 231
LEU A 404
 EDO  A 506 (-4.9A)
None
None
 0.53A 2prgA-2xsxA:
undetectable		 2prgA-2xsxA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn2 UNCHARACTERIZED
PROTEIN YNL108C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		3 ILE A   8
ILE A 196
LEU A  54
 None
 0.53A 2prgA-2yn2A:
undetectable		 2prgA-2yn2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		3 ILE A  19
ILE A 430
LEU A 234
 FAD  A 600 (-4.7A)
None
None
 0.47A 2prgA-2z5xA:
undetectable		 2prgA-2z5xA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		3 ILE A 261
ILE A 465
LEU A 280
 None
 0.56A 2prgA-3agrA:
undetectable		 2prgA-3agrA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150

(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		PF00423
(HN)
PF06214
(SLAM) 		3 ILE A  78
ILE A 107
LEU A 122
 None
 0.55A 2prgA-3alxA:
undetectable		 2prgA-3alxA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alz CDW150

(Saguinus
oedipus) 		PF06214
(SLAM) 		3 ILE B  78
ILE B 107
LEU B 122
 None
 0.53A 2prgA-3alzB:
undetectable		 2prgA-3alzB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayr ENDOGLUCANASE

(Piromyces
rhizinflatus) 		PF00150
(Cellulase) 		3 ILE A  10
ILE A 148
LEU A 348
 None
 0.42A 2prgA-3ayrA:
undetectable		 2prgA-3ayrA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ILE A 281
ILE A 341
LEU A 453
 MC5  A   1 ( 4.8A)
MC5  A   1 (-4.5A)
MC5  A   1 (-4.2A)
 0.48A 2prgA-3b0qA:
40.0		 2prgA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ILE A 183
ILE A 230
LEU A 403
 None
 0.53A 2prgA-3b97A:
undetectable		 2prgA-3b97A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens) 		PF01875
(Memo) 		3 ILE A  74
ILE A  45
LEU A 113
 None
 0.42A 2prgA-3bczA:
undetectable		 2prgA-3bczA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwv PUTATIVE
5'(3')-DEOXYRIBONUCL
EOTIDASE

(Staphylococcus
epidermidis) 		PF06941
(NT5C) 		3 ILE A   6
ILE A 148
LEU A 106
 None
 0.45A 2prgA-3bwvA:
undetectable		 2prgA-3bwvA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		3 ILE A 176
ILE A  70
LEU A 146
 None
 0.52A 2prgA-3c3jA:
undetectable		 2prgA-3c3jA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		3 ILE A 188
ILE A 210
LEU A 155
 None
 0.54A 2prgA-3c3kA:
undetectable		 2prgA-3c3kA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8c METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		3 ILE A 198
ILE A 135
LEU A 179
 None
 0.52A 2prgA-3c8cA:
undetectable		 2prgA-3c8cA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch2 SERINE-REPEAT
ANTIGEN PROTEIN

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		3 ILE X 598
ILE X 648
LEU X 585
 None
 0.54A 2prgA-3ch2X:
undetectable		 2prgA-3ch2X:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		3 ILE A 250
ILE A 210
LEU A 241
 None
 0.54A 2prgA-3e0gA:
undetectable		 2prgA-3e0gA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb8 CYSTEINE
PROTEASE-LIKE VIRA

(Shigella
flexneri) 		PF06872
(EspG) 		3 ILE A 166
ILE A 363
LEU A  69
 None
 0.54A 2prgA-3eb8A:
undetectable		 2prgA-3eb8A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eev CHLORAMPHENICOL
ACETYLTRANSFERASE

(Vibrio cholerae) 		PF00132
(Hexapep) 		3 ILE A 134
ILE A 159
LEU A 172
 None
 0.55A 2prgA-3eevA:
undetectable		 2prgA-3eevA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR

(Shigella
flexneri) 		PF04198
(Sugar-bind) 		3 ILE A 194
ILE A 217
LEU A 185
 None
 0.54A 2prgA-3efbA:
undetectable		 2prgA-3efbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		3 ILE A 164
ILE A 223
LEU A 120
 None
 0.50A 2prgA-3eo7A:
undetectable		 2prgA-3eo7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		3 ILE A 346
ILE A 374
LEU A 279
 None
 0.55A 2prgA-3f8tA:
undetectable		 2prgA-3f8tA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 ILE A 440
ILE A 388
LEU A 432
 None
 0.58A 2prgA-3fedA:
undetectable		 2prgA-3fedA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjo NADPH-CYTOCHROME
P450 REDUCTASE

(Homo sapiens;
Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 ILE A 203
ILE A 110
LEU A 152
 None
None
FMN  A 751 (-4.5A)
 0.52A 2prgA-3fjoA:
undetectable		 2prgA-3fjoA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 ILE A 154
ILE A 187
LEU A 278
 None
 0.53A 2prgA-3fmeA:
undetectable		 2prgA-3fmeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		3 ILE A 183
ILE A 259
LEU A 114
 None
 0.56A 2prgA-3h9pA:
undetectable		 2prgA-3h9pA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		3 ILE A  97
ILE A  81
LEU A 123
 None
 0.49A 2prgA-3hc1A:
undetectable		 2prgA-3hc1A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hva PROTEIN FIMX

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		3 ILE A 304
ILE A 425
LEU A 312
 None
 0.56A 2prgA-3hvaA:
undetectable		 2prgA-3hvaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j82 C-TYPE LECTIN DOMAIN
FAMILY 9 MEMBER A

(Mus musculus) 		PF00059
(Lectin_C) 		3 ILE A 254
ILE A 142
LEU A 221
 None
 0.57A 2prgA-3j82A:
undetectable		 2prgA-3j82A:
20.60