SIMILAR PATTERNS OF AMINO ACIDS FOR 2PO7_B_CHDB503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		3 LEU A 203
PRO A 202
LEU A 206
 None
 0.58A 2po7B-1bxkA:
3.1		 2po7B-1bxkA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 LEU A 410
PRO A 411
LEU A 112
 None
 0.57A 2po7B-1c7tA:
undetectable		 2po7B-1c7tA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 LEU A 106
PRO A 107
LEU A 110
 NAD  A 500 (-3.9A)
NAD  A 500 (-4.5A)
None
 0.52A 2po7B-1evjA:
3.0		 2po7B-1evjA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h29 HIGH-MOLECULAR-WEIGH
T CYTOCHROME C

(Desulfovibrio
vulgaris) 		PF02085
(Cytochrom_CIII) 		3 LEU A 276
PRO A 277
LEU A 399
 None
HEC  A1112 (-3.7A)
None
 0.58A 2po7B-1h29A:
undetectable		 2po7B-1h29A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 LEU A 161
PRO A 160
LEU A 428
 None
 0.58A 2po7B-1h39A:
undetectable		 2po7B-1h39A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 LEU A 713
PRO A 714
LEU A 699
 None
 0.59A 2po7B-1iv8A:
undetectable		 2po7B-1iv8A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9o ALASERPIN

(Manduca sexta) 		PF00079
(Serpin) 		3 LEU I  54
PRO I  53
LEU I  57
 None
 0.51A 2po7B-1k9oI:
undetectable		 2po7B-1k9oI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A

(Homo sapiens) 		PF02301
(HORMA) 		3 LEU A 144
PRO A 145
LEU A 147
 None
 0.54A 2po7B-1klqA:
undetectable		 2po7B-1klqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kps RAN-GTPASE
ACTIVATING PROTEIN 1

(Mus musculus) 		PF07834
(RanGAP1_C) 		3 LEU B 541
PRO B 540
LEU B 544
 None
 0.57A 2po7B-1kpsB:
undetectable		 2po7B-1kpsB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 LEU A 137
PRO A 138
LEU A 143
 None
 0.56A 2po7B-1kvkA:
undetectable		 2po7B-1kvkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		3 LEU A 279
PRO A 280
LEU A 305
 None
 0.57A 2po7B-1l5aA:
undetectable		 2po7B-1l5aA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana) 		PF00161
(RIP) 		3 LEU A 226
PRO A 227
LEU A 230
 None
None
MLY  A 231 ( 4.0A)
 0.51A 2po7B-1llnA:
undetectable		 2po7B-1llnA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk2 SMAD 3

(Homo sapiens) 		PF03166
(MH2) 		3 LEU A 403
PRO A 402
LEU A 406
 None
 0.53A 2po7B-1mk2A:
undetectable		 2po7B-1mk2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mld MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LEU A  16
PRO A  15
LEU A  19
 None
 0.55A 2po7B-1mldA:
3.0		 2po7B-1mldA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 LEU A 294
PRO A 293
LEU A 316
 None
 0.53A 2po7B-1odoA:
undetectable		 2po7B-1odoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 3 LEU A  81
PRO A  80
LEU A  84
 None
 0.56A 2po7B-1onsA:
2.3		 2po7B-1onsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qas PHOSPHOLIPASE C
DELTA-1

(Rattus
norvegicus) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LEU A 425
PRO A 426
LEU A 302
 None
 0.55A 2po7B-1qasA:
3.8		 2po7B-1qasA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2C
1

(Homo sapiens) 		PF02170
(PAZ) 		3 LEU A 323
PRO A 324
LEU A 339
 None
 0.39A 2po7B-1si2A:
undetectable		 2po7B-1si2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE

(Aquifex
aeolicus) 		PF01812
(5-FTHF_cyc-lig) 		3 LEU A 160
PRO A 161
LEU A 129
 None
 0.44A 2po7B-1souA:
undetectable		 2po7B-1souA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 LEU A 549
PRO A 548
LEU A 552
 None
 0.59A 2po7B-1taqA:
2.4		 2po7B-1taqA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us7 HSP90 CO-CHAPERONE
CDC37

(Homo sapiens) 		PF08564
(CDC37_C)
PF08565
(CDC37_M) 		3 LEU B 301
PRO B 302
LEU B 305
 None
 0.48A 2po7B-1us7B:
undetectable		 2po7B-1us7B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvc GLUCOSE-1-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		3 LEU A 214
PRO A 213
LEU A 217
 None
 0.57A 2po7B-1wvcA:
2.4		 2po7B-1wvcA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdn RNA EDITING LIGASE
MP52

(Trypanosoma
brucei) 		PF09414
(RNA_ligase) 		3 LEU A 266
PRO A 265
LEU A 269
 None
 0.57A 2po7B-1xdnA:
undetectable		 2po7B-1xdnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgh METHIONYL-TRNA
FORMYLTRANSFERASE

(Ruminiclostridium
thermocellum) 		PF00551
(Formyl_trans_N) 		3 LEU A  87
PRO A  86
LEU A  90
 None
 0.56A 2po7B-1zghA:
undetectable		 2po7B-1zghA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 239
PRO A 238
LEU A 242
 None
 0.47A 2po7B-1zltA:
undetectable		 2po7B-1zltA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a33 HYPOTHETICAL PROTEIN

(Arabidopsis
thaliana) 		PF03641
(Lysine_decarbox) 		3 LEU A 116
PRO A 117
LEU A  57
 None
 0.42A 2po7B-2a33A:
undetectable		 2po7B-2a33A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		no annotation 3 LEU A 212
PRO A 213
LEU A  92
 None
 0.50A 2po7B-2b2nA:
undetectable		 2po7B-2b2nA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5i CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 LEU C  35
PRO C  36
LEU C 110
 None
 0.47A 2po7B-2b5iC:
undetectable		 2po7B-2b5iC:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 LEU A 266
PRO A 265
LEU A 269
 None
 0.54A 2po7B-2cukA:
4.2		 2po7B-2cukA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		3 LEU A 488
PRO A 489
LEU A 510
 None
 0.51A 2po7B-2dh3A:
undetectable		 2po7B-2dh3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		3 LEU A 140
PRO A 139
LEU A 143
 None
 0.58A 2po7B-2ef4A:
3.0		 2po7B-2ef4A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erj CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 LEU C  35
PRO C  36
LEU C 110
 None
 0.40A 2po7B-2erjC:
undetectable		 2po7B-2erjC:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		3 LEU A 212
PRO A 213
LEU A  92
 None
 0.53A 2po7B-2eyqA:
2.3		 2po7B-2eyqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		3 LEU A  40
PRO A  39
LEU A  43
 MLY  A   3 ( 4.6A)
None
None
 0.53A 2po7B-2ftzA:
undetectable		 2po7B-2ftzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		3 LEU A 377
PRO A 376
LEU A 380
 None
 0.57A 2po7B-2gqwA:
undetectable		 2po7B-2gqwA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2m COMM
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF17221
(COMMD1_N) 		3 LEU A  12
PRO A  11
LEU A  15
 None
 0.56A 2po7B-2h2mA:
undetectable		 2po7B-2h2mA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jq6 EH DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF12763
(EF-hand_4) 		3 LEU A 122
PRO A 123
LEU A  92
 None
 0.54A 2po7B-2jq6A:
undetectable		 2po7B-2jq6A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		3 LEU A 549
PRO A 548
LEU A 552
 None
 0.59A 2po7B-2ktqA:
undetectable		 2po7B-2ktqA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4d SCO1/SENC FAMILY
PROTEIN/CYTOCHROME C

(Pseudomonas
putida) 		PF00034
(Cytochrom_C) 		3 LEU A  59
PRO A  58
LEU A  62
 None
 0.52A 2po7B-2l4dA:
undetectable		 2po7B-2l4dA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyg YOKD PROTEIN

(Bacillus
subtilis) 		PF02522
(Antibiotic_NAT) 		3 LEU A 161
PRO A 160
LEU A 164
 None
 0.56A 2po7B-2nygA:
undetectable		 2po7B-2nygA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 161
PRO A 162
LEU A 172
 None
 0.40A 2po7B-2ppgA:
2.1		 2po7B-2ppgA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4d LYSINE
DECARBOXYLASE-LIKE
PROTEIN AT5G11950

(Arabidopsis
thaliana) 		PF03641
(Lysine_decarbox) 		3 LEU A 112
PRO A 113
LEU A  53
 None
 0.36A 2po7B-2q4dA:
undetectable		 2po7B-2q4dA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 LEU D 431
PRO D 432
LEU D 426
 None
 0.56A 2po7B-2vnuD:
undetectable		 2po7B-2vnuD:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 LEU J 431
PRO J 432
LEU J 426
 None
GOL  J2002 ( 4.1A)
None
 0.56A 2po7B-2wp8J:
undetectable		 2po7B-2wp8J:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
PF07652
(Flavi_DEAD) 		3 LEU A 501
PRO A 502
LEU A 505
 None
 0.54A 2po7B-2wv9A:
4.2		 2po7B-2wv9A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		3 LEU A 374
PRO A 375
LEU A   9
 None
 0.57A 2po7B-2xdqA:
2.7		 2po7B-2xdqA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		3 LEU A  69
PRO A  70
LEU A  75
 None
 0.56A 2po7B-2yysA:
3.0		 2po7B-2yysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0j PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1438

(Thermus
thermophilus) 		PF04029
(2-ph_phosp) 		3 LEU A 188
PRO A 187
LEU A 191
 None
 0.53A 2po7B-2z0jA:
2.8		 2po7B-2z0jA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		3 LEU A 156
PRO A 155
LEU A 159
 None
 0.54A 2po7B-2z3tA:
undetectable		 2po7B-2z3tA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LEU X 448
PRO X 449
LEU X 318
 None
 0.54A 2po7B-2zkmX:
2.4		 2po7B-2zkmX:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 LEU A 106
PRO A 107
LEU A   2
 None
 0.58A 2po7B-2zr2A:
undetectable		 2po7B-2zr2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 LEU A 722
PRO A 723
LEU A 727
 None
 0.49A 2po7B-2zzgA:
undetectable		 2po7B-2zzgA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajf NON-STRUCTURAL
PROTEIN 3

(Rice hoja
blanca
tenuivirus) 		PF05310
(Tenui_NS3) 		3 LEU A  97
PRO A  96
LEU A 100
 None
 0.56A 2po7B-3ajfA:
undetectable		 2po7B-3ajfA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1

(Homo sapiens) 		PF00533
(BRCT) 		3 LEU A1423
PRO A1424
LEU A1430
 None
 0.57A 2po7B-3al2A:
3.8		 2po7B-3al2A:
25.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		3 LEU A 101
PRO A 102
LEU A 107
 CHD  A   3 ( 4.9A)
CHD  A   3 ( 4.7A)
CHD  A   3 ( 4.6A)
 0.20A 2po7B-3aqiA:
60.0		 2po7B-3aqiA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bd9 HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
5

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 LEU A 263
PRO A 262
LEU A 266
 None
 0.57A 2po7B-3bd9A:
3.6		 2po7B-3bd9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		3 LEU A 327
PRO A 326
LEU A 330
 None
 0.48A 2po7B-3bl9A:
undetectable		 2po7B-3bl9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzm HYPOTHETICAL
CONSERVED PROTEIN

(Thermus
thermophilus) 		no annotation 3 LEU A  31
PRO A  32
LEU A  33
 None
 0.55A 2po7B-3dzmA:
undetectable		 2po7B-3dzmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		3 LEU A 541
PRO A 542
LEU A 528
 None
 0.58A 2po7B-3i04A:
3.5		 2po7B-3i04A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A

(Drosophila
melanogaster) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		3 LEU A  42
PRO A  43
LEU A  47
 None
 0.56A 2po7B-3i2tA:
undetectable		 2po7B-3i2tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lul 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Legionella
pneumophila) 		PF01063
(Aminotran_4) 		3 LEU A 136
PRO A 135
LEU A 139
 None
None
LLP  A 140 ( 4.2A)
 0.56A 2po7B-3lulA:
undetectable		 2po7B-3lulA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE

(Actinomadura
kijaniata) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 LEU A 371
PRO A 370
LEU A 374
 None
 0.48A 2po7B-3m9vA:
undetectable		 2po7B-3m9vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxl NITROSOSYNTHASE

(Micromonospora
sp. ATCC 39149) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 LEU A 362
PRO A 361
LEU A 365
 None
 0.45A 2po7B-3mxlA:
undetectable		 2po7B-3mxlA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		3 LEU A 287
PRO A 286
LEU A 290
 None
 0.58A 2po7B-3ndaA:
undetectable		 2po7B-3ndaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)

(Archaeoglobus
fulgidus) 		PF12804
(NTP_transf_3) 		3 LEU A 153
PRO A 152
LEU A 156
 None
 0.53A 2po7B-3ngwA:
undetectable		 2po7B-3ngwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nip 3-GUANIDINOPROPIONAS
E

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		3 LEU A 118
PRO A 119
LEU A 310
 None
 0.59A 2po7B-3nipA:
3.0		 2po7B-3nipA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3og4 INTERLEUKIN-29

(Homo sapiens) 		PF15177
(IL28A) 		3 LEU A  99
PRO A  98
LEU A 102
 None
 0.59A 2po7B-3og4A:
undetectable		 2po7B-3og4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LEU B 453
PRO B 454
LEU B 323
 None
 0.47A 2po7B-3ohmB:
undetectable		 2po7B-3ohmB:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		3 LEU A1439
PRO A1440
LEU A1495
 None
 0.52A 2po7B-3ptaA:
2.2		 2po7B-3ptaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puf RIBONUCLEASE H2
SUBUNIT B

(Homo sapiens) 		PF09468
(RNase_H2-Ydr279) 		3 LEU B  94
PRO B  93
LEU B  97
 None
 0.51A 2po7B-3pufB:
undetectable		 2po7B-3pufB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LEU A 456
PRO A 457
LEU A 329
 None
 0.39A 2po7B-3qr1A:
3.4		 2po7B-3qr1A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 3 LEU N 139
PRO N 138
LEU N 142
 None
 0.45A 2po7B-3rkoN:
undetectable		 2po7B-3rkoN:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bradyrhizobium
sp. ORS 278) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A  62
PRO A  61
LEU A  65
 None
 0.56A 2po7B-3toyA:
undetectable		 2po7B-3toyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf5 MACROPHAGE
COLONY-STIMULATING
FACTOR 1

(Mus musculus) 		PF05337
(CSF-1) 		3 LEU A 111
PRO A 110
LEU A 114
 None
 0.54A 2po7B-3uf5A:
undetectable		 2po7B-3uf5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6j SCPB

(Geobacillus
stearothermophilus) 		PF04079
(SMC_ScpB) 		3 LEU B 134
PRO B 133
LEU B 137
 None
 0.52A 2po7B-3w6jB:
undetectable		 2po7B-3w6jB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis) 		PF02900
(LigB)
PF07746
(LigA) 		3 LEU A 130
PRO A 129
LEU A 133
 None
 0.56A 2po7B-3wrcA:
2.4		 2po7B-3wrcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 LEU A 125
PRO A 124
LEU A 128
 None
 0.55A 2po7B-3zl8A:
4.4		 2po7B-3zl8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 LEU A  82
PRO A  83
LEU A 162
 None
EDO  A1530 ( 4.4A)
None
 0.57A 2po7B-4akoA:
undetectable		 2po7B-4akoA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		3 LEU A 107
PRO A 108
LEU A 111
 None
 0.55A 2po7B-4b98A:
2.3		 2po7B-4b98A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhk FLORICAULA/LEAFY
HOMOLOG 1

(Physcomitrella
patens) 		PF17538
(C_LFY_FLO) 		3 LEU A 305
PRO A 304
LEU A 308
 None
 0.53A 2po7B-4bhkA:
undetectable		 2po7B-4bhkA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 3 LEU A 258
PRO A 259
LEU A 267
 None
 0.59A 2po7B-4bwkA:
undetectable		 2po7B-4bwkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 3 LEU A 244
PRO A 245
LEU A 253
 None
 0.44A 2po7B-4cyjA:
undetectable		 2po7B-4cyjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1

(Methanocaldococcus
jannaschii) 		PF00999
(Na_H_Exchanger) 		3 LEU A  34
PRO A  33
LEU A  37
 None
 0.58A 2po7B-4czbA:
undetectable		 2po7B-4czbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d25 BMVLG PROTEIN

(Bombyx mori) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LEU A 508
PRO A 509
LEU A 543
 None
 0.53A 2po7B-4d25A:
4.0		 2po7B-4d25A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		3 LEU A 247
PRO A 246
LEU A 250
 None
 0.53A 2po7B-4dzhA:
undetectable		 2po7B-4dzhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452) 		3 LEU A 569
PRO A 568
LEU A 572
 None
 0.58A 2po7B-4eljA:
undetectable		 2po7B-4eljA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		3 LEU A 239
PRO A 238
LEU A 242
 None
 0.55A 2po7B-4f0sA:
undetectable		 2po7B-4f0sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		3 LEU A 281
PRO A 280
LEU A 284
 None
 0.57A 2po7B-4f62A:
undetectable		 2po7B-4f62A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fb5 PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 LEU A 193
PRO A 192
LEU A 196
 None
 0.57A 2po7B-4fb5A:
5.1		 2po7B-4fb5A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gio PUTATIVE LIPOPROTEIN

(Campylobacter
jejuni) 		PF07233
(DUF1425) 		3 LEU A  35
PRO A  36
LEU A  31
 BR  A 201 ( 4.8A)
None
None
 0.57A 2po7B-4gioA:
undetectable		 2po7B-4gioA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB

(Acinetobacter
baumannii) 		PF01636
(APH) 		3 LEU A  81
PRO A  82
LEU A  72
 None
0J9  A 302 (-4.5A)
None
 0.51A 2po7B-4gkhA:
undetectable		 2po7B-4gkhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LEU B 453
PRO B 454
LEU B 323
 None
 0.46A 2po7B-4gnkB:
undetectable		 2po7B-4gnkB:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana) 		PF00491
(Arginase) 		3 LEU A 158
PRO A 157
LEU A 161
 None
 0.58A 2po7B-4iu4A:
3.2		 2po7B-4iu4A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k02 1,4-DIHYDROXY-2-NAPH
THOYL-COA
THIOESTERASE

(Arabidopsis
thaliana) 		PF03061
(4HBT) 		3 LEU A  15
PRO A  14
LEU A  18
 None
 0.54A 2po7B-4k02A:
undetectable		 2po7B-4k02A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
oryzae) 		PF01156
(IU_nuc_hydro) 		3 LEU A 401
PRO A 400
LEU A 404
 None
 0.57A 2po7B-4kl0A:
2.8		 2po7B-4kl0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		3 LEU A 323
PRO A 324
LEU A 339
 None
 0.47A 2po7B-4krfA:
4.8		 2po7B-4krfA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noi DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Campylobacter
jejuni) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		3 LEU A  43
PRO A  42
LEU A  46
 None
IOD  A 402 ( 4.2A)
None
 0.58A 2po7B-4noiA:
undetectable		 2po7B-4noiA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt1 ACCELERATED-CELL-DEA
TH 11

(Arabidopsis
thaliana) 		PF08718
(GLTP) 		3 LEU A 158
PRO A 159
LEU A 127
 None
 0.57A 2po7B-4nt1A:
undetectable		 2po7B-4nt1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 LEU A 580
PRO A 581
LEU A 540
 None
 0.56A 2po7B-4o9xA:
undetectable		 2po7B-4o9xA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LEU B 453
PRO B 454
LEU B 323
 None
 0.56A 2po7B-4qj4B:
undetectable		 2po7B-4qj4B:
20.45